Negative regulation of mTOR activity by LKB1-AMPK signaling in non-small cell lung cancer cells

Acta Pharmacologica Sinica

Volumn 34, Issue 2, 2013, Pages 314-318

  Dong, Li Xia ^a   Sun, Lin Lin ^a   Zhang, Xia ^a   Pan, Li ^a   Lian, Lin Juan ^a   Chen, Zhe ^a   Zhong, Dian Sheng ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

2 deoxyglucose; LKB1 AMPK mTOR; non small cell lung cancer

Indexed keywords

ADENYLATE KINASE; DEOXYGLUCOSE; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE LKB1;

ARTICLE; CANCER GROWTH; CELL STRESS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; IN VITRO STUDY; LUNG NON SMALL CELL CANCER; NONSENSE MUTATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; WILD TYPE;

AMP-ACTIVATED PROTEIN KINASES; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL PROLIFERATION; ENERGY METABOLISM; ENZYME ACTIVATION; HUMANS; LUNG; LUNG NEOPLASMS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84873560331     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2012.143     Document Type: Article

References (22)

1. Hemminki A, Markie D, Tomlinson I, Avizienyte E, Roth S, Loukola A, et al. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature 1998; 391: 184-7.
2. Giardiello FM, Brensinger JD, Tersmette AC, Goodman SN, Petersen GM, Booker SV, et al. Very high risk of cancer in familial Peutz-Jeghers syndrome. Gastroenterology 2000; 119: 1447-53.
3. Lim W, Hearle N, Shah B, Murday V, Hodgson SV, Lucassenet A, et al. Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome. Br J Cancer 2003; 89: 308-13.
4. Sanchez-Cespedes M, Parrella P, Esteller M, Nomoto S, Trink B, Engles JM, et al. Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Cancer Res 2002; 62: 3659-62.
5. Matsumoto S, Iwakawa R, Takahash K, Kohno T, Nakanishi Y, Matsuno Y, et al. Prevalence and specificity of LKB1 genetic alteration in lung cancer. Oncogene 2007; 26: 1-8.
6. Zhong DS, Guo LZ, de Aguirre I, Liu XJ, Lamb N, Sun SY, et al. LKB1 mutation in large cell carcinoma of the lung. Lung Cancer 2006; 53: 285-94.
7. Marcus AI, Zhou W. LKB1 regulated pathways in lung cancer invasion and metastasis. J Thorac Oncol 2010; 5: 1883-6.
8. Zhang X, Sun L, Zhong D. Advances of LKB1-AMPK-mTOR signaling pathway in tumor. Zhongguo Fei Ai Za Zhi 2011; 14: 685-8.
9. Gao Y, Ge G, Ji H. LKB1 in lung cancerigenesis: a serine/threonine kinase as tumor suppressor. Protein Cell 2011; 2: 99-107.
10. Herrmann JL, Byekova Y, Elmets CA, Athar M. Liver kinase B1 (LKB1) in the pathogenesis of epithelial cancers. Cancer Lett 2011; 306: 1-9.
11. Brown J. Effects of 2-deoxyglucose on carbohydrate metabolism: review of the literature and studies in the rat. Metabolism 1962; 11: 1098-112.
12. Pelicano H, Martin DS, Xu RH, Huang P. Glycolysis inhibition for anticancer treatment. Oncogene 2006; 25: 4633-46.
13. Shaw RJ. Glucose metabolism and cancer. Curr Opin Cell Biol 2006; 18: 598-608.
14. Weindruch R, Keenan KP, Carney JM, Fernandes G, Feuers RJ, Floyd RA, et al. Caloric restriction mimetics: metabolic interventions. J Gerontol A Biol Sci Med Sci 2001; 56: 20-33.
15. Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Mäkelä TP, et al. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2003; 2: 28.
16. Woods A, Johnstone SR, Dickerson K, Leiper FC, Fryer LG, Neumann D, et al. LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol 2003; 13: 2004-8.
17. Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003; 115: 577-90.
18. Corradetti MN, Inoki K, Bardeesy N, DePinho RA, Guan KL. Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev 2004; 18: 1533-8.
19. Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, et al. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell 2004; 6: 91-9.
20. Sun LL, Zhong DS, Wu S, Bai H, Chen Z. Establishment and gene expression profiling of LKB1 stable knockdown lung cancer cell line. Chin Med J 2011; 124: 2028-32.
21. Swinnen JV, Beckers A, Brusselmans K, Organe S, Segers J, Timmermans L, et al. Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype. Cancer Res 2005; 65: 2441-8.
22. J Carretero, PP Medina, R Blanco, L Smit, M Tang, G Roncador, et al. Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-de?cient lung cancer. Oncogene 2007; 26: 1616-25.