Hispidulin potently inhibits human glioblastoma multiforme cells through activation of AMP-activated protein kinase (AMPK)

Journal of Agricultural and Food Chemistry

Volumn 58, Issue 17, 2010, Pages 9511-9517

  Lin, Ying Chao ^a,b   Hung, Chao Ming ^c   Tsai, Jia Chun ^d   Lee, Jang Chang ^d   Chen, Yi Lin Sophia ^e   Wei, Chyou Wei ^f   Kao, Jung Yie ^a   Way, Tzong Der ^d  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^b BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

^c I SHOU UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

^e NATIONAL ILAN UNIVERSITY   (Taiwan)

^f HUNGKUANG UNIVERSITY   (Taiwan)

Author keywords

AMPK; glioblastoma multiforme; Hispidulin; Saussurea involucrate Kar. et Kir.; traditional Chinese medicine

Indexed keywords

AMPK; GLIOBLASTOMA MULTIFORME; HISPIDULIN; SAUSSUREA INVOLUCRATE KAR. ET KIR.; TRADITIONAL CHINESE MEDICINE;

ANTIBIOTICS; CELL DEATH; CELL PROLIFERATION; ENZYME ACTIVITY; ENZYMES; FATTY ACIDS; MAMMALS;

MEDICINE;

FLAVONE DERIVATIVE; HISPIDULIN; PROTEIN KINASE B;

APOPTOSIS; ARTICLE; BRAIN TUMOR; CELL DIVISION; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; GLIOBLASTOMA; HUMAN; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

APOPTOSIS; BRAIN NEOPLASMS; CELL DIVISION; CELL LINE, TUMOR; ENZYME ACTIVATION; FLAVONES; GLIOBLASTOMA; HUMANS; PROTO-ONCOGENE PROTEINS C-AKT;

EUKARYOTA; MAMMALIA; SAUSSUREA;

EID: 77956245936     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf1019533     Document Type: Article

References (30)

1. Furnari, F. B.; Fenton, T.; Bachoo, R. M.; Mukasa, A.; Stommel, J. M.; Stegh, A.; Hahn, W. C.; Ligon, K. L.; Louis, D. N.; Brennan, C.; Chin, L.; DePinho, R. A.; Cavenee, W. K. Malignant astrocytic glioma: Genetics, biology, and paths to treatment Genes Dev. 2007, 21, 2683-2710
2. Stupp, R.; Hegi, M. E.; Mason, W. P.; van den Bent, M. J.; Taphoorn, M. J.; Janzer, R. C.; Ludwin, S. K.; Allgeier, A.; Fisher, B.; Belanger, K.; Hau, P.; Brandes, A. A.; Gijtenbeek, J.; Marosi, C.; Vecht, C. J.; Mokhtari, K.; Wesseling, P.; Villa, S.; Eisenhauer, E.; Gorlia, T.; Weller, M.; Lacombe, D.; Cairncross, J. G.; Mirimanoff, R. O. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial Lancet Oncol. 2009, 10, 459-466
3. Koubova, J.; Guarente, L. How does calorie restriction work? Genes 2003, 17, 313-321
4. Cabelof, D. C.; Yanamadala, S.; Raffoul, J. J.; Guo, Z.; Soofi, A.; Heydari, A. R. Caloric restriction promotes genomic stability by induction of base excision repair and reversal of its age-related decline DNA Repair 2003, 2, 295-307
5. Fogarty, S.; Hardie, D. G. Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer Biochim. Biophys. Acta 2010, 1804, 581-591
6. Wang, X.; Beugnet, A.; Murakami, M.; Yamanaka, S.; Proud, C. G. Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins Mol. Cell. Biol. 2005, 25, 2558-2572
7. Faivre, S.; Kroemer, G.; Raymond, E. Current development of mTOR inhibitors as anticancer agents Nat. Rev. Drug Discovery 2006, 5, 671-688
8. Menendez, J. A.; Vazquez-Martin, A.; Ortega, F. J.; Fernandez-Real, J. M. Fatty acid synthase: Association with insulin resistance, type 2 diabetes, and cancer Clin. Chem. 2009, 55, 425-438
9. Menendez, J. A.; Lupu, R. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis Nat. Rev. Cancer 2007, 7, 763-777
10. Milgraum, L. Z.; Witters, L. A.; Pasternack, G. R.; Kuhajda, F. P. Enzymes of the fatty acid synthase pathway are highly expressed in in situ breast carcinoma Clin. Cancer Res. 1997, 3, 2115-2120
11. Way, T. D.; Lee, J. C.; Kuo, D. H.; Fan, L. L.; Huang, C. H.; Lin, H. Y.; Shieh, P. C.; Kuo, P. T.; Liao, C. F.; Liu, H.; Kao, J. Y. Inhibition of epidermal growth factor receptor signaling by Saussurea involucrata, a rare traditional Chinese medicinal herb, in human hormone-resistant prostate cancer PC-3 cells J. Agric. Food Chem. 2010, 58, 3356-3365
12. Chulasiri, M.; Bunyapraphatsara, N.; Moongkarndi, P. Mutagenicity and antimutagenicity of hispidulin and hortensin, the flavonoids from Millingtonia hortensis L Environ. Mol. Mutagen. 1992, 20, 307-312
13. Tan, R. X.; Lu, H.; Wolfender, J. L.; Yu, T. T.; Zheng, W. F.; Yang, L.; Gafner, S.; Hostettmann, K. Mono- and sesquiterpenes and antifungal constituents from Artemisia species Planta Med. 1999, 65, 64-67
14. Gil, B.; Sanz, M. J.; Terencio, M. C.; Ferrándiz, M. L.; Bustos, G.; Payá, M.; Gunasegaran, R.; Alcaraz, M. J. Effects of flavonoids on Naja naja and human recombinant synovial phospholipases A2 and inflammatory responses in mice Life Sci. 1994, 54, 333-338
15. Kavvadias, D.; Monschein, V.; Sand, P.; Riederer, P.; Schreier, P. Constituents of sage (Salvia officinalis L.) with in vitro affinity to human brain benzodiazepine receptor Planta Med. 2003, 69, 113-117
16. Kavvadias, D.; Sand, P.; Youdim, K. A.; Qaiser, M. Z.; Rice-Evans, C.; Baur, R.; Sigel, E.; Rausch, W. D.; Riederer, P.; Schreier, P. The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects Br. J. Pharmacol. 2004, 142, 811-820
17. Lin, V. C.; Chou, C. H.; Lin, Y. C.; Lin, J. N.; Yu, C. C.; Tang, C. H.; Lin, H. Y.; Way, T. D. Osthole suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt/mTOR pathway J. Agric. Food Chem. 2010, 58, 4786-4793
18. Lin, J. N.; Lin, V. C.; Rau, K. M.; Shieh, P. C.; Kuo, D. H.; Shieh, J. C.; Chen, W. J.; Tsai, S. C.; Way, T. D. Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation J. Agric. Food Chem. 2010, 58, 1584-1592
19. Li, J. N.; Gorospe, M.; Chrest, F. J.; Kumaravel, T. S.; Evans, M. K.; Han, W. F.; Pizer, E. S. Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53 Cancer Res. 2001, 61, 1493-1499
20. Motoshima, H.; Goldstein, B. J.; Igata, M.; Araki, E. AMPK and cell proliferation - AMPK as a therapeutic target for atherosclerosis and cancer J. Physiol. 2006, 574, 63-71
21. Kimball, S. R. Interaction between the AMP-activated protein kinase and mTOR signaling pathways Med. Sci. Sports Exercise 2006, 38, 1958-1964
22. Carrera, A. C. TOR signaling in mammals J. Cell Sci. 2004, 117, 4615-4616
23. Williams, T.; Brenman, J. E. LKB1 and AMPK in cell polarity and division Trends Cell Biol. 2008, 18, 193-198
24. Hardie, D. G. Minireview: The AMP-activated protein kinase cascade: The key sensor of cellular energy status Endocrinology 2003, 144, 5179-5183
25. Swinnen, J. V.; Beckers, A.; Brusselmans, K.; Organe, S.; Segers, J.; Timmermans, L.; Vanderhoydonc, F.; Deboel, L.; Derua, R.; Waelkens, E.; De Schrijver, E.; Van de Sande, T.; No l, A.; Foufelle, F.; Verhoeven, G. Mimicry of a cellular low energy status blocks tumor cells anabolism and suppresses the malignant phenotype Cancer Res. 2005, 65, 2441-2448
26. Jones, R. G.; Plas, D. R.; Kubek, S.; Buzzai, M.; Mu, J.; Xu, Y.; Birnbaum, M. J.; Thompson, C. B. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint Mol. Cell 2005, 18, 283-293
27. Hardie, D. G.; Carling, D.; Carlson, M. The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell? Annu. Rev. Biochem. 1998, 67, 821-855
28. Yun, H.; Lee, M.; Kim, S. S.; Ha, J. Glucose deprivation increases mRNA stability of vascular endothelial growth factor through activation of AMP-activated protein kinase in DU145 prostate carcinoma J. Biol. Chem. 2005, 280, 9963-9972
29. Luo, Z.; Saha, A. K.; Xiang, X.; Ruderman, N. B. AMPK, the metabolic syndrome and cancer Trends Pharmacol. Sci. 2005, 26, 69-76
30. Jones, R. G.; Plas, D. R.; Kubek, S.; Buzzai, M.; Mu, J.; Xu, Y.; Birnbaum, M. J.; Thompson, C. B. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint Mol. Cell 2005, 18, 283-293