Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis

Cancer and Metastasis Reviews

Volumn 32, Issue 3-4, 2013, Pages 643-671

  Beauchemin, Nicole ^a,b   Arabzadeh, Azadeh ^a  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Biomarker; Carcinoembryonic antigen; CEA; CEACAM1; CEACAM6; Cell adhesion molecule; Immunity; Immunotherapy

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 1; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 16; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 18; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 19; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 20; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 21; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 3; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 4; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 5; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 6; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 7; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 8; CELL ADHESION MOLECULE; CELL SURFACE RECEPTOR; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; FIBROBLAST GROWTH FACTOR; GELATINASE B; INTERCELLULAR ADHESION MOLECULE 1; MACROPHAGE INFLAMMATORY PROTEIN 1; MACROPHAGE INFLAMMATORY PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE PHOSPHATASE SHP 1; PROTEIN TYROSINE PHOSPHATASE SHP 2; UNCLASSIFIED DRUG; UVOMORULIN; VASCULOTROPIN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANGIOGENESIS; B LYMPHOCYTE; BLADDER CANCER; BONE MARROW CELL; BREAST CANCER; CANCER GROWTH; CANCER RISK; CANCER SURVIVAL; CELL ENERGY; CELL PROLIFERATION; CHRONIC MYELOID LEUKEMIA; COLON CANCER; COLORECTAL CANCER; DEREGULATION; DOWN REGULATION; ENDOMETRIUM CANCER; GALLBLADDER CANCER; GENOMIC INSTABILITY; HUMAN; IMMUNITY; IMMUNOSURVEILLANCE; LEUKOCYTE; LUNG CANCER; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; MALIGNANT TRANSFORMATION; MELANOMA; METASTASIS; NATURAL KILLER CELL; NONHUMAN; OVARY CANCER; OVERALL SURVIVAL; PANCREAS CANCER; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REVIEW; STOMACH CANCER; T LYMPHOCYTE; THYROID CANCER;

ANIMALS; ANTIGENS, CD; CARCINOEMBRYONIC ANTIGEN; CELL ADHESION MOLECULES; CELL MEMBRANE; DISEASE PROGRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; GPI-LINKED PROTEINS; HUMANS; MOLECULAR TARGETED THERAPY; MULTIGENE FAMILY; NEOPLASM METASTASIS; NEOPLASMS; PROGNOSIS; PROTEIN BINDING;

EID: 84890442740     PISSN: 01677659     EISSN: 15737233     Source Type: Journal    
DOI: 10.1007/s10555-013-9444-6     Document Type: Review

References (239)

1. Gold, P., & Freedman, S. O. (1965). Specific carcinoembryonic antigens of the human digestive system. The Journal of Experimental Medicine, 122, 467-481.
2. von Kleist, S., Chavanel, G., & Burtin, P. (1972). Identification of an antigen from normal human tissue that crossreacts with the carcinoembryonic antigen. Proceedings of the National Academy of Sciences of the United States of America, 69, 2492-2494.
3. Mach, J. P., & Pusztaszeri, G. (1972). Carcinoembroynic sntigen (CEA): Demonstration of a partial identity between CEA and a normal glycoprotein. Immunochemistry, 9, 1031-1034.
4. MacSween, J. M., Warner, N. L., Bankhurst, A. D., & Mackay, I. R. (1972). Carcinoembryonic antigen in whole serum. British Journal of Cancer, 26(5), 356-360.
5. Sorokin, J. J., Sugarbaker, P. H., Zamcheck, N., Pisick, M., Kupchik, H. Z., & Moore, F. (1974). Serial carcinoembryonic antigen assays. Use in detection of cancer recurrence. Journal of the American Medical Association, 228(1), 49-53.
6. Shively, J. E., & Beatty, J. D. (1985). CEA-related antigens: Molecular biology and clinical significance. Critical Reviews in Oncology/Hematology, 2(4), 355-399.
7. Oikawa, S., Nakazato, H., & Kosaki, G. (1987). Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence. Biochemical and Biophysical Research Communications, 142(2), 511-518.
8. Zimmermann, W., Ortlieb, B., Friedrich, R., & von Kleist, S. (1987). Isolation and characterization of cDNA clones encoding the human carcinoembryonic antigen reveal a highly conserved repeating structure. Proceedings of the National Academy of Sciences of the United States of America, 84(9), 2960-2964.
9. Thompson, J. A., Pande, H., Paxton, R. J., Shively, L., Padma, A., Simmer, R. L., Todd, C. W., Riggs, A. D., & Shively, J. E. (1987). Molecular cloning of a gene belonging to the carcinoembryonic antigen gene family and discussion of a domain model. Proceedings of the National Academy of Sciences of the United States of America, 84(9), 2965-2969.
10. Beauchemin, N., Benchimol, S., Cournoyer, D., Fuks, A., & Stanners, C. P. (1987). Isolation and characterization of full-length functional cDNA clones for human carcinoembryonic antigen. Molecular and Cellular Biology, 7(9), 3221-3230.
11. Kuroki, M., Yamanaka, T., Matsuo, Y., Ohtani, T., Matsuo, Y., Minowada, J., Misumi, Y., Oikawa, S., Nakazato, H., & Matsuoka, Y. (1994). Characterization of a species of non-specific cross-reacting antigen (NCA) expressed by human monocytic cell lines: Structure and expression during cell differentiation. International Journal of Cancer, 56(6), 886-891.
12. Kuroki, M., Arakawa, F., Matsuo, Y., Oikawa, S., Nakazato, H., & Matsuoka, Y. (1991). Three novel molecular biliary glycoprotein cDNA isoforms deduced clones from a leukocyte library. Biochemical and Biophysical Research Communications, 176, 578-585.
13. Barnett, T. R., Kretschmer, A., Austen, D. A., Goebel, S. J., Hart, J. T., Elting, J. J., & Kamarck, M. E. (1989). Carcinoembryonic antigens: Alternative splicing accounts for the multiple mRNAs that code for novel members of the carcinoembryonic antigen family. The Journal of Cell Biology, 108, 267-276.
14. Hinoda, Y., Neumaier, M., Hefta, S. A., Drzeniek, Z., Wagener, C., Shively, L., Hefta, L. J. F., Shively, J. E., & Paxton, R. J. (1988). Molecular cloning of a cDNA coding for biliary glycoprotein I: Primary structure of a glycoprotein immunologically crossreactive with carcinoembryonic antigen. Proceedings of the National Academy of Sciences of the United States of America, 85, 6959-6963.
15. Beauchemin, N., Draber, P., Dveksler, G., Gold, P., Gray-Owen, S., Grunert, F., et al. (1999). Redefined nomenclature for members of the carcinoembryonic antigen family. Experimental Cell Research, 252(2), 243-249.
16. Kammerer, R., & Zimmermann, W. (2010). Coevolution of activating and inhibitory receptors within mammalian carcinoembryonic antigen families. BioMedCentral Biology, 8, 12-33.
17. Obrink, B. (1997). CEA adhesion molecules: Multifunctional proteins with signal-regulatory properties. Current Opinion in Cell Biology, 9(5), 616-626.
18. Kuespert, K., Pils, S., & Hauck, C. R. (2006). CEACAMs: Their role in physiology and pathophysiology. Current Opinion in Cell Biology, 18(5), 565-571.
19. Voges, M., Bachmann, V., Naujoks, J., Kopp, K., & Hauck, C. R. (2012). Extracellular IgC2 constant domains of CEACAMs mediate PI3K sensitivity during uptake of pathogens. PLoS One, 7(6), e39908.
20. Kammerer, R., Rüttiger, L., Riesenberg, R., Schäuble, C., Krupar, R., Kamp, A., Sunami, K., Eisenried, A., Hennenberg, M., Grunert, F., Bress, A., Battaglia, S., Schrewe, H., Knipper, M., Schneider, M. R., & Zimmermann, W. (2012). Loss of mammal-specific tectorial membrane component carcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies. Journal of Biological Chemistry, 287(26), 21584-21598.
21. McLellan, A. S., Fischer, B., Dveksler, G., Hori, T., Wynne, F., Ball, M., Okumura, K., Moore, T., & Zimmermann, W. (2005). Structure and evolution of the mouse pregnancy-specific glycoprotein (Psg) gene locus. BioMedCentral Genomics, 6, 4.
22. Waterhouse, R., Ha, C., & Dveksler, G. S. (2002). Murine CD9 is the receptor for pregnancy-specific glycoprotein 17. The Journal of Experimental Medicine, 195(2), 277-282.
23. Ha, C. T., Waterhouse, R., Wessells, J., Wu, J. A., & Dveksler, G. S. (2005). Binding of pregnancy-specific glycoprotein 17 to CD9 on macrophages induces secretion of IL-10, IL-6, PGE2, and TGF-beta1. Journal of Leukocyte Biology, 77(6), 948-957.
24. Horst, A. K., & Wagener, C. (2004). CEA-related CAMs. Human Experimental Pharmacology, 165, 283-341.
25. Gray-Owen, S. D., & Blumberg, R. S. (2006). CEACAM1: Contact-dependent control of immunity. Nature Reviews Immunology, 6, 433-446.
26. Hefta, S. A., Hefta, L. J., Lee, T. D., Paxton, R. J., & Shively, J. E. (1988). Carcinoembryonic antigen is anchored to membranes by covalent attachment to a glycosylphosphatidylinositol moiety: Identification of the ethanolamine linkage site. Proceedings of the National Academy of Sciences of the United States of America, 85(13), 4648-4652.
27. Sack, T. L., Gum, J. R., Low, M. G., & Kim, Y. S. (1988). Release of carcinoembryonic antigen from human colon cancer cells by phosphatidylinositol- specific phospholipase C. Journal of Clinical Investigation, 82(2), 586-593.
28. Naghibalhossaini, F., & Stanners, C. P. (2004). Minimal mutations are required to effect a radical change in function in CEA family members of the Ig superfamily. Journal of Cell Science, 117(5), 761-769.
29. Dery, K. J., Gaur, S., Gencheva, M., Yen, Y., Shively, J. E., & Gaur, R. K. (2011). Mechanistic control of carcinoembryonic antigen-related cell adhesion molecule-1 (CEACAM1) splice isoforms by the heterogeneous nuclear ribonuclear proteins hnRNP L, hnRNP A1, and hnRNPM. Journal of Biological Chemistry, 286(18), 16039-16051.
30. Turbide, C., Kunath, T., Daniels, E., & Beauchemin, N. (1997). Optimal ratios of biliary glycoprotein isoforms required for inhibition of colonic tumor cell growth. Cancer Research, 57(13), 2781-2788.
31. Gaur, S., Shively, J.E., Yen, Y., & Gaur, R.K. (2008). Altered splicing of CEACAM1 in breast cancer: Identification of regulatory sequences that control splicing of CEACAM1 into long or short cytoplasmic domain isoforms. Molecular Cancer, 7(46). doi: 10.1186/1476-4598-1187-1146.
32. Wang, L., Lin, S. H., Wu, W. G., Kemp, B. L., Walsh, G. L., Hong, W. K., & Mao, L. (2000). C-CAM1, a candidate tumor suppressor gene, is abnormally expressed in primary lung cancers. Clinical Cancer Research, 6(8), 2988-2993.
33. Markel, G., Achdout, H., Katz, G., Ling, K. L., Salio, M., Gruda, R., Gazit, R., Mizrahi, S., Hanna, J., Gonen-Gross, T., Arnon, T. I., Lieberman, N., Stren, N., Nachmias, B., Blumberg, R. S., Steuer, G., Blau, H., Cerundolo, V., Mussaffi, H., & Mandelboim, O. (2004). Biological function of the soluble CEACAM1 protein and implications in TAP2-deficient patients. European Journal of Immunology, 34(8), 2138-2148.
34. Draberova, L., Cerna, H., Brodska, H., Boubelik, M., Watt, S. M., Stanners, C. P., et al. (2000). Soluble isoforms of CEACAM1 containing the A2 domain: Increased serum levels in patients with obstructive jaundice and differences in 3-fucosyl-N-acetyl-lactosamine moiety. Immunology, 101(2), 279-287.
35. Markel, G., Ortenberg, R., Seidman, R., Sapoznik, S., Koren-Morag, N., Besser, M. J., Bar, J., Shapira, R., Kubi, A., Nardini, G., Tessone, A., Treves, A. J., Winkler, E., Orenstein, A., & Schachter, J. (2010). Systemic dysregulation of CEACAM1 in melanoma patients. Cancer Immunology, Immunotherapy, 59, 215-230.
36. Simeone, D. M., Baoan, J., Banerjee, M., Arumugham, T., Li, D., Anderson, M. A., Bamberger, A. M., Greenson, J., Brand, R. E., Ramachandran, V., & Logsdon, C. D. (2007). CEACAM1, a novel serum biomarker for pancreatic cancer. Pancreas, 34, 436-443.
37. Tilki, D., Singer, B. B., Shariat, S. F., Behrend, A., Fernando, M., Irmak, S., Buchner, A., Hooper, A. T., Stief, C. G., Reich, O., & Ergün, S. (2010). CEACAM1: A novel urinary marker for bladder cancer detection. European Urology, 57(4), 648-654.
38. Zhou, H., Fuks, A., Alcaraz, G., Bolling, T. J., & Stanners, C. P. (1993). Homophilic adhesion between Ig superfamily carcinoembryonic antigen molecules involves double reciprocal bonds. The Journal of Cell Biology, 122(4), 951-960.
39. Thompson, J. A., Grunert, F., & Zimmermann, W. (1991). Carcinoembryonic antigen gene family: Molecular biology and clinical perspectives. Journal of Clinical Laboratory Analysis, 5, 344-366.
40. Bjerner, J., Lebedin, Y., Bellanger, L., Kuroki, M., Shively, J. E., Varaas, T., Nustad, K., Hammarström, S., & Børmer, O. P. (2002). Protein epitopes in carcinoembryonic antigen. Report of the ISOBM TD8 workshop. Tumour Biology, 23(4), 249-262.
41. Nap, M., Mollgard, K., Burtin, P., & Fleuren, G. J. (1988). Immunohistochemistry of carcino-embryonic antigen in the embryo, fetus and adult. Tumour Biology, 9(2-3), 145-153.
42. Eades-Perner, A.-M., van der Putten, H., Hirth, A., Thompson, J., Neumaier, M., von Kleist, S., & Zimmermann, W. (1994). Mice transgenic for the human carcinoembryonic antigen gene maintain its spatiotemporal expression pattern. Cancer Research, 54, 4169-4176.
43. Hammarstrom, S. (1999). The carcinoembryonic antigen (CEA) family: Structures, suggested functions and expression in normal and malignant tissues. Seminars in Cancer Biology, 9, 67-81.
44. Jothy, S., Yuan, S. Y., & Shirota, K. (1993). Transcription of carcinoembryonic antigen in normal colon and colon carcinoma. In situ hybridization study and implication for a new in vivo functional model. American Journal of Pathology, 143(1), 250-257.
45. Kodera, Y., Isobe, K., Yamauchi, M., Satta, T., Hasegawa, T., Oikawa, S., Kondoh, K., Akiyama, S., Itoh, K., Nakashima, I., & Taakagi, H. (1993). Expression of carcinoembryonic antigen (CEA) and nonspecific crossreacting antigen (NCA) in gastrointestinal cancer; the correlation with degree of differentiation. British Journal of Cancer, 68(1), 130-136.
46. Tiernan, J. P., Perry, S. L., Verghese, E. T., West, N. P., Yeluri, S., Jayne, D. G., & Hughes, T. A. (2013). Carcinoembryonic antigen is the preferred biomarker for in vivo colorectal cancer targeting. British Journal of Cancer, 108(3), 662-667.
47. Saadatmand, S., de Kruijf, E. M., Sajet, A., Dekker-Ensink, N. G., van Nes, J. G., Putter, H., Smit, V. T., van de Velde, C. J., Liefers, G. J., & Kuppen, P. J. (2013). Expression of cell adhesion molecules and prognosis in breast cancer. British Journal of Surgery, 100(2), 252-260.
48. Scholzel, S., Zimmermann, W., Schwarzkopf, G., Grunert, F., Rogaczewski, B., & Thompson, J. (2000). Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas. American Journal of Pathology, 156(2), 595-605.
49. Berling, B., Kolbinger, F., Grunert, F., Thompson, J. A., Brombacher, F., Buchegger, F., von Kleist, S., & Zimmermann, W. (1990). Cloning of a carcinoembryonic antigen gene family member expressed in leukocytes of chronic myeloid leukemia patients and bone marrow. Cancer Research, 50(20), 6534-6539.
50. Hanenberg, H., Baumann, M., Quentin, I., Nagel, G., Grosse-Wilde, H., von Kleist, S., Gobel, U., Burdach, S., & Grunert, F. (1994). Expression of the CEA gene family members NCA-50/90 and NCA-160 (CD66) in childhood acute lymphoblastic leukemias (ALLs) and in cell lines of B-cell origin. Leukemia, 8(12), 2127-2133.
51. Jantscheff, P., Terracciano, L., Lowy, A., Glatz-Krieger, K., Grunert, F., Micheel, B., Brumer, J., Laffer, U., Metzger, U., Herrmann, R., & Rachlitz, C. (2003). Expression of CEACAM6 in resectable colorectal cancer: A factor of independent prognostic significance. Journal of Clinical Oncology, 21, 3638-3646.
52. Kim, K. S., Kim, J. T., Lee, S. J., Kang, M. A., Choe, I. S., Kang, Y. H., Kim, S. Y., Yeom, Y. I., Lee, Y. H., Kim, J. H., Kim, K. H., Kim, C. N., Kim, J. W., Nam, M. S., & Lee, H. G. (2013). Overexpression and clinical significance of carcinoembryonic antigen-related cell adhesion molecule 6 in colorectal cancer. Clinica Chimica Acta, 415, 12-19.
53. Blumenthal, R. D., Leon, E., Hansen, H.J., & Goldenberg, D.M. (2007). Expression patterns of CEACAM5 and CEACAM6 in primary and metastatic cancers. BioMedCentral Cancer, 7, 2. doi: 10.1186/1471-2407-1187-1182.
54. Frangsmyr, L., Baranov, V., Prall, F., Yeung, M. M., Wagener, C., & Hammarstrom, S. (1995). Cell- and region-specific expression of biliary glycoprotein and its messenger RNA in normal human colonic mucosa. Cancer Research, 55, 2963-2967.
55. Prall, F., Nollau, P., Neumaier, M., Haubeck, H. D., Drzeniek, Z., Helmchen, U., Loning, T., & Wagener, C. (1996). CD66a (BGP), an adhesion molecule of the carcinoembryonic antigen family, is expressed in epithelium, endothelium, and myeloid cells in a wide range of normal human tissues. Journal of Histochemistry and Cytochemistry, 44(1), 35-41.
56. Sundberg, U., & Obrink, B. (2002). CEACAM1 isoforms with different cytoplasmic domains show different localization, organization and adhesive properties in polarized epithelial cells. Journal of Cell Science, 115(Pt 6), 1273-1284.
57. Sundberg, U., Beauchemin, N., & Obrink, B. (2004). The cytoplasmic domain of CEACAM1-L controls its lateral localization and the organization of desmosomes in polarized epithelial cells. Journal of Cell Science, 117(pt 7), 1091-1104.
58. Neumaier, M., Paululat, S., Chan, A., Matthaes, P., & Wagener, C. (1993). Biliary glycoprotein, a potential human cell adhesion molecule, is down-regulated in colorectal carcinomas. Proceedings of the National Academy of Sciences of the United States of America, 90, 10744-10748.
59. Rosenberg, M., Nédellec, P., Jothy, S., Fleiszer, D., Turbide, C., & Beauchemin, N. (1993). The expression of mouse biliary glycoprotein, a carcinoembryonic antigen-related gene, is down-regulated in malignant mouse tissues. Cancer Research, 53, 4938-4945.
60. Busch, C., Hanssen, T. A., Wagener, C., & Obrink, B. (2002). Down-regulation of CEACAM1 in human prostate cancer: Correlation with loss of cell polarity, increased proliferation rate, and Gleason grade 3 to 4 transition. Human Pathology, 33(3), 290-298.
61. Cruz, P. V., Wakai, T., Shirai, Y., Yokoyama, N., & Hatakeyama, K. (2005). Loss of carcinoembryonic antigen-related cell adhesion molecule 1 expression is an adverse prognostic factor in hepatocellular carcinoma. Cancer, 104(2), 354-360.
62. Huang, J., Simpson, J. F., Glackin, C., Riethorf, L., Wagener, C., & Shively, J. E. (1998). Expression of biliary glycoprotein (CD66a) in normal and malignant breast epithelial cells. Anticancer Research, 18(5A), 3203-3212.
63. Nittka, S., Gunther, J., Ebisch, C., Erbersdobler, A., & Neumaier, M. (2004). The human tumor suppressor CEACAM1 modulates apoptosis and is implicated in early colorectal tumorigenesis. Oncogene, 23(58), 9306-9313.
64. Kunath, T., Ordonez-Garcia, C., Turbide, C., & Beauchemin, N. (1995). Inhibition of colonic tumor cell growth by biliary glycoprotein. Oncogene, 11(11), 2375-2382.
65. Hsieh, J.-T., Luo, W., Song, W., Wang, Y., Kleinerman, D. I., Van, N. T., & Lin, S.-H. (1995). Tumor suppressive role of an androgen-regulated epithelial cell adhesion molecule (C-CAM) in prostate carcinoma cell revealed by sense and antisense approaches. Cancer Research, 55, 190-197.
66. Thies, A., Moll, I., Berger, J., Wagener, C., Brummer, J., Schulze, H. J., Brunner, G., & Schumacher, U. (2002). CEACAM1 expression in cutaneous malignant melanoma predicts the development of metastatic disease. Journal of Clinical Oncology, 20(10), 2530-2536.
67. Laack, E., Nikbakht, H., Peters, A., Kugler, C., Jasiewicz, Y., Edler, L., Brummer, J., Schumacher, U., & Hossfeld, D. K. (2002). Expression of CEACAM1 in adenocarcinoma of the lung: A factor of independent prognostic significance. Journal of Clinical Oncology, 20, 4279-4284.
68. Zhou, C. J., Liu, B., Zhu, K. X., Zhang, Q. H., Zhang, T. G., Xu, W. H., Wang, H. B., Yu, W. H., Qu, Y. D., Wang, H. J., Wu, H. L., Sun, S. Z., & Guo, J. Q. (2009). The different expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) and possible roles in gastric carcinomas. Pathology Research and Practice, 205(7), 483-489.
69. Liu, W., Wei, W., Winer, D., Bamberger, A. M., Bamberger, C., Wagener, C., Ezzat, S., & Asa, S. L. (2007). CEACAM1 impedes thyroid cancer growth but promotes invasiveness: A putative mechanism for early metastases. Oncogene, 26, 2747-2758.
70. Oliveira-Ferrer, L., Tilki, D., Ziegeler, G., Hauschild, J., Loges, S., Irmak, S., Kilic, E., Huland, H., Friedrich, M., & Ergun, S. (2004). Dual role of carcinoembryonic antigen-related cell adhesion molecule 1 in angiogenesis and invasion of human urinary bladder cancer. Cancer Research, 64(24), 8932-8938.
71. Fiori, V., Magnani, M., & Cianfriglia, M. (2012). The expression and modulation of CEACAM1 and tumor cell transformation. Annali dell'Intituto Superiore di Sanita, 48(2), 161-171.
72. Ieda, J., Yokoyama, S., Tamura, K., Takifuji, K., Hotta, T., Matsuda, K., Oku, Y., Nasu, T., Kiriyama, S., Yamamoto, N., Makamura, Y., Shively, J. E., & Yamaue, H. (2011). Re-expression of CEACAM1 long cytoplasmic domain isoform is associated with invasion and migration of colorectal cancer. International Journal of Cancer, 129(6), 1351-1361.
73. Tilki, D., Irmak, S., Oliveira-Ferrer, L., Hauschild, J., Miethe, K., Atakaya, H., Hammerer, P., Friedrich, M. G., Schuch, G., Galalae, R., Stief, C. G., Kilic, E., Hurland, H., & Ergun, S. (2006). CEA-related cell adhesion molecule-1 is involved in angiogenic switch in prostate cancer. Oncogene, 25, 4965-4974.
74. Thirunavukarasu, P., Sukumar, S., Sathaiah, M., Mahan, M., Pragatheeshwar, K. D., Pingpank, J. F., Zeh, H., 3rd, Bartels, C. J., Lee, K. K., & Bartlett, D. L. (2011). C-stage in colon cancer: Implications of carcinoembryonic antigen biomarker in staging, prognosis, and management. Journal of the National Cancer Institute, 103(8), 689-697.
75. Clarke, P., Mann, J., Simpson, J. F., Rickard-Dickson, K., & Primus, F. J. (1998). Mice transgenic for human carcinoembryonic antigen as a model for immunotherapy. Cancer Research, 58(7), 1469-1477.
76. Thompson, J. A., Eades-Perner, A. M., Ditter, M., Muller, W. J., & Zimmermann, W. (1997). Expression of transgenic carcinoembryonic antigen (CEA) in tumor-prone mice: An animal model for CEA-directed tumor immunotherapy. International Journal of Cancer, 72(1), 197-202.
77. Johnson, R. L., & Fleet, J. C. (2013). Animal models of colorectal cancer. Cancer and Metastasis Reviews, 32(1-2), 39-61.
78. Chan, C. H., Cook, D., & Stanners, C. P. (2006). Increased colon tumor susceptibility in azoxymethane treated CEABAC transgenic mice. Carcinogenesis, 27(9), 1909-1916.
79. Nambiar, P. R., Girnun, G., Lillo, N. A., Guda, K., Whiteley, H. E., & Rosenberg, D. W. (2003). Preliminary analysis of azoxymethane induced colon tumors in inbred mice commonly used as transgenic/knockout progenitors. International Journal of Oncology, 22, 145-150.
80. Ilantzis, C., Jothy, S., Alpert, L. C., Draber, P., & Stanners, C. P. (1997). Cell-surface levels of human carcinoembryonic antigen are inversely correlated with colonocyte differentiation in colon carcinogenesis. Laboratory Investigation, 76, 703-716.
81. Benchimol, S., Fuks, A., Jothy, S., Beauchemin, N., Shirota, K., & Stanners, C. P. (1989). Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule. Cell, 57(2), 327-334.
82. Jessup, J. M., Kim, J. C., Thomas, P., Ishii, S., Ford, R., Shively, J. E., Durbin, H., Stanners, C. P., Fuks, A., Zhou, H., Hansen, H. J., Goldenberg, D. M., & Steele, G., Jr. (1993). Adhesion to carcinoembryonic antigen by human colorectal carcinoma cells involves at least two epitopes. International Journal of Cancer, 55(2), 262-268.
83. Charbonneau, J., & Stanners, C. P. (1999). Role of carbohydrate structures in CEA-mediated intercellular adhesion. Cell Adhesion and Communication, 7(3), 233-244.
84. Eidelman, F. J., Fuks, A., DeMarte, L., Taheri, M., & Stanners, C. P. (1993). Human carcinoembryonic antigen, an intercellular adhesion molecule, blocks fusion and differentiation of rat myoblasts. The Journal of Cell Biology, 123(2), 467-475.
85. Ilantzis, C., DeMarte, L., Screaton, R. A., & Stanners, C. P. (2002). Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation. Neoplasia, 4(2), 151-163.
86. Ordonez, C., Screaton, R. A., Ilantzis, C., & Stanners, C. P. (2000). Human carcinoembryonic antigen functions as a general inhibitor of anoikis. Cancer Research, 60(13), 3419-3424.
87. Camacho-Leal, P., Zhai, A. B., & Stanners, C. P. (2007). A co-clustering model involving alpha5beta1 integrin for the biological effects of GPI-anchored human carcinoembryonic antigen (CEA). Journal of Cell Physiology, 211(3), 791-802.
88. Saeland, E., Belo, A. I., Mongera, S., van Die, I., Meijer, G. A., & van Kooyk, Y. (2012). Differential glycosylation of MUC1 and CEACAM5 between normal mucosa and tumour tissue of colon cancer patients. International Journal of Cancer, 131(1), 117-128.
89. van Gisbergen, K. P., Aarnoudse, C. A., Meijer, G. A., Geijtenbeek, T. B., & van Kooyk, Y. (2005). Dendritic cells recognize tumor-specific glycosylation of carcinoembryonic antigen on colorectal cancer cells through dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin. Cancer Research, 65(13), 5935-5944.
90. Engering, A., Geijtenbeek, T. B., van Vliet, S. J., Wijers, M., van Liempt, E., Demaurex, N., Lanzavecchia, A., Fransen, J., Figdor, C. G., Piguet, V., & van Kooyk, Y. (2002). The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells. Journal of Immunology, 168(5), 2118-2126.
91. Stern, N., Markel, G., Arnon, T. I., Gruda, R., Wong, H., Gray-Owen, S. D., & Mandelboim, O. (2005). Carcinoembryonic antigen (CEA) inhibits NK killing via interaction with CEA-related cell adhesion molecule 1. Journal of Immunology, 174(11), 6692-6701.
92. Conaghan, P., Ashraf, S., Tytherleigh, M., Wilding, J., Tchilian, E., Bicknell, D., Mortensen, N. J., & Bodmer, W. (2008). Targeted killing of colorectal cancer cell lines by a humanised IgG1 monoclonal antibody that binds to membrane-bound carcinoembryonic antigen. British Journal of Cancer, 98(7), 1217-1225.
93. Zheng, C., Feng, J., Lu, D., Wang, P., Xing, S., Coll, J. L., Yang, D., & Yan, X. (2011). A novel anti-CEACAM5 monoclonal antibody, CC4, suppresses colorectal tumor growth and enhances NK cells-mediated tumor immunity. PLoS One, 6(6), e21146.
94. Berinstein, N. L. (2002). Carcinoembryonic antigen as a target for therapeutic anticancer vaccines: A review. Journal of Clinical Oncology, 20(8), 2197-2207.
95. Hodge, J. W., Poole, D. J., Aarts, W. M., Gómez Yafal, A., Gritz, L., & Schlom, J. (2003). Modified vaccinia virus Ankara recombinants are as potent as vaccinia recombinants in diversified prime and boost vaccine regimens to elicit therapeutic antitumor responses. Cancer Research, 63(22), 7942-7949.
96. Gulley, J. L., Arlen, P. M., Tsang, K. Y., Yokokawa, J., Palena, C., Poole, D. J., Remondo, C., Cereda, V., Jones, J. L., Pazdur, M. P., Higgins, J. P., Hodge, J. W., Steinberg, S. M., Kotz, H., Dahut, W. L., & Schlom, J. (2008). Pilot study of vaccination with recombinant CEA-MUC-1-TRICOM poxviral-based vaccines in patients with metastatic carcinoma. Clinical Cancer Research, 14(10), 3060-3069.
97. Sakakibara, M., Kanto, T., Hayakawa, M., Kuroda, S., Miyatake, H., Itose, I., Miyazaki, M., Kakita, N., Higashitani, K., Matsubara, T., Hiramatsu, N., Kasahara, A., Takehara, T., & Hayashi, N. (2011). Comprehensive immunological analyses of colorectal cancer patients in the phase I/II study of quickly matured dendritic cell vaccine pulsed with carcinoembryonic antigen peptide. Cancer Immunology, Immunotherapy, 60(11), 1565-1575.
98. Hong, X., Dong, T., Hu, J., Yi, T., Li, W., Zhang, Z., Lin, S., & Niu, W. (2013). Synergistical toll-like receptors activated dendritic cells induce antitumor effects against carcinoembryonic antigen-expressing colon cancer. International Journal of Colorectal Disease, 28(1), 25-33.
99. + T cells of lung cancer patients. Journal of Immunology, 176(8), 5093-5099.
100. Abdul-Wahid, A., Huang, E. H., Lu, H., Flanagan, J., Mallick, A. I., & Gariépy, J. (2012). A focused immune response targeting the homotypic binding domain of the carcinoembryonic antigen blocks the establishment of tumor foci in vivo. International Journal of Cancer, 131(12), 2839-2851.
101. Orava, E. W., Abdul-Wahid, A., Huang, E. H., Mallick, A. I., & Gariépy, J. (2013). Blocking the attachment of cancer cells in vivo with DNA aptamers displaying anti-adhesive properties against the carcinoembryonic antigen. Molecular Oncology, S1574-7891(13), 00061-00066. doi: 10.1016/j.molonc.2013.1003.1005.
102. Wilmanns, C., Steinhauer, S., Großmann, J., Schmitt-Gräff, A., & Ruf, G. (2012). Cooperate concept of metastasis: Site-specific requirement of activated differentiation and dynamic deterioration. Cancer and Metastasis Reviews, 31(1-2), 269-276.
103. Spelt, L., Andersson, B., Nilsson, J., & Andersson, R. (2012). Prognostic models for outcome following liver resection for colorectal cancer metastases: A systematic review. European Journal of Surgical Oncology, 38(1), 16-24.
104. Thomas, P., Forse, R. A., & Bajenova, O. (2011). Carcinoembryonic antigen (CEA) and its receptor hnRNP M are mediators of metastasis and the inflammatory response in the liver. Clinical & Experimental Metastasis, 28(8), 923-932.
105. Edmiston, K. H., Gangopadhyay, A., Shoji, Y., Nachman, A. P., Thomas, P., & Jessup, J. M. (1997). In vivo induction of murine cytokine production by carcinoembryonic antigen. Cancer Research, 57(19), 4432-4436.
106. Jessup, J. M., Laguinge, L., Lin, S., Samara, R., Aufman, K., Battle, P., Frantz, M., Edmiston, K. H., & Thomas, P. (2004). Carcinoembryonic antigen induction of IL-10 and IL-6 inhibits hepatic ischemic/reperfusion injury to colorectal carcinoma cells. International Journal of Cancer, 111(3), 332-337.
107. Gangopadhyay, A., Bajenova, O., Kelly, T. M., & Thomas, P. (1996). Carcinoembryonic antigen induces cytokine expression in Kuppfer cells: Implications for hepatic metastasis from colorectal cancer. Cancer Research, 56, 4805-4810.
108. Samara, R. N., Laguinge, L. M., & Jessup, J. M. (2007). Carcinoembryonic antigen inhibits anoikis in colorectal carcinoma cells by interfering with TRAIL-R2 (DR5) signaling. Cancer Research, 67(10), 4774-4782.
109. Li, Y., Cao, H., Jiao, Z., Pakala, S. B., Sirigiri, D. N., Li, W., Kumar, R., & Mishra, L. (2010). Carcinoembryonic antigen interacts with TGF-β receptor and inhibits TGF-β signaling in colorectal cancers. Cancer Research, 70(20), 8159-8168.
110. Massagué, J. (2008). TGFbeta in cancer. Cell, 134(2), 215-230.
111. Blumenthal, R. D., Hansen, H. J., & Goldenberg, D. M. (2005). Inhibition of adhesion, invasion, and metastasis by antibodies targeting CEACAM6 (NCA-90) and CEACAM5 (carcinoembryonic antigen). Cancer Research, 65(19), 8809-8817.
112. Maraqa, L., Cummings, M., Peter, M. B., Shaaban, A. M., Horgan, K., Hanby, A. M., & Speirs, V. (2008). Carcinoembryonic antigen cell adhesion molecule 6 predicts breast cancer recurrence following adjuvant tamoxifen. Clinical Cancer Research, 14(2), 405-411.
113. Lewis-Wambi, J. S., Cunliffe, H. E., Kim, H. R., Willis, A. L., & Jordan, V. C. (2008). Overexpression of CEACAM6 promotes migration and invasion of oestrogen-deprived breast cancer cells. European Journal of Cancer, 44(12), 1770-1779.
114. Witzens-Harig, M., Hose, D., Jünger, S., Pfirschke, C., Khandelwal, N., Umansky, L., Seckinger, A., Conrad, H., Brackertz, B., Rème, T., Gueckel, B., Meißner, T., Hundemer, M., Ho, A.D., Rossi, J.F., Neben, K., Bernhard, H., Goldschmidt, H., Klein, B., & Beckhove, P. (2013). Tumor cells in multiple myeloma patients inhibit myeloma-reactive T cells through carcinoembryonic-antigen-related cell adhesion molecule-6. Blood, 121, 4493-4503.
115. Kobayashi, M., Miki, Y., Ebina, M., Abe, K., Mori, K., Narumi, S., Suzuki, T., Sato, I., Maemondo, M., Endo, C., Inoue, A., Kumamoto, H., Kondo, T., Yamada-Okabe, H., Nukiwa, T., & Sasano, H. (2012). Carcinoembryonic antigen-related cell adhesion molecules as surrogate markers for EGFR inhibitor sensitivity in human lung adenocarcinoma. British Journal of Cancer, 107(10), 1745-1753.
116. Duxbury, M. S., Ito, H., Zinner, M. J., Ashley, S. W., & Whang, E. E. (2004). CEACAM6 gene silencing impairs anoikis resistance and in vivo metastatic ability of pancreatic adenocarcinoma cells. Oncogene, 23(2), 465-473.
117. Duxbury, M. S., Ito, H., Benoit, E., Waseem, T., Ashley, S. W., & Whang, E. E. (2004). A novel role for carcinoembryonic antigen-related cell adhesion molecule 6 as a determinant of gemcitabine chemoresistance in pancreatic adenocarcinoma cells. Cancer Research, 64(11), 3987-3993.
118. Duxbury, M. S., Ito, H., Benoit, E., Ashley, S. W., & Whang, E. E. (2004). CEACAM6 is a determinant of pancreatic adenocarcinoma cellular invasiveness. British Journal of Cancer, 91(7), 1384-1390.
119. Duxbury, M. S., Matros, E., Clancy, T., Bailey, G., Doff, M., Zinner, M. J., Ashley, S. W., Maitra, A., Redston, M., & Whang, E. E. (2005). CEACAM6 is a novel biomarker in pancreatic adenocarcinoma and PanIN lesions. Annals of Surgery, 241(3), 491-496.
120. Duxbury, M. S., Ito, H., Ashley, S. W., & Whang, E. E. (2004). CEACAM6 as a novel target for indirect type 1 immunotoxin-based therapy in pancreatic adenocarcinoma. Biochemical and Biophysical Research Communications, 317(3), 837-843.
121. Strickland, L. A., Ross, J., Williams, S., Ross, S., Romero, M., Spencer, S., Erickson, R., Sutcliffe, J., Verbeke, C., Polakis, P., van Bruggen, N., & Koeppen, H. (2009). Preclinical evaluation of carcinoembryonic cell adhesion molecule (CEACAM) 6 as potential therapy target for pancreatic adenocarcinoma. The Journal of Pathology, 218(3), 380-390.
122. Oikawa, S., Inuzuka, C., Kuroki, M., Arakawa, F., Matsuoka, Y., Kosaki, G., & Nakazato, H. (1991). A specific heterotypic cell adhesion activity between members of carcinoembryonic antigen family, W272 and NCA, is mediated by N-domains. Journal of Biological Chemistry, 266(13), 7995-8001.
123. Kuroki, M., Abe, H., Imakiirei, T., Liao, S., Uchida, H., Yamauchi, Y., et al. (2001). Identification and comparison of residues critical for cell-adhesion activities of two neutrophil CD66 antigens, CEACAM6 and CEACAM8. Journal of Leukocyte Biology, 70(4), 543-550.
124. Obrink, B. (1991). C-CAM (cell-CAM 105) - A member of the growing immunoglobulin superfamily of cell adhesion proteins. Bioessays, 13(5), 227-234.
125. Klaile, E., Vorontsova, O., Sigmundsson, K., Müller, M. M., Singer, B. B., Ofverstedt, L. G., Svensson, S., Skoglund, U., & Obrink, B. (2009). The CEACAM1 N-terminal Ig domain mediates cis- and trans-binding and is essential for allosteric rearrangements of CEACAM1 microclusters. The Journal of Cell Biology, 187(4), 553-567.
126. Watt, S. M., Teixeira, A. M., Zhou, G. Q., Doyonnas, R., Zhang, Y., Grunert, F., et al. (2001). Homophilic adhesion of human CEACAM1 involves N-terminal domain interactions: Structural analysis of the binding site. Blood, 98(5), 1469-1479.
127. Tan, K., Zelus, B. D., Meijers, R., Liu, J. H., Bergelson, J. M., Duke, N., Zhang, R., Joachimiak, A., Holmes, K. V., & Wang, J. H. (2002). Crystal structure of murine sCEACAM1a[1, 4]: A coronavirus receptor in the CEA family. EMBO Journal, 21(9), 2076-2086.
128. Scheffrahn, I., Singer, B. B., Sigmundsson, K., Lucka, L., & Obrink, B. (2005). Control of density-dependent, cell state-specific signal transduction by the cell adhesion molecule CEACAM1, and its influence on cell cycle regulation. Experimental Cell Research, 307(2), 427-435.
129. Lucka, L., Fernando, M., Grunow, D., Kannicht, C., Horst, A. K., Nollau, P., & Wagener, C. (2005). Identification of Lewis X structures of the cell adhesion molecule CEACAM1 from human granulocytes. Glycobiology, 15(1), 87-100.
130. Lawson, E. L., Mills, D. R., Brilliant, K. E., & Hixson, D. C. (2012). The transmembrane domain of CEACAM1-4S is a determinant of anchorage independent growth and tumorigenicity. PLoS One, 7(1), e29606.
131. Margolis, R. N., Taylor, S. I., Seminara, D., & Hubbard, A. L. (1988). Identification of pp 120, an endogenous substrate for the hepatocyte insulin receptor tyrosine kinase, as an integral membrane glycoprotein of the bile canalicular domain. Proceedings of the National Academy of Sciences of the United States of America, 85, 7256-7259.
132. Afar, D. E., Stanners, C. P., & Bell, J. C. (1992). Tyrosine phosphorylation of biliary glycoprotein, a cell adhesion molecule related to carcinoembryonic antigen. Biochimica et Biophysica Acta, 1134(1), 46-52.
133. Brümmer, J., Neumaier, M., Göpfert, C., & Wagener, C. (1995). Association of pp 60c-src with biliary glycoprotein (CD66a), an adhesion molecule of the carcinoembryonic antigen family downregulated in colorectal carcinomas. Oncogene, 11, 1649-1655.
134. Skubitz, K. M., Campbell, K. D., Ahmed, K., & Skubitz, A. P. (1995). CD66 family members are associated with tyrosine kinase activity in human neutrophils. Journal of Immunology, 155(11), 5382-5390.
135. Najjar, S. M., Accili, D., Philippe, N., Jernberg, J., Margolis, R., & Taylor, S. I. (1993). pp 120/ecto-ATPase, an endogenous substrate of the insulin receptor tyrosine kinase, is expressed as two variably spliced isoforms. Journal of Biological Chemistry, 268(2), 1201-1206.
136. Formisano, P., Najjar, S. M., Gross, C. N., Philippe, N., Oriente, F., Kern-Buell, C. L., Accili, D., & Gorden, P. (1995). Receptor-mediated internalization of insulin. Potential role of pp 120/HA4, a substrate of the insulin receptor kinase. Journal of Biological Chemistry, 270(41), 24073-24077.
137. Abou-Rjaily, G. A., Lee, S. J., May, D., Al-Share, Q. Y., Ruch, R. J., Neumaier, M., Kalthoff, H., Lin, S. H., & Najjar, S. M. (2004). CEACAM1 modulates epidermal growth factor receptor-mediated cell proliferation. Journal of Clinical Investigation, 114, 944-952.
138. Beauchemin, N., Kunath, T., Robitaille, J., Chow, B., Turbide, C., Daniels, E., & Veillette, A. (1997). Association of biliary glycoprotein with protein tyrosine phosphatase SHP-1 in malignant colon epithelial cells. Oncogene, 14, 783-790.
139. Huber, M., Izzi, L., Grondin, P., Houde, C., Kunath, T., Veillette, A., & Beauchemin, N. (1999). The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells. Journal of Biological Chemistry, 274(1), 335-344.
140. Müller, M. M., Klaile, E., Vorontsova, O., Singer, B. B., & Obrink, B. (2009). Homophilic adhesion and CEACAM1-S regulate dimerization of CEACAM1-L and recruitment of SHP-2 and c-Src. The Journal of Cell Biology, 187(4), 569-581.
141. Edlund, M., Wikstrom, K., Toomik, R., Ek, P., & Obrink, B. (1998). Characterization of protein kinase C-mediated phosphorylation of the short cytoplasmic domain isoform of C-CAM. FEBS Letters, 425(1), 166-170.
142. Fournes, B., Sadekova, S., Turbide, C., Létourneau, S., & Beauchemin, N. (2001). The CEACAM1-L Ser503 residue is crucial for inhibition of colon cancer cell tumorigenicity. Oncogene, 20(2), 219-230.
143. Poy, M. N., Yang, Y., Rezaei, K., Fernstrom, M. A., Lee, A. D., Kido, Y., Erickson, S. K., & Najjar, S. M. (2002). CEACAM1 regulates insulin clearance in liver. Nature Genetics, 30(3), 270-276.
144. Li, Y., & Shively, J. E. (2013). CEACAM1 regulates Fas-mediated apoptosis in Jurkat T-cells via its interaction with β-catenin. Experimental Cell Research. doi: 10.1016/j.yexcr.2013.1002.1020.
145. Fiset, A., Xu, E., Marette, A., Pelletier, G., Siminovitch, K. A., Olivier, M., Beauchemin, N., & Faure, R. (2007). Compartmentalized CDK2 is connected with SHP-1 and β-catenin and regulates insulin internalization. Cell Signalling, 23(5), 911-919.
146. Li, C., Chen, C. J., & Shively, J. E. (2009). Mutational analysis of the cytoplasmic domain of CEACAM1-4L in humanized mammary glands reveals key residues involved in lumen formation: Stimulation by Thr-457 and inhibition by Ser-461. Experimental Cell Research, 315(7), 1225-1233.
147. Hunter, I., Sawa, H., Edlund, M., & Obrink, B. (1996). Evidence for regulated dimerization of cell-cell adhesion molecule (C-CAM) in epithelial cells. Biochemical Journal, 320(Pt 3), 847-853.
148. Edlund, M., Blikstad, I., & Obrink, B. (1996). Calmodulin binds to specific sequences in the cytoplasmic domain of C-CAM and down-regulates C-CAM self-association. Journal of Biological Chemistry, 271(3), 1393-1399.
149. Jin, L., Li, Y., Chen, C. J., Sherman, M. A., Le, K., & Shively, J. E. (2008). Direct interaction of tumor suppressor CEACAM1 with beta-catenin: Interaction of key residues in the long cytoplasmic domain. Experimental Biology & Medicine (Maywood), 233(7), 849-859.
150. Houde, C., Roy, S., Leung, N., Nicholson, D. W., & Beauchemin, N. (2003). The cell adhesion molecule CEACAM1-L is a substrate of caspase-3-mediated cleavage in apoptotic mouse intestinal cells. Journal of Biological Chemistry, 278(19), 16929-16935.
151. Leung, N., Turbide, C., Balachandra, B., Marcus, V., & Beauchemin, N. (2008). Intestinal tumor progression is promoted by decreased apoptosis and dysregulated Wnt signaling in Ceacam1(-/-) mice. Oncogene, 27(36), 4943-4953.
152. Hanahan, D., & Weinberg, R. A. (2011). Hallmarks of cancer: The next generation. Cell, 144(5), 646-674.
153. Najjar, S. M. (2002). Regulation of insulin action by CEACAM1. Trends in Endocrinology and Metabolism, 13, 240-245.
154. Pollak, M. (2008). Insulin and insulin-like growth factor signalling in neoplasia. Nature Reviews. Cancer, 8(12), 915-928.
155. Poy, M. N., Ruch, R. J., Fernstrom, M. A., Okabayashi, Y., & Najjar, S. M. (2002). Shc and CEACAM1 interact to regulate the mitogenic action of insulin. Journal of Biological Chemistry, 277(2), 1076-1084.
156. Xu, E., Leung, N., Dubois, M. J., Charbonneau, A., Streichert, T., Elcheby, M., Turbide, C., Lévy, E., Beauchemin, N., & Marette, A. (2009). Targeted disruption of Ceacam1 promotes diet-induced hepatic steatosis and insulin resistance. Endocrinology, 150, 3503-3512.
157. Lee, S. J., Heinrich, G., Fedorova, L., Al-Share, Q. Y., Ledford, K. J., Fernstrom, M. A., McInerney, M. F., Erickson, S. K., Gatto-Weis, C., & Najjar, S. M. (2008). Development of nonalcoholic steatohepatitis in insulin-resistant liver-specific S503A carcinoembryonic antigen-related cell adhesion molecule 1 mutant mice. Gastroenterology, 135(6), 2084-2095.
158. Najjar, S. M., Yang, Y., Dai, T., Fernström, M. A., Lee, S. J., DeAngelis, A. M., Abou Rjaily, G. A., Al-Share, Q. Y., Dai, T., Miller, T. A., Ratnam, S., Ruch, R. J., Smith, S., Lin, S. H., Beauchemin, N., & Oyarce, A. M. (2005). Insulin acutely decreases hepatic fatty acid synthase activity. Cell Metabolism, 2(1), 43-53.
159. Flavin, R., Peluso, S., Nguyen, P. L., & Loda, M. (2010). Fatty acid synthase as a potential therapeutic target in cancer. Future Oncology, 6(4), 551-562.
160. Lee, W. (2011). The CEACAM1 expression is decreased in the liver of severely obese patients with or without diabetes. Diagnostic Pathology, 6, 40.
161. Sun, B., & Karin, M. (2012). Obesity, inflammation, and liver cancer. Journal of Hepatology, 56(3), 704-713.
162. Janakiram, N. B., Mohammed, A., & Rao, C. V. (2011). Role of lipoxins, resolvins, and other bioactive lipids in colon and pancreatic cancer. Cancer and Metastasis Reviews, 30(3-4), 507-523.
163. Cathcart, M. C., Lysaght, J., & Pidgeon, G. P. (2011). Eicosanoid signalling pathways in the development and progression of colorectal cancer: Novel approaches for prevention/intervention. Cancer and Metastasis Reviews, 30(3-4), 363-385.
164. Higashiyama, S., Abraham, J. A., Miller, J., Fiddes, J. C., & Klagsbrun, M. (1991). A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science, 251(4996), 936-939.
165. Díaz, B., Yuen, A., Iizuka, S., Higashiyama, S., & Courtneidge, S. A. (2013). Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia. The Journal of Cell Biology, 201(2), 279-292.
166. Kammerer, R., Hahn, S., Singer, B. B., Luo, J. S., & von Kleist, S. (1998). Biliary glycoprotein (CD66a), a cell adhesion molecule of the immunoglobulin superfamily, on human lymphocytes: Structure, expression and involvement in T cell activation. European Journal of Immunology, 28(11), 3664-3674.
167. Singer, B. B., Scheffrahn, I., Heymann, R., Sigmundsson, K., Kammerer, R., & Obrink, B. (2002). Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: Evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes. Journal of Immunology, 168(10), 5139-5146.
168. Morales, V. M., Christ, A., Watt, S. M., Kim, H. S., Johnson, K. W., Utku, N., Texieira, A. M., Mizoguchi, A., Mizoguchi, E., Russell, G. J., Russell, S. E., Bhan, A. K., Freeman, G. J., & Blumberg, R. S. (1999). Regulation of human intestinal intraepithelial lymphocyte cytolytic function by biliary glycoprotein (CD66a). Journal of Immunology, 163(3), 1363-1370.
169. Nakajima, A., Iijima, H., Neurath, M. F., Nagaishi, T., Nieuwenhuis, E. E., Raychowdhury, R., Glickman, J., Blau, D. M., Russell, S., Holmes, K. V., & Blumberg, R. S. (2002). Activation-induced expression of carcinoembryonic antigen-cell adhesion molecule 1 regulates mouse T lymphocyte function. Journal of Immunology, 168(3), 1028-1035.
170. Nagaishi, T., Iijima, H., Nakajima, A., Chen, D., & Blumberg, R. S. (2006). Role of CEACAM1 as a regulator of T cells. Annals of the New York Academy of Sciences, 1072, 155-175.
171. Chen, C. J., & Shively, J. E. (2004). The cell-cell adhesion molecule CEACAM1 inhibits IL-2 production and proliferation in human T-cell by association with activated Src homology protein-1 and down-regulates IL-2 receptor. Journal of Immunology, 172, 3544-3552.
172. Chen, D., Iijima, H., Nagaishi, T., Nakajima, A., Russell, S., Raychowdhury, R., Morales, V., Rudd, C. W., Utku, N., & Blumberg, R. S. (2004). Carcinoembryonic antigen-related cellular adhesion molecule 1 isoforms alternatively inhibit and costimulate human T cell function. Journal of Immunology, 172, 3535-3543.
173. Chen, Z., Chen, L., Qiao, S. W., Nagaishi, T., & Blumberg, R. S. (2008). Carcinoembryonic antigen-related cell adhesion molecule 1 inhibits proximal TCR signaling by targeting ZAP-70. Journal of Immunology, 180, 6085-6093.
174. Nagaishi, T., Pao, L., Lin, S. H., Iijima, H., Kaser, A., Qiao, S. W., Chen, Z., Glickman, J., Najjar, S. M., Nakajima, A., Neel, B. G., & Blumberg, R. S. (2006). SHP1 phosphatase-dependent T cell inhibition by CEACAM1 adhesion molecule isoforms. Immunity, 25, 769-781.
175. Chen, L., Chen, Z., Baker, K., Halvorsen, E. M., da Cunha, A. P., Flak, M. B., Gerber, G., Huang, Y. H., Hosomi, S., Arthur, J. C., Dery, K. J., Nagaishi, T., Beauchemin, N., Holmes, K. V., Ho, J. W., Shively, J. E., Jobin, C., Onderdonk, A. B., Bry, L., Weiner, H. L., Higgins, D. E., & Blumberg, R. S. (2012). The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction. Immunity, 37(5), 930-946.
176. Arthur, J. C., & Jobin, C. (2013). The complex interplay between inflammation, the microbiota and colorectal cancer. Gut Microbes, 4(3), 253-258.
177. Moller, M. J., Kammerer, R., Grunert, F., & von Kleist, S. (1996). Biliary glycoprotein (BGP) expression on T cells and on a natural-killer-cell sub-population. International Journal of Cancer, 65(6), 740-745.
178. Markel, G., Wolf, D., Hanna, J., Gazit, R., Goldman-Wohl, D., Lavy, Y., Yagel, S., & Mandelboim, O. (2002). Pivotal role of CEACAM1 protein in the inhibition of activated decidual lymphocyte functions. Journal of Clinical Investigation, 110, 943-953.
179. Kammerer, R., Riesenberg, R., Weiler, C., Lohtmann, J., Schleypen, J., & Zimmermann, W. (2004). The tumour suppressor gene CEACAM1 is completely but reversibly downregulated in renal cell carcinoma. The Journal of Pathology, 204, 258-267.
180. Hosomi, S., Chen, Z., Baker, K., Chen, L., Huang, Y.H., Olszak, T., Zeissig, S., Wang, J.H., Mandelboim, O., Beauchemin, N., Lanier, L.L., & Blumberg, R.S. (2013). CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling. European Journal of Immunology. doi: 10.1002/eji.201242676.
181. Chen, Z., Chen, L., Baker, K., Olszak, T., Zeissig, S., Huang, Y. H., Mandelboim, O., Beauchemin, N., Lanier, L. L., & Blumberg, R. S. (2011). CEACAM1 dampens anti-tumor immunity by downregulation of NKG2D ligand expression on tumor cells and NKG2D function on NK cells. The Journal of Experimental Medicine, 208(13), 2633-2640.
182. Chen, T., Zimmermann, W., Parker, J., Chen, I., Maeda, A., & Bolland, S. (2001). Biliary glycoprotein (BGPa, CD66a, CEACAM1) mediates inhibitory signals. Journal of Leukocyte Biology, 70(2), 335-340.
183. Greicius, G., Severinson, E., Beauchemin, N., Obrink, B., & Singer, B. (2003). CEACAM1 is a potent regulator of B cell receptor complex-induced activation. Journal of Leukocyte Biology, 74, 126-134.
184. Lobo, E. O., Zhang, Z., & Shively, J. E. (2009). Pivotal advance: CEACAM1 is a negative coreceptor for the B cell receptor and promotes CD19-mediated adhesion of B cells in a PI3K-dependent manner. Journal of Leukocyte Biology, 86(2), 205-218.
185. Satoh, Y., Hayashi, T., Takahashi, T., Itoh, F., Adachi, M., Fukui, M., Kuroki, M., Kuroki, M., Imai, K., & Hinoda, Y. (2002). Expression of CD66a in multiple myeloma. Journal of Clinical Laboratory Analysis, 16(2), 79-85.
186. Skubitz, K. M., Ducker, T. P., & Goueli, S. A. (1992). CD66 monoclonal antibodies recognize a phosphotyrosine-containing protein bearing a carcinoembryonic antigen cross-reacting antigen on the surface of human neutrophils. Journal of Immunology, 148(3), 852-860.
187. Botling, J., Oberg, F., & Nilsson, K. (1995). CD49f (alpha 6 integrin) and CD66a (BGP) are specifically induced by retinoids during human monocytic differentiation. Leukemia, 9(12), 2034-2041.
188. Pan, H., & Shively, J. E. (2010). Carcinoembryonic antigen-related cell adhesion molecule-1 regulates granulopoiesis by inhibition of granulocyte colony-stimulating factor receptor. Immunity, 33(4), 620-631.
189. Singer, B. B., Klaile, E., Scheffrahn, I., Müller, M. M., Kammerer, R., Reutter, W., Obrink, B., & Lucka, L. (2005). CEACAM1 (CD66a) mediates delay of spontaneous and Fas ligand-induced apoptosis in granulocytes. European Journal of Immunology, 35(6), 1949-1959.
190. Yu, Q., Chow, E. M., Wong, H., Gu, J., Mandelboim, O., Gray-Owen, S. D., & Ostrowski, M. A. (2006). CEACAM1 (CD66a) promotes human monocyte survival via a phosphatidylinositol 3-kinase- and AKT-dependent pathway. Journal of Biological Chemistry, 281(51), 39179-39193.
191. Kammerer, R., Stober, D., Singer, B. B., Obrink, B., & Reimann, J. (2001). Carcinoembryonic antigen-related cell adhesion molecule 1 on murine dendritic cells is a potent regulator of T cell stimulation. Journal of Immunology, 166(11), 6537-6544.
192. van Gisbergen, K. P., Ludwig, I. S., Geijtenbeek, T. B., & van Kooyk, Y. (2005). Interactions of DC-SIGN with Mac-1 and CEACAM1 regulate contact between dendritic cells and neutrophils. FEBS Letters, 579(27), 6159-6168.
193. Bogoevska, V., Horst, A., Klampe, B., Lucka, L., Wagener, C., & Nollau, P. (2006). CEACAM1, an adhesion molecule of human granulocytes, is fucosylated by fucosyltransferase IX and interacts with DC-SIGN of dendritic cells via Lewis X residues. Glycobiology, 16(3), 197-209.
194. Nonaka, M., Ma, B. Y., Murai, R., Nakamura, N., Baba, M., Kawasaki, N., Hodohara, K., Asano, S., & Kawasaki, T. (2008). Glycosylation-dependent interactions of C-type lectin DC-SIGN with colorectal tumor-associated Lewis glycans impair the function and differentiation of monocyte-derived dendritic cells. Journal of Immunology, 180(5), 3347-3356.
195. Schumann, D., Chen, C. J., Kaplan, B., & Shively, J. E. (2001). Carcinoembryonic antigen cell adhesion molecule 1 directly associates with cytoskeleton proteins actin and tropomyosin. Journal of Biological Chemistry, 276(50), 47421-47433.
196. Sadekova, S., Lamarche-Vane, N., Li, X., & Beauchemin, N. (2000). The CEACAM1-L glycoprotein associates with the actin cytoskeleton and localizes to cell-cell contact through activation of Rho-like GTPases. Molecular Biology of the Cell, 11(1), 65-77.
197. Chen, C. J., Kirshner, J., Sherman, M. A., Hu, W., Nguyen, T., & Shively, J. E. (2007). Mutation analysis of the short cytoplasmic domain of the cell-cell adhesion molecule CEACAM1 identifies residues that orchestrate actin binding and lumen formation. Journal of Biological Chemistry, 282(8), 5749-5760.
198. Ebrahimnejad, A., Flayeh, R., Unteregger, G., Wagener, C., & Brummer, J. (2000). Cell adhesion molecule CEACAM1 associates with paxillin in granulocytes and epithelial and endothelial cells. Experimental Cell Research, 260(2), 365-373.
199. Klaile, E., Muller, M. M., Kannicht, C., Singer, B. B., & Lucka, L. (2005). CEACAM1 functionally interacts with filamin A and exerts a dual role in the regulation of cell migration. Journal of Cell Science, 118, 5513-5524.
200. Muller, M. M., Singer, B. B., Klaile, E., Obrink, B., & Lucka, L. (2005). Transmembrane CEACAM1 affects integrin-dependent signaling and regulates extracellular matrix protein-specific morphology and migration of endothelial cells. Blood, 105(10), 3925-3934.
201. Brummer, J., Ebrahimnejad, A., Flayeh, R., Schumacher, U., Loning, T., Bamberger, A. M., & Wagener, C. (2001). cis Interaction of the cell adhesion molecule CEACAM1 with integrin beta(3). American Journal of Pathology, 159(2), 537-546.
202. Ebrahimnejad, A., Streichert, T., Nollau, P., Horst, A. K., Wagener, C., Bamberger, A. M., & Brummer, J. (2004). CEACAM1 enhances invasion and migration of melanocytic and melanoma cells. American Journal of Pathology, 165, 1781-1787.
203. Briese, J., Schulte, H. M., Bamberger, C. M., Löning, T., & Bamberger, A. M. (2006). Expression pattern of osteopontin in endometrial carcinoma: Correlation with expression of the adhesion molecule CEACAM1. International Journal of Gynecology and Pathology, 25(2), 161-169.
204. Kluger, H. M., Hoyt, K., Bacchiocchi, A., Mayer, T., Kirsch, J., Kluger, Y., Sznol, M., Ariyan, S., Molinaro, A., & Halaban, R. (2011). Plasma markers for identifying patients with metastatic melanoma. Clinical Cancer Research, 17(8), 2417-2425.
205. Ergün, S., Kilic, N., Ziegeler, G., Hansen, A., Nollau, P., Götze, J., Wurmbach, J. H., Horst, A., Weil, J., Fernando, M., & Wagener, C. (2000). CEA-related cell adhesion molecule 1 (CEACAM1): A potent angiogenic factor and a major effector of vascular endothelial growth factor (VEGF). Molecular Cell, 5, 311-320.
206. Horst, A. K., Wulf, D. I., Dabelstein, J., Schumacher, U., Sander, H., Turbide, C., Brummer, J., Meinertz, T., Beauchemin, N., & Wagener, C. (2006). Carcinoembryonic antigen-related cell adhesion molecule 1 modulates vascular remodeling in vitro and in vivo. Journal of Clinical Investigation, 116(6), 1596-1605.
207. Nouvion, A. L., Oubaha, M., LeBlanc, S., Davis, E. C., Jastrow, H., Kammerer, R., Breton, V., Turbide, C., Ergun, S., Gratton, J. P., & Beauchemin, N. (2010). CEACAM1: A key regulator of vascular permeability. Journal of Cell Science, 123(24), 4221-4230.
208. Gerstel, D., Wegwitz, F., Jannasch, K., Ludewig, P., Scheike, K., Alves, F., Beauchemin, N., Deppert, W., Wagener, C., & Horst, A. K. (2011). CEACAM1 creates a pro-angiogenic tumor microenvironment that supports tumor vessel maturation. Oncogene, 30(41), 4275-4288.
209. + myeloid cells control angiogenesis in inflammation. Blood, 113(26), 6726-6736.
210. Lu, R., Kujawski, M., Pan, H., & Shively, J. E. (2012). Tumor angiogenesis mediated by myeloid cells is negatively regulated by CEACAM1. Cancer Research, 72(9), 2239-2250.
211. Samineni, S., Zhang, Z., & Shively, J. E. (2013). Carcinoembryonic antigen-related cell adhesion molecule 1 negatively regulates granulocyte colony-stimulating factor production by breast tumor-associated macrophages that mediate tumor angiogenesis. International Journal of Cancer 133(2), 394-407.
212. Arabzadeh, A., Chan, C., Nouvion, A. L., Breton, V., Benlolo, S., DeMarte, L., Turbide, C., Brodt, P., Ferri, L., & Beauchemin, N. (2012). Host-related carcinoembryonic antigen cell adhesion molecule 1 promotes metastasis of colorectal cancer. Oncogene, 32(7), 849-860.
213. Sappino, A. P., Buser, R., Seguin, Q., Fernet, M., Lesne, L., Gumy-Pause, F., Reith, W., Favaudon, V., & Mandriota, S. J. (2012). The CEACAM1 tumor suppressor is an ATM and p53-regulated gene required for the induction of cellular senescence by DNA damage. Oncogenesis, 1, e7.
214. Klaile, E., Kukalev, A., Obrink, B., & Müller, M. M. (2008). PDIP38 is a novel mitotic spindle-associated protein that affects spindle organization and chromosome segregation. Cell Cycle, 7(20), 3180-3186.
215. Klaile, E., Müller, M. M., Kannicht, C., Otto, W., Singer, B. B., Reutter, W., Obrink, B., & Lucka, L. (2007). The cell adhesion receptor carcinoembryonic antigen-related cell adhesion molecule 1 regulates nucleocytoplasmic trafficking of DNA polymerase delta-interacting protein 38. Journal of Biological Chemistry, 282(36), 26629-26640.
216. Terahara, K., Yoshida, M., Taguchi, F., Igarashi, O., Nochi, T., Gotoh, Y., Yamamoto, T., Tsunetsugu-Yokota, Y., Beauchemin, N., & Kiyono, H. (2009). Expression of newly identified secretory CEACAM1(a) isoforms in the intestinal epithelium. Biochemical and Biophysical Research Communications, 383(3), 340-346.
217. Kirshner, J., Hardy, J., Wilczynski, S., & Shively, J. E. (2004). Cell-cell adhesion molecule CEACAM1 is expressed in normal breast and milk and associates with beta1 integrin in a 3D model of morphogenesis. Journal of Molecular Histology, 35(3), 287-299.
218. Zhang, H., Eisenried, A., Zimmermann, W., & Shively, J. E. (2013). Role of CEACAM1 and CEACAM20 in an in vitro model of prostate morphogenesis. PLoS One, 8(1), e53359.
219. Huang, J., Hardy, J. D., Sun, Y., & Shively, J. E. (1999). Essential role of biliary glycoprotein (CD66a) in morphogenesis of the human mammary epithelial cell line MCF10F. Journal of Cell Science, 112(23), 4193-4205.
220. Alegre, M. L., Shiels, H., Thompson, C. B., & Gajewski, T. F. (1998). Expression and function of CTLA-4 in Th1 and Th2 cells. Journal of Immunology, 161(7), 3347-3356.
221. Riley, J. L. (2009). PD-1 signaling in primary T cells. Immunological Reviews, 229(1), 114-125.
222. Sapoznik, S., Hammer, O., Ortenberg, R., Besser, M. J., Ben-Moshe, T., Schachter, J., & Markel, G. (2012). Novel anti-melanoma immunotherapies: Disarming tumor escape mechanisms. Clinical and Developmental Immunology, 2012, 818214.
223. Curran, M. A., Montalvo, W., Yagita, H., & Allison, J. P. (2010). PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors. Proceedings of the National Academy of Sciences of the United States of America, 107(9), 4275-4280.
224. (2013). Inhibiting CTLA-4 and PD-1 Boosts Response. Cancer Discovery. doi: 10.1158/2159-8290.CD-NB2013-076.
225. Ortenberg, R., Sapir, Y., Raz, L., Hershkovitz, L., Ben Arav, A., Sapoznik, S., Barshack, I., Avivi, C., Berkun, Y., Besser, M. J., Ben-Moshe, T., Schachter, J., & Markel, G. (2012). Novel immunotherapy for malignant melanoma with a monoclonal antibody that blocks CEACAM1 homophilic interactions. Molecular Cancer Therapy, 11(6), 1300-1310.
226. Liu, J., Di, G., Wu, C. T., Hu, X., & Duan, H. (2013). Development and evaluation of a novel anti-colorectal cancer monoclonal antibody, WL5. Biochemical and Biophysical Research Communications, 432(2), 370-377.
227. Humphries, M. J. (1999). Towards a structural model of an integrin. Biochemical Society Symposia, 65, 63-78.
228. Singer, B. B., Scheffrahn, I., Kammerer, R., Suttorp, N., Ergun, S., & Slevogt, H. (2010). Deregulation of the CEACAM expression pattern causes undifferentiated cell growth in human lung adenocarcinoma cells. PLoS One, 5(1), e8747.
229. Jantscheff, P., Nagel, G., Thompson, J., von Kleist, S., Embleton, M. J., Price, M. R., & Grunert, F. (1996). A CD66a-specific, activation-dependent epitope detected by recombinant human single chain fragments (scFvs) on CHO transfectants and activated granulocytes. Journal of Leukocyte Biology, 59(6), 891-901.
230. Chan, C. H., & Stanners, C. P. (2004). Novel mouse model for carcinoembryonic antigen-based therapy. Molecular Therapy, 9, 775-785.
231. Leung, N., Turbide, C., Marcus, V., Jothy, S., & Beauchemin, N. (2006). Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) contributes to progression of colon tumors. Oncogene, 25, 5527-5536.
232. Gu, A., Zhang, Z., Zhang, N., Tsark, W., & Shively, J. E. (2010). Generation of human CEACAM1 transgenic mice and binding of Neisseria Opa protein to their neutrophils. PLoS One, 5(4), e10067.
233. Hauck, W., Nédellec, P., Turbide, C., Stanners, C. P., Barnett, T. R., & Beauchemin, N. (1994). Transcriptional control of the human biliary glycoprotein gene, a CEA gene family member down-regulated in colorectal carcinomas. European Journal of Biochemistry, 223, 529-541.
234. Shimada, R., Iinuma, H., Akahane, T., Horiuchi, A., & Watanabe, T. (2012). Prognostic significance of CTCs and CSCs of tumor drainage vein blood in Dukes' stage B and C colorectal cancer patients. Oncology Reports, 27(4), 947-953.
235. Gemei, M., Mirabelli, P., Di Noto, R., Corbo, C., Iaccarino, A., Zamboli, A., Troncone, G., Galizia, G., Lieto, E., Del Vecchio, L., & Salvatore, F. (2013). CD66c is a novel marker for colorectal cancer stem cell isolation, and its silencing halts tumor growth in vivo. Cancer, 119(4), 729-738.
236. Zengin, E., Chalajour, F., Gehling, U. M., Ito, W. D., Treede, H., Lauke, H., Weil, J., Reichenspurner, H., Kilic, N., & Ergun, S. (2006). Vascular wall resident progenitor cells: A source for postnatal vasculogenesis. Development, 133(8), 1543-1551.
237. Profumo, V., & Gandellini, P. (2013). MicroRNAs: Cobblestones on the road to cancer metastasis. Critical Reviews in Oncogenesis, 18(4), 341-355.
238. Tran, R., Kashmiri, S. V., Kantor, J., Greiner, J. W., Pestka, S., Shively, J. E., & Schlom, J. (1988). Correlation of DNA hypomethylation with expression of carcinoembryonic antigen in human colon carcinoma cells. Cancer Research, 48(20), 5674-5679.
239. Kim, M. S., Lee, J., & Sidransky, D. (2010). DNA methylation markers in colorectal cancer. Cancer and Metastasis Reviews, 29(1), 181-206.