Small amounts of α-myosin heavy chain isoform expression significantly increase power output of rat cardiac myocyte fragments

Circulation Research

Volumn 90, Issue 11, 2002, Pages 1150-1152

  Herron, Todd J ^a   McDonald, Kerry S ^a  

^a University of Missouri   (United States)

Author keywords

Cardiac myocytes; Myocardial performance; Myosin heavy chain; Power output; Sarcomeric proteins

Indexed keywords

MYOSIN HEAVY CHAIN;

ANIMAL CELL; ARTICLE; GENE EXPRESSION REGULATION; HEART CONTRACTION; HEART MUSCLE CELL; HEART OUTPUT; HEART PERFORMANCE; HEART STROKE VOLUME; MALE; NONHUMAN; PATHOPHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RAT;

ANIMALS; BIOMECHANICS; CELL SIZE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; MALE; MYOCARDIUM; MYOSIN HEAVY CHAINS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0037076795     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000022879.57270.11     Document Type: Article

References (17)

1. Molecular basis of cardiac performance: Plasticity of the myocardium generated through protein isoform switches
2. Expression of the β (slow)-isoform of MHC in the adult mouse heart causes dominant-negative functional effects
3. Full-length rat α and β cardiac myosin heavy chain sequences
4. Altered myosin isozyme patterns from pressure-overloaded and thyrotoxic hypertrophied rabbit hearts
5. Smooth, cardiac, and skeletal muscle myosin force and motion generation assessed by cross-bridge mechanical interactions in vitro
6. Loaded shortening and power output in cardiac myocytes are dependent on myosin heavy chain isoform expression
7. Expression of cardiac α- and β-myosin heavy chain genes is developmentally and hormonally regulated
8. Diabetes mellitus induces changes in cardiac myosin of the rat
9. Myosin heavy chain isoform expression in the failing and nonfailing human heart
10. Human cardiac myosin heavy chain isoforms in fetal and failing adult atria and ventricles
11. Role of myosin heavy chain composition in kinetics of force development and relaxation in rat myocardium
12. 2+-activated tension development in single adult cardiac myocytes
13. 2+ dependence of loaded shortening in rat skinned cardiac myocytes and skeletal muscle fibers
14. Structural interpretation of the mutations in the β-cardiac myosin that have been implicated in familial hypertrophic cardiomyopathy
15. Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy
16. 3 myosins differ in their hydrolytic and mechanical activities in vitro
17. Simulations predict that expression of small amounts of a-MHC in mammalian ventricles significantly accelerate the rate of rise of force