메뉴 건너뛰기




Volumn 40, Issue 1, 2012, Pages 173-178

DNA double-strand break repair within heterochromatic regions

Author keywords

Ataxia telangiectasia mutated signalling (ATM signalling); Chromatin structure; DNA double strand break repair; Heterochromatin; Homologous recombination; Ribosomal DNA (rDNA)

Indexed keywords

DNA BINDING PROTEIN;

EID: 84856287453     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20110631     Document Type: Review
Times cited : (28)

References (39)
  • 1
    • 0025739820 scopus 로고
    • Kinetics of DNA double-strand break repair throughout the cell cycle as assayed by pulsed field gel electrophoresis in CHO cells
    • Metzger, L. and Iliakis, G. (1991) Kinetics of DNA double-strand break repair throughout the cell cycle as assayed by pulsed field gel electrophoresis in CHO cells. Int. J. Radiat. Biol. 59, 1325-1339
    • (1991) Int. J. Radiat. Biol. , vol.59 , pp. 1325-1339
    • Metzger, L.1    Iliakis, G.2
  • 2
    • 77953166592 scopus 로고    scopus 로고
    • γ H2AX foci analysis for monitoring DNA double-strand break repair: Strengths, limitations and optimization
    • Lobrich, M., Shibata, A., Beucher, A., Fisher, A., Ensminger, M., Goodarzi, A.A., Barton, O. and Jeggo, P.A. (2010) γ H2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization. Cell Cycle 9, 662-669
    • (2010) Cell Cycle , vol.9 , pp. 662-669
    • Lobrich, M.1    Shibata, A.2    Beucher, A.3    Fisher, A.4    Ensminger, M.5    Goodarzi, A.A.6    Barton, O.7    Jeggo, P.A.8
  • 3
    • 0030750923 scopus 로고    scopus 로고
    • Hypersensitivity of ataxia telangiectasia fibroblasts to ionizing radiation is associated with a repair deficiency of DNA double-strand breaks
    • DOI 10.1080/095530097143266
    • Foray, N., Priestley, A., Alsbeih, G., Badie, C., Capulas, E.P., Arlett, C.F. and Malaise, E.P. (1997) Hypersensitivity of ataxia-telangiectasia fibroblasts to ionizing radiation is associated with a repair deficiency of DNA double-strand breaks. Int. J. Radiat. Biol. 72, 271-283 (Pubitemid 27390822)
    • (1997) International Journal of Radiation Biology , vol.72 , Issue.3 , pp. 271-283
    • Foray, N.1    Priestley, A.2    Alsbeih, G.3    Badie, C.4    Capulas, E.P.5    Arlett, C.F.6    Malaise, E.P.7
  • 4
    • 47349107760 scopus 로고    scopus 로고
    • ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin
    • DOI 10.1016/j.molcel.2008.05.017, PII S109727650800395X
    • Goodarzi, A.A., Noon, A.T., Deckbar, D., Ziv, Y., Shiloh, Y., Lobrich, M. and Jeggo, P.A. (2008) ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin. Mol. Cell 31, 167-177 (Pubitemid 352001394)
    • (2008) Molecular Cell , vol.31 , Issue.2 , pp. 167-177
    • Goodarzi, A.A.1    Noon, A.T.2    Deckbar, D.3    Ziv, Y.4    Shiloh, Y.5    Lobrich, M.6    Jeggo, P.A.7
  • 5
    • 80052512520 scopus 로고    scopus 로고
    • Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair
    • Woodbine, L., Brunton, H., Goodarzi, A.A., Shibata, A. and Jeggo, P.A. (2011) Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair. Nucleic Acids Res. 39, 6986-6997
    • (2011) Nucleic Acids Res. , vol.39 , pp. 6986-6997
    • Woodbine, L.1    Brunton, H.2    Goodarzi, A.A.3    Shibata, A.4    Jeggo, P.A.5
  • 7
    • 34447532525 scopus 로고    scopus 로고
    • Heterochromatin is refractory to γ-H2AX modification in yeast and mammals
    • DOI 10.1083/jcb.200612031
    • Kim, J.A., Kruhlak, M., Dotiwala, F., Nussenzweig, A. and Haber, J.E. (2007) Heterochromatin is refractory to γ -H2AX modification in yeast and mammals. J. Cell Biol. 178, 209-218 (Pubitemid 47076458)
    • (2007) Journal of Cell Biology , vol.178 , Issue.2 , pp. 209-218
    • Kim, J.-A.1    Kruhlak, M.2    Dotiwala, F.3    Nussenzweig, A.4    Haber, J.E.5
  • 8
    • 79961207835 scopus 로고    scopus 로고
    • DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin
    • Jakob, B., Splinter, J., Conrad, S., Voss, K.O., Zink, D., Durante, M., Lobrich, M. and Taucher-Scholz, G. (2011) DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin. Nucleic Acids Res. 39, 6489-6499
    • (2011) Nucleic Acids Res. , vol.39 , pp. 6489-6499
    • Jakob, B.1    Splinter, J.2    Conrad, S.3    Voss, K.O.4    Zink, D.5    Durante, M.6    Lobrich, M.7    Taucher-Scholz, G.8
  • 10
    • 75949122330 scopus 로고    scopus 로고
    • 53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair
    • Noon, A.T., Shibata, A., Rief, N., Lobrich, M., Stewart, G.S., Jeggo, P.A. and Goodarzi, A.A. (2010) 53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair. Nat. Cell Biol. 12, 177-184
    • (2010) Nat. Cell Biol. , vol.12 , pp. 177-184
    • Noon, A.T.1    Shibata, A.2    Rief, N.3    Lobrich, M.4    Stewart, G.S.5    Jeggo, P.A.6    Goodarzi, A.A.7
  • 11
    • 33746601439 scopus 로고    scopus 로고
    • Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM-and KAP-1 dependent pathway
    • DOI 10.1038/ncb1446, PII NCB1446
    • Ziv, Y., Bielopolski, D., Galanty, Y., Lukas, C., Taya, Y., Schultz, D.C., Lukas, J., Bekker-Jensen, S., Bartek, J. and Shiloh, Y. (2006) Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM and KAP-1 dependent pathway. Nat. Cell Biol. 8, 870-876 (Pubitemid 44151591)
    • (2006) Nature Cell Biology , vol.8 , Issue.8 , pp. 870-876
    • Ziv, Y.1    Bielopolski, D.2    Galanty, Y.3    Lukas, C.4    Taya, Y.5    Schultz, D.C.6    Lukas, J.7    Bekker-Jensen, S.8    Bartek, J.9    Shiloh, Y.10
  • 12
    • 76349099135 scopus 로고    scopus 로고
    • 53BP1 promotes ATM activity through direct interactions with the MRN complex
    • Lee, J.H., Goodarzi, A.A., Jeggo, P.A. and Paull, T.T. (2010) 53BP1 promotes ATM activity through direct interactions with the MRN complex. EMBO J. 29, 574-585
    • (2010) EMBO J. , vol.29 , pp. 574-585
    • Lee, J.H.1    Goodarzi, A.A.2    Jeggo, P.A.3    Paull, T.T.4
  • 13
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • DOI 10.1038/nature01368
    • Bakkenist, C.J. and Kastan, M.B. (2003) DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421, 499-506 (Pubitemid 36168436)
    • (2003) Nature , vol.421 , Issue.6922 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 14
    • 79955507697 scopus 로고    scopus 로고
    • HP1α recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair
    • Baldeyron, C., Soria, G., Roche, D., Cook, A.J. and Almouzni, G. (2011) HP1α recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair. J. Cell Biol. 193, 81-95
    • (2011) J. Cell Biol. , vol.193 , pp. 81-95
    • Baldeyron, C.1    Soria, G.2    Roche, D.3    Cook, A.J.4    Almouzni, G.5
  • 15
    • 79960055393 scopus 로고    scopus 로고
    • KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response
    • Goodarzi, A.A., Kurka, T. and Jeggo, P.A. (2011) KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response. Nat. Struct. Mol. Biol. 18, 831-839
    • (2011) Nat. Struct. Mol. Biol. , vol.18 , pp. 831-839
    • Goodarzi, A.A.1    Kurka, T.2    Jeggo, P.A.3
  • 17
    • 0035118229 scopus 로고    scopus 로고
    • Targeting histone deacetylase complexes via KRAB-zinc finger proteins: The PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2α subunit of NuRD
    • DOI 10.1101/gad.869501
    • Schultz, D.C., Friedman, J.R. and Rauscher, 3rd, F.J. (2001) Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2α subunit of NuRD. Genes Dev. 15, 428-443 (Pubitemid 32187004)
    • (2001) Genes and Development , vol.15 , Issue.4 , pp. 428-443
    • Schultz, D.C.1    Friedman, J.R.2    Rauscher III, F.J.3
  • 18
    • 77953819028 scopus 로고    scopus 로고
    • SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1
    • Li, X., Lin, H.H., Chen, H., Xu, X., Shih, H.M. and Ann, D.K. (2010) SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1. Sci. Signaling 3, ra32
    • (2010) Sci. Signaling , vol.3
    • Li, X.1    Lin, H.H.2    Chen, H.3    Xu, X.4    Shih, H.M.5    Ann, D.K.6
  • 20
    • 0037089626 scopus 로고    scopus 로고
    • SETDB1: A novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins
    • DOI 10.1101/gad.973302
    • Schultz, D.C., Ayyanathan, K., Negorev, D., Maul, G.G. and Rauscher, 3rd, F.J. (2002) SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. Genes Dev. 16, 919-932 (Pubitemid 34408542)
    • (2002) Genes and Development , vol.16 , Issue.8 , pp. 919-932
    • Schultz, D.C.1    Ayyanathan, K.2    Negorev, D.3    Maul, G.G.4    Rauscher III, F.J.5
  • 22
    • 79960812015 scopus 로고    scopus 로고
    • Understanding the limitations of radiation-induced cell cycle checkpoints
    • Deckbar, D., Jeggo, P.A. and Lobrich, M. (2011) Understanding the limitations of radiation-induced cell cycle checkpoints. Crit. Rev. Biochem. Mol. Biol. 46, 271-283
    • (2011) Crit. Rev. Biochem. Mol. Biol. , vol.46 , pp. 271-283
    • Deckbar, D.1    Jeggo, P.A.2    Lobrich, M.3
  • 23
    • 79952314830 scopus 로고    scopus 로고
    • Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair
    • Chiolo, I., Minoda, A., Colmenares, S.U., Polyzos, A., Costes, S.V. and Karpen, G.H. (2011) Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair. Cell 144, 732-744
    • (2011) Cell , vol.144 , pp. 732-744
    • Chiolo, I.1    Minoda, A.2    Colmenares, S.U.3    Polyzos, A.4    Costes, S.V.5    Karpen, G.H.6
  • 25
    • 55849109584 scopus 로고    scopus 로고
    • The epigenetics of rRNA genes: From molecular to chromosome biology
    • McStay, B. and Grummt, I. (2008) The epigenetics of rRNA genes: from molecular to chromosome biology. Annu. Rev. Cell Dev. Biol. 24, 131-157
    • (2008) Annu. Rev. Cell Dev. Biol. , vol.24 , pp. 131-157
    • McStay, B.1    Grummt, I.2
  • 26
    • 52049125947 scopus 로고    scopus 로고
    • Replication fork arrest, recombination and the maintenance of ribosomal DNA stability
    • Tsang, E. and Carr, A.M. (2008) Replication fork arrest, recombination and the maintenance of ribosomal DNA stability. DNA Repair 7, 1613-1623
    • (2008) DNA Repair , vol.7 , pp. 1613-1623
    • Tsang, E.1    Carr, A.M.2
  • 28
  • 29
    • 33750437743 scopus 로고    scopus 로고
    • Ubc9- and Mms21-Mediated Sumoylation Counteracts Recombinogenic Events at Damaged Replication Forks
    • DOI 10.1016/j.cell.2006.08.050, PII S0092867406012785
    • Branzei, D., Sollier, J., Liberi, G., Zhao, X., Maeda, D., Seki, M., Enomoto, T., Ohta, K. and Foiani, M. (2006) Ubc9- and mms21-mediated sumoylation counteracts recombinogenic events at damaged replication forks. Cell 127, 509-522 (Pubitemid 44647424)
    • (2006) Cell , vol.127 , Issue.3 , pp. 509-522
    • Branzei, D.1    Sollier, J.2    Liberi, G.3    Zhao, X.4    Maeda, D.5    Seki, M.6    Enomoto, T.7    Ohta, K.8    Foiani, M.9
  • 30
    • 65249118311 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae Esc2 and Smc5-6 proteins promote sister chromatid junction-mediated intra-S repair
    • Sollier, J., Driscoll, R., Castellucci, F., Foiani, M., Jackson, S.P. and Branzei, D. (2009) The Saccharomyces cerevisiae Esc2 and Smc5-6 proteins promote sister chromatid junction-mediated intra-S repair. Mol. Biol. Cell 20, 1671-1682
    • (2009) Mol. Biol. Cell , vol.20 , pp. 1671-1682
    • Sollier, J.1    Driscoll, R.2    Castellucci, F.3    Foiani, M.4    Jackson, S.P.5    Branzei, D.6
  • 31
    • 58749101522 scopus 로고    scopus 로고
    • Smc5/6 maintains stalled replication forks in a recombination-competent conformation
    • Irmisch, A., Ampatzidou, E., Mizuno, K., O'Connell, M.J. and Murray, J.M. (2009) Smc5/6 maintains stalled replication forks in a recombination-competent conformation. EMBO J. 28, 144-155
    • (2009) EMBO J. , vol.28 , pp. 144-155
    • Irmisch, A.1    Ampatzidou, E.2    Mizuno, K.3    O'Connell, M.J.4    Murray, J.M.5
  • 32
    • 68249153738 scopus 로고    scopus 로고
    • Silent chromatin at the middle and ends: Lessons from yeasts
    • Buhler, M. and Gasser, S.M. (2009) Silent chromatin at the middle and ends: lessons from yeasts. EMBO J. 28, 2149-2161
    • (2009) EMBO J. , vol.28 , pp. 2149-2161
    • Buhler, M.1    Gasser, S.M.2
  • 33
    • 77951219621 scopus 로고    scopus 로고
    • A proteome-wide analysis of kinase-substrate network in the DNA damage response
    • Chen, S.H., Albuquerque, C.P., Liang, J., Suhandynata, R.T. and Zhou, H. (2010) A proteome-wide analysis of kinase-substrate network in the DNA damage response. J. Biol. Chem. 285, 12803-12812
    • (2010) J. Biol. Chem. , vol.285 , pp. 12803-12812
    • Chen, S.H.1    Albuquerque, C.P.2    Liang, J.3    Suhandynata, R.T.4    Zhou, H.5
  • 35
    • 37249031844 scopus 로고    scopus 로고
    • Msc1 acts through histone H2A.Z to promote chromosome stability in Schizosaccharomyces pombe
    • DOI 10.1534/genetics.107.078691
    • Ahmed, S., Dul, B., Qiu, X. and Walworth, N.C. (2007) Msc1 acts through histone H2A.Z to promote chromosome stability in Schizosaccharomyces pombe. Genetics. 177, 1487-1497 (Pubitemid 350277047)
    • (2007) Genetics , vol.177 , Issue.3 , pp. 1487-1497
    • Ahmed, S.1    Dul, B.2    Qiu, X.3    Walworth, N.C.4
  • 36
    • 6344254386 scopus 로고    scopus 로고
    • Role of the fission yeast SUMO E3 ligase Pli1p in centromere and telomere maintenance
    • DOI 10.1038/sj.emboj.7600394
    • Xhemalce, B., Seeler, J.S., Thon, G., Dejean, A. and Arcangioli, B. (2004) Role of the fission yeast SUMO E3 ligase Pli1p in centromere and telomere maintenance. EMBO J. 23, 3844-3853 (Pubitemid 39389715)
    • (2004) EMBO Journal , vol.23 , Issue.19 , pp. 3844-3853
    • Xhemalce, B.1    Seeler, J.-S.2    Thon, G.3    Dejean, A.4    Arcangioli, B.5
  • 37
    • 43849092514 scopus 로고    scopus 로고
    • Rad52 sumoylation and its involvement in the efficient induction of homologous recombination
    • Ohuchi, T., Seki, M., Branzei, D., Maeda, D., Ui, A., Ogiwara, H., Tada, S. and Enomoto, T. (2008) Rad52 sumoylation and its involvement in the efficient induction of homologous recombination. DNA Repair 7, 879-889
    • (2008) DNA Repair , vol.7 , pp. 879-889
    • Ohuchi, T.1    Seki, M.2    Branzei, D.3    Maeda, D.4    Ui, A.5    Ogiwara, H.6    Tada, S.7    Enomoto, T.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.