메뉴 건너뛰기




Volumn , Issue , 2006, Pages 221-243

Stimulation of Antigen Presenting Cells: From Classical Adjuvants to Toll-like Receptor (TLR) Ligands

Author keywords

Antigen presenting cells; Composition of adjuvants; Efficient immune responses; Function of adjuvants; Ligands recognized by T and toll like receptors (TLR); Pathogen associated features; Stimulation of antigen presenting cells; Synopsis; Therapeutic potential of TLRs ligands; TLR protein family in mammals; TLR signaling

Indexed keywords


EID: 84889424022     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/3527607021.ch8     Document Type: Chapter
Times cited : (1)

References (101)
  • 2
    • 0031884839 scopus 로고    scopus 로고
    • The duration of antigenic stimulation determines the fate of naive and effector Tcells
    • Iezzi, G., K. Karjalainen, and A. Lanzavecchia. 1998. The duration of antigenic stimulation determines the fate of naive and effector Tcells. Immunity 8: 89-95.
    • (1998) Immunity , vol.8 , pp. 89-95
    • Iezzi, G.1    Karjalainen, K.2    Lanzavecchia, A.3
  • 3
    • 0038445969 scopus 로고    scopus 로고
    • Innate immunity together with duration of antigen persistence regulate effector T cell induction
    • Storni, T., C. Ruedl, W.A. Renner, and M.F. Bachmann. 2003. Innate immunity together with duration of antigen persistence regulate effector T cell induction. J. Immunol. 171: 795-801.
    • (2003) J. Immunol. , vol.171 , pp. 795-801
    • Storni, T.1    Ruedl, C.2    Renner, W.A.3    Bachmann, M.F.4
  • 5
    • 0035015319 scopus 로고    scopus 로고
    • Ficolins and the lectin complement pathway
    • Matsushita, M., and T. Fujita. 2001. Ficolins and the lectin complement pathway. Immunol. Rev. 180: 78-85.
    • (2001) Immunol. Rev. , vol.180 , pp. 78-85
    • Matsushita, M.1    Fujita, T.2
  • 8
    • 3142779901 scopus 로고    scopus 로고
    • Therapeutics targeting the innate immune system
    • Ulevitch, R.J. 2004. Therapeutics targeting the innate immune system. Nat. Rev. Immunol. 4: 512-520.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 512-520
    • Ulevitch, R.J.1
  • 9
    • 0024955886 scopus 로고
    • Approaching the asymptote? Evolution and revolution in immunology
    • Janeway, C.A., Jr. 1989. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb. Symp. Quant. Biol. 54 Pt 1: 1-13.
    • (1989) Cold Spring Harb. Symp. Quant. Biol. 54 Pt , vol.1 , pp. 1-13
    • Janeway Jr., C.A.1
  • 10
    • 0346731246 scopus 로고    scopus 로고
    • How we detect microbes and respond to them: the Toll-like receptors and their transducers
    • Beutler, B., K. Hoebe, X. Du, and R.J. Ulevitch. 2003. How we detect microbes and respond to them: the Toll-like receptors and their transducers. J. Leukoc. Biol. 74: 479-485.
    • (2003) J. Leukoc. Biol. , vol.74 , pp. 479-485
    • Beutler, B.1    Hoebe, K.2    Du, X.3    Ulevitch, R.J.4
  • 11
    • 0034886143 scopus 로고    scopus 로고
    • Toll-like receptors: critical proteins linking innate and acquired immunity
    • Akira, S., K. Takeda, and T. Kaisho. 2001. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat. Immunol. 2: 675-680.
    • (2001) Nat. Immunol. , vol.2 , pp. 675-680
    • Akira, S.1    Takeda, K.2    Kaisho, T.3
  • 12
    • 0035524488 scopus 로고    scopus 로고
    • Toll-like receptors and innate immunity
    • Medzhitov, R. 2001. Toll-like receptors and innate immunity. Nat. Rev. Immunol. 1: 135-145.
    • (2001) Nat. Rev. Immunol. , vol.1 , pp. 135-145
    • Medzhitov, R.1
  • 13
    • 0347135823 scopus 로고    scopus 로고
    • Therapeutic vaccination for chronic diseases: a new class of drugs in sight
    • Bachmann, M.F., and M.R. Dyer. 2004. Therapeutic vaccination for chronic diseases: a new class of drugs in sight. Nat. Rev. Drug Discov. 3: 81-88.
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 81-88
    • Bachmann, M.F.1    Dyer, M.R.2
  • 14
    • 0034898470 scopus 로고    scopus 로고
    • Conjugation of a selfantigen to papillomavirus-like particles allows for efficient induction of protective autoantibodies
    • Chackerian, B., D.R. Lowy, and J.T. Schiller. 2001. Conjugation of a selfantigen to papillomavirus-like particles allows for efficient induction of protective autoantibodies. J. Clin. Invest. 108: 415-423.
    • (2001) J. Clin. Invest. , vol.108 , pp. 415-423
    • Chackerian, B.1    Lowy, D.R.2    Schiller, J.T.3
  • 18
    • 0030595339 scopus 로고    scopus 로고
    • The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    • Lemaitre, B., E. Nicolas, L. Michaut, J.M. Reichhart, and J.A. Hoffmann. 1996. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86: 973-983.
    • (1996) Cell , vol.86 , pp. 973-983
    • Lemaitre, B.1    Nicolas, E.2    Michaut, L.3    Reichhart, J.M.4    Hoffmann, J.A.5
  • 20
    • 3242798925 scopus 로고    scopus 로고
    • Forward genetic dissection of afferent immunity: the role of TIR adapter proteins in innate and adaptive immune responses
    • Beutler, B., K. Hoebe, and L. Shamel. 2004. Forward genetic dissection of afferent immunity: the role of TIR adapter proteins in innate and adaptive immune responses. C.R. Biol. 327: 571-580.
    • (2004) C.R. Biol. , vol.327 , pp. 571-580
    • Beutler, B.1    Hoebe, K.2    Shamel, L.3
  • 21
    • 0036453721 scopus 로고    scopus 로고
    • Evolution of the TIR, tolls and TLRs: functional inferences from computational biology
    • Beutler, B., and M. Rehli. 2002. Evolution of the TIR, tolls and TLRs: functional inferences from computational biology. Curr. Top. Microbiol. Immunol. 270: 1-21.
    • (2002) Curr. Top. Microbiol. Immunol. , vol.270 , pp. 1-21
    • Beutler, B.1    Rehli, M.2
  • 22
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • Akira, S., and K. Takeda. 2004. Toll-like receptor signalling. Nat. Rev. Immunol. 4: 499-511.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 23
    • 3142654210 scopus 로고    scopus 로고
    • Inferences, questions and possibilities in Toll-like receptor signalling
    • Beutler, B. 2004. Inferences, questions and possibilities in Toll-like receptor signalling. Nature 430: 257-263.
    • (2004) Nature , vol.430 , pp. 257-263
    • Beutler, B.1
  • 25
    • 0033213590 scopus 로고    scopus 로고
    • Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components
    • Takeuchi, O., K. Hoshino, T. Kawai, H. Sanjo, H. Takada, T. Ogawa, K. Takeda, and S. Akira. 1999. Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components. Immunity 11: 443-451.
    • (1999) Immunity , vol.11 , pp. 443-451
    • Takeuchi, O.1    Hoshino, K.2    Kawai, T.3    Sanjo, H.4    Takada, H.5    Ogawa, T.6    Takeda, K.7    Akira, S.8
  • 27
    • 0038664380 scopus 로고    scopus 로고
    • The role of Toll-like receptor 2 in microbial disease and immunity
    • Wetzler, L.M. 2003. The role of Toll-like receptor 2 in microbial disease and immunity. Vaccine 21(Suppl 2): S55-60.
    • (2003) Vaccine , vol.21 , Issue.SUPPL. 2
    • Wetzler, L.M.1
  • 29
    • 0037439663 scopus 로고    scopus 로고
    • Lipopolysaccharides from Legionella and Rhizobium stimulate mouse bone marrow granulocytes via Toll-like receptor 2
    • Girard, R., T. Pedron, S. Uematsu, V. Balloy, M. Chignard, S. Akira, and R. Chaby. 2003. Lipopolysaccharides from Legionella and Rhizobium stimulate mouse bone marrow granulocytes via Toll-like receptor 2. J. Cell Sci. 116: 293-302.
    • (2003) J. Cell Sci. , vol.116 , pp. 293-302
    • Girard, R.1    Pedron, T.2    Uematsu, S.3    Balloy, V.4    Chignard, M.5    Akira, S.6    Chaby, R.7
  • 32
    • 0037083638 scopus 로고    scopus 로고
    • Cutting edge: Immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent
    • Massari, P., P. Henneke, Y. Ho, E. Latz, D.T. Golenbock, and L.M. Wetzler. 2002. Cutting edge: Immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent. J. Immunol. 168: 1533-1537.
    • (2002) J. Immunol. , vol.168 , pp. 1533-1537
    • Massari, P.1    Henneke, P.2    Ho, Y.3    Latz, E.4    Golenbock, D.T.5    Wetzler, L.M.6
  • 35
    • 0037290876 scopus 로고    scopus 로고
    • Mammalian Toll-like receptors
    • Akira, S. 2003. Mammalian Toll-like receptors. Curr. Opin. Immunol. 15: 5-11.
    • (2003) Curr. Opin. Immunol. , vol.15 , pp. 5-11
    • Akira, S.1
  • 36
    • 0032716031 scopus 로고    scopus 로고
    • The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for Toll-like receptors
    • Means, T.K., E. Lien, A. Yoshimura, S. Wang, D.T. Golenbock, and M.J. Fenton. 1999. The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for Toll-like receptors. J. Immunol. 163: 6748-6755.
    • (1999) J. Immunol. , vol.163 , pp. 6748-6755
    • Means, T.K.1    Lien, E.2    Yoshimura, A.3    Wang, S.4    Golenbock, D.T.5    Fenton, M.J.6
  • 39
    • 0033945681 scopus 로고    scopus 로고
    • Enteroaggregative Escherichia coli expresses a novel flagellin that causes IL-8 release from intestinal epithelial cells
    • Steiner, T.S., J.P. Nataro, C.E. Poteet-Smith, J.A. Smith, and R.L. Guerrant. 2000. Enteroaggregative Escherichia coli expresses a novel flagellin that causes IL-8 release from intestinal epithelial cells. J. Clin. Invest. 105: 1769-1777.
    • (2000) J. Clin. Invest. , vol.105 , pp. 1769-1777
    • Steiner, T.S.1    Nataro, J.P.2    Poteet-Smith, C.E.3    Smith, J.A.4    Guerrant, R.L.5
  • 40
    • 0035863730 scopus 로고    scopus 로고
    • Flagellin, a novel mediator of Salmonellainduced epithelial activation and systemic inflammation: I kappa B alpha degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunction
    • Eaves-Pyles, T., K. Murthy, L. Liaudet, L. Virag, G. Ross, F.G. Soriano, C. Szabo, and A.L. Salzman. 2001. Flagellin, a novel mediator of Salmonellainduced epithelial activation and systemic inflammation: I kappa B alpha degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunction. J. Immunol. 166: 1248-1260.
    • (2001) J. Immunol. , vol.166 , pp. 1248-1260
    • Eaves-Pyles, T.1    Murthy, K.2    Liaudet, L.3    Virag, L.4    Ross, G.5    Soriano, F.G.6    Szabo, C.7    Salzman, A.L.8
  • 45
    • 0021256125 scopus 로고
    • Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity
    • Tokunaga, T., H. Yamamoto, S. Shimada, H. Abe, T. Fukuda, Y. Fujisawa, Y. Furutani, O. Yano, T. Kataoka, and T. Sudo. 1984. Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity. J. Natl. Cancer Inst. 72: 955-962.
    • (1984) J. Natl. Cancer Inst. , vol.72 , pp. 955-962
    • Tokunaga, T.1    Yamamoto, H.2    Shimada, S.3    Abe, H.4    Fukuda, T.5    Fujisawa, Y.6    Furutani, Y.7    Yano, O.8    Kataoka, T.9    Sudo, T.10
  • 47
    • 0034044735 scopus 로고    scopus 로고
    • The function of type I interferons in antimicrobial immunity
    • Bogdan, C. 2000. The function of type I interferons in antimicrobial immunity. Curr. Opin. Immunol. 12: 419-424.
    • (2000) Curr. Opin. Immunol. , vol.12 , pp. 419-424
    • Bogdan, C.1
  • 48
    • 0036467492 scopus 로고    scopus 로고
    • The interferon-alpha/beta system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors
    • Taniguchi, T., and A. Takaoka. 2002. The interferon-alpha/beta system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors. Curr. Opin. Immunol. 14: 111-116.
    • (2002) Curr. Opin. Immunol. , vol.14 , pp. 111-116
    • Taniguchi, T.1    Takaoka, A.2
  • 50
    • 0035909372 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    • Alexopoulou, L., A.C. Holt, R. Medzhitov, and R.A. Flavell. 2001. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413: 732-738.
    • (2001) Nature , vol.413 , pp. 732-738
    • Alexopoulou, L.1    Holt, A.C.2    Medzhitov, R.3    Flavell, R.A.4
  • 52
    • 1542317550 scopus 로고    scopus 로고
    • Innate antiviral responses by means of TLR7-mediated recognition of singlestranded RNA
    • Diebold, S.S., T. Kaisho, H. Hemmi, S. Akira, and C. Reise Sousa. 2004. Innate antiviral responses by means of TLR7-mediated recognition of singlestranded RNA. Science 303: 1529-1531.
    • (2004) Science , vol.303 , pp. 1529-1531
    • Diebold, S.S.1    Kaisho, T.2    Hemmi, H.3    Akira, S.4    Reise Sousa, C.5
  • 53
    • 0036219195 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA and their immune effects
    • Krieg, A.M. 2002. CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 20: 709-760.
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 709-760
    • Krieg, A.M.1
  • 57
    • 5444262511 scopus 로고    scopus 로고
    • Toll-like receptor control of the adaptive immune responses
    • Iwasaki, A., and R. Medzhitov. 2004. Toll-like receptor control of the adaptive immune responses. Nat. Immunol. 5: 987-995.
    • (2004) Nat. Immunol. , vol.5 , pp. 987-995
    • Iwasaki, A.1    Medzhitov, R.2
  • 58
    • 0031423761 scopus 로고    scopus 로고
    • MyD88: an adapter that recruits IRAK to the IL-1 receptor complex
    • Wesche, H., W.J. Henzel, W. Shillinglaw, S. Li, and Z. Cao. 1997. MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity 7: 837-847.
    • (1997) Immunity , vol.7 , pp. 837-847
    • Wesche, H.1    Henzel, W.J.2    Shillinglaw, W.3    Li, S.4    Cao, Z.5
  • 59
    • 0030694108 scopus 로고    scopus 로고
    • IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
    • Muzio, M., J. Ni, P. Feng, and V.M. Dixit. 1997. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 278: 1612-1615.
    • (1997) Science , vol.278 , pp. 1612-1615
    • Muzio, M.1    Ni, J.2    Feng, P.3    Dixit, V.M.4
  • 62
    • 0033634977 scopus 로고    scopus 로고
    • TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway
    • Takaesu, G., S. Kishida, A. Hiyama, K. Yamaguchi, H. Shibuya, K. Irie, J. Ninomiya-Tsuji, and K. Matsumoto. 2000. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol Cell 5: 649-658.
    • (2000) Mol Cell , vol.5 , pp. 649-658
    • Takaesu, G.1    Kishida, S.2    Hiyama, A.3    Yamaguchi, K.4    Shibuya, H.5    Irie, K.6    Ninomiya-Tsuji, J.7    Matsumoto, K.8
  • 63
    • 0037153130 scopus 로고    scopus 로고
    • The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors
    • Horng, T., G.M. Barton, R.A. Flavell, and R. Medzhitov. 2002. The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature 420: 329-333.
    • (2002) Nature , vol.420 , pp. 329-333
    • Horng, T.1    Barton, G.M.2    Flavell, R.A.3    Medzhitov, R.4
  • 65
    • 0033166472 scopus 로고    scopus 로고
    • Unresponsiveness of MyD88-deficient mice to endotoxin
    • Kawai, T., O. Adachi, T. Ogawa, K. Takeda, and S. Akira. 1999. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11: 115-122.
    • (1999) Immunity , vol.11 , pp. 115-122
    • Kawai, T.1    Adachi, O.2    Ogawa, T.3    Takeda, K.4    Akira, S.5
  • 66
    • 0035889228 scopus 로고    scopus 로고
    • Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide- inducible genes
    • Kawai, T., O. Takeuchi, T. Fujita, J. Inoue, P.F. Muhlradt, S. Sato, K. Hoshino, and S. Akira. 2001. Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide- inducible genes. J. Immunol. 167: 5887-5894.
    • (2001) J. Immunol. , vol.167 , pp. 5887-5894
    • Kawai, T.1    Takeuchi, O.2    Fujita, T.3    Inoue, J.4    Muhlradt, P.F.5    Sato, S.6    Hoshino, K.7    Akira, S.8
  • 67
    • 0032481352 scopus 로고    scopus 로고
    • Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300
    • Yoneyama, M., W. Suhara, Y. Fukuhara, M. Fukuda, E. Nishida, and T. Fujita. 1998. Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300. EMBO J. 17: 1087-1095.
    • (1998) EMBO J. , vol.17 , pp. 1087-1095
    • Yoneyama, M.1    Suhara, W.2    Fukuhara, Y.3    Fukuda, M.4    Nishida, E.5    Fujita, T.6
  • 68
    • 0037114185 scopus 로고    scopus 로고
    • Cutting edge: a novel Toll/ IL-1 receptor domain-containing adapter that preferentially activates the IFNbeta promoter in the Toll-like receptor signaling
    • Yamamoto, M., S. Sato, K. Mori, K. Hoshino, O. Takeuchi, K. Takeda, and S. Akira. 2002. Cutting edge: a novel Toll/ IL-1 receptor domain-containing adapter that preferentially activates the IFNbeta promoter in the Toll-like receptor signaling. J. Immunol. 169: 6668-6672.
    • (2002) J. Immunol. , vol.169 , pp. 6668-6672
    • Yamamoto, M.1    Sato, S.2    Mori, K.3    Hoshino, K.4    Takeuchi, O.5    Takeda, K.6    Akira, S.7
  • 71
    • 0042591216 scopus 로고    scopus 로고
    • TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling
    • Bin, L.H., L.G. Xu, and H.B. Shu. 2003. TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. J. Biol. Chem. 278: 24526-24532.
    • (2003) J. Biol. Chem. , vol.278 , pp. 24526-24532
    • Bin, L.H.1    Xu, L.G.2    Shu, H.B.3
  • 72
    • 0345991221 scopus 로고    scopus 로고
    • TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta
    • Oshiumi, H., M. Sasai, K. Shida, T. Fujita, M. Matsumoto, and T. Seya. 2003. TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta. J. Biol. Chem. 278: 49751-49762.
    • (2003) J. Biol. Chem. , vol.278 , pp. 49751-49762
    • Oshiumi, H.1    Sasai, M.2    Shida, K.3    Fujita, T.4    Matsumoto, M.5    Seya, T.6
  • 74
    • 0242643726 scopus 로고    scopus 로고
    • Detection of peptidoglycans by NOD proteins
    • Royet, J., and J.M. Reichhart. 2003. Detection of peptidoglycans by NOD proteins. Trends Cell Biol. 13: 610-614.
    • (2003) Trends Cell Biol. , vol.13 , pp. 610-614
    • Royet, J.1    Reichhart, J.M.2
  • 78
    • 0038624558 scopus 로고    scopus 로고
    • NODs: intracellular proteins involved in inflammation and apoptosis
    • Inohara, N., and G. Nunez. 2003. NODs: intracellular proteins involved in inflammation and apoptosis. Nat. Rev. Immunol. 3: 371-382.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 371-382
    • Inohara, N.1    Nunez, G.2
  • 79
    • 2542457495 scopus 로고    scopus 로고
    • Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases
    • Martinon, F., and J. Tschopp. 2004. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 117: 561-574.
    • (2004) Cell , vol.117 , pp. 561-574
    • Martinon, F.1    Tschopp, J.2
  • 80
    • 0345303939 scopus 로고    scopus 로고
    • Lessons from Nod2 studies: towards a link between Crohn's disease and bacterial sensing
    • Girardin, S.E., J.P. Hugot, and P.J. Sansonetti. 2003. Lessons from Nod2 studies: towards a link between Crohn's disease and bacterial sensing. Trends Immunol. 24: 652-658.
    • (2003) Trends Immunol. , vol.24 , pp. 652-658
    • Girardin, S.E.1    Hugot, J.P.2    Sansonetti, P.J.3
  • 81
    • 0034767753 scopus 로고    scopus 로고
    • Antiviral actions of interferons
    • table of contents
    • Samuel, C.E. 2001. Antiviral actions of interferons. Clin. Microbiol. Rev. 14: 778-809, table of contents.
    • (2001) Clin. Microbiol. Rev. , vol.14 , pp. 778-809
    • Samuel, C.E.1
  • 82
    • 0037711199 scopus 로고    scopus 로고
    • The dsRNA binding protein family: critical roles, diverse cellular functions
    • Saunders, L.R., and G.N. Barber. 2003. The dsRNA binding protein family: critical roles, diverse cellular functions. FASEB J. 17: 961-983.
    • (2003) FASEB J. , vol.17 , pp. 961-983
    • Saunders, L.R.1    Barber, G.N.2
  • 84
  • 86
    • 0033580949 scopus 로고    scopus 로고
    • Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2
    • Schwandner, R., R. Dziarski, H. Wesche, M. Rothe, and C.J. Kirschning. 1999. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J. Biol. Chem. 274: 17406-17409.
    • (1999) J. Biol. Chem. , vol.274 , pp. 17406-17409
    • Schwandner, R.1    Dziarski, R.2    Wesche, H.3    Rothe, M.4    Kirschning, C.J.5
  • 88
    • 0033592748 scopus 로고    scopus 로고
    • The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
    • Underhill, D.M., A. Ozinsky, A.M. Hajjar, A. Stevens, C.B. Wilson, M. Bassetti, and A. Aderem. 1999. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature 401: 811-815.
    • (1999) Nature , vol.401 , pp. 811-815
    • Underhill, D.M.1    Ozinsky, A.2    Hajjar, A.M.3    Stevens, A.4    Wilson, C.B.5    Bassetti, M.6    Aderem, A.7
  • 91
    • 0026464967 scopus 로고
    • DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth
    • Yamamoto, S., T. Yamamoto, S. Shimada, E. Kuramoto, O. Yano, T. Kataoka, and T. Tokunaga. 1992. DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth. Microbiol. Immunol. 36: 983-997.
    • (1992) Microbiol. Immunol. , vol.36 , pp. 983-997
    • Yamamoto, S.1    Yamamoto, T.2    Shimada, S.3    Kuramoto, E.4    Yano, O.5    Kataoka, T.6    Tokunaga, T.7
  • 92
    • 0030613651 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity
    • Chu, R. S., O. S. Targoni, A. M. Krieg, P. V. Lehmann, and C. V. Harding. 1997. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J. Exp. Med. 186: 1623-1629.
    • (1997) J. Exp. Med. , vol.186 , pp. 1623-1629
    • Chu, R.S.1    Targoni, O.S.2    Krieg, A.M.3    Lehmann, P.V.4    Harding, C.V.5
  • 94
    • 0038717560 scopus 로고    scopus 로고
    • CpG motifs: the active ingredient in bacterial extracts?
    • Krieg, A.M. 2003. CpG motifs: the active ingredient in bacterial extracts? Nat. Med. 9: 831-835.
    • (2003) , vol.9 , pp. 831-835
    • Krieg, A.M.1
  • 95
    • 0037726802 scopus 로고    scopus 로고
    • OM-174, a new adjuvant with a potential for human use, induces a protective response when administered with the synthetic C-terminal fragment 242-310 from the circumsporozoite protein of Plasmodium berghei
    • Meraldi, V., R. Audran, J.F. Romero, V. Brossard, J. Bauer, J.A. Lopez, and G. Corradin. 2003. OM-174, a new adjuvant with a potential for human use, induces a protective response when administered with the synthetic C-terminal fragment 242-310 from the circumsporozoite protein of Plasmodium berghei. Vaccine 21: 2485-2491.
    • (2003) Vaccine , vol.21 , pp. 2485-2491
    • Meraldi, V.1    Audran, R.2    Romero, J.F.3    Brossard, V.4    Bauer, J.5    Lopez, J.A.6    Corradin, G.7
  • 98
    • 0142058176 scopus 로고    scopus 로고
    • Recent advances in the discovery and delivery of vaccine adjuvants
    • O'Hagan, D.T., and N.M. Valiante. 2003. Recent advances in the discovery and delivery of vaccine adjuvants. Nat. Rev. Drug Discov. 2: 727-735.
    • (2003) Nat. Rev. Drug Discov. , vol.2 , pp. 727-735
    • O'Hagan, D.T.1    Valiante, N.M.2
  • 99
    • 0035885126 scopus 로고    scopus 로고
    • Sterically stabilized cationic liposomes improve the uptake and immunostimulatory activity of CpG oligonucleotides
    • Gursel, I., M. Gursel, K.J. Ishii, and D.M. Klinman. 2001. Sterically stabilized cationic liposomes improve the uptake and immunostimulatory activity of CpG oligonucleotides. J. Immunol. 167: 3324-3328.
    • (2001) J. Immunol. , vol.167 , pp. 3324-3328
    • Gursel, I.1    Gursel, M.2    Ishii, K.J.3    Klinman, D.M.4
  • 100
    • 1642566566 scopus 로고    scopus 로고
    • Nonmethylated CG motifs packaged into virus-like particles induce protective cytotoxic Tcell responses in the absence of systemic side effects
    • Storni, T., C. Ruedl, K. Schwarz, R.A. Schwendener, W.A. Renner, and M.F. Bachmann. 2004. Nonmethylated CG motifs packaged into virus-like particles induce protective cytotoxic Tcell responses in the absence of systemic side effects. J. Immunol. 172: 1777-1785.
    • (2004) J. Immunol. , vol.172 , pp. 1777-1785
    • Storni, T.1    Ruedl, C.2    Schwarz, K.3    Schwendener, R.A.4    Renner, W.A.5    Bachmann, M.F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.