The different expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) and possible roles in gastric carcinomas

Pathology Research and Practice

Volumn 205, Issue 7, 2009, Pages 483-489

  Zhou, Cheng Jun ^a,b   Liu, Bin ^a   Zhu, Kong Xi ^a   Zhang, Qing Hui ^b   Zhang, Ting Guo ^b   Xu, Wei Hua ^a   Wang, Hong Bo ^a   Yu, Wei Hua ^a   Qu, Yun Dong ^a   Wang, Hong Juan ^a   Wu, Hong Li ^a   Sun, Shan Zhen ^a   Guo, Jian Qiang ^a  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Angiogenesis; CEACAM1; Gastric adenocarcinoma; Laur n classification; Lymph node metastasis

Indexed keywords

CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 1;

ADULT; ARTICLE; CANCER CLASSIFICATION; CELL MEMBRANE; CYTOPLASM; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTESTINE CARCINOMA; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MIXED TUMOR; PROTEIN ANALYSIS; PROTEIN EXPRESSION; STOMACH ADENOCARCINOMA; STOMACH CARCINOGENESIS; STOMACH CARCINOMA; STOMACH SURGERY; TISSUE DISTRIBUTION; TUMOR VASCULARIZATION;

ADENOCARCINOMA; ANTIGENS, CD; ANTIGENS, CD31; CELL ADHESION; CELL ADHESION MOLECULES; CELL MEMBRANE; CYTOSOL; FEMALE; GASTRIC MUCOSA; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; MALE; METAPLASIA; MICROVESSELS; MIDDLE AGED; NEOVASCULARIZATION, PATHOLOGIC; PROTEIN TRANSPORT; STOMACH NEOPLASMS;

EID: 67349115189     PISSN: 03440338     EISSN: 16180631     Source Type: Journal    
DOI: 10.1016/j.prp.2009.01.006     Document Type: Article

References (20)

1. Singer B.B., Scheffrahn I., and Obrink B. The tumor growth-inhibiting cell adhesion molecule CEACAM1 (C-CAM) is differently expressed in proliferating and quiescent epithelial cells and regulates cell proliferation. Cancer Res. 60 (2000) 1236-1244
2. Nakajima A., Iijima H., Neurath M.F., Nagaishi T., Nieuwenhuis E.E., Raychowdhury R., Glickman J., et al. Activation-induced expression of carcinoembryonic antigen-cell adhesion molecule 1 regulates mouse T lymphocyte function. J. Immunol. 168 (2002) 1028-1035
3. Chen D., Iijima H., Nagaishi T., Nakajima A., Russell S., Raychowdhury R., Morales V., et al. Carcinoembryonic antigen-related cellular adhesion molecule 1 isoforms alternatively inhibit and costimulate human T cell function. J. Immunol. 172 (2004) 3535-3543
4. Ergun S., Kilic N., Ziegeler G., Hansen A., Nollau P., Gotze J., et al. CEA-related cell adhesion molecule 1: a potent angiogenic factor and a major effector of vascular endothelial growth factor. Mol. Cell 5 (2000) 311-320
5. Wagener C., and Ergun S. Angiogenic properties of the carcinoembryonic antigen-related cell adhesion molecule 1. Exp. Cell Res. 261 (2000) 19-24
6. Kilic N., Oliveira-Ferrer L., Wurmbach J.-H., Loges S., et al. Pro-angiogenic signaling by the endothelial presence of CEACAM1. J. Biol. Chem. 280 3 (2005) 2361-2369
7. Chalajour F., Treede H., Ebrahimnejad A., et al. Angiogenic activation of valvular endothelial cells in aortic valve stenosis. Exp. Cell Res. 298 (2004) 455-464
8. Oliveira-Ferrer L., Tilki D., Ziegeler G., Hauschild J., Loges S., et al. Dual role of carcinoembryonic antigen-related cell adhesion molecule 1 in angiogenesis and invasion of human urinary bladder cancer. Cancer Res. 64 (2004) 8932-8938
9. Phan D., Cheng C.J., Galfione M., Vakar-Lopez F., Tunstead J., Thompson N.E., Burgess R.R., et al. Identification of Sp2 as a transcriptional repressor of carcinoembryonic antigen-related cell adhesion molecule 1 in tumorigenesis. Cancer Res. 64 (2004) 3072-3078
10. Kammerer R., Riesenberg R., Weiler C., Lohrmann J., Achleypen J., and Zimmermann W. The tumour suppressor gene CEACAM1is completely but reversibly downregulated in renal cell carcinoma. J. Pathol. 204 (2004) 258-267
11. Laack E., Nikbakht H., Petera A., Kugler C., Jasiewicz Y., et al. Expression of CEACAM1 in adenocarcinoma of the lung: a factor of independent prognostic significance. J. Clin. Oncol. 20 (2002) 4279-4284
12. Kang W.-Y., Chen W.-T., and Wu M.-T. The expression of CD66a and possible roles in colorectal adenoma and adenocarcinoma. Int. J. Colorectal Dis. 22 (2007) 869-874
13. Ana-Maria Bamberger M.D., udahl S.S., Christoph Wagener M.D., and Thomas Loning M.D. Expression pattern of the adhesion molecule CEACAM1(C-CAM, CD66a, BGP) in gestational trophpblastic lesions. Int. J. Gynecol. Pathol. 20 (2001) 160-165
14. Hamilton S.R., and Aaltonen L.A. WHO Classification of Tumours: Pathology and Genetics of Tumours of the Digestive System (2000), IARC Press, Lyon
15. Dango S., Sienel W., Schreiber M., Stremmel C., Kirschbaum A., Pantel K., and Passlick B. Elevated expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM-1) is associated with increased angiogenic potential in non-small-cell lung cancer. Lung Cancer 60 (2008) 426-433
16. Muller M.M., Singer B.B., Klaile E., et al. Transmembrane CEACAM1 affects integrin-dependent signaling and regulates extracellular matrix protein-specific morphology and migration of endothelial cells. Blood 105 (2005) 3925-3934
17. Tilki D., Irmak S., Oliveira-Ferrer L., et al. CEA-related cell adhesion molecule-1 is involved in angiogenic switch in prostate cancer. Oncogene 25 (2006) 4965-4974
18. Gray-Owen S.D., and Blumberg R.S. CEACAM1: contact-dependent control of immunity. Immunology 6 (2006) 433-446
19. Riethdorf L., Lisboa B., Henkel U., Naumann M., Wagener C., and Löning T. Differential expression of CD66a (BGP), a cell adhesion molecule of the carcinoembryonic antigen family, in benign, premalignant, and malignant lesions of the human mammary gland. J. Histochem. Cytochem. 45 (1997) 957-964
20. Volpert O., Luo W., Liu T.-J., Vicky T., et al. Inhibition of prostate tumor angiogenesis by the tumor suppressor CEACAM1. J. Biol. Chem. 277 38 (2002) 35696-35702