Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A

Journal of Molecular and Cellular Cardiology

Volumn 51, Issue 6, 2011, Pages 988-996

  Taglieri, Domenico M ^a   Monasky, Michelle M ^a   Knezevic, Ivana ^a   Sheehan, Katherine A ^a   Lei, Ming ^b   Wang, Xin ^b   Chernoff, Jonathan ^c   Wolska, Beata M ^a   Ke, Yunbo ^a   Solaro, R John ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c FOX CHASE CANCER CENTER   (United States)

Author keywords

Mitogen activated protein kinases; Myocardial hypertrophy; P38 MAPK; Pak 1; Troponin I

Indexed keywords

ADENOVIRUS VECTOR; ENZYME INHIBITOR; ISOPRENALINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; P21 ACTIVATED KINASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC STRESS; CONTROLLED STUDY; DECELERATION; DIASTOLE; DOPPLER ECHOCARDIOGRAPHY; ECHOCARDIOGRAPHY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REPRESSION; FEMALE; HEART MUSCLE; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; M MODE ECHOCARDIOGRAPHY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SYSTOLE; TRANSTHORACIC ECHOCARDIOGRAPHY;

ANIMALS; CALCIUM; CARDIOMEGALY; DISEASE MODELS, ANIMAL; ECHOCARDIOGRAPHY; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GENE KNOCKOUT TECHNIQUES; ISOPROTERENOL; MALE; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MYOCYTES, CARDIAC; MYOFIBRILS; P21-ACTIVATED KINASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN PHOSPHATASE 2; PYRAZOLES; PYRIDAZINES; SIGNAL TRANSDUCTION;

MUS;

EID: 80055121231     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2011.09.016     Document Type: Article

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