Role of ISG15 protease UBP43 (USP18) in innate immunity to viral infection

Nature Medicine

Volumn 10, Issue 12, 2004, Pages 1374-1378

  Ritchie, Kenneth J ^a   Hahn, Chang S ^b   Kim, Keun Il ^a   Yan, Ming ^a   Rosario, Dabralee ^a   Li, Li ^b   De La Torre, Juan Carlos ^a   Zhang, Dong Er ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN ISG15; PROTEIN UBP43; PROTEINASE; UNCLASSIFIED DRUG; VIRUS RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; EMBRYO; ENCEPHALOMYELITIS; GENETIC CODE; HUMORAL IMMUNITY; IMMUNE RESPONSE; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; RNA REPLICATION; VESICULAR STOMATITIS VIRUS; VIRUS INFECTION; VIRUS MENINGITIS; VIRUS REPLICATION;

ANIMALS; ANTIGENS, VIRAL; BLOTTING, NORTHERN; BLOTTING, WESTERN; BRAIN; CYTOKINES; ENDOPEPTIDASES; FIBROBLASTS; HUMANS; IMMUNITY, NATURAL; IMMUNOHISTOCHEMISTRY; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MACROPHAGES; MICE; RNA; T-LYMPHOCYTES; UBIQUITINS; VESICULAR STOMATITIS-INDIANA VIRUS; VIRUS REPLICATION;

ANIMALIA; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; RNA VIRUSES; SINDBIS VIRUS; VESICULAR STOMATITIS VIRUS;

EID: 11144294823     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1133     Document Type: Article

References (30)

1. Biron, C.A. Initial and innate responses to viral infections-pattern setting in immunity or disease. Curr. Opin. Microbiol. 2, 374-381 (1999).
2. Farrell, P.J., Broeze, R.J. & Lengyel, P. Accumulation of an mRNA and protein in interferon-treated Ehrlich ascites tumour cells. Nature 279, 523-525 (1979).
3. Haas, A.L., Ahrens, P., Bright, P.M. & Ankel, H. Interferon induces a 15-kilodalton protein exhibiting marked homology to ubiquitin. J. Biol. Chem. 262, 11315-11323 (1987).
4. Kim, K.I. & Zhang, D.E. ISG15, not just another ubiquitin-like protein. Biochem. Biophys. Res. Commun. 307, 431-434 (2003).
5. Malakhov, M.P., Malakhova, O.A., Kim, K.I., Ritchie, K.J. & Zhang, D.E. UBP43 (USP18) specifically removes ISG15 from conjugated proteins. J. Biol. Chem. 277, 9976-9981 (2002).
6. Ritchie, K.J. et al. Dysregulation of protein modification by ISG15 results in brain cell injury. Genes Dev. 16, 2207-2212 (2002).
7. Merigan, T.C., Oldstone, M.B. & Welsh, R.M. Interferon production during lymphocytic choriomeningitis virus infection of nude and normal mice. Nature 268, 67-68 (1977).
8. Leist, T.P. et al. Lack of correlation between serum titres of interferon alpha, beta, natural killer cell activity and clinical susceptibility in mice infected with two isolates of lymphocytic choriomeningitis virus. J. Gen. Virol. 68, 2213-2218 (1987).
9. Loeb, K.R. & Haas, A.L. The interferon-inducible 15-kDa ubiquitin homolog conjugates to intracellular proteins. J. Biol. Chem. 267, 7806-7813 (1992).
10. Ritchie, K.J. & Zhang, D.E. ISG15: the immunological kin of ubiquitin. Semin. Cell Dev. Biol. 15, 237-246 (2004).
11. McGavern, D.B., Homann, D. & Oldstone, M.B. T cells in the central nervous system: the delicate balance between viral clearance and disease. J. Infect. Dis. 186 Suppl 2, S145-S151 (2002).
12. Buchmeier, M.J., Bowen, M.D. & Peters, C.J. in Fields Virology. (eds. Knipe, D. & Howley, P.) Ch. 50, 1635-1668 (Lippincott Williams & Wilkins, Philadelphia, 2000).
13. Doherty, P.C. Cell-mediated immunity in virus infections of the central nervous system. Ann. NY Acad. Sci. 540, 228-239 (1988).
14. Malakhov, M.P. et al. High-throughput immunoblotting. Ubiquitiin-like protein ISG15 modifies key regulators of signal transduction. J. Biol. Chem. 278, 16608-16613 (2003).
15. Gresser, I. & Enders, J.F. Alteration of cellular resistance to Sindbis virus in mixed cultures of human cells attributable to interferon. Virology 16, 428-435 (1962).
16. Ito, Y. & Montagnier, L. Heterogeneity of the sensitivity of vesicular stomatitis virus to interferons. Infect. Immun. 18, 23-27 (1977).
17. Pfau, C.J., Gresser, I. & Hunt, K.D. Lethal role of interferon in lymphocytic choriomeningitis virus-induced encephalitis. J. Gen. Virol. 64, 1827-1830 (1983).
18. Cousens, L.P. et al. Two roads diverged: interferon alpha/beta- and interleukin 12-mediated pathways in promoting T cell interferon gamma responses during viral infection. J. Exp. Med. 189, 1315-1328 (1999).
19. Ou, R., Zhou, S., Huang, L. & Moskophidis, D. Critical role for alpha/beta and gamma interferons in persistence of lymphocytic choriomeningitis virus by clonal exhaustion of cytotoxic T cells. J. Virol. 75, 8407-8423 (2001).
20. Yuan, W. & Krug, R.M. Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein. EMBO J. 20, 362-371 (2001).
21. Malakhova, O.A. et al. Protein ISGylation modulates the JAK-STAT signaling pathway. Genes Dev. 17, 455-460 (2003).
22. Hamerman, J.A. et al. Serpin 2a is induced in activated macrophages and conjugates to a ubiquitin homolog. J. Immunol. 168, 2415-2423 (2002).
23. Darnell, J.E., Jr, Kerr, I.M. & Stark, G.R. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264, 1415-1421 (1994).
24. Muller, U. et al. Functional role of type I and type II interferons in antiviral defense. Science 264, 1918-1921 (1994).
25. Dutko, F.J. & Oldstone, M.B. Genomic and biological variation among commonly used lymphocytic choriomeningitis virus strains. J. Gen. Virol. 64, 1689-1698 (1983).
26. Holland, J.J. et al. Virus mutation frequencies can be greatly underestimated by monoclonal antibody neutralization of virions. J. Virol. 63, 5030-5036 (1989).
27. Hahn, Y.S., Guanzon, A., Rice, C.M. & Hahn, C.S. Class I MHC molecule-mediated inhibition of Sindbis virus replication. J. Immunol. 162, 69-77 (1999).
28. Pinschewer, D.D., Perez, M., Sanchez, A.B. & de la Torre, J.C. Recombinant lymphocytic choriomeningitis virus expressing vesicular stomatitis virus glycoprotein. Proc. Natl. Acad. Sci. USA 100, 7895-7900 (2003).
29. Lewicki, H. et al. CTL escape viral variants. I. Generation and molecular characterization. Virology 210, 29-40 (1995).
30. Homann, D. et al. Evidence for an underlying CD4 helper and CD8 T-cell defect in B-cell-deficient mice: failure to clear persistent virus infection after adoptive immunotherapy with virus-specific memory cells from muMT/muMT mice. J. Virol. 72, 9208-9216 (1998).