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1
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0023890664
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Molecular organization and function of the complement system
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Muller-Eberhard HJ. Molecular organization and function of the complement system. Annu Rev Biochem. 57:1988;321-347.
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(1988)
Annu Rev Biochem
, vol.57
, pp. 321-347
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Muller-Eberhard, H.J.1
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2
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0028958669
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The CD19/CD21/TAPA-1 complex of B lymphocytes: Linking natural to acquired immunity
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of outstanding interest. Outstanding review of historical evidence demonstrating complement enhancement of humoral immunity and more specifically the role of CD21/CD19 in B cell signal transduction.
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Fearon DT, Carter RH. The CD19/CD21/TAPA-1 complex of B lymphocytes: linking natural to acquired immunity. of outstanding interest Annu Rev Immunol. 13:1995;127-149 Outstanding review of historical evidence demonstrating complement enhancement of humoral immunity and more specifically the role of CD21/CD19 in B cell signal transduction.
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(1995)
Annu Rev Immunol
, vol.13
, pp. 127-149
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Fearon, D.T.1
Carter, R.H.2
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3
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0019231842
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The follicular dendritic cell: Its role in antigen presentation in the generation of immunological memory
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Klaus GGB, Humphrey JH, Kunkl A, Dongworth DW. The follicular dendritic cell: its role in antigen presentation in the generation of immunological memory. Immunol Rev. 53:1980;359.
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(1980)
Immunol Rev
, vol.53
, pp. 359
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Klaus, G.G.B.1
Humphrey, J.H.2
Kunkl, A.3
Dongworth, D.W.4
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4
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0030593030
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C3d of complement as a molecular adjuvant: Bridging innate and acquired immunity
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of outstanding interest. Provides the first direct evidence that attachment of C3d results in significant enhancement of humoral response and the enhancement is mediated by the C3d receptor, CD21.
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Dempsey PW, Allison MED, Akkaraju S, Goodnow CC, Fearon DT. C3d of complement as a molecular adjuvant: bridging innate and acquired immunity. of outstanding interest Science. 271:1996;348-350 Provides the first direct evidence that attachment of C3d results in significant enhancement of humoral response and the enhancement is mediated by the C3d receptor, CD21.
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(1996)
Science
, vol.271
, pp. 348-350
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Dempsey, P.W.1
Allison, M.E.D.2
Akkaraju, S.3
Goodnow, C.C.4
Fearon, D.T.5
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5
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85177148402
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Natural antibody and complement-mediated antigen processing and presentation by B lymphocytes
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Important finding that soluble protein antigens incubated in fresh human serum can activate complement and that this increases the efficiency of antigen uptake by B cells.
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Thornton BP, Vetvicka V, Ross GD. Natural antibody and complement-mediated antigen processing and presentation by B lymphocytes. J Immunol. 152:1995;1527-1532 Important finding that soluble protein antigens incubated in fresh human serum can activate complement and that this increases the efficiency of antigen uptake by B cells.
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(1995)
J Immunol
, vol.152
, pp. 1527-1532
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Thornton, B.P.1
Vetvicka, V.2
Ross, G.D.3
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6
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0028134642
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C3b covalently associated to tetanus toxin modulates TT processing and presentation by U937 cells
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Rey-Millet CA, Villiers CL, Gabert FM, Chesne S, Colomb MG. C3b covalently associated to tetanus toxin modulates TT processing and presentation by U937 cells. Mol Immunol. 31:1994;1321-1327.
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(1994)
Mol Immunol
, vol.31
, pp. 1321-1327
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Rey-Millet, C.A.1
Villiers, C.L.2
Gabert, F.M.3
Chesne, S.4
Colomb, M.G.5
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7
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0028275823
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Covalent binding of C3b to monoclonal antibodies selectively up-regulates heavy chain recognition by T cells
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Santoro L, Drouet C, Reboul A, Mach JP, Colomb MG. Covalent binding of C3b to monoclonal antibodies selectively up-regulates heavy chain recognition by T cells. Eur J Immunol. 24:1994;1620-1626.
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(1994)
Eur J Immunol
, vol.24
, pp. 1620-1626
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Santoro, L.1
Drouet, C.2
Reboul, A.3
Mach, J.P.4
Colomb, M.G.5
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8
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0028898379
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Modulation of antigen processing and presentation by covalently linked complement C3b fragment
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of special interest. First biochemical evidence that coupling C3b to antigen alters its degradation by the APC.
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Jacquier M, Gabert F, Villiers M, Colomb M. Modulation of antigen processing and presentation by covalently linked complement C3b fragment. of special interest Immunology. 84:1995;164-170 First biochemical evidence that coupling C3b to antigen alters its degradation by the APC.
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(1995)
Immunology
, vol.84
, pp. 164-170
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Jacquier, M.1
Gabert, F.2
Villiers, M.3
Colomb, M.4
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9
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0021345152
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Local opsonization by secreted macrophage complement components. Role of receptors for complement in uptake of zymosan
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Ezekowitz RA, Sim RB, Hill M, Gordon S. Local opsonization by secreted macrophage complement components. Role of receptors for complement in uptake of zymosan. J Exp Med. 159:1983;244-260.
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(1983)
J Exp Med
, vol.159
, pp. 244-260
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Ezekowitz, R.A.1
Sim, R.B.2
Hill, M.3
Gordon, S.4
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10
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0029997797
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IFN-gamma up-regulates expression of complement components C3 and C4 by stabilization of mRNA
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Mitchell TJ, Naughton M, Norsworthy P, Davies KA, Walport MJ, Morley BJ. IFN-gamma up-regulates expression of complement components C3 and C4 by stabilization of mRNA. J Immunol. 156:1996;4429-4434.
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(1996)
J Immunol
, vol.156
, pp. 4429-4434
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Mitchell, T.J.1
Naughton, M.2
Norsworthy, P.3
Davies, K.A.4
Walport, M.J.5
Morley, B.J.6
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11
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0027209277
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Differential expression of complement C3 and C4 in the human kidney
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Welch TR, Beischel LS, Witte DP. Differential expression of complement C3 and C4 in the human kidney. J Clin Invest. 92:1993;1451-1458.
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(1993)
J Clin Invest
, vol.92
, pp. 1451-1458
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Welch, T.R.1
Beischel, L.S.2
Witte, D.P.3
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12
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0030183099
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Interleukin-1a enhances the biosynthesis of complement C3 and Factor B by human kidney proximal tubular epithelial cells in vitro
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Gerritsma JSJ, Gerritsen AF, Van Kooten C, Van Es LA, Daha MR. Interleukin-1a enhances the biosynthesis of complement C3 and Factor B by human kidney proximal tubular epithelial cells in vitro. Mol Immunol. 33:1996;847-854.
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(1996)
Mol Immunol
, vol.33
, pp. 847-854
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Gerritsma, J.S.J.1
Gerritsen, A.F.2
Van Kooten, C.3
Van Es, L.A.4
Daha, M.R.5
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13
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0028969347
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Transcriptional regulation of complement genes
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Volanakis JE. Transcriptional regulation of complement genes. Annu Rev Immunol. 13:1995;277-305.
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(1995)
Annu Rev Immunol
, vol.13
, pp. 277-305
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Volanakis, J.E.1
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14
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0026559947
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Cis- And trans-acting elements required for constitutive and cytokine-regulated expression of mouse complement C3 gene
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Kawamura N, Singer L, Wetsel RA, Colten HR. Cis- and trans-acting elements required for constitutive and cytokine-regulated expression of mouse complement C3 gene. Biochem J. 283:1992;705-712.
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(1992)
Biochem J
, vol.283
, pp. 705-712
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Kawamura, N.1
Singer, L.2
Wetsel, R.A.3
Colten, H.R.4
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15
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0028790714
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Follicular dentritic cells, interdigitating cells, and cells of the monocyte-macrophage lineage are the C1q-producing sources in the spleen
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of special interest. Important finding that C1q, the first component of complement, is made locally within the lymphoid compartment.
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Schwaeble W, Schaefer MKH, Petry F, Fink T, Knebel D, Weihe E, Loos M. Follicular dentritic cells, interdigitating cells, and cells of the monocyte-macrophage lineage are the C1q-producing sources in the spleen. of special interest J Immunol. 155:1995;4971-4978 Important finding that C1q, the first component of complement, is made locally within the lymphoid compartment.
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(1995)
J Immunol
, vol.155
, pp. 4971-4978
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Schwaeble, W.1
Schaefer, M.K.H.2
Petry, F.3
Fink, T.4
Knebel, D.5
Weihe, E.6
Loos, M.7
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16
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8944232100
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Regulation of the B cell response to T-dependent antigens by classical pathway complement
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of special interest. Demonstrates that the defect in the humoral response to soluble T-cell-dependent antigen in C3 and C4 deficient animals is not due to priming of T cells but lies at the level of the B cell and a failure to form a normal number and size of germinal centers.
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Fischer MB, Ma M, Goerg S, Zhou X, Xia J, Finco O, Han S, Kelsoe G, Howard RG, Rothstein TL, Kremmer E, Rosen FS, Carroll MC. Regulation of the B cell response to T-dependent antigens by classical pathway complement. of special interest J Immunol. 157:1996;549-556 Demonstrates that the defect in the humoral response to soluble T-cell-dependent antigen in C3 and C4 deficient animals is not due to priming of T cells but lies at the level of the B cell and a failure to form a normal number and size of germinal centers.
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(1996)
J Immunol
, vol.157
, pp. 549-556
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Fischer, M.B.1
Ma, M.2
Goerg, S.3
Zhou, X.4
Xia, J.5
Finco, O.6
Han, S.7
Kelsoe, G.8
Howard, R.G.9
Rothstein, T.L.10
Kremmer, E.11
Rosen, F.S.12
Carroll, M.C.13
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17
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0029007836
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Antibodies to murine complement receptor 1 and 2 can inhibit the antibody response in vivo without inhibiting T helper cell induction
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of special interest. Important finding that T cell priming is normal following pretreatment of mice with monoclonal antibody against CD21 despite the lack of a humoral immune response.
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Gustavsson S, Kinoshita T, Heyman B. Antibodies to murine complement receptor 1 and 2 can inhibit the antibody response in vivo without inhibiting T helper cell induction. of special interest J Immunol. 154:1995;6524-6528 Important finding that T cell priming is normal following pretreatment of mice with monoclonal antibody against CD21 despite the lack of a humoral immune response.
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(1995)
J Immunol
, vol.154
, pp. 6524-6528
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Gustavsson, S.1
Kinoshita, T.2
Heyman, B.3
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18
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15844412034
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Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen
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Demonstrates for the first time a definitive requirement for expression of CD21 on the B cell in order for a normal humoral response to soluble T-cell-dependent antigen to occur. The study also demonstrates a role for both CD21 and CD35 in the maintenance of peritoneal B-1 cells and for the maintenance of normal serum levels of the switched isotypes of lgG.
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Ahearn JM, Fischer MB, Croix D, Goerg S, Ma M, Xia J, Zhou X, Rothstein TL, Carroll MC. Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen. Immunity. 4:1996;251-264 Demonstrates for the first time a definitive requirement for expression of CD21 on the B cell in order for a normal humoral response to soluble T-cell-dependent antigen to occur. The study also demonstrates a role for both CD21 and CD35 in the maintenance of peritoneal B-1 cells and for the maintenance of normal serum levels of the switched isotypes of lgG.
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(1996)
Immunity
, vol.4
, pp. 251-264
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Ahearn, J.M.1
Fischer, M.B.2
Croix, D.3
Goerg, S.4
Ma, M.5
Xia, J.6
Zhou, X.7
Rothstein, T.L.8
Carroll, M.C.9
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19
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0029926153
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Markedly impaired humoral immune response in mice deficient in complement receptor 1 and 2
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of outstanding interest. Demonstrates a requirement for CD21 in the formation of a secondary humoral response to a particulate T-dependent antigen (SRBC) and that the impaired humoral response was characterized by a reduction in the number of GCs.
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Molina H, Holers VM, Li B, Fung Y, Mariathasan S, Goeller J, Strauss-Schoenberger J, Karr R, Chaplin D. Markedly impaired humoral immune response in mice deficient in complement receptor 1 and 2. of outstanding interest Proc Natl Acad Sci USA. 93:1996;3357-3361 Demonstrates a requirement for CD21 in the formation of a secondary humoral response to a particulate T-dependent antigen (SRBC) and that the impaired humoral response was characterized by a reduction in the number of GCs.
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(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 3357-3361
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Molina, H.1
Holers, V.M.2
Li, B.3
Fung, Y.4
Mariathasan, S.5
Goeller, J.6
Strauss-Schoenberger, J.7
Karr, R.8
Chaplin, D.9
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20
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0029916530
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Antibody response to a T-dependent antigen requires B cell expression of complement receptors
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of outstanding interest. Demonstrates that CD21 expression on FDC in absence of B cell expression is not sufficient for a secondary response.
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Croix DA, Ahearn JM, Rosengard AM, Han S, Kelsoe G, Ma M, Carroll MC. Antibody response to a T-dependent antigen requires B cell expression of complement receptors. of outstanding interest J Exp Med. 183:1996;18571-18864 Demonstrates that CD21 expression on FDC in absence of B cell expression is not sufficient for a secondary response.
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(1996)
J Exp Med
, vol.183
, pp. 18571-18864
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Croix, D.A.1
Ahearn, J.M.2
Rosengard, A.M.3
Han, S.4
Kelsoe, G.5
Ma, M.6
Carroll, M.C.7
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21
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0029094609
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Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule
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of special interest. Important observation demonstrating the role of CD19 in the humoral response to T-dependent antigens and in the maintenance of peritoneal B-1 cells.
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Engel P, Zhou L, Ord DC, Sato S, Koller B, Tedder TF. Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. of special interest Immunity. 3:1995;39-50 Important observation demonstrating the role of CD19 in the humoral response to T-dependent antigens and in the maintenance of peritoneal B-1 cells.
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(1995)
Immunity
, vol.3
, pp. 39-50
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Engel, P.1
Zhou, L.2
Ord, D.C.3
Sato, S.4
Koller, B.5
Tedder, T.F.6
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22
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0029064680
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Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice
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of special interest. Important observation demonstrating the role of CD19 in the humoral response to T-dependent antigens and in the maintenance of peritoneal B-1 cells.
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Rickert RC, Rajewsky K, Roes J. Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. of special interest Nature. 376:1995;352-355 Important observation demonstrating the role of CD19 in the humoral response to T-dependent antigens and in the maintenance of peritoneal B-1 cells.
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(1995)
Nature
, vol.376
, pp. 352-355
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Rickert, R.C.1
Rajewsky, K.2
Roes, J.3
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23
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0028807328
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In situ studies of the germinal center reaction
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Kelsoe G. In situ studies of the germinal center reaction. Adv Immunol. 60:1995;267-288.
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(1995)
Adv Immunol
, vol.60
, pp. 267-288
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Kelsoe, G.1
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