Recirculating cardiac delivery of AAV2/1SERCA2a improves myocardial function in an experimental model of heart failure in large animals

Gene Therapy

Volumn 15, Issue 23, 2008, Pages 1550-1557

  Byrne, M J ^a   Power, J M ^a   Preovolos, A ^a   Mariani, J A ^a   Hajjar, R J ^b,c   Kaye, D M ^a  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c Celladon Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN NATRIURETIC PEPTIDE; PARVOVIRUS VECTOR; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE 2A; UNCLASSIFIED DRUG;

ADENO ASSOCIATED VIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MEGADOSE; ECHOCARDIOGRAPHY; GENE EXPRESSION; GENE FUNCTION; GENE SEQUENCE; HEART FAILURE; HEART FUNCTION; HEART HEMODYNAMICS; HEART LEFT VENTRICLE PRESSURE; HISTOPATHOLOGY; LOW DRUG DOSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RNA EXTRACTION; SEQUENCE ANALYSIS; SHEEP; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; CARDIAC PACING, ARTIFICIAL; CORONARY CIRCULATION; DEPENDOVIRUS; DOSE-RESPONSE RELATIONSHIP, DRUG; ECHOCARDIOGRAPHY; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; HEART FAILURE; LIVER; LUNG; MODELS, ANIMAL; MYOCARDIUM; POLYMERASE CHAIN REACTION; RANDOM ALLOCATION; RNA, MESSENGER; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SHEEP; TIME; TRANSDUCTION, GENETIC; TRANSGENES;

ADENO-ASSOCIATED VIRUS - 2; ANIMALIA; OVIS ARIES;

EID: 56349118816     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2008.120     Document Type: Article

References (25)

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