Prognostic significance of CTCs and CSCs of tumor drainage vein blood in Dukes' stage B and C colorectal cancer patients

Oncology Reports

Volumn 27, Issue 4, 2012, Pages 947-953

  Shimada, Ryu ^a   Iinuma, Hisae ^a   Akahane, Takuya ^a   Horiuchi, Atsushi ^a   Watanabe, Toshiaki ^a  

^a TEIKYO UNIVERSITY   (Japan)

Author keywords

Cancer stem cell; CD133; CEA; Circulating tumor cells; CK19; CK20; Colorectal cancer; Tumor drainage vein blood

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; CD133 ANTIGEN; CYTOKERATIN 19; CYTOKERATIN 20;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CANCER PROGNOSIS; CANCER STAGING; CANCER STEM CELL; CELL FUNCTION; CELLULAR DISTRIBUTION; CIRCULATING TUMOR CELL; CLINICAL EFFECTIVENESS; COLORECTAL CANCER; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE FREE SURVIVAL; DISEASE MARKER; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MARKER GENE; OVERALL SURVIVAL; PATHOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RISK FACTOR; TUMOR DRAINAGE VENOUS BLOOD; VENOUS BLOOD;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD; CARCINOEMBRYONIC ANTIGEN; COLORECTAL NEOPLASMS; DISEASE-FREE SURVIVAL; FEMALE; GLYCOPROTEINS; HUMANS; JAPAN; KAPLAN-MEIER ESTIMATE; KERATIN-19; KERATIN-20; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM STAGING; NEOPLASTIC CELLS, CIRCULATING; NEOPLASTIC STEM CELLS; PEPTIDES; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RISK ASSESSMENT; RISK FACTORS; RNA, MESSENGER; TIME FACTORS; TUMOR MARKERS, BIOLOGICAL; VEINS;

EID: 84863043341     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.1649     Document Type: Article

References (26)

1. Parkin DM: Global cancer statistics in the year 2000. Lancet Oncol 2: 533-543, 2001.
2. Winawer S, Fletcher R, Rex D, et al: Colorectal cancer screening and surveillance: clinical guidelines and rationale-Update based on new evidence. Gastroenterology 124: 544-560, 2003. (Pubitemid 36169269)
3. Compton CC, Fielding LP, Burgart LJ, et al: Prognostic factors in colorectal cancer. College of American Pathologists Consensus Statement 1999. Arch Pathol Lab Med 124: 979-994, 2000. (Pubitemid 30602039)
4. Guerra A, Borda F, Javier Jimenez F, Martinez-Penuela JM and Larrinaga B: Multivariate analysis of prognostic factors in resected colorectal cancer: a new prognostic index. Eur J Gastroenterol Hepatol 10: 51-58, 1998. (Pubitemid 28085500)
5. Hundt S, Haug U and Brenner H: Blood markers for early detection of colorectal cancer: a systematic review. Cancer Epidemiol Biomarkers Prev 16: 1935-1953, 2007. (Pubitemid 47621167)
6. Chung KY and Kelsen D: Adjuvant therapy for stage II colorectal cancer; who and with what? Cut Treat Options Gastroenterol 9: 272-280, 2006.
7. Wang Y, Jatokoe T, Zhang Y, et al: Gene expression profiles and molecular markers to predict recurrence of Dukes' B colon cancer. J Clin Oncol 22: 1564-1571, 2004. (Pubitemid 41079793)
8. Engell HC: Cancer cells in the circulating blood; a clinical study on the occurrence of cancer cells in the peripheral blood and in venous blood draining the tumor area at operation. Ugeskr Laeger 117: 822-823, 1995.
9. Iinuma H, Okinaga K, Egami H, et al: Usefulness and clinical significance of quantitative real-time RT-PCR to detect isolated tumor cells in the peripheral blood and tumor drainage blood of patients with colorectal cancer. Int J Oncol 28: 297-306, 2006.
10. Peach G, Kim C, Zacharakis E, Purkayastha S and Ziprin P: Prognostic significance of circulating tumour cells following surgical resection of colorectal cancers: a systematic review. Br J Cancer 102: 1327-1334, 2010.
11. Riethdorf S, Wikman H and Pantel K: Biological relevance of disseminated tumor cells in cancer patients. Int J Cancer 123: 1991-2006, 2008.
12. Tol J, Koopman M, Miller MC, et al: Circulating tumour cells early predict progression-free and overall survival in advanced colorectal cancer patients treated with chemotherapy and targeted agents. Ann Oncol 21: 1006-1012, 2010.
13. Yen LC, Yeh YS, Chen CW, et al: Detection of KRAS oncogene in peripheral blood as a predictor of the response to cetuximab plus chemotherapy in patients with metastatic colorectal cancer.Clin Cancer 15: 4508-4513, 2009.
14. De Bono JS, Attard G, Adjei A, et al: Potential applications for circulating tumor cells expressing the insulin-like growth factor-I receptor. Clin Cancer 13: 3611-3616, 2007. (Pubitemid 46955123)
15. Thorsteinsson M and Jess P: The clinical significance of circulating tumor cells in non-metastatic colorectal cancer: a review. Eur J Surg Oncol 37: 459-465, 2011.
16. Iinuma H, Watanabe T, Mimori K, et al: Clinical significance of circulating tumor cells, including cancer stem-like cells, in peripheral blood for recurrence and prognosis in patients with Dukes' stage B and C colorectal cancer. J Clin Oncol 29: 1547-1555, 2011.
17. Visvader JE and Lindeman GJ: Cancer stem cells in solid tumors:accumulating evidence and unresolved questions. Nat Rev Cancer 8: 755-758, 2008.
18. Todaro M, Francipane MG, Medema JP and Stassi G: Colon cancer stem cells: promise of targeted therapy. Gastroenterology 138: 2151-2162, 2010.
19. Aktas B, Tewes M, Fehm T, Hauch S, Kimmig R and Kasimir-Bauer S: Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients. Breast Cancer Res 11: R46, 2009.
20. Balic M, Lin H, Young L, et al: Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype. Clin Cancer 12: 5615-5621, 2006. (Pubitemid 44629587)
21. Sergeant G, Penninckx F and Topal B: Quantitative RT-PCR detection of colorectal tumor cells in peripheral blood: a systematic review. J Surg Res 150: 144-152, 2008.
22. O'Brien CA, Pollett A, Gallinger S and Dick JE: A human colon cancer cell capable of initiating tumor growth in immunodeficient mice. Nature 445: 106-110, 2007. (Pubitemid 46067310)
23. Ricci-Vitiani L, Lombardi DG, Pilozzi E, Biffoni M, Todaro M, Peschle C and De Maria R: Identification and expansion of human colon-cancer-initiating cells. Nature 445: 111-115, 2007. (Pubitemid 46067311)
24. Richardson GD, Robson CN, Lang SH, et al: CD133, a novel marker for human prostatic epithelial stem cells. J Cell Sci 117: 3539-3545, 2004. (Pubitemid 39206394)
25. Lugli A, Iezzi G, Hostettler I, et al: Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer. Br J Cancer 103: 382-390, 2010.
26. Rahbari NN, Aigner M, Thorlund K, et al: Meta-analysis shows that detection of circulating tumor cells indicates poor prognosis in patients with colorectal cancer. Gastroenterology 138: 1714-1726, 2010.