CEACAM1 enhances invasion and migration of melanocytic and melanoma cells

American Journal of Pathology

Volumn 165, Issue 5, 2004, Pages 1781-1787

  Ebrahimnejad, Alireza ^a   Streichert, Thomas ^a   Nollau, Peter ^a   Horst, Andrea K ^a   Wagener, Christoph ^a   Bamberger, Ana Maria ^a   Brümmer, Jens ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA5 INTEGRIN; ARGINYLGLYCYLASPARTIC ACID; BETA3 INTEGRIN; CELL ADHESION MOLECULE; MONOCLONAL ANTIBODY;

ARTICLE; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; CYTOPLASM; DOSE RESPONSE; HUMAN; HUMAN CELL; MELANOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

EID: 7244254254     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63433-5     Document Type: Article

References (35)

1. Edward M: Integrins and other adhesion molecules involved in melanocytic tumor progression. Curr Opin Oncol 1995, 7:185-191
2. Buttner P, Garbe C, Bertz J, Burg G, d'Hoedt B, Drepper H, Guggenmoos-Holzmann I, Lechner W, Lippold A, Orfanos CE, Peters A, Rassner G, Stadler R, Stroebel W: Primary cutaneous melanoma. Optimized cutoff points of tumor thickness and importance of Clark's level for prognostic classification. Cancer 1995, 75:2499-2506
3. Johnson JP: Cell adhesion molecules in the development and progression of malignant melanoma. Cancer Metastasis Rev 1999, 18:345-357
4. Natali PG, Hamby CV, Felding-Habermann B, Liang B, Nicotra MR, Di Filippo F, Giannarelli D, Temponi M, Ferrone S: Clinical significance of alpha(v)beta3 integrin and intercellular adhesion molecule-1 expression in cutaneous malignant melanoma lesions. Cancer Res 1997, 57:1554-1560
5. Hsu MY, Shih DT, Meier FE, Van Belle P, Hsu JY, Elder DE, Buck CA, Herlyn M: Adenoviral gene transfer of beta3 integrin subunit induces conversion from radial to vertical growth phase in primary human melanoma. Am J Pathol 1998, 153:1435-1442
6. Mitjans F, Sander D, Adan J, Sutter A, Martinez JM, Jaggle CS, Moyano JM, Kreysch HG, Piulats J, Goodman SL: An anti-alpha v-integrin antibody that blocks integrin function inhibits the development of a human melanoma in nude mice. J Cell Sci 1995, 108:2825-2838
7. Xie S, Luca M, Huang S, Gutman M, Reich R, Johnson JP, Bar-Eli M: Expression of MCAM/MUC18 by human melanoma cells leads to increased tumor growth and metastasis. Cancer Res 1997, 57:2295-2303
8. Mills L, Tellez C, Huang S, Baker C, McCarty M, Green L, Gudas JM, Feng X, Bar-Eli M: Fully human antibodies to MCAM/MUC18 inhibit tumor growth and metastasis of human melanoma. Cancer Res 2002, 62:5106-5114
9. Hendrix MJ, Seftor EA, Hess AR, Seftor RE: Molecular plasticity of human melanoma cells. Oncogene 2003, 22:3070-3075
10. Thies A, Moll I, Berger J, Wagener C, Brummer J, Schulze HJ, Brunner G, Schumacher U: CEACAM1 expression in cutaneous malignant melanoma predicts the development of metastatic disease. J Clin Oncol 2002, 20:2530-2536
11. Wagener C, Clark BR, Rickard KJ, Shively JE: Monoclonal antibodies for carcinoembryonic antigen and related antigens as a model system: determination of affinities and specificities of monoclonal antibodies by using biotin-labeled antibodies and avidin as precipitating agent in a solution phase immunoassay. J Immunol 1983, 130:2302-2307
12. Neumaier M, Fenger U, Wagener C: Monoclonal antibodies for carcinoembryonic antigen (CEA) as a model system: identification of two novel CEA-related antigens in meconium and colorectal carcinoma tissue by Western blots and differential immunoaffinity chromatography. J Immunol 1985, 135:3604-3609
13. Brummer J, Neumaier M, Gopfert C, Wagener C: Association of pp60c-src with biliary glycoprotein (CD66a), an adhesion molecule of the carcinoembryonic antigen family downregulated in colorectal carcinomas. Oncogene 1995, 11:1649-1655
14. Ebrahimnejad A, Flayeh R, Unteregger G, Wagener C, Brummer J: Cell adhesion molecule CEACAM1 associates with paxillin in granulocytes and epithelial and endothelial cells. Exp Cell Res 2000, 260:365-373
15. Brummer J, Ebrahimnejad A, Flayeh R, Schumacher U, Loning T, Bamberger AM, Wagener C: Cis interaction of the cell adhesion molecule CEACAM1 with integrin beta(3). Am J Pathol 2001, 159:537-546
16. Schmidt NO, Westphal M, Hagel C, Ergun S, Stavrou D, Rosen EM, Lamszus K: Levels of vascular endothelial growth factor, hepatocyte growth factor/scatter factor and basic fibroblast growth factor in human gliomas and their relation to angiogenesis. Int J Cancer 1999, 84:10-18
17. Rajagopalan D: A comparison of statistical methods for analysis of high density oligonucleotide array data. Bioinformatics 2003, 19:1469-1476
18. Beauchemin N, Kunath T, Robitailie J, Chow B, Turbide C, Daniels E, Veillette A: Association of biliary glycoprotein with protein tyrosine phosphatase SHP-1 in malignant colon epithelial cells. Oncogene 1997, 14:783-790
19. Huber M, Izzi L, Grondin P, Houde C, Kunath T, Veillette A, Beauchemin N: The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells. J Biol Chem 1999, 274:335-344
20. Gehlsen KR, Argraves WS, Pierschbacher MD, Ruoslahti E: Inhibition of in vitro tumor cell invasion by Arg-Gly-Asp-containing synthetic peptides. J Cell Biol 1988, 106:925-930
21. Busch C, Hanssen TA, Wagener C, Obrink B: Down-regulation of CEACAM1 in human prostate cancer: correlation with loss of cell polarity, increased proliferation rate, and Gleason grade 3 to 4 transition. Hum Pathol 2002, 33:290-298
22. Nollau P, Scheller H, Kona-Horstmann M, Ronde S, Hagenmuller F, Wagener C, Neumaier M: Expression of CD66a (human C-CAM) and other members of the carcinoembryonic antigen gene family of adhesion molecules in human colorectal adenomas. Cancer Res 1997, 57:2354-2357
23. Kinugasa T, Kuroki M, Takeo H, Matsuo Y, Ohshima K, Yamashita Y, Shirakusa T, Matsuoka Y: Expression of four CEA family antigens (CEA, NCA, BGP and CGM2) in normal and cancerous gastric epithelial cells: up-regulation of BGP and CGM2 in carcinomas. Int J Cancer 1998, 76:148-153
24. Ohwada A, Takahashi H, Nagaoka I, Kira S: Biliary glycoprotein mRNA expression is increased in primary lung cancer, especially in squamous cell carcinoma. Am J Respir Cell Mol Biol 1994, 11:214-220
25. Laack E, Nikbakht H, Peters A, Kugler C, Jasiewicz Y, Edler L, Brummer J, Schumacher U, Hossfeld DK: Expression of CEACAM1 in adenocarcinoma of the lung: a factor of independent prognostic significance. J Clin Oncol 2002, 20:4279-4284
26. Sienel W, Dango S, Woelfle U, Morresi-Hauf A, Wagener C, Brummer J, Mutsohler W, Passlick B, Pantel K: Elevated expression of carcinoembryonic antigen-related cell adhesion molecule 1 promotes progression of non-small cell lung cancer. Clin Cancer Res 2003, 9:2260-2266
27. Obrink B: CEA adhesion molecules: multifunctional proteins with signal-regulatory properties, Curr Opin Cell Biol 1997, 9:616-626
28. Kirshner J, Chen CJ, Liu P, Huang J, Shively JE: CEACAM1-4S, a cell-cell adhesion molecule, mediates apoptosis and reverts mammary carcinoma cells to a normal morphogenic phenotype in a 3D culture, Proc Natl Acad Sci USA 2003, 100:521-526
29. Luo W, Wood CG, Earley K, Hung MC, Lin SH: Suppression of tumorigenicity of breast cancer cells by an epithelial cell adhesion molecule (C-CAM1): the adhesion and growth suppression are mediated by different domains. Oncogene 1997, 14:1697-1704
30. Izzi L, Turbide C, Houde C, Kunath T, Beauchemin N: Cis-determinants in the cytoplasmic domain of CEACAM1 responsible for its tumor inhibitory function. Oncogene 1999, 18:5563-5572
31. Schwartz MA, Ginsberg MH: Networks and crosstalk: integrin signalling spreads. Nat Cell Biol 2002, 4:E65-E68
32. Bamberger AM, Sudahl S, Loning T, Wagener C, Bamberger CM, Drakakis P, Coutifaris C, Makrigiannakis A: The adhesion molecule CEACAM1 (CD66a, C-CAM, BGP) is specifically expressed by the extravillous intermediate trophoblast. Am J Pathol 2000, 156:1165-1170
33. Hynes RO: Integrins: bidirectional, allosteric signaling machines. Cell 2002, 110:673-687
34. Hood JD, Cheresh DA: Role of integrins in cell invasion and migration. Nat Rev Cancer 2002, 2:91-100
35. Markel G, Wolf D, Hanna J, Gazit R, Goldman-Wohl D, Lavy Y, Yagel S, Mandelboim O: Pivotal role of CEACAM1 protein in the inhibition of activated decidual lymphocyte functions. J Clin Invest 2002, 110:943-953