Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts

Journal of Molecular and Cellular Cardiology

Volumn 51, Issue 2, 2011, Pages 215-225

  Fedorov, Vadim V ^a   Glukhov, Alexey V ^a   Ambrosi, Christina M ^a   Kostecki, Geran ^a   Chang, Roger ^a   Janks, Deborah ^a   Schuessler, Richard B ^b   Moazami, Nader ^b   Nichols, Colin G ^b   Efimov, Igor R ^a  

^a WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Arrhythmias; Heart failure; Human heart IKATP; Ischemic heart disease; Optical mapping

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; DIAZOXIDE; GLIBENCLAMIDE; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.1; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; MESSENGER RNA; PINACIDIL; SULFONYLUREA RECEPTOR; SULFONYLUREA RECEPTOR 1; SULFONYLUREA RECEPTOR 2; UNCLASSIFIED DRUG;

ADULT; ARRHYTHMOGENESIS; ARTICLE; CLINICAL ARTICLE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; ENDOCARDIUM; FEMALE; GENE EXPRESSION; HEART ARRHYTHMIA; HEART ATRIUM; HEART ATRIUM FIBRILLATION; HEART ATRIUM FLUTTER; HEART INFARCTION; HEART LEFT ATRIUM; HEART LEFT VENTRICLE; HEART MUSCLE POTENTIAL; HEART VENTRICLE; HEART VENTRICLE REMODELING; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL;

ACTION POTENTIALS; ADOLESCENT; ADULT; ARRHYTHMIAS, CARDIAC; CORONARY VESSELS; DIAZOXIDE; FEMALE; GENE EXPRESSION REGULATION; HEART ATRIA; HEART FAILURE; HEART VENTRICLES; HUMANS; KATP CHANNELS; MALE; MIDDLE AGED; MYOCARDIAL ISCHEMIA; PINACIDIL; RNA, MESSENGER; VASODILATOR AGENTS; YOUNG ADULT;

EID: 79959499965     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2011.04.016     Document Type: Article

References (54)

1. Noma A. ATP-regulated K+ channels in cardiac muscle. Nature Sep. 8-14 1983, 305(5930):147-148.
2. Wilde A.A., Escande D., Schumacher C.A., Thuringer D., Mestre M., Fiolet J.W., et al. Potassium accumulation in the globally ischemic mammalian heart. A role for the ATP-sensitive potassium channel. Circ Res Oct. 1990, 67(4):835-843.
3. Zhang H., Flagg T.P., Nichols C.G. Cardiac sarcolemmal K(ATP) channels: latest twists in a questing tale!. J Mol Cell Cardiol Jan. 2010, 48(1):71-75.
4. Venkatesh N., Lamp S.T., Weiss J.N. Sulfonylureas, ATP-sensitive K+ channels, and cellular K+ loss during hypoxia, ischemia, and metabolic inhibition in mammalian ventricle. Circ Res Sep. 1991, 69(3):623-637.
5. Cole W.C., McPherson C.D., Sontag D. ATP-regulated K+ channels protect the myocardium against ischemia/reperfusion damage. Circ Res Sep. 1991, 69(3):571-581.
6. Lee T.M., Lin M.S., Chang N.C. Effect of ATP-sensitive potassium channel agonists on ventricular remodeling in healed rat infarcts. J Am Coll Cardiol Apr 1 2008, 51(13):1309-1318.
7. Padrini R., Bova S., Cargnelli G., Piovan D., Ferrari M. Effects of pinacidil on guinea-pig isolated perfused heart with particular reference to the proarrhythmic effect. Br J Pharmacol Mar 1992, 105(3):715-719.
8. Billman G.E. Role of ATP sensitive potassium channel in extracellular potassium accumulation and cardiac arrhythmias during myocardial ischaemia. Cardiovasc Res Jun 1994, 28(6):762-769.
9. Kantor P.F., Coetzee W.A., Carmeliet E.E., Dennis S.C., Opie L.H. Reduction of ischemic K+ loss and arrhythmias in rat hearts. Effect of glibenclamide, a sulfonylurea. Circ Res Feb. 1990, 66(2):478-485.
10. Picard S., Rouet R., Duval D., Chesnay F., Gerard J.L. KATP channel modulators and myocardial damages induced by ischemia-reperfusion: membrane lipids injury and arrhythmias. J Mol Cell Cardiol Dec. 1998, 30(12):2613-2621.
11. Pountney D.J., Sun Z.Q., Porter L.M., Nitabach M.N., Nakamura T.Y., Holmes D., et al. Is the molecular composition of K(ATP) channels more complex than originally thought?. J Mol Cell Cardiol Aug. 2001, 33(8):1541-1546.
12. Chan K.W., Wheeler A., Csanady L. Sulfonylurea receptors type 1 and 2A randomly assemble to form heteromeric KATP channels of mixed subunit composition. J Gen Physiol Jan. 2008, 131(1):43-58.
13. Liu Y., Ren G., O'Rourke B., Marban E., Seharaseyon J. Pharmacological comparison of native mitochondrial K(ATP) channels with molecularly defined surface K(ATP) channels. Mol Pharmacol Feb. 2001, 59(2):225-230.
14. Flagg T.P., Kurata H.T., Masia R., Caputa G., Magnuson M.A., Lefer D.J., et al. Differential structure of atrial and ventricular KATP: atrial KATP channels require SUR1. Circ Res Dec. 5 2008, 103(12):1458-1465.
15. Glukhov A.V., Flagg T.P., Fedorov V.V., Efimov I.R., Nichols C.G. Differential K(ATP) channel pharmacology in intact mouse heart. J Mol Cell Cardiol Jan. 2010, 48(1):152-160.
16. Pelzmann B., Schaffer P., Bernhart E., Lang P., Machler H., Rigler B., et al. Effects of K+ channel openers on I K(ATP) of human atrial myocytes at physiological temperatures. Naunyn Schmiedebergs Arch Pharmacol Feb. 2001, 363(2):125-132.
17. Balana B., Dobrev D., Wettwer E., Christ T., Knaut M., Ravens U. Decreased ATP-sensitive K(+) current density during chronic human atrial fibrillation. J Mol Cell Cardiol Dec. 2003, 35(12):1399-1405.
18. Wu G., Huang C.X., Tang Y.H., Jiang H., Wan J., Chen H., et al. Changes of IK, ATP current density and allosteric modulation during chronic atrial fibrillation. Chin Med J Engl Jul. 20 2005, 118(14):1161-1166.
19. Raeis V., Philip-Couderc P., Roatti A., Habre W., Sierra J., Kalangos A., et al. Central venous hypoxemia is a determinant of human atrial ATP-sensitive potassium channel expression: evidence for a novel hypoxia-inducible factor 1alpha-Forkhead box class O signaling pathway. Hypertension May 2010, 55(5):1186-1192.
20. Koumi S.I., Martin R.L., Sato R. Alterations in ATP-sensitive potassium channel sensitivity to ATP in failing human hearts. Am J Physiol Apr. 1997, 272(4 Pt 2):H1656-H1665.
21. Gautier P., Bertrand J.P., Guiraudou P. Effects of SR 44866, a potassium channel opener, on action potentials of rabbit, guinea pig, and human heart fibers. J Cardiovasc Pharmacol May 1991, 17(5):692-700.
22. Glukhov A.V., Fedorov V.V., Lou Q., Ravikumar V.K., Kalish P.W., Schuessler R.B., et al. Transmural dispersion of repolarization in failing and nonfailing human ventricle. Circ Res Mar 19 2010, 106(5):981-991.
23. Fedorov V.V., Glukhov A.V., Chang R., Kostecki G., Aferol H., Hucker W.J., et al. Optical mapping of the isolated coronary-perfused human sinus node. J Am Coll Cardiol Oct. 19 2010, 56(17):1386-1394.
24. Fedorov V.V., Lozinsky I.T., Sosunov E.A., Anyukhovsky E.P., Rosen M.R., Balke C.W., et al. Application of blebbistatin as an excitation-contraction uncoupler for electrophysiologic study of rat and rabbit hearts. Heart Rhythm May 2007, 4(5):619-626.
25. Fedorov V.V., Schuessler R.B., Hemphill M., Ambrosi C.M., Chang R., Voloshina A.S., et al. Structural and functional evidence for discrete exit pathways that connect the canine sinoatrial node and atria. Circ Res Apr 10 2009, 104(7):915-923.
26. Fedorov V.V., Kostecki G., Hemphill M., Efimov I.R. Atria are more susceptible to electroporation than ventricles: implications for atrial stunning, shock-induced arrhythmia and defibrillation failure. Heart Rhythm Apr 2008, 5(4):593-604.
27. Fedorov V.V., Chang R., Glukhov A.V., Kostecki G., Janks D., Schuessler R.B., et al. Complex interactions between the sinoatrial node and atrium during reentrant arrhythmias in the canine heart. Circulation Aug 24 2010, 122(8):782-789.
28. Isidoro Tavares N., Philip-Couderc P., Papageorgiou I., Baertschi A.J., Lerch R., Montessuit C. Expression and function of ATP-dependent potassium channels in late post-infarction remodeling. J Mol Cell Cardiol Jun 2007, 42(6):1016-1025.
29. Poitry S., van Bever L., Coppex F., Roatti A., Baertschi A.J. Differential sensitivity of atrial and ventricular K(ATP) channels to metabolic inhibition. Cardiovasc Res Feb 2003, 57(2):468-476.
30. Chi L., Uprichard A.C., Lucchesi B.R. Profibrillatory actions of pinacidil in a conscious canine model of sudden coronary death. J Cardiovasc Pharmacol Mar 1990, 15(3):452-464.
31. Di Diego J.M., Antzelevitch C. Pinacidil-induced electrical heterogeneity and extrasystolic activity in canine ventricular tissues. Does activation of ATP-regulated potassium current promote phase 2 reentry?. Circulation Sep 1993, 88(3):1177-1189.
32. Wettwer E., Hala O., Christ T., Heubach J.F., Dobrev D., Knaut M., et al. Role of IKur in controlling action potential shape and contractility in the human atrium: influence of chronic atrial fibrillation. Circulation Oct 19 2004, 110(16):2299-2306.
33. Hordof A.J., Spotnitz A., Mary-Rabine L., Edie R.N., Rosen M.R. The cellular electrophysiologic effects of digitalis on human atrial fibers. Circulation Feb 1978, 57(2):223-229.
34. Gelband H., Bush H.L., Rosen M.R., Myerburg R.J., Hoffman B.F. Electrophysiologic properties of isolated preparations of human atrial myocardium. Circ Res Mar 1972, 30(3):293-300.
35. Li D., Melnyk P., Feng J., Wang Z., Petrecca K., Shrier A., et al. Effects of experimental heart failure on atrial cellular and ionic electrophysiology. Circulation Jun 6 2000, 101(22):2631-2638.
36. Sanders P., Morton J.B., Davidson N.C., Spence S.J., Vohra J.K., Sparks P.B., et al. Electrical remodeling of the atria in congestive heart failure: electrophysiological and electroanatomic mapping in humans. Circulation Sep 23 2003, 108(12):1461-1468.
37. Ogbaghebriel A., Shrier A. Differential responsiveness of atrial and ventricular myocytes to potassium channel openers. J Cardiovasc Pharmacol Jan 1995, 25(1):65-74.
38. Mull K.P., Debnam Q., Kabir S.M., Bhattacharyya M.L. Role of action potential shortening in the prevention of arrhythmias in canine cardiac tissue. Clin Exp Pharmacol Physiol Dec 1999, 26(12):964-969.
39. Takayama S., Furukawa Y., Murakami M., Chiba S. Pinacidil attenuates positive inotropic but not chronotropic responses to norepinephrine in isolated dog atrial and ventricular preparations. Jpn J Pharmacol Sep 1994, 66(1):115-122.
40. Hanley P.J., Mickel M., Loffler M., Brandt U., Daut J. K(ATP) channel-independent targets of diazoxide and 5-hydroxydecanoate in the heart. J Physiol Aug 1 2002, 542(Pt 3):735-741.
41. Soltysinska E., Olesen S.P., Christ T., Wettwer E., Varro A., Grunnet M., et al. Transmural expression of ion channels and transporters in human nondiseased and end-stage failing hearts. Pflugers Arch Nov 2009, 459(1):11-23.
42. Masia R., Caputa G., Nichols C.G. Regulation of KATP channel expression and activity by the SUR1 nucleotide binding fold 1. Channels Austin 2007, 1(4):315-323.
43. D'Hahan N., Moreau C., Prost A.L., Jacquet H., Alekseev A.E., Terzic A., et al. Pharmacological plasticity of cardiac ATP-sensitive potassium channels toward diazoxide revealed by ADP. Proc Natl Acad Sci USA Oct 12 1999, 96(21):12162-12167.
44. Flagg T.P., Remedi M.S., Masia R., Gomes J., McLerie M., Lopatin A.N., et al. Transgenic overexpression of SUR1 in the heart suppresses sarcolemmal K(ATP). J Mol Cell Cardiol Oct 2005, 39(4):647-656.
45. Koster J.C., Knopp A., Flagg T.P., Markova K.P., Sha Q., Enkvetchakul D., et al. Tolerance for ATP-insensitive K(ATP) channels in transgenic mice. Circ Res Nov 23 2001, 89(11):1022-1029.
46. Wolleben C.D., Sanguinetti M.C., Siegl P.K. Influence of ATP-sensitive potassium channel modulators on ischemia-induced fibrillation in isolated rat hearts. J Mol Cell Cardiol Aug 1989, 21(8):783-788.
47. D'Alonzo A.J., Zhu J.L., Darbenzio R.B., Dorso C.R., Grover G.J. Proarrhythmic effects of pinacidil are partially mediated through enhancement of catecholamine release in isolated perfused guinea-pig hearts. J Mol Cell Cardiol Feb 1998, 30(2):415-423.
48. Andersson K.E. Clinical pharmacology of potassium channel openers. Pharmacol Toxicol Apr 1992, 70(4):244-254.
49. Black S.C., Lucchesi B.R. Potassium channel openers are likely to be proarrhythmic in the diseased human heart. Cardiovasc Res Jun 1994, 28(6):923-924. discussion 6-9.
50. D'Alonzo A.J., Grover G.J. Potassium channel openers are unlikely to be proarrhythmic in the diseased human heart. Cardiovasc Res 1994 Jun, 28(6):924-925. discussion 6-9.
51. Billman G.E., Avendano C.E., Halliwill J.R., Burroughs J.M. The effects of the ATP-dependent potassium channel antagonist, glyburide, on coronary blood flow and susceptibility to ventricular fibrillation in unanesthetized dogs. J Cardiovasc Pharmacol Feb 1993, 21(2):197-204.
52. Cacciapuoti F., Spiezia R., Bianchi U., Lama D., D'Avino M., Varricchio M. Effectiveness of glibenclamide on myocardial ischemic ventricular arrhythmias in non-insulin-dependent diabetes mellitus. Am J Cardiol Apr 15 1991, 67(9):843-847.
53. Lomuscio A., Vergani D., Marano L., Castagnone M., Fiorentini C. Effects of glibenclamide on ventricular fibrillation in non-insulin-dependent diabetics with acute myocardial infarction. Coron Artery Dis Sep 1994, 5(9):767-771.
54. Elrod J.W., Harrell M., Flagg T.P., Gundewar S., Magnuson M.A., Nichols C.G., et al. Role of sulfonylurea receptor type 1 subunits of ATP-sensitive potassium channels in myocardial ischemia/reperfusion injury. Circulation Mar 18 2008, 117(11):1405-1413.