Inhibition of alpha interferon signaling by hepatitis B virus

Journal of Virology

Volumn 81, Issue 1, 2007, Pages 159-165

  Christen, Verena ^a   Duong, Francois ^a   Bernsmeier, Christine ^a   Sun, Dianxing ^b   Nassal, Michael ^b   Heim, Markus H ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; GENOMIC DNA; HEPATITIS B SURFACE ANTIGEN; PEGINTERFERON ALPHA2A; PHOSPHOPROTEIN PHOSPHATASE 2A; RNA; STAT1 PROTEIN;

ARTICLE; CHRONIC HEPATITIS; CONTROLLED STUDY; HEPATITIS B; HEPATITIS B VIRUS; HEPATITIS C; HUMAN; HUMAN CELL; LIVER BIOPSY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIRUS HEPATITIS; VIRUS RESISTANCE;

CELL LINE; DRUG RESISTANCE, VIRAL; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HEPATITIS B VIRUS; HUMANS; INTERFERON-ALPHA; METHYLATION; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; PROTEIN-ARGININE N-METHYLTRANSFERASE; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; UP-REGULATION; VIRAL PROTEINS;

HEPATITIS B VIRUS; HEPATITIS C VIRUS;

EID: 33845770748     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.01292-06     Document Type: Article

References (32)

1. Birnbaum, F., and M. Nassal. 1990. Hepatitis B virus nucleocapsid assembly: primary structure requirements in the core protein. J. Virol. 64:3319-3330.
2. Biron, C. A., and G. C. Sen. 2001. Interferons and other cytokines, p. 321-351. In D. M. Knipe and P. M. Howley (ed.), Fundamental virology, 4th ed. Lippincott Williams & Wilkins, Philadelphia, PA.
3. Blindenbacher, A., F. H. Duong, L. Hunziker, S. T. Stutvoet, X. Wang, L. Terracciano, D. Moradpour, H. E. Blum, T. Alonzi, M. Tripodi, N. La Monica, and M. H. Heim. 2003. Expression of hepatitis C virus proteins inhibits interferon alpha signaling in the liver of transgenic mice. Gastroenterology 124:1465-1475.
4. Darnell, J. E., Jr., I. M. Kerr, and G. R. Stark. 1994. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415-1421.
5. Darnell, J. E., Jr. 1997. STATs and gene regulation. Science 277:1630-1635.
6. Duong, F. H., V. Christen, J. M. Berke, S. H. Penna, D. Moradpour, and M. H. Heim. 2005. Upregulation of protein phosphatase 2Ac by hepatitis C virus modulates NS3 helicase activity through inhibition of protein arginine methyltransferase 1. J. Virol. 79:15342-15350.
7. Duong, F. H., V. Christen, M. Filipowicz, and M. H. Heim. 2006. S-adenosylmethionine and betaine correct hepatitis C virus induced inhibition of interferon signaling in vitro. Hepatology 43:796-806.
8. Duong, F. H., M. Filipowicz, M. Tripodi, N. La Monica, and M. H. Heim. 2004. Hepatitis C virus inhibits interferon signaling through up-regulation of protein phosphatase 2A. Gastroenterology 126:263-277.
9. Durbin, J. E., R. Hackenmiller, M. C. Simon, and D. E. Levy. 1996. Targeted disruption of the mouse Stat1 results in compromised innate immunity to viral disease. Cell 84:443-450.
10. Gale, M., Jr., and E. M. Foy. 2005. Evasion of intracellular host defence by hepatitis C virus. Nature 436:939-945.
11. Galibert, F., E. Mandart, F. Fitoussi, P. Tiollais, and P. Charnay. 1979. Nucleotide sequence of the hepatitis B virus genome (subtype ayw) cloned in E. coli. Nature 281:646-650.
12. Gary, J. D., and S. Clarke. 1998. RNA and protein interactions modulated by protein arginine methylation. Prog. Nucleic Acid Res. Mol. Biol. 61:65-131.
13. Gossen, M., and H. Bujard. 1992. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA 89:5547-5551.
14. Haller, O., G. Kochs, and F. Weber. 2006. The interferon response circuit: induction and suppression by pathogenic viruses. Virology 344:119-130.
15. Heim, M. H., D. Moradpour, and H. E. Blum. 1999. Expression of hepatitis C virus proteins inhibits signal transduction through the Jak-STAT pathway. J. Virol. 73:8469-8475.
16. Ishak, K., A. Baptista, L. Bianchi, F. Callea, J. De Groote, F. Gudat, H. Denk, V. Desmet, G. Korb, R. N. MacSween, et al. 1995. Histological grading and staging of chronic hepatitis. J. Hepatol. 22:696-699.
17. Janssens, V., and J. Goris. 2001. Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem. J. 353:417-439.
18. Krebs, D. L., and D. J. Hilton. 2001. SOCS proteins: negative regulators of cytokine signaling. Stem Cells 19:378-387.
19. Lai, C. L., V. Ratziu, M. F. Yuen, and T. Poynard. 2003. Viral hepatitis B. Lancet 362:2089-2094.
20. Lau, G. K., T. Piratvisuth, K. X. Luo, P. Marcellin, S. Thongsawat, G. Cooksley, E. Gane, M. W. Fried, W. C. Chow, S. W. Paik, W. Y. Chang, T. Berg, R. Flisiak, P. McCloud, and N. Pluck. 2005. Peginterferon Alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B. N. Engl. J. Med. 352:2682-2695.
21. Lee, W. M. 1997. Hepatitis B virus infection. N. Engl. J. Med. 337:1733-1745.
22. Liu, B., J. Liao, X. Rao, S. A. Kushner, C. D. Chung, D. D. Chang, and K. Shuai. 1998. Inhibition of Stat1-mediated gene activation by PIAS1. Proc. Natl. Acad. Sci. USA 95:10626-10631.
23. Meraz, M. A., J. M. White, K. C. F. Sheehan, E. A. Bach, S. J. Rodig, A. S. Dighe, D. H. Kaplan, J. K. Riley, A. C. Greenlund, D. Campbell, K. Carvermoore, R. N. Dubois, R. Clark, M. Aguet, and R. D. Schreiber. 1996. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the Jak-Stat signaling pathway. Cell 84:431-442.
24. Millward, T. A., S. Zolnierowicz, and B. A. Hemmings. 1999. Regulation of protein kinase cascades by protein phosphatase 2A. Trends Biochem. Sci. 24:186-191.
25. Mowen, K. A., J. Tang, W. Zhu, B. T. Schurter, K. Shuai, H. R. Herschman, and M. David. 2001. Arginine methylation of STAT1 modulates IFN-α/β-induced transcription. Cell 104:731-741.
26. Sällberg, M., U. Ruden, B. Wahren, M. Noah, and L. O. Magnius. 1991. Human and murine B-cells recognize the HBeAg/beta (or HBe2) epitope as a linear determinant. Mol. Immunol. 28:719-726.
27. Shuai, K. 2000. Modulation of STAT signaling by STAT-interacting proteins. Oncogene 19:2638-2644.
28. Smith, J. J., K. P. Rucknagel, A. Schierhorn, J. Tang, A. Nemeth, M. Linder, H. R. Herschman, and E. Wahle. 1999. Unusual sites of arginine methylation in poly(A)-binding protein II and in vitro methylation by protein arginine methyltransferases PRMT1 and PRMT3. J. Biol. Chem. 274:13229-13234.
29. Sun, D., and M. Nassal. 2006. Stable HepG2- and Huh7-based human hepatoma cell lines for efficient regulated expression of infectious hepatitis B virus. J. Hepatol. 45:636-645.
30. ten Hoeve, J., M. de Jesus Ibarra-Sanchez, Y. Fu, W. Zhu, M. Tremblay, M. David, and K. Shuai. 2002. Identification of a nuclear Stat1 protein tyrosine phosphatase. Mol. Cell. Biol. 22:5662-5668.
31. Wang, H., Z. Q. Huang, L. Xia, Q. Feng, H. Erdjument-Bromage, B. D. Strahl, S. D. Briggs, C. D. Allis, J. Wong, P. Tempst, and Y. Zhang. 2001. Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. Science 293:853-857.
32. Weber, B., A. Bayer, P. Kirch, V. Schluter, D. Schlieper, and W. Melchior. 1999. Improved detection of hepatitis B virus surface antigen by a new rapid automated assay. J. Clin. Microbiol. 37:2639-2647.