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Volumn 40, Issue 2, 2010, Pages 323-332

Cellular Metabolic Stress: Considering How Cells Respond to Nutrient Excess

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; MAMMALIAN TARGET OF RAPAMYCIN; REACTIVE OXYGEN METABOLITE;

EID: 78649391422     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2010.10.004     Document Type: Review
Times cited : (401)

References (109)
  • 2
    • 34250745912 scopus 로고    scopus 로고
    • The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production
    • Bell E.L., Klimova T.A., Eisenbart J., Moraes C.T., Murphy M.P., Budinger G.R., Chandel N.S. The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production. J. Cell Biol. 2007, 177:1029-1036.
    • (2007) J. Cell Biol. , vol.177 , pp. 1029-1036
    • Bell, E.L.1    Klimova, T.A.2    Eisenbart, J.3    Moraes, C.T.4    Murphy, M.P.5    Budinger, G.R.6    Chandel, N.S.7
  • 5
    • 33746466098 scopus 로고    scopus 로고
    • Mitochondrial mutations in cancer
    • Brandon M., Baldi P., Wallace D.C. Mitochondrial mutations in cancer. Oncogene 2006, 25:4647-4662.
    • (2006) Oncogene , vol.25 , pp. 4647-4662
    • Brandon, M.1    Baldi, P.2    Wallace, D.C.3
  • 7
    • 78649357985 scopus 로고    scopus 로고
    • Protein quality control in the cytosol and the Endoplasmic Reticulum: Brothers in Arms
    • this issue
    • Buchberger A., Bukau B., Sommer T. Protein quality control in the cytosol and the Endoplasmic Reticulum: Brothers in Arms. Mol. Cell 2010, 40:238-252. this issue.
    • (2010) Mol. Cell , vol.40 , pp. 238-252
    • Buchberger, A.1    Bukau, B.2    Sommer, T.3
  • 8
    • 77952429792 scopus 로고    scopus 로고
    • Nutrient sensor O-GlcNAc transferase regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1
    • Caldwell S.A., Jackson S.R., Shahriari K.S., Lynch T.P., Sethi G., Walker S., Vosseller K., Reginato M.J. Nutrient sensor O-GlcNAc transferase regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1. Oncogene 2010, 29:2831-2842.
    • (2010) Oncogene , vol.29 , pp. 2831-2842
    • Caldwell, S.A.1    Jackson, S.R.2    Shahriari, K.S.3    Lynch, T.P.4    Sethi, G.5    Walker, S.6    Vosseller, K.7    Reginato, M.J.8
  • 9
    • 3543072186 scopus 로고    scopus 로고
    • Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms
    • Calle E.E., Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat. Rev. Cancer 2004, 4:579-591.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 579-591
    • Calle, E.E.1    Kaaks, R.2
  • 10
    • 34447339656 scopus 로고    scopus 로고
    • Mgat5 and Pten interact to regulate cell growth and polarity
    • Cheung P., Dennis J.W. Mgat5 and Pten interact to regulate cell growth and polarity. Glycobiology 2007, 17:767-773.
    • (2007) Glycobiology , vol.17 , pp. 767-773
    • Cheung, P.1    Dennis, J.W.2
  • 11
    • 34547769859 scopus 로고    scopus 로고
    • Metabolic homeostasis and tissue renewal are dependent on beta1,6GlcNAc-branched N-glycans
    • Cheung P., Pawling J., Partridge E.A., Sukhu B., Grynpas M., Dennis J.W. Metabolic homeostasis and tissue renewal are dependent on beta1,6GlcNAc-branched N-glycans. Glycobiology 2007, 17:828-837.
    • (2007) Glycobiology , vol.17 , pp. 828-837
    • Cheung, P.1    Pawling, J.2    Partridge, E.A.3    Sukhu, B.4    Grynpas, M.5    Dennis, J.W.6
  • 12
    • 0029049198 scopus 로고
    • C-Myc is glycosylated at threonine 58, a known phosphorylation site and a mutational hot spot in lymphomas
    • Chou T.Y., Hart G.W., Dang C.V. c-Myc is glycosylated at threonine 58, a known phosphorylation site and a mutational hot spot in lymphomas. J. Biol. Chem. 1995, 270:18961-18965.
    • (1995) J. Biol. Chem. , vol.270 , pp. 18961-18965
    • Chou, T.Y.1    Hart, G.W.2    Dang, C.V.3
  • 15
    • 67650151005 scopus 로고    scopus 로고
    • Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability
    • Colotta F., Allavena P., Sica A., Garlanda C., Mantovani A. Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis 2009, 30:1073-1081.
    • (2009) Carcinogenesis , vol.30 , pp. 1073-1081
    • Colotta, F.1    Allavena, P.2    Sica, A.3    Garlanda, C.4    Mantovani, A.5
  • 16
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens L.M., Werb Z. Inflammation and cancer. Nature 2002, 420:860-867.
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 17
    • 29244462498 scopus 로고    scopus 로고
    • Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway
    • Cullinan S.B., Diehl J.A. Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway. Int. J. Biochem. Cell Biol. 2006, 38:317-332.
    • (2006) Int. J. Biochem. Cell Biol. , vol.38 , pp. 317-332
    • Cullinan, S.B.1    Diehl, J.A.2
  • 18
    • 49849093007 scopus 로고    scopus 로고
    • Unravelling the tumor-suppressive functions of FOXO proteins
    • Dansen T.B., Burgering B.M. Unravelling the tumor-suppressive functions of FOXO proteins. Trends Cell Biol. 2008, 18:421-429.
    • (2008) Trends Cell Biol. , vol.18 , pp. 421-429
    • Dansen, T.B.1    Burgering, B.M.2
  • 19
    • 37449034854 scopus 로고    scopus 로고
    • Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
    • DeBerardinis R.J., Mancuso A., Daikhin E., Nissim I., Yudkoff M., Wehrli S., Thompson C.B. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc. Natl. Acad. Sci. USA 2007, 104:19345-19350.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 19345-19350
    • DeBerardinis, R.J.1    Mancuso, A.2    Daikhin, E.3    Nissim, I.4    Yudkoff, M.5    Wehrli, S.6    Thompson, C.B.7
  • 20
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
    • DeBerardinis R.J., Lum J.J., Hatzivassiliou G., Thompson C.B. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab. 2008, 7:11-20.
    • (2008) Cell Metab. , vol.7 , pp. 11-20
    • DeBerardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 21
    • 72249094196 scopus 로고    scopus 로고
    • Metabolism, cell surface organization, and disease
    • Dennis J.W., Nabi I.R., Demetriou M. Metabolism, cell surface organization, and disease. Cell 2009, 139:1229-1241.
    • (2009) Cell , vol.139 , pp. 1229-1241
    • Dennis, J.W.1    Nabi, I.R.2    Demetriou, M.3
  • 22
    • 0036320205 scopus 로고    scopus 로고
    • Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake
    • Edinger A.L., Thompson C.B. Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake. Mol. Biol. Cell 2002, 13:2276-2288.
    • (2002) Mol. Biol. Cell , vol.13 , pp. 2276-2288
    • Edinger, A.L.1    Thompson, C.B.2
  • 24
    • 47549098593 scopus 로고    scopus 로고
    • The role of Nrf2 in increased reactive oxygen species and DNA damage in prostate tumorigenesis
    • Frohlich D.A., McCabe M.T., Arnold R.S., Day M.L. The role of Nrf2 in increased reactive oxygen species and DNA damage in prostate tumorigenesis. Oncogene 2008, 27:4353-4362.
    • (2008) Oncogene , vol.27 , pp. 4353-4362
    • Frohlich, D.A.1    McCabe, M.T.2    Arnold, R.S.3    Day, M.L.4
  • 25
    • 77957241580 scopus 로고    scopus 로고
    • The proliferating role of insulin and insulin-like growth factors in cancer
    • Gallagher E.J., Leroith D. The proliferating role of insulin and insulin-like growth factors in cancer. Trends Endocrinol. Metab. 2010, 21:610-618.
    • (2010) Trends Endocrinol. Metab. , vol.21 , pp. 610-618
    • Gallagher, E.J.1    Leroith, D.2
  • 28
    • 33750523632 scopus 로고    scopus 로고
    • NF-kappaB activation by reactive oxygen species: fifteen years later
    • Gloire G., Legrand-Poels S., Piette J. NF-kappaB activation by reactive oxygen species: fifteen years later. Biochem. Pharmacol. 2006, 72:1493-1505.
    • (2006) Biochem. Pharmacol. , vol.72 , pp. 1493-1505
    • Gloire, G.1    Legrand-Poels, S.2    Piette, J.3
  • 29
    • 12744279326 scopus 로고    scopus 로고
    • Redox paradox: insulin action is facilitated by insulin-stimulated reactive oxygen species with multiple potential signaling targets
    • Goldstein B.J., Mahadev K., Kalyankar M., Wu X. Redox paradox: insulin action is facilitated by insulin-stimulated reactive oxygen species with multiple potential signaling targets. Diabetes 2005, 54:311-321.
    • (2005) Diabetes , vol.54 , pp. 311-321
    • Goldstein, B.J.1    Mahadev, K.2    Kalyankar, M.3    Wu, X.4
  • 31
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • Grivennikov S.I., Greten F.R., Karin M. Immunity, inflammation, and cancer. Cell 2010, 140:883-899.
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 33
    • 33747596652 scopus 로고    scopus 로고
    • Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia
    • Guzy R.D., Schumacker P.T. Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia. Exp. Physiol. 2006, 91:807-819.
    • (2006) Exp. Physiol. , vol.91 , pp. 807-819
    • Guzy, R.D.1    Schumacker, P.T.2
  • 35
    • 77949887506 scopus 로고    scopus 로고
    • Mammalian sirtuins: biological insights and disease relevance
    • Haigis M.C., Sinclair D.A. Mammalian sirtuins: biological insights and disease relevance. Annu. Rev. Pathol. 2010, 5:253-295.
    • (2010) Annu. Rev. Pathol. , vol.5 , pp. 253-295
    • Haigis, M.C.1    Sinclair, D.A.2
  • 36
    • 33846331650 scopus 로고    scopus 로고
    • Oxidative stress and cancer: have we moved forward?
    • Halliwell B. Oxidative stress and cancer: have we moved forward?. Biochem. J. 2007, 401:1-11.
    • (2007) Biochem. J. , vol.401 , pp. 1-11
    • Halliwell, B.1
  • 37
    • 77956186783 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes
    • Hamanaka R.B., Chandel N.S. Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes. Trends Biochem. Sci. 2010, 35:505-513.
    • (2010) Trends Biochem. Sci. , vol.35 , pp. 505-513
    • Hamanaka, R.B.1    Chandel, N.S.2
  • 40
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil G.S. Inflammation and metabolic disorders. Nature 2006, 444:860-867.
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 41
    • 77950343252 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
    • Hotamisligil G.S. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 2010, 140:900-917.
    • (2010) Cell , vol.140 , pp. 900-917
    • Hotamisligil, G.S.1
  • 42
    • 33645860825 scopus 로고    scopus 로고
    • Reactive oxygen species have a causal role in multiple forms of insulin resistance
    • Houstis N., Rosen E.D., Lander E.S. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 2006, 440:944-948.
    • (2006) Nature , vol.440 , pp. 944-948
    • Houstis, N.1    Rosen, E.D.2    Lander, E.S.3
  • 45
    • 64749108996 scopus 로고    scopus 로고
    • Tumours with PI3K activation are resistant to dietary restriction
    • Kalaany N.Y., Sabatini D.M. Tumours with PI3K activation are resistant to dietary restriction. Nature 2009, 458:725-731.
    • (2009) Nature , vol.458 , pp. 725-731
    • Kalaany, N.Y.1    Sabatini, D.M.2
  • 46
    • 14844327760 scopus 로고    scopus 로고
    • Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases
    • Kamata H., Honda S., Maeda S., Chang L., Hirata H., Karin M. Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 2005, 120:649-661.
    • (2005) Cell , vol.120 , pp. 649-661
    • Kamata, H.1    Honda, S.2    Maeda, S.3    Chang, L.4    Hirata, H.5    Karin, M.6
  • 47
    • 25844459154 scopus 로고    scopus 로고
    • NF-kappaB: linking inflammation and immunity to cancer development and progression
    • Karin M., Greten F.R. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat. Rev. Immunol. 2005, 5:749-759.
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 749-759
    • Karin, M.1    Greten, F.R.2
  • 50
    • 0021891884 scopus 로고
    • Assembly of asparagine-linked oligosaccharides
    • Kornfeld R., Kornfeld S. Assembly of asparagine-linked oligosaccharides. Annu. Rev. Biochem. 1985, 54:631-664.
    • (1985) Annu. Rev. Biochem. , vol.54 , pp. 631-664
    • Kornfeld, R.1    Kornfeld, S.2
  • 51
    • 53049084874 scopus 로고    scopus 로고
    • N-Glycans in cancer progression
    • Lau K.S., Dennis J.W. N-Glycans in cancer progression. Glycobiology 2008, 18:750-760.
    • (2008) Glycobiology , vol.18 , pp. 750-760
    • Lau, K.S.1    Dennis, J.W.2
  • 52
    • 33947724303 scopus 로고    scopus 로고
    • Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation
    • Lau K.S., Partridge E.A., Grigorian A., Silvescu C.I., Reinhold V.N., Demetriou M., Dennis J.W. Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation. Cell 2007, 129:123-134.
    • (2007) Cell , vol.129 , pp. 123-134
    • Lau, K.S.1    Partridge, E.A.2    Grigorian, A.3    Silvescu, C.I.4    Reinhold, V.N.5    Demetriou, M.6    Dennis, J.W.7
  • 53
    • 34248571826 scopus 로고    scopus 로고
    • GRP78 induction in cancer: therapeutic and prognostic implications
    • Lee A.S. GRP78 induction in cancer: therapeutic and prognostic implications. Cancer Res. 2007, 67:3496-3499.
    • (2007) Cancer Res. , vol.67 , pp. 3496-3499
    • Lee, A.S.1
  • 57
    • 33644874204 scopus 로고    scopus 로고
    • The hexosamine signaling pathway: deciphering the " O-GlcNAc code"
    • Love D.C., Hanover J.A. The hexosamine signaling pathway: deciphering the " O-GlcNAc code" Sci. STKE 2005, 2005:re13.
    • (2005) Sci. STKE , vol.2005
    • Love, D.C.1    Hanover, J.A.2
  • 58
    • 78649364332 scopus 로고    scopus 로고
    • Hypoxia inducible factors and the response to hypoxic stress
    • this issue
    • Majmundar A., Wong W.J., Simon M.C. Hypoxia inducible factors and the response to hypoxic stress. Mol. Cell 2010, 40:294-309. this issue.
    • (2010) Mol. Cell , vol.40 , pp. 294-309
    • Majmundar, A.1    Wong, W.J.2    Simon, M.C.3
  • 59
    • 24144447915 scopus 로고    scopus 로고
    • Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation
    • Mansfield K.D., Guzy R.D., Pan Y., Young R.M., Cash T.P., Schumacker P.T., Simon M.C. Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation. Cell Metab. 2005, 1:393-399.
    • (2005) Cell Metab. , vol.1 , pp. 393-399
    • Mansfield, K.D.1    Guzy, R.D.2    Pan, Y.3    Young, R.M.4    Cash, T.P.5    Schumacker, P.T.6    Simon, M.C.7
  • 61
    • 33750684953 scopus 로고    scopus 로고
    • Role of insulin, adipocyte hormones, and nutrient-sensing pathways in regulating fuel metabolism and energy homeostasis: a nutritional perspective of diabetes, obesity, and cancer
    • Marshall S. Role of insulin, adipocyte hormones, and nutrient-sensing pathways in regulating fuel metabolism and energy homeostasis: a nutritional perspective of diabetes, obesity, and cancer. Sci. STKE 2006, 2006:re7.
    • (2006) Sci. STKE , vol.2006
    • Marshall, S.1
  • 62
    • 0025855139 scopus 로고
    • Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance
    • Marshall S., Bacote V., Traxinger R.R. Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance. J. Biol. Chem. 1991, 266:4706-4712.
    • (1991) J. Biol. Chem. , vol.266 , pp. 4706-4712
    • Marshall, S.1    Bacote, V.2    Traxinger, R.R.3
  • 63
    • 0036184190 scopus 로고    scopus 로고
    • Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo
    • Meng T.C., Fukada T., Tonks N.K. Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo. Mol. Cell 2002, 9:387-399.
    • (2002) Mol. Cell , vol.9 , pp. 387-399
    • Meng, T.C.1    Fukada, T.2    Tonks, N.K.3
  • 64
    • 36348943088 scopus 로고    scopus 로고
    • Integrated endoplasmic reticulum stress responses in cancer
    • Moenner M., Pluquet O., Bouchecareilh M., Chevet E. Integrated endoplasmic reticulum stress responses in cancer. Cancer Res. 2007, 67:10631-10634.
    • (2007) Cancer Res. , vol.67 , pp. 10631-10634
    • Moenner, M.1    Pluquet, O.2    Bouchecareilh, M.3    Chevet, E.4
  • 65
    • 67650417891 scopus 로고    scopus 로고
    • C-Myc activates multiple metabolic networks to generate substrates for cell-cycle entry
    • Morrish F., Isern N., Sadilek M., Jeffrey M., Hockenbery D.M. c-Myc activates multiple metabolic networks to generate substrates for cell-cycle entry. Oncogene 2009, 28:2485-2491.
    • (2009) Oncogene , vol.28 , pp. 2485-2491
    • Morrish, F.1    Isern, N.2    Sadilek, M.3    Jeffrey, M.4    Hockenbery, D.M.5
  • 66
    • 58249093939 scopus 로고    scopus 로고
    • How mitochondria produce reactive oxygen species
    • Murphy M.P. How mitochondria produce reactive oxygen species. Biochem. J. 2009, 417:1-13.
    • (2009) Biochem. J. , vol.417 , pp. 1-13
    • Murphy, M.P.1
  • 67
    • 48149091097 scopus 로고    scopus 로고
    • Epidemic inflammation: pondering obesity
    • Nathan C. Epidemic inflammation: pondering obesity. Mol. Med. 2008, 14:485-492.
    • (2008) Mol. Med. , vol.14 , pp. 485-492
    • Nathan, C.1
  • 69
    • 56849118516 scopus 로고    scopus 로고
    • Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis
    • Nogueira V., Park Y., Chen C.C., Xu P.Z., Chen M.L., Tonic I., Unterman T., Hay N. Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. Cancer Cell 2008, 14:458-470.
    • (2008) Cancer Cell , vol.14 , pp. 458-470
    • Nogueira, V.1    Park, Y.2    Chen, C.C.3    Xu, P.Z.4    Chen, M.L.5    Tonic, I.6    Unterman, T.7    Hay, N.8
  • 71
    • 0842347416 scopus 로고    scopus 로고
    • Ogt-dependent X-chromosome-linked protein glycosylation is a requisite modification in somatic cell function and embryo viability
    • O'Donnell N., Zachara N.E., Hart G.W., Marth J.D. Ogt-dependent X-chromosome-linked protein glycosylation is a requisite modification in somatic cell function and embryo viability. Mol. Cell. Biol. 2004, 24:1680-1690.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 1680-1690
    • O'Donnell, N.1    Zachara, N.E.2    Hart, G.W.3    Marth, J.D.4
  • 72
    • 29244449332 scopus 로고    scopus 로고
    • Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes
    • Ohtsubo K., Takamatsu S., Minowa M.T., Yoshida A., Takeuchi M., Marth J.D. Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes. Cell 2005, 123:1307-1321.
    • (2005) Cell , vol.123 , pp. 1307-1321
    • Ohtsubo, K.1    Takamatsu, S.2    Minowa, M.T.3    Yoshida, A.4    Takeuchi, M.5    Marth, J.D.6
  • 73
    • 74549167737 scopus 로고    scopus 로고
    • Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression
    • Park E.J., Lee J.H., Yu G.Y., He G., Ali S.R., Holzer R.G., Osterreicher C.H., Takahashi H., Karin M. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 2010, 140:197-208.
    • (2010) Cell , vol.140 , pp. 197-208
    • Park, E.J.1    Lee, J.H.2    Yu, G.Y.3    He, G.4    Ali, S.R.5    Holzer, R.G.6    Osterreicher, C.H.7    Takahashi, H.8    Karin, M.9
  • 76
    • 77955619986 scopus 로고    scopus 로고
    • Proline metabolism and microenvironmental stress
    • Phang J.M., Liu W., Zabirnyk O. Proline metabolism and microenvironmental stress. Annu. Rev. Nutr. 2010, 30:441-463.
    • (2010) Annu. Rev. Nutr. , vol.30 , pp. 441-463
    • Phang, J.M.1    Liu, W.2    Zabirnyk, O.3
  • 78
    • 67349091737 scopus 로고    scopus 로고
    • Oxidative stress and metabolic syndrome
    • Roberts C.K., Sindhu K.K. Oxidative stress and metabolic syndrome. Life Sci. 2009, 84:705-712.
    • (2009) Life Sci. , vol.84 , pp. 705-712
    • Roberts, C.K.1    Sindhu, K.K.2
  • 80
    • 70450239457 scopus 로고    scopus 로고
    • Metabolism and cancer: the circadian clock connection
    • Sahar S., Sassone-Corsi P. Metabolism and cancer: the circadian clock connection. Nat. Rev. Cancer 2009, 9:886-896.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 886-896
    • Sahar, S.1    Sassone-Corsi, P.2
  • 81
    • 33748752151 scopus 로고    scopus 로고
    • The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity
    • Schieke S.M., Phillips D., McCoy J.P., Aponte A.M., Shen R.F., Balaban R.S., Finkel T. The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity. J. Biol. Chem. 2006, 281:27643-27652.
    • (2006) J. Biol. Chem. , vol.281 , pp. 27643-27652
    • Schieke, S.M.1    Phillips, D.2    McCoy, J.P.3    Aponte, A.M.4    Shen, R.F.5    Balaban, R.S.6    Finkel, T.7
  • 82
    • 38649123072 scopus 로고    scopus 로고
    • Conserved metabolic regulatory functions of sirtuins
    • Schwer B., Verdin E. Conserved metabolic regulatory functions of sirtuins. Cell Metab. 2008, 7:104-112.
    • (2008) Cell Metab. , vol.7 , pp. 104-112
    • Schwer, B.1    Verdin, E.2
  • 83
    • 0029984062 scopus 로고    scopus 로고
    • Antioxidant and redox regulation of gene transcription
    • Sen C.K., Packer L. Antioxidant and redox regulation of gene transcription. FASEB J. 1996, 10:709-720.
    • (1996) FASEB J. , vol.10 , pp. 709-720
    • Sen, C.K.1    Packer, L.2
  • 84
    • 78649348967 scopus 로고    scopus 로고
    • Regulation of the mTor complex 1 by nutrients, growth factors and stress
    • this issue
    • Sengupta S., Peterson T.R., Sabatini D.M. Regulation of the mTor complex 1 by nutrients, growth factors and stress. Mol. Cell 2010, 40:310-322. this issue.
    • (2010) Mol. Cell , vol.40 , pp. 310-322
    • Sengupta, S.1    Peterson, T.R.2    Sabatini, D.M.3
  • 85
    • 0034705030 scopus 로고    scopus 로고
    • The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny
    • Shafi R., Iyer S.P., Ellies L.G., O'Donnell N., Marek K.W., Chui D., Hart G.W., Marth J.D. The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny. Proc. Natl. Acad. Sci. USA 2000, 97:5735-5739.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 5735-5739
    • Shafi, R.1    Iyer, S.P.2    Ellies, L.G.3    O'Donnell, N.4    Marek, K.W.5    Chui, D.6    Hart, G.W.7    Marth, J.D.8
  • 88
    • 25444501339 scopus 로고    scopus 로고
    • Perturbations in O-linked beta-N-acetylglucosamine protein modification cause severe defects in mitotic progression and cytokinesis
    • Slawson C., Zachara N.E., Vosseller K., Cheung W.D., Lane M.D., Hart G.W. Perturbations in O-linked beta-N-acetylglucosamine protein modification cause severe defects in mitotic progression and cytokinesis. J. Biol. Chem. 2005, 280:32944-32956.
    • (2005) J. Biol. Chem. , vol.280 , pp. 32944-32956
    • Slawson, C.1    Zachara, N.E.2    Vosseller, K.3    Cheung, W.D.4    Lane, M.D.5    Hart, G.W.6
  • 89
    • 77956396629 scopus 로고    scopus 로고
    • O-GlcNAc signaling: a metabolic link between diabetes and cancer?
    • Slawson C., Copeland R.J., Hart G.W. O-GlcNAc signaling: a metabolic link between diabetes and cancer?. Trends Biochem. Sci. 2010, 35:547-555.
    • (2010) Trends Biochem. Sci. , vol.35 , pp. 547-555
    • Slawson, C.1    Copeland, R.J.2    Hart, G.W.3
  • 90
    • 76749097118 scopus 로고    scopus 로고
    • Hexosamine flux, the O-GlcNAc modification, and the development of insulin resistance in adipocytes
    • Teo C.F., Wollaston-Hayden E.E., Wells L. Hexosamine flux, the O-GlcNAc modification, and the development of insulin resistance in adipocytes. Mol. Cell. Endocrinol. 2010, 318:44-53.
    • (2010) Mol. Cell. Endocrinol. , vol.318 , pp. 44-53
    • Teo, C.F.1    Wollaston-Hayden, E.E.2    Wells, L.3
  • 92
    • 67650071137 scopus 로고    scopus 로고
    • Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
    • Trachootham D., Alexandre J., Huang P. Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?. Nat. Rev. Drug Discov. 2009, 8:579-591.
    • (2009) Nat. Rev. Drug Discov. , vol.8 , pp. 579-591
    • Trachootham, D.1    Alexandre, J.2    Huang, P.3
  • 93
    • 27944487902 scopus 로고    scopus 로고
    • Logic of the yeast metabolic cycle: temporal compartmentalization of cellular processes
    • Tu B.P., Kudlicki A., Rowicka M., McKnight S.L. Logic of the yeast metabolic cycle: temporal compartmentalization of cellular processes. Science 2005, 310:1152-1158.
    • (2005) Science , vol.310 , pp. 1152-1158
    • Tu, B.P.1    Kudlicki, A.2    Rowicka, M.3    McKnight, S.L.4
  • 94
    • 0142150051 scopus 로고    scopus 로고
    • Mitochondrial formation of reactive oxygen species
    • Turrens J.F. Mitochondrial formation of reactive oxygen species. J. Physiol. 2003, 552:335-344.
    • (2003) J. Physiol. , vol.552 , pp. 335-344
    • Turrens, J.F.1
  • 95
    • 34147210988 scopus 로고    scopus 로고
    • Hydrogen peroxide sensing and signaling
    • Veal E.A., Day A.M., Morgan B.A. Hydrogen peroxide sensing and signaling. Mol. Cell 2007, 26:1-14.
    • (2007) Mol. Cell , vol.26 , pp. 1-14
    • Veal, E.A.1    Day, A.M.2    Morgan, B.A.3
  • 96
    • 23844558266 scopus 로고    scopus 로고
    • A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine
    • Wallace D.C. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu. Rev. Genet. 2005, 39:359-407.
    • (2005) Annu. Rev. Genet. , vol.39 , pp. 359-407
    • Wallace, D.C.1
  • 97
    • 77149120797 scopus 로고    scopus 로고
    • Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux
    • Wang Q., Zhang Y., Yang C., Xiong H., Lin Y., Yao J., Li H., Xie L., Zhao W., Yao Y., et al. Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science 2010, 327:1004-1007.
    • (2010) Science , vol.327 , pp. 1004-1007
    • Wang, Q.1    Zhang, Y.2    Yang, C.3    Xiong, H.4    Lin, Y.5    Yao, J.6    Li, H.7    Xie, L.8    Zhao, W.9    Yao, Y.10
  • 100
  • 102
    • 52049120841 scopus 로고    scopus 로고
    • Regulation of the O-linked beta-N-acetylglucosamine transferase by insulin signaling
    • Whelan S.A., Lane M.D., Hart G.W. Regulation of the O-linked beta-N-acetylglucosamine transferase by insulin signaling. J. Biol. Chem. 2008, 283:21411-21417.
    • (2008) J. Biol. Chem. , vol.283 , pp. 21411-21417
    • Whelan, S.A.1    Lane, M.D.2    Hart, G.W.3
  • 103
    • 77949332132 scopus 로고    scopus 로고
    • Regulation of insulin receptor substrate 1 (IRS-1)/AKT kinase-mediated insulin signaling by O-Linked beta-N-acetylglucosamine in 3T3-L1 adipocytes
    • Whelan S.A., Dias W.B., Thiruneelakantapillai L., Lane M.D., Hart G.W. Regulation of insulin receptor substrate 1 (IRS-1)/AKT kinase-mediated insulin signaling by O-Linked beta-N-acetylglucosamine in 3T3-L1 adipocytes. J. Biol. Chem. 2010, 285:5204-5211.
    • (2010) J. Biol. Chem. , vol.285 , pp. 5204-5211
    • Whelan, S.A.1    Dias, W.B.2    Thiruneelakantapillai, L.3    Lane, M.D.4    Hart, G.W.5
  • 105
    • 33846117134 scopus 로고    scopus 로고
    • The signaling mechanism of ROS in tumor progression
    • Wu W.S. The signaling mechanism of ROS in tumor progression. Cancer Metastasis Rev. 2006, 25:695-705.
    • (2006) Cancer Metastasis Rev. , vol.25 , pp. 695-705
    • Wu, W.S.1
  • 106
    • 33749160125 scopus 로고    scopus 로고
    • Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability
    • Yang W.H., Kim J.E., Nam H.W., Ju J.W., Kim H.S., Kim Y.S., Cho J.W. Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability. Nat. Cell Biol. 2006, 8:1074-1083.
    • (2006) Nat. Cell Biol. , vol.8 , pp. 1074-1083
    • Yang, W.H.1    Kim, J.E.2    Nam, H.W.3    Ju, J.W.4    Kim, H.S.5    Kim, Y.S.6    Cho, J.W.7
  • 108
    • 3042613480 scopus 로고    scopus 로고
    • O-GlcNAc a sensor of cellular state: the role of nucleocytoplasmic glycosylation in modulating cellular function in response to nutrition and stress
    • Zachara N.E., Hart G.W. O-GlcNAc a sensor of cellular state: the role of nucleocytoplasmic glycosylation in modulating cellular function in response to nutrition and stress. Biochim. Biophys. Acta 2004, 1673:13-28.
    • (2004) Biochim. Biophys. Acta , vol.1673 , pp. 13-28
    • Zachara, N.E.1    Hart, G.W.2


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