Regulation of mutual inhibitory activities between AMPK and Akt with quercetin in MCF-7 breast cancer cells

Oncology Reports

Volumn 24, Issue 6, 2010, Pages 1493-1497

  Lee, Yun Kyoung ^a   Park, Ock Jin ^a  

^a Hannam University Daedeok Valley Campus ^*  (South Korea)

Author keywords

Akt; AMP activated protein kinase; MCF 7 breast cancer cells; Mutual inhibition; Quercetin

Indexed keywords

ADENYLATE KINASE; BETA ACTIN; PROTEIN KINASE B; QUERCETIN; SMALL INTERFERING RNA;

ARTICLE; BREAST CANCER; CANCER INHIBITION; CELL NUCLEUS; CELL STRAIN MCF 7; CELL SURVIVAL; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME REPRESSION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ADENYLATE KINASE; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CARCINOMA; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FEMALE; HUMANS; MODELS, BIOLOGICAL; ONCOGENE PROTEIN V-AKT; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; QUERCETIN; RNA, SMALL INTERFERING;

EID: 78649440083     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or-00001010     Document Type: Article

References (21)

1. Carnero A: The PKB/AKT pathway in cancer. Curr Pharm Des 16: 34-44, 2010.
2. Bhaskar PT and Hay N: The two TORCs and Akt. Dev Cell 12: 487-502, 2007.
3. Tokunaga E, Oki E, Egashira A, et al: Deregulation of the Akt pathway in human cancer. Curr Cancer Drug Targets 8: 27-36, 2008.
4. Frech M, Andjelkovic M, Ingley E, Reddy KK, Falck JR and Hemmings BA: High affinity binding of inositol phosphates and phosphoinositides to the pleckstrin homology domain of RAC/protein kinase B and their influence on kinase activity. J Biol Chem 272: 8474-8481, 1997. (Pubitemid 27147810)
5. Ghayad SE and Cohen PA: Inhibitors of the PI3K/Akt/mTOR pathway: new hope for breast cancer patients. Recent Pat Anticancer Drug Discov 5: 29-57, 2010.
6. Cicenas J: The potential role of Akt phosphorylation in human cancers. Int J Biol Markers 23: 1-9, 2008.
7. Yang SX, Costantino JP, Kim C, et al: Akt phosphorylation at Ser473 predicts benefit of paclitaxel chemotherapy in nodepositive breast cancer. J Clin Oncol 28: 2974-2981, 2010.
8. Mitsiades CS, Mitsiades N and Koutsilieris M: The Akt pathway: molecular targets for anti-cancer drug development. Curr Cancer Drug Targets 4: 235-256, 2004.
9. Wang X, Chen W and Lin Y: Sensitization of TNF-induced cytotoxicity in lung cancer cells by concurrent suppression of the NF-kappaB and Akt pathways. Biochem Biophys Res Commun 355: 807-812, 2007.
10. Eto I: Upstream molecular signaling pathways of p27(Kip1) expression: effects of 4-hydroxytamoxifen, dexamethasone, and retinoic acids. Cancer Cell Int 10: 3, 2010.
11. Kim KY, Baek A, Hwang JE, et al: Adiponectin-activated AMPK stimulates dephosphorylation of AKT through protein phosphatase 2A activation. Cancer Res 69: 4018-4026, 2009.
12. Zakikhani M, Blouin MJ, Piura E and Pollak MN: Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells. Breast Cancer Res Treat 123: 271-279, 2010.
13. Hahn-Windgassen A, Nogueira V, Chen CC, Skeen JE, Sonenberg N and Hay N: Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. J Biol Chem 280: 32081-32089, 2005.
14. Kim YH and Lee YJ: TRAIL apoptosis is enhanced by quercetin through Akt dephosphorylation. J Cell Biochem 100: 998-1009, 2007.
15. Granado-Serrano AB, Angeles Martin M, Bravo L, Goya L and Ramos S: Time-course regulation of quercetin on cell survival/ proliferation pathways in human hepatoma cells. Mol Nutr Food Res 52: 457-464, 2008.
16. Zhang Q, Zhao XH and Wang ZJ: Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis. Food Chem Toxicol 46: 2042-2053, 2008.
17. Park CH, Chang JY, Hahm ER, Park S, Kim HK and Yang CH: Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells. Biochem Biophys Res Commun 328: 227-234, 2005.
18. Lee YK, Park SY, Kim YM, Lee WS and Park OJ: AMP kinase/cyclooxygenase-2 pathway regulates proliferation and apoptosis of cancer cells treated with quercetin. Exp Mol Med 41: 201-207, 2009.
19. Waite KA, Sinden MR and Eng C: Phytoestrogen exposure elevates PTEN levels. Hum Mol Genet 14: 1457-1463, 2005.
20. Huang X, Wullschleger S, Shpiro N, et al: Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice. Biochem J 412: 211-221, 2008.
21. Kovacic S, Soltys CL, Barr AJ, Shiojima I, Walsh K and Dyck JR: Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart. J Biol Chem 278: 39422-39427, 2003.