-
1
-
-
0019829568
-
The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today
-
Doll R, Peto R. The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst (1981) 66:1191-308.
-
(1981)
J Natl Cancer Inst
, vol.66
, pp. 1191-1308
-
-
Doll, R.1
Peto, R.2
-
2
-
-
0142166328
-
Cancer chemoprevention with dietary phytochemicals
-
doi:10.1038/nrc1189
-
Surh YJ. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer (2003) 3:768-80. doi:10.1038/nrc1189
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 768-780
-
-
Surh, Y.J.1
-
3
-
-
0037248328
-
Cancer prevention-the potential for diet to modulate molecular signalling
-
doi:10.1016/S1471-4914(02)00002-3
-
Manson MM. Cancer prevention-the potential for diet to modulate molecular signalling. Trends Mol Med (2003) 9:11-8. doi:10.1016/S1471-4914(02)00002-3
-
(2003)
Trends Mol Med
, vol.9
, pp. 11-18
-
-
Manson, M.M.1
-
4
-
-
0034668148
-
Cell signaling and regulators of cell cycle as molecular targets for prostate cancer prevention by dietary agents
-
doi:10.1016/S0006-2952(00)00385-3
-
Agarwal R. Cell signaling and regulators of cell cycle as molecular targets for prostate cancer prevention by dietary agents. Biochem Pharmacol (2000) 60:1051-9. doi:10.1016/S0006-2952(00)00385-3
-
(2000)
Biochem Pharmacol
, vol.60
, pp. 1051-1059
-
-
Agarwal, R.1
-
5
-
-
0028839008
-
Diet, signal transduction and carcinogenesis
-
Ashendel CL. Diet, signal transduction and carcinogenesis. J Nutr (1995) 125:686S-91.
-
(1995)
J Nutr
, vol.125
-
-
Ashendel, C.L.1
-
6
-
-
0031930629
-
Suppression of tumour development by substances derived from the diet-mechanisms and clinical implications
-
doi:10.1046/j.1365-2125.1998.00640.x
-
Gescher A, Pastorino U, Plummer SM, Manson MM. Suppression of tumour development by substances derived from the diet-mechanisms and clinical implications. Br J Clin Pharmacol (1998) 45:1-12. doi:10.1046/j.1365-2125.1998.00640.x
-
(1998)
Br J Clin Pharmacol
, vol.45
, pp. 1-12
-
-
Gescher, A.1
Pastorino, U.2
Plummer, S.M.3
Manson, M.M.4
-
7
-
-
0001497590
-
Signal transduction events elicited by cancer prevention compounds
-
Kong AN, Yu R, Hebbar V, Chen C, Owuor E, Hu R, et al. Signal transduction events elicited by cancer prevention compounds. Mutat Res (2001) 48(0-481):231-41.
-
(2001)
Mutat Res
, vol.48
, Issue.0-481
, pp. 231-241
-
-
Kong, A.N.1
Yu, R.2
Hebbar, V.3
Chen, C.4
Owuor, E.5
Hu, R.6
-
8
-
-
0034653353
-
Blocking and suppressing mechanisms of chemoprevention by dietary constituents
-
doi:10.1016/S0378-4274(99)00211-8
-
Manson MM, Gescher A, Hudson EA, Plummer SM, Squires MS, Prigent SA. Blocking and suppressing mechanisms of chemoprevention by dietary constituents. Toxicol Lett (2000) 11(2-113):499-505. doi:10.1016/S0378-4274(99)00211-8
-
(2000)
Toxicol Lett
, vol.11
, Issue.2-113
, pp. 499-505
-
-
Manson, M.M.1
Gescher, A.2
Hudson, E.A.3
Plummer, S.M.4
Squires, M.S.5
Prigent, S.A.6
-
9
-
-
84867411346
-
Adenosine monophosphate-activated protein kinase: a central regulator of metabolism with roles in diabetes, cancer, and viral infection
-
doi:10.1101/sqb.2011.76.010819
-
Hardie DG. Adenosine monophosphate-activated protein kinase: a central regulator of metabolism with roles in diabetes, cancer, and viral infection. Cold Spring Harb Symp Quant Biol (2011) 76:155-64. doi:10.1101/sqb.2011.76.010819
-
(2011)
Cold Spring Harb Symp Quant Biol
, vol.76
, pp. 155-164
-
-
Hardie, D.G.1
-
10
-
-
84858782079
-
AMPK: a nutrient and energy sensor that maintains energy homeostasis
-
doi:10.1038/nrm3311
-
Hardie DG, Ross FA, Hawley SA. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol (2012) 13:251-62. doi:10.1038/nrm3311
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 251-262
-
-
Hardie, D.G.1
Ross, F.A.2
Hawley, S.A.3
-
11
-
-
67650914230
-
AMPK in health and disease
-
doi:10.1152/physrev.00011.2008
-
Steinberg GR, Kemp BE. AMPK in health and disease. Physiol Rev (2009) 89:1025-78. doi:10.1152/physrev.00011.2008
-
(2009)
Physiol Rev
, vol.89
, pp. 1025-1078
-
-
Steinberg, G.R.1
Kemp, B.E.2
-
12
-
-
34648828532
-
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
-
doi:10.1038/nrm2249
-
Hardie DG. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol (2007) 8:774-85. doi:10.1038/nrm2249
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 774-785
-
-
Hardie, D.G.1
-
13
-
-
70449584566
-
AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply
-
doi:10.1073/pnas.0909873106
-
Hoppe S, Bierhoff H, Cado I, Weber A, Tiebe M, Grummt I, et al. AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply. Proc Natl Acad Sci U S A (2009) 106:17781-6. doi:10.1073/pnas.0909873106
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 17781-17786
-
-
Hoppe, S.1
Bierhoff, H.2
Cado, I.3
Weber, A.4
Tiebe, M.5
Grummt, I.6
-
14
-
-
0345107247
-
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
-
doi:10.1186/1475-4924-2-28
-
Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Makela TP, et al. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol (2003) 2:28. doi:10.1186/1475-4924-2-28
-
(2003)
J Biol
, vol.2
, pp. 28
-
-
Hawley, S.A.1
Boudeau, J.2
Reid, J.L.3
Mustard, K.J.4
Udd, L.5
Makela, T.P.6
-
15
-
-
10744230065
-
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade
-
doi:10.1016/j.cub.2003.10.031
-
Woods A, Johnstone SR, Dickerson K, Leiper FC, Fryer LG, Neumann D, et al. LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol (2003) 13:2004-8. doi:10.1016/j.cub.2003.10.031
-
(2003)
Curr Biol
, vol.13
, pp. 2004-2008
-
-
Woods, A.1
Johnstone, S.R.2
Dickerson, K.3
Leiper, F.C.4
Fryer, L.G.5
Neumann, D.6
-
16
-
-
0032495530
-
A serine/threonine kinase gene defective in Peutz-Jeghers syndrome
-
doi:10.1038/34432
-
Hemminki A, Markie D, Tomlinson I, Avizienyte E, Roth S, Loukola A, et al. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature (1998) 391:184-7. doi:10.1038/34432
-
(1998)
Nature
, vol.391
, pp. 184-187
-
-
Hemminki, A.1
Markie, D.2
Tomlinson, I.3
Avizienyte, E.4
Roth, S.5
Loukola, A.6
-
17
-
-
0036645286
-
Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung
-
Sanchez-Cespedes M, Parrella P, Esteller M, Nomoto S, Trink B, Engles JM, et al. Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Cancer Res (2002) 62:3659-62.
-
(2002)
Cancer Res
, vol.62
, pp. 3659-3662
-
-
Sanchez-Cespedes, M.1
Parrella, P.2
Esteller, M.3
Nomoto, S.4
Trink, B.5
Engles, J.M.6
-
18
-
-
23044432463
-
Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase
-
doi:10.1016/j.cmet.2005.05.009
-
Hawley SA, Pan DA, Mustard KJ, Ross L, Bain J, Edelman AM, et al. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab (2005) 2:9-19. doi:10.1016/j.cmet.2005.05.009
-
(2005)
Cell Metab
, vol.2
, pp. 9-19
-
-
Hawley, S.A.1
Pan, D.A.2
Mustard, K.J.3
Ross, L.4
Bain, J.5
Edelman, A.M.6
-
19
-
-
23844471263
-
The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases
-
doi:10.1074/jbc.M503824200
-
Hurley RL, Anderson KA, Franzone JM, Kemp BE, Means AR, Witters LA. The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases. J Biol Chem (2005) 280:29060-6. doi:10.1074/jbc.M503824200
-
(2005)
J Biol Chem
, vol.280
, pp. 29060-29066
-
-
Hurley, R.L.1
Anderson, K.A.2
Franzone, J.M.3
Kemp, B.E.4
Means, A.R.5
Witters, L.A.6
-
20
-
-
23044437445
-
Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells
-
doi:10.1016/j.cmet.2005.06.005
-
Woods A, Dickerson K, Heath R, Hong SP, Momcilovic M, Johnstone SR, et al. Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metab (2005) 2:21-33. doi:10.1016/j.cmet.2005.06.005
-
(2005)
Cell Metab
, vol.2
, pp. 21-33
-
-
Woods, A.1
Dickerson, K.2
Heath, R.3
Hong, S.P.4
Momcilovic, M.5
Johnstone, S.R.6
-
21
-
-
39049157916
-
Phosphatidylinositol ether lipid analogues induce AMP-activated protein kinase-dependent death in LKB1-mutant non small cell lung cancer cells
-
doi:10.1158/0008-5472.CAN-07-3091
-
Memmott RM, Gills JJ, Hollingshead M, Powers MC, Chen Z, Kemp B, et al. Phosphatidylinositol ether lipid analogues induce AMP-activated protein kinase-dependent death in LKB1-mutant non small cell lung cancer cells. Cancer Res (2008) 68:580-8. doi:10.1158/0008-5472.CAN-07-3091
-
(2008)
Cancer Res
, vol.68
, pp. 580-588
-
-
Memmott, R.M.1
Gills, J.J.2
Hollingshead, M.3
Powers, M.C.4
Chen, Z.5
Kemp, B.6
-
22
-
-
56049086590
-
Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro
-
doi:10.1016/j.taap.2008.08.013
-
Dykens JA, Jamieson J, Marroquin L, Nadanaciva S, Billis PA, Will Y. Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro. Toxicol Appl Pharmacol (2008) 233:203-10. doi:10.1016/j.taap.2008.08.013
-
(2008)
Toxicol Appl Pharmacol
, vol.233
, pp. 203-210
-
-
Dykens, J.A.1
Jamieson, J.2
Marroquin, L.3
Nadanaciva, S.4
Billis, P.A.5
Will, Y.6
-
23
-
-
28844433635
-
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
-
doi:10.1126/science.1120781
-
Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, et al. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science (2005) 310:1642-6. doi:10.1126/science.1120781
-
(2005)
Science
, vol.310
, pp. 1642-1646
-
-
Shaw, R.J.1
Lamia, K.A.2
Vasquez, D.3
Koo, S.H.4
Bardeesy, N.5
Depinho, R.A.6
-
24
-
-
77950191479
-
Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells
-
doi:10.1158/0008-5472.CAN-09-2782
-
Ben Sahra I, Laurent K, Giuliano S, Larbret F, Ponzio G, Gounon P, et al. Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells. Cancer Res (2010) 70:2465-75. doi:10.1158/0008-5472.CAN-09-2782
-
(2010)
Cancer Res
, vol.70
, pp. 2465-2475
-
-
Ben Sahra, I.1
Laurent, K.2
Giuliano, S.3
Larbret, F.4
Ponzio, G.5
Gounon, P.6
-
25
-
-
0034614420
-
Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I
-
doi:10.1074/jbc.275.1.223
-
El-Mir MY, Nogueira V, Fontaine E, Averet N, Rigoulet M, Leverve X. Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. J Biol Chem (2000) 275:223-8. doi:10.1074/jbc.275.1.223
-
(2000)
J Biol Chem
, vol.275
, pp. 223-228
-
-
El-Mir, M.Y.1
Nogueira, V.2
Fontaine, E.3
Averet, N.4
Rigoulet, M.5
Leverve, X.6
-
26
-
-
20444461067
-
Metformin and reduced risk of cancer in diabetic patients
-
doi:10.1136/bmj.38415.708634.F7
-
Evans JM, Donnelly LA, Emslie-Smith AM, Alessi DR, Morris AD. Metformin and reduced risk of cancer in diabetic patients. BMJ (2005) 330:1304-5. doi:10.1136/bmj.38415.708634.F7
-
(2005)
BMJ
, vol.330
, pp. 1304-1305
-
-
Evans, J.M.1
Donnelly, L.A.2
Emslie-Smith, A.M.3
Alessi, D.R.4
Morris, A.D.5
-
27
-
-
67749144226
-
Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer
-
doi:10.1200/JCO.2009.19.6410
-
Jiralerspong S, Palla SL, Giordano SH, Meric-Bernstam F, Liedtke C, Barnett CM, et al. Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer. J Clin Oncol (2009) 27:3297-302. doi:10.1200/JCO.2009.19.6410
-
(2009)
J Clin Oncol
, vol.27
, pp. 3297-3302
-
-
Jiralerspong, S.1
Palla, S.L.2
Giordano, S.H.3
Meric-Bernstam, F.4
Liedtke, C.5
Barnett, C.M.6
-
28
-
-
44449103256
-
Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice
-
doi:10.1042/BJ20080557
-
Huang X, Wullschleger S, Shpiro N, McGuire VA, Sakamoto K, Woods YL, et al. Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice. Biochem J (2008) 412:211-21. doi:10.1042/BJ20080557
-
(2008)
Biochem J
, vol.412
, pp. 211-221
-
-
Huang, X.1
Wullschleger, S.2
Shpiro, N.3
McGuire, V.A.4
Sakamoto, K.5
Woods, Y.L.6
-
29
-
-
77955917717
-
Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells
-
doi:10.1016/j.ijrobp.2010.03.005
-
Sanli T, Rashid A, Liu C, Harding S, Bristow RG, Cutz JC, et al. Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells. Int J Radiat Oncol Biol Phys (2010) 78:221-9. doi:10.1016/j.ijrobp.2010.03.005
-
(2010)
Int J Radiat Oncol Biol Phys
, vol.78
, pp. 221-229
-
-
Sanli, T.1
Rashid, A.2
Liu, C.3
Harding, S.4
Bristow, R.G.5
Cutz, J.C.6
-
30
-
-
84869837353
-
Direct AMP-activated protein kinase activators: a review of evidence from the patent literature
-
doi:10.1517/13543776.2012.743994
-
Giordanetto F, Karis D. Direct AMP-activated protein kinase activators: a review of evidence from the patent literature. Expert Opin Ther Pat (2012) 22:1467-77. doi:10.1517/13543776.2012.743994
-
(2012)
Expert Opin Ther Pat
, vol.22
, pp. 1467-1477
-
-
Giordanetto, F.1
Karis, D.2
-
31
-
-
79959389619
-
AMP-activated protein kinase modulators: a patent review (2006-2010)
-
doi:10.1517/13543776.2011.577069
-
Yun H, Ha J. AMP-activated protein kinase modulators: a patent review (2006-2010). Expert Opin Ther Pat (2011) 21:983-1005. doi:10.1517/13543776.2011.577069
-
(2011)
Expert Opin Ther Pat
, vol.21
, pp. 983-1005
-
-
Yun, H.1
Ha, J.2
-
32
-
-
82555166000
-
mTOR signaling in disease
-
doi:10.1016/j.ceb.2011.09.003
-
Dazert E, Hall MN. mTOR signaling in disease. Curr Opin Cell Biol (2011) 23:744-55. doi:10.1016/j.ceb.2011.09.003
-
(2011)
Curr Opin Cell Biol
, vol.23
, pp. 744-755
-
-
Dazert, E.1
Hall, M.N.2
-
33
-
-
0347716759
-
Rheb fills a GAP between TSC and TOR
-
doi:10.1016/j.tibs.2003.09.003
-
Manning BD, Cantley LC. Rheb fills a GAP between TSC and TOR. Trends Biochem Sci (2003) 28:573-6. doi:10.1016/j.tibs.2003.09.003
-
(2003)
Trends Biochem Sci
, vol.28
, pp. 573-576
-
-
Manning, B.D.1
Cantley, L.C.2
-
34
-
-
0035929359
-
Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line
-
doi:10.1006/bbrc.2001.5627
-
Imamura K, Ogura T, Kishimoto A, Kaminishi M, Esumi H. Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line. Biochem Biophys Res Commun (2001) 287:562-7. doi:10.1006/bbrc.2001.5627
-
(2001)
Biochem Biophys Res Commun
, vol.287
, pp. 562-567
-
-
Imamura, K.1
Ogura, T.2
Kishimoto, A.3
Kaminishi, M.4
Esumi, H.5
-
35
-
-
20844449238
-
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
-
doi:10.1016/j.molcel.2005.03.027
-
Jones RG, Plas DR, Kubek S, Buzzai M, Mu J, Xu Y, et al. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell (2005) 18:283-93. doi:10.1016/j.molcel.2005.03.027
-
(2005)
Mol Cell
, vol.18
, pp. 283-293
-
-
Jones, R.G.1
Plas, D.R.2
Kubek, S.3
Buzzai, M.4
Mu, J.5
Xu, Y.6
-
36
-
-
33947250696
-
The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis
-
doi:10.1038/ncb1537
-
Liang J, Shao SH, Xu ZX, Hennessy B, Ding Z, Larrea M, et al. The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol (2007) 9:218-24. doi:10.1038/ncb1537
-
(2007)
Nat Cell Biol
, vol.9
, pp. 218-224
-
-
Liang, J.1
Shao, S.H.2
Xu, Z.X.3
Hennessy, B.4
Ding, Z.5
Larrea, M.6
-
37
-
-
80052511813
-
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
-
doi:10.1038/ncb2329
-
Mihaylova MM, Shaw RJ. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol (2011) 13:1016-23. doi:10.1038/ncb2329
-
(2011)
Nat Cell Biol
, vol.13
, pp. 1016-1023
-
-
Mihaylova, M.M.1
Shaw, R.J.2
-
38
-
-
77955354069
-
AMPK-and p62/SQSTM1-dependent autophagy mediate Resveratrol-induced cell death in chronic myelogenous leukemia
-
doi:10.4161/auto.6.5.12126
-
Puissant A, Auberger P. AMPK-and p62/SQSTM1-dependent autophagy mediate Resveratrol-induced cell death in chronic myelogenous leukemia. Autophagy (2010) 6:655-7. doi:10.4161/auto.6.5.12126
-
(2010)
Autophagy
, vol.6
, pp. 655-657
-
-
Puissant, A.1
Auberger, P.2
-
39
-
-
77956402268
-
Targeting autophagy to fight hematopoietic malignancies
-
doi:10.4161/cc.9.17.13048
-
Puissant A, Robert G, Auberger P. Targeting autophagy to fight hematopoietic malignancies. Cell Cycle (2010) 9:3470-8. doi:10.4161/cc.9.17.13048
-
(2010)
Cell Cycle
, vol.9
, pp. 3470-3478
-
-
Puissant, A.1
Robert, G.2
Auberger, P.3
-
40
-
-
39849109338
-
Autophagy fights disease through cellular self-digestion
-
doi:10.1038/nature06639
-
Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature (2008) 451:1069-75. doi:10.1038/nature06639
-
(2008)
Nature
, vol.451
, pp. 1069-1075
-
-
Mizushima, N.1
Levine, B.2
Cuervo, A.M.3
Klionsky, D.J.4
-
41
-
-
0034683568
-
Tor-mediated induction of autophagy via an Apg1 protein kinase complex
-
doi:10.1083/jcb.150.6.1507
-
Kamada Y, Funakoshi T, Shintani T, Nagano K, Ohsumi M, Ohsumi Y. Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J Cell Biol (2000) 150:1507-13. doi:10.1083/jcb.150.6.1507
-
(2000)
J Cell Biol
, vol.150
, pp. 1507-1513
-
-
Kamada, Y.1
Funakoshi, T.2
Shintani, T.3
Nagano, K.4
Ohsumi, M.5
Ohsumi, Y.6
-
42
-
-
0035296203
-
Role of nitric oxide in carcinogenesis and tumour progression
-
doi:10.1016/S1470-2045(00)00256-4
-
Lala PK, Chakraborty C. Role of nitric oxide in carcinogenesis and tumour progression. Lancet Oncol (2001) 2:149-56. doi:10.1016/S1470-2045(00)00256-4
-
(2001)
Lancet Oncol
, vol.2
, pp. 149-156
-
-
Lala, P.K.1
Chakraborty, C.2
-
43
-
-
84878249924
-
Role of AMPK in UVB-induced DNA damage repair and growth control
-
doi:10.1038/onc.2012.279
-
Wu CL, Qiang L, Han W, Ming M, Viollet B, He YY. Role of AMPK in UVB-induced DNA damage repair and growth control. Oncogene (2013) 32:2682-9. doi:10.1038/onc.2012.279
-
(2013)
Oncogene
, vol.32
, pp. 2682-2689
-
-
Wu, C.L.1
Qiang, L.2
Han, W.3
Ming, M.4
Viollet, B.5
He, Y.Y.6
-
44
-
-
84861487778
-
Metformin and the mTOR inhibitor everolimus (RAD001) sensitize breast cancer cells to the cytotoxic effect of chemotherapeutic drugs in vitro
-
Liu H, Scholz C, Zang C, Schefe JH, Habbel P, Regierer AC, et al. Metformin and the mTOR inhibitor everolimus (RAD001) sensitize breast cancer cells to the cytotoxic effect of chemotherapeutic drugs in vitro. Anticancer Res (2012) 32:1627-37.
-
(2012)
Anticancer Res
, vol.32
, pp. 1627-1637
-
-
Liu, H.1
Scholz, C.2
Zang, C.3
Schefe, J.H.4
Habbel, P.5
Regierer, A.C.6
-
45
-
-
80655125020
-
Targeting energy metabolic and oncogenic signaling pathways in triple-negative breast cancer by a novel adenosine monophosphate-activated protein kinase (AMPK) activator
-
doi:10.1074/jbc.M111.264598
-
Lee KH, Hsu EC, Guh JH, Yang HC, Wang D, Kulp SK, et al. Targeting energy metabolic and oncogenic signaling pathways in triple-negative breast cancer by a novel adenosine monophosphate-activated protein kinase (AMPK) activator. J Biol Chem (2011) 286:39247-58. doi:10.1074/jbc.M111.264598
-
(2011)
J Biol Chem
, vol.286
, pp. 39247-39258
-
-
Lee, K.H.1
Hsu, E.C.2
Guh, J.H.3
Yang, H.C.4
Wang, D.5
Kulp, S.K.6
-
46
-
-
84858287883
-
Phenformin as prophylaxis and therapy in breast cancer xenografts
-
doi:10.1038/bjc.2012.56
-
Appleyard MV, Murray KE, Coates PJ, Wullschleger S, Bray SE, Kernohan NM, et al. Phenformin as prophylaxis and therapy in breast cancer xenografts. Br J Cancer (2012) 106:1117-22. doi:10.1038/bjc.2012.56
-
(2012)
Br J Cancer
, vol.106
, pp. 1117-1122
-
-
Appleyard, M.V.1
Murray, K.E.2
Coates, P.J.3
Wullschleger, S.4
Bray, S.E.5
Kernohan, N.M.6
-
47
-
-
84855242079
-
Effects of activation of AMPK on human breast cancer cell lines with different genetic backgrounds
-
El-Masry OS, Brown BL, Dobson PR. Effects of activation of AMPK on human breast cancer cell lines with different genetic backgrounds. Oncol Lett (2012) 3:224-8.
-
(2012)
Oncol Lett
, vol.3
, pp. 224-228
-
-
El-Masry, O.S.1
Brown, B.L.2
Dobson, P.R.3
-
48
-
-
78650494605
-
Proteomic profiling identifies pathways dysregulated in non-small cell lung cancer and an inverse association of AMPK and adhesion pathways with recurrence
-
doi:10.1097/JTO.0b013e3181f2a266
-
Nanjundan M, Byers LA, Carey MS, Siwak DR, Raso MG, Diao L, et al. Proteomic profiling identifies pathways dysregulated in non-small cell lung cancer and an inverse association of AMPK and adhesion pathways with recurrence. J Thorac Oncol (2010) 5:1894-904. doi:10.1097/JTO.0b013e3181f2a266
-
(2010)
J Thorac Oncol
, vol.5
, pp. 1894-1904
-
-
Nanjundan, M.1
Byers, L.A.2
Carey, M.S.3
Siwak, D.R.4
Raso, M.G.5
Diao, L.6
-
49
-
-
84855180734
-
The impact of phosphorylated AMP-activated protein kinase expression on lung cancer survival
-
doi:10.1093/annonc/mdr036
-
William WN, Kim JS, Liu DD, Solis L, Behrens C, Lee JJ, et al. The impact of phosphorylated AMP-activated protein kinase expression on lung cancer survival. Ann Oncol (2012) 23:78-85. doi:10.1093/annonc/mdr036
-
(2012)
Ann Oncol
, vol.23
, pp. 78-85
-
-
William, W.N.1
Kim, J.S.2
Liu, D.D.3
Solis, L.4
Behrens, C.5
Lee, J.J.6
-
50
-
-
84873560331
-
Negative regulation of mTOR activity by LKB1-AMPK signaling in non-small cell lung cancer cells
-
doi:10.1038/aps.2012.143
-
Dong LX, Sun LL, Zhang X, Pan L, Lian LJ, Chen Z, et al. Negative regulation of mTOR activity by LKB1-AMPK signaling in non-small cell lung cancer cells. Acta Pharmacol Sin (2013) 34:314-8. doi:10.1038/aps.2012.143
-
(2013)
Acta Pharmacol Sin
, vol.34
, pp. 314-318
-
-
Dong, L.X.1
Sun, L.L.2
Zhang, X.3
Pan, L.4
Lian, L.J.5
Chen, Z.6
-
51
-
-
84857467120
-
Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153
-
doi:10.4149/neo_2011_06_482
-
Wu N, Gu C, Gu H, Hu H, Han Y, Li Q. Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153. Neoplasma (2011) 58:482-90. doi:10.4149/neo_2011_06_482
-
(2011)
Neoplasma
, vol.58
, pp. 482-490
-
-
Wu, N.1
Gu, C.2
Gu, H.3
Hu, H.4
Han, Y.5
Li, Q.6
-
52
-
-
77956415337
-
Metformin prevents tobacco carcinogen-induced lung tumorigenesis
-
doi:10.1158/1940-6207.CAPR-10-0055
-
Memmott RM, Mercado JR, Maier CR, Kawabata S, Fox SD, Dennis PA. Metformin prevents tobacco carcinogen-induced lung tumorigenesis. Cancer Prev Res (Phila) (2010) 3:1066-76. doi:10.1158/1940-6207.CAPR-10-0055
-
(2010)
Cancer Prev Res (Phila)
, vol.3
, pp. 1066-1076
-
-
Memmott, R.M.1
Mercado, J.R.2
Maier, C.R.3
Kawabata, S.4
Fox, S.D.5
Dennis, P.A.6
-
53
-
-
79955755022
-
AMPK and Akt determine apoptotic cell death following perturbations of one-carbon metabolism by regulating ER stress in acute lymphoblastic leukemia
-
doi:10.1158/1535-7163.MCT-10-0777
-
Kuznetsov JN, Leclerc GJ, Leclerc GM, Barredo JC. AMPK and Akt determine apoptotic cell death following perturbations of one-carbon metabolism by regulating ER stress in acute lymphoblastic leukemia. Mol Cancer Ther (2011) 10:437-47. doi:10.1158/1535-7163.MCT-10-0777
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 437-447
-
-
Kuznetsov, J.N.1
Leclerc, G.J.2
Leclerc, G.M.3
Barredo, J.C.4
-
54
-
-
77956875005
-
AMPK-induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia
-
doi:10.1186/1750-2187-5-15
-
Leclerc GM, Leclerc GJ, Fu G, Barredo JC. AMPK-induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia. J Mol Signal (2010) 5:15. doi:10.1186/1750-2187-5-15
-
(2010)
J Mol Signal
, vol.5
, pp. 15
-
-
Leclerc, G.M.1
Leclerc, G.J.2
Fu, G.3
Barredo, J.C.4
-
55
-
-
34547981921
-
Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL) cells: implication for targeted therapy
-
doi:10.1186/1476-4598-6-46
-
Sengupta TK, Leclerc GM, Hsieh-Kinser TT, Leclerc GJ, Singh I, Barredo JC. Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL) cells: implication for targeted therapy. Mol Cancer (2007) 6:46. doi:10.1186/1476-4598-6-46
-
(2007)
Mol Cancer
, vol.6
, pp. 46
-
-
Sengupta, T.K.1
Leclerc, G.M.2
Hsieh-Kinser, T.T.3
Leclerc, G.J.4
Singh, I.5
Barredo, J.C.6
-
56
-
-
0012889321
-
Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes
-
doi:10.1182/blood-2002-07-2339
-
Campas C, Lopez JM, Santidrian AF, Barragan M, Bellosillo B, Colomer D, et al. Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes. Blood (2003) 101:3674-80. doi:10.1182/blood-2002-07-2339
-
(2003)
Blood
, vol.101
, pp. 3674-3680
-
-
Campas, C.1
Lopez, J.M.2
Santidrian, A.F.3
Barragan, M.4
Bellosillo, B.5
Colomer, D.6
-
57
-
-
64849110053
-
Stabilization and activation of p53 downregulates mTOR signaling through AMPK in mantle cell lymphoma
-
doi:10.1038/leu.2008.348
-
Drakos E, Atsaves V, Li J, Leventaki V, Andreeff M, Medeiros LJ, et al. Stabilization and activation of p53 downregulates mTOR signaling through AMPK in mantle cell lymphoma. Leukemia (2009) 23:784-90. doi:10.1038/leu.2008.348
-
(2009)
Leukemia
, vol.23
, pp. 784-790
-
-
Drakos, E.1
Atsaves, V.2
Li, J.3
Leventaki, V.4
Andreeff, M.5
Medeiros, L.J.6
-
58
-
-
83455225509
-
Antileukemic effects of AMPK activators on BCR-ABL-expressing cells
-
doi:10.1182/blood-2011-01-332783
-
Vakana E, Altman JK, Glaser H, Donato NJ, Platanias LC. Antileukemic effects of AMPK activators on BCR-ABL-expressing cells. Blood (2011) 118:6399-402. doi:10.1182/blood-2011-01-332783
-
(2011)
Blood
, vol.118
, pp. 6399-6402
-
-
Vakana, E.1
Altman, J.K.2
Glaser, H.3
Donato, N.J.4
Platanias, L.C.5
-
59
-
-
78549283186
-
The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation
-
doi:10.1182/blood-2010-02-269837
-
Green AS, Chapuis N, Maciel TT, Willems L, Lambert M, Arnoult C, et al. The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation. Blood (2010) 116:4262-73. doi:10.1182/blood-2010-02-269837
-
(2010)
Blood
, vol.116
, pp. 4262-4273
-
-
Green, A.S.1
Chapuis, N.2
Maciel, T.T.3
Willems, L.4
Lambert, M.5
Arnoult, C.6
-
60
-
-
84866256417
-
AMPK activators inhibit the proliferation of human melanomas bearing the activated MAPK pathway
-
doi:10.1097/CMR.0b013e3283544929
-
Petti C, Vegetti C, Molla A, Bersani I, Cleris L, Mustard KJ, et al. AMPK activators inhibit the proliferation of human melanomas bearing the activated MAPK pathway. Melanoma Res (2012) 22:341-50. doi:10.1097/CMR.0b013e3283544929
-
(2012)
Melanoma Res
, vol.22
, pp. 341-350
-
-
Petti, C.1
Vegetti, C.2
Molla, A.3
Bersani, I.4
Cleris, L.5
Mustard, K.J.6
-
61
-
-
84864059240
-
Metformin accelerates the growth of BRAF V600E-driven melanoma by upregulating VEGF-A
-
doi:10.1158/2159-8290.CD-11-0280
-
Martin MJ, Hayward R, Viros A, Marais R. Metformin accelerates the growth of BRAF V600E-driven melanoma by upregulating VEGF-A. Cancer Discov (2012) 2:344-55. doi:10.1158/2159-8290.CD-11-0280
-
(2012)
Cancer Discov
, vol.2
, pp. 344-355
-
-
Martin, M.J.1
Hayward, R.2
Viros, A.3
Marais, R.4
-
62
-
-
79952641534
-
Liver kinase B1 (LKB1) in the pathogenesis of UVB-induced murine basal cell carcinoma
-
doi:10.1016/j.abb.2011.01.006
-
Byekova YA, Herrmann JL, Xu J, Elmets CA, Athar M. Liver kinase B1 (LKB1) in the pathogenesis of UVB-induced murine basal cell carcinoma. Arch Biochem Biophys (2011) 508:204-11. doi:10.1016/j.abb.2011.01.006
-
(2011)
Arch Biochem Biophys
, vol.508
, pp. 204-211
-
-
Byekova, Y.A.1
Herrmann, J.L.2
Xu, J.3
Elmets, C.A.4
Athar, M.5
-
63
-
-
56749159779
-
UVB irradiation regulates Cox-2 mRNA stability through AMPK and HuR in human keratinocytes
-
doi:10.1002/mc.20450
-
Zhang J, Bowden GT. UVB irradiation regulates Cox-2 mRNA stability through AMPK and HuR in human keratinocytes. Mol Carcinog (2008) 47:974-83. doi:10.1002/mc.20450
-
(2008)
Mol Carcinog
, vol.47
, pp. 974-983
-
-
Zhang, J.1
Bowden, G.T.2
-
64
-
-
59149091041
-
Curcumin disrupts the Mammalian target of rapamycin-raptor complex
-
doi:10.1158/0008-5472.CAN-08-2367
-
Beevers CS, Chen L, Liu L, Luo Y, Webster NJ, Huang S. Curcumin disrupts the Mammalian target of rapamycin-raptor complex. Cancer Res (2009) 69:1000-8. doi:10.1158/0008-5472.CAN-08-2367
-
(2009)
Cancer Res
, vol.69
, pp. 1000-1008
-
-
Beevers, C.S.1
Chen, L.2
Liu, L.3
Luo, Y.4
Webster, N.J.5
Huang, S.6
-
65
-
-
59849113536
-
Curcumin exerts antidifferentiation effect through AMPKalpha-PPAR-gamma in 3T3-L1 adipocytes and antiproliferatory effect through AMPKalpha-COX-2 in cancer cells
-
doi:10.1021/jf802737z
-
Lee YK, Lee WS, Hwang JT, Kwon DY, Surh YJ, Park OJ. Curcumin exerts antidifferentiation effect through AMPKalpha-PPAR-gamma in 3T3-L1 adipocytes and antiproliferatory effect through AMPKalpha-COX-2 in cancer cells. J Agric Food Chem (2009) 57:305-10. doi:10.1021/jf802737z
-
(2009)
J Agric Food Chem
, vol.57
, pp. 305-310
-
-
Lee, Y.K.1
Lee, W.S.2
Hwang, J.T.3
Kwon, D.Y.4
Surh, Y.J.5
Park, O.J.6
-
66
-
-
69149108872
-
Regulatory effect of the AMPK-COX-2 signaling pathway in curcumin-induced apoptosis in HT-29 colon cancer cells
-
doi:10.1111/j.1749-6632.2009.04699.x
-
Lee YK, Park SY, Kim YM, Park OJ. Regulatory effect of the AMPK-COX-2 signaling pathway in curcumin-induced apoptosis in HT-29 colon cancer cells. Ann N Y Acad Sci (2009) 1171:489-94. doi:10.1111/j.1749-6632.2009.04699.x
-
(2009)
Ann N Y Acad Sci
, vol.1171
, pp. 489-494
-
-
Lee, Y.K.1
Park, S.Y.2
Kim, Y.M.3
Park, O.J.4
-
67
-
-
59249092573
-
AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells
-
Pan W, Yang H, Cao C, Song X, Wallin B, Kivlin R, et al. AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells. Oncol Rep (2008) 20:1553-9.
-
(2008)
Oncol Rep
, vol.20
, pp. 1553-1559
-
-
Pan, W.1
Yang, H.2
Cao, C.3
Song, X.4
Wallin, B.5
Kivlin, R.6
-
68
-
-
84862318573
-
Resveratrol and health: the starting point
-
doi:10.1002/cbic.201200193
-
Biasutto L, Mattarei A, Zoratti M. Resveratrol and health: the starting point. Chembiochem (2012) 13:1256-9. doi:10.1002/cbic.201200193
-
(2012)
Chembiochem
, vol.13
, pp. 1256-1259
-
-
Biasutto, L.1
Mattarei, A.2
Zoratti, M.3
-
69
-
-
0030942436
-
Alcohol, ischemic heart disease, and the French paradox
-
doi:10.1002/clc.4960200504
-
Constant J. Alcohol, ischemic heart disease, and the French paradox. Clin Cardiol (1997) 20:420-4. doi:10.1002/clc.4960200504
-
(1997)
Clin Cardiol
, vol.20
, pp. 420-424
-
-
Constant, J.1
-
70
-
-
0034645693
-
Biological effects of resveratrol
-
doi:10.1016/S0024-3205(99)00410-5
-
Fremont L. Biological effects of resveratrol. Life Sci (2000) 66:663-73. doi:10.1016/S0024-3205(99)00410-5
-
(2000)
Life Sci
, vol.66
, pp. 663-673
-
-
Fremont, L.1
-
71
-
-
84886461893
-
Resveratrol and clinical trials: the crossroad from in vitro studies to human evidence
-
[Epub ahead of print].
-
Tome-Carneiro J, Larrosa M, Gonzalez-Sarrias A, Tomas-Barberan FA, Garcia-Conesa MT, Espin JC. Resveratrol and clinical trials: the crossroad from in vitro studies to human evidence. Curr Pharm Des (2013). [Epub ahead of print].
-
(2013)
Curr Pharm Des
-
-
Tome-Carneiro, J.1
Larrosa, M.2
Gonzalez-Sarrias, A.3
Tomas-Barberan, F.A.4
Garcia-Conesa, M.T.5
Espin, J.C.6
-
72
-
-
0031561513
-
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
-
doi:10.1126/science.275.5297.218
-
Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science (1997) 275:218-20. doi:10.1126/science.275.5297.218
-
(1997)
Science
, vol.275
, pp. 218-220
-
-
Jang, M.1
Cai, L.2
Udeani, G.O.3
Slowing, K.V.4
Thomas, C.F.5
Beecher, C.W.6
-
73
-
-
33745962138
-
Therapeutic potential of resveratrol: the in vivo evidence
-
doi:10.1038/nrd2060
-
Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov (2006) 5:493-506. doi:10.1038/nrd2060
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 493-506
-
-
Baur, J.A.1
Sinclair, D.A.2
-
74
-
-
34247844379
-
Resveratrol induces apoptosis in chemoresistant cancer cells via modulation of AMPK signaling pathway
-
doi:10.1196/annals.1397.047
-
Hwang JT, Kwak DW, Lin SK, Kim HM, Kim YM, Park OJ. Resveratrol induces apoptosis in chemoresistant cancer cells via modulation of AMPK signaling pathway. Ann N Y Acad Sci (2007) 1095:441-8. doi:10.1196/annals.1397.047
-
(2007)
Ann N Y Acad Sci
, vol.1095
, pp. 441-448
-
-
Hwang, J.T.1
Kwak, D.W.2
Lin, S.K.3
Kim, H.M.4
Kim, Y.M.5
Park, O.J.6
-
75
-
-
84859947444
-
Resveratrol activates AMPK and suppresses LPS-induced NF-kappaB-dependent COX-2 activation in RAW 264.7 macrophage cells
-
doi:10.5115/acb.2011.44.3.194
-
Yi CO, Jeon BT, Shin HJ, Jeong EA, Chang KC, Lee JE, et al. Resveratrol activates AMPK and suppresses LPS-induced NF-kappaB-dependent COX-2 activation in RAW 264.7 macrophage cells. Anat Cell Biol (2011) 44:194-203. doi:10.5115/acb.2011.44.3.194
-
(2011)
Anat Cell Biol
, vol.44
, pp. 194-203
-
-
Yi, C.O.1
Jeon, B.T.2
Shin, H.J.3
Jeong, E.A.4
Chang, K.C.5
Lee, J.E.6
-
76
-
-
76249124608
-
Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation
-
doi:10.1158/0008-5472.CAN-09-3537
-
Puissant A, Robert G, Fenouille N, Luciano F, Cassuto JP, Raynaud S, et al. Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation. Cancer Res (2010) 70:1042-52. doi:10.1158/0008-5472.CAN-09-3537
-
(2010)
Cancer Res
, vol.70
, pp. 1042-1052
-
-
Puissant, A.1
Robert, G.2
Fenouille, N.3
Luciano, F.4
Cassuto, J.P.5
Raynaud, S.6
-
77
-
-
84867827531
-
Grape polyphenols inhibit Akt/mammalian target of rapamycin signaling and potentiate the effects of gefitinib in breast cancer
-
doi:10.1080/01635581.2012.716898
-
Castillo-Pichardo L, Dharmawardhane SF. Grape polyphenols inhibit Akt/mammalian target of rapamycin signaling and potentiate the effects of gefitinib in breast cancer. Nutr Cancer (2012) 64:1058-69. doi:10.1080/01635581.2012.716898
-
(2012)
Nutr Cancer
, vol.64
, pp. 1058-1069
-
-
Castillo-Pichardo, L.1
Dharmawardhane, S.F.2
-
78
-
-
81255144018
-
Resveratrol enhances prostate cancer cell response to ionizing radiation. Modulation of the AMPK Akt and mTOR pathways
-
doi:10.1186/1748-717X-6-144
-
Rashid A, Liu C, Sanli T, Tsiani E, Singh G, Bristow RG, et al. Resveratrol enhances prostate cancer cell response to ionizing radiation. Modulation of the AMPK Akt and mTOR pathways. Radiat Oncol (2011) 6:144. doi:10.1186/1748-717X-6-144
-
(2011)
Radiat Oncol
, vol.6
, pp. 144
-
-
Rashid, A.1
Liu, C.2
Sanli, T.3
Tsiani, E.4
Singh, G.5
Bristow, R.G.6
-
79
-
-
84863516150
-
Resveratrol enhances the antitumor effects of temozolomide in glioblastoma via ROS-dependent AMPK-TSC-mTOR signaling pathway
-
doi:10.1111/j.1755-5949.2012.00319.x
-
Yuan Y, Xue X, Guo RB, Sun XL, Hu G. Resveratrol enhances the antitumor effects of temozolomide in glioblastoma via ROS-dependent AMPK-TSC-mTOR signaling pathway. CNS Neurosci Ther (2012) 18:536-46. doi:10.1111/j.1755-5949.2012.00319.x
-
(2012)
CNS Neurosci Ther
, vol.18
, pp. 536-546
-
-
Yuan, Y.1
Xue, X.2
Guo, R.B.3
Sun, X.L.4
Hu, G.5
-
80
-
-
84872815877
-
3,4-Dimethoxystilbene, a resveratrol derivative with anti-angiogenic effect, induces both macroautophagy and apoptosis in endothelial cells
-
doi:10.1002/jcb.24411
-
Zhang L, Jing H, Cui L, Li H, Zhou B, Zhou G, et al. 3,4-Dimethoxystilbene, a resveratrol derivative with anti-angiogenic effect, induces both macroautophagy and apoptosis in endothelial cells. J Cell Biochem (2013) 114:697-707. doi:10.1002/jcb.24411
-
(2013)
J Cell Biochem
, vol.114
, pp. 697-707
-
-
Zhang, L.1
Jing, H.2
Cui, L.3
Li, H.4
Zhou, B.5
Zhou, G.6
-
81
-
-
23044455268
-
The antitumor activities of flavonoids
-
Kandaswami C, Lee LT, Lee PP, Hwang JJ, Ke FC, Huang YT, et al. The antitumor activities of flavonoids. In vivo (2005) 19:895-909.
-
(2005)
In vivo
, vol.19
, pp. 895-909
-
-
Kandaswami, C.1
Lee, L.T.2
Lee, P.P.3
Hwang, J.J.4
Ke, F.C.5
Huang, Y.T.6
-
82
-
-
77955214065
-
The antioxidant effects of genistein are associated with AMP-activated protein kinase activation and PTEN induction in prostate cancer cells
-
doi:10.1089/jmf.2009.1359
-
Park CE, Yun H, Lee EB, Min BI, Bae H, Choe W, et al. The antioxidant effects of genistein are associated with AMP-activated protein kinase activation and PTEN induction in prostate cancer cells. J Med Food (2010) 13:815-20. doi:10.1089/jmf.2009.1359
-
(2010)
J Med Food
, vol.13
, pp. 815-820
-
-
Park, C.E.1
Yun, H.2
Lee, E.B.3
Min, B.I.4
Bae, H.5
Choe, W.6
-
83
-
-
47249154397
-
Genistein selectively potentiates arsenic trioxide-induced apoptosis in human leukemia cells via reactive oxygen species generation and activation of reactive oxygen species-inducible protein kinases (p38-MAPK, AMPK)
-
doi:10.1002/ijc.23639
-
Sanchez Y, Amran D, Fernandez C, de Blas E, Aller P. Genistein selectively potentiates arsenic trioxide-induced apoptosis in human leukemia cells via reactive oxygen species generation and activation of reactive oxygen species-inducible protein kinases (p38-MAPK, AMPK). Int J Cancer (2008) 123:1205-14. doi:10.1002/ijc.23639
-
(2008)
Int J Cancer
, vol.123
, pp. 1205-1214
-
-
Sanchez, Y.1
Amran, D.2
Fernandez, C.3
de Blas, E.4
Aller, P.5
-
84
-
-
78649440083
-
Regulation of mutual inhibitory activities between AMPK and Akt with quercetin in MCF-7 breast cancer cells
-
Lee YK, Park OJ. Regulation of mutual inhibitory activities between AMPK and Akt with quercetin in MCF-7 breast cancer cells. Oncol Rep (2010) 24:1493-7.
-
(2010)
Oncol Rep
, vol.24
, pp. 1493-1497
-
-
Lee, Y.K.1
Park, O.J.2
-
85
-
-
84862819739
-
Activation of reactive oxygen species/AMP activated protein kinase signaling mediates fisetin-induced apoptosis in multiple myeloma U266 cells
-
doi:10.1016/j.canlet.2012.01.008
-
Jang KY, Jeong SJ, Kim SH, Jung JH, Kim JH, Koh W, et al. Activation of reactive oxygen species/AMP activated protein kinase signaling mediates fisetin-induced apoptosis in multiple myeloma U266 cells. Cancer Lett (2012) 319:197-202. doi:10.1016/j.canlet.2012.01.008
-
(2012)
Cancer Lett
, vol.319
, pp. 197-202
-
-
Jang, K.Y.1
Jeong, S.J.2
Kim, S.H.3
Jung, J.H.4
Kim, J.H.5
Koh, W.6
-
86
-
-
84856329735
-
Dual inhibition of phosphatidylinositol 3-kinase/Akt and mammalian target of rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid fisetin
-
doi:10.1002/ijc.26178
-
Khan N, Afaq F, Khusro FH, Mustafa Adhami V, Suh Y, Mukhtar H. Dual inhibition of phosphatidylinositol 3-kinase/Akt and mammalian target of rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid fisetin. Int J Cancer (2012) 130:1695-705. doi:10.1002/ijc.26178
-
(2012)
Int J Cancer
, vol.130
, pp. 1695-1705
-
-
Khan, N.1
Afaq, F.2
Khusro, F.H.3
Mustafa Adhami, V.4
Suh, Y.5
Mukhtar, H.6
-
87
-
-
77955355798
-
Fisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cells
-
doi:10.1093/carcin/bgq115
-
Suh Y, Afaq F, Khan N, Johnson JJ, Khusro FH, Mukhtar H. Fisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cells. Carcinogenesis (2010) 31:1424-33. doi:10.1093/carcin/bgq115
-
(2010)
Carcinogenesis
, vol.31
, pp. 1424-1433
-
-
Suh, Y.1
Afaq, F.2
Khan, N.3
Johnson, J.J.4
Khusro, F.H.5
Mukhtar, H.6
-
88
-
-
77955699748
-
Apoptotic effect of quercetin on HT-29 colon cancer cells via the AMPK signaling pathway
-
doi:10.1021/jf101510z
-
Kim HJ, Kim SK, Kim BS, Lee SH, Park YS, Park BK, et al. Apoptotic effect of quercetin on HT-29 colon cancer cells via the AMPK signaling pathway. J Agric Food Chem (2010) 58:8643-50. doi:10.1021/jf101510z
-
(2010)
J Agric Food Chem
, vol.58
, pp. 8643-8650
-
-
Kim, H.J.1
Kim, S.K.2
Kim, B.S.3
Lee, S.H.4
Park, Y.S.5
Park, B.K.6
-
89
-
-
77950792403
-
Quercetin suppresses HeLa cell viability via AMPK-induced HSP70 and EGFR down-regulation
-
doi:10.1002/jcp.22049
-
Jung JH, Lee JO, Kim JH, Lee SK, You GY, Park SH, et al. Quercetin suppresses HeLa cell viability via AMPK-induced HSP70 and EGFR down-regulation. J Cell Physiol (2010) 223:408-14. doi:10.1002/jcp.22049
-
(2010)
J Cell Physiol
, vol.223
, pp. 408-414
-
-
Jung, J.H.1
Lee, J.O.2
Kim, J.H.3
Lee, S.K.4
You, G.Y.5
Park, S.H.6
-
90
-
-
84255215187
-
Apigenin, a chemopreventive bioflavonoid, induces AMP-activated protein kinase activation in human keratinocytes
-
doi:10.1002/mc.20793
-
Tong X, Smith KA, Pelling JC. Apigenin, a chemopreventive bioflavonoid, induces AMP-activated protein kinase activation in human keratinocytes. Mol Carcinog (2012) 51:268-79. doi:10.1002/mc.20793
-
(2012)
Mol Carcinog
, vol.51
, pp. 268-279
-
-
Tong, X.1
Smith, K.A.2
Pelling, J.C.3
-
91
-
-
79955838953
-
Anti-tumor effect of luteolin is accompanied by AMP-activated protein kinase and nuclear factor-kappaB modulation in HepG2 hepatocarcinoma cells
-
doi:10.3892/ijmm.2011.667
-
Hwang JT, Park OJ, Lee YK, Sung MJ, Hur HJ, Kim MS, et al. Anti-tumor effect of luteolin is accompanied by AMP-activated protein kinase and nuclear factor-kappaB modulation in HepG2 hepatocarcinoma cells. Int J Mol Med (2011) 28:25-31. doi:10.3892/ijmm.2011.667
-
(2011)
Int J Mol Med
, vol.28
, pp. 25-31
-
-
Hwang, J.T.1
Park, O.J.2
Lee, Y.K.3
Sung, M.J.4
Hur, H.J.5
Kim, M.S.6
-
92
-
-
22244457999
-
Effect of deguelin on UVB-induced skin carcinogenesis
-
Gills JJ, Kosmeder J 2nd, Moon RC, Lantvit DD, Pezzuto JM. Effect of deguelin on UVB-induced skin carcinogenesis. J Chemother (2005) 17:297-301.
-
(2005)
J Chemother
, vol.17
, pp. 297-301
-
-
Gills, J.J.1
Kosmeder I.I, J.2
Moon, R.C.3
Lantvit, D.D.4
Pezzuto, J.M.5
-
93
-
-
84873313731
-
Celastrol suppresses breast cancer MCF-7 cell viability via the AMP-activated protein kinase (AMPK)-induced p53-polo like kinase 2 (PLK-2) pathway
-
doi:10.1016/j.cellsig.2012.12.005
-
Kim JH, Lee JO, Lee SK, Kim N, You GY, Moon JW, et al. Celastrol suppresses breast cancer MCF-7 cell viability via the AMP-activated protein kinase (AMPK)-induced p53-polo like kinase 2 (PLK-2) pathway. Cell Signal (2013) 25:805-13. doi:10.1016/j.cellsig.2012.12.005
-
(2013)
Cell Signal
, vol.25
, pp. 805-813
-
-
Kim, J.H.1
Lee, J.O.2
Lee, S.K.3
Kim, N.4
You, G.Y.5
Moon, J.W.6
-
94
-
-
84863331815
-
AMP-activated protein kinase (AMPK) activation is involved in chrysin-induced growth inhibition and apoptosis in cultured A549 lung cancer cells
-
doi:10.1016/j.bbrc.2012.05.123
-
Shao JJ, Zhang AP, Qin W, Zheng L, Zhu YF, Chen X. AMP-activated protein kinase (AMPK) activation is involved in chrysin-induced growth inhibition and apoptosis in cultured A549 lung cancer cells. Biochem Biophys Res Commun (2012) 423:448-53. doi:10.1016/j.bbrc.2012.05.123
-
(2012)
Biochem Biophys Res Commun
, vol.423
, pp. 448-453
-
-
Shao, J.J.1
Zhang, A.P.2
Qin, W.3
Zheng, L.4
Zhu, Y.F.5
Chen, X.6
-
95
-
-
33845789994
-
Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway
-
doi:10.1016/j.canlet.2006.03.030
-
Hwang JT, Ha J, Park IJ, Lee SK, Baik HW, Kim YM, et al. Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway. Cancer Lett (2007) 247:115-21. doi:10.1016/j.canlet.2006.03.030
-
(2007)
Cancer Lett
, vol.247
, pp. 115-121
-
-
Hwang, J.T.1
Ha, J.2
Park, I.J.3
Lee, S.K.4
Baik, H.W.5
Kim, Y.M.6
-
96
-
-
84862783302
-
Novel epigallocatechin gallate (EGCG) analogs activate AMP-activated protein kinase pathway and target cancer stem cells
-
doi:10.1016/j.bmc.2012.03.002
-
Chen D, Pamu S, Cui Q, Chan TH, Dou QP. Novel epigallocatechin gallate (EGCG) analogs activate AMP-activated protein kinase pathway and target cancer stem cells. Bioorg Med Chem (2012) 20:3031-7. doi:10.1016/j.bmc.2012.03.002
-
(2012)
Bioorg Med Chem
, vol.20
, pp. 3031-3037
-
-
Chen, D.1
Pamu, S.2
Cui, Q.3
Chan, T.H.4
Dou, Q.P.5
-
97
-
-
79955791260
-
Preventive effects of (-)-epigallocatechin gallate on diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db Mice
-
doi:10.1158/1940-6207.CAPR-10-0331
-
Shimizu M, Sakai H, Shirakami Y, Yasuda Y, Kubota M, Terakura D, et al. Preventive effects of (-)-epigallocatechin gallate on diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db Mice. Cancer Prev Res (Phila) (2011) 4:396-403. doi:10.1158/1940-6207.CAPR-10-0331
-
(2011)
Cancer Prev Res (Phila)
, vol.4
, pp. 396-403
-
-
Shimizu, M.1
Sakai, H.2
Shirakami, Y.3
Yasuda, Y.4
Kubota, M.5
Terakura, D.6
-
98
-
-
84861303760
-
Green tea polyphenol epigallocatechin-3-gallate enhances 5-fluorouracil-induced cell growth inhibition of hepatocellular carcinoma cells
-
doi:10.1111/j.1872-034X.2011.00947.x
-
Yang XW, Wang XL, Cao LQ, Jiang XF, Peng HP, Lin SM, et al. Green tea polyphenol epigallocatechin-3-gallate enhances 5-fluorouracil-induced cell growth inhibition of hepatocellular carcinoma cells. Hepatol Res (2012) 42:494-501. doi:10.1111/j.1872-034X.2011.00947.x
-
(2012)
Hepatol Res
, vol.42
, pp. 494-501
-
-
Yang, X.W.1
Wang, X.L.2
Cao, L.Q.3
Jiang, X.F.4
Peng, H.P.5
Lin, S.M.6
-
99
-
-
84455208086
-
Berberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction of ERK activity and COX-2 protein expression
-
doi:10.1016/j.bcp.2011.11.008
-
Kim HS, Kim MJ, Kim EJ, Yang Y, Lee MS, Lim JS. Berberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction of ERK activity and COX-2 protein expression. Biochem Pharmacol (2012) 83:385-94. doi:10.1016/j.bcp.2011.11.008
-
(2012)
Biochem Pharmacol
, vol.83
, pp. 385-394
-
-
Kim, H.S.1
Kim, M.J.2
Kim, E.J.3
Yang, Y.4
Lee, M.S.5
Lim, J.S.6
-
100
-
-
84867193563
-
Berberine inhibits human colon cancer cell migration via AMP-activated protein kinase-mediated downregulation of integrin beta1 signaling
-
doi:10.1016/j.bbrc.2012.08.091
-
Park JJ, Seo SM, Kim EJ, Lee YJ, Ko YG, Ha J, et al. Berberine inhibits human colon cancer cell migration via AMP-activated protein kinase-mediated downregulation of integrin beta1 signaling. Biochem Biophys Res Commun (2012) 426:461-7. doi:10.1016/j.bbrc.2012.08.091
-
(2012)
Biochem Biophys Res Commun
, vol.426
, pp. 461-467
-
-
Park, J.J.1
Seo, S.M.2
Kim, E.J.3
Lee, Y.J.4
Ko, Y.G.5
Ha, J.6
-
101
-
-
77952088621
-
24-Hydroxyursolic acid from the leaves of the Diospyros kaki (Persimmon) induces apoptosis by activation of AMP-activated protein kinase
-
doi:10.1055/s-0029-1240678
-
Khanal P, Oh WK, Thuong PT, Cho SD, Choi HS 24-Hydroxyursolic acid from the leaves of the Diospyros kaki (Persimmon) induces apoptosis by activation of AMP-activated protein kinase. Planta Med (2010) 76:689-93. doi:10.1055/s-0029-1240678
-
(2010)
Planta Med
, vol.76
, pp. 689-693
-
-
Khanal, P.1
Oh, W.K.2
Thuong, P.T.3
Cho, S.D.4
Choi, H.S.5
-
102
-
-
79953713983
-
p-HPEA-EDA, a phenolic compound of virgin olive oil, activates AMP-activated protein kinase to inhibit carcinogenesis
-
doi:10.1093/carcin/bgr001
-
Khanal P, Oh WK, Yun HJ, Namgoong GM, Ahn SG, Kwon SM, et al. p-HPEA-EDA, a phenolic compound of virgin olive oil, activates AMP-activated protein kinase to inhibit carcinogenesis. Carcinogenesis (2011) 32:545-53. doi:10.1093/carcin/bgr001
-
(2011)
Carcinogenesis
, vol.32
, pp. 545-553
-
-
Khanal, P.1
Oh, W.K.2
Yun, H.J.3
Namgoong, G.M.4
Ahn, S.G.5
Kwon, S.M.6
-
103
-
-
34247898927
-
Involvement of AMPK signaling cascade in capsaicin-induced apoptosis of HT-29 colon cancer cells
-
doi:10.1196/annals.1397.053
-
Kim YM, Hwang JT, Kwak DW, Lee YK, Park OJ. Involvement of AMPK signaling cascade in capsaicin-induced apoptosis of HT-29 colon cancer cells. Ann N Y Acad Sci (2007) 1095:496-503. doi:10.1196/annals.1397.053
-
(2007)
Ann N Y Acad Sci
, vol.1095
, pp. 496-503
-
-
Kim, Y.M.1
Hwang, J.T.2
Kwak, D.W.3
Lee, Y.K.4
Park, O.J.5
-
104
-
-
84863470109
-
Honokiol suppresses the development of post-ischemic glucose intolerance and neuronal damage in mice
-
doi:10.1007/s11418-011-0623-x
-
Harada S, Kishimoto M, Kobayashi M, Nakamoto K, Fujita-Hamabe W, Chen HH, et al. Honokiol suppresses the development of post-ischemic glucose intolerance and neuronal damage in mice. J Nat Med (2012) 66:591-9. doi:10.1007/s11418-011-0623-x
-
(2012)
J Nat Med
, vol.66
, pp. 591-599
-
-
Harada, S.1
Kishimoto, M.2
Kobayashi, M.3
Nakamoto, K.4
Fujita-Hamabe, W.5
Chen, H.H.6
-
105
-
-
76449110705
-
Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation
-
doi:10.1021/jf9035782
-
Lin JN, Lin VC, Rau KM, Shieh PC, Kuo DH, Shieh JC, et al. Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation. J Agric Food Chem (2010) 58:1584-92. doi:10.1021/jf9035782
-
(2010)
J Agric Food Chem
, vol.58
, pp. 1584-1592
-
-
Lin, J.N.1
Lin, V.C.2
Rau, K.M.3
Shieh, P.C.4
Kuo, D.H.5
Shieh, J.C.6
-
106
-
-
78649392683
-
Anthocyanins are novel AMPKalpha1 stimulators that suppress tumor growth by inhibiting mTOR phosphorylation
-
Lee YK, Lee WS, Kim GS, Park OJ. Anthocyanins are novel AMPKalpha1 stimulators that suppress tumor growth by inhibiting mTOR phosphorylation. Oncol Rep (2010) 24:1471-7.
-
(2010)
Oncol Rep
, vol.24
, pp. 1471-1477
-
-
Lee, Y.K.1
Lee, W.S.2
Kim, G.S.3
Park, O.J.4
-
107
-
-
80053979666
-
Novel synthetic baicalein derivatives caused apoptosis and activated AMP-activated protein kinase in human tumor cells
-
doi:10.1039/c1ob06094e
-
Ding D, Zhang B, Meng T, Ma Y, Wang X, Peng H, et al. Novel synthetic baicalein derivatives caused apoptosis and activated AMP-activated protein kinase in human tumor cells. Org Biomol Chem (2011) 9:7287-91. doi:10.1039/c1ob06094e
-
(2011)
Org Biomol Chem
, vol.9
, pp. 7287-7291
-
-
Ding, D.1
Zhang, B.2
Meng, T.3
Ma, Y.4
Wang, X.5
Peng, H.6
-
108
-
-
77956245936
-
Hispidulin potently inhibits human glioblastoma multiforme cells through activation of AMP-activated protein kinase (AMPK)
-
doi:10.1021/jf1019533
-
Lin YC, Hung CM, Tsai JC, Lee JC, Chen YL, Wei CW, et al. Hispidulin potently inhibits human glioblastoma multiforme cells through activation of AMP-activated protein kinase (AMPK). J Agric Food Chem (2010) 58:9511-7. doi:10.1021/jf1019533
-
(2010)
J Agric Food Chem
, vol.58
, pp. 9511-9517
-
-
Lin, Y.C.1
Hung, C.M.2
Tsai, J.C.3
Lee, J.C.4
Chen, Y.L.5
Wei, C.W.6
-
109
-
-
82755195287
-
The combination of tephrosin with 2-deoxy-D-glucose enhances the cytotoxicity via accelerating ATP depletion and blunting autophagy in human cancer cells
-
doi:10.4161/cbt.12.11.18364
-
Choi Y, Lee JH. The combination of tephrosin with 2-deoxy-D-glucose enhances the cytotoxicity via accelerating ATP depletion and blunting autophagy in human cancer cells. Cancer Biol Ther (2011) 12:989-96. doi:10.4161/cbt.12.11.18364
-
(2011)
Cancer Biol Ther
, vol.12
, pp. 989-996
-
-
Choi, Y.1
Lee, J.H.2
|