-
1
-
-
0028117299
-
Cytokine therapeutics: Lessons from interferon-α
-
Gutterman, J.U. Cytokine therapeutics: Lessons from interferon-α. Proc. Natl. Acad. Sci. USA 91, 1198-1205 (1994).
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 1198-1205
-
-
Gutterman, J.U.1
-
2
-
-
0000520727
-
Virus interference I: The interferons
-
Issac, A. & Lindemann, J. Virus interference I: The interferons. Proc. Royal Soc. Lond. B 147, 258-267 (1957).
-
(1957)
Proc. Royal Soc. Lond. B
, vol.147
, pp. 258-267
-
-
Issac, A.1
Lindemann, J.2
-
3
-
-
0023159806
-
Interferons and their actions
-
Pestka, S., Langer, J.A., Zoon, K.C. & Samuel, C.E. Interferons and their actions. Annu. Rev. Biochem. 56, 727-777 (1987).
-
(1987)
Annu. Rev. Biochem.
, vol.56
, pp. 727-777
-
-
Pestka, S.1
Langer, J.A.2
Zoon, K.C.3
Samuel, C.E.4
-
4
-
-
0028271922
-
A gene on human chromosome 21 located in the region 21q22.2 to 22q22.3 encodes a factor necessary for signal transduction and antiviral response to type I interferons
-
Hertzog, P.J, et al. A gene on human chromosome 21 located in the region 21q22.2 to 22q22.3 encodes a factor necessary for signal transduction and antiviral response to type I interferons. J. Biol. Chem. 269, 14088-14093 (1994).
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 14088-14093
-
-
Hertzog, P.J.1
-
6
-
-
0034855236
-
Type I interferons and limitin: A comparison of structures, receptors and functions
-
Oritani, K., Kincade, P.W., Zhang, C., Tomiyama, Y. & Matsuzuma, Y. Type I interferons and limitin: A comparison of structures, receptors and functions. Cytokine Growth Factor Rev. 12, 337-348 (2001).
-
(2001)
Cytokine Growth Factor Rev.
, vol.12
, pp. 337-348
-
-
Oritani, K.1
Kincade, P.W.2
Zhang, C.3
Tomiyama, Y.4
Matsuzuma, Y.5
-
7
-
-
0035030376
-
Type I interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo
-
Le Bon, A. et al. Type I interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo. Immunity 14, 461-470 (2001).
-
(2001)
Immunity
, vol.14
, pp. 461-470
-
-
Le Bon, A.1
-
8
-
-
0030889207
-
The IFN-γ receptor: A paradigm for cytokine receptor signaling
-
Bach, E.A., Aguet, M. & Schreiber, R.D. The IFN-γ receptor: A paradigm for cytokine receptor signaling. Annu. Rev. Immunol. 15, 563-591 (1997).
-
(1997)
Annu. Rev. Immunol.
, vol.15
, pp. 563-591
-
-
Bach, E.A.1
Aguet, M.2
Schreiber, R.D.3
-
9
-
-
0033662145
-
NKT cells: Facts, functions and fallacies
-
Godfrey, D.I., Hammond K.J.. Poulton, L.D., Smythe, M.J. & Baxter, A.G. NKT cells: Facts, functions and fallacies. Immunol. Today 21, 573-583 (2000).
-
(2000)
Immunol. Today
, vol.21
, pp. 573-583
-
-
Godfrey, D.I.1
Hammond, K.J.2
Poulton, L.D.3
Smythe, M.J.4
Baxter, A.G.5
-
10
-
-
0028234529
-
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
-
Darnell,J.E., Kerr, I.M. & Stark, G,R. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264, 1415-1421 (1994).
-
(1994)
Science
, vol.264
, pp. 1415-1421
-
-
Darnell, J.E.1
Kerr, I.M.2
Stark, G.R.3
-
11
-
-
0031657551
-
How cells respond to interferons
-
Stark, G.R., Kerr, I.M,, Williams, B.R., Silverman, R.H. & Schreiber, R.D., How cells respond to interferons. Annu. Rev. Biochem. 67, 227-264 (1998).
-
(1998)
Annu. Rev. Biochem.
, vol.67
, pp. 227-264
-
-
Stark, G.R.1
Kerr, I.M.2
Williams, B.R.3
Silverman, R.H.4
Schreiber, R.D.5
-
12
-
-
0020490033
-
How does interferon inhibit tumour growth?
-
Gresser, I. How does interferon inhibit tumour growth? Phil. Trans. R. Soc. Lond. B 299, 69-76 (1982).
-
(1982)
Phil. Trans. R. Soc. Lond. B
, vol.299
, pp. 69-76
-
-
Gresser, I.1
-
13
-
-
0030744134
-
Role of phosphatases in lymphocyte activation
-
Neel, B.G, Role of phosphatases in lymphocyte activation. Curr. Opin. Immunol. 9, 405-420 (1997).
-
(1997)
Curr. Opin. Immunol.
, vol.9
, pp. 405-420
-
-
Neel, B.G.1
-
14
-
-
0035905767
-
CD45 is a JAK phosphatase and negatively regulates cytokine receptor signaling
-
Irie-Sasaki, J. et al. CD45 is a JAK phosphatase and negatively regulates cytokine receptor signaling. Nature 409, 349-354 (2001).
-
(2001)
Nature
, vol.409
, pp. 349-354
-
-
Irie-Sasaki, J.1
-
15
-
-
0030792590
-
A family of cytokine-inducible inhibitors of signaling
-
Starr, R, et al. A family of cytokine-inducible inhibitors of signaling. Nature 387, 917-921 (1997).
-
(1997)
Nature
, vol.387
, pp. 917-921
-
-
Starr, R.1
-
16
-
-
0030839112
-
A new protein containing an SH2 domain that inhibits JAK kinases
-
Endo, T.A. et al. A new protein containing an SH2 domain that inhibits JAK kinases. Nature 387, 921-924 (1997).
-
(1997)
Nature
, vol.387
, pp. 921-924
-
-
Endo, T.A.1
-
17
-
-
0030755934
-
Structure and function of a new STAT-induced STAT inhibitor
-
Naka. T. et al. Structure and function of a new STAT-induced STAT inhibitor. Nature 387, 924-929 (1997).
-
(1997)
Nature
, vol.387
, pp. 924-929
-
-
Naka, T.1
-
18
-
-
0029014206
-
A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin-3 and erythropoietin receptors
-
Yoshimura, A. et al. A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin-3 and erythropoietin receptors. EMBO J. 14, 2816-2826 (1995).
-
(1995)
EMBO J.
, vol.14
, pp. 2816-2826
-
-
Yoshimura, A.1
-
19
-
-
13144258732
-
Twenty proteins containing a C-terminal SOCS box form five structural classes
-
Hilton, D.J. et al. Twenty proteins containing a C-terminal SOCS box form five structural classes. Proc. Natl. Acad. Sci. USA 95, 114-119 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 114-119
-
-
Hilton, D.J.1
-
20
-
-
0033555258
-
Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction
-
Nicholson, S.E. et al. Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction, EMBO J. 18, 375-385 (1999).
-
(1999)
EMBO J.
, vol.18
, pp. 375-385
-
-
Nicholson, S.E.1
-
21
-
-
0032803530
-
Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain
-
Sasaki, A. et al. Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain. Genes Cells 4, 339-351 (1999).
-
(1999)
Genes Cells
, vol.4
, pp. 339-351
-
-
Sasaki, A.1
-
22
-
-
13044263097
-
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation
-
Zhang, J.-G. et al. The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc. Natl. Acad. Sci. USA 96, 2071-2076 (1999).
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 2071-2076
-
-
Zhang, J.-G.1
-
23
-
-
0034612271
-
Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130
-
Nicholson, S.E. et al. Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130. Proc. Natl. Acad. Sci. USA 97. 6493-6498 (2000).
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 6493-6498
-
-
Nicholson, S.E.1
-
24
-
-
20244389693
-
The JAK binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop
-
Yasukawa, H. et al. The JAK binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J. 18, 1309-1320 (1999).
-
(1999)
EMBO J.
, vol.18
, pp. 1309-1320
-
-
Yasukawa, H.1
-
25
-
-
0036558025
-
The SOCS box: A tale of destruction and degradation
-
Kile, B.T. et al. The SOCS box: A tale of destruction and degradation. Trends Biochem. Sci. 27, 235-241 (2002).
-
(2002)
Trends Biochem. Sci.
, vol.27
, pp. 235-241
-
-
Kile, B.T.1
-
26
-
-
0031915126
-
Growth hormone preferentially induces the rapid, transient expression of SOCS3, a novel inhibitor of cytokine signaling
-
Adams, T.E. et al. Growth hormone preferentially induces the rapid, transient expression of SOCS3, a novel inhibitor of cytokine signaling. J. Biol. Chem. 273, 1285-1287 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 1285-1287
-
-
Adams, T.E.1
-
27
-
-
0032170490
-
A Janus kinase inhibitor, JAB, is an interferon-γ inducible gene and confers resistance to interferons
-
Sakamoto, H. et al. A Janus kinase inhibitor, JAB, is an interferon-γ inducible gene and confers resistance to interferons. Blood 92, 1668-1676 (1998).
-
(1998)
Blood
, vol.92
, pp. 1668-1676
-
-
Sakamoto, H.1
-
28
-
-
0032014178
-
Identification of SOCS3 as a potential mediator of central leptin resistance
-
Bjorbaek, C., Elmquist, J.K., Frantz, J.D., Shoelson, S.E. & Flier, J.S. Identification of SOCS3 as a potential mediator of central leptin resistance. Mol. Cell 1, 619-625 (1998).
-
(1998)
Mol. Cell
, vol.1
, pp. 619-625
-
-
Bjorbaek, C.1
Elmquist, J.K.2
Frantz, J.D.3
Shoelson, S.E.4
Flier, J.S.5
-
29
-
-
0032564463
-
Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1
-
Starr, R. et al. Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1. Proc. Natl. Acad. Sci. USA 95, 14395-14399 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 14395-14399
-
-
Starr, R.1
-
30
-
-
13044276245
-
Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice
-
Naka, T. et al. Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice. Proc. Natl. Acad. Sci. USA 95, 15577-15582 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 15577-15582
-
-
Naka, T.1
-
31
-
-
29244480441
-
SOCS 1 is a critical inhibitor of interferon γ signaling and prevents the potentially fatal neonatal actions of this cytokine
-
Alexander, W.S. et al. SOCS 1 is a critical inhibitor of interferon γ signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell 98, 1-20 (1999).
-
(1999)
Cell
, vol.98
, pp. 1-20
-
-
Alexander, W.S.1
-
32
-
-
0033520467
-
SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality
-
Marine, J.C. et al. SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. Cell 98, 609-616 (1999).
-
(1999)
Cell
, vol.98
, pp. 609-616
-
-
Marine, J.C.1
-
33
-
-
0035933805
-
Suppressor of cytokine signaling 1 attenuates the duration of interferon gamma signal transduction in vitro and in vivo
-
Brysha, M. et al. Suppressor of cytokine signaling 1 attenuates the duration of interferon gamma signal transduction in vitro and in vivo. J. Biol. Chem. 276, 22086-22089 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 22086-22089
-
-
Brysha, M.1
-
34
-
-
0023726619
-
Interferons in rheumatoid arthritis: Alterations in production and response related to disease activity
-
Hertzog, P.J., Emery, P., Cheetham, B.F., Mackay, I.R. & Linnane, A.W. Interferons in rheumatoid arthritis: Alterations in production and response related to disease activity. Clin. Immunol. Immunopathol. 48, 192-201 (1988).
-
(1988)
Clin. Immunol. Immunopathol.
, vol.48
, pp. 192-201
-
-
Hertzog, P.J.1
Emery, P.2
Cheetham, B.F.3
Mackay, I.R.4
Linnane, A.W.5
-
35
-
-
0032567353
-
The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities
-
Song, M.M. & Shuai, K. The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities. J. Biol. Chem. 273, 35056-35062 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 35056-35062
-
-
Song, M.M.1
Shuai, K.2
-
36
-
-
0346121599
-
Suppressors of cytokine signaling and immunity
-
Kubo, M., Hanada, T. & Yoshimura, A. Suppressors of cytokine signaling and immunity. Nat. Immunol. 4, 1169-1176 (2003).
-
(2003)
Nat. Immunol.
, vol.4
, pp. 1169-1176
-
-
Kubo, M.1
Hanada, T.2
Yoshimura, A.3
-
37
-
-
0034792866
-
Neutralisation of interferon-γ in neonatal Socs1 mice prevents fatty degeneration of the liver but not subsequent fatal inflammatory disease
-
Bullen, D.V., Darwiche, R., Metcalf, D., Handman, E. & Alexander, W.S. Neutralisation of interferon-γ in neonatal Socs1 mice prevents fatty degeneration of the liver but not subsequent fatal inflammatory disease. Immunology 104, 92-98 (2001).
-
(2001)
Immunology
, vol.104
, pp. 92-98
-
-
Bullen, D.V.1
Darwiche, R.2
Metcalf, D.3
Handman, E.4
Alexander, W.S.5
-
38
-
-
0038153864
-
The lethal effects of transplantation of Socs1 bone marrow cells into irradiated adult syngeneic recipients
-
Metcalf, D., Mifsud, S., Di Rage, L. & Alexander, W.S. The lethal effects of transplantation of Socs1 bone marrow cells into irradiated adult syngeneic recipients. Proc. Natl. Acad. Sci. USA 100, 8436-8441 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 8436-8441
-
-
Metcalf, D.1
Mifsud, S.2
Di Rage, L.3
Alexander, W.S.4
-
39
-
-
0027400726
-
Multiple defects of immune cell function in mice with disrupted interferon-γ genes
-
Dalton, D.K. et al. Multiple defects of immune cell function in mice with disrupted interferon-γ genes. Science 259, 1739-1742 (1993).
-
(1993)
Science
, vol.259
, pp. 1739-1742
-
-
Dalton, D.K.1
-
40
-
-
0028029170
-
Cytokines in the generation of immune responses to, and resolution of, virus infection
-
Biron, C.A. Cytokines in the generation of immune responses to, and resolution of, virus infection. Curr. Opin. Immunol. 6, 530-538 (1994).
-
(1994)
Curr. Opin. Immunol.
, vol.6
, pp. 530-538
-
-
Biron, C.A.1
-
41
-
-
0028070714
-
Functional role of type I and type II interferons in antiviral defense
-
Müller, U. et al. Functional role of type I and type II interferons in antiviral defense. Science 264, 1918-1921 (1994).
-
(1994)
Science
, vol.264
, pp. 1918-1921
-
-
Müller, U.1
-
42
-
-
0028864798
-
A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons α and β and alters macrophage responses
-
Hwang, S.Y. et al. A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons α and β and alters macrophage responses. Proc. Natl. Acad. Sci. USA 92, 11284-11288 (1995).
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 11284-11288
-
-
Hwang, S.Y.1
-
43
-
-
0038807434
-
Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling 1
-
Eyles, J.L., Metcalf, D., Grusby, M.J., Hilton, D.J. & Starr, R. Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling 1. J. Biol. Chem. 277, 43735-43740 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 43735-43740
-
-
Eyles, J.L.1
Metcalf, D.2
Grusby, M.J.3
Hilton, D.J.4
Starr, R.5
-
44
-
-
0030001830
-
Endogenous IFNα/β suppresses colony-stimulating factor (CSF)- 1-stimulated macrophage DNA synthesis and mediates inhibitory effects of lipopolysaccharide and TNFα
-
Hamilton, J.A., Whitty, G.A., Kola, I. & Hertzog, P.J. Endogenous IFNα/ β suppresses colony-stimulating factor (CSF) -1-stimulated macrophage DNA synthesis and mediates inhibitory effects of lipopolysaccharide and TNFα. J. Immunol. 156, 2553-2557 (1996).
-
(1996)
J. Immunol.
, vol.156
, pp. 2553-2557
-
-
Hamilton, J.A.1
Whitty, G.A.2
Kola, I.3
Hertzog, P.J.4
-
45
-
-
0141670818
-
The interferon in TLR signaling: More than just antiviral
-
Hertzog, P.J., O'Neill, L.A. & Hamilton, J.A. The interferon in TLR signaling: More than just antiviral. Trends Immunol. 24, 534-539 (2003).
-
(2003)
Trends Immunol.
, vol.24
, pp. 534-539
-
-
Hertzog, P.J.1
O'Neill, L.A.2
Hamilton, J.A.3
-
46
-
-
0034733672
-
Cross talk between interferon-γ and -α/β signaling components in caveolar membrane domains
-
Takaoka, A. et al. Cross talk between interferon-γ and -α/β signaling components in caveolar membrane domains. Science 288, 2357-2360 (2000).
-
(2000)
Science
, vol.288
, pp. 2357-2360
-
-
Takaoka, A.1
-
47
-
-
0037927824
-
Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other γc-dependent cytokines in peripheral T cells
-
Cornish, A.L. et al. Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other γc-dependent cytokines in peripheral T cells. J. Biol. Chem. 278, 22755-22761 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 22755-22761
-
-
Cornish, A.L.1
-
48
-
-
0037396793
-
+ T cell differentiation
-
+ T cell differentiation. Immunity 18, 475-487 (2003).
-
(2003)
Immunity
, vol.18
, pp. 475-487
-
-
Chong, M.M.1
-
49
-
-
0035336425
-
A novel pathway regulating lipopolysaccharide-Induced shock by ST2/T1 via inhibition of Toll-like receptor 4 expression
-
Sweet, M.J. et al. A novel pathway regulating lipopolysaccharide-Induced shock by ST2/T1 via inhibition of Toll-like receptor 4 expression. J. Immunol. 166, 6633-6639 (2001).
-
(2001)
J. Immunol.
, vol.166
, pp. 6633-6639
-
-
Sweet, M.J.1
-
50
-
-
0035219895
-
Isolation of embryonic fibroblasts and their use in the in vitro characterization of gene function
-
Hertzog, P.J. Isolation of embryonic fibroblasts and their use in the in vitro characterization of gene function. Methods Mol. Biol. 158, 205-215 (2001).
-
(2001)
Methods Mol. Biol.
, vol.158
, pp. 205-215
-
-
Hertzog, P.J.1
-
51
-
-
22144465860
-
A critical function for type I interferons in cancer immunoediting
-
Dunn, G.P. et al. A critical function for type I interferons in cancer immunoediting. Nat. Immunol. 6, 722-729 (2005).
-
(2005)
Nat. Immunol.
, vol.6
, pp. 722-729
-
-
Dunn, G.P.1
-
52
-
-
0041384326
-
Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity
-
Wilson-Annon, J. et al. Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity. J. Cell. Biol. 162, 877-887 (2003).
-
(2003)
J. Cell. Biol.
, vol.162
, pp. 877-887
-
-
Wilson-Annon, J.1
|