메뉴 건너뛰기




Volumn 19, Issue 34, 2013, Pages 6186-6206

Manipulation and engineering of metabolic and biosynthetic pathway of plant polyphenols

Author keywords

Anthocyanins; Biosynthesis; Flavonoids; Metabolic engineering; Tannins

Indexed keywords

ANTHOCYANIN; CHALCONE DERIVATIVE; FLAVONE DERIVATIVE; FLAVONOID; FLAVONOL; ISOFLAVONE DERIVATIVE; ISOFLAVONOID; POLYPHENOL; STILBENE DERIVATIVE; TANNIN;

EID: 84887912573     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612811319340011     Document Type: Review
Times cited : (27)

References (178)
  • 1
    • 36549032015 scopus 로고    scopus 로고
    • The evolution of flavonoids and their genes
    • Springer: Ohio, USA, In: Grotewold E, ed
    • Rausher MD. The evolution of flavonoids and their genes. In: Grotewold E, ed., The Science of Flavonoids. Springer: Ohio, USA 2006; pp. 175-212.
    • (2006) The Science of Flavonoids , pp. 175-212
    • Rausher, M.D.1
  • 2
    • 26444611245 scopus 로고    scopus 로고
    • Flavones and flavone synthases
    • Martens S, Mithöfer A. Flavones and flavone synthases. Phytochemistry 2005; 66: 2399-407.
    • (2005) Phytochemistry , vol.66 , pp. 2399-2407
    • Martens, S.1    Mithöfer, A.2
  • 3
    • 0034979805 scopus 로고    scopus 로고
    • Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology
    • Winkel-Shirley B. Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology. Plant Physiol 2001; 126: 485-93.
    • (2001) Plant Physiol , vol.126 , pp. 485-493
    • Winkel-Shirley, B.1
  • 4
    • 0036011081 scopus 로고    scopus 로고
    • Biosynthesis of flavonoids and effects of stress
    • Winkel-Shirley B. Biosynthesis of flavonoids and effects of stress. Curr Opinion Plant Biol 2002; 5: 218-23.
    • (2002) Curr Opinion Plant Biol , vol.5 , pp. 218-223
    • Winkel-Shirley, B.1
  • 5
    • 36549012724 scopus 로고    scopus 로고
    • Evolution and current status of research in phenolic compounds
    • Boudet A-M. Evolution and current status of research in phenolic compounds. Phytochemistry 2007; 68: 2722-35.
    • (2007) Phytochemistry , vol.68 , pp. 2722-2735
    • Boudet, A.-M.1
  • 7
    • 0035076924 scopus 로고    scopus 로고
    • Bioflavonoids classification, pharmacological, biochemical effects and therapeutic potential
    • Raj NK, Sripal RM, Chaluvadi MR, Krishna DR. Bioflavonoids classification, pharmacological, biochemical effects and therapeutic potential. Indian J Pharmacol 2001; 33: 2-16.
    • (2001) Indian J Pharmacol , vol.33 , pp. 2-16
    • Raj, N.K.1    Sripal, R.M.2    Chaluvadi, M.R.3    Krishna, D.R.4
  • 12
    • 0035033774 scopus 로고    scopus 로고
    • Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and ATPase activities by interaction with dietary flavonoids
    • Leslie EM, Mao Q, Oleschuk CJ, Deeley RG, Cole SPC. Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and ATPase activities by interaction with dietary flavonoids. Mol Pharmacol 2001; 59: 1171-80.
    • (2001) Mol Pharmacol , vol.59 , pp. 1171-1180
    • Leslie, E.M.1    Mao, Q.2    Oleschuk, C.J.3    Deeley, R.G.4    Cole, S.P.C.5
  • 13
    • 2142711101 scopus 로고    scopus 로고
    • Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport
    • Zhang S, Yang X, Morris ME. Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport. Mol Pharmacol 2004; 65: 1208-16.
    • (2004) Mol Pharmacol , vol.65 , pp. 1208-1216
    • Zhang, S.1    Yang, X.2    Morris, M.E.3
  • 14
    • 25444524567 scopus 로고    scopus 로고
    • Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5)
    • Wu C-P, Calcagno AM, Hladky SB, Ambudkar SV, Barrand MA. Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5). FEBS Journal 2005; 272: 4725-40.
    • (2005) FEBS Journal , vol.272 , pp. 4725-4740
    • Wu, C.-P.1    Calcagno, A.M.2    Hladky, S.B.3    Ambudkar, S.V.4    Barrand, M.A.5
  • 15
    • 33644914487 scopus 로고    scopus 로고
    • Flavonoid-drug interactions: Effects of flavonoids on ABC transporters
    • Morris ME, Zhang S. Flavonoid-drug interactions: Effects of flavonoids on ABC transporters. Life Sci 2006; 78: 2116-30.
    • (2006) Life Sci , vol.78 , pp. 2116-2130
    • Morris, M.E.1    Zhang, S.2
  • 16
    • 33749444911 scopus 로고    scopus 로고
    • The potential of flavonoids to influence drug metabolism and pharmacokinetics by local gastrointestinal mechanisms
    • Cermak R, Wolffram S. The potential of flavonoids to influence drug metabolism and pharmacokinetics by local gastrointestinal mechanisms. Curr Drug Metab 2006; 7: 729-44.
    • (2006) Curr Drug Metab , vol.7 , pp. 729-744
    • Cermak, R.1    Wolffram, S.2
  • 17
    • 33750353446 scopus 로고    scopus 로고
    • Flavonoid-mediated inhibition of intestinal ABC transporters may affect the oral bioavailability of drugs, food-borne toxic compounds and bioactive ingredients
    • Brand W, Schutte ME, Williamson G, et al. Flavonoid-mediated inhibition of intestinal ABC transporters may affect the oral bioavailability of drugs, food-borne toxic compounds and bioactive ingredients. Biomed Pharmacotherapy 2006; 60: 508-19.
    • (2006) Biomed Pharmacotherapy , vol.60 , pp. 508-519
    • Brand, W.1    Schutte, M.E.2    Williamson, G.3
  • 18
    • 13844281685 scopus 로고    scopus 로고
    • Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
    • Manach C, Williamson G, Morand C, Scalbert A, Rémésy C. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clinical Nutrition 2005; 81: 230S-42S.
    • (2005) Am J Clinical Nutrition , vol.81
    • Manach, C.1    Williamson, G.2    Morand, C.3    Scalbert, A.4    Rémésy, C.5
  • 19
    • 38949207932 scopus 로고    scopus 로고
    • Metabolic transformation has a profound effect on anti-inflammatory activity of flavonoids such as quercetin: Lack of association between antioxidant and lipoxygenase inhibitory activity
    • Loke WM, Proudfoot JM, Stewart S, et al. Metabolic transformation has a profound effect on anti-inflammatory activity of flavonoids such as quercetin: Lack of association between antioxidant and lipoxygenase inhibitory activity. Biochem Pharmacol 2008; 75: 1045-53.
    • (2008) Biochem Pharmacol , vol.75 , pp. 1045-1053
    • Loke, W.M.1    Proudfoot, J.M.2    Stewart, S.3
  • 20
    • 33646390855 scopus 로고    scopus 로고
    • Absorption and metabolism of caffeic acid and chlorogenic acid in the small intestine of rats
    • Lafay S, Morand C, Manach C, Besson C, Scalbert A. Absorption and metabolism of caffeic acid and chlorogenic acid in the small intestine of rats. Br J Nutrition 2006; 96: 39-46.
    • (2006) Br J Nutrition , vol.96 , pp. 39-46
    • Lafay, S.1    Morand, C.2    Manach, C.3    Besson, C.4    Scalbert, A.5
  • 21
    • 32444451694 scopus 로고    scopus 로고
    • Bioavailability is improved by enzymatic modification of the citrus flavonoid hesperidin in humans: A randomized, double-blind, crossover trial
    • Nielsen ILF, Chee WSS, Poulsen L, et al. Bioavailability is improved by enzymatic modification of the citrus flavonoid hesperidin in humans: A randomized, double-blind, crossover trial. J Nutrition 2006; 136: 404-8.
    • (2006) J Nutrition , vol.136 , pp. 404-408
    • Nielsen, I.L.F.1    Chee, W.S.S.2    Poulsen, L.3
  • 22
    • 0001735423 scopus 로고    scopus 로고
    • Metabolic Engineering to Modify Flower Color
    • Tanaka Y, Tsuda S, Kusumi T. Metabolic Engineering to Modify Flower Color. Plant Cell Physiol 1998; 39: 1119-26.
    • (1998) Plant Cell Physiol , vol.39 , pp. 1119-1126
    • Tanaka, Y.1    Tsuda, S.2    Kusumi, T.3
  • 23
    • 0036914809 scopus 로고    scopus 로고
    • cDNA cloning, heterologous expressions, and functional characterization of malonyl-Coenzyme A: Anthocyanidin 3-O-glucoside-6"-Omalonyltransferase from Dahlia flowers
    • Suzuki H, Nakayama T, Yonekura-Sakakibara K, et al. cDNA cloning, heterologous expressions, and functional characterization of malonyl-Coenzyme A: Anthocyanidin 3-O-glucoside-6"-Omalonyltransferase from Dahlia flowers. Plant Physiol 2002; 130: 2142-51.
    • (2002) Plant Physiol , vol.130 , pp. 2142-2151
    • Suzuki, H.1    Nakayama, T.2    Yonekura-Sakakibara, K.3
  • 24
    • 0000137303 scopus 로고
    • An anti-sense chalcone synthase gene in transgenic plants inhibits flower pigmentation
    • van der Krol AR, Lenting PE, Veenstra J, et al. An anti-sense chalcone synthase gene in transgenic plants inhibits flower pigmentation. Nature 1988; 333: 866-9.
    • (1988) Nature , vol.333 , pp. 866-869
    • van der Krol, A.R.1    Lenting, P.E.2    Veenstra, J.3
  • 25
    • 0028300359 scopus 로고
    • Modification of flower color in florist's chrysanthemum: Production of a whiteflowering variety through molecular genetics
    • Courtney-Gutterson N, Napoli C, Lemieux C, et al. Modification of flower color in florist's chrysanthemum: production of a whiteflowering variety through molecular genetics. Biotechnology (N Y) 1994; 12: 268-71.
    • (1994) Biotechnology (N Y) , vol.12 , pp. 268-271
    • Courtney-Gutterson, N.1    Napoli, C.2    Lemieux, C.3
  • 26
    • 0031980993 scopus 로고    scopus 로고
    • An antisense chalcone synthase cDNA leads to novel colour patterns in lisianthus (Eustoma grandiflorum) flowers
    • Deroles S, Bradley JM, Schwinn K, et al. An antisense chalcone synthase cDNA leads to novel colour patterns in lisianthus (Eustoma grandiflorum) flowers. Mol Breeding 1998; 4: 59-66.
    • (1998) Mol Breeding , vol.4 , pp. 59-66
    • Deroles, S.1    Bradley, J.M.2    Schwinn, K.3
  • 27
    • 0031929267 scopus 로고    scopus 로고
    • Production of yellow colour in flowers: Redirection of flavonoid biosynthesis in Petunia
    • Davies KM, Bloor SJ, Spiller GB, Deroles SC. Production of yellow colour in flowers: redirection of flavonoid biosynthesis in Petunia. Plant J 1998; 13: 259-66.
    • (1998) Plant J , vol.13 , pp. 259-266
    • Davies, K.M.1    Bloor, S.J.2    Spiller, G.B.3    Deroles, S.C.4
  • 29
    • 0034646691 scopus 로고    scopus 로고
    • Modification of flower color in torenia (Torenia fournieri Lind.) by genetic transformation
    • Aida R, Kishimoto S, Tanaka Y, Shibata M. Modification of flower color in torenia (Torenia fournieri Lind.) by genetic transformation. Plant Sci 2000; 153: 33-42.
    • (2000) Plant Sci , vol.153 , pp. 33-42
    • Aida, R.1    Kishimoto, S.2    Tanaka, Y.3    Shibata, M.4
  • 30
    • 0036314962 scopus 로고    scopus 로고
    • Modification of flower color and fragrance by antisense suppression of the flavanone 3-hydroxylase gene
    • Zuker A, Tzfira T, Ben-Meir H, et al. Modification of flower color and fragrance by antisense suppression of the flavanone 3-hydroxylase gene. Molecular Breeding 2002; 9: 33-41.
    • (2002) Molecular Breeding , vol.9 , pp. 33-41
    • Zuker, A.1    Tzfira, T.2    Ben-Meir, H.3
  • 31
    • 0037403591 scopus 로고    scopus 로고
    • A rationale for the shift in colour towards blue in transgenic carnation flowers expressing the flavonoid 3, 5-hydroxylase gene
    • Fukui Y, Tanaka Y, Kusumi T, Iwashita T, Nomoto K. A rationale for the shift in colour towards blue in transgenic carnation flowers expressing the flavonoid 3, 5-hydroxylase gene. Phytochemistry 2003; 63: 15-23.
    • (2003) Phytochemistry , vol.63 , pp. 15-23
    • Fukui, Y.1    Tanaka, Y.2    Kusumi, T.3    Iwashita, T.4    Nomoto, K.5
  • 32
    • 0031721802 scopus 로고    scopus 로고
    • Polyphenols: Chemistry, dietary sources, metabolism, and nutritional significance
    • Bravo L. Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutr Rev 1998; 56: 317-33.
    • (1998) Nutr Rev , vol.56 , pp. 317-333
    • Bravo, L.1
  • 34
    • 84984082768 scopus 로고
    • Tannins-their occurrence and significance
    • White T. Tannins-their occurrence and significance. J Sci Food Agriculture 1957; 8: 377-85.
    • (1957) J Sci Food Agriculture , vol.8 , pp. 377-385
    • White, T.1
  • 36
    • 0030515619 scopus 로고    scopus 로고
    • Natural polyphenols (vegetable tannins) as drugs: Possible modes of action
    • Haslam E. Natural polyphenols (vegetable tannins) as drugs: Possible modes of action. J Natural Products 1996; 59: 205-15.
    • (1996) J Natural Products , vol.59 , pp. 205-215
    • Haslam, E.1
  • 39
    • 34948864395 scopus 로고    scopus 로고
    • Dietary polyphenols and their biological significance
    • Han X, Shen T, Lou H. Dietary polyphenols and their biological significance. International J Mol Sci 2007; 8: 950-88.
    • (2007) International J Mol Sci , vol.8 , pp. 950-988
    • Han, X.1    Shen, T.2    Lou, H.3
  • 41
    • 84869808716 scopus 로고    scopus 로고
    • The shikimate pathway and aromatic amino acid biosynthesis in plants
    • Maeda H, Dudareva N. The shikimate pathway and aromatic amino acid biosynthesis in plants. Annu Rev Plant Biol 2012; 63: 73-105.
    • (2012) Annu Rev Plant Biol , vol.63 , pp. 73-105
    • Maeda, H.1    Dudareva, N.2
  • 42
    • 76549093442 scopus 로고    scopus 로고
    • Phenylpropanoid biosynthesis
    • Vogt T. Phenylpropanoid biosynthesis. Molecular Plant 2010; 3: 2-20.
    • (2010) Molecular Plant , vol.3 , pp. 2-20
    • Vogt, T.1
  • 43
    • 77957024399 scopus 로고    scopus 로고
    • Chapter four comparative genomics of the shikimate pathway in Arabidopsis, Populus trichocarpa and Oryza sativa: Shikimate pathway gene family structure and identification of candidates for missing links in phenylalanine biosynthesis
    • Elsevier, In: John TR, ed
    • Hamberger B, Ehlting J, Barbazuk B, Douglas CJ. Chapter four comparative genomics of the shikimate pathway in Arabidopsis, Populus trichocarpa and Oryza sativa: Shikimate pathway gene family structure and identification of candidates for missing links in phenylalanine biosynthesis. In: John TR, ed., Recent Advances in Phytochemistry. Elsevier 2006; pp. 85-113.
    • (2006) Recent Advances in Phytochemistry , pp. 85-113
    • Hamberger, B.1    Ehlting, J.2    Barbazuk, B.3    Douglas, C.J.4
  • 44
    • 0037321888 scopus 로고    scopus 로고
    • The biosynthesis of shikimate metabolites
    • Knaggs AR. The biosynthesis of shikimate metabolites. Nat Prod Rep 2003; 20: 119-36.
    • (2003) Nat Prod Rep , vol.20 , pp. 119-136
    • Knaggs, A.R.1
  • 45
  • 46
    • 85056430639 scopus 로고    scopus 로고
    • Molecular biology and biotechnology of flavonoid biosynthesis
    • CRC Press LLC: Boca Raton, In: Andersen ØM, Markham KR, eds
    • Davies KM, Schwinn KE. Molecular biology and biotechnology of flavonoid biosynthesis. In: Andersen ØM, Markham KR, eds., Flavonoids: chemistry, biochemistry and applications. CRC Press LLC: Boca Raton 2006; pp. 143-219.
    • (2006) Flavonoids: Chemistry, biochemistry and applications , pp. 143-219
    • Davies, K.M.1    Schwinn, K.E.2
  • 47
    • 57749088682 scopus 로고    scopus 로고
    • Tomato phenylalanine ammonia-lyase gene family, highly redundant but strongly underutilized
    • Chang A, Lim MH, Lee SW, Robb EJ, Nazar RN. Tomato phenylalanine ammonia-lyase gene family, highly redundant but strongly underutilized. J Biol Chem 2008; 283: 33591-601.
    • (2008) J Biol Chem , vol.283 , pp. 33591-33601
    • Chang, A.1    Lim, M.H.2    Lee, S.W.3    Robb, E.J.4    Nazar, R.N.5
  • 49
    • 75349100110 scopus 로고    scopus 로고
    • Structural features and biological properties of ellagitannins in some plant families of the order Myrtales
    • Yoshida T, Amakura Y, Yoshimura M. Structural features and biological properties of ellagitannins in some plant families of the order Myrtales. Int J Mol Sci 2010; 11: 79-106.
    • (2010) Int J Mol Sci , vol.11 , pp. 79-106
    • Yoshida, T.1    Amakura, Y.2    Yoshimura, M.3
  • 50
    • 0035800127 scopus 로고    scopus 로고
    • Biosynthesis and subcellular distribution of hydrolyzable tannins
    • Grundhöfer P, Niemetz R, Schilling G, Gross GG. Biosynthesis and subcellular distribution of hydrolyzable tannins. Phytochemistry 2001; 57: 915-27.
    • (2001) Phytochemistry , vol.57 , pp. 915-927
    • Grundhöfer, P.1    Niemetz, R.2    Schilling, G.3    Gross, G.G.4
  • 51
    • 0037235027 scopus 로고    scopus 로고
    • Gallic acid and hydrolysable tannins are formed in birch leaves from an intermediate compound of the shikimate pathway
    • Ossipov V, Salminen J-P, Ossipova S, Haukioja E, Pihlaja K. Gallic acid and hydrolysable tannins are formed in birch leaves from an intermediate compound of the shikimate pathway. Biochem Systematics Ecol 2003; 31: 3-16.
    • (2003) Biochem Systematics Ecol , vol.31 , pp. 3-16
    • Ossipov, V.1    Salminen, J.-P.2    Ossipova, S.3    Haukioja, E.4    Pihlaja, K.5
  • 52
    • 36549060628 scopus 로고    scopus 로고
    • Vegetable tannins-Lessons of a phytochemical lifetime
    • Haslam E. Vegetable tannins-Lessons of a phytochemical lifetime. Phytochemistry 2007; 68: 2713-21.
    • (2007) Phytochemistry , vol.68 , pp. 2713-2721
    • Haslam, E.1
  • 53
    • 0003806626 scopus 로고
    • Biosynthesis of gallotannins. Enzymatic conversion of 1, 6-digalloylglucose to 1, 2, 6-trigalloylglucose
    • Denzel K, Schilling G, Gross G. Biosynthesis of gallotannins. Enzymatic conversion of 1, 6-digalloylglucose to 1, 2, 6-trigalloylglucose. Planta 1988; 176: 135-7.
    • (1988) Planta , vol.176 , pp. 135-137
    • Denzel, K.1    Schilling, G.2    Gross, G.3
  • 54
    • 0024971189 scopus 로고
    • Biosynthesis of gallotannins: β-Glucogallin-dependent formation of 1, 2, 3, 4, 6-pentagalloylglucose by enzymatic galloylation of 1, 2, 3, 6-tetragalloylglucose
    • Cammann J, Denzel K, Schilling G, Gross GG. Biosynthesis of gallotannins: β-Glucogallin-dependent formation of 1, 2, 3, 4, 6-pentagalloylglucose by enzymatic galloylation of 1, 2, 3, 6-tetragalloylglucose. Archives Biochem Biophysics 1989; 273: 58-63.
    • (1989) Archives Biochem Biophysics , vol.273 , pp. 58-63
    • Cammann, J.1    Denzel, K.2    Schilling, G.3    Gross, G.G.4
  • 55
    • 0001253287 scopus 로고
    • Biosynthesis of 1, 2, 3, 6-tetra-O-galloyl-β-dglucose
    • Hagenah S, Gross GG. Biosynthesis of 1, 2, 3, 6-tetra-O-galloyl-β-dglucose. Phytochemistry 1993; 32: 637-41.
    • (1993) Phytochemistry , vol.32 , pp. 637-641
    • Hagenah, S.1    Gross, G.G.2
  • 56
    • 23444432854 scopus 로고    scopus 로고
    • Enzymology of gallotannin and ellagitannin biosynthesis
    • Niemetz R, Gross GG. Enzymology of gallotannin and ellagitannin biosynthesis. Phytochemistry 2005; 66: 2001-11.
    • (2005) Phytochemistry , vol.66 , pp. 2001-2011
    • Niemetz, R.1    Gross, G.G.2
  • 57
    • 0344874161 scopus 로고    scopus 로고
    • Ellagitannin biosynthesis: Laccase-catalyzed dimerization of tellimagrandin II to cornusiin E in Tellima grandiflora
    • Niemetz R, Gross GG. Ellagitannin biosynthesis: laccase-catalyzed dimerization of tellimagrandin II to cornusiin E in Tellima grandiflora. Phytochemistry 2003; 64: 1197-201.
    • (2003) Phytochemistry , vol.64 , pp. 1197-1201
    • Niemetz, R.1    Gross, G.G.2
  • 58
    • 0037310568 scopus 로고    scopus 로고
    • Oxidation of pentagalloylglucose to the ellagitannin, tellimagrandin II, by a phenol oxidase from Tellima grandiflora leaves
    • Niemetz R, Gross GG. Oxidation of pentagalloylglucose to the ellagitannin, tellimagrandin II, by a phenol oxidase from Tellima grandiflora leaves. Phytochemistry 2003; 62: 301-6.
    • (2003) Phytochemistry , vol.62 , pp. 301-306
    • Niemetz, R.1    Gross, G.G.2
  • 60
    • 23744450065 scopus 로고    scopus 로고
    • Biological functionality of ellagic acid: A review
    • Vattem DA, Shetty K. Biological functionality of ellagic acid: A review. J Food Biochem 2005; 29: 234-66.
    • (2005) J Food Biochem , vol.29 , pp. 234-266
    • Vattem, D.A.1    Shetty, K.2
  • 61
    • 0037014296 scopus 로고    scopus 로고
    • Ellagic acid and ellagitannins affect on sedimentation in muscadine juice and wine
    • Lee J-H, Talcott ST. Ellagic acid and ellagitannins affect on sedimentation in muscadine juice and wine. J Agricultural Food Chem 2002; 50: 3971-6.
    • (2002) J Agricultural Food Chem , vol.50 , pp. 3971-3976
    • Lee, J.-H.1    Talcott, S.T.2
  • 62
    • 79959685028 scopus 로고    scopus 로고
    • Effects of grape (Vitis labrusca B.) peel and seed extracts on phenolics, antioxidants and anthocyanins in grape juice
    • Ghafoor K, Al-Juhaimi F, Choi YH. Effects of grape (Vitis labrusca B.) peel and seed extracts on phenolics, antioxidants and anthocyanins in grape juice. Pak J Bot 2011; 43: 1581-6.
    • (2011) Pak J Bot , vol.43 , pp. 1581-1586
    • Ghafoor, K.1    Al-Juhaimi, F.2    Choi, Y.H.3
  • 63
    • 1542289813 scopus 로고    scopus 로고
    • Fruit maturity and juice extraction influences ellagic acid derivatives and other antioxidant polyphenolics in muscadine grapes
    • Lee J-H, Talcott ST. Fruit maturity and juice extraction influences ellagic acid derivatives and other antioxidant polyphenolics in muscadine grapes. J Agricultural Food Chem 2003; 52: 361-6.
    • (2003) J Agricultural Food Chem , vol.52 , pp. 361-366
    • Lee, J.-H.1    Talcott, S.T.2
  • 64
    • 51649111023 scopus 로고    scopus 로고
    • Grapes and human health: A perspective
    • Pezzuto JM. Grapes and human health: A perspective. J Agricultural Food Chem 2008; 56: 6777-84.
    • (2008) J Agricultural Food Chem , vol.56 , pp. 6777-6784
    • Pezzuto, J.M.1
  • 65
    • 0000661347 scopus 로고    scopus 로고
    • Determination of stilbenes (trans-astringin, cis-and trans-piceid, and cis-and trans-resveratrol) in Portuguese wines
    • Ribeiro de Lima MT, Waffo-Téguo P, Teissedre PL, et al. Determination of stilbenes (trans-astringin, cis-and trans-piceid, and cis-and trans-resveratrol) in Portuguese wines. J Agricultural Food Chem 1999; 47: 2666-70.
    • (1999) J Agricultural Food Chem , vol.47 , pp. 2666-2670
    • Ribeiro de Lima, M.T.1    Waffo-Téguo, P.2    Teissedre, P.L.3
  • 66
    • 33645226101 scopus 로고    scopus 로고
    • Stilbenes: Quantitative extraction from grape skins, contribution of grape solids to wine and variation during wine maturation
    • Sun B, Ribes AM, Leandro MC, Belchior AP, Spranger MI. Stilbenes: Quantitative extraction from grape skins, contribution of grape solids to wine and variation during wine maturation. Analytica Chimica Acta 2006; 563: 382-90.
    • (2006) Analytica Chimica Acta , vol.563 , pp. 382-390
    • Sun, B.1    Ribes, A.M.2    Leandro, M.C.3    Belchior, A.P.4    Spranger, M.I.5
  • 67
    • 0345529031 scopus 로고    scopus 로고
    • Modeling the coantioxidant behavior of monofunctional phenols. Applications to some relevant compounds
    • Amorati R, Ferroni F, Pedulli GF, Valgimigli L. Modeling the coantioxidant behavior of monofunctional phenols. Applications to some relevant compounds. J Organic Chem 2003; 68: 9654-8.
    • (2003) J Organic Chem , vol.68 , pp. 9654-9658
    • Amorati, R.1    Ferroni, F.2    Pedulli, G.F.3    Valgimigli, L.4
  • 68
    • 67449103065 scopus 로고    scopus 로고
    • Metabolism and roles of stilbenes in plants
    • Chong J, Poutaraud A, Hugueney P. Metabolism and roles of stilbenes in plants. Plant Sci 2009; 177: 143-55.
    • (2009) Plant Sci , vol.177 , pp. 143-155
    • Chong, J.1    Poutaraud, A.2    Hugueney, P.3
  • 69
    • 78651502974 scopus 로고    scopus 로고
    • Biosynthesis, metabolism, molecular engineering, and biological functions of stilbene phytoalexins in plants
    • Jeandet P, Delaunois B, Conreux A, et al. Biosynthesis, metabolism, molecular engineering, and biological functions of stilbene phytoalexins in plants. BioFactors 2010; 36: 331-341.
    • (2010) BioFactors , vol.36 , pp. 331-341
    • Jeandet, P.1    Delaunois, B.2    Conreux, A.3
  • 70
    • 80053614230 scopus 로고    scopus 로고
    • Biosynthesis of the major tetrahydroxystilbenes in spruce, astringin and isorhapontin, proceeds via resveratrol and Is enhanced by fungal Infection
    • Hammerbacher A, Ralph SG, Bohlmann J, Fenning TM, Gershenzon J, Schmidt A. Biosynthesis of the major tetrahydroxystilbenes in spruce, astringin and isorhapontin, proceeds via resveratrol and Is enhanced by fungal Infection. Plant Physiol 2011; 157: 876-90.
    • (2011) Plant Physiol , vol.157 , pp. 876-890
    • Hammerbacher, A.1    Ralph, S.G.2    Bohlmann, J.3    Fenning, T.M.4    Gershenzon, J.5    Schmidt, A.6
  • 71
    • 0028321623 scopus 로고
    • Evidence that stilbene synthases have developed from chalcone synthases several times in the course of evolution
    • Tropf S, Lanz T, Rensing SA, Schröder J, Schröder G. Evidence that stilbene synthases have developed from chalcone synthases several times in the course of evolution. J Molecular Evolution 1994; 38: 610-8.
    • (1994) J Molecular Evolution , vol.38 , pp. 610-618
    • Tropf, S.1    Lanz, T.2    Rensing, S.A.3    Schröder, J.4    Schröder, G.5
  • 72
    • 78650657557 scopus 로고    scopus 로고
    • Biosynthesis of anthocyanins and their regulation in colored grapes
    • He F, Mu L, Yan GL, et al. Biosynthesis of anthocyanins and their regulation in colored grapes. Molecules 2010; 15: 9057-91.
    • (2010) Molecules , vol.15 , pp. 9057-9091
    • He, F.1    Mu, L.2    Yan, G.L.3
  • 73
    • 84964987110 scopus 로고    scopus 로고
    • Chalcones, dihydrochalcones, and aurones
    • CRC Press LLC: Boca Raton, In: Andersen ØM, Markham KR, eds
    • Veitch NC, Grayer RJ. Chalcones, dihydrochalcones, and aurones. In: Andersen ØM, Markham KR, eds., Flavonoids: chemistry, biochemistry and applications. CRC Press LLC: Boca Raton 2006; pp. 1003-101.
    • (2006) Flavonoids: Chemistry, biochemistry and applications , pp. 1003-1101
    • Veitch, N.C.1    Grayer, R.J.2
  • 74
    • 0345687480 scopus 로고    scopus 로고
    • Aurones: A subclass of flavones with promising biological potential
    • Boumendjel A. Aurones: A subclass of flavones with promising biological potential. Curr Med Chem 2003; 10: 2621-30.
    • (2003) Curr Med Chem , vol.10 , pp. 2621-2630
    • Boumendjel, A.1
  • 75
    • 24044525249 scopus 로고    scopus 로고
    • Structural elucidation of chalcone reductase and implications for deoxychalcone biosynthesis
    • Bomati EK, Austin MB, Bowman ME, Dixon RA, Noel JP. Structural elucidation of chalcone reductase and implications for deoxychalcone biosynthesis. J Biological Chem 2005; 280: 30496-503.
    • (2005) J Biological Chem , vol.280 , pp. 30496-30503
    • Bomati, E.K.1    Austin, M.B.2    Bowman, M.E.3    Dixon, R.A.4    Noel, J.P.5
  • 76
    • 57749110574 scopus 로고    scopus 로고
    • Biosynthesis of phloridzin in apple (Malus domestica Borkh.)
    • Gosch C, Halbwirth H, Kuhn J, Miosic S, Stich K. Biosynthesis of phloridzin in apple (Malus domestica Borkh.). Plant Science 2009; 176: 223-31.
    • (2009) Plant Science , vol.176 , pp. 223-231
    • Gosch, C.1    Halbwirth, H.2    Kuhn, J.3    Miosic, S.4    Stich, K.5
  • 77
    • 0035875799 scopus 로고    scopus 로고
    • Specificity analysis and mechanism of aurone synthesis catalyzed by aureusidin synthase, a polyphenol oxidase homolog responsible for flower coloration
    • Nakayama T, Sato T, Fukui Y, et al. Specificity analysis and mechanism of aurone synthesis catalyzed by aureusidin synthase, a polyphenol oxidase homolog responsible for flower coloration. FEBS Letters 2001; 499: 107-11.
    • (2001) FEBS Letters , vol.499 , pp. 107-111
    • Nakayama, T.1    Sato, T.2    Fukui, Y.3
  • 78
    • 85056397280 scopus 로고    scopus 로고
    • Flavones and dihydroflavonols
    • CRC Press LLC: Boca Raton, In: Andersen ØM, Markham KR, eds
    • Grayer RJ, Veitch NC. Flavones and dihydroflavonols. In: Andersen ØM, Markham KR, eds., Flavonoids: chemistry, biochemistry and applications. CRC Press LLC: Boca Raton 2006; pp. 917-1002.
    • (2006) Flavonoids: Chemistry, biochemistry and applications , pp. 917-1002
    • Grayer, R.J.1    Veitch, N.C.2
  • 79
    • 67650685038 scopus 로고    scopus 로고
    • Biosynthesis and biotechnological production of flavanones: Current state and perspectives
    • Fowler Z, Koffas MG. Biosynthesis and biotechnological production of flavanones: current state and perspectives. Applied Microbiol Biotechnol 2009; 83: 799-808.
    • (2009) Applied Microbiol Biotechnol , vol.83 , pp. 799-808
    • Fowler, Z.1    Koffas, M.G.2
  • 80
    • 84887930903 scopus 로고    scopus 로고
    • Production of anthocyanins in grape cell cultures: A potential source of raw material for pharmaceutical, food, and cosmetic industries
    • In: Sladonja B, Poljuha D, eds. InTech: Croatia
    • Ananaga A, Georgiev V, Ochieng J, Phills B, Tsolova V. Production of anthocyanins in grape cell cultures: A potential source of raw material for pharmaceutical, food, and cosmetic industries. In: Sladonja B, Poljuha D, eds., The Mediterranean Genetic Code-Grapevine and Olive. InTech: Croatia 2012.
    • (2012) The Mediterranean Genetic Code-Grapevine and Olive
    • Ananaga, A.1    Georgiev, V.2    Ochieng, J.3    Phills, B.4    Tsolova, V.5
  • 81
    • 84920093428 scopus 로고    scopus 로고
    • The biosynthesis of flavonoids
    • Springer: Ohio, USA, In: Grotewold E, ed
    • Winkel BSJ. The biosynthesis of flavonoids. In: Grotewold E, ed., The Science of Flavonoids. Springer: Ohio, USA 2006; pp. 71-96.
    • (2006) The Science of Flavonoids , pp. 71-96
    • Winkel, B.S.J.1
  • 82
    • 84886951115 scopus 로고    scopus 로고
    • Flavonoids: Chemistry, biochemistry and antioxidant activity
    • Alzand KI, Mohamed MA. Flavonoids: Chemistry, biochemistry and antioxidant activity. J Pharm Res 2012; 5: 4013-2.
    • (2012) J Pharm Res , vol.5 , pp. 4013-4022
    • Alzand, K.I.1    Mohamed, M.A.2
  • 83
    • 33846916619 scopus 로고    scopus 로고
    • Flavonoid pigments as tools in molecular genetics
    • Springer: Ohio, USA, In: Grotewold E, ed
    • Chopra S, Hoshino A, Boddu J, Iida S. Flavonoid pigments as tools in molecular genetics. In: Grotewold E, ed., The Science of Flavonoids. Springer: Ohio, USA 2006; pp. 147-74.
    • (2006) The Science of Flavonoids , pp. 147-174
    • Chopra, S.1    Hoshino, A.2    Boddu, J.3    Iida, S.4
  • 86
    • 0035542775 scopus 로고    scopus 로고
    • Elicitor-induced association of isoflavone Omethyltransferase with endomembranes prevents the formation and 7-O-methylation of daidzein during isoflavonoid phytoalexin biosynthesis
    • Liu CJ, Dixon RA. Elicitor-induced association of isoflavone Omethyltransferase with endomembranes prevents the formation and 7-O-methylation of daidzein during isoflavonoid phytoalexin biosynthesis. Plant Cell 2001; 13: 2643-58.
    • (2001) Plant Cell , vol.13 , pp. 2643-2658
    • Liu, C.J.1    Dixon, R.A.2
  • 87
    • 18144363888 scopus 로고    scopus 로고
    • Molecular and biochemical characterization of 2-hydroxyisoflavanone dehydratase. Involvement of carboxylesterase-like proteins in Leguminous isoflavone biosynthesis
    • Akashi T, Aoki T, Ayabe SI. Molecular and biochemical characterization of 2-hydroxyisoflavanone dehydratase. Involvement of carboxylesterase-like proteins in Leguminous isoflavone biosynthesis. Plant Physiol 2005; 137: 882-91.
    • (2005) Plant Physiol , vol.137 , pp. 882-891
    • Akashi, T.1    Aoki, T.2    Ayabe, S.I.3
  • 88
    • 33749336654 scopus 로고    scopus 로고
    • Identification of cDNAs encoding pterocarpan reductase involved in isoflavan phytoalexin biosynthesis in Lotus japonicus by EST mining
    • Akashi T, Koshimizu S, Aoki T, Ayabe SI. Identification of cDNAs encoding pterocarpan reductase involved in isoflavan phytoalexin biosynthesis in Lotus japonicus by EST mining. FEBS Letters 2006; 580: 5666-70.
    • (2006) FEBS Letters , vol.580 , pp. 5666-5670
    • Akashi, T.1    Koshimizu, S.2    Aoki, T.3    Ayabe, S.I.4
  • 89
    • 79953052392 scopus 로고    scopus 로고
    • A genomic approach to isoflavone biosynthesis in kudzu (Pueraria lobata)
    • He X, Blount J, Ge S, Tang Y, Dixon R. A genomic approach to isoflavone biosynthesis in kudzu (Pueraria lobata). Planta 2011; 233: 843-55.
    • (2011) Planta , vol.233 , pp. 843-855
    • He, X.1    Blount, J.2    Ge, S.3    Tang, Y.4    Dixon, R.5
  • 90
    • 0037449585 scopus 로고    scopus 로고
    • Role of anthocyanidin reductase, encoded by BANYULS in plant flavonoid biosynthesis
    • Xie DY, Sharma SB, Paiva NL, Ferreira D, Dixon RA. Role of anthocyanidin reductase, encoded by BANYULS in plant flavonoid biosynthesis. Science 2003; 299: 396-9.
    • (2003) Science , vol.299 , pp. 396-399
    • Xie, D.Y.1    Sharma, S.B.2    Paiva, N.L.3    Ferreira, D.4    Dixon, R.A.5
  • 91
    • 0346059448 scopus 로고    scopus 로고
    • Anthocyanidin reductases from Medicago truncatula and Arabidopsis thaliana
    • Xie D-Y, Sharma SB, Dixon RA. Anthocyanidin reductases from Medicago truncatula and Arabidopsis thaliana. Archives Biochem Biophys 2004; 422: 91-102.
    • (2004) Archives Biochem Biophys , vol.422 , pp. 91-102
    • Xie, D.-Y.1    Sharma, S.B.2    Dixon, R.A.3
  • 93
    • 84889299642 scopus 로고    scopus 로고
    • Recent advances in the field of anthocyanins-main focus on structures
    • eds, In: Daayf F., Lattanzio V, Wiley-Blackwell
    • Andersen ØM. Recent advances in the field of anthocyanins-main focus on structures. In: Daayf F., Lattanzio V. eds., Recent advances in polyphenol research. Wiley-Blackwell 2009; pp. 167-201.
    • (2009) Recent advances in polyphenol research , pp. 167-201
    • Andersen, Ø.M.1
  • 94
    • 20444468508 scopus 로고    scopus 로고
    • Plant biochemistry: Anthocyanin biosynthesis in roses
    • Ogata J, Kanno Y, Itoh Y, Tsugawa H, Suzuki M. Plant biochemistry: Anthocyanin biosynthesis in roses. Nature 2005; 435: 757-8.
    • (2005) Nature , vol.435 , pp. 757-758
    • Ogata, J.1    Kanno, Y.2    Itoh, Y.3    Tsugawa, H.4    Suzuki, M.5
  • 95
    • 0025895183 scopus 로고
    • Toward a science of metabolic engineering
    • Bailey JE. Toward a science of metabolic engineering. Science (New York, N. Y.) 1991; 252: 1668-75.
    • (1991) Science (New York, N.Y.) , vol.252 , pp. 1668-1675
    • Bailey, J.E.1
  • 97
    • 18044387854 scopus 로고    scopus 로고
    • Metabolomics, genomics, proteomics, and the identification of enzymes and their substrates and products
    • Fridman E, Pichersky E. Metabolomics, genomics, proteomics, and the identification of enzymes and their substrates and products. Curr Opinion Plant Biol 2005; 8: 242-8.
    • (2005) Curr Opinion Plant Biol , vol.8 , pp. 242-248
    • Fridman, E.1    Pichersky, E.2
  • 98
    • 18044372085 scopus 로고    scopus 로고
    • Engineering of plant natural product pathways
    • Dixon RA. Engineering of plant natural product pathways. Curr Opinion Plant Biol 2005; 8: 329-36.
    • (2005) Curr Opinion Plant Biol , vol.8 , pp. 329-336
    • Dixon, R.A.1
  • 99
    • 0030715289 scopus 로고    scopus 로고
    • Transgenic plant technology is entering the era of metabolic engineering
    • Dixon RA, Arntzen CJ. Transgenic plant technology is entering the era of metabolic engineering. Trends Biotechnol 1997; 15: 441-4.
    • (1997) Trends Biotechnol , vol.15 , pp. 441-444
    • Dixon, R.A.1    Arntzen, C.J.2
  • 100
    • 0033119845 scopus 로고    scopus 로고
    • Plant metabolic engineering: Are we ready for phase two?: Editorial overview
    • Ohlrogge J. Plant metabolic engineering: are we ready for phase two?: Editorial overview. Curr Opinion Plant Biol 1999; 2: 121-2.
    • (1999) Curr Opinion Plant Biol , vol.2 , pp. 121-122
    • Ohlrogge, J.1
  • 101
    • 0035146432 scopus 로고    scopus 로고
    • Plant metabolic engineering
    • DellaPenna D. Plant metabolic engineering. Plant Physiol 2001; 125: 160-3.
    • (2001) Plant Physiol , vol.125 , pp. 160-163
    • DellaPenna, D.1
  • 102
    • 0035979211 scopus 로고    scopus 로고
    • Progress in plant metabolic engineering
    • Broun P, Somerville C. Progress in plant metabolic engineering. Proc Natl Acad Sci 2001; 98: 8925-7.
    • (2001) Proc Natl Acad Sci , vol.98 , pp. 8925-8927
    • Broun, P.1    Somerville, C.2
  • 103
    • 1842714379 scopus 로고    scopus 로고
    • Progress in plant metabolic engineering
    • Capell T, Christou P. Progress in plant metabolic engineering. Curr Opinion Biotechnol 2004; 15: 148-54.
    • (2004) Curr Opinion Biotechnol , vol.15 , pp. 148-154
    • Capell, T.1    Christou, P.2
  • 104
    • 33845307207 scopus 로고    scopus 로고
    • Review: Genetically modified plants for the promotion of human health
    • Sakakibara K, Saito K. Review: genetically modified plants for the promotion of human health. Biotechnol Letters 2006; 28: 1983-91.
    • (2006) Biotechnol Letters , vol.28 , pp. 1983-1991
    • Sakakibara, K.1    Saito, K.2
  • 105
    • 0036272795 scopus 로고    scopus 로고
    • Genetic, molecular, and genomic approaches to improve the value of plant foods and feeds
    • Galili G, Galili S, Lewinsohn E, Tadmor Y. Genetic, molecular, and genomic approaches to improve the value of plant foods and feeds. Critical Rev Plant Sci 2002; 21: 167-204.
    • (2002) Critical Rev Plant Sci , vol.21 , pp. 167-204
    • Galili, G.1    Galili, S.2    Lewinsohn, E.3    Tadmor, Y.4
  • 106
    • 0035212386 scopus 로고    scopus 로고
    • Medical molecular farming: Production of antibodies, biopharmaceuticals and edible vaccines in plants
    • Daniell H, Streatfield SJ, Wycoff K. Medical molecular farming: production of antibodies, biopharmaceuticals and edible vaccines in plants. Trends Plant Sci 2001; 6: 219-26.
    • (2001) Trends Plant Sci , vol.6 , pp. 219-226
    • Daniell, H.1    Streatfield, S.J.2    Wycoff, K.3
  • 107
    • 14744293469 scopus 로고    scopus 로고
    • Antibody processing and engineering in plants, and new strategies for vaccine production
    • Ma JKC, Drake PMW, Chargelegue D, Obregon P, Prada A. Antibody processing and engineering in plants, and new strategies for vaccine production. Vaccine 2005; 23: 1814-8.
    • (2005) Vaccine , vol.23 , pp. 1814-1818
    • Ma, J.K.C.1    Drake, P.M.W.2    Chargelegue, D.3    Obregon, P.4    Prada, A.5
  • 108
    • 19444372752 scopus 로고    scopus 로고
    • Plant biopharming of monoclonal antibodies
    • Ko K, Koprowski H. Plant biopharming of monoclonal antibodies. Virus Research 2005; 111: 93-100.
    • (2005) Virus Research , vol.111 , pp. 93-100
    • Ko, K.1    Koprowski, H.2
  • 109
    • 0032775330 scopus 로고    scopus 로고
    • Metabolic engineering of plant secondary metabolite pathways for the production of fine chemicals
    • Verpoorte R, van der Heijden R, ten Hoopen HJG, Memelink J. Metabolic engineering of plant secondary metabolite pathways for the production of fine chemicals. Biotechnol Letters 1999; 21: 467-79.
    • (1999) Biotechnol Letters , vol.21 , pp. 467-479
    • Verpoorte, R.1    van der Heijden, R.2    ten Hoopen, H.J.G.3    Memelink, J.4
  • 110
    • 0033662249 scopus 로고    scopus 로고
    • Engineering the plant cell factory for secondary metabolite production
    • Verpoorte R, van der Heijden R, Memelink J. Engineering the plant cell factory for secondary metabolite production. Transgenic Res 2000; 9: 323-43.
    • (2000) Transgenic Res , vol.9 , pp. 323-343
    • Verpoorte, R.1    van der Heijden, R.2    Memelink, J.3
  • 111
    • 34250750268 scopus 로고    scopus 로고
    • Production and engineering of terpenoids in plant cell culture
    • Roberts SC. Production and engineering of terpenoids in plant cell culture. Nat Chem Biol 2007; 3: 387-95.
    • (2007) Nat Chem Biol , vol.3 , pp. 387-395
    • Roberts, S.C.1
  • 112
    • 4444351323 scopus 로고    scopus 로고
    • Plant cell factories in the postgenomic era: New ways to produce designer secondary metabolites
    • Oksman-Caldentey K-M, Inzé D. Plant cell factories in the postgenomic era: new ways to produce designer secondary metabolites. Trends in Plant Science 2004; 9: 433-40.
    • (2004) Trends in Plant Science , vol.9 , pp. 433-440
    • Oksman-Caldentey, K.-M.1    Inzé, D.2
  • 113
    • 34249935490 scopus 로고    scopus 로고
    • Genetic engineering approaches to improve bioethanol production from maize
    • Torney F, Moeller L, Scarpa A, Wang K. Genetic engineering approaches to improve bioethanol production from maize. Curr Opinion Biotechnol 2007; 18: 193-9.
    • (2007) Curr Opinion Biotechnol , vol.18 , pp. 193-199
    • Torney, F.1    Moeller, L.2    Scarpa, A.3    Wang, K.4
  • 114
    • 34447319626 scopus 로고    scopus 로고
    • Lignin modification improves fermentable sugar yields for biofuel production
    • Chen F, Dixon RA. Lignin modification improves fermentable sugar yields for biofuel production. Nat Biotech 2007; 25: 759-61.
    • (2007) Nat Biotech , vol.25 , pp. 759-761
    • Chen, F.1    Dixon, R.A.2
  • 115
    • 34548774616 scopus 로고    scopus 로고
    • Improved understanding of hyperaccumulation yields commercial phytoextraction and phytomining technologies J
    • Chaney RL, Angle JS, Broadhurst CL, Peters CA, Tappero RV, Sparks DL. Improved understanding of hyperaccumulation yields commercial phytoextraction and phytomining technologies J. Environ Qual 2007; 36: 1429-43.
    • (2007) Environ Qual , vol.36 , pp. 1429-1443
    • Chaney, R.L.1    Angle, J.S.2    Broadhurst, C.L.3    Peters, C.A.4    Tappero, R.V.5    Sparks, D.L.6
  • 116
    • 0035313503 scopus 로고    scopus 로고
    • Metabolic engineering and applications of flavonoids
    • Forkmann G, Martens S. Metabolic engineering and applications of flavonoids. Curr Opinion Biotechnol 2001; 12: 155-60.
    • (2001) Curr Opinion Biotechnol , vol.12 , pp. 155-160
    • Forkmann, G.1    Martens, S.2
  • 117
    • 0001760188 scopus 로고
    • Isoflavone composition of American and Japanese soybeans in Iowa: Effects of variety, crop year, and location
    • Wang H, Murphy PA. Isoflavone composition of American and Japanese soybeans in Iowa: effects of variety, crop year, and location. J Agricultural Food Chem 1994; 42: 1674-7.
    • (1994) J Agricultural Food Chem , vol.42 , pp. 1674-1677
    • Wang, H.1    Murphy, P.A.2
  • 118
    • 0030424065 scopus 로고    scopus 로고
    • Functional foods: Approaches to definition and substantiation
    • Head RJ, Record IR, King RA. Functional foods: approaches to definition and substantiation. Nutrition Rev 1996; 54: S17-S20.
    • (1996) Nutrition Rev , vol.54
    • Head, R.J.1    Record, I.R.2    King, R.A.3
  • 119
    • 0031731913 scopus 로고    scopus 로고
    • Glucose and lactate metabolism in C6 glioma cells: Evidence for the preferential utilization of lactate for cell oxidative metabolism
    • Bouzier AK, Voisin P, Goodwin R, Canioni P, Merle M. Glucose and lactate metabolism in C6 glioma cells: evidence for the preferential utilization of lactate for cell oxidative metabolism. Developmental Neuroscience 1998; 20: 331-8.
    • (1998) Developmental Neuroscience , vol.20 , pp. 331-338
    • Bouzier, A.K.1    Voisin, P.2    Goodwin, R.3    Canioni, P.4    Merle, M.5
  • 120
    • 0025866296 scopus 로고
    • Network rigidity and metabolic engineering in metabolite overproduction
    • Stephanopoulos G, Vallino JJ. Network rigidity and metabolic engineering in metabolite overproduction. Science 1991; 252: 1675-81.
    • (1991) Science , vol.252 , pp. 1675-1681
    • Stephanopoulos, G.1    Vallino, J.J.2
  • 121
    • 0035859039 scopus 로고    scopus 로고
    • Natural products and plant disease resistance
    • Dixon RA. Natural products and plant disease resistance. Nature 2001; 411: 843-7.
    • (2001) Nature , vol.411 , pp. 843-847
    • Dixon, R.A.1
  • 122
    • 0035793046 scopus 로고    scopus 로고
    • Metabolic engineering of plant alkaloid biosynthesis
    • Sato F, Hashimoto T, Hachiya A, et al. Metabolic engineering of plant alkaloid biosynthesis. Proc Natl Acad Sci 2001; 98: 367-372.
    • (2001) Proc Natl Acad Sci , vol.98 , pp. 367-372
    • Sato, F.1    Hashimoto, T.2    Hachiya, A.3
  • 123
    • 0035780976 scopus 로고    scopus 로고
    • Alkaloid biosynthesis in plants: Biochemistry, cell biology, molecular regulation, and metabolic engineering applications
    • Facchini PJ. Alkaloid biosynthesis in plants: Biochemistry, cell biology, molecular regulation, and metabolic engineering applications. Annu Rev Plant Physiol Plant Mol Biol 2001; 52: 29-66.
    • (2001) Annu Rev Plant Physiol Plant Mol Biol , vol.52 , pp. 29-66
    • Facchini, P.J.1
  • 125
    • 84856425174 scopus 로고    scopus 로고
    • Triterpenes production by rhizogenic callus of Salvia scabiosifolia Lam. obtained via Agrobacterium rhizogenes mediated genetic transformation
    • Marchev A, Georgiev V, Badjakov I, Kondakova V, Nikolova M, Pavlov A. Triterpenes production by rhizogenic callus of Salvia scabiosifolia Lam. obtained via Agrobacterium rhizogenes mediated genetic transformation. Biotechnol Biotechnol Equipment 2011; 25: 30-3.
    • (2011) Biotechnol Biotechnol Equipment , vol.25 , pp. 30-33
    • Marchev, A.1    Georgiev, V.2    Badjakov, I.3    Kondakova, V.4    Nikolova, M.5    Pavlov, A.6
  • 126
    • 80051473209 scopus 로고    scopus 로고
    • Twophase temporary immersion system for Agrobacterium rhizogenes genetic transformation of sage (Salvia tomentosa Mill.)
    • Marchev A, Georgiev V, Ivanov I, Badjakov I, Pavlov A. Twophase temporary immersion system for Agrobacterium rhizogenes genetic transformation of sage (Salvia tomentosa Mill.). Biotechnol Letters 2011; 33: 1873-8.
    • (2011) Biotechnol Letters , vol.33 , pp. 1873-1878
    • Marchev, A.1    Georgiev, V.2    Ivanov, I.3    Badjakov, I.4    Pavlov, A.5
  • 128
    • 0033983338 scopus 로고    scopus 로고
    • Engineering the provitamin A (β-carotene) biosynthetic pathway into (carotenoid-free) rice endosperm
    • Ye X, Al-Babili S, Klöti A, et al. Engineering the provitamin A (β-carotene) biosynthetic pathway into (carotenoid-free) rice endosperm. Science 2000; 287: 303-5.
    • (2000) Science , vol.287 , pp. 303-305
    • Ye, X.1    Al-Babili, S.2    Klöti, A.3
  • 129
    • 23644440517 scopus 로고    scopus 로고
    • Improving the nutritional value of Golden Rice through increased pro-vitamin A content
    • Paine JA, Shipton CA, Chaggar S, et al. Improving the nutritional value of Golden Rice through increased pro-vitamin A content. Nat Biotech 2005; 23: 482-7.
    • (2005) Nat Biotech , vol.23 , pp. 482-487
    • Paine, J.A.1    Shipton, C.A.2    Chaggar, S.3
  • 130
    • 33745148273 scopus 로고    scopus 로고
    • Understanding carotenoid metabolism as a necessity for genetic engineering of crop plants
    • Sandmann G, Römer S, Fraser PD. Understanding carotenoid metabolism as a necessity for genetic engineering of crop plants. Metabolic Engineering 2006; 8: 291-302.
    • (2006) Metabolic Engineering , vol.8 , pp. 291-302
    • Sandmann, G.1    Römer, S.2    Fraser, P.D.3
  • 131
    • 33751549337 scopus 로고    scopus 로고
    • Progress of vitamin E metabolic engineering in plants
    • Chen S, Li H, Liu G. Progress of vitamin E metabolic engineering in plants. Transgenic Res 2006; 15: 655-65.
    • (2006) Transgenic Res , vol.15 , pp. 655-665
    • Chen, S.1    Li, H.2    Liu, G.3
  • 132
    • 0033214408 scopus 로고    scopus 로고
    • Flavonoids and isoflavonoids-a gold mine for metabolic engineering
    • Dixon RA, Steele CL. Flavonoids and isoflavonoids-a gold mine for metabolic engineering. Trends Plant Sci 1999; 4: 394-400.
    • (1999) Trends Plant Sci , vol.4 , pp. 394-400
    • Dixon, R.A.1    Steele, C.L.2
  • 134
    • 0036536501 scopus 로고    scopus 로고
    • Improving iron, zinc and vitamin A nutrition through plant biotechnology
    • Zimmermann MB, Hurrell RF. Improving iron, zinc and vitamin A nutrition through plant biotechnology. Curr Opinion Biotechnol 2002; 13: 142-5.
    • (2002) Curr Opinion Biotechnol , vol.13 , pp. 142-145
    • Zimmermann, M.B.1    Hurrell, R.F.2
  • 135
    • 0023658666 scopus 로고
    • A new petunia flower colour generated by transformation of a mutant with a maize gene
    • Meyer P, Heidmann I, Forkmann G, Saedler H. A new petunia flower colour generated by transformation of a mutant with a maize gene. Nature 1987; 330: 677-8.
    • (1987) Nature , vol.330 , pp. 677-678
    • Meyer, P.1    Heidmann, I.2    Forkmann, G.3    Saedler, H.4
  • 136
    • 0001359591 scopus 로고
    • Introduction of a chimeric chalcone synthase gene into Petunia results in reversible co suppression of homologous genes in trans
    • Napoli C, Lemieux C, Jorgensen R. Introduction of a chimeric chalcone synthase gene into Petunia results in reversible co suppression of homologous genes in trans. Plant Cell Online 1990; 2: 279-89.
    • (1990) Plant Cell Online , vol.2 , pp. 279-289
    • Napoli, C.1    Lemieux, C.2    Jorgensen, R.3
  • 137
    • 0025405838 scopus 로고
    • Flavonoid genes in petunia: Addition of a limited number of gene copies may lead to a suppression of gene expression
    • van der Krol AR, Mur LA, Beld M, Mol JN, Stuitje AR. Flavonoid genes in petunia: addition of a limited number of gene copies may lead to a suppression of gene expression. Plant Cell Online 1990; 2: 291-9.
    • (1990) Plant Cell Online , vol.2 , pp. 291-299
    • van der Krol, A.R.1    Mur, L.A.2    Beld, M.3    Mol, J.N.4    Stuitje, A.R.5
  • 138
    • 0031931971 scopus 로고    scopus 로고
    • Distinct patterns of pigment suppression are produced by allelic sense and antisense chalcone synthase transgenes in petunia flowers
    • Que Q, Wang H-Y, Jorgensen RA. Distinct patterns of pigment suppression are produced by allelic sense and antisense chalcone synthase transgenes in petunia flowers. Plant J 1998; 13: 401-9.
    • (1998) Plant J , vol.13 , pp. 401-409
    • Que, Q.1    Wang, H.-Y.2    Jorgensen, R.A.3
  • 139
    • 0030942554 scopus 로고    scopus 로고
    • RNA-mediated RNA degradation and chalcone synthase A silencing in Petunia
    • Metzlaff M, O'Dell M, Cluster PD, Flavell RB. RNA-mediated RNA degradation and chalcone synthase A silencing in Petunia. Cell 1997; 88: 845-54.
    • (1997) Cell , vol.88 , pp. 845-854
    • Metzlaff, M.1    O'Dell, M.2    Cluster, P.D.3    Flavell, R.B.4
  • 140
    • 3042756214 scopus 로고    scopus 로고
    • Flower color modulations of Torenia hybrida by downregulation of chalcone synthase genes with RNA interference
    • Fukusaki EI, Kawasaki K, Kajiyama SI, et al. Flower color modulations of Torenia hybrida by downregulation of chalcone synthase genes with RNA interference. J Biotechnol 2004; 111: 229-40.
    • (2004) J Biotechnol , vol.111 , pp. 229-240
    • Fukusaki, E.I.1    Kawasaki, K.2    Kajiyama, S.I.3
  • 141
    • 0026654039 scopus 로고
    • Biochemical complementation of chalcone synthase mutants defines a role for flavonols in functional pollen
    • Mo Y, Nagel C, Taylor LP. Biochemical complementation of chalcone synthase mutants defines a role for flavonols in functional pollen. Proc Natl Acad Sci 1992; 89: 7213-7.
    • (1992) Proc Natl Acad Sci , vol.89 , pp. 7213-7217
    • Mo, Y.1    Nagel, C.2    Taylor, L.P.3
  • 142
    • 0028094003 scopus 로고
    • Flavonols and fertilization in Petunia hybrida: Localization and mode of action during pollen tube growth
    • Ylstra B, Busscher J, Franken J, Hollman PCH, Mol JNM, Van Tunen AJ. Flavonols and fertilization in Petunia hybrida: localization and mode of action during pollen tube growth. Plant J 1994; 6: 201-12.
    • (1994) Plant J , vol.6 , pp. 201-212
    • Ylstra, B.1    Busscher, J.2    Franken, J.3    Hollman, P.C.H.4    Mol, J.N.M.5    Van Tunen, A.J.6
  • 143
    • 34447132250 scopus 로고    scopus 로고
    • RNA interference silencing of chalcone synthase, the first step in the flavonoid biosynthesis pathway, leads to parthenocarpic tomato fruits
    • Schijlen EGWM, de Vos CHR, Martens S, et al. RNA interference silencing of chalcone synthase, the first step in the flavonoid biosynthesis pathway, leads to parthenocarpic tomato fruits. Plant Physiol 2007; 144: 1520-30.
    • (2007) Plant Physiol , vol.144 , pp. 1520-1530
    • Schijlen, E.G.W.M.1    de Vos, C.H.R.2    Martens, S.3
  • 145
    • 36248930332 scopus 로고    scopus 로고
    • Engineering of the rose flavonoid biosynthetic pathway successfully generated blue-hued flowers accumulating delphinidin
    • Katsumoto Y, Fukuchi-Mizutani M, Fukui Y, et al. Engineering of the rose flavonoid biosynthetic pathway successfully generated blue-hued flowers accumulating delphinidin. Plant Cell Physiol 2007; 48: 1589-600.
    • (2007) Plant Cell Physiol , vol.48 , pp. 1589-1600
    • Katsumoto, Y.1    Fukuchi-Mizutani, M.2    Fukui, Y.3
  • 146
    • 33748295746 scopus 로고    scopus 로고
    • Transgenic flavonoid tomato intake reduces C-reactive protein in human C-reactive protein transgenic mice more than wild-type tomato
    • Rein D, Schijlen E, Kooistra T, et al. Transgenic flavonoid tomato intake reduces C-reactive protein in human C-reactive protein transgenic mice more than wild-type tomato. The J Nutrition 2006; 136: 2331-7.
    • (2006) The J Nutrition , vol.136 , pp. 2331-2337
    • Rein, D.1    Schijlen, E.2    Kooistra, T.3
  • 148
    • 69949164190 scopus 로고    scopus 로고
    • Plant cells and algae in bioreactors
    • Pavlov A. Plant cells and algae in bioreactors. Engineering Life Sci 2009; 9: 154-5.
    • (2009) Engineering Life Sci , vol.9 , pp. 154-155
    • Pavlov, A.1
  • 150
    • 84887947275 scopus 로고    scopus 로고
    • Bioreactors for the cultivation of red beet hairy roots
    • Springer US, In: Neelwarne B, ed
    • Georgiev VG, Bley T, Pavlov AI. Bioreactors for the cultivation of red beet hairy roots. In: Neelwarne B, ed., Red Beet Biotechnology. Springer US 2012; pp. 251-81.
    • (2012) Red Beet Biotechnology , pp. 251-281
    • Georgiev, V.G.1    Bley, T.2    Pavlov, A.I.3
  • 151
    • 77950824585 scopus 로고    scopus 로고
    • Volatile metabolic profiles of cell suspension cultures of Lavandula vera, Nicotiana tabacum and Helianthus annuus, cultivated under different regimes
    • Georgiev M, Georgiev V, Penchev P, et al. Volatile metabolic profiles of cell suspension cultures of Lavandula vera, Nicotiana tabacum and Helianthus annuus, cultivated under different regimes. Engineering Life Sci 2010; 10: 148-57.
    • (2010) Engineering Life Sci , vol.10 , pp. 148-157
    • Georgiev, M.1    Georgiev, V.2    Penchev, P.3
  • 152
    • 77953323455 scopus 로고    scopus 로고
    • Antioxidant activity and phenolic content of betalain extracts from intact plants and hairy root cultures of the red beetroot Beta vulgaris cv. Detroit Dark Red
    • Georgiev V, Weber J, Kneschke EM, Denev P, Bley T, Pavlov A. Antioxidant activity and phenolic content of betalain extracts from intact plants and hairy root cultures of the red beetroot Beta vulgaris cv. Detroit Dark Red. Plant Foods Human Nutrition 2010; 65: 105-11.
    • (2010) Plant Foods Human Nutrition , vol.65 , pp. 105-111
    • Georgiev, V.1    Weber, J.2    Kneschke, E.M.3    Denev, P.4    Bley, T.5    Pavlov, A.6
  • 153
    • 17644391449 scopus 로고    scopus 로고
    • Elicitor signal transduction leading to production of plant secondary metabolites
    • Zhao J, Davis LC, Verpoorte R. Elicitor signal transduction leading to production of plant secondary metabolites. Biotechnol Adv 2005; 23: 283-333.
    • (2005) Biotechnol Adv , vol.23 , pp. 283-333
    • Zhao, J.1    Davis, L.C.2    Verpoorte, R.3
  • 154
    • 80053914814 scopus 로고    scopus 로고
    • A combination of elicitation and precursor feeding leads to increased anthocyanin synthesis in cell suspension cultures of Vitis vinifera
    • Qu J, Zhang W, Yu X. A combination of elicitation and precursor feeding leads to increased anthocyanin synthesis in cell suspension cultures of Vitis vinifera. Plant Cell, Tissue Organ Culture 2011; 107: 261-9.
    • (2011) Plant Cell, Tissue Organ Culture , vol.107 , pp. 261-269
    • Qu, J.1    Zhang, W.2    Yu, X.3
  • 155
    • 84856531965 scopus 로고    scopus 로고
    • Polysaccharide elicitors enhance anthocyanin and phenolic acid accumulation in cell suspension cultures of Vitis vinifera
    • Cai Z, Kastell A, Mewis I, Knorr D, Smetanska I. Polysaccharide elicitors enhance anthocyanin and phenolic acid accumulation in cell suspension cultures of Vitis vinifera. Plant Cell, Tissue Organ Culture 2012; 108: 401-9.
    • (2012) Plant Cell, Tissue Organ Culture , vol.108 , pp. 401-409
    • Cai, Z.1    Kastell, A.2    Mewis, I.3    Knorr, D.4    Smetanska, I.5
  • 156
    • 82455171900 scopus 로고    scopus 로고
    • Enhanced anthocyanins and resveratrol production in Vitis vinifera cell suspension culture by indanoyl-isoleucine, N-linolenoyl-l-glutamine and insect saliva
    • Cai Z, Knorr D, Smetanska I. Enhanced anthocyanins and resveratrol production in Vitis vinifera cell suspension culture by indanoyl-isoleucine, N-linolenoyl-l-glutamine and insect saliva. Enzyme Microbial Technol 2012; 50: 29-34.
    • (2012) Enzyme Microbial Technol , vol.50 , pp. 29-34
    • Cai, Z.1    Knorr, D.2    Smetanska, I.3
  • 157
    • 79957850637 scopus 로고    scopus 로고
    • Effects of elicitors and high hydrostatic pressure on secondary metabolism of Vitis vinifera suspension culture
    • Cai Z, Riedel H, Saw NMMT, et al. Effects of elicitors and high hydrostatic pressure on secondary metabolism of Vitis vinifera suspension culture. Process Biochem 2011; 46: 1411-6.
    • (2011) Process Biochem , vol.46 , pp. 1411-1416
    • Cai, Z.1    Riedel, H.2    Saw, N.M.M.T.3
  • 158
    • 79955798320 scopus 로고    scopus 로고
    • Effects of pulsed electric field on secondary metabolism of Vitis vinifera L. cv. Gamay Fréaux suspension culture and exudates
    • Cai Z, Riedel H, Thaw Saw N, et al. Effects of pulsed electric field on secondary metabolism of Vitis vinifera L. cv. Gamay Fréaux suspension culture and exudates. Applied Biochem Biotechnol 2011; 164: 443-53.
    • (2011) Applied Biochem Biotechnol , vol.164 , pp. 443-453
    • Cai, Z.1    Riedel, H.2    Thaw Saw, N.3
  • 159
    • 81555197109 scopus 로고    scopus 로고
    • Stimulation of anthocyanin synthesis in grape (Vitis vinifera) cell cultures by pulsed electric fields and ethephon
    • Saw N, Riedel H, Cai Z, Kütük O, Smetanska I. Stimulation of anthocyanin synthesis in grape (Vitis vinifera) cell cultures by pulsed electric fields and ethephon. Plant Cell, Tissue Organ Culture 2012; 108: 47-54.
    • (2012) Plant Cell, Tissue Organ Culture , vol.108 , pp. 47-54
    • Saw, N.1    Riedel, H.2    Cai, Z.3    Kütük, O.4    Smetanska, I.5
  • 160
    • 80052590353 scopus 로고    scopus 로고
    • Effects of elicitors on the production of resveratrol and viniferins in cell cultures of Vitis vinifera L. cv Italia
    • Santamaria AR, Mulinacci N, Valletta A, Innocenti M, Pasqua G. Effects of elicitors on the production of resveratrol and viniferins in cell cultures of Vitis vinifera L. cv Italia. J Agricultural Food Chem 2011; 59: 9094-101.
    • (2011) J Agricultural Food Chem , vol.59 , pp. 9094-9101
    • Santamaria, A.R.1    Mulinacci, N.2    Valletta, A.3    Innocenti, M.4    Pasqua, G.5
  • 161
    • 85037116047 scopus 로고    scopus 로고
    • Elicitation and precursor feeding influence phenolic acids composition in Vitis vinifera suspension culture
    • Riedel H, Akumo DN, Saw NMMT, Kütük O, Neubauer P, Smetanska I. Elicitation and precursor feeding influence phenolic acids composition in Vitis vinifera suspension culture. African J Biotechnol 2012; 11: 3000-8.
    • (2012) African J Biotechnol , vol.11 , pp. 3000-3008
    • Riedel, H.1    Akumo, D.N.2    Saw, N.M.M.T.3    Kütük, O.4    Neubauer, P.5    Smetanska, I.6
  • 162
    • 79953219019 scopus 로고    scopus 로고
    • Bioproduction of resveratrol and viniferins by an elicited grapevine cell culture in a 2 L stirred bioreactor
    • Donnez D, Kim KH, Antoine S, et al. Bioproduction of resveratrol and viniferins by an elicited grapevine cell culture in a 2 L stirred bioreactor. Process Biochem 2011; 46: 1056-62.
    • (2011) Process Biochem , vol.46 , pp. 1056-1062
    • Donnez, D.1    Kim, K.H.2    Antoine, S.3
  • 163
    • 70449730481 scopus 로고    scopus 로고
    • Bioproduction of resveratrol and stilbene derivatives by plant cells and microorganisms
    • Donnez D, Jeandet P, Clément C, Courot E. Bioproduction of resveratrol and stilbene derivatives by plant cells and microorganisms. Trends in Biotechnol 2009; 27: 706-13.
    • (2009) Trends in Biotechnol , vol.27 , pp. 706-713
    • Donnez, D.1    Jeandet, P.2    Clément, C.3    Courot, E.4
  • 164
    • 0141719702 scopus 로고    scopus 로고
    • Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
    • Howitz KT, Bitterman KJ, Cohen HY, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003; 425: 191-6.
    • (2003) Nature , vol.425 , pp. 191-196
    • Howitz, K.T.1    Bitterman, K.J.2    Cohen, H.Y.3
  • 166
    • 34247898848 scopus 로고    scopus 로고
    • Estimated dietary flavonoid intake and major food sources of U.S. adults
    • Chun OK, Chung SJ, Song WO. Estimated dietary flavonoid intake and major food sources of U. S. adults. J Nutrition 2007; 137: 1244-52.
    • (2007) J Nutrition , vol.137 , pp. 1244-1252
    • Chun, O.K.1    Chung, S.J.2    Song, W.O.3
  • 167
    • 21544437419 scopus 로고    scopus 로고
    • Intake of phytochemicals among Japanese, calculated by the new FFF database
    • Kita J, Tada J, Ito M, et al. Intake of phytochemicals among Japanese, calculated by the new FFF database. BioFactors 2004; 22: 259-63.
    • (2004) BioFactors , vol.22 , pp. 259-263
    • Kita, J.1    Tada, J.2    Ito, M.3
  • 170
    • 33847789892 scopus 로고    scopus 로고
    • Flavonoid intake and cardiovascular disease mortality: A prospective study in postmenopausal women
    • Mink PJ, Scrafford CG, Barraj LM, et al. Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women. Am J Clinical Nutrition 2007; 85: 895-909.
    • (2007) Am J Clinical Nutrition , vol.85 , pp. 895-909
    • Mink, P.J.1    Scrafford, C.G.2    Barraj, L.M.3
  • 171
    • 1542286856 scopus 로고    scopus 로고
    • Concentrations of proanthocyanidins in common foods and estimations of normal consumption
    • Gu L, Kelm MA, Hammerstone JF, et al. Concentrations of proanthocyanidins in common foods and estimations of normal consumption. J Nutrition 2004; 134: 613-7.
    • (2004) J Nutrition , vol.134 , pp. 613-617
    • Gu, L.1    Kelm, M.A.2    Hammerstone, J.F.3
  • 172
    • 0028216956 scopus 로고
    • Soy intake and cancer risk: A review of the in vitro and in vivo data
    • Messina MJ, Persky V, Setchell KDR, Barnes S. Soy intake and cancer risk: A review of the in vitro and in vivo data. Nutrition Cancer 1994; 21: 113-31.
    • (1994) Nutrition Cancer , vol.21 , pp. 113-131
    • Messina, M.J.1    Persky, V.2    Setchell, K.D.R.3    Barnes, S.4
  • 173
    • 0037799103 scopus 로고    scopus 로고
    • Alternatives to HRT: An evidence-based review
    • Taylor M. Alternatives to HRT: an evidence-based review. Int J Fertil Womens Med 2003; 48: 64-8.
    • (2003) Int J Fertil Womens Med , vol.48 , pp. 64-68
    • Taylor, M.1
  • 174
    • 0037173755 scopus 로고    scopus 로고
    • The nature and utility of the phytoestrogens: A review of the evidence
    • Albertazzi P, Purdie D. The nature and utility of the phytoestrogens: a review of the evidence. Maturitas 2002; 42: 173-85.
    • (2002) Maturitas , vol.42 , pp. 173-185
    • Albertazzi, P.1    Purdie, D.2
  • 175
    • 0038613123 scopus 로고    scopus 로고
    • Phyto-oestrogens and osteoporosis: What is a safe dose?
    • Barnes S. Phyto-oestrogens and osteoporosis: what is a safe dose? Br J Nutrition 2003; 89: S101-S108.
    • (2003) Br J Nutrition , vol.89
    • Barnes, S.1
  • 176
    • 0141889027 scopus 로고    scopus 로고
    • Role of isoflavones in the hypocholesterolemic effect of soy
    • Demonty I, Lamarche B, Jones PJH. Role of isoflavones in the hypocholesterolemic effect of soy. Nutrition Rev 2003; 61: 189-203.
    • (2003) Nutrition Rev , vol.61 , pp. 189-203
    • Demonty, I.1    Lamarche, B.2    Jones, P.J.H.3
  • 177
    • 0346726203 scopus 로고    scopus 로고
    • Proteins of white lupin seed, a naturally isoflavone-poor legume, reduce cholesterolemia in rats and increase LDL receptor activity in HepG2 cells
    • Sirtori CR, Lovati MR, Manzoni C, et al. Proteins of white lupin seed, a naturally isoflavone-poor legume, reduce cholesterolemia in rats and increase LDL receptor activity in HepG2 cells. J Nutrition 2004; 134: 18-23.
    • (2004) J Nutrition , vol.134 , pp. 18-23
    • Sirtori, C.R.1    Lovati, M.R.2    Manzoni, C.3
  • 178
    • 0036173396 scopus 로고    scopus 로고
    • Neurobehavioral effects of dietary soy phytoestrogens
    • Lephart ED, West TW, Weber KS, et al. Neurobehavioral effects of dietary soy phytoestrogens. Neurotoxicol Teratol 2002; 24: 5-16.
    • (2002) Neurotoxicol Teratol , vol.24 , pp. 5-16
    • Lephart, E.D.1    West, T.W.2    Weber, K.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.