Base excision repair processing of abasic site/single-strand break lesions within clustered damage sites associated with XRCC1 deficiency

Nucleic Acids Research

Volumn 35, Issue 22, 2007, Pages 7676-7687

  Mourgues, Sophie ^a   Lomax, Martine E ^a   O'Neill, Peter ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYGUANINE; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; LIGASE; LIGASE I; LIGASE III; OLIGONUCLEOTIDE; SCAFFOLD PROTEIN; SINGLE STRANDED DNA; UNCLASSIFIED DRUG; XRCC1 PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA STRAND; DNA STRAND BREAKAGE; DNA STRUCTURE; ENZYME ACTIVITY; EXCISION REPAIR; HAMSTER; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN FUNCTION;

ANIMALS; CELL EXTRACTS; CELL LINE; CELL NUCLEUS; CRICETINAE; CRICETULUS; DNA BREAKS, SINGLE-STRANDED; DNA DAMAGE; DNA LIGASES; DNA POLYMERASE BETA; DNA REPAIR; DNA-BINDING PROTEINS; FLAP ENDONUCLEASES; GUANOSINE; MUTATION;

CRICETINAE;

EID: 38049055871     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkm947     Document Type: Article

References (44)

1. Ward,J.F. (1985) Biochemistry of DNA lesions. Radiat. Res. Suppl., 8, S103-S111.
2. Goodhead,D.T. (1994) Initial events in the cellular effects of ionizing radiations: Clustered damage in DNA. Int. J. Radiat. Biol., 65 7-17.
3. Gulston,M., Fulford,J., Jenner,T., de Lara,C. and O'Neill,P. (2002) Clustered DNA damage induced by gamma radiation in human fibroblasts (HF19), hamster (V79-4) cells and plasmid DNA is revealed as Fpg and Nth sensitive sites. Nucleic Acids Res., 30, 3464-3472.
4. Sutherland,B.M., Bennett,P.V., Sidorkina,O. and Laval,J. (2000) Clustered DNA damages induced in isolated DNA and in human cells by low doses of ionizing radiation. Proc. Natl Acad. Sci. USA, 97, 103-108.
5. Jenner,T.J., Fulford,J. and O'Neill,P. (2001) Contribution of base lesions to radiation-induced clustered DNA damage: Implication for models of radiation response. Radiat. Res., 156, 590-593.
6. Sutherland,B.M., Bennett,P.V., Sutherland,J.C. and Laval,J. (2002) Clustered DNA damages induced by x rays in human cells. Radiat. Res. 157, 611-616.
7. Gulston,M., de Lara,C., Jenner,T., Davis,E. and O'Neill,P. (2004) Processing of clustered DNA damage generates additional double-strand breaks in mammalian cells post-irradiation. Nucleic Acids Res., 32, 1602-1609.
8. D'Souza,D.I. and Harrison,L. (2003) Repair of clustered uracil DNA damages in Escherichia coli. Nucleic Acids Res., 31, 4573-4581.
9. Malyarchuk,S., Youngblood,R., Landry,A.M., Quiflin,E. and Harrison,L. (2003) The mutation frequency of 8-oxo-7,8-dihydroguanine (8-oxodG) situated in a multiply damaged site: Comparison of a single and two closely opposed 8-oxodG in Escherichia coli. DNA Repair, 2, 695-705.
10. Malyarchuk,S., Brame,K.L.; Youngblood,R., Shi,R. and Harrison,L. (2004). Two clustered 8-oxo-7,8-dihydroguanine (8-oxodG) lesions increase the point mutation frequency of 8-oxodG, but do not result in double strand breaks or deletions in Escherichia coli. Nucleic Acids Res., 32 5721-5731.
11. Shikazono,N., Pearson,C., ONeill,P. and Thacker,J. (2006) The roles of specific glycosylases in determining the mutagenic consequences of clustered DNA base damage. Nucleic Acids Res., 34, 3722-3730.
12. Harrison,L., Brame,K.L., Geltz,L.E. and Landry,A.M. (2006) Closely opposed apurinic/apyrimidinic sites are converted to double strand breaks in Escherichia coli even in the absence of exonuclease III, endonuclease IV, nucleotide excision repair and AP lyase cleavage. DNA Repair, 5, 324-335.
13. Pearson,C.G., Shikazono,N., Thacker,J. and O'Neill,P. (2004) Enhanced mutagenic potential of 8-oxo-7 8-dihydroguanine when present within a clustered DNA damage site. Nuclei Acids Res., 32, 263-270.
14. Dianov,G.L. and Parsons,J.L. (2007) Co-ordination of DNA single strand break repair. DNA Repair, 6, 454-460.
15. Dianov,G.L., Sleeth,K.M., Dianova,I.I. and Allinson,S.L. (2003) Repair of abasic sites in DNA. Mutat. Res., 531, 157-103.
16. Weinfeld,M., Rasouli-Nia,A., Chaudhry,M.A. and Britten,R.A. (2001) Response of base excision repair enzymes to complex DNA lesions. Radiat. Res., 156, 584-589.
17. Lomax,M.E., Gulston,M.K. and O'Neill,P. (2002) Chemical aspects of clustered DNA damage induction by ionising radiation. Radiat. Prot. Dosimetry, 99, 63-68.
18. Wallace,S. S. (2002) Biological consequences of free radical-damaged DNA bases. Free Radic. Biol. Med., 33, 1-14.
19. Chaudhry,M.A. and Weinfeld,M. (1995) The action of Escherichia coli endonuclease III on multiply damaged sites in DNA. J. Mol. Biol., 249, 914-922.
20. David-Cordonnier,M.H., Boiteux,S. and O'Neill,P. (2001) Efficiency of excision of 8-oxo-guanine within DNA clustered damage by XRS5 nuclear extracts and purified human OGG1 protein. Biochemistry, 40, 11811-11818.
21. David-Cordonnier,M.H., Cunniffe,S.M., Hickson,I.D. and O'Neill,P. (2002) Efficiency of incision of an AP site within clustered DNA damage by the major human AP endonuclease. Biochemistry, 41, 634-642.
22. Lomax,M.E., Cunniffe,S. and O'Neill,P. (2004) 8-OxoG retards the activity of the ligase III/XRCC1 complex during the repair of a single-strand break, when present within a clustered DNA damage site. DNA Repair, 3, 289-299.
23. Chaudhry,M.A. and Weinfeld,M. (1997) Reactivity of human apurinic/ apyrimidinic endonuclease and Escherichia coli exonuclease III with bistranded abasic sites in DNA. J. Biol. Chem., 272, 15650-15655.
24. Harrison,L., Hatahet,Z. and Wallace,S.S. (1999) In vitro repair of synthetic ionizing radiation-induced multiply damaged DNA sites. J. Mol. Biol., 290, 667-684.
25. Eot-Houllier,G., Gonera,M., Gasparutto,D., Giustranti,C. and Sage,E. (2007) Interplay between DNA N-glycosylases/AP lyases at multiply damaged sites and biological consequences. Nucleic Acids Res., 35, 3355-3366.
26. Lomax,M.E., Cunniffe,S. and O'Neill,P. (2004) Efficiency of repair of an abasic site within DNA clustered damage sites by mammalian cell nuclear extracts. Biochemistry, 43, 11017-11026.
27. Vidal,A.E., Boiteux,S., Hickson,I.D. and Radicella,J.P. (2001) XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactions. EMBO J., 20, 6530-6539.
28. Caldecott,K.W., Aoufouchi,S., Johnson,P. and Shall,S. (1996) XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular 'nick-sensor' in vitro. Nucleic Acids Res., 24, 4387-4394.
29. Kubota,Y., Nash,R.A., Klungland,A., Schar,P., Barnes,D.E. and Lindahl,T. (1996) Reconstitution of DNA base excision-repair with purified human proteins: Interaction between DNA polymerase beta-and the XRCC1 protein. EMBO J., 15, 6662-6670.
30. Caldecott,K.W., McKeown,C.K., Tucker,J.D., Ljungquist,S. and Thompson,L.H. (1994) An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III. Mol. Cell. Biol., 14, 68-76.
31. Fan,J., Otterlei,M., Wong,H.K., Tomkinson,A.E. and Wilson,D.M.III (2004) XRCC1 co-localizes and physically interacts with PCNA. Nucleic Acids Res., 32, 2193-2201.
32. Masson,M., Niedergang,C., Schreiber,V., Muller,S., Menissier-de Murcia,J. and de Murcia,G. (1998) XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage. Mol. Cell. Biol., 18, 3563-3571.
33. Marsin,S., Vidal,A.E., Sossou,M., Menissier-de Murcia,J., Le Page,F., Boiteux,S., de Murcia,G. and Radicella,J.P. (2003) Role of XRCC1 in the coordination and stimulation of oxidative DNA damage repair initiated by the DNA glycosylase hOGG1. J. Biol. Chem., 279, 44068-44074.
34. Caldecott,K.W. (2003) XRCC1 and DNA strand break repair. DNA Repair 2, 955-969.
35. Beernink,P.T., Hwang,M., Ramirez,M., Murphy,M.B., Doyle,S.A. and Thelen,M.P. (2005) Specificity of protein interactions mediated by BRCT domains of the XRCC1 DNA repair protein. J. Biol. Chem., 280 30206-30213.
36. Sleeth,K.M., Robson,R.L. and Dianov,G.L. (2004) Exchangeability of mammalian DNA ligases between base excision repair pathways. Biochemistry, 43, 12924-12930.
37. David-Cordonnier,M.H., Boiteux, S. and O'Neill,P. (2001) Excision of 8-oxoguanine within clustered damage by the yeast OGG1 protein. Nucleic Acids Res., 29, 1107-1113.
38. Thompson,L.H., Brookman,K.W., Jones,N.J., Allen,S.A. and Carrano,A.V. (1990) Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange. Mol. Cell. Biol., 10, 6160-6171.
39. Matsumoto,Y. and Kim,K. (1995) Excision of deoxyribose phosphate residues by DNA polymerase beta during DNA repair. Science, 269 699-702.
40. Satoh,M. S. and Lindahl,T. (1992) Role of poly(ADP-ribose) formation in DNA repair. Nature, 356, 356-358.
41. Hodgkins,P.S., Fairman,M.P. and O'Neill,P. (1996) Rejoining of gamma-radiation-induced single-strand breaks in plasmid DNA by human cell extracts dependence on the concentration of the hydroxyl radical scavenger, Tris. Radiat. Res., 145, 24-30.
42. Nazarkina,Z.K., Khodyreva,S.N., Marsin,S., Lavrik,O.I. and Radicella,J.P. (2007) XRCC1 interactions with base excision repair DNA intermediates. DNA Repair, 6, 254-264.
43. Fujimoto,H., Pinak,M., Nemoto,T., O'Neill,P., Kume,E., Saito,K. and Maekawa,H. (2005) Molecular dynamics simulation of clustered DNA damage sites containing 8-oxoguanine and abasic site. J. Comput. Chem., 26, 788-798.
44. Tomkinson,A.E., Vijayakumar,S., Pascal,J.M. and Ellenberger,T. (2006) DNA ligases: Structure, reaction mechanism, and function. Chem. Rev. 106, 687-699.