메뉴 건너뛰기




Volumn 41, Issue 16, 2013, Pages 7589-7605

DNA double-strand-break complexity levels and their possible contributions to the probability for error-prone processing and repair pathway choice

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DNA FRAGMENT; HYDROGEN PEROXIDE; RESTRICTION ENDONUCLEASE;

EID: 84886806613     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkt556     Document Type: Article
Times cited : (228)

References (157)
  • 2
    • 0024266655 scopus 로고
    • Induction and rejoining of gamma-ray-induced DNA single- and doublestrand breaks in Chinese hamster AA8 cells and in two radiosensitive clones
    • van Ankeren,S.C., Murray,D. and Meyn,R.E. (1988) Induction and rejoining of gamma-ray-induced DNA single- and doublestrand breaks in Chinese hamster AA8 cells and in two radiosensitive clones. Radiat. Res., 116, 511-525.
    • (1988) Radiat. Res. , vol.116 , pp. 511-525
    • Van Ankeren, S.C.1    Murray, D.2    Meyn, R.E.3
  • 3
    • 0024558187 scopus 로고
    • UV mutagenesis, cytotoxicity and split-dose recovery in a human-CHO cell hybrid having intermediate (6-4) photoproduct repair
    • Nairn,R.S., Mitchell,D.L., Adair,G.M., Thompson,L.H., Siciliano,M.J. and Humphrey,R.M. (1989) UV mutagenesis, cytotoxicity and split-dose recovery in a human-CHO cell hybrid having intermediate (6-4) photoproduct repair. Mutat. Res., 217, 193-201.
    • (1989) Mutat. Res. , vol.217 , pp. 193-201
    • Nairn, R.S.1    Mitchell, D.L.2    Adair, G.M.3    Thompson, L.H.4    Siciliano, M.J.5    Humphrey, R.M.6
  • 4
    • 84858063571 scopus 로고    scopus 로고
    • Keeping it together in times of stress: Checkpoint function at stalled replication forks
    • Berens,T.J. and Toczyski,D.P. (2012) Keeping it together in times of stress: checkpoint function at stalled replication forks. Mol. Cell, 45, 585-586.
    • (2012) Mol. Cell , vol.45 , pp. 585-586
    • Berens, T.J.1    Toczyski, D.P.2
  • 6
    • 84875229761 scopus 로고    scopus 로고
    • Early replication fragile sites: Where replication-transcription collisions cause genetic instability
    • Mortusewicz,O., Herr,P. and Helleday,T. (2013) Early replication fragile sites: where replication-transcription collisions cause genetic instability. EMBO J., 32, 493-495.
    • (2013) EMBO J. , vol.32 , pp. 493-495
    • Mortusewicz, O.1    Herr, P.2    Helleday, T.3
  • 7
    • 34447320174 scopus 로고    scopus 로고
    • O6-methylguanine- DNA-methyltransferase (MGMT) gene therapy targeting haematopoietic stem cells: Studies addressing safety issues
    • Sorg,U.R., Kleff,V., Fanaei,S., Schumann,A., Moellmann,M., Opalka,B., Thomale,J. and Moritz,T. (2007) O6-methylguanine- DNA-methyltransferase (MGMT) gene therapy targeting haematopoietic stem cells: Studies addressing safety issues. DNA Repair, 6, 1197-1209.
    • (2007) DNA Repair , vol.6 , pp. 1197-1209
    • Sorg, U.R.1    Kleff, V.2    Fanaei, S.3    Schumann, A.4    Moellmann, M.5    Opalka, B.6    Thomale, J.7    Moritz, T.8
  • 8
    • 0034707047 scopus 로고    scopus 로고
    • The DNA damage response: Putting checkpoints in perspective
    • Zhou,B.B. and Elledge,S.J. (2000) The DNA damage response: putting checkpoints in perspective. Nature, 408, 433-439.
    • (2000) Nature , vol.408 , pp. 433-439
    • Zhou, B.B.1    Elledge, S.J.2
  • 9
    • 70350504453 scopus 로고    scopus 로고
    • The DNA-damage response in human biology and disease
    • Jackson,S.P. and Bartek,J. (2009) The DNA-damage response in human biology and disease. Nature, 461, 1071-1078.
    • (2009) Nature , vol.461 , pp. 1071-1078
    • Jackson, S.P.1    Bartek, J.2
  • 10
    • 13444301307 scopus 로고    scopus 로고
    • Mechanism and control of V(D)J recombination versus class switch recombination: Similarities and differences
    • Dudley,D.D., Chaudhuri,J., Bassing,C.H. and Alt,F.W. (2005) Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences. Adv. Immunol., 86, 43-112.
    • (2005) Adv. Immunol. , vol.86 , pp. 43-112
    • Dudley, D.D.1    Chaudhuri, J.2    Bassing, C.H.3    Alt, F.W.4
  • 11
    • 0033855389 scopus 로고    scopus 로고
    • Mechanisms of DNA double-strand break repair and their potential to induce chromosomal aberrations
    • Pfeiffer,P., Goedecke,W. and Obe,G. (2000) Mechanisms of DNA double-strand break repair and their potential to induce chromosomal aberrations. Mutagenesis, 15, 289-302.
    • (2000) Mutagenesis , vol.15 , pp. 289-302
    • Pfeiffer, P.1    Goedecke, W.2    Obe, G.3
  • 12
    • 0001273995 scopus 로고
    • Ionizing radiation damage and its early development in chromosomes
    • Cornforth,M.N. and Bedford,J.S. (1993) Ionizing radiation damage and its early development in chromosomes. Adv. Radiat. Biol., 17, 423-496.
    • (1993) Adv. Radiat. Biol. , vol.17 , pp. 423-496
    • Cornforth, M.N.1    Bedford, J.S.2
  • 15
    • 80755187806 scopus 로고    scopus 로고
    • Double-strand break end resection and repair pathway choice
    • Symington,L.S. and Gautier,J. (2011) Double-strand break end resection and repair pathway choice. Annu. Rev. Genet., 45, 247-271.
    • (2011) Annu. Rev. Genet. , vol.45 , pp. 247-271
    • Symington, L.S.1    Gautier, J.2
  • 16
    • 77953229115 scopus 로고    scopus 로고
    • The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
    • Lieber,M.R. (2010) The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu. Rev. Biochem., 79, 181-211.
    • (2010) Annu. Rev. Biochem. , vol.79 , pp. 181-211
    • Lieber, M.R.1
  • 17
    • 0025836802 scopus 로고
    • Sublethal damage, potentially lethal damage, and chromosomal aberrations in mammalian cells exposed to ionizing radiations
    • Bedford,J.S. (1991) Sublethal damage, potentially lethal damage, and chromosomal aberrations in mammalian cells exposed to ionizing radiations. Int. J. Radiat. Oncol. Biol. Phys., 21, 1457-1469.
    • (1991) Int. J. Radiat. Oncol. Biol. Phys. , vol.21 , pp. 1457-1469
    • Bedford, J.S.1
  • 18
    • 0003154759 scopus 로고
    • Sites of radiation induced chromosome exchanges
    • Savage,J.R.K. (1970) Sites of radiation induced chromosome exchanges. Curr. Top. Radiat. Res., 6, 129-194.
    • (1970) Curr. Top. Radiat. Res. , vol.6 , pp. 129-194
    • Savage, J.R.K.1
  • 19
    • 0035839840 scopus 로고    scopus 로고
    • DNA double strand break repair and chromosomal translocation: Lessons from animal models
    • Ferguson,D.O. and Alt,F.W. (2001) DNA double strand break repair and chromosomal translocation: lessons from animal models. Oncogene, 20, 5572-5579.
    • (2001) Oncogene , vol.20 , pp. 5572-5579
    • Ferguson, D.O.1    Alt, F.W.2
  • 21
    • 0029612225 scopus 로고
    • Repair of x-ray-induced DNA double-strand breaks in specific Not i restriction fragments in human fibroblasts: Joining of correct and incorrect ends
    • Löbrich,M., Rydberg,B. and Cooper,P.K. (1995) Repair of x-ray-induced DNA double-strand breaks in specific Not I restriction fragments in human fibroblasts: joining of correct and incorrect ends. Proc. Natl Acad. Sci. USA, 92, 12050-12054.
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 12050-12054
    • Löbrich, M.1    Rydberg, B.2    Cooper, P.K.3
  • 22
    • 2142712163 scopus 로고    scopus 로고
    • No dosedependence of DNA double-strand break misrejoining following a-particle irradiation
    • Kühne,M., Rothkamm,K. and Löbrich,M. (2000) No dosedependence of DNA double-strand break misrejoining following a-particle irradiation. Int. J. Radiat. Biol., 76, 891-900.
    • (2000) Int. J. Radiat. Biol. , vol.76 , pp. 891-900
    • Kühne, M.1    Rothkamm, K.2    Löbrich, M.3
  • 24
    • 77952108629 scopus 로고    scopus 로고
    • Small scale genetic alterations contribute to increased mutability at the X-linked Hprt locus in vivo in Blm hypomorphic mice
    • Tereshchenko,I.V., Chen,Y., McDaniel,L.D., Schultz,R.A., Tischfield,J.A. and Shao,C. (2010) Small scale genetic alterations contribute to increased mutability at the X-linked Hprt locus in vivo in Blm hypomorphic mice. DNA Repair, 9, 551-557.
    • (2010) DNA Repair , vol.9 , pp. 551-557
    • Tereshchenko, I.V.1    Chen, Y.2    McDaniel, L.D.3    Schultz, R.A.4    Tischfield, J.A.5    Shao, C.6
  • 28
    • 80054679198 scopus 로고    scopus 로고
    • Heterochromatin maintenance and establishment: Lessons from the mouse pericentromere
    • Almouzni,G. and Probst,A.V. (2011) Heterochromatin maintenance and establishment: lessons from the mouse pericentromere. Nucleus, 2, 332-338.
    • (2011) Nucleus , vol.2 , pp. 332-338
    • Almouzni, G.1    Probst, A.V.2
  • 29
  • 30
    • 84880544586 scopus 로고    scopus 로고
    • Induction and repair of clustered DNA lesions: What do we know so far?
    • Georgakilas,A.G., O'Neill,P. and Stewart,R.D. (2012) Induction and repair of clustered DNA lesions: what do we know so far? Radiat. Res., 180, 100-109.
    • (2012) Radiat. Res. , vol.180 , pp. 100-109
    • Georgakilas, A.G.1    O'neill, P.2    Stewart, R.D.3
  • 31
    • 80655127826 scopus 로고    scopus 로고
    • The role of homologous recombination in radiation-induced double-strand break repair
    • Jeggo,P.A., Geuting,V. and Löbrich,M. (2011) The role of homologous recombination in radiation-induced double-strand break repair. Radiother. Oncol., 101, 7-12.
    • (2011) Radiother. Oncol. , vol.101 , pp. 7-12
    • Jeggo, P.A.1    Geuting, V.2    Löbrich, M.3
  • 32
    • 84856287453 scopus 로고    scopus 로고
    • DNA double-strand break repair within heterochromatic regions
    • Murray,J.M., Stiff,T. and Jeggo,P.A. (2012) DNA double-strand break repair within heterochromatic regions. Biochem. Soc. Trans., 40, 173-178.
    • (2012) Biochem. Soc. Trans. , vol.40 , pp. 173-178
    • Murray, J.M.1    Stiff, T.2    Jeggo, P.A.3
  • 33
    • 84876188716 scopus 로고    scopus 로고
    • Transcription-replication encounters, consequences and genomic instability
    • Helmrich,A., Ballarino,M., Nudler,E. and Tora,L. (2013) Transcription-replication encounters, consequences and genomic instability. Nat. Struct. Mol. Biol., 20, 412-418.
    • (2013) Nat. Struct. Mol. Biol. , vol.20 , pp. 412-418
    • Helmrich, A.1    Ballarino, M.2    Nudler, E.3    Tora, L.4
  • 34
    • 0022378745 scopus 로고
    • The chromosome-breaking activity of the restriction endonuclease Alu i in CHO cells is independent of the S-phase of the cell cycle
    • Obe,G. and Winkel,E.-U. (1985) The chromosome-breaking activity of the restriction endonuclease Alu I in CHO cells is independent of the S-phase of the cell cycle. Mutat. Res., 152, 25-29.
    • (1985) Mutat. Res. , vol.152 , pp. 25-29
    • Obe, G.1    Winkel, E.-U.2
  • 35
    • 0027462474 scopus 로고
    • Restriction-endonucleaseinduced DNA double-strand breaks and chromosomal aberrations in mammalian cells
    • Bryant,P.E. and Johnston,P.J. (1993) Restriction-endonucleaseinduced DNA double-strand breaks and chromosomal aberrations in mammalian cells. Mutat. Res., 299, 289-296.
    • (1993) Mutat. Res. , vol.299 , pp. 289-296
    • Bryant, P.E.1    Johnston, P.J.2
  • 36
    • 79952279926 scopus 로고    scopus 로고
    • The fractal globule as a model of chromatin architecture in the cell
    • Mirny,L. (2011) The fractal globule as a model of chromatin architecture in the cell. Chromosome Res., 19, 37-51.
    • (2011) Chromosome Res. , vol.19 , pp. 37-51
    • Mirny, L.1
  • 37
    • 84867498711 scopus 로고    scopus 로고
    • A fractal model for nuclear organization: Current evidence and biological implications
    • Bancaud,A., Lavelle,C., Huet,S. and Ellenberg,J. (2012) A fractal model for nuclear organization: current evidence and biological implications. Nucleic Acids Res., 40, 8783-8792.
    • (2012) Nucleic Acids Res. , vol.40 , pp. 8783-8792
    • Bancaud, A.1    Lavelle, C.2    Huet, S.3    Ellenberg, J.4
  • 38
    • 16644373413 scopus 로고    scopus 로고
    • Analysis of double-strand break repair by non-homologous DNA end joining in cell-free extracts from mammalian cells
    • Pfeiffer,P., Feldmann,E., Odersky,A., Kuhfittig-Kulle,S. and Goedecke,W. (2005) Analysis of double-strand break repair by non-homologous DNA end joining in cell-free extracts from mammalian cells. Methods Mol. Biol., 291, 351-371.
    • (2005) Methods Mol. Biol. , vol.291 , pp. 351-371
    • Pfeiffer, P.1    Feldmann, E.2    Odersky, A.3    Kuhfittig-Kulle, S.4    Goedecke, W.5
  • 39
    • 36949012967 scopus 로고    scopus 로고
    • Non-homologous end-joining, a sticky affair
    • van Gent,D.C. and van der Burg,M. (2007) Non-homologous end-joining, a sticky affair. Oncogene, 26, 7731-7740.
    • (2007) Oncogene , vol.26 , pp. 7731-7740
    • Van Gent, D.C.1    Van Der Burg, M.2
  • 41
    • 77951498531 scopus 로고    scopus 로고
    • High-resolution profiling of gH2AX around DNA double strand breaks in the mammalian genome
    • Iacovoni,J.S., Caron,P., Lassadi,I., Nicolas,E., Massip,L., Trouche,D. and Legube,G. (2010) High-resolution profiling of gH2AX around DNA double strand breaks in the mammalian genome. EMBO J., 29, 1446-1457.
    • (2010) EMBO J. , vol.29 , pp. 1446-1457
    • Iacovoni, J.S.1    Caron, P.2    Lassadi, I.3    Nicolas, E.4    Massip, L.5    Trouche, D.6    Legube, G.7
  • 42
    • 0029899891 scopus 로고    scopus 로고
    • Genetic manipulation of genomes with rarecutting endonucleases
    • Jasin,M. (1996) Genetic manipulation of genomes with rarecutting endonucleases. Trends Genet., 12, 224-228.
    • (1996) Trends Genet. , vol.12 , pp. 224-228
    • Jasin, M.1
  • 43
    • 84868592402 scopus 로고    scopus 로고
    • I-SceI-based assays to examine distinct repair outcomes of mammalian chromosomal double strand-breaks
    • Gunn,A. and Stark,J.M. (2012) I-SceI-based assays to examine distinct repair outcomes of mammalian chromosomal double strand-breaks. Methods Mol. Biol., 920, 379-391.
    • (2012) Methods Mol. Biol. , vol.920 , pp. 379-391
    • Gunn, A.1    Stark, J.M.2
  • 44
    • 45849117573 scopus 로고    scopus 로고
    • Activation of the cellular DNA damage response in the absence of DNA lesions
    • Soutoglou,E. and Misteli,T. (2008) Activation of the cellular DNA damage response in the absence of DNA lesions. Science, 320, 1507-1510.
    • (2008) Science , vol.320 , pp. 1507-1510
    • Soutoglou, E.1    Misteli, T.2
  • 45
    • 84878822000 scopus 로고    scopus 로고
    • Development of an assay to measure mutagenic non-homologous end-joining repair activity in mammalian cells
    • Bindra,R.S., Goglia,A.G., Jasin,M. and Powell,S.N. (2013) Development of an assay to measure mutagenic non-homologous end-joining repair activity in mammalian cells. Nucleic Acids Res., 41, e115.
    • (2013) Nucleic Acids Res. , vol.41
    • Bindra, R.S.1    Goglia, A.G.2    Jasin, M.3    Powell, S.N.4
  • 46
    • 44349143334 scopus 로고    scopus 로고
    • Heavy ion carcinogenesis and human space exploration
    • Durante,M. and Cucinotta,F.A. (2008) Heavy ion carcinogenesis and human space exploration. Nat. Rev. Cancer, 8, 465-472.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 465-472
    • Durante, M.1    Cucinotta, F.A.2
  • 47
  • 48
  • 49
    • 79956189193 scopus 로고    scopus 로고
    • Track structures, DNA targets and radiation effects in the biophysical Monte Carlo simulation code PARTRAC
    • Friedland,W., Dingfelder,M., Kundrát,P. and Jacob,P. (2011) Track structures, DNA targets and radiation effects in the biophysical Monte Carlo simulation code PARTRAC. Mutat. Res., 711, 28-40.
    • (2011) Mutat. Res. , vol.711 , pp. 28-40
    • Friedland, W.1    Dingfelder, M.2    Kundrát, P.3    Jacob, P.4
  • 50
    • 0022312389 scopus 로고
    • Biochemistry of DNA lesions
    • Ward,J.F. (1985) Biochemistry of DNA lesions. Radiat. Res., 104, S103-S111.
    • (1985) Radiat. Res. , vol.104
    • Ward, J.F.1
  • 51
    • 0025282247 scopus 로고
    • The yield of DNA double-strand breaks produced intracellularly by ionizing radiation: A review
    • Ward,J.F. (1990) The yield of DNA double-strand breaks produced intracellularly by ionizing radiation: a review. Int. J. Radiat. Biol., 57, 1141-1150.
    • (1990) Int. J. Radiat. Biol. , vol.57 , pp. 1141-1150
    • Ward, J.F.1
  • 52
    • 0020354447 scopus 로고
    • Sites and structure of g radiation-induced DNA strand breaks
    • Henner,W.D., Grunberg,S.M. and Haseltine,W.A. (1982) Sites and structure of g radiation-induced DNA strand breaks. J. Biol. Chem., 257, 11750-11754.
    • (1982) J. Biol. Chem. , vol.257 , pp. 11750-11754
    • Henner, W.D.1    Grunberg, S.M.2    Haseltine, W.A.3
  • 54
    • 79955663428 scopus 로고    scopus 로고
    • Tidying up loose ends: The role of polynucleotide kinase/phosphatase in DNA strand break repair
    • Weinfeld,M., Mani,R.S., Abdou,I., Aceytuno,R.D. and Glover,J.N.M. (2011) Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair. Trends Biochem. Sci., 36, 262-271.
    • (2011) Trends Biochem. Sci. , vol.36 , pp. 262-271
    • Weinfeld, M.1    Mani, R.S.2    Abdou, I.3    Aceytuno, R.D.4    Glover, J.N.M.5
  • 55
    • 0022259419 scopus 로고
    • Mammalian cells are not killed by DNA single-strand breaks caused by hydroxyl radiacals from hydrogen peroxide
    • Ward,J.F., Blakely,W.F. and Joner,E.I. (1985) Mammalian cells are not killed by DNA single-strand breaks caused by hydroxyl radiacals from hydrogen peroxide. Radiat. Res., 103, 383-392.
    • (1985) Radiat. Res. , vol.103 , pp. 383-392
    • Ward, J.F.1    Blakely, W.F.2    Joner, E.I.3
  • 56
    • 0026612327 scopus 로고
    • Induction by H2O2 of DNA and interphase chromosome damage in plateau phase CHO cells
    • Iliakis,G.E., Pantelias,G.E., Okayasu,R. and Blakely,W.F. (1992) Induction by H2O2 of DNA and interphase chromosome damage in plateau phase CHO cells. Radiat. Res., 131, 193-203.
    • (1992) Radiat. Res. , vol.131 , pp. 193-203
    • Iliakis, G.E.1    Pantelias, G.E.2    Okayasu, R.3    Blakely, W.F.4
  • 57
    • 0033957577 scopus 로고    scopus 로고
    • Comparison of biological effects of DNA damage induced by ionizing radiation and hydrogen peroxide in CHO cells
    • Dahm-Daphi,J., Sass,C. and Alberti,W. (2000) Comparison of biological effects of DNA damage induced by ionizing radiation and hydrogen peroxide in CHO cells. Int. J. Radiat. Biol., 76, 67-75.
    • (2000) Int. J. Radiat. Biol. , vol.76 , pp. 67-75
    • Dahm-Daphi, J.1    Sass, C.2    Alberti, W.3
  • 58
    • 0029075224 scopus 로고
    • Molecular and cell models of biological effects of heavy ion radiation
    • Goodhead,D.T. (1995) Molecular and cell models of biological effects of heavy ion radiation. Radiat. Environ. Biophys., 34, 67-72.
    • (1995) Radiat. Environ. Biophys. , vol.34 , pp. 67-72
    • Goodhead, D.T.1
  • 59
    • 0003605672 scopus 로고    scopus 로고
    • 6th Edn. Lippincott Williams & Wilkins, Philadelphia, Baltimore, New York, London, Buenos Aires, Hong Kong, Sydney, Tokyo
    • Hall,E.J. and Giaccia,A.J. (2006) Radiobiology for the Radiologist, 6th Edn. Lippincott Williams & Wilkins, Philadelphia, Baltimore, New York, London, Buenos Aires, Hong Kong, Sydney, Tokyo.
    • (2006) Radiobiology for the Radiologist
    • Hall, E.J.1    Giaccia, A.J.2
  • 60
    • 0002078793 scopus 로고
    • Chapter 2. In: Freeman,G.R. (ed.), Kinetics of Nonhomogeneous Processes. John Wiley & Sons, Inc
    • Paretzke,H.G. (1987) Radiation track structure theory. Chapter 2. In: Freeman,G.R. (ed.), Kinetics of Nonhomogeneous Processes. John Wiley & Sons, Inc., pp. 89-170.
    • (1987) Radiation Track Structure Theory , pp. 89-170
    • Paretzke, H.G.1
  • 61
    • 77951782095 scopus 로고    scopus 로고
    • Stochastic simulation of DNA double-strand break repair by nonhomologous end joining based on track structure calculations
    • Friedland,W., Jacob,P. and Kundrát,P. (2010) Stochastic simulation of DNA double-strand break repair by nonhomologous end joining based on track structure calculations. Radiat. Res., 173, 677-688.
    • (2010) Radiat. Res. , vol.173 , pp. 677-688
    • Friedland, W.1    Jacob, P.2    Kundrát, P.3
  • 62
    • 0024195429 scopus 로고
    • DNA damage produced by ionizing radiation in mammalian cells: Identities, mechanisms of formation, and reparability
    • Ward,J.F. (1988) DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability. Prog. Nucleic Acid Res. Mol. Biol., 35, 95-125.
    • (1988) Prog. Nucleic Acid Res. Mol. Biol. , vol.35 , pp. 95-125
    • Ward, J.F.1
  • 63
    • 0024556574 scopus 로고
    • Track structure analysis of ultrasoft X-rays compared to high- and low-LET radiations
    • Goodhead,D.T. and Nikjoo,H. (1989) Track structure analysis of ultrasoft X-rays compared to high- and low-LET radiations. Int. J. Radiat. Biol., 55, 513-529.
    • (1989) Int. J. Radiat. Biol. , vol.55 , pp. 513-529
    • Goodhead, D.T.1    Nikjoo, H.2
  • 64
    • 79956197259 scopus 로고    scopus 로고
    • Heavy charged particle radiobiology: Using enhanced biological effectiveness and improved beam focusing to advance cancer therapy
    • Allen,C., Borak,T.B., Tsujii,H. and Nickoloff,J.A. (2011) Heavy charged particle radiobiology: using enhanced biological effectiveness and improved beam focusing to advance cancer therapy. Mutat. Res., 711, 150-157.
    • (2011) Mutat. Res. , vol.711 , pp. 150-157
    • Allen, C.1    Borak, T.B.2    Tsujii, H.3    Nickoloff, J.A.4
  • 65
    • 0023240996 scopus 로고
    • Radiation and hydrogen peroxide induced free radical damage to DNA
    • Ward,J.F., Evans,J.W., Limoli,C.L. and Calabro-Jones,P.M. (1987) Radiation and hydrogen peroxide induced free radical damage to DNA. Br. J. Cancer, 55, 105-112.
    • (1987) Br. J. Cancer , vol.55 , pp. 105-112
    • Ward, J.F.1    Evans, J.W.2    Limoli, C.L.3    Calabro-Jones, P.M.4
  • 66
    • 0034602643 scopus 로고    scopus 로고
    • Clustered DNA damages induced in isolated DNA and in human cells by low doses of ionizing radiation
    • Sutherland,B.M., Bennett,P.V., Sidorkina,O. and Laval,J. (2000) Clustered DNA damages induced in isolated DNA and in human cells by low doses of ionizing radiation. Proc. Natl Acad. Sci. USA, 97, 103-108.
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 103-108
    • Sutherland, B.M.1    Bennett, P.V.2    Sidorkina, O.3    Laval, J.4
  • 68
    • 0027976408 scopus 로고
    • Initial events in the cellular effects of ionizing radiations: Clustered damage in DNA
    • Goodhead,D.T. (1994) Initial events in the cellular effects of ionizing radiations: clustered damage in DNA. Int. J. Radiat. Biol., 65, 7-17.
    • (1994) Int. J. Radiat. Biol. , vol.65 , pp. 7-17
    • Goodhead, D.T.1
  • 69
    • 84877824758 scopus 로고    scopus 로고
    • Processing of damaged DNA ends for doublestrand break repair in mammalian cells
    • Article: ID 345805
    • Povirk,L.F. (2012) Processing of damaged DNA ends for doublestrand break repair in mammalian cells. ISRN Mol. Biol., 2012, Article: ID 345805.
    • (2012) ISRN Mol. Biol. , vol.2012
    • Povirk, L.F.1
  • 70
    • 79956225907 scopus 로고    scopus 로고
    • Clustered DNA lesion repair in eukaryotes: Relevance to mutagenesis and cell survival
    • Sage,E. and Harrison,L. (2011) Clustered DNA lesion repair in eukaryotes: relevance to mutagenesis and cell survival. Mutat. Res., 711, 123-133.
    • (2011) Mutat. Res. , vol.711 , pp. 123-133
    • Sage, E.1    Harrison, L.2
  • 72
    • 79956197636 scopus 로고    scopus 로고
    • Delayed repair of radiation induced clustered DNA damage: Friend or foe? Mutat
    • Eccles,L.J., O'Neill,P. and Lomax,M.E. (2011) Delayed repair of radiation induced clustered DNA damage: friend or foe? Mutat. Res., 711, 134-141.
    • (2011) Res. , vol.711 , pp. 134-141
    • Eccles, L.J.1    O'neill, P.2    Lomax, M.E.3
  • 73
    • 46649102827 scopus 로고    scopus 로고
    • Interplay of two major repair pathways in the processing of complex double-strand DNA breaks
    • Dobbs,T.A., Palmer,P., Maniou,Z., Lomax,M.E. and O'Neill,P. (2008) Interplay of two major repair pathways in the processing of complex double-strand DNA breaks. DNA Repair, 7, 1372-1383.
    • (2008) DNA Repair , vol.7 , pp. 1372-1383
    • Dobbs, T.A.1    Palmer, P.2    Maniou, Z.3    Lomax, M.E.4    O'neill, P.5
  • 74
    • 77950360354 scopus 로고    scopus 로고
    • Hierarchy of lesion processing governs the repair, double-strand break formation and mutability of three-lesion clustered DNA damage
    • Eccles,L.J., Lomax,M.E. and O'Neill,P. (2010) Hierarchy of lesion processing governs the repair, double-strand break formation and mutability of three-lesion clustered DNA damage. Nucleic Acids Res., 38, 1123-1134.
    • (2010) Nucleic Acids Res. , vol.38 , pp. 1123-1134
    • Eccles, L.J.1    Lomax, M.E.2    O'neill, P.3
  • 75
    • 38049055871 scopus 로고    scopus 로고
    • Base excision repair processing of abasic site/single-strand break lesions within clustered damage sites associated with XRCC1 deficiency
    • Mourgues,S., Lomax,M.E. and O'Neill,P. (2007) Base excision repair processing of abasic site/single-strand break lesions within clustered damage sites associated with XRCC1 deficiency. Nucleic Acids Res., 35, 7676-7687.
    • (2007) Nucleic Acids Res. , vol.35 , pp. 7676-7687
    • Mourgues, S.1    Lomax, M.E.2    O'neill, P.3
  • 76
    • 73349093475 scopus 로고    scopus 로고
    • Translesion DNA synthesis-assisted non-homologous end-joining of complex double-strand breaks prevents loss of DNA sequences in mammalian cells
    • Covo,S., de Villartay,J.P., Jeggo,P.A. and Livneh,Z. (2009) Translesion DNA synthesis-assisted non-homologous end-joining of complex double-strand breaks prevents loss of DNA sequences in mammalian cells. Nucleic Acids Res., 37, 6737-6745.
    • (2009) Nucleic Acids Res. , vol.37 , pp. 6737-6745
    • Covo, S.1    De Villartay, J.P.2    Jeggo, P.A.3    Livneh, Z.4
  • 77
    • 50849105384 scopus 로고    scopus 로고
    • DNA repair of clustered lesions in mammalian cells: Involvement of nonhomologous end-joining
    • Malyarchuk,S., Castore,R. and Harrison,L. (2008) DNA repair of clustered lesions in mammalian cells: involvement of nonhomologous end-joining. Nucleic Acids Res., 36, 4872-4882.
    • (2008) Nucleic Acids Res. , vol.36 , pp. 4872-4882
    • Malyarchuk, S.1    Castore, R.2    Harrison, L.3
  • 78
    • 0028298448 scopus 로고
    • Effects of postirradiation temperature on the yields of radiation-induced single- and double-strand breakage in SV40 DNA
    • Jones,G.D., Boswell,T.V. and Ward,J.F. (1994) Effects of postirradiation temperature on the yields of radiation-induced single- and double-strand breakage in SV40 DNA. Radiat. Res., 138, 291-296.
    • (1994) Radiat. Res. , vol.138 , pp. 291-296
    • Jones, G.D.1    Boswell, T.V.2    Ward, J.F.3
  • 79
    • 0026647099 scopus 로고
    • Constraints on energy deposition and target size of multiply damaged sites associated with DNA double-strand breaks
    • Brenner,D.J. and Ward,J.F. (1992) Constraints on energy deposition and target size of multiply damaged sites associated with DNA double-strand breaks. Int. J. Radiat. Biol., 61, 737-748.
    • (1992) Int. J. Radiat. Biol. , vol.61 , pp. 737-748
    • Brenner, D.J.1    Ward, J.F.2
  • 80
    • 0018290776 scopus 로고
    • Alkali-labile sites and post-irradiation effects in gamma-irradiated biologically active double-stranded DNA in aqueous solution
    • Lafleur,M.V.M., Woldhuis,J. and Loman,H. (1979) Alkali-labile sites and post-irradiation effects in gamma-irradiated biologically active double-stranded DNA in aqueous solution. Int. J. Radiat. Biol., 36, 241-247.
    • (1979) Int. J. Radiat. Biol. , vol.36 , pp. 241-247
    • Lafleur, M.V.M.1    Woldhuis, J.2    Loman, H.3
  • 81
    • 0029050296 scopus 로고
    • DNA strand breakage is correlated with unaltered base release after gamma irradiation
    • Henle,E.S., Roots,R., Holley,W.R. and Chatterjee,A. (1995) DNA strand breakage is correlated with unaltered base release after gamma irradiation. Radiat. Res., 143, 144-150.
    • (1995) Radiat. Res. , vol.143 , pp. 144-150
    • Henle, E.S.1    Roots, R.2    Holley, W.R.3    Chatterjee, A.4
  • 83
    • 79953141978 scopus 로고    scopus 로고
    • Distinct roles of ape1 protein in the repair of DNA damage induced by ionizing radiation or bleomycin
    • Fung,H. and Demple,B. (2011) Distinct roles of ape1 protein in the repair of DNA damage induced by ionizing radiation or bleomycin. J. Biol. Chem., 286, 4968-4977.
    • (2011) J. Biol. Chem. , vol.286 , pp. 4968-4977
    • Fung, H.1    Demple, B.2
  • 84
    • 0034077890 scopus 로고    scopus 로고
    • Radiation-induced heat-labile sites that convert into DNA double-strand breaks
    • Rydberg,B. (2000) Radiation-induced heat-labile sites that convert into DNA double-strand breaks. Radiat. Res., 153, 805-812.
    • (2000) Radiat. Res. , vol.153 , pp. 805-812
    • Rydberg, B.1
  • 85
    • 0037385724 scopus 로고    scopus 로고
    • Measurement of prompt DNA double-strand breaks in mammalian cells without including heat-labile sites: Results for cells deficient in nonhomologous end joining
    • Stenerlöw,B., Karlsson,K.H., Cooper,B. and Rydberg,B. (2003) Measurement of prompt DNA double-strand breaks in mammalian cells without including heat-labile sites: results for cells deficient in nonhomologous end joining. Radiat. Res., 159, 502-510.
    • (2003) Radiat. Res. , vol.159 , pp. 502-510
    • Stenerlöw, B.1    Karlsson, K.H.2    Cooper, B.3    Rydberg, B.4
  • 86
    • 37849028892 scopus 로고    scopus 로고
    • Extensive ssDNA end formation at DNA double-strand breaks in non-homologous end-joining deficient cells during the S phase
    • Karlsson,K.H. and Stenerlöw,B. (2007) Extensive ssDNA end formation at DNA double-strand breaks in non-homologous end-joining deficient cells during the S phase BMC Mol. Biol., 8, 97.
    • (2007) BMC Mol Biol. , vol.8 , pp. 97
    • Karlsson, K.H.1    Stenerlöw, B.2
  • 87
    • 69949173687 scopus 로고    scopus 로고
    • Extensive repair of DNA double-strand breaks in cells deficient in the DNA-PK dependent pathway of NHEJ after exclusion of heat-labile sites
    • Singh,S.K., Wu,W., Wu,W., Wang,M. and Iliakis,G. (2009) Extensive repair of DNA double-strand breaks in cells deficient in the DNA-PK dependent pathway of NHEJ after exclusion of heat-labile sites. Radiat. Res., 172, 152-164.
    • (2009) Radiat. Res. , vol.172 , pp. 152-164
    • Singh, S.K.1    Wu, W.2    Wu, W.3    Wang, M.4    Iliakis, G.5
  • 88
    • 80455149665 scopus 로고    scopus 로고
    • Postirradiation chemical processing of DNA damage generates double-strand breaks in cells already engaged in repair
    • Singh,S.K., Wang,M., Staudt,C. and Iliakis,G. (2011) Postirradiation chemical processing of DNA damage generates double-strand breaks in cells already engaged in repair. Nucleic Acids Res., 39, 8416-8429.
    • (2011) Nucleic Acids Res. , vol.39 , pp. 8416-8429
    • Singh, S.K.1    Wang, M.2    Staudt, C.3    Iliakis, G.4
  • 89
    • 84875491190 scopus 로고    scopus 로고
    • Reduced contribution of thermally labile sugar lesions to DNA double strand break formation after exposure to heavy ions
    • Singh,S.K., Bencsik-Theilen,A., Mladenov,E., Jakob,B., Taucher- Scholz,G. and Iliakis,G. (2013) Reduced contribution of thermally labile sugar lesions to DNA double strand break formation after exposure to heavy ions. Radiat. Oncol., 8, 77.
    • (2013) Radiat. Oncol. , vol.8 , pp. 77
    • Singh, S.K.1    Bencsik-Theilen, A.2    Mladenov, E.3    Jakob, B.4    Taucher- Scholz, G.5    Iliakis, G.6
  • 91
    • 84866728909 scopus 로고    scopus 로고
    • Chromothripsis and cancer: Causes and consequences of chromosome shattering
    • Forment,J.V., Kaidi,A. and Jackson,S.P. (2012) Chromothripsis and cancer: causes and consequences of chromosome shattering. Nat. Rev. Cancer, 12, 663-670.
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 663-670
    • Forment, J.V.1    Kaidi, A.2    Jackson, S.P.3
  • 94
    • 0030720835 scopus 로고    scopus 로고
    • Higher-order chromatin structure-dependent repair of DNA double-strand breaks: Modeling the elution of DNA from nucleoids
    • Johnston,P.J., Olive,P.L. and Bryant,P.E. (1997) Higher-order chromatin structure-dependent repair of DNA double-strand breaks: modeling the elution of DNA from nucleoids. Radiat. Res., 148, 561-567.
    • (1997) Radiat. Res. , vol.148 , pp. 561-567
    • Johnston, P.J.1    Olive, P.L.2    Bryant, P.E.3
  • 95
    • 0027988569 scopus 로고
    • A component of DNA double-strand break repair is dependent on the spatial orientation of the lesions within the higher-order structures of chromatin
    • Johnston,P.J. and Bryant,P.E. (1994) A component of DNA double-strand break repair is dependent on the spatial orientation of the lesions within the higher-order structures of chromatin. Int. J. Radiat. Biol., 66, 531-536.
    • (1994) Int. J. Radiat. Biol. , vol.66 , pp. 531-536
    • Johnston, P.J.1    Bryant, P.E.2
  • 96
    • 0031833112 scopus 로고    scopus 로고
    • Higher-order chromatin structure-dependent repair of DNA double-strand breaks: Factors affecting elution of DNA from nucleoids
    • Johnston,P.J., MacPhail,S.H., Banáth,J.P. and Olive,P.L. (1998) Higher-order chromatin structure-dependent repair of DNA double-strand breaks: factors affecting elution of DNA from nucleoids. Radiat. Res., 149, 533-542.
    • (1998) Radiat. Res. , vol.149 , pp. 533-542
    • Johnston, P.J.1    Macphail, S.H.2    Banáth, J.P.3    Olive, P.L.4
  • 97
    • 0029664689 scopus 로고    scopus 로고
    • Clusters of DNA damage induced by ionizing radiation: Formation of short DNA fragments1. Theoretical modeling
    • Holley,W.R. and Chatterjee,A. (1996) Clusters of DNA damage induced by ionizing radiation: formation of short DNA fragments. 1. theoretical modeling. Radiat. Res., 145, 188-199.
    • (1996) Radiat. Res. , vol.145 , pp. 188-199
    • Holley, W.R.1    Chatterjee, A.2
  • 98
    • 0030023098 scopus 로고    scopus 로고
    • Clusters of DNA damage induced by ionizing radiation: Formation of short DNA fragments. 11. Experimental detection
    • Rydberg,B. (1996) Clusters of DNA damage induced by ionizing radiation: formation of short DNA fragments. 11. experimental detection. Radiat. Res., 145, 200-209.
    • (1996) Radiat. Res. , vol.145 , pp. 200-209
    • Rydberg, B.1
  • 99
    • 0029860006 scopus 로고    scopus 로고
    • Non-random distrubution of DNA double-strand breaks induced by particle irradiation
    • Löbrich,M., Cooper,P.K. and Rydberg,B. (1996) Non-random distrubution of DNA double-strand breaks induced by particle irradiation. Int. J. Radiat. Biol., 70, 493-503.
    • (1996) Int. J. Radiat. Biol. , vol.70 , pp. 493-503
    • Löbrich, M.1    Cooper, P.K.2    Rydberg, B.3
  • 100
    • 9644277167 scopus 로고    scopus 로고
    • Calculated DNA double-strand break and fragmentation yields after irradiation with He ions
    • Friedland,W., Dingfelder,M., Jacob,P. and Paretzke,H.G. (2005) Calculated DNA double-strand break and fragmentation yields after irradiation with He ions. Radiat. Phys. Chem., 72, 279-286.
    • (2005) Radiat. Phys. Chem. , vol.72 , pp. 279-286
    • Friedland, W.1    Dingfelder, M.2    Jacob, P.3    Paretzke, H.G.4
  • 101
    • 0031854165 scopus 로고    scopus 로고
    • Monte carlo simulation of the production of short DNA fragments by low-linear energy transfer radiation using higherorder DNA models
    • Friedland,W., Jacob,P., Paretzke,H.G. and Stork,T. (1998) Monte carlo simulation of the production of short DNA fragments by low-linear energy transfer radiation using higherorder DNA models. Radiat. Res., 150, 170-182.
    • (1998) Radiat. Res. , vol.150 , pp. 170-182
    • Friedland, W.1    Jacob, P.2    Paretzke, H.G.3    Stork, T.4
  • 103
    • 77953716710 scopus 로고    scopus 로고
    • Characteristics of DNA-binding proteins determine the biological sensitivity to high-linear energy transfer radiation
    • Wang,H., Zhang,X., Wang,P., Yu,X., Essers,J., Chen,D., Kanaar,R., Takeda,S. and Wang,Y. (2010) Characteristics of DNA-binding proteins determine the biological sensitivity to high-linear energy transfer radiation. Nucleic Acids Res., 38, 3245-3251.
    • (2010) Nucleic Acids Res. , vol.38 , pp. 3245-3251
    • Wang, H.1    Zhang, X.2    Wang, P.3    Yu, X.4    Essers, J.5    Chen, D.6    Kanaar, R.7    Takeda, S.8    Wang, Y.9
  • 104
    • 84873320525 scopus 로고    scopus 로고
    • Mechanisms of programmed DNA lesions and genomic instability in the immune system
    • Alt,F.W., Zhang,Y., Meng,F.-L., Guo,C. and Schwer,B. (2013) Mechanisms of programmed DNA lesions and genomic instability in the immune system. Cell, 152, 417-429.
    • (2013) Cell , vol.152 , pp. 417-429
    • Alt, F.W.1    Zhang, Y.2    Meng, F.-L.3    Guo, C.4    Schwer, B.5
  • 105
    • 84867386682 scopus 로고    scopus 로고
    • Chapter one - Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks
    • Frederick,W.A. (ed.) Academic Press, New york
    • Boboila,C., Alt,F.W. and Schwer,B. (2012) Chapter one - classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks. In: Frederick,W.A. (ed.), Advances in Immunology, Vol. 116. Academic Press, New york, pp. 1-49.
    • (2012) Advances in Immunology , vol.116 , pp. 1-49
    • Boboila, C.1    Alt, F.W.2    Schwer, B.3
  • 107
    • 0024371961 scopus 로고
    • A model relating cell survival to DNA fragment loss and unrepaired double-strand breaks
    • Ostashevsky,J.Y. (1989) A model relating cell survival to DNA fragment loss and unrepaired double-strand breaks. Radiat. Res., 118, 437-466.
    • (1989) Radiat. Res. , vol.118 , pp. 437-466
    • Ostashevsky, J.Y.1
  • 108
    • 0033867276 scopus 로고    scopus 로고
    • Higher-order structure of interphase chromosomes and radiation-induced chromosomal exchange aberrations
    • Ostashevsky,J.Y. (2000) Higher-order structure of interphase chromosomes and radiation-induced chromosomal exchange aberrations. Int. J. Radiat. Biol., 76, 1179-1187.
    • (2000) Int. J. Radiat. Biol. , vol.76 , pp. 1179-1187
    • Ostashevsky, J.Y.1
  • 110
    • 33646761276 scopus 로고    scopus 로고
    • Chromatin loops are responsible for higher counts of small DNA fragments induced by high-LET radiation, while chromosomal domains do not affect the fragment sizes
    • Ponomarev,A.L. and Cucinotta,F.A. (2006) Chromatin loops are responsible for higher counts of small DNA fragments induced by high-LET radiation, while chromosomal domains do not affect the fragment sizes. Int. J. Radiat. Biol., 82, 293-305.
    • (2006) Int. J. Radiat. Biol. , vol.82 , pp. 293-305
    • Ponomarev, A.L.1    Cucinotta, F.A.2
  • 111
    • 84868621848 scopus 로고    scopus 로고
    • Modeling cell survival after photon irradiation based on double-strand break clustering in megabase pair chromatin loops
    • Friedrich,T., Durante,M. and Scholz,M. (2012) Modeling cell survival after photon irradiation based on double-strand break clustering in megabase pair chromatin loops. Radiat. Res., 178, 385-394.
    • (2012) Radiat. Res. , vol.178 , pp. 385-394
    • Friedrich, T.1    Durante, M.2    Scholz, M.3
  • 112
    • 84855378613 scopus 로고    scopus 로고
    • Calculation of the biological effects of ion beams based on the microscopic spatial damage distribution pattern
    • Friedrich,T., Scholz,U., Elsässer,T., Durante,M. and Scholz,M. (2011) Calculation of the biological effects of ion beams based on the microscopic spatial damage distribution pattern. Int. J. Radiat. Biol., 88, 103-107.
    • (2011) Int. J. Radiat. Biol. , vol.88 , pp. 103-107
    • Friedrich, T.1    Scholz, U.2    Elsässer, T.3    Durante, M.4    Scholz, M.5
  • 113
    • 44849121667 scopus 로고    scopus 로고
    • Biophysical modeling of fragment length distributions of DNA plasmids after X and heavy-ion irradiation analyzed by atomic force microscopy
    • Elsässer,T., Brons,S., Psonka,K., Scholz,M., Gudowska- Nowak,E. and Taucher-Scholz,G. (2008) Biophysical modeling of fragment length distributions of DNA plasmids after X and heavy-ion irradiation analyzed by atomic force microscopy. Radiat. Res., 169, 649-659.
    • (2008) Radiat. Res. , vol.169 , pp. 649-659
    • Elsässer, T.1    Brons, S.2    Psonka, K.3    Scholz, M.4    Gudowska- Nowak, E.5    Taucher-Scholz, G.6
  • 114
    • 79956221990 scopus 로고    scopus 로고
    • Chromatin dynamics during cell cycle mediate conversion of DNA damage into chromatid breaks and affect formation of chromosomal aberrations: Biological and clinical significance
    • Terzoudi,G.I., Hatzi,V.I., Donta-Bakoyianni,C. and Pantelias,G.E. (2011) Chromatin dynamics during cell cycle mediate conversion of DNA damage into chromatid breaks and affect formation of chromosomal aberrations: biological and clinical significance. Mutat. Res., 711, 174-186.
    • (2011) Mutat. Res. , vol.711 , pp. 174-186
    • Terzoudi, G.I.1    Hatzi, V.I.2    Donta-Bakoyianni, C.3    Pantelias, G.E.4
  • 116
    • 58049192401 scopus 로고    scopus 로고
    • Mapping in vivo chromatin interactions in yeast suggests an extended chromatin fiber with regional variation in compaction
    • Dekker,J. (2008) Mapping in vivo chromatin interactions in yeast suggests an extended chromatin fiber with regional variation in compaction. J. Biol. Chem., 283, 34532-34540.
    • (2008) J. Biol. Chem. , vol.283 , pp. 34532-34540
    • Dekker, J.1
  • 117
    • 58149401194 scopus 로고    scopus 로고
    • Analysis of cryo-electron microscopy images does not support the existence of 30-nm chromatin fibers in mitotic chromosomes in situ
    • Eltsov,M., MacLellan,K.M., Maeshima,K., Frangakis,A.S. and Dubochet,J. (2008) Analysis of cryo-electron microscopy images does not support the existence of 30-nm chromatin fibers in mitotic chromosomes in situ. Proc. Natl Acad. Sci. USA, 105, 19732-19737.
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 19732-19737
    • Eltsov, M.1    Maclellan, K.M.2    Maeshima, K.3    Frangakis, A.S.4    Dubochet, J.5
  • 118
    • 84859421494 scopus 로고    scopus 로고
    • Human mitotic chromosomes consist predominantly of irregularly folded nucleosome fibres without a 30-nm chromatin structure
    • Nishino,Y., Eltsov,M., Joti,Y., Ito,K., Takata,H., Takahashi,Y., Hihara,S., Frangakis,A.S., Imamoto,N., Ishikawa,T. et al. (2012) Human mitotic chromosomes consist predominantly of irregularly folded nucleosome fibres without a 30-nm chromatin structure. EMBO J., 31, 1644-1653.
    • (2012) EMBO J. , vol.31 , pp. 1644-1653
    • Nishino, Y.1    Eltsov, M.2    Joti, Y.3    Ito, K.4    Takata, H.5    Takahashi, Y.6    Hihara, S.7    Frangakis, A.S.8    Imamoto, N.9    Ishikawa, T.10
  • 119
    • 35648930403 scopus 로고    scopus 로고
    • Chromatin fiber structure: Where is the problem now? Semin
    • van Holde,K. and Zlatanova,J. (2007) Chromatin fiber structure: where is the problem now? Semin. Cell Dev. Biol., 18, 651-658.
    • (2007) Cell Dev. Biol. , vol.18 , pp. 651-658
    • Van Holde, K.1    Zlatanova, J.2
  • 120
    • 73249137492 scopus 로고    scopus 로고
    • Determining spatial chromatin organization of large genomic regions using 5C technology
    • van Berkum,N.L. and Dekker,J. (2009) Determining spatial chromatin organization of large genomic regions using 5C technology. Methods Mol. Biol., 567, 189-213.
    • (2009) Methods Mol. Biol. , vol.567 , pp. 189-213
    • Van Berkum, N.L.1    Dekker, J.2
  • 125
    • 79956215808 scopus 로고    scopus 로고
    • Induction and repair of DNA double strand breaks: The increasing spectrum of nonhomologous end joining pathways
    • Mladenov,E. and Iliakis,G. (2011) Induction and repair of DNA double strand breaks: the increasing spectrum of nonhomologous end joining pathways. Mutat. Res., 711, 61-72.
    • (2011) Mutat. Res. , vol.711 , pp. 61-72
    • Mladenov, E.1    Iliakis, G.2
  • 126
    • 55249116558 scopus 로고    scopus 로고
    • G-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin
    • Kinner,A., Wu,W., Staudt,C. and Iliakis,G. (2008) g-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin. Nucleic Acids Res., 36, 5678-5694.
    • (2008) Nucleic Acids Res. , vol.36 , pp. 5678-5694
    • Kinner, A.1    Wu, W.2    Staudt, C.3    Iliakis, G.4
  • 127
    • 78149425175 scopus 로고    scopus 로고
    • Regulation of homologous recombination in eukaryotes
    • Heyer,W.-D., Ehmsen,K.T. and Liu,J. (2010) Regulation of homologous recombination in eukaryotes. Annu. Rev. Genet., 44, 113-139.
    • (2010) Annu. Rev. Genet. , vol.44 , pp. 113-139
    • Heyer, W.-D.1    Ehmsen, K.T.2    Liu, J.3
  • 128
    • 50649100744 scopus 로고    scopus 로고
    • Mechanism of eukaryotic homologous recombination
    • San Filippo,J., Sung,P. and Klein,H. (2008) Mechanism of eukaryotic homologous recombination. Annu. Rev. Biochem., 77, 229-257.
    • (2008) Annu. Rev. Biochem. , vol.77 , pp. 229-257
    • San Filippo, J.1    Sung, P.2    Klein, H.3
  • 129
    • 0035833552 scopus 로고    scopus 로고
    • Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
    • Walker,J.R., Corpina,R.A. and Goldberg,J. (2001) Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature, 412, 607-614.
    • (2001) Nature , vol.412 , pp. 607-614
    • Walker, J.R.1    Corpina, R.A.2    Goldberg, J.3
  • 130
    • 84865364870 scopus 로고    scopus 로고
    • Playing the end game: DNA double-strand break repair pathway choice
    • Chapman,J.R., Taylor,M.R.G. and Boulton,S.J. (2012) Playing the end game: DNA double-strand break repair pathway choice. Mol. Cell, 47, 497-510.
    • (2012) Mol. Cell , vol.47 , pp. 497-510
    • Chapman, J.R.1    Taylor, M.R.G.2    Boulton, S.J.3
  • 131
    • 77950862944 scopus 로고    scopus 로고
    • Double holliday junctions are intermediates of DNA break repair
    • Bzymek,M., Thayer,N.H., Oh,S.D., Kleckner,N. and Hunter,N. (2010) Double holliday junctions are intermediates of DNA break repair. Nature, 464, 937-941.
    • (2010) Nature , vol.464 , pp. 937-941
    • Bzymek, M.1    Thayer, N.H.2    Oh, S.D.3    Kleckner, N.4    Hunter, N.5
  • 132
    • 38049125555 scopus 로고    scopus 로고
    • The endless tale of nonhomologous end-joining
    • Weterings,E. and Chen,D.J. (2008) The endless tale of nonhomologous end-joining. Cell Res., 18, 114-124.
    • (2008) Cell Res. , vol.18 , pp. 114-124
    • Weterings, E.1    Chen, D.J.2
  • 133
    • 77950466186 scopus 로고    scopus 로고
    • NHEJ and its backup pathways in chromosomal translocations
    • Lieber,M.R. (2010) NHEJ and its backup pathways in chromosomal translocations. Nat. Struct. Mol. Biol., 17, 393-395.
    • (2010) Nat. Struct. Mol. Biol. , vol.17 , pp. 393-395
    • Lieber, M.R.1
  • 134
    • 79953032797 scopus 로고    scopus 로고
    • Mechanisms that promote and suppress chromosomal translocations in lymphocytes
    • Gostissa,M., Alt,F.W. and Chiarle,R. (2011) Mechanisms that promote and suppress chromosomal translocations in lymphocytes. Annu. Rev. Immunol., 29, 319-350.
    • (2011) Annu. Rev. Immunol. , vol.29 , pp. 319-350
    • Gostissa, M.1    Alt, F.W.2    Chiarle, R.3
  • 135
    • 34247601575 scopus 로고    scopus 로고
    • Non-homologous endjoining for repairing I-SceI-induced DNA double strand breaks in human cells
    • Honma,M., Sakuraba,M., Koizumi,T., Takashima,Y., Sakamoto,H. and Hayashi,M. (2007) Non-homologous endjoining for repairing I-SceI-induced DNA double strand breaks in human cells. DNA Repair, 6, 781-788.
    • (2007) DNA Repair , vol.6 , pp. 781-788
    • Honma, M.1    Sakuraba, M.2    Koizumi, T.3    Takashima, Y.4    Sakamoto, H.5    Hayashi, M.6
  • 136
    • 54849404458 scopus 로고    scopus 로고
    • MMEJ repair of double-strand breaks (director's cut): Deleted sequences and alternative endings
    • McVey,M. and Lee,S.E. (2008) MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings. Trends Genet., 24, 529-538.
    • (2008) Trends Genet. , vol.24 , pp. 529-538
    • McVey, M.1    Lee, S.E.2
  • 137
    • 33845657443 scopus 로고    scopus 로고
    • PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways
    • Wang,M., Wu,W., Wu,W., Rosidi,B., Zhang,L., Wang,H. and Iliakis,G. (2006) PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways. Nucleic Acids Res., 34, 6170-6182.
    • (2006) Nucleic Acids Res. , vol.34 , pp. 6170-6182
    • Wang, M.1    Wu, W.2    Wu, W.3    Rosidi, B.4    Zhang, L.5    Wang, H.6    Iliakis, G.7
  • 138
    • 79952368682 scopus 로고    scopus 로고
    • DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair
    • Gao,Y., Katyal,S., Lee,Y., Zhao,J., Rehg,J.E., Russell,H.R. and McKinnon,P.J. (2011) DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair. Nature, 471, 240-244.
    • (2011) Nature , vol.471 , pp. 240-244
    • Gao, Y.1    Katyal, S.2    Lee, Y.3    Zhao, J.4    Rehg, J.E.5    Russell, H.R.6    McKinnon, P.J.7
  • 142
    • 20144363082 scopus 로고    scopus 로고
    • DNA Ligase III as a candidate component of backup pathways of nonhomologous end joining
    • Wang,H., Rosidi,B., Perrault,R., Wang,M., Zhang,L., Windhofer,F. and Iliakis,G. (2005) DNA Ligase III as a candidate component of backup pathways of nonhomologous end joining. Cancer Res., 65, 4020-4030.
    • (2005) Cancer Res. , vol.65 , pp. 4020-4030
    • Wang, H.1    Rosidi, B.2    Perrault, R.3    Wang, M.4    Zhang, L.5    Windhofer, F.6    Iliakis, G.7
  • 145
    • 51649128895 scopus 로고    scopus 로고
    • Upregulation of WRN and DNA ligase IIIa in chronic myeloid leukemia: Consequences for the repair of DNA double-strand breaks
    • Sallmyr,A., Tomkinson,A.E. and Rassool,F.V. (2008) Upregulation of WRN and DNA ligase IIIa in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaks. Blood, 112, 1413-1423.
    • (2008) Blood , vol.112 , pp. 1413-1423
    • Sallmyr, A.1    Tomkinson, A.E.2    Rassool, F.V.3
  • 146
    • 41149176120 scopus 로고    scopus 로고
    • Histone H1 functions as a stimulatory factor in backup pathways of NHEJ
    • Rosidi,B., Wang,M., Wu,W., Sharma,A., Wang,H. and Iliakis,G. (2008) Histone H1 functions as a stimulatory factor in backup pathways of NHEJ. Nucleic Acids Res., 36, 1610-1623.
    • (2008) Nucleic Acids Res. , vol.36 , pp. 1610-1623
    • Rosidi, B.1    Wang, M.2    Wu, W.3    Sharma, A.4    Wang, H.5    Iliakis, G.6
  • 147
    • 84865647966 scopus 로고    scopus 로고
    • Inhibition of B-NHEJ in plateau-phase cells is not a direct consequence of suppressed growth factor signaling
    • Singh,S.K., Bednar,T., Zhang,L., Wu,W., Mladenov,E. and Iliakis,G. (2012) Inhibition of B-NHEJ in plateau-phase cells is not a direct consequence of suppressed growth factor signaling. Int. J. Radiat. Oncol. Biol. Phys., 84, e237-e243.
    • (2012) Int. J. Radiat. Oncol. Biol. Phys. , vol.84
    • Singh, S.K.1    Bednar, T.2    Zhang, L.3    Wu, W.4    Mladenov, E.5    Iliakis, G.6
  • 148
    • 69949173301 scopus 로고    scopus 로고
    • Backup pathways of NHEJ in cells of higher eukaryotes: Cell cycle dependence
    • Iliakis,G. (2009) Backup pathways of NHEJ in cells of higher eukaryotes: cell cycle dependence. Radiother. Oncol., 92, 310-315.
    • (2009) Radiother. Oncol. , vol.92 , pp. 310-315
    • Iliakis, G.1
  • 149
    • 37549006429 scopus 로고    scopus 로고
    • Repair of radiation induced DNA double strand breaks by backup NHEJ is enhanced in G2
    • Wu,W., Wang,M., Wu,W., Singh,S.K., Mussfeldt,T. and Iliakis,G. (2008) Repair of radiation induced DNA double strand breaks by backup NHEJ is enhanced in G2. DNA Repair, 7, 329-338.
    • (2008) DNA Repair , vol.7 , pp. 329-338
    • Wu, W.1    Wang, M.2    Wu, W.3    Singh, S.K.4    Mussfeldt, T.5    Iliakis, G.6
  • 150
    • 55249102702 scopus 로고    scopus 로고
    • Enhanced use of backup pathways of NHEJ in G2 in chinese hamster mutant cells with defects in the classical pathway of NHEJ
    • Wu,W., Wang,M., Mussfeldt,T. and Iliakis,G. (2008) Enhanced use of backup pathways of NHEJ in G2 in chinese hamster mutant cells with defects in the classical pathway of NHEJ. Radiat. Res., 170, 512-520.
    • (2008) Radiat. Res. , vol.170 , pp. 512-520
    • Wu, W.1    Wang, M.2    Mussfeldt, T.3    Iliakis, G.4
  • 151
    • 78650850519 scopus 로고    scopus 로고
    • Widespread dependence of backup NHEJ on growth state: Ramifications for the use of DNA-PK inhibitors
    • Singh,S.K., Wu,W., Zhang,L., Klammer,H., Wang,M. and Iliakis,G. (2011) Widespread dependence of backup NHEJ on growth state: ramifications for the use of DNA-PK inhibitors. Int. J. Radiat. Oncol. Biol. Phys., 79, 540-548.
    • (2011) Int. J. Radiat. Oncol. Biol. Phys. , vol.79 , pp. 540-548
    • Singh, S.K.1    Wu, W.2    Zhang, L.3    Klammer, H.4    Wang, M.5    Iliakis, G.6
  • 153
    • 37149027578 scopus 로고    scopus 로고
    • Processing of DNA damage clusters in human cells: Current status of knowledge
    • Georgakilas,A.G. (2008) Processing of DNA damage clusters in human cells: current status of knowledge. Mol. Biosyst., 4, 30-35.
    • (2008) Mol. Biosyst. , vol.4 , pp. 30-35
    • Georgakilas, A.G.1
  • 155
    • 84873440196 scopus 로고    scopus 로고
    • Pathway choice in DNA double strand break repair: Observations of a balancing act
    • Brandsma,I. and Gent,D.C. (2012) Pathway choice in DNA double strand break repair: observations of a balancing act. Genome Integrity, 3, 9.
    • (2012) Genome Integrity , vol.3 , pp. 9
    • Brandsma, I.1    Gent, D.C.2
  • 157
    • 38049155945 scopus 로고    scopus 로고
    • Regulation of DNA double-strand break repair pathway choice
    • Shrivastav,M., De Haro,L.P. and Nickoloff,J.A. (2008) Regulation of DNA double-strand break repair pathway choice. Cell Res., 18, 134-147.
    • (2008) Cell Res. , vol.18 , pp. 134-147
    • Shrivastav, M.1    De Haro, L.P.2    Nickoloff, J.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.