Genistein selectively potentiates arsenic trioxide-induced apoptosis in human leukemia cells via reactive oxygen species generation and activation of reactive oxygen species-inducible protein kinases (p38-MAPK, AMPK)

International Journal of Cancer

Volumn 123, Issue 5, 2008, Pages 1205-1214

  Sánchez, Yolanda ^a   Amrán, Donna ^a,b   Fernández, Carlos ^a   De Blas, Elena ^a   Aller, Patricio ^a  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Apoptosis; Arsenic trioxide; Genistein; Leukemia cells; Protein kinases; Reactive oxygen species

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLCYSTEINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ARSENIC TRIOXIDE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BUTYLATED HYDROXYANISOLE; CASPASE 3; CASPASE 8; CISPLATIN; COMPOUND C; CYTOCHROME C; GENISTEIN; HYDROGEN PEROXIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; N (2 AMINOPHENYL) 4 (3 PYRIDINYLMETHOXYCARBONYLAMINOMETHYL)BENZAMIDE; PROTEIN BCL XL; PROTEIN BID; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; X LINKED INHIBITOR OF APOPTOSIS; AMP ACTIVATED PROTEIN KINASES; AMP-ACTIVATED PROTEIN KINASES; ANTINEOPLASTIC AGENT; MULTIENZYME COMPLEX; ORGANOARSENIC DERIVATIVE; OXIDE; PROTEIN SERINE THREONINE KINASE;

ANTILEUKEMIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BINDING AFFINITY; CANCER CELL DESTRUCTION; CELL STRAIN HL 60; CELL STRAIN U937; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; OXIDATIVE STRESS; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; ENZYME ACTIVATION; ENZYMOLOGY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; IMMUNOBLOTTING; LEUKEMIA; METABOLISM; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; ARSENICALS; CELL LINE, TUMOR; DRUG SYNERGISM; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GENISTEIN; HL-60 CELLS; HUMANS; IMMUNOBLOTTING; JURKAT CELLS; LEUKEMIA; MULTIENZYME COMPLEXES; OXIDATIVE STRESS; OXIDES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; REACTIVE OXYGEN SPECIES; U937 CELLS;

EID: 47249154397     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.23639     Document Type: Article

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