AMP-activated protein kinase (AMPK) activation is involved in chrysin-induced growth inhibition and apoptosis in cultured A549 lung cancer cells

Biochemical and Biophysical Research Communications

Volumn 423, Issue 3, 2012, Pages 448-453

  Shao, Jun Jie ^a   Zhang, Ai Ping ^a   Qin, Wei ^a   Zheng, Lin ^a   Zhu, Yi Fan ^a   Chen, Xin ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

AMPK; Apoptosis; Chrysin; Doxorubicin; Lung cancer

Indexed keywords

ADENYLATE KINASE; CHRYSIN; DOXORUBICIN; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; SHORT HAIRPIN RNA;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CONTROLLED STUDY; DRUG POTENTIATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LUNG CANCER; MOLECULAR MECHANICS; PRIORITY JOURNAL;

AMP-ACTIVATED PROTEIN KINASES; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CHEMOTHERAPY, ADJUVANT; DOXORUBICIN; ENZYME ACTIVATION; FLAVONOIDS; HUMANS; LUNG NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; TOR SERINE-THREONINE KINASES;

EID: 84863331815     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.05.123     Document Type: Article

References (33)

1. Schiller J.H., Harrington D., Belani C.P., Langer C., Sandler A., Krook J., Zhu J., Johnson D.H. Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N. Engl. J. Med. 2002, 346:92-98.
2. Spira A., Ettinger D.S. Multidisciplinary management of lung cancer. N. Engl. J. Med. 2004, 350:379-392.
3. Williams C.A., Harborne J.B., Newman M., Greenham J., Eagles J. Chrysin and other leaf exudate flavonoids in the genus Pelargonium. Phytochemistry 1997, 46:1349-1353.
4. Rapta P., Misik V., Stasko A., Vrabel I. Redox intermediates of flavonoids and caffeic acid esters from propolis: an EPR spectroscopy and cyclic voltammetry study. Free. Radical Biol. Med. 1995, 18:901-908.
5. Khoo B.Y., Chua S.L., Balaram P. Apoptotic effects of chrysin in human cancer cell lines. Int. J. Mol. Sci. 2010, 11:2188-2199.
6. Phan T., Yu X.M., Kunnimalaiyaan M., Chen H. Antiproliferative effect of chrysin on anaplastic thyroid cancer. J. Surg. Res. 2011, 170:84-88.
7. Yang X.H., Zheng X., Cao J.G., Xiang H.L., Liu F., Lv Y. 8-Bromo-7-methoxychrysin-induced apoptosis of hepatocellular carcinoma cells involves ROS and JNK. World J. Gastroenterol. 2012, 16:3385-3393.
8. Woo K.J., Jeong Y.J., Park J.W., Kwon T.K. Chrysin-induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells. Biochem. Biophys. Res. Commun. 2004, 325:1215-1222.
9. Hayashi T., Hirshman M.F., Fujii N., Habinowski S.A., Witters L.A., Goodyear L.J. Metabolic stress and altered glucose transport: activation of AMP-activated protein kinase as a unifying coupling mechanism. Diabetes 2000, 49:527-531.
10. Terai K., Hiramoto Y., Masaki M., Sugiyama S., Kuroda T., Hori M., Kawase I., Hirota H. AMP-activated protein kinase protects cardiomyocytes against hypoxic injury through attenuation of endoplasmic reticulum stress. Mol. Cell. Biol. 2005, 25:9554-9575.
11. Mizushina Y., Iida A., Ohta K., Sugawara F., Sakaguchi K. Novel triterpenoids inhibit both DNA polymerase and DNA topoisomerase. Biochem. J. 2000, 350(Pt 3):757-763.
12. Kefas B.A., Cai Y., Ling Z., Heimberg H., Hue L., Pipeleers D., Van de Casteele M. AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase. J. Mol. Endocrinol. 2003, 30:151-161.
13. Meisse D., Van de Casteele M., Beauloye C., Hainault I., Kefas B.A., Rider M.H., Foufelle F., Hue L. Sustained activation of AMP-activated protein kinase induces c-Jun N-terminal kinase activation and apoptosis in liver cells. FEBS Lett. 2002, 526:38-42.
14. Kang M.R., Park S.K., Lee C.W., Cho I.J., Jo Y.N., Yang J.W., Kim J.A., Yun J., Lee K.H., Kwon H.J., Kim B.W., Lee K., Kang J.S., Kim H.M. Widdrol induces apoptosis via activation of AMP-activated protein kinase in colon cancer cells. Oncol. Rep. 2012, 27:1407-1412.
15. Okoshi R., Ozaki T., Yamamoto H., Ando K., Koida N., Ono S., Koda T., Kamijo T., Nakagawara A., Kizaki H. Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress. J. Biol. Chem. 2008, 283:3979-3987.
16. Imamura K., Ogura T., Kishimoto A., Kaminishi M., Esumi H. Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-d-ribofuranoside, in a human hepatocellular carcinoma cell line. Biochem. Biophys. Res. Commun. 2001, 287:562-567.
17. Gwinn D.M., Shackelford D.B., Egan D.F., Mihaylova M.M., Mery A., Vasquez D.S., Turk B.E., Shaw R.J. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol. Cell 2008, 30:214-226.
18. Chen M.B., Wu X.Y., Gu J.H., Guo Q.T., Shen W.X., Lu P.H. Activation of AMP-activated protein kinase contributes to doxorubicin-induced cell death and apoptosis in cultured myocardial H9c2 cells. Cell Biochem. Biophys. 2011, 60:311-322.
19. Zheng Q.Y., Jin F.S., Yao C., Zhang T., Zhang G.H., Ai X. Ursolic acid-induced AMP-activated protein kinase (AMPK) activation contributes to growth inhibition and apoptosis in human bladder cancer T24 cells. Biochem. Biophys. Res. Commun. 2012.
20. Ji C., Yang B., Yang Y.L., He S.H., Miao D.S., He L., Bi Z.G. Exogenous cell-permeable C6 ceramide sensitizes multiple cancer cell lines to Doxorubicin-induced apoptosis by promoting AMPK activation and mTORC1 inhibition. Oncogene 2010, 29:6557-6568.
21. 2-induced apoptosis in human skin keratinocytes. J. Biol. Chem. 2008, 283:28897-28908.
22. Vakana E., Altman J.K., Platanias L.C. Targeting AMPK in the treatment of malignancies. J. Cell. Biochem. 2012, 113:404-409.
23. Chen M.B., Shen W.X., Yang Y., Wu X.Y., Gu J.H., Lu P.H. Activation of AMP-activated protein kinase is involved in vincristine-induced cell apoptosis in B16 melanoma cell. J. Cell. Physiol. 2011, 226:1915-1925.
24. Chen M.B., Wu X.Y., Gu J.H., Guo Q.T., Shen W.X., Lu P.H. Activation of AMP-activated protein kinase contributes to doxorubicin-induced cell death and apoptosis in cultured myocardial H9c2 cells. Cell Biochem. Biophys. 2010, 60:311-322.
25. Rocha G.Z., Dias M.M., Ropelle E.R., Osorio-Costa F., Rossato F.A., Vercesi A.E., Saad M.J., Carvalheira J.B. Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth. Clin. Cancer Res. 2011, 17:3993-4005.
26. Sun H., Yu T., Li J. Co-administration of perifosine with paclitaxel synergistically induces apoptosis in ovarian cancer cells: more than just AKT inhibition. Cancer Lett. 2011, 310:118-128.
27. Zheng Q.Y., Jin F.S., Yao C., Zhang T., Zhang G.H., Ai X. Ursolic acid-induced AMP-activated protein kinase (AMPK) activation contributes to growth inhibition and apoptosis in human bladder cancer T24 cells. Biochem. Biophys. Res. Commun. 2012, 419:741-747.
28. Nagalingam A., Arbiser J.L., Bonner M.Y., Saxena N.K., Sharma D. Honokiol activates AMP-activated protein kinase in breast cancer cells via an LKB1-dependent pathway and inhibits breast carcinogenesis. Breast Cancer Res. 2012, 14:R35.
29. Hwang J.T., Ha J., Park I.J., Lee S.K., Baik H.W., Kim Y.M., Park O.J. Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway. Cancer Lett. 2007, 247:115-121.
30. Jang K.Y., Jeong S.J., Kim S.H., Jung J.H., Kim J.H., Koh W., Chen C.Y., Kim S.H. Activation of reactive oxygen species/AMP activated protein kinase signaling mediates fisetin-induced apoptosis in multiple myeloma U266 cells. Cancer Lett. 2012.
31. Kachadourian R., Day B.J. Flavonoid-induced glutathione depletion: potential implications for cancer treatment. Free Radical Biol. Med. 2006, 41:65-76.
32. Hodnick W.F., Ahmad S., Pardini R.S. Induction of oxidative stress by redox active flavonoids. Adv. Exp. Med. Biol. 1998, 439:131-150.
33. Chen L., Xu B., Liu L., Luo Y., Yin J., Zhou H., Chen W., Shen T., Han X., Huang S. Hydrogen peroxide inhibits mTOR signaling by activation of AMPKalpha leading to apoptosis of neuronal cells. Lab. Invest. 2010, 90:762-773.