Upregulation of protein phosphatase 2Ac by hepatitis C virus modulates NS3 helicase activity through inhibition of protein arginine methyltransferase 1

Journal of Virology

Volumn 79, Issue 24, 2005, Pages 15342-15350

  Duong, Francois H T ^a   Christen, Verena ^a   Berke, Jan Martin ^b   Penna, Sabina Hernandez ^a   Moradpour, Darius ^c   Heim, Markus H ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b UNIVERSITY OF FREIBURG   (Germany)

^c LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ANTIVIRUS AGENT; ARGININE; HELICASE; INTERFERON; NONSTRUCTURAL PROTEIN 3; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE 2A; POLYPROTEIN; PROTEIN ARGININE METHYLTRANSFERASE; PROTEINASE; RNA HELICASE; SERINE PROTEINASE; STAT1 PROTEIN; VIRUS PROTEIN; VIRUS RNA;

ANIMAL CELL; ARTICLE; AUTORADIOGRAPHY; ELECTROPHORETIC MOBILITY; ENZYME ACTIVITY; ENZYME INHIBITION; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOPRECIPITATION; LIVER BIOPSY; METHYLATION; MOUSE; NONHUMAN; NORTHERN BLOTTING; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPLICON; UPREGULATION; VIRUS GENOME; WESTERN BLOTTING;

CELL LINE; HEPACIVIRUS; HUMANS; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN-ARGININE N-METHYLTRANSFERASE; RNA HELICASES; UP-REGULATION; VIRAL NONSTRUCTURAL PROTEINS;

ANIMALIA; HEPATITIS C VIRUS; MUS MUSCULUS;

EID: 29744450126     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.79.24.15342-15350.2005     Document Type: Article

References (35)

1. Baharians, Z., and A. H. Schonthal. 1998. Autoregulation of protein phosphatase type 2A expression. J. Biol. Chem. 273:19019-19024.
2. Biron, C. A., and G. C. Sen. 2001. Interferons and other cytokines, p. 321-351. In D. M. Knipe and P. M. Howley (ed.), Fundamental virology, 4th ed. Lippincott Williams & Wilkins, Philadelphia, Pa.
3. Blight, K. J., A. A. Kolykhalov, and C. M. Rice. 2000. Efficient initiation of HCV RNA replication in cell culture. Science 290:1972-1974.
4. Blight, K. J., J. A. McKeating, and C. M. Rice. 2002. Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication. J. Virol. 76:13001-13014.
5. Blindenbacher, A., F. H. Duong, L. Hunziker, S. T. Stutvoet, X. Wang, L. Terracciano, D. Moradpour, H. E. Blum, T. Alonzi, M. Tripodi, N. La Monica, and M. H. Heim. 2003. Expression of hepatitis c virus proteins inhibits interferon alpha signaling in the liver of transgenic mice. Gastroenterology 124:1465-1475.
6. Carroll, S. S., J. E. Tomassini, M. Bosserman, K. Getty, M. W. Stahlhut, A. B. Eldrup, B. Bhat, D. Hall, A. L. Simcoe, R. LaFemina, C. A. Rutkowski, B. Wolanski, Z. Yang, G. Migliaccio, R. De Francesco, L. C. Kuo, M. MacCoss, and D. B. Olsen. 2003. Inhibition of hepatitis C virus RNA replication by 2′-modified nucleoside analogs. J. Biol. Chem. 278:11979-11984.
7. Darnell, J. E., Jr., I. M. Kerr, and G. R. Stark. 1994. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415-1421.
8. Darnell, J. E., Jr. 1997. STATs and gene regulation. Science 277:1630-1635.
9. Di Bisceglie, A. M. 2000. Natural history of hepatitis C: its impact on clinical management. Hepatology 31:1014-1018.
10. Duong, F. H., M. Filipowicz, M. Tripodi, N. La Monica, and M. H. Heim. 2004. Hepatitis C virus inhibits interferon signaling through up-regulation of protein phosphatase 2A. Gastroenterology 126:263-277.
11. Durbin, J. E., R. Hackenmiller, M. C. Simon, and D. E. Levy. 1996. Targeted disruption of the mouse Stat1 results in compromised innate immunity to viral disease. Cell 84:443-450.
12. Fort, P., L. Marty, M. Piechaczyk, S. el Sabrouty, C. Dani, P. Jeanteur, and J. M. Blanchard. 1985. Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family. Nucleic Acids Res. 13:1431-1442.
13. Frick, D. N., R. S. Rypma, A. M. Lam, and B. Gu. 2004. The nonstructural protein 3 protease/helicase requires an intact protease domain to unwind duplex RNA efficiently. J. Biol. Chem. 279:1269-1280.
14. Heim, M. H., D. Moradpour, and H. E. Blum. 1999. Expression of hepatitis C virus proteins inhibits signal transduction through the Jak-STAT pathway. J. Virol. 73:8469-8475.
15. Janssens, V., and J. Goris. 2001. Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem. J. 353:417-439.
16. Kim, D. W., J. Kim, Y. Gwack, J. H. Han, and J. Choe. 1997. Mutational analysis of the hepatitis C virus RNA helicase. J. Virol. 71:9400-9409.
17. Kiyosawa, K., T. Sodeyama, E. Tanaka, Y. Gibo, K. Yoshizawa, Y. Nakano, S. Furuta, Y. Akahane, K. Nishioka, R. H. Purcell, and H. J. Alter. 1990. Interrelationship of blood transfusion, non-A, non-B hepatitis and hepatocellular carcinoma: analysis by detection of antibody to hepatitis C virus. Hepatology 12:671-675.
18. Kolykhalov, A. A., E. V. Agapov, K. J. Blight, K. Mihalik, S. M. Feinstone, and C. M. Rice. 1997. Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA. Science 277:570-574.
19. Koonin, E. V. 1991. Similarities in RNA helicases. Nature 352:290.
20. Krebs, D. L., and D. J. Hilton. 2001. SOCS proteins: negative regulators of cytokine signaling. Stem Cells 19:378-387.
21. Kwong, A. D., J. L. Kim, and C. Lin. 2000. Structure and function of hepatitis C virus NS3 helicase. Curr. Top. Microbiol. Immunol. 242:171-196.
22. Lam, A. M., R. S. Rypma, and D. N. Frick. 2004. Enhanced nucleic acid binding to ATP-bound hepatitis C virus NS3 helicase at low pH activates RNA unwinding. Nucleic Acids Res. 32:4060-4070.
23. Lauer, G. M., and B. D. Walker. 2001. Hepatitis C virus infection. N. Engl. J. Med. 345:41-52.
24. Linder, P., P. F. Lasko, M. Ashburner, P. Leroy, P. J. Nielsen, K. Nishi, J. Schnier, and P. P. Slonimski. 1989. Birth of the D-E-A-D box. Nature 337:121-122.
25. Liu, B., J. Liao, X. Rao, S. A. Kushner, C. D. Chung, D. D. Chang, and K. Shuai. 1998. Inhibition of Stat1-mediated gene activation by P1AS1. Proc. Natl. Acad. Sci. USA 95:10626-10631.
26. Meraz, M. A., J. M. White, K. C. F. Sheehan, E. A. Bach, S. J. Rodig, A. S. Dighe, D. H. Kaplan, J. K. Riley, A. C. Greenlund, D. Campbell, K. Carvermoore, R. N. Dubois, R. Clark, M. Aguet, and R. D. Schreiber. 1996. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the Jak-Stat signaling pathway. Cell 84:431-442.
27. Millward, T. A., S. Zolnierowicz, and B. A. Hemmings. 1999. Regulation of protein kinase cascades by protein phosphatase 2A. Trends Biochem. Sci. 24:186-191.
28. Moradpour, D., P. Kary, C. M. Rice, and H. E. Blum. 1998. Continuous human cell lines inducibly expressing hepatitis C virus structural and non-structural proteins. Hepatology 28:192-201.
29. Moradpour, D., B. Wolk, A. Cerny, M. H. Heim, and H. E. Blum. 2001. Hepatitis C: a concise review. Minerva Med. 92:329-339.
30. Mowen, K. A., J. Tang, W. Zhu, B. T. Schurter, K. Shuai, H. R. Herschman, and M. David. 2001. Arginine methylation of stat1 modulates ifnalpha/beta-induced transcription. Cell 104:731-741.
31. Rho, J., S. Choi, Y. R. Seong, J. Choi, and D. S. Im. 2001. The arginine-1493 residue in QRRGRTGR1493G motif IV of the hepatitis C virus NS3 helicase domain is essential for NS3 protein methylation by the protein arginine methyltransferase 1. J. Virol. 75:8031-8044.
32. Schmidt-Mende, J., E. Bieck, T. Hugle, F. Penin, C. M. Rice, H. E. Blum, and D. Moradpour. 2001. Determinants for membrane association of the hepatitis C virus RNA-dependent RNA polymerase. J. Biol. Chem. 276:44052-44063.
33. Shuai, K. 2000. Modulation of STAT signaling by STAT-interacting proteins. Oncogene 19:2638-2644.
34. Sontag, E. 2001. Protein phosphatase 2A: the Trojan horse of cellular signaling. Cell Signal 13:7-16.
35. ten Hoeve, J., M. de Jesus Ibarra-Sanchez, Y. Fu, W. Zhu, M. Tremblay, M. David, and K. Shuai. 2002. Identification of a nuclear Stat1 protein tyrosine phosphatase. Mol. Cell. Biol. 22:5662-5668.