Overexpression and clinical significance of carcinoembryonic antigen-related cell adhesion molecule 6 in colorectal cancer

Clinica Chimica Acta

Volumn 415, Issue , 2013, Pages 12-19

  Kim, Kwang Soo ^a,b   Kim, Jong Tae ^a   Lee, Seon Jin ^a   Kang, Min Ah ^a   Choe, In Seong ^a   Kang, Yun Hee ^a   Kim, Seon Young ^a   Yeom, Young Il ^a   Lee, Young Ha ^b   Kim, Joo Heon ^c   Kim, Kyo Hyun ^c   Kim, Chang Nam ^c   Kim, Jong Wan ^d   Nam, Myoung Soo ^b   Lee, Hee Gu ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Chungnam National University   (South Korea)

^c Eulji University School of Medicine   (South Korea)

^d Dankook University College of Medicine   (South Korea)

Author keywords

Carcinoembryonic antigen related cell adhesion molecule 6; Colon cancer; Invasiveness; Microarray; Prognosis

Indexed keywords

CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 6; MESSENGER RNA; SMALL INTERFERING RNA;

ADULT; ARTICLE; CANCER INVASION; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 6 GENE; CLINICAL FEATURE; COLON MUCOSA; COLORECTAL CANCER; FEMALE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE SILENCING; GENETIC ANALYSIS; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MARKER GENE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECURRENCE FREE SURVIVAL; TISSUE MICROARRAY; TRANSCRIPTION REGULATION; TRANSLATION REGULATION; UPREGULATION;

ADENOCARCINOMA; ADULT; AGED; ANTIGENS, CD; CELL ADHESION MOLECULES; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GPI-LINKED PROTEINS; HUMANS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SURVIVAL ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 84866677862     PISSN: 00098981     EISSN: 18733492     Source Type: Journal    
DOI: 10.1016/j.cca.2012.09.003     Document Type: Article

References (30)

1. Parkin D.M., Bray F., Ferlay J., Pisani P. Global cancer statistics. CA Cancer J Clin 2002, 55:74-108.
2. Cunningham D., Atkin W., Lenz H.J., et al. Colorectal cancer. Lancet 2010, 375:1030-1047.
3. Gray-Owen S.D., Blumberg R.S. CEACAM1: contact-dependent control of immunity. Nat Rev Immunol 2006, 6:433-446.
4. Benchimol S., Fuks A., Jothy S., Beauchemin N., Shirota K., Stanners C.P. Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule. Cell 1989, 57:327-334.
5. Kuespert K., Pils S., Hauck C.R. CEACAMs: their role in physiology and pathophysiology. Curr Opin Cell Biol 2006, 18:565-571.
6. Gold P., Freedman S.O. Specific carcinoembryonic antigens of the human digestive system. J Exp Med 1965, 122:467-481.
7. Hammarstrom S. The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. Semin Cancer Biol 1999, 9:67-81.
8. Poola I., Shokrani B., Bhatnagar R., DeWitty R.L., Yue Q., Bonney G. Expression of carcinoembryonic antigen cell adhesion molecule 6 oncoprotein in atypical ductal hyperplastic tissue is associated with the development of invasive breast cancer. Clin Cancer Res 2006, 12:4773-4783.
9. Duxbury M.S., Ito H., Benoit E., Waseem T., Ashley S.W., Whang E.E. A novel role for carcinoembryonic antigen-related cell adhesion molecule 6 as a determinant of gemcitabine chemoresistance in pancreatic adenocarcinoma cells. Cancer Res 2004, 64:3987-3993.
10. Lasa A., Serrano E., Carricondo M., et al. High expression of CEACAM6 and CEACAM8 mRNA in acute lymphoblastic leukemias. Ann Hematol 2008, 87:205-211.
11. Plunkett T.A., Ellis P.A. CEACAM1: a marker with a difference or more of the same?. J Clin Oncol 2002, 20:4273-4275.
12. Blumenthal R.D., Hansen H.J., Goldenberg D.M. Inhibition of adhesion, invasion, and metastasis by antibodies targeting CEACAM6 (NCA-90) and CEACAM5 (carcinoembryonic antigen). Cancer Res 2005, 65:8809-8817.
13. Jantscheff P., Terracciano L., Lowy A., et al. Expression of CEACAM6 in resectable colorectal cancer: a factor of independent prognostic significance. J Clin Oncol 2003, 21:3638-3646.
14. Ordonez C., Screaton R.A., Ilantzis C., Stanners C.P. Human carcinoembryonic antigen functions as a general inhibitor of anoikis. Cancer Res 2000, 60:3419-3424.
15. Duxbury M.S., Ito H., Zinner M.J., Ashley S.W., Whang E.E. CEACAM6 gene silencing impairs anoikis resistance and in vivo metastatic ability of pancreatic adenocarcinoma cells. Oncogene 2004, 23:465-473.
16. Martin M.J., Melnyk N., Pollard M., et al. The insulin-like growth factor I receptor is required for Akt activation and suppression of anoikis in cells transformed by the ETV6-NTRK3 chimeric tyrosine kinase. Mol Cell Biol 2006, 26:1754-1769.
17. Ordonez C., Zhai A.B., Camacho-Leal P., Demarte L., Fan M.M., Stanners C.P. GPI-anchored CEA family glycoproteins CEA and CEACAM6 mediate their biological effects through enhanced integrin alpha5beta1-fibronectin interaction. J Cell Physiol 2007, 210:757-765.
18. Ilantzis C., DeMarte L., Screaton R.A., Stanners C.P. Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation. Neoplasia 2002, 4:151-163.
19. Birchmeier W., Behrens J. Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim Biophys Acta 1994, 1198:11-26.
20. Takeichi M. Cadherins in cancer: implications for invasion and metastasis. Curr Opin Cell Biol 1993, 5:806-811.
21. Frangsmyr L., Baranov V., Hammarstrom S. Four carcinoembryonic antigen subfamily members, CEA, NCA, BGP and CGM2, selectively expressed in the normal human colonic epithelium, are integral components of the fuzzy coat. Tumour Biol 1999, 20:277-292.
22. Scholzel S., Zimmermann W., Schwarzkopf G., Grunert F., Rogaczewski B., Thompson J. Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas. Am J Pathol 2000, 156:595-605.
23. Burtin P., Sabine M.C., Chavanel G. A comparative study of the localization of CEA and NCA2 in cancerous and normal gastrointestinal tissues. Int J Cancer 1977, 19:634-641.
24. Neumaier M., Paululat S., Chan A., Matthaes P., Wagener C. Biliary glycoprotein, a potential human cell adhesion molecule, is down-regulated in colorectal carcinomas. Proc Natl Acad Sci U S A 1993, 90:10744-10748.
25. Thompson J.A., Grunert F., Zimmermann W. Carcinoembryonic antigen gene family: molecular biology and clinical perspectives. J Clin Lab Anal 1991, 5:344-366.
26. Tokunaga N., Kijima H., Noto T., et al. Immunohistochemical localization of carcinoembryonic antigen as a predictor of lymph node status in submucosa-invasive colorectal carcinoma. Dis Colon Rectum 1995, 38:842-847.
27. Chevinsky A.H. CEA in tumors of other than colorectal origin. Semin Surg Oncol 1991, 7:162-166.
28. Lorenzi M., Vindigni C., Minacci C., et al. Histopathological and prognostic evaluation of immunohistochemical findings in colorectal cancer. Int J Biol Markers 1997, 12:68-74.
29. Cosimelli M., De Peppo F., Castelli M., et al. Multivariate analysis of a tissue CEA, TPA, and CA 19.9 quantitative study in colorectal cancer patients: a preliminary finding. Dis Colon Rectum 1989, 32:389-397.
30. Bos M.P., Grunert F., Belland R.J. Differential recognition of members of the carcinoembryonic antigen family by Opa variants of Neisseria gonorrhoeae. Infect Immun 1997, 65:2353-2361.