A novel Anti-CEACAM5 Monoclonal antibody, CC4, suppresses colorectal tumor growth and enhances NK cells-mediated tumor immunity

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  Zheng, Chaogu ^a   Feng, Jing ^a   Lu, Di ^a   Wang, Ping ^a   Xing, Shu ^a   Coll, Jean Luc ^b   Yang, Dongling ^a   Yan, Xiyun ^a  

^a INSTITUTE OF BIOPHYSICS   (China)

^b INSTITUT ALBERT BONNIOT   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 1; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 5; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CC4; UNCLASSIFIED DRUG; ANTIGEN; CARCINOEMBRYONIC ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER INHIBITION; CANCER TISSUE; CELL AGGREGATION; COLORECTAL CANCER; COLORECTAL CARCINOMA; CONTROLLED STUDY; DRUG EFFICACY; DRUG TARGETING; DRUG TUMOR LEVEL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MIGRATION INHIBITION; MITOSIS INHIBITION; MOLECULAR INTERACTION; MOUSE; NATURAL KILLER CELL; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; NONHUMAN; TREATMENT DURATION; TUMOR ESCAPE; TUMOR IMMUNITY; TUMOR XENOGRAFT; AMINO ACID SEQUENCE; ANIMAL; ANTIBODY SPECIFICITY; CELL MOTION; CELL PROLIFERATION; CELLULAR IMMUNITY; CHEMISTRY; COLORECTAL TUMOR; CYTOLOGY; DRUG SCREENING; EPITOPE MAPPING; IMMUNOLOGY; MOLECULAR GENETICS; PATHOLOGY;

MUS;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; ANTIGENS; CARCINOEMBRYONIC ANTIGEN; CELL AGGREGATION; CELL MOVEMENT; CELL PROLIFERATION; COLORECTAL NEOPLASMS; EPITOPE MAPPING; HUMANS; IMMUNITY, CELLULAR; KILLER CELLS, NATURAL; MICE; MOLECULAR SEQUENCE DATA; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79959425426     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0021146     Document Type: Article

References (33)

1. Gold P, Freedman SO, (1965) Specific carcinoembryonic antigens of the human digestive system. J Exp Med 122: 467-481.
2. Thompson JA, Grunert F, Zimmermann W, (1991) Carcinoembryonic antigen gene family: molecular biology and clinical perspectives. J Clin Lab Anal 5: 344-366.
3. Hostetter RB, Campbell DE, Chi KF, Kerckhoff S, Cleary KR, et al. (1990) Carcinoembryonic antigen enhances metastatic potential of human colorectal carcinoma. Arch Surg 125: 300-304.
4. Hashino J, Fukuda Y, Oikawa S, Nakazato H, Nakanishi T, (1994) Metastatic potential of human colorectal carcinoma SW1222 cells transfected with cDNA encoding carcinoembryonic antigen. Clin Exp Metastasis 12: 324-328.
5. Hammarstrom S, (1999) The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. Semin Cancer Biol 9: 67-81.
6. Duffy MJ, (2001) Carcinoembryonic antigen as a marker for colorectal cancer: is it clinically useful? Clin Chem 47: 624-630.
7. Taheri M, Saragovi U, Fuks A, Makkerh J, Mort J, et al. (2000) Self recognition in the Ig superfamily. Identification of precise subdomains in carcinoembryonic antigen required for intercellular adhesion. J Biol Chem 275: 26935-26943.
8. Ordonez C, Screaton RA, Ilantzis C, Stanners CP, (2000) Human carcinoembryonic antigen functions as a general inhibitor of anoikis. Cancer Res 60: 3419-3424.
9. Ilantzis C, DeMarte L, Screaton RA, Stanners CP, (2002) Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation. Neoplasia 4: 151-163.
10. Chan CH, Cook D, Stanners CP, (2006) Increased colon tumor susceptibility in azoxymethane treated CEABAC transgenic mice. Carcinogenesis 27: 1909-1916.
11. Chan CH, Camacho-Leal P, Stanners CP, (2007) Colorectal hyperplasia and dysplasia due to human carcinoembryonic antigen (CEA) family member expression in transgenic mice. PLoS ONE 2: e1353.
12. Mayer A, Chester KA, Flynn AA, Begent RH, (1999) Taking engineered anti-CEA antibodies to the clinic. J Immunol Methods 231: 261-273.
13. Chester KA, Mayer A, Bhatia J, Robson L, Spencer DI, et al. (2000) Recombinant anti-carcinoembryonic antigen antibodies for targeting cancer. 46 (Suppl) Cancer Chemother Pharmacol: S8-12.
14. Sharma SK, Boden JA, Springer CJ, Burke PJ, Bagshawe KD, (1994) Antibody-directed enzyme prodrug therapy (ADEPT). A three-phase study in ovarian tumor xenografts. Cell Biophys 24-25: 219-228.
15. Xu X, Clarke P, Szalai G, Shively JE, Williams LE, et al. (2000) Targeting and therapy of carcinoembryonic antigen-expressing tumors in transgenic mice with an antibody-interleukin 2 fusion protein. Cancer Res 60: 4475-4484.
16. Gray-Owen SD, Blumberg RS, (2006) CEACAM1: contact-dependent control of immunity. Nat Rev Immunol 6: 433-446.
17. Markel G, Lieberman N, Katz G, Arnon TI, Lotem M, et al. (2002) CD66a interactions between human melanoma and NK cells: a novel class I MHC-independent inhibitory mechanism of cytotoxicity. J Immunol 168: 2803-2810.
18. Stern N, Markel G, Arnon TI, Gruda R, Wong H, et al. (2005) Carcinoembryonic antigen (CEA) inhibits NK killing via interaction with CEA-related cell adhesion molecule 1. J Immunol 174: 6692-6701.
19. Blumenthal RD, Osorio L, Hayes MK, Horak ID, Hansen HJ, et al. (2005) Carcinoembryonic antigen antibody inhibits lung metastasis and augments chemotherapy in a human colonic carcinoma xenograft. Cancer Immunol Immunother 54: 315-327.
20. Benchimol S, Fuks A, Jothy S, Beauchemin N, Shirota K, et al. (1989) Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule. Cell 57: 327-334.
21. Stein R, Goldenberg DM, (2004) A humanized monoclonal antibody to carcinoembryonic antigen, labetuzumab, inhibits tumor growth and sensitizes human medullary thyroid cancer xenografts to dacarbazine chemotherapy. Mol Cancer Ther 3: 1559-1564.
22. Imakiire T, Kuroki M, Shibaguchi H, Abe H, Yamauchi Y, et al. (2004) Generation, immunologic characterization and antitumor effects of human monoclonal antibodies for carcinoembryonic antigen. Int J Cancer 108: 564-570.
23. Gasparini M, Ripamonti M, Seregni E, Regalia E, Buraggi GL, (1988) Tumor imaging of colo-rectal carcinoma with an anti-CEA monoclonal antibody. Int J Cancer Suppl 2 pp. 81-84.
24. Bading JR, Horling M, Williams LE, Colcher D, Raubitschek A, et al. (2008) Quantitative serial imaging of an 124I anti-CEA monoclonal antibody in tumor-bearing mice. Cancer Biother Radiopharm 23: 399-409.
25. Taheri M, Saragovi HU, Stanners CP, (2003) The adhesion and differentiation-inhibitory activities of the immunoglobulin superfamily member, carcinoembryonic antigen, can be independently blocked. J Biol Chem 278: 14632-14639.
26. Dunn GP, Old LJ, Schreiber RD, (2004) The immunobiology of cancer immunosurveillance and immunoediting. Immunity 21: 137-148.
27. Seliger B, (2008) Molecular mechanisms of MHC class I abnormalities and APM components in human tumors. Cancer Immunol Immunother 57: 1719-1726.
28. Waldhauer I, Steinle A, (2008) NK cells and cancer immunosurveillance. Oncogene 27: 5932-5943.
29. Blumenthal RD, Leon E, Hansen HJ, Goldenberg DM, (2007) Expression patterns of CEACAM5 and CEACAM6 in primary and metastatic cancers. BMC Cancer 7: 2.
30. Kohler G, Milstein C, (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256: 495-497.
31. Gharahdaghi F, Weinberg CR, Meagher DA, Imai BS, Mische SM, (1999) Mass spectrometric identification of proteins from silver-stained polyacrylamide gel: a method for the removal of silver ions to enhance sensitivity. Electrophoresis 20: 601-605.
32. Takeichi M, (1977) Functional correlation between cell adhesive properties and some cell surface proteins. J Cell Biol 75: 464-474.
33. Jin ZH, Josserand V, Razkin J, Garanger E, Boturyn D, et al. (2006) Noninvasive optical imaging of ovarian metastases using Cy5-labeled RAFT-c(-RGDfK-)4. Mol Imaging 5: 188-197.