Interplay of two major repair pathways in the processing of complex double-strand DNA breaks

DNA Repair

Volumn 7, Issue 8, 2008, Pages 1372-1383

  Dobbs, Tracey A ^a   Palmer, Philip ^a   Maniou, Zoitsa ^a   Lomax, Martine E ^a   O'Neill, Peter ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Base excision repair; Clustered DNA damage; Double strand breaks; Ligation; Oxidised guanine

Indexed keywords

8 HYDROXYGUANINE; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; OLIGONUCLEOTIDE;

APURINIC SITE; ARTICLE; CONTROLLED STUDY; DNA STRAND BREAKAGE; EXCISION REPAIR; HELA CELL; HUMAN; HUMAN CELL; IONIZING RADIATION; PLASMID; PRIORITY JOURNAL;

BASE SEQUENCE; DEOXYGUANOSINE; DNA DAMAGE; DNA GLYCOSYLASES; DNA PRIMERS; DNA REPAIR; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; HUMANS; PLASMIDS;

EID: 46649102827     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2008.05.001     Document Type: Article

References (45)

1. von Sonntag C. Free-Radical-Induced DNA Damage and its Repair (2006), Springer-Verlag, Heidelberg
2. Regulus P., Duroux B., Bayle P.A., Favier A., Cadet J., and Ravanat J.L. Oxidation of the sugar moiety of DNA by ionizing radiation or bleomycin could induce the formation of a cluster DNA lesion. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 14032-14037
3. O'Neill P., and Fielden E.M. Primary free radical processes in DNA. In: Lett J.T., and Sinclair W.K. (Eds). Adv. Radiat. Biol. 17 (1993) 53-120
4. Curtis S.B. Lethal and potentially lethal lesions induced by radiation-a unified repair model. Radiat. Res. 106 (1986) 252-270
5. Olive P.L. The role of DNA single- and double-strand breaks in cell killing by ionizing radiation. Radiat. Res. 150 5 Suppl. (1998) S42-S51
6. Badie C., Iliakis G., Foray N., Alsbeih G., Cedervall B., Chavaudra N., Pantelias G., Arlett C., and Malaise E.P. Induction and rejoining of DNA double-strand breaks and interphase chromosome breaks after exposure to X rays in one normal and two hypersensitive human fibroblast cell lines. Radiat. Res. 144 (1995) 26-35
7. Hanai R., Yazu M., and Heida K. On the experimental distinction between ssbs and dsbs in circular DNA. Int. J. Radiat. Biol. 73 (1998) 475-479
8. O'Neill P. Radiation-induced damage in DNA. In: Jonah C.D., and Rao B.S.M. (Eds). Radiation Chemistry: Present Status and Future Trends (2001), Elsevier
9. Ward J.F. The complexity of DNA damage: relevance to biological consequences. Int. J. Radiat. Biol. 66 (1994) 427-432
10. Goodhead D.T. Initial events in the cellular effects of ionizing radiations: clustered damage in DNA. Int. J. Radiat. Biol. 65 (1994) 7-17
11. Nikjoo H., O'Neill P., Wilson W.E., and Goodhead D.T. Computational approach for determining the spectrum of DNA damage induced by ionizing radiation. Radiat. Res. 156 (2001) 577-583
12. Datta K., Neumann R.D., and Winters T.A. Characterization of complex apurinic/apyrimidinic-site clustering associated with an authentic site-specific radiation-induced DNA double-strand breaks. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 10569-10574
13. Datta K., Jaruga P., Dizdaroglu M., Neumann R.D., and Winters T.A. Molecular analysis of base damage clustering associated with a site-specific radiation-induced DNA double-strand breaks. Radiat. Res. 166 (2006) 767-781
14. 125I decay-induced double-strand break end-group structures. Radiat. Res. 167 (2007) 152-166
15. Jenner T.J., deLara C.M., O'Neill P., and Stevens D.L. Induction and rejoining of DNA double-strand breaks in V79-4 mammalian cells following gamma- and alpha-irradiation. Int. J. Radiat. Biol. 64 (1993) 265-273
16. Leatherbarrow E.L., Harper J.V., Cucinotta F.A., and O'Neill P. Induction and quantification of gamma-H2AX foci following low and high LET-irradiation. Int. J. Radiat. Biol. 82 (2006) 111-118
17. Pinto M., Prise K.M., and Michael B.D. Evidence for complexity at the nanometer scale of radiation-induced DNA DSBs as a determinant of rejoining kinetics. Radiat. Res. 164 (2005) 73-85
18. Jeggo P.A. The fidelity of repair of radiation damage. Radiat. Prot. Dosimetry 99 (2002) 117-122
19. Riballo E., Kühne M., Rief N., Doherty A., Smith G.C.M., Recio M.-J., Reis C., Dahm K., Fricke A., Krempler A., et al. A pathway of double-strand break rejoining dependent upon ATM, Artemis and proteins locating to γ-H2AX foci. Mol. Cell 16 (2004) 715-724
20. Kühne M., Riballo E., Rief N., Rothkamm K., Jeggo P.A., and Löbrich M. A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity. Cancer Res. 64 (2004) 500-508
21. Löbrich M., and Jeggo P.A. Harmonising the response to DSBs: a new string to the ATM bow. DNA Repair 4 (2005) 749-759
22. Featherstone C., and Jackson S.P. DNA double-strand break repair. Curr. Biol. 90 (1999) 759-761
23. Dai Y., Kysela B., Hanakahi L.A., Manolis K., Riballo E., Stumm M., Harville T.O., West S.C., Oettinger M.A., and Jeggo P.A. Non-homologous end joining and V(D)J recombination require an additional factor. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 2462-2467
24. Lees-Miller S.P., and Meek K. Repair of DNA double-strand breaks by non-homologous end joining. Biochimie 85 (2003) 1161-1173
25. Rothkamm K., Kuhne M., Jeggo P.A., and Löbrich M. Radiation-induced genomic rearrangements formed by nonhomologous end-joining of DNA double-strand breaks. Cancer Res. 61 (2001) 3886-3893
26. Henner W.D., Grunberg S.M., and Haseltine W.A. Sites and structure of gamma radiation-induced DNA strand breaks. J. Biol. Chem. 257 (1982) 11750-11754
27. Henner W.D., Rodriguez L.O., Hecht S.M., and Haseltine W.A. Gamma ray induced deoxyribonucleic acid strand breaks. J. Biol. Chem. 258 (1983) 173-711
28. Chappell C., Hanakahi L.A., Karimi-Busheri F., Weinfeld M., and West S.C. Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining. EMBO J. 21 (2002) 2827-2832
29. Povirk L.F., Zhou T., Zhou R., Cowan M.J., and Yannone S.M. Processing of 3′-phosphoglycolate-terminated DNA double strand breaks by Artemis nuclease. J. Biol. Chem. 282 (2007) 3547-3558
30. Dianov G.L., and Parsons J.L. Co-ordination of single strand break repair. DNA Repair 6 (2007) 454-460
31. Douki T., Ravanat J.-L., Pouget J.-P., Testard I., and Cadet J. Minor contribution of direct ionization to DNA base damage induced by heavy ions. Int. J. Radiat. Biol. 82 (2006) 119-127
32. Cadet J., Bellon S., Douki T., Frelon S., Gasparutto D., Muller E., Pouget J.-P., Ravanat J.L., Romieu A., and Sauvaigo S. Radiation-induced DNA damage: formation, measurement, and biochemical features. J. Environ. Pathol. Toxicol. Oncol. 23 (2004) 33-43
33. Manley J.L., Fire A., Samuels M., and Sharp P.A. In vitro transcription: whole-cell extract. Methods Enzymol. 101 (1983) 568-582
34. Hazra T.K., Izumi T., Boldogh I., Imhoff B., Kow Y.W., Jaruga P., Dizdaroglu M., and Mitra S. Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 3523-3528
35. Wiederhold L., Leppard J.B., Kedar P., Karimi-Busheri F., Rasouli-Nia A., Weinfeld M., Tomkinson A.E., Izumi T., Prasad R., Wilson S.H., Mitra S., and Hazra T.K. AP endonuclease-independent DNA base excision repair in human cells. Mol. Cell 15 (2004) 209-220
36. Tchou J., Michaels M.L., Miller J.H., and Grollman A.P. Function of the zinc finger in Escherichia coli Fpg protein. J. Biol. Chem. 268 (1993) 26738-26744
37. Castaing B., Fourrey J.L., Hervouet N., Thomas M., Boiteux S., and Zelwer C. AP site structural determinants for Fpg specific recognition. Nucleic Acids Res. 27 (1999) 608-615
38. David-Cordonnier M.H., Laval J., and O'Neill P. Recognition and kinetics for excision of a base lesion within clustered DNA damage by the Escherichia coli proteins Fpg and Nth. Biochemistry 40 (2001) 5738-5746
39. David-Cordonnier M.H., Laval J., and O'Neill P. Efficiency of excision of 8-oxo-guanine within DNA clustered damage by XRS5 nuclear extracts and purified human OGG1 protein. Biochemistry 40 (2001) 11811-11818
40. Parsons J.L., Zharkov D.O., and Dianov G.L. NEIL1 excises 3′ end proximal oxidative DNA lesions resistant to cleavage by NTH1 and OGG1. Nucleic Acids Res. 33 (2005) 4849-4856
41. Rosenquist T.A., Zaika E., Fernandes A.S., Zharkov D.O., Miller H., and Grollman A.P. The novel DNA glycosylase, NEIL1, protects mammalian cells from radiation-mediated cell death. DNA Repair 2 (2003) 581-591
42. Ng P.S., and Bergstrom D.E. Protein-DNA footprinting by endcapped duplex oligodeoxyribonucleotides. Nucleic Acids Res. 32 (2004) e107
43. Parsons J.L., Dianova I.I., and Dianov G.L. APE1 is the major 3′-phosphoglycolate activity in human cell extracts. Nucleic Acids Res. 32 (2005) 3531-3536
44. Dobson C.J., and Allinson S.L. The phosphatase activity of mammalian polynucleotide kinase takes precedence over its kinase activity in repair of single strand breaks. Nucleic Acids Res. 34 (2006) 2230-2237
45. Raymond A.C., Staker B.L., and Burgin Jr. A.B. Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1). J. Biol. Chem. 280 (2005) 22029-22035