Protein epitopes in carcinoembryonic antigen: Report of the ISOBM TD8 Workshop

Tumor Biology

Volumn 23, Issue 4, 2002, Pages 249-262

  Bjerner, Johan ^a   Lebedin, Yuri ^b   Bellanger, Laurent ^c   Kuroki, Masahide ^d   Shively, John E ^e   Varaas, Tone ^a   Nustad, Kjell ^a   Hammarström, Sten ^f   Børmer, Ole P ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b Xema Medica Co Ltd   (Russian Federation)

^c CIS Bio International   (France)

^d FUKUOKA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^f UMEÅ UNIVERSITY   (Sweden)

Author keywords

Carcinoembryonic antigen; Epitopes; Monoclonal antibody

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; EPITOPE; MONOCLONAL ANTIBODY;

ARTICLE; BINDING AFFINITY; COLON TUMOR; COLORECTAL CARCINOMA; IMMUNOASSAY; IMMUNORADIOMETRIC ASSAY; LIVER METASTASIS; MECONIUM; PRIORITY JOURNAL; RNA TRANSLATION;

EID: 0036957118     PISSN: 10104283     EISSN: None     Source Type: Journal    
DOI: 10.1159/000067255     Document Type: Article

References (31)

1. Gold P, Freedman SO: Demonstration of tumor-specific antigens in human colon carcinomata by immunological tolerance and absorption techniques. J Exp Med 1965;121:439-462.
2. Zimmermann W, Ortlieb B, Friedrich R, von Kleist S: Isolation and characterization of cDNA clones encoding the human carcinoem-bryonic antigen reveal a highly conserved repeating structure. Proc Natl Acad Sci USA 1987;84:2960-2964.
3. Oikawa S, Nakazato H, Kosaki G: Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence. Biochem Biophys Res Commun 1987;142:511-518.
4. Beauchemin N, Benchimol S, Cournoyer D, Fuks A, Stanners CP: Isolation and characterization of full-length functional cDNA clones for human carcinoembryonic antigen (CEA). Mol Cell Biol 1987;7:3221-3230.
5. Kamarck ME, Elting JJ, Hart JT, Goebel SJ, Rae PM, Nothdurft MA, Nedwin JJ, Barnett TR: Carcinoembryonic antigen family: Expression in a mouse L-cell transfectant and characterization of a partial cDNA in bacteriophage λ-gt11. Proc Natl Acad Sci USA 1987;84:5350-5354.
6. Hammarström S, Shively JE, Paxton RJ, Beatty BG, Larsson A, Ghosh R, Bormer O, Buchegger F, Mach JP, Burtin P, seguin P, Darbouret B, Degorce F, Sertour J, Jolu JP, Fuks A, Kalthoff H, Schmiegel W, Arndt R Kloppel G, von Kleist S, Grunert F, Schwartz K, Matsuoka Y, Kuroki M, Wagener C, Weber T, Yachi A, Imai K, Hishikawa N, Tsujisaki M: Antigenic sites in carcinoembryonic antigen. Cancer Res 1989;49:4852-4858.
7. Boehm MK, Mayans MO, Thornton JD, Begent RH, Keep PA, Perkins SJ: Extended glycoprotein structure of the seven domains in human carcinoembryonic antigen by X-ray and neutron solution scattering and an automated curve fitting procedure: Implications for cellular adhesion. J Mol Biol 1996;259:718-736.
8. Hefta SA, Hefta LJF, Lee TD, Paxton RJ, Shively JE: Carcinoembryonic antigen is anchored to membranes by covalent attachment to a glycosylphosphatidylinositol moiety: Identification of the ethanolamine linkage site. Proc Natl Acad Sci USA 1988;85:4648-4652.
9. Thompson JA: Molecular cloning and expression of carcinoembryonic antigen gene family members. Tumor Biol 1995;16:10-16.
10. Hammarström S: The carcinoembryonic antigen (CEA) family: Structures, suggested functions and expression in normal and malignant tissues. Semin Cancer Biol 1999;9:67-81.
11. Thompson J, Zimmermann W, Osthus-Bugat P, Schleussner C, Eades-Perner AM, Barnert S, von Kleist S, Willcocks T, Craig I, Tynan K, Olsen A, Mohrenweiser H: Long-range chromosomal mapping of the carcinoembryonic antigen (CEA) gene family cluster. Genomics 1992;12:761-772.
12. Beauchemin N, Draber P, Dveksler G, Gold P, Gray-Owen S, Grunert F, Hammarstrom S, Holmes KV, Karlsson A, Kuroki M, Lin SH, Lucka L, Najjar SM, Neumaier M, Obrink B, Shively JE, Skubitz KM, Stanners CP, Thomas P, Thompson JA, Virji M, von Kleist S, Wagener C, Watt S, Zimmermann W: Redefined nomenclature for members of the carcinoembryonic family. Exp Cell Res 1999;243-249.
13. von Kleist S, Chavanel G, Burtin P: Identification of an antigen from normal human tissue that cross-reacts with the carcinoembryonic antigen. Proc Natl Acad Sci USA 1972;69:2492-2494.
14. Svenberg T: Carcinoembryonic antigen-like substances of human bile. Isolation and partial characterization. Int J Cancer 1976;17:588-596.
15. Hinoda Y, Neumaier M, Hefta SA, Drzeniek Z, Wagener C, Shively L, Hefta LJ, Shively JE, Paxton RJ: Molecular cloning of a cDNA coding biliary glycoprotein I: Primary structure of a glycoprotein immunologically crossreactive with carcinoembryonic antigen. Proc Natl Acad Sci USA 1988;85:6959-6963.
16. Murakami M, Kuroki M, Arakawa F, Kuwahara M, Oikawa S, Nakazato H, Matsuoka Y: A reference of the GOLD classification of monoclonal antibodies against carcinoembryonic antigen to the domain structure of the carcinoembryonic antigen molecule. Hybridoma 1995;14:19-28.
17. Burtin P, Chavanel G, Hirsch-Marie H: Characterization of a second normal antigen that cross-reacts with CEA. J Immunol 1973;111:1926-1928.
18. Suzuki N, Kondo K, Tominaga S, Kuroki M, Matsuoka Y: Heterogeneity of circulating carcinoembryonic antigen analyzed by sandwichenzyme immunoassays with different specificities. Cancer Res 1987;47:4782-4787.
19. Siepen D, Paxton RJ, Neumaier M: Carcinoembryonic antigen (CEA) and two crossreactive antigens of 165 kD and 105 kD exhibit identical aminoterminal sequences. Biochem Biophys Res Commun 1987;147:212-218.
20. Yamashita K, Totani K, Kuroki M, Matsuoka Y, Ueda I, Kobata A: Structural studies of the carbohydrate moieties of carcinoembryonic antigens. Cancer Res 1987;47:3451-3459.
21. Yamashita K, Totani K, Iwaki Y, Kuroki M, Matsuoka Y, Endo T, Kobata A: Carbohydrate structures of nonspecific cross-reacting antigen-2, a glycoprotein purified from meconium as an antigen cross-reacting with anticarcinoembryonic antigen antibody. J Biol Chem 1989;264:17873-17881.
22. Børmer O: A direct assay for carcinoembryonic antigen in serum and its diagnostic value in metastatic breast cancer. Clin Biochem 1982;15:128-132.
23. Børmer OP: Major disagreement between immunoassays of carcinoembryonic antigen may be caused by nonspecific cross-reacting antigen 2 (NCA-2). Clin Chem 1991;37:1736-1739.
24. Børmer OP, Nustad K: Selection of monoclonal antibodies for use in an immunometric assay for carcinoembryonic antigen. J Immunol Methods 1990;127:171-178.
25. Nap M, Hammarstrom ML, Bormer O, Hammarstrom S, Wagener C, Handt S, Schreyer M, Mach JP, Buchegger F, von Kleist S, Grunert F, Seguin P, Fuks A, Holm R, Lamerz R: Specificity and affinity of monoclonal antibodies against carcinoembryonic antigen. Cancer Res 1992;52:2329-2339.
26. Hedin A, Zoubir F, Lundgren T, Hammarström S: Epitope specificity and cross-reactivity pattern of a large series of monoclonal antibodies to carcinoembryonic antigen. Mol Immunol 1986;23:1053-1061.
27. Kuroki M, Murakami M, Wakisaka M, Krop-Watorek A, Oikawa S, Nakazato H, Kosaki G, Matsuoka Y: Epitopes predominantly retained on the carcinoembryonic antigen molecules in plasma of patients with malignant tumors but not on those in plasma of normal individuals. Jpn J Cancer Res 1992;83:505-514.
28. Mach J-P, Buchegger F, Forni M, Ritschard J, Berche C, Lumbroso J-D, Schreyer M, Girardet C, Accola RS, Carrel S: Use of radiolabelled monoclonal anti-CEA antibodies for the detection of human carcinomas by external photoscanning and tomoscintigraphy. Immunol Today 1981;2:239-249.
29. von Kleist S, Troupel S, King M, Burtin P: A clinical comparison between non-specific cross-reacting antigen and CEA in patients' sera. Br J Cancer 1977;35:875-880.
30. Wahren B, Gahrton G, Hammarström S: Non-specific cross-reacting antigen in normal and myeloid cells and serum of leukemic patients. Cancer Res 1980;40:2039-2044.
31. r 128,000 in serum. J Clin Chem Clin Biochem 1989;27:643-652.