Interferon signaling

Signaling Pathways in Liver Diseases

Volumn , Issue , 2010, Pages 189-200

  Heim, Markus H ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84891432293     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-642-00150-5_12     Document Type: Chapter

References (111)

1. Isaacs A, Lindenmann J (1957) Virus interference. I. The interferon. In Proceedings of the Royal Society of London. Series B, Containing papers of a Biological character, vol 147, pp 258-267
2. Pestka S (2007) The interferons: 50 years after their discovery, there is much more to learn. J Biol Chem 282:20047-20051
3. Pestka S, Krause CD, Walter MR (2004) Interferons, interferonlike cytokines, and their receptors. Immunol Rev 202:8-32
4. Uze G, Lutfalla G, Gresser I (1990) Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA. Cell 60:225-234
5. Novick D, Cohen B, Rubinstein M (1994) The human interferon alpha/beta receptor: characterization and molecular cloning. Cell 77:391-400
6. Lutfalla G, Holland SJ, Cinato E et al (1995) Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster. Embo J 14:5100-5108
7. Aguet M, Dembic Z, Merlin G (1988) Molecular cloning and expression of the human interferon-gamma receptor. Cell 55:273-280
8. Soh J, Donnelly RJ, Kotenko S et al (1994) Identification and sequence of an accessory factor required for activation of the human interferon gamma receptor. Cell 76:793-802
9. Hemmi S, Bohni R, Stark G et al (1994) A novel member of the interferon receptor family complements functionality of the murine interferon gamma receptor in human cells. Cell 76:803-810
10. Coccia EM, Severa M, Giacomini E et al (2004) Viral infection and Toll-like receptor agonists induce a differential expression of type I and lambda interferons in human plasmacytoid and monocyte-derived dendritic cells. Eur J Immunol 34:796-805
11. Kotenko SV, Gallagher G, Baurin VV et al (2003) IFNlambdas mediate antiviral protection through a distinct class II cytokine receptor complex. Nat Immunol 4:69-77
12. Donnelly RP, Sheikh F, Kotenko SV et al (2004) The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain. J Leukoc Biol 76:314-321
13. Iwasaki A, Medzhitov R (2004) Toll-like receptor control of the adaptive immune responses. Nat Immunol 5:987-995
14. Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124:783-801
15. Yoneyama M, Fujita T (2007) Function of RIG-I-like receptors in antiviral innate immunity. J Biol Chem 282:15315-15318
16. Yoneyama M, Kikuchi M, Natsukawa T et al (2004) The RNA helicase RIG-I has an essential function in doublestranded RNA-induced innate antiviral responses. Nat Immunol 5:730-737
17. Alexopoulou L, Holt AC, Medzhitov R et al (2001) Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413:732-738
18. Diebold SS, Kaisho T, Hemmi H et al (2004) Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303:1529-1531
19. Heil F, Hemmi H, Hochrein H et al (2004) Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 303:1526-1529
20. Bauer S, Kirschning CJ, Hacker H et al (2001) Human TLR9 confers responsiveness to bacterial DNA via speciesspecific CpG motif recognition. Proc Natl Acad Sci U S A 98:9237-9242
21. Sato M, Suemori H, Hata N et al (2000) Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction. Immunity 13:539-548
22. Marie I, Durbin JE, Levy DE (1998) Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7. EMBO J 17:6660-6669
23. Kawai T, Sato S, Ishii KJ et al (2004) Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol 5:1061-1068
24. Honda K, Yanai H, Mizutani T et al (2004) Role of a transductionaltranscriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling. Proc Natl Acad Sci U S A 101:15416-15421
25. Hoshino K, Sugiyama T, Matsumoto M et al (2006) IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9. Nature 440:949-953
26. Xu LG, Wang YY, Han KJ et al (2005) VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol Cell 19:727-740
27. Meylan E, Curran J, Hofmann K et al (2005) Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437:1167-1172
28. Seth RB, Sun L, Ea CK et al (2005) Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell 122:669-682
29. Kawai T, Takahashi K, Sato S et al (2005) IPS-1, an adaptor triggering RIG-I-and Mda5-mediated type I interferon induction. Nat Immunol 6:981-988
30. Darnell JE Jr (1997) STATs and gene regulation. Science 277:1630-1635
31. Darnell JE Jr, Kerr IM, Stark GR (1994) Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415-1421
32. Heim MH (2003) The STAT protein family. In: Sehgal PB, Levy DE, Hirano T (eds) Signal Transducers and Activators of Transcription (STATs). Activation and Biology. Kluwer, Dordrecht
33. Mertens C, Zhong M, Krishnaraj R et al (2006) Dephosphorylation of phosphotyrosine on STAT1 dimers requires extensive spatial reorientation of the monomers facilitated by the N-terminal domain. Genes Dev 20:3372-3381
34. Vinkemeier U, Moarefi I, Darnell JE Jr et al (1998) Structure of the amino-terminal protein interaction domain of STAT-4. Science 279:1048-1052
35. Heim MH, Kerr IM, Stark GR et al (1995) Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway. Science 267:1347-1349
36. Schaefer TS, Sanders LK, Nathans D (1995) Cooperative transcriptional activity of Jun. and Stat3 beta, a short form of Stat3. Proc Natl Acad Sci U S A 92:9097-9101
37. Zhang X, Wrzeszczynska MH, Horvath CM et al (1999) Interacting regions in Stat3 and c-Jun. that participate in cooperative transcriptional activation. Mol Cell Biol 19:7138-7146
38. Krebs DL, Hilton DJ (2001) SOCS proteins: negative regulators of cytokine signaling. Stem Cells 19:378-387
39. Song MM, Shuai K (1998) The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities. J Biol Chem 273:35056-35062
40. Sakamoto H, Kinjyo I, Yoshimura A (2000) The janus kinase inhibitor, Jab/SOCS-1, is an interferon-gamma inducible gene and determines the sensitivity to interferons. Leuk Lymphoma 38:49-58
41. Alexander WS, Starr R, Fenner JE et al (1999) SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell 98:597-608
42. Fenner JE, Starr R, Cornish AL et al (2006) Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity. Nat Immunol 7:33-39
43. Liu LQ, Ilaria R Jr, Kingsley PD et al (1999) A novel ubiquitinspecific protease, UBP43, cloned from leukemia fusion protein AML1-ETO-expressing mice, functions in hematopoietic cell differentiation. Mol Cell Biol 19:3029-3038
44. Malakhov MP, Malakhova OA, Kim KI et al (2002) UBP43 (USP18) specifically removes ISG15 from conjugated proteins. J Biol Chem 277:9976-9981
45. Malakhova OA, Kim KI, Luo JK et al (2006) UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity. Embo J 25:2358-2367
46. Ritchie KJ, Malakhov MP, Hetherington CJ et al (2002) Dysregulation of protein modification by ISG15 results in brain cell injury. Genes Dev 16:2207-2212
47. Malakhova OA, Yan M, Malakhov MP et al (2003) Protein ISGylation modulates the JAK-STAT signaling pathway. Genes Dev 17:455-460
48. Ritchie KJ, Hahn CS, Kim KI et al (2004) Role of ISG15 protease UBP43 (USP18) in innate immunity to viral infection. Nat Med 10:1374-1378
49. Liu B, Liao J, Rao X et al (1998) Inhibition of Stat1-mediated gene activation by PIAS1. Proc Natl Acad Sci U S A 95:10626-10631
50. Liu B, Mink S, Wong KA et al (2004) PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity. Nat Immunol 5:891-898
51. ten Hoeve J, de Jesus Ibarra-Sanchez M, Fu Y et al (2002) Identification of a nuclear Stat1 protein tyrosine phosphatase. Mol Cell Biol 22:5662-5668
52. Heinonen KM, Nestel FP, Newell EW et al (2004) T-cell protein tyrosine phosphatase deletion results in progressive systemic inflammatory disease. Blood 103:3457-3464
53. Larner AC, Chaudhuri A, Darnell JE Jr (1986) Transcriptional induction by interferon. New protein (s) determine the extent and length of the induction. J Biol Chem 261:453-459
54. Goh KC, Haque SJ, Williams BR (1999) p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons. EMBO J 18:5601-5608
55. Li Y, Sassano A, Majchrzak B et al (2004) Role of p38alpha Map kinase in Type I interferon signaling. J Biol Chem 279:970-979
56. Yang CH, Murti A, Pfeffer SR et al (2001) Interferon alpha/beta promotes cell survival by activating nuclear factor kappa B through phosphatidylinositol 3-kinase and Akt. J Biol Chem 276:13756-13761
57. Kaur S, Sassano A, Dolniak B et al (2008) Role of the Akt pathway in mRNA translation of interferon-stimulated genes. Proc Natl Acad Sci U S A 105:4808-4813
58. der SD, Zhou A, Williams BR et al (1998) Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays. Proc Natl Acad Sci U S A 95:15623-15628
59. de Veer MJ, Holko M, Frevel M et al (2001) Functional classification of interferon-stimulated genes identified using microarrays. J Leukoc Biol 69:912-920
60. Sarasin-Filipowicz M, Oakeley EJ, Duong FH et al (2008) Interferon signaling and treatment outcome in chronic hepatitis C. Proc Natl Acad Sci U S A 105:7034-7039
61. Lanford RE, Guerra B, Lee H et al (2006) Genomic response to interferon-alpha in chimpanzees: implications of rapid downregulation for hepatitis C kinetics. Hepatology 43:961-972
62. van Boxel-Dezaire AH, Rani MR, Stark GR (2006) Complex modulation of cell type-specific signaling in response to type I interferons. Immunity 25:361-372
63. Stetson DB, Medzhitov R (2006) Type I interferons in host defense. Immunity 25:373-381
64. Sadler AJ, Williams BR (2008) Interferon-inducible antiviral effectors. Nat Rev Immunol 8:559-568
65. Terenzi F, Hui DJ, Merrick WC et al (2006) Distinct induction patterns and functions of two closely related interferoninducible human genes, ISG54 and ISG56. J Biol Chem 281:34064-34071
66. Narasimhan J, Potter JL, Haas AL (1996) Conjugation of the 15-kDa interferon-induced ubiquitin homolog is distinct from that of ubiquitin. J Biol Chem 271:324-330
67. Zhao C, Denison C, Huibregtse JM et al (2005) Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways. Proc Natl Acad Sci U S A 102:10200-10205
68. Giannakopoulos NV, Luo JK, Papov V et al (2005) Proteomic identification of proteins conjugated to ISG15 in mouse and human cells. Biochem Biophys Res Commun 336:496-506
69. Yuan W, Krug RM (2001) Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitinlike ISG15 protein. EMBO J 20:362-371
70. Kim KI, Giannakopoulos NV, Virgin HW et al (2004) Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme for protein ISGylation. Mol Cell Biol 24:9592-9600
71. Zhao C, Beaudenon SL, Kelley ML et al (2004) The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein. Proc Natl Acad Sci U S A 101:7578-7582
72. Zou W, Zhang DE (2006) The interferon-inducible ubiquitinprotein isopeptide ligase (E3) EFP also functions as an ISG15 E3 ligase. J Biol Chem 281:3989-3994
73. Wong JJ, Pung YF, Sze NS et al (2006) HERC5 is an IFNinduced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets. Proc Natl Acad Sci U S A 103:10735-10740
74. Lenschow DJ, Lai C, Frias-Staheli N et al (2007) IFNstimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses. Proc Natl Acad Sci U S A 104:1371-1376
75. Arnheiter H, Skuntz S, Noteborn M et al (1990) Transgenic mice with intracellular immunity to influenza virus. Cell 62:51-61
76. Sheehy AM, Gaddis NC, Choi JD et al (2002) Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein. Nature 418:646-650
77. Helbig KJ, Lau DT, Semendric L et al (2005) Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector. Hepatology 42:702-710
78. Jiang D, Guo H, Xu C et al (2008) Identification of three interferon-inducible cellular enzymes that inhibit the replication of hepatitis C virus. J Virol 82:1665-1678
79. Stark GR, Kerr IM, Williams BR et al (1998) How cells respond to interferons. Annu Rev Biochem 67:227-264
80. Melamed D, Tiefenbrun N, Yarden A et al (1993) Interferons and interleukin-6 suppress the DNA-binding activity of E2F in growth-sensitive hematopoietic cells. Mol Cell Biol 13:5255-5265
81. Friedman RM (2008) Clinical uses of interferons. Br J Clin Pharmacol 65:158-162
82. Fried MW, Shiffman ML, Reddy KR et al (2002) Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 347:975-982
83. Manns MP, McHutchison JG, Gordon SC et al (2001) Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 358:958-965
84. Janssen HL, van Zonneveld M, Senturk H et al (2005) Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial. Lancet 365:123-129
85. Marcellin P, Lau GK, Bonino F et al (2004) Peginterferon alfa-2a alone, lamivudine alone, and the two in combination in patients with HBeAg-negative chronic hepatitis B. N Engl J Med 351:1206-1217
86. Randall RE, Goodbourn S (2008) Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. J Gen Virol 89:1-47
87. Weber F, Haller O (2007) Viral suppression of the interferon system. Biochimie 89:836-842
88. Feld JJ, Hoofnagle JH (2005) Mechanism of action of interferon and ribavirin in treatment of hepatitis C. Nature 436:967-972
89. Bode JG, Brenndorfer ED, Haussinger D (2008) Hepatitis C virus (HCV) employs multiple strategies to subvert the host innate antiviral response. Biol Chem 389:1283-1298
90. Bode JG, Ludwig S, Ehrhardt C et al (2003) IFN-alpha antagonistic activity of HCV core protein involves induction of suppressor of cytokine signaling-3. FASEB J 17:488-490
91. Kawaguchi T, Yoshida T, Harada M et al (2004) Hepatitis C virus down-regulates insulin receptor substrates 1 and 2 through up-regulation of suppressor of cytokine signaling 3. Am J Pathol 165:1499-1508
92. Lin W, Choe WH, Hiasa Y et al (2005) Hepatitis C virus expression suppresses interferon signaling by degrading STAT1. Gastroenterology 128:1034-1041
93. Melen K, Fagerlund R, Nyqvist M et al (2004) Expression of hepatitis C virus core protein inhibits interferon-induced nuclear import of STATs. J Med Virol 73:536-547
94. Heim MH, Moradpour D, Blum HE (1999) Expression of hepatitis C virus proteins inhibits signal transduction through the Jak-STAT pathway. J Virol 73:8469-8475
95. Blindenbacher A, Duong FH, Hunziker L et al (2003) Expression of hepatitis c virus proteins inhibits interferon alpha signaling in the liver of transgenic mice. Gastroenterology 124:1465-1475
96. Duong FH, Filipowicz M, Tripodi M et al (2004) Hepatitis C virus inhibits interferon signaling through up-regulation of protein phosphatase 2A. Gastroenterology 126:263-277
97. Christen V, Treves S, Duong FH et al (2007) Activation of endoplasmic reticulum stress response by hepatitis viruses up-regulates protein phosphatase 2A. Hepatology 46:558-565
98. Duong FH, Christen V, Berke JM et al (2005) Upregulation of protein phosphatase 2Ac by hepatitis C virus modulates NS3 helicase activity through inhibition of protein arginine methyltransferase 1. J Virol 79:15342-15350
99. Mowen KA, Tang J, Zhu W et al (2001) Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription. Cell 104:731-741
100. Meissner T, Krause E, Lodige I et al (2004) Arginine methylation of STAT1: a reassessment. Cell 119:587-589; discussion 589-590
101. Duong FH, Christen V, Filipowicz M et al (2006) S-adenosylmethionine and betaine correct hepatitis C virus induced inhibition of interferon signaling in vitro. Hepatology 43:796-806
102. Li K, Foy E, Ferreon JC et al (2005) Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc Natl Acad Sci U S A 102:2992-2997
103. Sumpter R Jr, Loo YM, Foy E et al (2005) Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I. J Virol 79:2689-2699
104. Bigger CB, Brasky KM, Lanford RE (2001) DNA microarray analysis of chimpanzee liver during acute resolving hepatitis C virus infection. J Virol 75:7059-7066
105. Bigger CB, Guerra B, Brasky KM et al (2004) Intrahepatic gene expression during chronic hepatitis C virus infection in chimpanzees. J Virol 78:13779-13792
106. Chen L, Borozan I, Feld J et al (2005) Hepatic gene expression discriminates responders and nonresponders in treatment of chronic hepatitis C viral infection. Gastroenterology 128:1437-1444
107. Asselah T, Bieche I, Narguet S et al (2008) Liver gene expression signature to predict response to pegylated interferon plus ribavirin combination therapy in patients with chronic hepatitis C. Gut 57:516-524
108. Foster GR, Ackrill AM, Goldin RD et al (1991) Expression of the terminal protein region of hepatitis B virus inhibits cellular responses to interferons alpha and gamma and doublestranded RNA. Proc Natl Acad Sci U S A 88:2888-2892
109. Christen V, Duong F, Bernsmeier C et al (2007) Inhibition of alpha interferon signaling by hepatitis B virus. J Virol 81:159-165
110. Kuo MY, Chao M, Taylor J (1989) Initiation of replication of the human hepatitis delta virus genome from cloned DNA: role of delta antigen. J Virol 63:1945-1950
111. Pugnale P, Pazienza V, Guilloux K et al (2009) Hepatitis delta virus inhibits alpha interferon signaling. Hepatology 49:398-406