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Volumn 28, Issue 6, 2013, Pages 423-431

Mechanism and physiological significance of growth factor-related autophagy

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE B; SIGNAL PEPTIDE;

EID: 84887093100     PISSN: 15489213     EISSN: 15489221     Source Type: Journal    
DOI: 10.1152/physiol.00023.2013     Document Type: Review
Times cited : (11)

References (147)
  • 2
    • 73449117508 scopus 로고    scopus 로고
    • Targeted deletion of autophagy-related 5 (atg5) impairs adipogenesis in a cellular model and in mice
    • Baerga R, Zhang Y, Chen PH, Goldman S, Jin S. Targeted deletion of autophagy-related 5 (atg5) impairs adipogenesis in a cellular model and in mice. Autophagy 5: 1118-1130, 2009.
    • (2009) Autophagy , vol.5 , pp. 1118-1130
    • Baerga, R.1    Zhang, Y.2    Chen, P.H.3    Goldman, S.4    Jin, S.5
  • 4
    • 77954237882 scopus 로고    scopus 로고
    • Network organization of the human autophagy system
    • Behrends C, Sowa ME, Gygi SP, Harper JW. Network organization of the human autophagy system. Nature 466: 68-76, 2010.
    • (2010) Nature , vol.466 , pp. 68-76
    • Behrends, C.1    Sowa, M.E.2    Gygi, S.P.3    Harper, J.W.4
  • 5
    • 80051680291 scopus 로고    scopus 로고
    • A continuum model for tumour suppression
    • Berger AH, Knudson AG, Pandolfi PP. A continuum model for tumour suppression. Nature 476: 163-169, 2011.
    • (2011) Nature , vol.476 , pp. 163-169
    • Berger, A.H.1    Knudson, A.G.2    Pandolfi, P.P.3
  • 6
    • 0035499454 scopus 로고    scopus 로고
    • Ten years of protein kinase B signalling: A hard Akt to follow
    • Brazil DP, Hemmings BA. Ten years of protein kinase B signalling: a hard Akt to follow. Trends Biochem Sci 26: 657-664, 2001.
    • (2001) Trends Biochem Sci , vol.26 , pp. 657-664
    • Brazil, D.P.1    Hemmings, B.A.2
  • 8
    • 0029160069 scopus 로고
    • Protein kinase B (c-Akt) in phos-phatidylinositol-3-OH kinase signal transduction
    • Burgering BM, Coffer PJ. Protein kinase B (c-Akt) in phos-phatidylinositol-3-OH kinase signal transduction. Nature 376: 599-602, 1995.
    • (1995) Nature , vol.376 , pp. 599-602
    • Burgering, B.M.1    Coffer, P.J.2
  • 9
  • 10
    • 77949452524 scopus 로고    scopus 로고
    • The PKB/AKT pathway in cancer
    • Carnero A. The PKB/AKT pathway in cancer. Curr Pharm Des 16: 34-44, 2010.
    • (2010) Curr Pharm Des , vol.16 , pp. 34-44
    • Carnero, A.1
  • 13
    • 84863661689 scopus 로고    scopus 로고
    • Therapeutic targets in cancer cell metabolism and autophagy
    • Cheong H, Lu C, Lindsten T, Thompson CB. Therapeutic targets in cancer cell metabolism and autophagy. Nat Bio-technol 30: 671-678, 2012.
    • (2012) Nat Bio-technol , vol.30 , pp. 671-678
    • Cheong, H.1    Lu, C.2    Lindsten, T.3    Thompson, C.B.4
  • 14
    • 84877628647 scopus 로고    scopus 로고
    • Autophagy in human health and disease
    • Choi AM, Ryter SW, Levine B. Autophagy in human health and disease. N Engl J Med 368: 651-662, 2013.
    • (2013) N Engl J Med , vol.368 , pp. 651-662
    • Choi, A.M.1    Ryter, S.W.2    Levine, B.3
  • 16
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378: 785-789, 1995.
    • (1995) Nature , vol.378 , pp. 785-789
    • Cross, D.A.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 17
    • 33644513730 scopus 로고    scopus 로고
    • Beyond PTEN mutations: The PI3K pathway as an integrator of multiple inputs during tumorigenesis
    • Cully M, You H, Levine AJ, Mak TW. Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer 6: 184-192, 2006.
    • (2006) Nat Rev Cancer , vol.6 , pp. 184-192
    • Cully, M.1    You, H.2    Levine, A.J.3    Mak, T.W.4
  • 18
    • 33846005164 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase-dependent modulation of carnitine palmitoyltrans-ferase 1A expression regulates lipid metabolism during he-matopoietic cell growth
    • Deberardinis RJ, Lum JJ, Thompson CB. Phosphatidylinositol 3-kinase-dependent modulation of carnitine palmitoyltrans-ferase 1A expression regulates lipid metabolism during he-matopoietic cell growth. J Biol Chem 281: 37372-37380, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 37372-37380
    • Deberardinis, R.J.1    Lum, J.J.2    Thompson, C.B.3
  • 19
    • 78650918920 scopus 로고    scopus 로고
    • FOXO/4E-BP signaling in Drosoph-ila muscles regulates organism-wide proteostasis during aging
    • Demontis F, Perrimon N. FOXO/4E-BP signaling in Drosoph-ila muscles regulates organism-wide proteostasis during aging. Cell 143: 813-825, 2010.
    • (2010) Cell , vol.143 , pp. 813-825
    • Demontis, F.1    Perrimon, N.2
  • 22
    • 84872899284 scopus 로고    scopus 로고
    • FOXOs: Signalling integrators for homeostasis maintenance
    • Eijkelenboom A, Burgering BM. FOXOs: signalling integrators for homeostasis maintenance. Nat Rev Mol Cell Biol 14: 83-97, 2013.
    • (2013) Nat Rev Mol Cell Biol , vol.14 , pp. 83-97
    • Eijkelenboom, A.1    Burgering, B.M.2
  • 24
    • 84859902396 scopus 로고    scopus 로고
    • Growth factors, nutrient signaling, and cardiovascular aging
    • Fontana L, Vinciguerra M, Longo VD. Growth factors, nutrient signaling, and cardiovascular aging. Circ Res 110: 1139-1150, 2012.
    • (2012) Circ Res , vol.110 , pp. 1139-1150
    • Fontana, L.1    Vinciguerra, M.2    Longo, V.D.3
  • 25
    • 66449083078 scopus 로고    scopus 로고
    • Jiang XULK1. ATG13. FIP200 complex mediates mTOR signaling and is essential for autophagy
    • Ganley IG, Lam H, Wang J, Ding X, Chen S, Jiang XULK1. ATG13. FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol Chem 284: 12297-12305, 2009.
    • (2009) J Biol Chem , vol.284 , pp. 12297-12305
    • Ganley, I.G.1    Lam, H.2    Wang, J.3    Ding, X.4    Chen, S.5
  • 26
    • 0034982971 scopus 로고    scopus 로고
    • TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth
    • Gao X, Pan D. TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth. Genes Dev 15: 1383-1392, 2001.
    • (2001) Genes Dev , vol.15 , pp. 1383-1392
    • Gao, X.1    Pan, D.2
  • 28
    • 2442482810 scopus 로고    scopus 로고
    • Autophagy as a cell death and tumor suppressor mechanism
    • Gozuacik D, Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene 23: 2891-2906, 2004.
    • (2004) Oncogene , vol.23 , pp. 2891-2906
    • Gozuacik, D.1    Kimchi, A.2
  • 29
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 144: 646-674, 2011.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 30
    • 84858782079 scopus 로고    scopus 로고
    • AMPK: A nutrient and energy sensor that maintains energy homeostasis
    • Hardie DG, Ross FA, Hawley SA. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol 13: 251-262, 2012.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 251-262
    • Hardie, D.G.1    Ross, F.A.2    Hawley, S.A.3
  • 34
    • 33646828975 scopus 로고    scopus 로고
    • Insulin antagonizes ischemia-induced Thr172 phosphor-ylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491
    • Horman S, Vertommen D, Heath R, Neumann D, Mouton V, Woods A, Schlattner U, Wallimann T, Carling D, Hue L, Rider MH. Insulin antagonizes ischemia-induced Thr172 phosphor-ylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491. J Biol Chem 281: 5335-5340, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 5335-5340
    • Horman, S.1    Vertommen, D.2    Heath, R.3    Neumann, D.4    Mouton, V.5    Woods, A.6    Schlattner, U.7    Wallimann, T.8    Carling, D.9    Hue, L.10    Rider, M.H.11
  • 36
    • 84859385707 scopus 로고    scopus 로고
    • Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma
    • Hu YL, DeLay M, Jahangiri A, Molinaro AM, Rose SD, Carbo-nell WS, Aghi MK. Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma. Cancer Res 72: 1773-1783, 2012.
    • (2012) Cancer Res , vol.72 , pp. 1773-1783
    • Hu, Y.L.1    Delay, M.2    Jahangiri, A.3    Molinaro, A.M.4    Rose, S.D.5    Carbo-Nell, W.S.6    Aghi, M.K.7
  • 37
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    • Inoki K, Li Y, Zhu T, Wu J, Guan KL TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 4: 648-657, 2002.
    • (2002) Nat Cell Biol , vol.4 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.L.5
  • 39
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell 115: 577-590, 2003.
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 41
    • 84884676252 scopus 로고    scopus 로고
    • Nutrient signaling to mTOR and cell growth
    • Jewell JL, Guan KL. Nutrient signaling to mTOR and cell growth. Trends Biochem Sci 38: 233-242, 2013.
    • (2013) Trends Biochem Sci , vol.38 , pp. 233-242
    • Jewell, J.L.1    Guan, K.L.2
  • 42
    • 33747863220 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 and TNF-a regulate autophagy through c-jun N-terminal kinase and AKT pathways in human atherosclerotic vascular smooth cells
    • Jia G, Cheng G, Gangahar DM, Agrawal DK. Insulin-like growth factor-1 and TNF-a regulate autophagy through c-jun N-terminal kinase and AKT pathways in human atherosclerotic vascular smooth cells. Immunol Cell Biol 84: 448-454, 2006.
    • (2006) Immunol Cell Biol , vol.84 , pp. 448-454
    • Jia, G.1    Cheng, G.2    Gangahar, D.M.3    Agrawal, D.K.4
  • 43
    • 0037041470 scopus 로고    scopus 로고
    • Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus
    • Jia J, Amanai K, Wang G, Tang J, Wang B, Jiang J. Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus. Nature 416: 548-552, 2002.
    • (2002) Nature , vol.416 , pp. 548-552
    • Jia, J.1    Amanai, K.2    Wang, G.3    Tang, J.4    Wang, B.5    Jiang, J.6
  • 44
    • 67649814136 scopus 로고    scopus 로고
    • PI3K/PTEN signaling in angio-genesis and tumorigenesis
    • Jiang BH, Liu LZ. PI3K/PTEN signaling in angio-genesis and tumorigenesis. Adv Cancer Res 102: 19-65, 2009.
    • (2009) Adv Cancer Res , vol.102 , pp. 19-65
    • Jiang, B.H.1    Liu, L.Z.2
  • 46
    • 84864318195 scopus 로고    scopus 로고
    • Chaperone-mediated autophagy: A unique way to enter the lysosome world
    • Kaushik S, Cuervo AM. Chaperone-mediated autophagy: a unique way to enter the lysosome world. Trends Cell Biol 22: 407-417, 2012.
    • (2012) Trends Cell Biol , vol.22 , pp. 407-417
    • Kaushik, S.1    Cuervo, A.M.2
  • 47
    • 79551598347 scopus 로고    scopus 로고
    • AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
    • Kim J, Kundu M, Viollet B, Guan KL. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 13: 132-141, 2011.
    • (2011) Nat Cell Biol , vol.13 , pp. 132-141
    • Kim, J.1    Kundu, M.2    Viollet, B.3    Guan, K.L.4
  • 48
    • 80053634368 scopus 로고    scopus 로고
    • The dynamic nature of autophagy in cancer
    • Kimmelman AC. The dynamic nature of autophagy in cancer. Genes Dev 25: 1999-2010, 2011.
    • (2011) Genes Dev , vol.25 , pp. 1999-2010
    • Kimmelman, A.C.1
  • 49
    • 71549124671 scopus 로고    scopus 로고
    • Autophagy is activated by TGF-b and potentiates TGF-3-mediated growth inhibition in human hepatocellular carcinoma cells
    • Kiyono K, Suzuki HI, Matsuyama H, Morishita Y, Komuro A, Kano MR, Sugimoto K, Miyazono K. Autophagy is activated by TGF-b and potentiates TGF-3-mediated growth inhibition in human hepatocellular carcinoma cells. Cancer Res 69: 8844-8852, 2009.
    • (2009) Cancer Res , vol.69 , pp. 8844-8852
    • Kiyono, K.1    Suzuki, H.I.2    Matsuyama, H.3    Morishita, Y.4    Komuro, A.5    Kano, M.R.6    Sugimoto, K.7    Miyazono, K.8
  • 51
    • 84869124927 scopus 로고    scopus 로고
    • Cell biology. Promoting tumorigenesis by suppressing autophagy
    • Koren I, Kimchi A. Cell biology. Promoting tumorigenesis by suppressing autophagy. Science 338: 889-890, 2012.
    • (2012) Science , vol.338 , pp. 889-890
    • Koren, I.1    Kimchi, A.2
  • 52
    • 0141925771 scopus 로고    scopus 로고
    • Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart
    • Kovacic S, Soltys CL, Barr AJ, Shiojima I, Walsh K, Dyck JR. Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart. J Biol Chem 278: 39422-39427, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 39422-39427
    • Kovacic, S.1    Soltys, C.L.2    Barr, A.J.3    Shiojima, I.4    Walsh, K.5    Dyck, J.R.6
  • 55
    • 56749170677 scopus 로고    scopus 로고
    • Autophagic cell death: The story of a misnomer
    • Kroemer G, Levine B. Autophagic cell death: the story of a misnomer. Nat Rev Mol Cell Biol 9: 1004-1010, 2008.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 1004-1010
    • Kroemer, G.1    Levine, B.2
  • 56
    • 78649338141 scopus 로고    scopus 로고
    • Autophagy and the integrated stress response
    • Kroemer G, Mariño G, Levine B. Autophagy and the integrated stress response. Mol Cell 40: 280, 2010.
    • (2010) Mol Cell , vol.40 , pp. 280
    • Kroemer, G.1    Mariño, G.2    Levine, B.3
  • 58
    • 84883253496 scopus 로고    scopus 로고
    • A targeted genetic modifier screen links the SWI2/ SNF2 protein domino to growth and autophagy genes in Drosophila melanogaster
    • Kwon MH, Callaway H, Zhong J, Yedvobnick B. A targeted genetic modifier screen links the SWI2/ SNF2 protein domino to growth and autophagy genes in Drosophila melanogaster. G3 (Be-thesda) 3: 815-825, 2013.
    • (2013) G3 (Be-thesda) , vol.3 , pp. 815-825
    • Kwon, M.H.1    Callaway, H.2    Zhong, J.3    Yedvobnick, B.4
  • 59
    • 84859778293 scopus 로고    scopus 로고
    • mTOR signaling in growth control and disease
    • Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell 149: 274-293, 2012.
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 60
    • 33947134377 scopus 로고    scopus 로고
    • Autophagy-dependent viral recognition by plasmacytoid dendritic cells
    • Lee HK, Lund JM, Ramanathan B, Mizushima N, Iwasaki A. Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science 315: 1398-1401, 2007.
    • (2007) Science , vol.315 , pp. 1398-1401
    • Lee, H.K.1    Lund, J.M.2    Ramanathan, B.3    Mizushima, N.4    Iwasaki, A.5
  • 61
    • 0034495033 scopus 로고    scopus 로고
    • Age-related changes of serum sex hormones, insulin-like growth fac-tor-1 and sex-hormone binding globulin levels in men: Cross-sectional data from a healthy male cohort
    • Leifke E, Gorenoi V, Wichers C, Von ZurMuhlen A, Von Buren E, Brabant G. Age-related changes of serum sex hormones, insulin-like growth fac-tor-1 and sex-hormone binding globulin levels in men: cross-sectional data from a healthy male cohort. Clin Endocrinol (Oxf) 53: 689-695, 2000.
    • (2000) Clin Endocrinol (Oxf) , vol.53 , pp. 689-695
    • Leifke, E.1    Gorenoi, V.2    Wichers, C.3    von Zurmuhlen, A.4    von Buren, E.5    Brabant, G.6
  • 62
    • 77953896432 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Lemmon MA, Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 141: 1117-1134, 2010.
    • (2010) Cell , vol.141 , pp. 1117-1134
    • Lemmon, M.A.1    Schlessinger, J.2
  • 63
    • 78649711427 scopus 로고    scopus 로고
    • The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes
    • Levine AJ, Puzio-Kuter AM. The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes. Science 330: 1340-1344, 2010.
    • (2010) Science , vol.330 , pp. 1340-1344
    • Levine, A.J.1    Puzio-Kuter, A.M.2
  • 65
    • 84864805916 scopus 로고    scopus 로고
    • Autophagy and cancer: Issues we need to digest
    • Liu EY, Ryan KM. Autophagy and cancer: issues we need to digest. J Cell Sci 125: 2349-2358, 2012.
    • (2012) J Cell Sci , vol.125 , pp. 2349-2358
    • Liu, E.Y.1    Ryan, K.M.2
  • 66
    • 84877336464 scopus 로고    scopus 로고
    • Interleukin 17A inhibits autophagy through activation of PIK3CA to interrupt the GSK3B-mediated degradation of BCL2 in lung epithelial cells
    • Liu H, Mi S, Li Z, Hua F, Hu ZW. Interleukin 17A inhibits autophagy through activation of PIK3CA to interrupt the GSK3B-mediated degradation of BCL2 in lung epithelial cells. Autophagy 9: 730-742, 2013.
    • (2013) Autophagy , vol.9 , pp. 730-742
    • Liu, H.1    Mi, S.2    Li, Z.3    Hua, F.4    Hu, Z.W.5
  • 67
    • 84868150657 scopus 로고    scopus 로고
    • Albumin prevents reactive oxygen species-induced mito-chondrial damage, autophagy, and apoptosis during serum starvation
    • Liu SY, Chen CL, Yang TT, Huang WC, Hsieh CY, Shen WJ, Tsai TT, Shieh CC, Lin CF. Albumin prevents reactive oxygen species-induced mito-chondrial damage, autophagy, and apoptosis during serum starvation. Apoptosis 17: 1156-1169, 2012.
    • (2012) Apoptosis , vol.17 , pp. 1156-1169
    • Liu, S.Y.1    Chen, C.L.2    Yang, T.T.3    Huang, W.C.4    Hsieh, C.Y.5    Shen, W.J.6    Tsai, T.T.7    Shieh, C.C.8    Lin, C.F.9
  • 68
    • 79960623748 scopus 로고    scopus 로고
    • Understanding the role of growth factors in embryonic development: Insights from the lens
    • Lovicu FJ, McAvoy JW, de Iongh RU. Understanding the role of growth factors in embryonic development: insights from the lens. Philos Trans R Soc Lond B Biol Sci 366: 1204-1218, 2011.
    • (2011) Philos Trans R Soc Lond B Biol Sci , vol.366 , pp. 1204-1218
    • Lovicu, F.J.1    McAvoy, J.W.2    de Iongh, R.U.3
  • 69
    • 12944303650 scopus 로고    scopus 로고
    • Growth factor regulation of autophagy and cell survival in the absence of apoptosis
    • Lum JJ, Bauer DE, Kong M, Harris MH, Li C, Lindsten T, Thompson CB. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120: 237-248, 2005.
    • (2005) Cell , vol.120 , pp. 237-248
    • Lum, J.J.1    Bauer, D.E.2    Kong, M.3    Harris, M.H.4    Li, C.5    Lindsten, T.6    Thompson, C.B.7
  • 70
    • 34247631690 scopus 로고    scopus 로고
    • The transcription factor HIF-1alpha plays a critical role in the growth actor-dependent regulation of both aerobic and anaerobic glycolysis
    • Lum JJ, Bui T, Gruber M, Gordan JD, DeBerardinis RJ, Covello KL, Simon MC, Thompson CB. The transcription factor HIF-1alpha plays a critical role in the growth actor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev 21: 1037-1049, 2007.
    • (2007) Genes Dev , vol.21 , pp. 1037-1049
    • Lum, J.J.1    Bui, T.2    Gruber, M.3    Gordan, J.D.4    Deberardinis, R.J.5    Covello, K.L.6    Simon, M.C.7    Thompson, C.B.8
  • 73
    • 34548188741 scopus 로고    scopus 로고
    • Self-eating and self-killing: Crosstalk between au-tophagy and apoptosis
    • Maiuri MC, Zalckvar E, Kimchi A, Kroemer G. Self-eating and self-killing: crosstalk between au-tophagy and apoptosis. Nat Rev Mol Cell Biol 8: 741-752, 2007.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 741-752
    • Maiuri, M.C.1    Zalckvar, E.2    Kimchi, A.3    Kroemer, G.4
  • 75
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell 129: 1261-1274, 2007.
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 76
    • 0036342294 scopus 로고    scopus 로고
    • Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-ki-nase/Akt pathway
    • Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-ki-nase/Akt pathway. Mol Cell 10: 151-162, 2002.
    • (2002) Mol Cell , vol.10 , pp. 151-162
    • Manning, B.D.1    Tee, A.R.2    Logsdon, M.N.3    Blenis, J.4    Cantley, L.C.5
  • 77
    • 34547132328 scopus 로고    scopus 로고
    • Tissue-specific autophagy alterations and increased tumorigen-esis in mice deficient in Atg4C/autophagin-3
    • Mariño G, Salvador-Montoliu N, Fueyo A, Knecht E, Mizushima N, López-Otín C. Tissue-specific autophagy alterations and increased tumorigen-esis in mice deficient in Atg4C/autophagin-3. J Biol Chem 282: 18573-18583, 2007.
    • (2007) J Biol Chem , vol.282 , pp. 18573-18583
    • Mariño, G.1    Salvador-Montoliu, N.2    Fueyo, A.3    Knecht, E.4    Mizushima, N.5    López-Otín, C.6
  • 78
    • 33847652900 scopus 로고    scopus 로고
    • Autophagy and neurodegeneration: When the cleaning crew goes onstrike
    • Martinez-Vicente M, Cuervo AM. Autophagy and neurodegeneration: when the cleaning crew goes onstrike. Lancet Neurol 6: 352-361, 2007.
    • (2007) Lancet Neurol , vol.6 , pp. 352-361
    • Martinez-Vicente, M.1    Cuervo, A.M.2
  • 80
    • 84873521661 scopus 로고    scopus 로고
    • The role of autophagy in genome stability through suppression of abnormal mitosis under starvation
    • Matsui A, Kamada Y, Matsuura A. The role of autophagy in genome stability through suppression of abnormal mitosis under starvation. PLos Genet 9: e1003245, 2013.
    • (2013) PLos Genet , vol.9
    • Matsui, A.1    Kamada, Y.2    Matsuura, A.3
  • 82
    • 77954234752 scopus 로고    scopus 로고
    • Cytosolic FoxO1: Alive and killing
    • Medema RH, Jäättelä M. Cytosolic FoxO1: alive and killing. Nat Cell Biol 12: 642-643, 2010.
    • (2010) Nat Cell Biol , vol.12 , pp. 642-643
    • Medema, R.H.1    Jäättelä, M.2
  • 84
    • 79959999581 scopus 로고    scopus 로고
    • Microau-tophagy in mammalian cells: Revisiting a 40-year-old conundrum
    • Mijaljica D, Prescott M, Devenish RJ. Microau-tophagy in mammalian cells: revisiting a 40-year-old conundrum. Autophagy 7: 673-682, 2011.
    • (2011) Autophagy , vol.7 , pp. 673-682
    • Mijaljica, D.1    Prescott, M.2    Devenish, R.J.3
  • 85
    • 81055144784 scopus 로고    scopus 로고
    • Autophagy: Renovation of cells and tissues
    • Mizushima N, Komatsu M. Autophagy: renovation of cells and tissues. Cell 147: 728-741, 2011.
    • (2011) Cell , vol.147 , pp. 728-741
    • Mizushima, N.1    Komatsu, M.2
  • 87
    • 78751625682 scopus 로고    scopus 로고
    • Necrotizing enterocolitis
    • Neu J, Walker WA. Necrotizing enterocolitis. N Engl J Med 364: 255-264, 2011.
    • (2011) N Engl J Med , vol.364 , pp. 255-264
    • Neu, J.1    Walker, W.A.2
  • 91
    • 0032529189 scopus 로고    scopus 로고
    • Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor
    • Paradis S, Ruvkun G. Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev 12: 2488-2498, 1998.
    • (1998) Genes Dev , vol.12 , pp. 2488-2498
    • Paradis, S.1    Ruvkun, G.2
  • 92
    • 0036714127 scopus 로고    scopus 로고
    • Akt regulates growth by directly phosphorylating Tsc2
    • Potter CJ, Pedraza LG, Xu T. Akt regulates growth by directly phosphorylating Tsc2. Nat Cell Biol 4: 658-665, 2002.
    • (2002) Nat Cell Biol , vol.4 , pp. 658-665
    • Potter, C.J.1    Pedraza, L.G.2    Xu, T.3
  • 93
    • 78649704325 scopus 로고    scopus 로고
    • Autophagy, metabolism
    • Rabinowitz JD, White E. Autophagy, metabolism. Science 330: 1344-1348, 2010.
    • (2010) Science , vol.330 , pp. 1344-1348
    • Rabinowitz, J.D.1    White, E.2
  • 94
    • 0033635249 scopus 로고    scopus 로고
    • In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability
    • Rathmell JC, Vander Heiden MG, Harris MH, Frauwirth KA, Thompson CB. In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. Mol Cell 6: 683-692, 2000.
    • (2000) Mol Cell , vol.6 , pp. 683-692
    • Rathmell, J.C.1    Vander, H.M.G.2    Harris, M.H.3    Frauwirth, K.A.4    Thompson, C.B.5
  • 96
    • 70349246381 scopus 로고    scopus 로고
    • Regulation of amino acid transporters by glucose and growth factors in cultured primary human trophoblast cells is mediated by mTOR signaling
    • Roos S, Lagerlöf O, Wennergren M, Powell TL, Jansson T. Regulation of amino acid transporters by glucose and growth factors in cultured primary human trophoblast cells is mediated by mTOR signaling. Am J Physiol Cell Physiol 297: C723-C731, 2009.
    • (2009) Am J Physiol Cell Physiol , vol.297
    • Roos, S.1    Lagerlöf, O.2    Wennergren, M.3    Powell, T.L.4    Jansson, T.5
  • 101
    • 82255192465 scopus 로고    scopus 로고
    • Degradation of paternal mitochondria by fertilization-triggered autophagy in C. el-egans embryos
    • Sato M, Sato K. Degradation of paternal mitochondria by fertilization-triggered autophagy in C. el-egans embryos. Science 334: 1141-1144, 2011.
    • (2011) Science , vol.334 , pp. 1141-1144
    • Sato, M.1    Sato, K.2
  • 102
    • 84866601479 scopus 로고    scopus 로고
    • Regulation of metabolism by hy-poxia-inducible factor 1
    • Semenza GL. Regulation of metabolism by hy-poxia-inducible factor 1. Cold Spring Harb Symp Quant Biol 76: 347-353, 2011.
    • (2011) Cold Spring Harb Symp Quant Biol , vol.76 , pp. 347-353
    • Semenza, G.L.1
  • 103
    • 70350500068 scopus 로고    scopus 로고
    • FoxO transcription factors promote autophagy in cardiomy-ocytes
    • Sengupta A, Molkentin JD, Yutzey KE. FoxO transcription factors promote autophagy in cardiomy-ocytes. J Biol Chem 284: 28319-28331, 2009.
    • (2009) J Biol Chem , vol.284 , pp. 28319-28331
    • Sengupta, A.1    Molkentin, J.D.2    Yutzey, K.E.3
  • 104
    • 84856431622 scopus 로고    scopus 로고
    • The end of au-tophagic cell death?
    • Shen S, Kepp O, Kroemer G. The end of au-tophagic cell death? Autophagy 8: 1-3, 2012.
    • (2012) Autophagy , vol.8 , pp. 1-3
    • Shen, S.1    Kepp, O.2    Kroemer, G.3
  • 105
    • 0027070855 scopus 로고
    • Wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate
    • Siegfried E, Chou TB, Perrimon N. Wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate. Cell 71: 1167-1179, 1992.
    • (1992) Cell , vol.71 , pp. 1167-1179
    • Siegfried, E.1    Chou, T.B.2    Perrimon, N.3
  • 107
    • 84860217431 scopus 로고    scopus 로고
    • The functions and regulation of the PTEN tumour suppressor
    • Song MS, Salmena L, Pandolfi PP. The functions and regulation of the PTEN tumour suppressor. Nat Rev Mol Cell Biol 13: 283-296, 2012.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 283-296
    • Song, M.S.1    Salmena, L.2    Pandolfi, P.P.3
  • 109
    • 0026668042 scopus 로고
    • Autophagy in yeast demonstrated with protei-nase-deficient mutants and conditions for its induction
    • Takeshige K, Baba M, Tsuboi S, Noda T, Ohsumi Y. Autophagy in yeast demonstrated with protei-nase-deficient mutants and conditions for its induction. J Cell Biol 119: 301-311, 1992.
    • (1992) J Cell Biol , vol.119 , pp. 301-311
    • Takeshige, K.1    Baba, M.2    Tsuboi, S.3    Noda, T.4    Ohsumi, Y.5
  • 110
    • 1942424799 scopus 로고    scopus 로고
    • Inhibition of platelet-derived growth factor signaling induces autophagy in malignant glioma cells
    • Takeuchi H, Kanzawa T, Kondo Y, Kondo S. Inhibition of platelet-derived growth factor signaling induces autophagy in malignant glioma cells. Br J Cancer 90: 1069-1075, 2004.
    • (2004) Br J Cancer , vol.90 , pp. 1069-1075
    • Takeuchi, H.1    Kanzawa, T.2    Kondo, Y.3    Kondo, S.4
  • 111
    • 0035805180 scopus 로고    scopus 로고
    • The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation
    • Tapon N, Ito N, Dickson BJ, Treisman JE, Hari-haran IK. The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell 105: 345-355, 2001.
    • (2001) Cell , vol.105 , pp. 345-355
    • Tapon, N.1    Ito, N.2    Dickson, B.J.3    Treisman, J.E.4    Hari-Haran, I.K.5
  • 112
    • 84865293299 scopus 로고    scopus 로고
    • Autophagy inhibition in cancer therapy: Metabolic considerations for anti-tumor immunity
    • Townsend KN, Hughson LR, Schlie K, Poon VI, Westerback A, Lum JJ. Autophagy inhibition in cancer therapy: metabolic considerations for anti-tumor immunity. Immunol Rev 249: 176-194, 2012.
    • (2012) Immunol Rev , vol.249 , pp. 176-194
    • Townsend, K.N.1    Hughson, L.R.2    Schlie, K.3    Poon, V.I.4    Westerback, A.5    Lum, J.J.6
  • 115
    • 34249281690 scopus 로고    scopus 로고
    • Stressing the role of FoxO proteins in lifespan and disease
    • Van der Horst A, Burgering BM. Stressing the role of FoxO proteins in lifespan and disease. Nat Rev Mol Cell Biol 8: 440-450, 2007.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 440-450
    • Van der Horst, A.1    Burgering, B.M.2
  • 118
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324: 1029-1033, 2009.
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander, H.M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 119
  • 121
    • 84858604270 scopus 로고    scopus 로고
    • Metabolic reprogram-ming: A cancer hallmark even Warburg did not anticipate
    • Ward PS, Thompson CB. Metabolic reprogram-ming: a cancer hallmark even Warburg did not anticipate. Cancer Cell 21: 297-308, 2012.
    • (2012) Cancer Cell , vol.21 , pp. 297-308
    • Ward, P.S.1    Thompson, C.B.2
  • 125
    • 78649391422 scopus 로고    scopus 로고
    • Cellular metabolic stress: Considering how cells respond to nutrient excess
    • Wellen KE, Thompson CB. Cellular metabolic stress: considering how cells respond to nutrient excess. Mol Cell 40: 323-332, 2010.
    • (2010) Mol Cell , vol.40 , pp. 323-332
    • Wellen, K.E.1    Thompson, C.B.2
  • 126
    • 0038676258 scopus 로고    scopus 로고
    • Regulation of wound healing by growth factors and cytokines
    • Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiol Rev 83: 835-870, 2003.
    • (2003) Physiol Rev , vol.83 , pp. 835-870
    • Werner, S.1    Grose, R.2
  • 127
    • 84861526009 scopus 로고    scopus 로고
    • Deconvoluting the context-dependent role for autophagy in cancer
    • White E. Deconvoluting the context-dependent role for autophagy in cancer. Nat Rev Cancer 12: 401-410, 2012.
    • (2012) Nat Rev Cancer , vol.12 , pp. 401-410
    • White, E.1
  • 128
    • 77951967101 scopus 로고    scopus 로고
    • Roles for growth factors in cancer progression
    • Witsch E, Sela M, Yarden Y. Roles for growth factors in cancer progression. Physiology 25: 85-101, 2010.
    • (2010) Physiology , vol.25 , pp. 85-101
    • Witsch, E.1    Sela, M.2    Yarden, Y.3
  • 129
    • 77954116814 scopus 로고    scopus 로고
    • Autophagy gone awry in neurodegenerative diseases
    • Wong E, Cuervo AM. Autophagy gone awry in neurodegenerative diseases. Nat Neurosci 13: 805-811, 2010.
    • (2010) Nat Neurosci , vol.13 , pp. 805-811
    • Wong, E.1    Cuervo, A.M.2
  • 130
    • 0035921728 scopus 로고    scopus 로고
    • The tyrosine phosphatase SHP-2 is required for mediating phosphatidylino-sitol 3-kinase/Akt activation by growth factors
    • Wu CJ, O'Rourke DM, Feng GS, Johnson GR, Wang Q, Greene MI. The tyrosine phosphatase SHP-2 is required for mediating phosphatidylino-sitol 3-kinase/Akt activation by growth factors. Oncogene 20: 6018-6025, 2001.
    • (2001) Oncogene , vol.20 , pp. 6018-6025
    • Wu, C.J.1    O'Rourke, D.M.2    Feng, G.S.3    Johnson, G.R.4    Wang, Q.5    Greene, M.I.6
  • 131
    • 77649129121 scopus 로고    scopus 로고
    • GSK3: A multifaceted kinase in Wnt signaling
    • Wu D, Pan W. GSK3: a multifaceted kinase in Wnt signaling. Trends Biochem Sci 35: 161-168, 2010.
    • (2010) Trends Biochem Sci , vol.35 , pp. 161-168
    • Wu, D.1    Pan, W.2
  • 132
    • 34848886914 scopus 로고    scopus 로고
    • Autophagosome formation: Core machinery and adaptations
    • Xie Z, Klionsky DJ. Autophagosome formation: core machinery and adaptations. Nat Cell Biol 9: 1102, 2007.
    • (2007) Nat Cell Biol , vol.9 , pp. 1102
    • Xie, Z.1    Klionsky, D.J.2
  • 134
    • 77956404377 scopus 로고    scopus 로고
    • Eaten alive: A history of mac-roautophagy
    • Yang Z, Klionsky DJ. Eaten alive: a history of mac-roautophagy. Nat Cell Biol 12: 814-822, 2010.
    • (2010) Nat Cell Biol , vol.12 , pp. 814-822
    • Yang, Z.1    Klionsky, D.J.2
  • 135
    • 77951214016 scopus 로고    scopus 로고
    • The autophagy core machinery mammalian autophagy: Core molecular machinery and signaling regulation
    • Yang Z, Klionsky DJ. The autophagy core machinery mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol 22: 124-131, 2010.
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 124-131
    • Yang, Z.1    Klionsky, D.J.2
  • 136
    • 0035937767 scopus 로고    scopus 로고
    • A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mito-gen-activated protein kinases by epidermal growth factor
    • Yart A, Laffargue M, Mayeux P, Chretien S, Peres C, Tonks N, Roche S, Payrastre B, Chap H, Raynal P. A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mito-gen-activated protein kinases by epidermal growth factor. J Biol Chem 276: 8856-8864, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 8856-8864
    • Yart, A.1    Laffargue, M.2    Mayeux, P.3    Chretien, S.4    Peres, C.5    Tonks, N.6    Roche, S.7    Payrastre, B.8    Chap, H.9    Raynal, P.10
  • 138
    • 78649901091 scopus 로고    scopus 로고
    • Alternative cell death mechanisms in development and beyond
    • Yuan J, Kroemer G. Alternative cell death mechanisms in development and beyond. Genes Dev 24: 2592-2602, 2010.
    • (2010) Genes Dev , vol.24 , pp. 2592-2602
    • Yuan, J.1    Kroemer, G.2
  • 139
    • 51849111556 scopus 로고    scopus 로고
    • PI3K pathway alterations in cancer: Variations on a theme
    • Yuan TL, Cantley LC. PI3K pathway alterations in cancer: variations on a theme. Oncogene 27: 5497-5510, 2008.
    • (2008) Oncogene , vol.27 , pp. 5497-5510
    • Yuan, T.L.1    Cantley, L.C.2
  • 140
    • 0345166111 scopus 로고    scopus 로고
    • Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
    • Yue Z, Jin S, Yang C, Levine AJ, Heintz N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA 100: 15077-15082, 2003.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 15077-15082
    • Yue, Z.1    Jin, S.2    Yang, C.3    Levine, A.J.4    Heintz, N.5
  • 141
    • 73949124173 scopus 로고    scopus 로고
    • Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis
    • Zhang Y, Goldman S, Baerga R, Zhao Y, Komatsu M, Jin S. Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis. Proc Natl Acad Sci USA 106: 19860-19865, 2009.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 19860-19865
    • Zhang, Y.1    Goldman, S.2    Baerga, R.3    Zhao, Y.4    Komatsu, M.5    Jin, S.6
  • 143
    • 36448968532 scopus 로고    scopus 로고
    • FoxO3 coordinately activates protein degradation by the autophagic/ lysosomal and proteasomal pathways in atrophying muscle cells
    • Zhao J, Brault JJ, Schild A, Cao P, Sandri M, Schiaffino S, Lecker SH, Goldberg AL. FoxO3 coordinately activates protein degradation by the autophagic/ lysosomal and proteasomal pathways in atrophying muscle cells. Cell Metab 6: 472-483, 2007.
    • (2007) Cell Metab , vol.6 , pp. 472-483
    • Zhao, J.1    Brault, J.J.2    Schild, A.3    Cao, P.4    Sandri, M.5    Schiaffino, S.6    Lecker, S.H.7    Goldberg, A.L.8
  • 146
    • 84876408458 scopus 로고    scopus 로고
    • Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion
    • Zhou J, Tan SH, Nicolas V, Bauvy C, Yang ND, Zhang J, Xue Y, Codogno P, Shen HM. Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion. Cell Res 23: 508-523, 2013.
    • (2013) Cell Res , vol.23 , pp. 508-523
    • Zhou, J.1    Tan, S.H.2    Nicolas, V.3    Bauvy, C.4    Yang, N.D.5    Zhang, J.6    Xue, Y.7    Codogno, P.8    Shen, H.M.9
  • 147
    • 78650510609 scopus 로고    scopus 로고
    • mTOR: From growth signal integration to cancer, diabetes and ageing
    • Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 12: 21-35, 2011.
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3


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