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Volumn 366, Issue 1568, 2011, Pages 1204-1218

Understanding the role of growth factors in embryonic development: Insights from the lens

Author keywords

Akt PI3K; Cell signalling; Differentiation; Growth factors; Lens development; MAPK

Indexed keywords

EMBRYONIC DEVELOPMENT; EYE; GROWTH RATE; MOLECULAR ANALYSIS; MORPHOGENESIS;

EID: 79960623748     PISSN: 09628436     EISSN: 14712970     Source Type: Journal    
DOI: 10.1098/rstb.2010.0339     Document Type: Review
Times cited : (85)

References (139)
  • 1
    • 0017903759 scopus 로고
    • Cell division, cell elongation and distribution of alpha-, beta-and gamma-crystallins in the rat lens
    • McAvoy, J. W. 1978 Cell division, cell elongation and distribution of alpha-, beta-and gamma-crystallins in the rat lens. J. Embryol. Exp. Morphol. 44, 149-165.
    • (1978) J. Embryol. Exp. Morphol , vol.44 , pp. 149-165
    • McAvoy, J.W.1
  • 2
    • 0001752934 scopus 로고
    • Lens development: Fiber elongation and lens orientation
    • (doi:10.1126/science.142.3598.1489)
    • Coulombre, J. L. & Coulombre, A. J. 1963 Lens development: fiber elongation and lens orientation. Science 142, 1489-1490. (doi:10.1126/science.142.3598.1489)
    • (1963) Science , vol.142 , pp. 1489-1490
    • Coulombre, J.L.1    Coulombre, A.J.2
  • 3
    • 0017037796 scopus 로고
    • Growth of lens and ocular environment: Role of neural retina in the growth of mouse lens as revealed by an implantation experiment
    • (doi:10.1111/j.1440-169X.1976. 00273.x)
    • Yamamoto, Y. 1976 Growth of lens and ocular environment: role of neural retina in the growth of mouse lens as revealed by an implantation experiment. Dev. Growth Differ. 18, 273-278. (doi:10.1111/j.1440-169X.1976. 00273.x)
    • (1976) Dev. Growth Differ , vol.18 , pp. 273-278
    • Yamamoto, Y.1
  • 4
    • 14844323116 scopus 로고    scopus 로고
    • Growth factor regulation of lens development
    • (doi:10.1016/j.ydbio.2005.01.020)
    • Lovicu, F. J. & McAvoy, J. W. 2005 Growth factor regulation of lens development. Dev. Biol. 280, 1-14. (doi:10.1016/j.ydbio.2005.01.020)
    • (2005) Dev. Biol , vol.280 , pp. 1-14
    • Lovicu, F.J.1    McAvoy, J.W.2
  • 5
    • 77249138150 scopus 로고    scopus 로고
    • Development and use of the lens epithelial explant system to study lens differentiation and cataractogenesis
    • (doi:10.1016/j.preteyeres. 2009.12.001)
    • West-Mays, J. A., Pino, G. & Lovicu, F. J. 2009 Development and use of the lens epithelial explant system to study lens differentiation and cataractogenesis. Prog. Retin. Eye Res. 29, 135-143. (doi:10.1016/j.preteyeres. 2009.12.001)
    • (2009) Prog. Retin. Eye Res , vol.29 , pp. 135-143
    • West-Mays, J.A.1    Pino, G.2    Lovicu, F.J.3
  • 6
    • 0023412001 scopus 로고
    • Evidence that fibroblast growth factor promotes lens fibre differentiation
    • (doi:10.3109/ 02713688709034890)
    • Chamberlain, C. G. & McAvoy, J. W. 1987 Evidence that fibroblast growth factor promotes lens fibre differentiation. Curr. Eye Res. 6, 1165-1169. (doi:10.3109/ 02713688709034890)
    • (1987) Curr. Eye Res , vol.6 , pp. 1165-1169
    • Chamberlain, C.G.1    McAvoy, J.W.2
  • 7
    • 0024152068 scopus 로고
    • Induction of lens fibre differentiation by acidic and basic fibroblast growth factor (FGF)
    • (doi:10.3109/08977198909029122)
    • Chamberlain, C. G. & McAvoy, J. W. 1989 Induction of lens fibre differentiation by acidic and basic fibroblast growth factor (FGF). Growth Factors 1, 125-134. (doi:10.3109/08977198909029122)
    • (1989) Growth Factors , vol.1 , pp. 125-134
    • Chamberlain, C.G.1    McAvoy, J.W.2
  • 8
    • 0024458628 scopus 로고
    • Fibroblast growth factor (FGF) induces different responses in lens epithelial cells depending on its concentration
    • McAvoy, J. W. & Chamberlain, C. G. 1989 Fibroblast growth factor (FGF) induces different responses in lens epithelial cells depending on its concentration. Development 107, 221-228.
    • (1989) Development , vol.107 , pp. 221-228
    • McAvoy, J.W.1    Chamberlain, C.G.2
  • 9
    • 0024452724 scopus 로고
    • Structural analysis of lens epithelial explants induced to differentiate into fibres by fibroblast growth factor (FGF)
    • (doi:10.1016/0014-4835 (89)90056-0)
    • Lovicu, F. J. & McAvoy, J. W. 1989 Structural analysis of lens epithelial explants induced to differentiate into fibres by fibroblast growth factor (FGF). Exp. Eye Res. 49, 479-494. (doi:10.1016/0014-4835(89)90056-0)
    • (1989) Exp. Eye Res , vol.49 , pp. 479-494
    • Lovicu, F.J.1    McAvoy, J.W.2
  • 10
    • 0027180696 scopus 로고
    • Acidic and basic FGF in ocular media and lens: Implications for lens polarity and growth patterns
    • Schulz, M. W., Chamberlain, C. G., de Iongh, R. U. & McAvoy, J. W. 1993 Acidic and basic FGF in ocular media and lens: implications for lens polarity and growth patterns. Development 118, 117-126.
    • (1993) Development , vol.118 , pp. 117-126
    • Schulz, M.W.1    Chamberlain, C.G.2    de Iongh, R.U.3    McAvoy, J.W.4
  • 11
    • 0030895752 scopus 로고    scopus 로고
    • Fiber differentiation and polarity in the mammalian lens: A key role for FGF
    • (doi:10.1016/S1350-9462 (96)00034-1)
    • Chamberlain, C. G. & McAvoy, J. W. 1997 Fiber differentiation and polarity in the mammalian lens: a key role for FGF. Prog. Retin. Eye Res. 16, 443-478. (doi:10.1016/S1350-9462(96)00034-1)
    • (1997) Prog. Retin. Eye Res , vol.16 , pp. 443-478
    • Chamberlain, C.G.1    McAvoy, J.W.2
  • 12
    • 0029038613 scopus 로고
    • Differential effects of aqueous and vitreous on fiber differentiation and extracellular matrix accumulation in lens epithelial explants
    • Lovicu, F. J., Chamberlain, C. G. & McAvoy, J.W. 1995 Differential effects of aqueous and vitreous on fiber differentiation and extracellular matrix accumulation in lens epithelial explants. Invest. Ophthalmol. Vis. Sci. 36, 1459-1469.
    • (1995) Invest. Ophthalmol. Vis. Sci , vol.36 , pp. 1459-1469
    • Lovicu, F.J.1    Chamberlain, C.G.2    McAvoy, J.W.3
  • 13
    • 0031595782 scopus 로고    scopus 로고
    • Overlapping effects of different members of the FGF family on lens fiber differentiation in transgenic mice
    • Lovicu, F. J. & Overbeek, P. A. 1998 Overlapping effects of different members of the FGF family on lens fiber differentiation in transgenic mice. Development 125, 3365-3377.
    • (1998) Development , vol.125 , pp. 3365-3377
    • Lovicu, F.J.1    Overbeek, P.A.2
  • 15
    • 0030764274 scopus 로고    scopus 로고
    • Differential expression of fibroblast growth factor receptors during rat lens morphogenesis and growth
    • de Iongh, R. U., Lovicu, F. J., Chamberlain, C. G. & McAvoy, J. W. 1997 Differential expression of fibroblast growth factor receptors during rat lens morphogenesis and growth. Invest. Ophthalmol. Vis. Sci. 38, 1688-1699.
    • (1997) Invest. Ophthalmol. Vis. Sci , vol.38 , pp. 1688-1699
    • de Iongh, R.U.1    Lovicu, F.J.2    Chamberlain, C.G.3    McAvoy, J.W.4
  • 16
    • 0029741796 scopus 로고    scopus 로고
    • FGF receptor-1 (flg) expression is correlated with fibre differentiation during rat lens morphogenesis and growth
    • (doi:10.1002/(SICI)1097-0177 (199608)206:4<412:: AID-AJA7>3.0.CO;2-L)
    • de Iongh, R. U., Lovicu, F. J., Hanneken, A., Baird, A. & McAvoy, J. W. 1996 FGF receptor-1 (flg) expression is correlated with fibre differentiation during rat lens morphogenesis and growth. Dev. Dyn. 206, 412-426. (doi:10.1002/(SICI)1097-0177(199608)206:4<412:: AID-AJA7>3.0.CO;2-L)
    • (1996) Dev. Dyn , vol.206 , pp. 412-426
    • de Iongh, R.U.1    Lovicu, F.J.2    Hanneken, A.3    Baird, A.4    McAvoy, J.W.5
  • 17
    • 33846401811 scopus 로고    scopus 로고
    • An essential role for FGF receptor signaling in lens development
    • (doi:10.1016/j.semcdb.2006.10.002)
    • Robinson, M. L. 2006 An essential role for FGF receptor signaling in lens development. Semin. Cell Dev. Biol. 17, 726-740. (doi:10.1016/j.semcdb.2006.10.002)
    • (2006) Semin. Cell Dev. Biol , vol.17 , pp. 726-740
    • Robinson, M.L.1
  • 18
    • 44349136203 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation
    • (doi:10.1016/j.ydbio.2008. 03.028)
    • Zhao, H. et al. 2008 Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation. Dev. Biol. 318, 276-288. (doi:10.1016/j.ydbio.2008. 03.028)
    • (2008) Dev. Biol , vol.318 , pp. 276-288
    • Zhao, H.1
  • 19
    • 0031900740 scopus 로고    scopus 로고
    • Signal transduction through MAP kinase cascades
    • (doi:10.1016/S0065-230X (08)60765-4)
    • Lewis, T. S., Shapiro, P. S. & Ahn, N. G. 1998 Signal transduction through MAP kinase cascades. Adv. Cancer Res. 74, 49-139. (doi:10.1016/S0065-230X(08)60765-4)
    • (1998) Adv. Cancer Res , vol.74 , pp. 49-139
    • Lewis, T.S.1    Shapiro, P.S.2    Ahn, N.G.3
  • 20
    • 0032935664 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases: Specific messages from ubiquitous messengers
    • Schaeffer, H. J. & Weber, M. J. 1999 Mitogen-activated protein kinases: specific messages from ubiquitous messengers. Mol. Cell Biol. 19, 2435-2444.
    • (1999) Mol. Cell Biol , vol.19 , pp. 2435-2444
    • Schaeffer, H.J.1    Weber, M.J.2
  • 21
    • 0035691974 scopus 로고    scopus 로고
    • FGF-induced lens cell proliferation and differentiation is dependent on MAPK (ERK1/2) signalling
    • Lovicu, F. J. & McAvoy, J. W. 2001 FGF-induced lens cell proliferation and differentiation is dependent on MAPK (ERK1/2) signalling. Development 128, 5075-5084.
    • (2001) Development , vol.128 , pp. 5075-5084
    • Lovicu, F.J.1    McAvoy, J.W.2
  • 22
    • 0035873624 scopus 로고    scopus 로고
    • FGF signaling in chick lens development
    • (doi:10. 1006/dbio.2001.0194)
    • Le, A. C. & Musil, L. S. 2001 FGF signaling in chick lens development. Dev. Biol. 233, 394-411. (doi:10. 1006/dbio.2001.0194)
    • (2001) Dev. Biol , vol.233 , pp. 394-411
    • Le, A.C.1    Musil, L.S.2
  • 23
    • 61849162290 scopus 로고    scopus 로고
    • MAPK/ERK1/2 and PI3-kinase signalling pathways are required for vitreous-induced lens fibre cell differentiation
    • (doi:10. 1016/j.exer.2008.08.023)
    • Wang, Q., Stump, R., McAvoy, J. W. & Lovicu, F. J. 2009 MAPK/ERK1/2 and PI3-kinase signalling pathways are required for vitreous-induced lens fibre cell differentiation. Exp. Eye Res. 88, 293-306. (doi:10. 1016/j.exer.2008.08.023)
    • (2009) Exp. Eye Res , vol.88 , pp. 293-306
    • Wang, Q.1    Stump, R.2    McAvoy, J.W.3    Lovicu, F.J.4
  • 24
    • 77950491986 scopus 로고    scopus 로고
    • Sprouty2-modulated Kras signaling rescues Shp2 deficiency during lens and lacrimal gland development
    • (doi:10.1242/dev. 042820)
    • Pan, Y., Carbe, C., Powers, A., Feng, G. S. & Zhang, X. 2010 Sprouty2-modulated Kras signaling rescues Shp2 deficiency during lens and lacrimal gland development. Development 137, 1085-1093. (doi:10.1242/dev. 042820)
    • (2010) Development , vol.137 , pp. 1085-1093
    • Pan, Y.1    Carbe, C.2    Powers, A.3    Feng, G.S.4    Zhang, X.5
  • 25
    • 34548136241 scopus 로고    scopus 로고
    • Duration of ERK1/2 phosphorylation induced by FGF or ocular media determines lens cell fate
    • (doi:10.1111/j.1432-0436.2007.00167.x)
    • Iyengar, L., Wang, Q., Rasko, J. E., McAvoy, J. W. & Lovicu, F. J. 2007 Duration of ERK1/2 phosphorylation induced by FGF or ocular media determines lens cell fate. Differentiation 75, 662-668. (doi:10.1111/j.1432-0436.2007.00167.x)
    • (2007) Differentiation , vol.75 , pp. 662-668
    • Iyengar, L.1    Wang, Q.2    Rasko, J.E.3    McAvoy, J.W.4    Lovicu, F.J.5
  • 26
    • 33745128008 scopus 로고    scopus 로고
    • Aqueous humour-and growth factor-induced lens cell proliferation is dependent on MAPK/ERK1/2 and Akt/PI3-K signalling
    • (doi:10.1016/j. exer.2006.03.008)
    • Iyengar, L., Patkunanathan, B., Lynch, O. T., McAvoy, J. W., Rasko, J. E. & Lovicu, F. J. 2006 Aqueous humour-and growth factor-induced lens cell proliferation is dependent on MAPK/ERK1/2 and Akt/PI3-K signalling. Exp. Eye Res. 83, 667-678. (doi:10.1016/j. exer.2006.03.008)
    • (2006) Exp. Eye Res , vol.83 , pp. 667-678
    • Iyengar, L.1    Patkunanathan, B.2    Lynch, O.T.3    McAvoy, J.W.4    Rasko, J.E.5    Lovicu, F.J.6
  • 27
    • 77955896445 scopus 로고    scopus 로고
    • Growth factor signaling in vitreous humour-induced lens fiber differentiation
    • (doi:10.1167/iovs.09-4797)
    • Wang, Q., McAvoy, J. W. & Lovicu, F. J. 2010 Growth factor signaling in vitreous humour-induced lens fiber differentiation. Invest. Ophthalmol. Vis. Sci. 51, 3599-3610. (doi:10.1167/iovs.09-4797)
    • (2010) Invest. Ophthalmol. Vis. Sci , vol.51 , pp. 3599-3610
    • Wang, Q.1    McAvoy, J.W.2    Lovicu, F.J.3
  • 28
    • 34047264135 scopus 로고    scopus 로고
    • In vitro generation of functional lens-like structures with relevance to age-related nuclear cataract
    • (doi:10.1167/iovs.06-0949)
    • O'Connor, M. D. & McAvoy, J. W. 2007 in vitro generation of functional lens-like structures with relevance to age-related nuclear cataract. Invest. Ophthalmol. Vis. Sci. 48, 1245-1252. (doi:10.1167/iovs.06-0949)
    • (2007) Invest. Ophthalmol. Vis. Sci , vol.48 , pp. 1245-1252
    • O'Connor, M.D.1    McAvoy, J.W.2
  • 29
    • 0032191312 scopus 로고    scopus 로고
    • Induction and maintenance of differentiation of rat lens epithelium by FGF-2, insulin and IGF-1
    • (doi:10.1006/ exer.1998.0534)
    • Klok, E., Lubsen, N. H., Chamberlain, C. G. & McAvoy, J. W. 1998 Induction and maintenance of differentiation of rat lens epithelium by FGF-2, insulin and IGF-1. Exp. Eye Res. 67, 425-431. (doi:10.1006/ exer.1998.0534)
    • (1998) Exp. Eye Res , vol.67 , pp. 425-431
    • Klok, E.1    Lubsen, N.H.2    Chamberlain, C.G.3    McAvoy, J.W.4
  • 30
    • 0030450532 scopus 로고    scopus 로고
    • IGF enhancement of FGF-induced fibre differentiation and DNA synthesis in lens explants
    • (doi:10.1006/exer.1996.0156)
    • Liu, J., Chamberlain, C. G. & McAvoy, J. W. 1996 IGF enhancement of FGF-induced fibre differentiation and DNA synthesis in lens explants. Exp. Eye Res. 63, 621-629. (doi:10.1006/exer.1996.0156)
    • (1996) Exp. Eye Res , vol.63 , pp. 621-629
    • Liu, J.1    Chamberlain, C.G.2    McAvoy, J.W.3
  • 31
    • 0027377973 scopus 로고
    • IGF-1 enhancement of FGF-induced lens fiber differentiation in rats of different ages
    • Richardson, N. A., Chamberlain, C. G. & McAvoy, J. W. 1993 IGF-1 enhancement of FGF-induced lens fiber differentiation in rats of different ages. Invest. Ophthalmol. Vis. Sci. 34, 3303-3312.
    • (1993) Invest. Ophthalmol. Vis. Sci , vol.34 , pp. 3303-3312
    • Richardson, N.A.1    Chamberlain, C.G.2    McAvoy, J.W.3
  • 32
    • 0141632494 scopus 로고
    • Lentropin, a protein that controls lens fiber formation, is related functionally and immunologically to the insulin-like growth factors
    • (doi:10.1073/pnas.84.8.2327)
    • Beebe, D. C., Silver, M. H., Belcher, K. S., van Wyk, J. J., Svoboda, M. E. & Zelenka, P. S. 1987 Lentropin, a protein that controls lens fiber formation, is related functionally and immunologically to the insulin-like growth factors. Proc. Natl Acad. Sci. USA 84, 2327-2330. (doi:10.1073/pnas.84.8.2327)
    • (1987) Proc. Natl Acad. Sci. USA , vol.84 , pp. 2327-2330
    • Beebe, D.C.1    Silver, M.H.2    Belcher, K.S.3    van Wyk, J.J.4    Svoboda, M.E.5    Zelenka, P.S.6
  • 33
    • 4444340720 scopus 로고    scopus 로고
    • Expression and activation of the epidermal growth factor receptor in differentiating cells of the developing and post-hatching chicken lens
    • (doi:10.1016/ j.exer.2004.05.012)
    • Ireland, M. E. & Mrock, L. K. 2004 Expression and activation of the epidermal growth factor receptor in differentiating cells of the developing and post-hatching chicken lens. Exp. Eye Res. 79, 305-312. (doi:10.1016/ j.exer.2004.05.012)
    • (2004) Exp. Eye Res , vol.79 , pp. 305-312
    • Ireland, M.E.1    Mrock, L.K.2
  • 34
    • 0034746742 scopus 로고    scopus 로고
    • A role for endogenous TGFalpha and associated signaling pathways in the differentiation of lens fiber cells
    • (doi:10.1002/1097-4652 (200002)186:2, 288::AID-JCP1031.3.0.CO;2-H)
    • Chen, F., Mrock, L. K. & Ireland, M. E. 2001 A role for endogenous TGFalpha and associated signaling pathways in the differentiation of lens fiber cells. J. Cell Physiol. 186, 288-297. (doi:10.1002/1097-4652(200002)186:2, 288::AID-JCP1031.3.0.CO;2-H)
    • (2001) J. Cell Physiol , vol.186 , pp. 288-297
    • Chen, F.1    Mrock, L.K.2    Ireland, M.E.3
  • 35
    • 0036672240 scopus 로고    scopus 로고
    • Bone morphogenetic protein signaling and the initiation of lens fiber cell differentiation
    • Belecky-Adams, T. L., Adler, R. & Beebe, D. C. 2002 Bone morphogenetic protein signaling and the initiation of lens fiber cell differentiation. Development 129, 3795-3802.
    • (2002) Development , vol.129 , pp. 3795-3802
    • Belecky-Adams, T.L.1    Adler, R.2    Beebe, D.C.3
  • 36
    • 0036677580 scopus 로고    scopus 로고
    • Bmp signaling is required for development of primary lens fiber cells
    • Faber, S. C., Robinson, M. L., Makarenkova, H. P. & Lang, R. A. 2002 Bmp signaling is required for development of primary lens fiber cells. Development 129, 3727-3737.
    • (2002) Development , vol.129 , pp. 3727-3737
    • Faber, S.C.1    Robinson, M.L.2    Makarenkova, H.P.3    Lang, R.A.4
  • 38
    • 48749088193 scopus 로고    scopus 로고
    • Crosstalk between fibroblast growth factor and bone morphogenetic proteins regulates gap junction-mediated intercellular communication in lens cells
    • (doi:10.1091/mbc.E08-02-0124)
    • Boswell, B. A., Lein, P. J. & Musil, L. S. 2008 Crosstalk between fibroblast growth factor and bone morphogenetic proteins regulates gap junction-mediated intercellular communication in lens cells. Mol. Biol. Cell. 19, 2631-2641. (doi:10.1091/mbc.E08-02-0124)
    • (2008) Mol. Biol. Cell , vol.19 , pp. 2631-2641
    • Boswell, B.A.1    Lein, P.J.2    Musil, L.S.3
  • 39
    • 56449131346 scopus 로고    scopus 로고
    • Essential role of BMPs in FGF-induced secondary lens fiber differentiation
    • (doi:10.1016/j.ydbio.2008.09.003)
    • Boswell, B. A., Overbeek, P. A. & Musil, L. S. 2008 Essential role of BMPs in FGF-induced secondary lens fiber differentiation. Dev. Biol. 324, 202-212. (doi:10.1016/j.ydbio.2008.09.003)
    • (2008) Dev. Biol , vol.324 , pp. 202-212
    • Boswell, B.A.1    Overbeek, P.A.2    Musil, L.S.3
  • 40
    • 2342430341 scopus 로고    scopus 로고
    • Wnt signaling enhances FGF2-triggered lens fiber cell differentiation
    • (doi:10.1242/dev.01060)
    • Lyu, J. & Joo, C. K. 2004 Wnt signaling enhances FGF2-triggered lens fiber cell differentiation. Development 131, 1813-1824. (doi:10.1242/dev.01060)
    • (2004) Development , vol.131 , pp. 1813-1824
    • Lyu, J.1    Joo, C.K.2
  • 41
    • 11144322833 scopus 로고    scopus 로고
    • Expression of Frizzleds and secreted frizzledrelated proteins (sFRPs) during mammalian lens development
    • (doi:10. 1387/ijdb.041882yc)
    • Chen, Y., Stump, R. J., Lovicu, F. J. & McAvoy, J. W. 2004 Expression of Frizzleds and secreted frizzledrelated proteins (sFRPs) during mammalian lens development. Int. J. Dev. Biol. 48, 867-877. (doi:10. 1387/ijdb.041882yc)
    • (2004) Int. J. Dev. Biol , vol.48 , pp. 867-877
    • Chen, Y.1    Stump, R.J.2    Lovicu, F.J.3    McAvoy, J.W.4
  • 42
    • 55749100664 scopus 로고    scopus 로고
    • Wnt signaling is required for organization of the lens fiber cell cytoskeleton and development of lens three-dimensional architecture
    • (doi:10.1016/j.ydbio.2008. 09.002)
    • Chen, Y., Stump, R. J., Lovicu, F. J., Shimono, A. & McAvoy, J. W. 2008 Wnt signaling is required for organization of the lens fiber cell cytoskeleton and development of lens three-dimensional architecture. Dev. Biol. 324, 161-176. (doi:10.1016/j.ydbio.2008. 09.002)
    • (2008) Dev. Biol , vol.324 , pp. 161-176
    • Chen, Y.1    Stump, R.J.2    Lovicu, F.J.3    Shimono, A.4    McAvoy, J.W.5
  • 43
    • 51449087345 scopus 로고    scopus 로고
    • Differential requirement for beta-catenin in epithelial and fiber cells during lens development
    • (doi:10.1016/j. ydbio.2008.07.002)
    • Cain, S., Martinez, G., Kokkinos, M. I., Turner, K., Richardson, R. J., Abud, H. E., Huelsken, J., Robinson, M. & de Iongh, R. 2008 Differential requirement for beta-catenin in epithelial and fiber cells during lens development. Dev. Biol. 321, 420-433. (doi:10.1016/j. ydbio.2008.07.002)
    • (2008) Dev. Biol , vol.321 , pp. 420-433
    • Cain, S.1    Martinez, G.2    Kokkinos, M.I.3    Turner, K.4    Richardson, R.J.5    Abud, H.E.6    Huelsken, J.7    Robinson, M.8    de Iongh, R.9
  • 44
    • 70349575235 scopus 로고    scopus 로고
    • Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation
    • (doi:10.1167/iovs.09-3567)
    • Martinez, G., Wijesinghe, M., Turner, K., Abud, H. E., Taketo, M. M., Noda, T., Robinson, M. L. & de Iongh, R. U. 2009 Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation. Invest. Ophthalmol. Vis. Sci. 50, 4794-4806. (doi:10.1167/iovs.09-3567)
    • (2009) Invest. Ophthalmol. Vis. Sci , vol.50 , pp. 4794-4806
    • Martinez, G.1    Wijesinghe, M.2    Turner, K.3    Abud, H.E.4    Taketo, M.M.5    Noda, T.6    Robinson, M.L.7    de Iongh, R.U.8
  • 45
    • 0035866056 scopus 로고    scopus 로고
    • Bmp4 mediates apoptotic cell death in the developing chick eye
    • Trousse, F., Esteve, P. & Bovolenta, P. 2001 Bmp4 mediates apoptotic cell death in the developing chick eye. J. Neurosci. 21, 1292-1301.
    • (2001) J. Neurosci , vol.21 , pp. 1292-1301
    • Trousse, F.1    Esteve, P.2    Bovolenta, P.3
  • 46
    • 0036340690 scopus 로고    scopus 로고
    • The role of bone morphogenetic proteins in the differentiation of the ventral optic cup
    • Adler, R. & Belecky-Adams, T. L. 2002 The role of bone morphogenetic proteins in the differentiation of the ventral optic cup. Development 129, 3161-3171.
    • (2002) Development , vol.129 , pp. 3161-3171
    • Adler, R.1    Belecky-Adams, T.L.2
  • 47
    • 7044262316 scopus 로고    scopus 로고
    • BMP and activin receptor expression in lens development
    • de Iongh, R. U., Chen, Y., Kokkinos, M. I. & McAvoy, J. W. 2004 BMP and activin receptor expression in lens development. Mol. Vis. 10, 566-576.
    • (2004) Mol. Vis , vol.10 , pp. 566-576
    • de Iongh, R.U.1    Chen, Y.2    Kokkinos, M.I.3    McAvoy, J.W.4
  • 48
    • 0036189627 scopus 로고    scopus 로고
    • Retinal ablation and altered lens differentiation induced by ocular overexpression of BMP7
    • (doi:10.1016/S0042-6989 (01)00242-5)
    • Hung, F. C., Zhao, S., Chen, Q. & Overbeek, P. A. 2002 Retinal ablation and altered lens differentiation induced by ocular overexpression of BMP7. Vision Res. 42, 427-438. (doi:10.1016/S0042-6989(01)00242-5)
    • (2002) Vision Res , vol.42 , pp. 427-438
    • Hung, F.C.1    Zhao, S.2    Chen, Q.3    Overbeek, P.A.4
  • 49
    • 0032101553 scopus 로고    scopus 로고
    • Disregulation of ocular morphogenesis by lens-specific expression of FGF-3/int-2 in transgenic mice
    • (doi:10.1016/ S0012-1606 (98)80026-2)
    • Robinson, M. L., Ohtaka-Maruyama, C., Chan, C. C., Jamieson, S., Dickson, C., Overbeek, P. A. & Chepelinsky, A. 1998 Disregulation of ocular morphogenesis by lens-specific expression of FGF-3/int-2 in transgenic mice. Dev. Biol. 198, 13-31. (doi:10.1016/ S0012-1606(98)80026-2)
    • (1998) Dev. Biol , vol.198 , pp. 13-31
    • Robinson, M.L.1    Ohtaka-Maruyama, C.2    Chan, C.C.3    Jamieson, S.4    Dickson, C.5    Overbeek, P.A.6    Chepelinsky, A.7
  • 52
    • 0026799402 scopus 로고
    • Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease
    • (doi:10.1038/359693a0)
    • Shull, M. M. et al. 1992 Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 359, 693-699. (doi:10.1038/359693a0)
    • (1992) Nature , vol.359 , pp. 693-699
    • Shull, M.M.1
  • 53
    • 0028176755 scopus 로고
    • Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction
    • (doi:10. 1101/gad.8.4.414)
    • Vassalli, A., Matzuk, M. M., Gardner, H. A., Lee, K. F. & Jaenisch, R. 1994 Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction. Genes Dev. 8, 414-427. (doi:10. 1101/gad.8.4.414)
    • (1994) Genes Dev , vol.8 , pp. 414-427
    • Vassalli, A.1    Matzuk, M.M.2    Gardner, H.A.3    Lee, K.F.4    Jaenisch, R.5
  • 55
    • 19944386897 scopus 로고    scopus 로고
    • Contributions by members of the TGFbeta superfamily to lens development
    • (doi:10.1387/ijdb.041869db)
    • Beebe, D. et al. 2004 Contributions by members of the TGFbeta superfamily to lens development. Int. J. Dev. Biol. 48, 845-856. (doi:10.1387/ijdb.041869db)
    • (2004) Int. J. Dev. Biol , vol.48 , pp. 845-856
    • Beebe, D.1
  • 56
    • 33947600344 scopus 로고    scopus 로고
    • Focal adhesion kinase (FAK) expression and activation during lens development
    • Kokkinos, M. I., Brown, H. J. & de Iongh, R. U. 2007 Focal adhesion kinase (FAK) expression and activation during lens development. Mol. Vis. 13, 418-430.
    • (2007) Mol. Vis , vol.13 , pp. 418-430
    • Kokkinos, M.I.1    Brown, H.J.2    de Iongh, R.U.3
  • 57
    • 33646035242 scopus 로고    scopus 로고
    • Activin receptor-like kinases: Structure, function and clinical implications
    • Graham, H. & Peng, C. 2006 Activin receptor-like kinases: structure, function and clinical implications. Endocr. Metab. Immune Disord. Drug Targets 6, 45-58.
    • (2006) Endocr. Metab. Immune Disord. Drug Targets , vol.6 , pp. 45-58
    • Graham, H.1    Peng, C.2
  • 58
    • 8444251784 scopus 로고    scopus 로고
    • The Wnt signaling pathway in development and disease
    • (doi:10.1146/annurev.cellbio.20. 010403.113126)
    • Logan, C. Y. & Nusse, R. 2004 The Wnt signaling pathway in development and disease. Annu. Rev. Cell Dev. Biol. 20, 781-810. (doi:10.1146/annurev.cellbio.20. 010403.113126)
    • (2004) Annu. Rev. Cell Dev. Biol , vol.20 , pp. 781-810
    • Logan, C.Y.1    Nusse, R.2
  • 60
    • 67650230896 scopus 로고    scopus 로고
    • Wnt/betacatenin signaling: Components, mechanisms, and diseases
    • (doi:10.1016/j.devcel.2009. 06.016)
    • MacDonald, B. T., Tamai, K. & He, X. 2009 Wnt/betacatenin signaling: components, mechanisms, and diseases. Dev. Cell 17, 9-26. (doi:10.1016/j.devcel.2009. 06.016)
    • (2009) Dev. Cell , vol.17 , pp. 9-26
    • McDonald, B.T.1    Tamai, K.2    He, X.3
  • 61
    • 70349932747 scopus 로고    scopus 로고
    • Towards an integrated view of Wnt signaling in development
    • (doi:10.1242/dev.033910)
    • van Amerongen, R. & Nusse, R. 2009 Towards an integrated view of Wnt signaling in development. Development 136, 3205-3214. (doi:10.1242/dev.033910)
    • (2009) Development , vol.136 , pp. 3205-3214
    • van Amerongen, R.1    Nusse, R.2
  • 62
    • 33745875300 scopus 로고    scopus 로고
    • Planar cell polarity and vertebrate organogenesis
    • (doi:10.1016/j. semcdb.2006.05.003)
    • Karner, C., Wharton Jr, K. A. & Carroll, T. J. 2006 Planar cell polarity and vertebrate organogenesis. Semin. Cell Dev. Biol. 17, 194-203. (doi:10.1016/j. semcdb.2006.05.003)
    • (2006) Semin. Cell Dev. Biol , vol.17 , pp. 194-203
    • Karner, C.1    Wharton Jr., K.A.2    Carroll, T.J.3
  • 63
    • 33847337998 scopus 로고    scopus 로고
    • Planar cell polarity signaling in vertebrates
    • (doi:10.1002/ bies.20526)
    • Jones, C. & Chen, P. 2007 Planar cell polarity signaling in vertebrates. Bioessays 29, 120-132. (doi:10.1002/ bies.20526)
    • (2007) Bioessays , vol.29 , pp. 120-132
    • Jones, C.1    Chen, P.2
  • 64
    • 8444223093 scopus 로고    scopus 로고
    • Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP
    • (doi:10.1242/dev.01318)
    • Cong, F., Schweizer, L. & Varmus, H. 2004 Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP. Development 131, 5103-5115. (doi:10.1242/dev.01318)
    • (2004) Development , vol.131 , pp. 5103-5115
    • Cong, F.1    Schweizer, L.2    Varmus, H.3
  • 65
    • 0037664300 scopus 로고    scopus 로고
    • Characterization of Wnt signaling components and activation of the Wnt canonical pathway in the murine retina
    • (doi:10.1002/ dvdy.10315)
    • Liu, H., Mohamed, O., Dufort, D. & Wallace, V. A. 2003 Characterization of Wnt signaling components and activation of the Wnt canonical pathway in the murine retina. Dev. Dyn. 227, 323-334. (doi:10.1002/ dvdy.10315)
    • (2003) Dev. Dyn , vol.227 , pp. 323-334
    • Liu, H.1    Mohamed, O.2    Dufort, D.3    Wallace, V.A.4
  • 66
    • 27744535862 scopus 로고    scopus 로고
    • The developmental biology of Dishevelled: An enigmatic protein governing cell fate and cell polarity
    • (doi:10.1242/dev.02068)
    • Wallingford, J. B. & Habas, R. 2005 The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity. Development 132, 4421-4436. (doi:10.1242/dev.02068)
    • (2005) Development , vol.132 , pp. 4421-4436
    • Wallingford, J.B.1    Habas, R.2
  • 67
    • 34247123655 scopus 로고    scopus 로고
    • Mapping canonical Wnt signaling in the developing and adult retina
    • (doi:10.1167/iovs.06-0403)
    • Liu, H., Thurig, S., Mohamed, O., Dufort, D. & Wallace, V. A. 2006 Mapping canonical Wnt signaling in the developing and adult retina. Invest. Ophthalmol. Vis. Sci. 47, 5088-5097. (doi:10.1167/iovs.06-0403)
    • (2006) Invest. Ophthalmol. Vis. Sci , vol.47 , pp. 5088-5097
    • Liu, H.1    Thurig, S.2    Mohamed, O.3    Dufort, D.4    Wallace, V.A.5
  • 68
    • 34447643594 scopus 로고    scopus 로고
    • Ciliary margin transdifferentiation from neural retina is controlled by canonical Wnt signaling
    • (doi:10.1016/j.ydbio. 2007.04.052)
    • Liu, H. et al. 2007 Ciliary margin transdifferentiation from neural retina is controlled by canonical Wnt signaling. Dev. Biol. 308, 54-67. (doi:10.1016/j.ydbio. 2007.04.052)
    • (2007) Dev. Biol , vol.308 , pp. 54-67
    • Liu, H.1
  • 69
    • 45849142919 scopus 로고    scopus 로고
    • Wnt signaling in eye organogenesis
    • (doi:10.4161/org.4.2.5850)
    • Fuhrmann, S. 2008 Wnt signaling in eye organogenesis. Organogenesis 4, 60-67. (doi:10.4161/org.4.2.5850)
    • (2008) Organogenesis , vol.4 , pp. 60-67
    • Fuhrmann, S.1
  • 70
    • 58249085325 scopus 로고    scopus 로고
    • Characterization of a transient TCF/LEF-responsive progenitor population in the embryonic mouse retina
    • (doi:10. 1167/iovs.08-2270)
    • Fuhrmann, S., Riesenberg, A. N., Mathiesen, A. M., Brown, E. C., Vetter, M. L. & Brown, N. L. 2009 Characterization of a transient TCF/LEF-responsive progenitor population in the embryonic mouse retina. Invest. Ophthalmol. Vis. Sci. 50, 432-440. (doi:10. 1167/iovs.08-2270)
    • (2009) Invest. Ophthalmol. Vis. Sci , vol.50 , pp. 432-440
    • Fuhrmann, S.1    Riesenberg, A.N.2    Mathiesen, A.M.3    Brown, E.C.4    Vetter, M.L.5    Brown, N.L.6
  • 71
    • 69049085662 scopus 로고    scopus 로고
    • Betacatenin controls differentiation of the retinal pigment epithelium in the mouse optic cup by regulating Mitf and Otx2 expression
    • (doi:10.1242/dev.032136)
    • Westenskow, P., Piccolo, S. & Fuhrmann, S. 2009 Betacatenin controls differentiation of the retinal pigment epithelium in the mouse optic cup by regulating Mitf and Otx2 expression. Development 136, 2505-2510. (doi:10.1242/dev.032136)
    • (2009) Development , vol.136 , pp. 2505-2510
    • Westenskow, P.1    Piccolo, S.2    Fuhrmann, S.3
  • 72
    • 1642418216 scopus 로고    scopus 로고
    • Spatial and temporal expression of Wnt and Dickkopf genes during murine lens development
    • (doi:10.1016/j.modgep. 2003.11.002)
    • Ang, S. J., Stump, R. J., Lovicu, F. J. & McAvoy, J. W. 2004 Spatial and temporal expression of Wnt and Dickkopf genes during murine lens development. Gene Exp. Patterns 4, 289-295. (doi:10.1016/j.modgep. 2003.11.002)
    • (2004) Gene Exp. Patterns , vol.4 , pp. 289-295
    • Ang, S.J.1    Stump, R.J.2    Lovicu, F.J.3    McAvoy, J.W.4
  • 73
    • 33749080749 scopus 로고    scopus 로고
    • Lithium stabilizes the polarized lens epithelial phenotype and inhibits proliferation, migration, and epithelial mesenchymal transition
    • (doi:10.1002/path.2049)
    • Stump, R. J., Lovicu, F. J., Ang, S. L., Pandey, S. K. & McAvoy, J. W. 2006 Lithium stabilizes the polarized lens epithelial phenotype and inhibits proliferation, migration, and epithelial mesenchymal transition. J. Pathol. 210, 249-257. (doi:10.1002/path.2049)
    • (2006) J. Pathol , vol.210 , pp. 249-257
    • Stump, R.J.1    Lovicu, F.J.2    Ang, S.L.3    Pandey, S.K.4    McAvoy, J.W.5
  • 74
    • 10644282055 scopus 로고    scopus 로고
    • Embryonic expression of three mouse genes with homology to the Drosophila melanogaster prickle gene
    • (doi:10.1016/S0925-4773 (03)00095-9)
    • Bekman, E. & Henrique, D. 2002 Embryonic expression of three mouse genes with homology to the Drosophila melanogaster prickle gene. Mech. Dev. 119(Suppl. 1), S77-S81. (doi:10.1016/S0925-4773 (03)00095-9)
    • (2002) Mech. Dev , vol.119 , Issue.SUPPL. 1
    • Bekman, E.1    Henrique, D.2
  • 75
    • 33644950699 scopus 로고    scopus 로고
    • Expression of planar cell polarity genes during development of the mouse CNS
    • (doi:10.1111/j. 1460-9568.2006.04596.x)
    • Tissir, F. & Goffinet, A. M. 2006 Expression of planar cell polarity genes during development of the mouse CNS. Eur. J. Neurosci. 23, 597-607. (doi:10.1111/j. 1460-9568.2006.04596.x)
    • (2006) Eur. J. Neurosci , vol.23 , pp. 597-607
    • Tissir, F.1    Goffinet, A.M.2
  • 76
    • 33846394751 scopus 로고    scopus 로고
    • A role for Wnt/planar cell polarity signaling during lens fiber cell differentiation?
    • (doi:10.1016/j.semcdb.2006.11.005)
    • Chen, Y., Stump, R. J., Lovicu, F. J. & McAvoy, J. W. 2006 A role for Wnt/planar cell polarity signaling during lens fiber cell differentiation? Semin. Cell Dev. Biol. 17, 712-725. (doi:10.1016/j.semcdb.2006.11.005)
    • (2006) Semin. Cell Dev. Biol , vol.17 , pp. 712-725
    • Chen, Y.1    Stump, R.J.2    Lovicu, F.J.3    McAvoy, J.W.4
  • 77
    • 0036172408 scopus 로고    scopus 로고
    • Rho GTPase inactivation impairs lens growth and integrity
    • Rao, V., Wawrousek, E., Tamm, E. R. & Zigler Jr, S. 2002 Rho GTPase inactivation impairs lens growth and integrity. Lab. Invest. 82, 231-239.
    • (2002) Lab. Invest , vol.82 , pp. 231-239
    • Rao, V.1    Wawrousek, E.2    Tamm, E.R.3    Zigler Jr., S.4
  • 78
    • 39249084792 scopus 로고    scopus 로고
    • Rho GDP dissociation inhibitor-mediated disruption of Rho GTPase activity impairs lens fiber cell migration, elongation and survival
    • (doi:10.1016/j.ydbio.2007.12.039)
    • Maddala, R., Reneker, L.W., Pendurthi, B. & Rao, P. V. 2008 Rho GDP dissociation inhibitor-mediated disruption of Rho GTPase activity impairs lens fiber cell migration, elongation and survival. Dev. Biol. 315, 217-231. (doi:10.1016/j.ydbio.2007.12.039)
    • (2008) Dev. Biol , vol.315 , pp. 217-231
    • Maddala, R.1    Reneker, L.W.2    Pendurthi, B.3    Rao, P.V.4
  • 79
    • 2642544131 scopus 로고    scopus 로고
    • Impaired cytoskeletal organization and membrane integrity in lens fibers of a Rho GTPase functional knockout transgenic mouse
    • (doi:10.1038/labinvest. 3700105)
    • Maddala, R., Deng, P. F., Costello, J. M., Wawrousek, E. F., Zigler, J. S. & Rao, V. P. 2004 Impaired cytoskeletal organization and membrane integrity in lens fibers of a Rho GTPase functional knockout transgenic mouse. Lab. Invest. 84, 679-692. (doi:10.1038/labinvest. 3700105)
    • (2004) Lab. Invest , vol.84 , pp. 679-692
    • Maddala, R.1    Deng, P.F.2    Costello, J.M.3    Wawrousek, E.F.4    Zigler, J.S.5    Rao, V.P.6
  • 80
    • 0034799573 scopus 로고    scopus 로고
    • Lovastatin-induced cytoskeletal reorganization in lens epithelial cells: Role of Rho GTPases
    • Maddala, R. L., Reddy, V. N. & Rao, P. V. 2001 Lovastatin-induced cytoskeletal reorganization in lens epithelial cells: role of Rho GTPases. Invest. Ophthalmol. Vis. Sci. 42, 2610-2615.
    • (2001) Invest. Ophthalmol. Vis. Sci , vol.42 , pp. 2610-2615
    • Maddala, R.L.1    Reddy, V.N.2    Rao, P.V.3
  • 81
    • 34250781731 scopus 로고    scopus 로고
    • Planar cell polarity: One or two pathways?
    • (doi:10.1038/nrg2125)
    • Lawrence, P. A., Struhl, G. & Casal, J. 2007 Planar cell polarity: one or two pathways? Nat. Rev. Genet. 8, 555-563. (doi:10.1038/nrg2125)
    • (2007) Nat. Rev. Genet , vol.8 , pp. 555-563
    • Lawrence, P.A.1    Struhl, G.2    Casal, J.3
  • 82
    • 33947327064 scopus 로고    scopus 로고
    • Tissue/planar cell polarity in vertebrates: New insights and new questions
    • (doi:10.1242/dev.02772)
    • Wang, Y. & Nathans, J. 2007 Tissue/planar cell polarity in vertebrates: new insights and new questions. Development 134, 647-658. (doi:10.1242/dev.02772)
    • (2007) Development , vol.134 , pp. 647-658
    • Wang, Y.1    Nathans, J.2
  • 83
    • 37549032486 scopus 로고    scopus 로고
    • Basal bodies, kinocilia and planar cell polarity
    • (doi:10.1038/ng0108-10)
    • Axelrod, J. D. 2008 Basal bodies, kinocilia and planar cell polarity. Nat. Genet. 40, 10-11. (doi:10.1038/ng0108-10)
    • (2008) Nat. Genet , vol.40 , pp. 10-11
    • Axelrod, J.D.1
  • 84
    • 74749085823 scopus 로고    scopus 로고
    • Secreted frizzled-related protein disrupts PCP in eye lens fiber cells that have polarised primary cilia
    • (doi:10.1016/j.ydbio. 2009.11.033)
    • Sugiyama, Y., Stump, R. J., Nguyen, A., Wen, L., Chen, Y., Wang, Y., Murdoch, J. N., Lovicu, F. J. & McAvoy, J. W. 2010 Secreted frizzled-related protein disrupts PCP in eye lens fiber cells that have polarised primary cilia. Dev. Biol. 338, 193-201. (doi:10.1016/j.ydbio. 2009.11.033)
    • (2010) Dev. Biol , vol.338 , pp. 193-201
    • Sugiyama, Y.1    Stump, R.J.2    Nguyen, A.3    Wen, L.4    Chen, Y.5    Wang, Y.6    Murdoch, J.N.7    Lovicu, F.J.8    McAvoy, J.W.9
  • 85
    • 33846396811 scopus 로고    scopus 로고
    • Frizzled/PCP signalling: A conserved mechanism regulating cell polarity and directed motility
    • (doi:10. 1038/nrg2042)
    • Seifert, J. R. & Mlodzik, M. 2007 Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility. Nat. Rev. Genet. 8, 126-138. (doi:10. 1038/nrg2042)
    • (2007) Nat. Rev. Genet , vol.8 , pp. 126-138
    • Seifert, J.R.1    Mlodzik, M.2
  • 86
    • 53249127043 scopus 로고    scopus 로고
    • The planar polarity pathway
    • (doi:10.1016/j.cub.2008.07.055)
    • Strutt, D. 2008 The planar polarity pathway. Curr. Biol. 18, R898-R902. (doi:10.1016/j.cub.2008.07.055)
    • (2008) Curr. Biol , vol.18
    • Strutt, D.1
  • 87
    • 33646941288 scopus 로고    scopus 로고
    • Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals
    • (doi:10.1523/JNEUROSCI.4680-05.2006)
    • Montcouquiol, M. et al. 2006 Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals. J. Neurosci. 26, 5265-5275. (doi:10.1523/JNEUROSCI.4680-05.2006)
    • (2006) J. Neurosci , vol.26 , pp. 5265-5275
    • Montcouquiol, M.1
  • 88
    • 33645637038 scopus 로고    scopus 로고
    • The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells
    • (doi:10.1523/JNEUROSCI. 4698-05.2005)
    • Wang, Y., Guo, N. & Nathans, J. 2006 The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells. J. Neurosci. 26, 2147-2156. (doi:10.1523/JNEUROSCI. 4698-05.2005)
    • (2006) J. Neurosci , vol.26 , pp. 2147-2156
    • Wang, Y.1    Guo, N.2    Nathans, J.3
  • 89
    • 61349177856 scopus 로고    scopus 로고
    • Jagged 1 is necessary for normal mouse lens formation
    • (doi:10.1016/j.ydbio.2009.01.015)
    • Le, T. T., Conley, K. W. & Brown, N. L. 2009 Jagged 1 is necessary for normal mouse lens formation. Dev. Biol. 328, 118-126. (doi:10.1016/j.ydbio.2009.01.015)
    • (2009) Dev. Biol , vol.328 , pp. 118-126
    • Le, T.T.1    Conley, K.W.2    Brown, N.L.3
  • 90
    • 67649853093 scopus 로고    scopus 로고
    • Notch signaling is required for lateral induction of Jagged1 during FGF-induced lens fiber differentiation
    • (doi:10.1016/j.ydbio.2009. 05.566)
    • Saravanamuthu, S. S., Gao, C. Y. & Zelenka, P. S. 2009 Notch signaling is required for lateral induction of Jagged1 during FGF-induced lens fiber differentiation. Dev. Biol. 332, 166-176. (doi:10.1016/j.ydbio.2009. 05.566)
    • (2009) Dev. Biol , vol.332 , pp. 166-176
    • Saravanamuthu, S.S.1    Gao, C.Y.2    Zelenka, P.S.3
  • 91
    • 35148838929 scopus 로고    scopus 로고
    • The Notch signaling pathway controls the size of the ocular lens by directly suppressing p57Kip2 expression
    • (doi:10.1128/MCB. 00780-07)
    • Jia, J., Lin, M., Zhang, L., York, J. P. & Zhang, P. 2007 The Notch signaling pathway controls the size of the ocular lens by directly suppressing p57Kip2 expression. Mol. Cell. Biol. 27, 7236-7247. (doi:10.1128/MCB. 00780-07)
    • (2007) Mol. Cell. Biol , vol.27 , pp. 7236-7247
    • Jia, J.1    Lin, M.2    Zhang, L.3    York, J.P.4    Zhang, P.5
  • 92
    • 49249137030 scopus 로고    scopus 로고
    • Notch signaling regulates growth and differentiation in the mammalian lens
    • (doi:10.1016/j.ydbio. 2008.06.002)
    • Rowan, S., Conley, K. W., Le, T. T., Donner, A. L., Maas, R. L. & Brown, N. L. 2008 Notch signaling regulates growth and differentiation in the mammalian lens. Dev. Biol. 321, 111-122. (doi:10.1016/j.ydbio. 2008.06.002)
    • (2008) Dev. Biol , vol.321 , pp. 111-122
    • Rowan, S.1    Conley, K.W.2    Le, T.T.3    Donner, A.L.4    Maas, R.L.5    Brown, N.L.6
  • 94
    • 66749121943 scopus 로고    scopus 로고
    • Mutations of the EPHA2 receptor tyrosine kinase gene cause autosomal dominant congenital cataract
    • (doi:10. 1002/humu.20995)
    • Zhang, T. et al. 2009 Mutations of the EPHA2 receptor tyrosine kinase gene cause autosomal dominant congenital cataract. Hum. Mutat. 30, E603-E611. (doi:10. 1002/humu.20995)
    • (2009) Hum. Mutat , vol.30
    • Zhang, T.1
  • 95
    • 68249120153 scopus 로고    scopus 로고
    • EPHA2 is associated with age-related cortical cataract in mice and humans
    • (doi:10.1371/journal.pgen.1000584)
    • Jun, G. et al. 2009 EPHA2 is associated with age-related cortical cataract in mice and humans. PLoS Genet. 5, e1000584. (doi:10.1371/journal.pgen.1000584)
    • (2009) PLoS Genet , vol.5
    • Jun, G.1
  • 96
    • 55949135635 scopus 로고    scopus 로고
    • Loss of ephrin-A5 function disrupts lens fiber cell packing and leads to cataract
    • (doi:10.1073/pnas.0808987105)
    • Cooper, M. A., Son, A. I., Komlos, D., Sun, Y., Kleiman, N. J. & Zhou, R. 2008 Loss of ephrin-A5 function disrupts lens fiber cell packing and leads to cataract. Proc. Natl Acad. Sci. USA 105, 16 620-16 625. (doi:10.1073/pnas.0808987105)
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 16620-16625
    • Cooper, M.A.1    Son, A.I.2    Komlos, D.3    Sun, Y.4    Kleiman, N.J.5    Zhou, R.6
  • 97
    • 79960628802 scopus 로고    scopus 로고
    • The lens as a model for fibrotic disease
    • (doi:10.1098/rstb.2010.0341)
    • Eldred, J. A., Dawes, L. J. & Wormstone, I.M. 2011 The lens as a model for fibrotic disease. Phil. Trans. R. Soc. B 366, 1301-1319. (doi:10.1098/rstb.2010.0341)
    • (2011) Phil. Trans. R. Soc. B , vol.366 , pp. 1301-1319
    • Eldred, J.A.1    Dawes, L.J.2    Wormstone, I.M.3
  • 99
    • 0034312313 scopus 로고    scopus 로고
    • Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye
    • (doi:10.1101/gad.184000)
    • Ashery-Padan, R., Marquardt, T., Zhou, X. & Gruss, P. 2000 Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye. Genes Dev. 14, 2701-2711. (doi:10.1101/gad.184000)
    • (2000) Genes Dev , vol.14 , pp. 2701-2711
    • Ashery-Padan, R.1    Marquardt, T.2    Zhou, X.3    Gruss, P.4
  • 100
    • 70350389854 scopus 로고    scopus 로고
    • The type I BMP receptors, Bmpr1a and Acvr1, activate multiple signaling pathways to regulate lens formation
    • (doi:10.1016/j.ydbio.2009.08.027)
    • Rajagopal, R. et al. 2009 The type I BMP receptors, Bmpr1a and Acvr1, activate multiple signaling pathways to regulate lens formation. Dev. Biol. 335, 305-316. (doi:10.1016/j.ydbio.2009.08.027)
    • (2009) Dev. Biol , vol.335 , pp. 305-316
    • Rajagopal, R.1
  • 101
    • 56149096727 scopus 로고    scopus 로고
    • Functions of the type 1 BMP receptor Acvr1 (Alk2) in lens development: Cell proliferation, terminal differentiation, and survival
    • (doi:10. 1167/iovs.08-2217)
    • Rajagopal, R., Dattilo, L. K., Kaartinen, V., Deng, C. X., Umans, L., Zwijsen, A., Roberts, A. B., Bottinger, E. P. & Beebe, D. C. 2008 Functions of the type 1 BMP receptor Acvr1 (Alk2) in lens development: cell proliferation, terminal differentiation, and survival. Invest. Ophthalmol. Vis. Sci. 49, 4953-4960. (doi:10. 1167/iovs.08-2217)
    • (2008) Invest. Ophthalmol. Vis. Sci , vol.49 , pp. 4953-4960
    • Rajagopal, R.1    Dattilo, L.K.2    Kaartinen, V.3    Deng, C.X.4    Umans, L.5    Zwijsen, A.6    Roberts, A.B.7    Bottinger, E.P.8    Beebe, D.C.9
  • 103
    • 0036234299 scopus 로고    scopus 로고
    • Wnt-6 is expressed in the ureter bud and induces kidney tubule development in vitro
    • (doi:10.1002/gene.10079)
    • Itaranta, P., Lin, Y., Perasaari, J., Roel, G., Destree, O. & Vainio, S. 2002 Wnt-6 is expressed in the ureter bud and induces kidney tubule development in vitro. Genesis 32, 259-268. (doi:10.1002/gene.10079)
    • (2002) Genesis , vol.32 , pp. 259-268
    • Itaranta, P.1    Lin, Y.2    Perasaari, J.3    Roel, G.4    Destree, O.5    Vainio, S.6
  • 104
    • 0031690260 scopus 로고    scopus 로고
    • Wnt-7a maintains appropriate uterine patterning during the development of the mouse female reproductive tract
    • Miller, C. & Sassoon, D. A. 1998 Wnt-7a maintains appropriate uterine patterning during the development of the mouse female reproductive tract. Development 125, 3201-3211.
    • (1998) Development , vol.125 , pp. 3201-3211
    • Miller, C.1    Sassoon, D.A.2
  • 105
    • 19544375032 scopus 로고    scopus 로고
    • Wnt control of stem cells and differentiation in the intestinal epithelium
    • (doi:10.1016/j.yexcr. 2005.02.022)
    • Pinto, D. & Clevers, H. 2005 Wnt control of stem cells and differentiation in the intestinal epithelium. Exp. Cell Res. 306, 357-363. (doi:10.1016/j.yexcr. 2005.02.022)
    • (2005) Exp. Cell Res , vol.306 , pp. 357-363
    • Pinto, D.1    Clevers, H.2
  • 106
    • 0033036057 scopus 로고    scopus 로고
    • Analysis of chicken Wnt-13 expression demonstrates coincidence with cell division in the developing eye and is consistent with a role in induction
    • (doi:10.1002/(SICI)1097-0177 (199907)215:3, 215::AID-AJA4.3.0.CO;2-W)
    • Jasoni, C., Hendrickson, A. & Roelink, H. 1999 Analysis of chicken Wnt-13 expression demonstrates coincidence with cell division in the developing eye and is consistent with a role in induction. Dev. Dyn. 215, 215-224. (doi:10.1002/(SICI)1097-0177(199907)215:3, 215::AID-AJA4.3.0.CO;2-W)
    • (1999) Dev. Dyn , vol.215 , pp. 215-224
    • Jasoni, C.1    Hendrickson, A.2    Roelink, H.3
  • 107
    • 0034192018 scopus 로고    scopus 로고
    • Characterization of avian frizzled genes in cranial placode development
    • (doi:10. 1016/S0925-4773 (00)00263-X)
    • Stark, M. R., Biggs, J. J., Schoenwolf, G. C. & Rao, M. S. 2000 Characterization of avian frizzled genes in cranial placode development. Mech. Dev. 93, 195-200. (doi:10. 1016/S0925-4773(00)00263-X)
    • (2000) Mech. Dev , vol.93 , pp. 195-200
    • Stark, M.R.1    Biggs, J.J.2    Schoenwolf, G.C.3    Rao, M.S.4
  • 108
    • 0032122460 scopus 로고    scopus 로고
    • Developmental expression patterns of mouse sFRP genes encoding members of the secreted frizzled related protein family
    • (doi:10.1016/ S0925-4773 (98)00072-0)
    • Leimeister, C., Bach, A. & Gessler, M. 1998 Developmental expression patterns of mouse sFRP genes encoding members of the secreted frizzled related protein family. Mech. Dev. 75, 29-42. (doi:10.1016/ S0925-4773(98)00072-0)
    • (1998) Mech. Dev , vol.75 , pp. 29-42
    • Leimeister, C.1    Bach, A.2    Gessler, M.3
  • 109
    • 0038381600 scopus 로고    scopus 로고
    • A role for Wnt/beta-catenin signaling in lens epithelial differentiation
    • (doi:10.1016/S0012-1606 (03)00179-9)
    • Stump, R. J. et al. 2003 A role for Wnt/beta-catenin signaling in lens epithelial differentiation. Dev. Biol. 259, 48-61. (doi:10.1016/S0012-1606(03)00179-9)
    • (2003) Dev. Biol , vol.259 , pp. 48-61
    • Stump, R.J.1
  • 110
    • 33744468781 scopus 로고    scopus 로고
    • WNT/Frizzled signaling in eye development and disease
    • (doi:10.2741/1982)
    • de Iongh, R. U., Abud, H. E. & Hime, G. R. 2006 WNT/Frizzled signaling in eye development and disease. Front. Biosci. 11, 2442-2464. (doi:10.2741/1982)
    • (2006) Front. Biosci , vol.11 , pp. 2442-2464
    • de Iongh, R.U.1    Abud, H.E.2    Hime, G.R.3
  • 111
    • 79960651168 scopus 로고    scopus 로고
    • The lens: A classical model of embryonic induction providing new insights into cell determination in early development
    • (doi:10.1098/rstb.2010.0175)
    • Gunhaga, L. 2011 The lens: a classical model of embryonic induction providing new insights into cell determination in early development. Phil. Trans. R. Soc. B 366, 1193-1203. (doi:10.1098/rstb.2010.0175)
    • (2011) Phil. Trans. R. Soc. B , vol.366 , pp. 1193-1203
    • Gunhaga, L.1
  • 112
    • 25844490866 scopus 로고    scopus 로고
    • The duality of beta-catenin function: A requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm
    • (doi:10.1016/j.ydbio.2005.07.019)
    • Smith, A. N., Miller, L. A., Song, N., Taketo, M. M. & Lang, R. A. 2005 The duality of beta-catenin function: a requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm. Dev. Biol. 285, 477-489. (doi:10.1016/j.ydbio.2005.07.019)
    • (2005) Dev. Biol , vol.285 , pp. 477-489
    • Smith, A.N.1    Miller, L.A.2    Song, N.3    Taketo, M.M.4    Lang, R.A.5
  • 115
    • 17144376726 scopus 로고    scopus 로고
    • Noncanonical Wnt-4 signaling and EAF2 are required for eye development in Xenopus laevis
    • (doi:10. 1038/sj.emboj.7600603)
    • Maurus, D., Heligon, C., Burger-Schwarzler, A., Brandli, A. W. & Kuhl, M. 2005 Noncanonical Wnt-4 signaling and EAF2 are required for eye development in Xenopus laevis. EMBO J. 24, 1181-1191. (doi:10. 1038/sj.emboj.7600603)
    • (2005) EMBO J , vol.24 , pp. 1181-1191
    • Maurus, D.1    Heligon, C.2    Burger-Schwarzler, A.3    Brandli, A.W.4    Kuhl, M.5
  • 116
    • 0032815025 scopus 로고    scopus 로고
    • Spatial and temporal expression of p57(KIP2) during murine lens development
    • (doi:10.1016/ S0925-4773 (99)00106-9)
    • Lovicu, F. J. & McAvoy, J. W. 1999 Spatial and temporal expression of p57(KIP2) during murine lens development. Mech. Dev. 86, 165-169. (doi:10.1016/ S0925-4773(99)00106-9)
    • (1999) Mech. Dev , vol.86 , pp. 165-169
    • Lovicu, F.J.1    McAvoy, J.W.2
  • 117
    • 0033616621 scopus 로고    scopus 로고
    • Requirement for the c-Maf transcription factor in crystallin gene regulation and lens development
    • (doi:10.1073/pnas.96.7.3781)
    • Kim, J. I., Li, T., Ho, I. C., Grusby, M. J. & Glimcher, L. H. 1999 Requirement for the c-Maf transcription factor in crystallin gene regulation and lens development. Proc. Natl Acad. Sci. USA 96, 3781-3785. (doi:10.1073/pnas.96.7.3781)
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 3781-3785
    • Kim, J.I.1    Li, T.2    Ho, I.C.3    Grusby, M.J.4    Glimcher, L.H.5
  • 118
    • 0142169857 scopus 로고    scopus 로고
    • Proteome analysis of lens epithelia, fibers, and the HLE B-3 cell line
    • (doi:10.1167/ iovs.03-0556)
    • Wang-Su, S. T. et al. 2003 Proteome analysis of lens epithelia, fibers, and the HLE B-3 cell line. Invest. Ophthalmol. Vis. Sci. 44, 4829-4836. (doi:10.1167/ iovs.03-0556)
    • (2003) Invest. Ophthalmol. Vis. Sci , vol.44 , pp. 4829-4836
    • Wang-Su, S.T.1
  • 119
    • 33750415021 scopus 로고    scopus 로고
    • Vitronectin is present in epithelial cells of the intact lens and promotes epithelial mesenchymal transition in lens epithelial explants
    • Taliana, L., Evans, M. D., Ang, S. & McAvoy, J. W. 2006 Vitronectin is present in epithelial cells of the intact lens and promotes epithelial mesenchymal transition in lens epithelial explants. Mol. Vis. 12, 1233-1242.
    • (2006) Mol. Vis , vol.12 , pp. 1233-1242
    • Taliana, L.1    Evans, M.D.2    Ang, S.3    McAvoy, J.W.4
  • 120
    • 77249159483 scopus 로고    scopus 로고
    • Epithelial explants and their application to study development processes in the lens
    • In, (ed. P. A. Tsonis), San Diego, CA: Academic Press
    • Lovicu, F. J. & McAvoy, J. W. 2008 Epithelial explants and their application to study development processes in the lens. In Animal models in eye research (ed. P. A. Tsonis), pp. 134-147. San Diego, CA: Academic Press.
    • (2008) Animal models in eye research , pp. 134-147
    • Lovicu, F.J.1    McAvoy, J.W.2
  • 121
    • 33846342950 scopus 로고    scopus 로고
    • Extracellular matrix and integrin signaling in lens development and cataract
    • (doi:10. 1016/j.semcdb.2006.10.006)
    • Wederell, E. D. & de Iongh, R. U. 2006 Extracellular matrix and integrin signaling in lens development and cataract. Semin. Cell Dev. Biol. 17, 759-776. (doi:10. 1016/j.semcdb.2006.10.006)
    • (2006) Semin. Cell Dev. Biol , vol.17 , pp. 759-776
    • Wederell, E.D.1    de Iongh, R.U.2
  • 122
    • 0032587606 scopus 로고    scopus 로고
    • Synergistic activities of alpha3 and alpha6 integrins are required during apical ectodermal ridge formation and organogenesis in the mouse
    • De Arcangelis, A., Mark, M., Kreidberg, J., Sorokin, L. & Georges-Labouesse, E. 1999 Synergistic activities of alpha3 and alpha6 integrins are required during apical ectodermal ridge formation and organogenesis in the mouse. Development 126, 3957-3968.
    • (1999) Development , vol.126 , pp. 3957-3968
    • de Arcangelis, A.1    Mark, M.2    Kreidberg, J.3    Sorokin, L.4    Georges-Labouesse, E.5
  • 123
    • 84867259404 scopus 로고    scopus 로고
    • The effect of conditional null mutation of integrin-linked kinase (Ilk) on lens development
    • ARVO Meeting Abstracts, Fort Lauderdale, FL, April 27-May 1, 2008
    • de Iongh, R. U., Teo, Z. L., Dedhar, S. & Robinson, M. L. 2008 The effect of conditional null mutation of integrin-linked kinase (Ilk) on lens development. ARVO Meeting Abstracts, Fort Lauderdale, FL, April 27-May 1, 2008. Invest. Ophthalmol. Vis. Sci. 49, 5406.
    • (2008) Invest. Ophthalmol. Vis. Sci , vol.49 , pp. 5406
    • de Iongh, R.U.1    Teo, Z.L.2    Dedhar, S.3    Robinson, M.L.4
  • 124
    • 34249879299 scopus 로고    scopus 로고
    • Conditional deletion of beta1-integrin from the developing lens leads to loss of the lens epithelial phenotype
    • (doi:10.1016/j.ydbio.2007.04.004)
    • Simirskii, V. N., Wang, Y. & Duncan, M. K. 2007 Conditional deletion of beta1-integrin from the developing lens leads to loss of the lens epithelial phenotype. Dev. Biol. 306, 658-668. (doi:10.1016/j.ydbio.2007.04.004)
    • (2007) Dev. Biol , vol.306 , pp. 658-668
    • Simirskii, V.N.1    Wang, Y.2    Duncan, M.K.3
  • 125
    • 85020757479 scopus 로고    scopus 로고
    • Integrin linked kinase (ILK) is required for lens epithelial cell survival and proliferation
    • In, for Eye Research, Montreal, Canada, 18-23 July 2010 abstract 509
    • Teo, J., McQueen-Miscamble, L., Turner, K., Martinez, G., Reneker, L., Dedhar, S., Robinson, M. & de Iongh, R. 2010 Integrin linked kinase (ILK) is required for lens epithelial cell survival and proliferation. In XIX Biennal Meeting of Int. Soc. for Eye Research, Montreal, Canada, 18-23 July 2010, abstract 509. (http://www. kenes.com/iser2010/cd/Index.htm).
    • (2010) XIX Biennal Meeting of Int. Soc
    • Teo, J.1    McQueen-Miscamble, L.2    Turner, K.3    Martinez, G.4    Reneker, L.5    Dedhar, S.6    Robinson, M.7    de Iongh, R.8
  • 126
    • 0025583489 scopus 로고
    • Growth factors in the eye
    • (doi:10.1016/0955-2235 (90)90008-8)
    • McAvoy, J. W. & Chamberlain, C. G. 1990 Growth factors in the eye. Prog. Growth Factor Res. 2, 29-43. (doi:10.1016/0955-2235(90)90008-8)
    • (1990) Prog. Growth Factor Res , vol.2 , pp. 29-43
    • McAvoy, J.W.1    Chamberlain, C.G.2
  • 127
    • 0036290891 scopus 로고    scopus 로고
    • Influence of platelet-derived growth factor on lens epithelial cell proliferation and differentiation
    • (doi:10.1080/ 08977190290022202)
    • Kok, A., Lovicu, F. J., Chamberlain, C. G. & McAvoy, J. W. 2002 Influence of platelet-derived growth factor on lens epithelial cell proliferation and differentiation. Growth Factors 20, 27-34. (doi:10.1080/ 08977190290022202)
    • (2002) Growth Factors , vol.20 , pp. 27-34
    • Kok, A.1    Lovicu, F.J.2    Chamberlain, C.G.3    McAvoy, J.W.4
  • 128
    • 14844327988 scopus 로고    scopus 로고
    • Platelet-derived growth factor D, tissue-specific expression in the eye, and a key role in control of lens epithelial cell proliferation
    • (doi:10.1074/ jbc.M413570200)
    • Ray, S., Gao, C., Wyatt, K., Fariss, R. N., Bundek, A., Zelenka, P. & Wistow, G. 2005 Platelet-derived growth factor D, tissue-specific expression in the eye, and a key role in control of lens epithelial cell proliferation. J. Biol. Chem. 280, 8494-8502. (doi:10.1074/ jbc.M413570200)
    • (2005) J. Biol. Chem , vol.280 , pp. 8494-8502
    • Ray, S.1    Gao, C.2    Wyatt, K.3    Fariss, R.N.4    Bundek, A.5    Zelenka, P.6    Wistow, G.7
  • 129
    • 0027417037 scopus 로고
    • Regulation of lens cell growth and polarity by an embryo-specific growth factor and by inhibitors of lens cell proliferation and differentiation
    • Hyatt, G. A. & Beebe, D. C. 1993 Regulation of lens cell growth and polarity by an embryo-specific growth factor and by inhibitors of lens cell proliferation and differentiation. Development 117, 701-709.
    • (1993) Development , vol.117 , pp. 701-709
    • Hyatt, G.A.1    Beebe, D.C.2
  • 130
    • 3242883871 scopus 로고    scopus 로고
    • Hepatocyte growth factor induces proliferation of lens epithelial cells through activation of ERK1/2 and JNK/SAPK
    • (doi:10. 1167/iovs.03-1371)
    • Choi, J., Park, S. Y. & Joo, C. K. 2004 Hepatocyte growth factor induces proliferation of lens epithelial cells through activation of ERK1/2 and JNK/SAPK. Invest. Ophthalmol. Vis. Sci. 45, 2696-2704. (doi:10. 1167/iovs.03-1371)
    • (2004) Invest. Ophthalmol. Vis. Sci , vol.45 , pp. 2696-2704
    • Choi, J.1    Park, S.Y.2    Joo, C.K.3
  • 131
    • 0033653008 scopus 로고    scopus 로고
    • Hepatocyte growth factor function and c-Met expression in human lens epithelial cells
    • Wormstone, I. M., Tamiya, S., Marcantonio, J. M. & Reddan, J. R. 2000 Hepatocyte growth factor function and c-Met expression in human lens epithelial cells. Invest. Ophthalmol. Vis. Sci. 41, 4216-4222.
    • (2000) Invest. Ophthalmol. Vis. Sci , vol.41 , pp. 4216-4222
    • Wormstone, I.M.1    Tamiya, S.2    Marcantonio, J.M.3    Reddan, J.R.4
  • 132
    • 0028197565 scopus 로고
    • Effect of plateletderived growth factor PDGF on replication of cultivated bovine lens epithelial cells
    • Wunderlich, K. & Knorr, M. 1994 Effect of plateletderived growth factor PDGF on replication of cultivated bovine lens epithelial cells. Ophthalmology 91, 98-102.
    • (1994) Ophthalmology , vol.91 , pp. 98-102
    • Wunderlich, K.1    Knorr, M.2
  • 133
    • 0020576898 scopus 로고
    • Insulin growth factor and epidermal growth factor trigger mitosis in lenses cultured in a serum-free medium
    • Reddan, J. R. & Wilson-Dziedzic, D. 1983 Insulin growth factor and epidermal growth factor trigger mitosis in lenses cultured in a serum-free medium. Invest. Ophthalmol. Vis. Sci. 24, 409-416.
    • (1983) Invest. Ophthalmol. Vis. Sci , vol.24 , pp. 409-416
    • Reddan, J.R.1    Wilson-Dziedzic, D.2
  • 134
    • 58149133635 scopus 로고    scopus 로고
    • Growth factors involved in aqueous humour-induced lens cell proliferation
    • (doi:10.1080/08977190802610916)
    • Iyengar, L., Patkunanathan, B., McAvoy, J. W. & Lovicu, F. J. 2009 Growth factors involved in aqueous humour-induced lens cell proliferation. Growth Factors 27, 50-62. (doi:10.1080/08977190802610916)
    • (2009) Growth Factors , vol.27 , pp. 50-62
    • Iyengar, L.1    Patkunanathan, B.2    McAvoy, J.W.3    Lovicu, F.J.4
  • 135
    • 33846357137 scopus 로고    scopus 로고
    • Sef and Sprouty expression in the developing ocular lens: Implications for regulating lens cell proliferation and differentiation
    • (doi:10.1016/j.semcdb.2006.10.007)
    • Boros, J., Newitt, P., Wang, Q., McAvoy, J.W. & Lovicu, F. J. 2006 Sef and Sprouty expression in the developing ocular lens: implications for regulating lens cell proliferation and differentiation. Semin. Cell Dev. Biol. 17, 741-752. (doi:10.1016/j.semcdb.2006.10.007)
    • (2006) Semin. Cell Dev. Biol , vol.17 , pp. 741-752
    • Boros, J.1    Newitt, P.2    Wang, Q.3    McAvoy, J.W.4    Lovicu, F.J.5
  • 136
    • 84867262507 scopus 로고    scopus 로고
    • Spreds: Sprouty-related proteins antagonistic for multiple cell signalling pathways are expressed in the lens and eye
    • ARVO Meeting Abstracts, Fort Lauderdale, FL, May 3-7, 2009
    • Lovicu, F. J., Boros, J. & McAvoy, J. W. 2009 Spreds: sprouty-related proteins antagonistic for multiple cell signalling pathways are expressed in the lens and eye. ARVO Meeting Abstracts, Fort Lauderdale, FL, May 3-7, 2009. Invest. Ophthalmol. Vis. Sci. 50, 4353.
    • (2009) Invest. Ophthalmol. Vis. Sci , vol.50 , pp. 4353
    • Lovicu, F.J.1    Boros, J.2    McAvoy, J.W.3
  • 137
    • 17044423052 scopus 로고    scopus 로고
    • Synergistic activity of Sef and Sprouty proteins in regulating the expression of Gbx2 in the mid-hindbrain region
    • (doi:10.1002/gene.20103)
    • Lin, W., Jing, N., Basson, M. A., Dierich, A. E., Licht, L. & Ang, S.-L. 2005 Synergistic activity of Sef and Sprouty proteins in regulating the expression of Gbx2 in the mid-hindbrain region. Genesis 41, 110-115. (doi:10.1002/gene.20103)
    • (2005) Genesis , vol.41 , pp. 110-115
    • Lin, W.1    Jing, N.2    Basson, M.A.3    Dierich, A.E.4    Licht, L.5    Ang, S.-L.6
  • 138
    • 77954215605 scopus 로고    scopus 로고
    • Sef is a negative regulator of fiber cell differentiation in the ocular lens
    • (doi:10.1016/j.diff.2010.05.005)
    • Newitt, P., Boros, J., Madakashira, B., Robinson, M. L., Reneker, L. W., McAvoy, J. W. & Lovicu, F. J. 2010 Sef is a negative regulator of fiber cell differentiation in the ocular lens. Differentiation 80, 53-67. (doi:10.1016/j.diff.2010.05.005)
    • (2010) Differentiation , vol.80 , pp. 53-67
    • Newitt, P.1    Boros, J.2    Madakashira, B.3    Robinson, M.L.4    Reneker, L.W.5    McAvoy, J.W.6    Lovicu, F.J.7
  • 139
    • 48949116179 scopus 로고    scopus 로고
    • Know thy Sef: A novel class of feedback antagonists of receptor tyrosine kinase signaling
    • (doi:10.1016/j.biocel.2008.03.013)
    • Ron, D., Fuchs, Y. & Chorev, D. S. 2008 Know thy Sef: a novel class of feedback antagonists of receptor tyrosine kinase signaling. Int. J. Biochem. Cell Biol. 40, 2040-2052. (doi:10.1016/j.biocel.2008.03.013)
    • (2008) Int. J. Biochem. Cell Biol , vol.40 , pp. 2040-2052
    • Ron, D.1    Fuchs, Y.2    Chorev, D.S.3


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