Role of CEACAM1 and CEACAM20 in an In Vitro Model of Prostate Morphogenesis

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Zhang, Hui ^a   Eisenried, Andreas ^b   Zimmermann, Wolfgang ^c   Shively, John E ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^c Labor fürTumorimmunologie LIFE Zentrum   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACID PHOSPHATASE PROSTATE ISOENZYME; ANDROGEN RECEPTOR ANTAGONIST; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 1; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 20; CYTOKERATIN 14; CYTOKERATIN 18; CYTOKERATIN 5; CYTOKERATIN 8; MEMBRANE PROTEIN; MESSENGER RNA; PROSTATE SPECIFIC ANTIGEN; UNCLASSIFIED DRUG;

ARTICLE; CARCINOGENESIS; CELL DIFFERENTIATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DOWN REGULATION; EXTRACELLULAR MATRIX; GENE EXPRESSION; GONAD DEVELOPMENT; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR SIGNALING; MALE; MOLECULAR PATHOLOGY; PROSTATE CANCER; PROSTATE MORPHOGENESIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION;

ANTIGENS, CD; BLOTTING, WESTERN; CELL ADHESION MOLECULES; CELL DIFFERENTIATION; CELLS, CULTURED; COLLAGEN; DRUG COMBINATIONS; EPITHELIAL CELLS; HUMANS; LAMININ; MALE; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; MODELS, BIOLOGICAL; MORPHOGENESIS; POLYMERASE CHAIN REACTION; PROSTATE; PROTEOGLYCANS;

EID: 84872876598     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0053359     Document Type: Article

References (41)

1. Wagener C, Ergun S, (2000) Angiogenic properties of the carcinoembryonic antigen-related cell adhesion molecule 1. Exp Cell Res 261: 19-24.
2. Najjar SM, (2002) Regulation of insulin action by CEACAM1. Trends Endocrinol Metab 13: 240-245.
3. Abou-Rjaily GA, Lee SJ, May D, Al-Share QY, Deangelis AM, et al. (2004) CEACAM1 modulates epidermal growth factor receptor-mediated cell proliferation. J Clin Invest 114: 944-952.
4. Kirshner J, Chen CJ, Liu P, Huang J, Shively JE, (2003) CEACAM1-4S, a cell-cell adhesion molecule, mediates apoptosis and reverts mammary carcinoma cells to a normal morphogenic phenotype in a 3D culture. Proc Natl Acad Sci U S A 100: 521-526.
5. Zebhauser R, Kammerer R, Eisenried A, McLellan A, Moore T, et al. (2005) Identification of a novel group of evolutionarily conserved members within the rapidly diverging murine Cea family. Genomics 86: 566-580.
6. Busch C, Hanssen TA, Wagener C, O'Brink B, (2002) Down-regulation of CEACAM1 in human prostate cancer: correlation with loss of cell polarity, increased proliferation rate, and Gleason grade 3 to 4 transition. Hum Pathol 33: 290-298.
7. Comegys MM, Carreiro MP, Brown JF, Mazzacua A, Flanagan DL, et al. (1999) C-CAM1 expression: differential effects on morphology, differentiation state and suppression of human PC-3 prostate carcinoma cells. Oncogene 18: 3261-3276.
8. Tilki D, Irmak S, Oliveira-Ferrer L, Hauschild J, Miethe K, et al. (2006) CEA-related cell adhesion molecule-1 is involved in angiogenic switch in prostate cancer. Oncogene 25: 4965-4974.
9. Stein CA, Hansen JB, Lai J, Wu S, Voskresenskiy A, et al. (2010) Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents. Nucleic Acids Res 38: e3.
10. You YH, Hefta LJ, Yazaki PJ, Wu AM, Shively JE, (1998) Expression, purification, and characterization of a two domain carcinoembryonic antigen minigene (N-A3) in pichia pastoris. The essential role of the N-domain. Anticancer Res 18: 3193-3201.
11. Schumann D, Huang J, Clarke PE, Kirshner J, Tsai SW, et al. (2004) Characterization of recombinant soluble carcinoembryonic antigen cell adhesion molecule 1. Biochem Biophys Res Commun 318: 227-233.
12. Zhang Z, Shively JE, (2010) Generation of novel bone forming cells (monoosteophils) from the cathelicidin-derived peptide LL-37 treated monocytes. PLoS One 5: e13985.
13. Chen CJ, Nguyen T, Shively JE, (2010) Role of calpain-9 and PKC-delta in the apoptotic mechanism of lumen formation in CEACAM1 transfected breast epithelial cells. Exp Cell Res 316: 638-648.
14. Chen CJ, Kirshner J, Sherman MA, Hu W, Nguyen T, et al. (2007) Mutation analysis of the short cytoplasmic domain of the cell-cell adhesion molecule CEACAM1 identifies residues that orchestrate actin binding and lumen formation. J Biol Chem 282: 5749-5760.
15. Gencheva M, Chen CJ, Nguyen T, Shively JE, (2010) Regulation of CEACAM1 transcription in human breast epithelial cells. BMC Mol Biol 11: 79.
16. Huang J, Hardy JD, Sun Y, Shively JE, (1999) Essential role of biliary glycoprotein (CD66a) in morphogenesis of the human mammary epithelial cell line MCF10F. J Cell Sci 112 (Pt 23):: 4193-4205.
17. Berthois Y, Katzenellenbogen JA, Katzenellenbogen BS, (1986) Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture. Proc Natl Acad Sci U S A 83: 2496-2500.
18. Goldstein AS, Drake JM, Burnes DL, Finley DS, Zhang H, et al. (2011) Purification and direct transformation of epithelial progenitor cells from primary human prostate. Nat Protoc 6: 656-667.
19. Kirshner J, Hardy J, Wilczynski S, Shively JE, (2004) Cell-cell adhesion molecule CEACAM1 is expressed in normal breast and milk and associates with beta1 integrin in a 3D model of morphogenesis. J Mol Histol 35: 287-299.
20. Prakash TP, Bhat B, (2007) 2′-Modified oligonucleotides for antisense therapeutics. Curr Top Med Chem 7: 641-649.
21. Yokoyama S, Chen CJ, Nguyen T, Shively JE, (2007) Role of CEACAM1 isoforms in an in vivo model of mammary morphogenesis: mutational analysis of the cytoplasmic domain of CEACAM1-4S reveals key residues involved in lumen formation. Oncogene 26: 7637-7646.
22. Collins AT, Berry PA, Hyde C, Stower MJ, Maitland NJ, (2005) Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res 65: 10946-10951.
23. Gudjonsson T, Villadsen R, Nielsen HL, Ronnov-Jessen L, Bissell MJ, et al. (2002) Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties. Genes Dev 16: 693-706.
24. Benton G, George J, Kleinman HK, Arnaoutova IP, (2009) Advancing science and technology via 3D culture on basement membrane matrix. J Cell Physiol 221: 18-25.
25. Garraway LA, Lin D, Signoretti S, Waltregny D, Dilks J, et al. (2003) Intermediate basal cells of the prostate: in vitro and in vivo characterization. Prostate 55: 206-218.
26. Timms BG, (2008) Prostate development: a historical perspective. Differentiation 76: 565-577.
27. Ghosh S, Lau H, Simons BW, Powell JD, Meyers DJ, et al. (2011) PI3K/mTOR signaling regulates prostatic branching morphogenesis. Dev Biol 360: 329-342.
28. Goldstein AS, Huang J, Guo C, Garraway IP, Witte ON, (2010) Identification of a cell of origin for human prostate cancer. Science 329: 568-571.
29. Tilki D, Singer BB, Shariat SF, Behrend A, Fernando M, et al. (2010) CEACAM1: a novel urinary marker for bladder cancer detection. Eur Urol 57: 648-654.
30. Lauke H, Kilic N, Bozorgzad R, Fernando M, Neshat-Vahid S, et al. (2004) Expression of carcinoembryonic antigen-related cell adhesion molecule-1 (CEACAM1) in normal human Sertoli cells and its up-regulation in impaired spermatogenesis. Mol Hum Reprod 10: 247-252.
31. Klaile E, Vorontsova O, Sigmundsson K, Muller MM, Singer BB, et al. (2009) The CEACAM1 N-terminal Ig domain mediates cis- and trans-binding and is essential for allosteric rearrangements of CEACAM1 microclusters. J Cell Biol 187: 553-567.
32. Watt SM, Teixeira AM, Zhou GQ, Doyonnas R, Zhang Y, et al. (2001) Homophilic adhesion of human CEACAM1 involves N-terminal domain interactions: structural analysis of the binding site. Blood 98: 1469-1479.
33. Soifer HS, Koch T, Lai J, Hansen B, Hoeg A, et al. (2012) Silencing of gene expression by gymnotic delivery of antisense oligonucleotides. Methods Mol Biol 815: 333-346.
34. Hawley P, Gibson I, (1992) The detection of oligodeoxynucleotide molecules following uptake into mammalian cells. Antisense Res Dev 2: 119-127.
35. Dellinger DJ, Yamada CM, Caruthers MH, (2004) Oligodeoxyribonucleotide analogs functionalized with phosphonoacetate and thiophosphonoacetate diesters. Curr Protoc Nucleic Acid Chem Chapter 4: Unit 4 24.
36. Parsons JK, Gage WR, Nelson WG, De Marzo AM, (2001) p63 protein expression is rare in prostate adenocarcinoma: implications for cancer diagnosis and carcinogenesis. Urology 58: 619-624.
37. Lang SH, Stark M, Collins A, Paul AB, Stower MJ, et al. (2001) Experimental prostate epithelial morphogenesis in response to stroma and three-dimensional matrigel culture. Cell Growth Differ 12: 631-640.
38. Bello D, Webber MM, Kleinman HK, Wartinger DD, Rhim JS, (1997) Androgen responsive adult human prostatic epithelial cell lines immortalized by human papillomavirus 18. Carcinogenesis 18: 1215-1223.
39. Pearson JF, Hughes S, Chambers K, Lang SH, (2009) Polarized fluid movement and not cell death, creates luminal spaces in adult prostate epithelium. Cell Death Differ 16: 475-482.
40. Prins GS, Putz O, (2008) Molecular signaling pathways that regulate prostate gland development. Differentiation 76: 641-659.
41. Leung N, Turbide C, Balachandra B, Marcus V, Beauchemin N, (2008) Intestinal tumor progression is promoted by decreased apoptosis and dysregulated Wnt signaling in Ceacam1-/- mice. Oncogene 27: 4943-4953.