-
1
-
-
0028816847
-
Purification and characterization of hypoxia-inducible factor 1
-
Wang GL, Semenza GL. 1995. Purification and characterization of hypoxia-inducible factor 1. J. Biol. Chem. 270:1230-377
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 1230-1377
-
-
Wang, G.L.1
Semenza, G.L.2
-
2
-
-
0029051439
-
Hypoxia-inducible factor 1 is a basic-helix-loophelix-PAS heterodimer regulated by cellular O2 tension
-
Wang GL, Jiang BH, Rue EA, Semenza GL. 1995. Hypoxia-inducible factor 1 is a basic-helix-loophelix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl. Acad. Sci. USA 92:5510-144
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 5510-5154
-
-
Wang, G.L.1
Jiang, B.H.2
Rue, E.A.3
Semenza, G.L.4
-
3
-
-
15444342958
-
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1?
-
Iyer NV, Kotch LE, Agani F, Leung SW, Laughner E, et al. 1998. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1?. Genes Dev. 12:149-622
-
(1998)
Genes Dev.
, vol.12
, pp. 149-622
-
-
Iyer, N.V.1
Kotch, L.E.2
Agani, F.3
Leung, S.W.4
Laughner, E.5
-
4
-
-
0345490692
-
Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1?
-
Compernolle V, Brusselmans K, Franco D, Moorman A, Dewerchin M, et al. 2003. Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1?. Cardiovasc. Res. 60:569-799
-
(2003)
Cardiovasc. Res.
, vol.60
, pp. 569-799
-
-
Compernolle, V.1
Brusselmans, K.2
Franco, D.3
Moorman, A.4
Dewerchin, M.5
-
5
-
-
33748742457
-
Hypoxia-inducible factor 1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development
-
Yoon D, Pastore YD, Divoky V, Liu E,Mlodnicka AE, et al. 2006. Hypoxia-inducible factor 1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development. J. Biol. Chem. 281:25703-111
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 25703-25121
-
-
Yoon, D.1
Pastore, Y.D.2
Divoky, V.3
Liu Emlodnicka, A.E.4
-
6
-
-
84865556443
-
Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development
-
Lage K, Greenway SC, Rosenfeld JA, Wakimoto H, Gorham JM, et al. 2012. Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development. Proc. Natl. Acad. Sci. USA 109:14035-400
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 14035-14400
-
-
Lage, K.1
Greenway, S.C.2
Rosenfeld, J.A.3
Wakimoto, H.4
Gorham, J.M.5
-
8
-
-
0033435198
-
Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain
-
Bergeron M, Yu AY, Solway KE, Semenza GL, Sharp FR. 1999. Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain. Eur. J. Neurosci. 11:4159-700
-
(1999)
Eur. J. Neurosci.
, vol.11
, pp. 4159-4700
-
-
Bergeron, M.1
Yu, A.Y.2
Solway, K.E.3
Semenza, G.L.4
Sharp, F.R.5
-
9
-
-
0031957221
-
Cardiac hypertrophy in chronically anemic fetal sheep: Increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1
-
Martin C, Yu AY, Jiang BH, Davis L, Kimberly D, et al. 1998. Cardiac hypertrophy in chronically anemic fetal sheep: Increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1. Am. J. Obstet. Gynecol. 178:527-344
-
(1998)
Am. J. Obstet. Gynecol.
, vol.178
, pp. 527-344
-
-
Martin, C.1
Yu, A.Y.2
Jiang, B.H.3
Davis, L.4
Kimberly, D.5
-
10
-
-
0034594876
-
Early expression of angiogenesis factors in acute myocardial ischemia and infarction
-
Lee SH, Wolf PL, Escudero R, Deutsch R, Jamieson SW, et al. 2000. Early expression of angiogenesis factors in acute myocardial ischemia and infarction. N. Engl. J. Med. 342:626-333
-
(2000)
N. Engl. J. Med.
, vol.342
, pp. 626-333
-
-
Lee, S.H.1
Wolf, P.L.2
Escudero, R.3
Deutsch, R.4
Jamieson, S.W.5
-
11
-
-
9444247541
-
Persistent induction of HIF-1and -2in cardiomyocytes and stromal cells of ischemic myocardium
-
J urgensen JS, Rosenberger C, Wiesener MS,WarneckeC,Horstrup JH, et al. 2004. Persistent induction of HIF-1and -2in cardiomyocytes and stromal cells of ischemic myocardium. FASEB J. 18:1415-177
-
(2004)
FASEB J.
, vol.18
, pp. 1415-1187
-
-
Jurgensen, J.S.1
Rosenberger, C.2
Wiesener, M.S.3
Warnecke, C.4
Horstrup, J.H.5
-
12
-
-
18444380862
-
Expression of hypoxia-inducible factor 1 and 2 in hypoxic and ischemic rat kidneys
-
Rosenberger C, Mandriota S, J urgensen JS, Wiesener MS, Horstrup JH, et al. 2002. Expression of hypoxia-inducible factor 1and 2in hypoxic and ischemic rat kidneys. J. Am. Soc. Nephrol. 13:1721-322
-
(2002)
J. Am. Soc. Nephrol.
, vol.13
, pp. 1721-1332
-
-
Rosenberger, C.1
Mandriota, S.2
Jurgensen, J.S.3
Wiesener, M.S.4
Horstrup, J.H.5
-
13
-
-
0031753986
-
Temporal, spatial, and oxygenregulated expression of hypoxia-inducible factor 1 in the lung
-
Yu AY, Frid MG, Shimoda LA, Wiener CM, Stenmark K, et al. 1998. Temporal, spatial, and oxygenregulated expression of hypoxia-inducible factor 1 in the lung. Am. J. Physiol. Lung Cell. Mol. Physiol. 275:L818-266
-
(1998)
Am. J. Physiol. Lung Cell. Mol. Physiol.
, vol.275
-
-
Yu, A.Y.1
Frid, M.G.2
Shimoda, L.A.3
Wiener, C.M.4
Stenmark, K.5
-
14
-
-
37349115260
-
Effects of aging and hypoxiainducible factor 1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia
-
Bosch-Marce M, Okuyama H, Wesley JB, Sarkar K, Kimura H, et al. 2007. Effects of aging and hypoxiainducible factor 1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia. Circ. Res. 101:1310-188
-
(2007)
Circ. Res.
, vol.101
, pp. 1310-1198
-
-
Bosch-Marce, M.1
Okuyama, H.2
Wesley, J.B.3
Sarkar, K.4
Kimura, H.5
-
15
-
-
43649093915
-
Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
-
Kaelin WG Jr, Ratcliffe PJ. 2008. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol. Cell 30:393-4022
-
(2008)
Mol. Cell
, vol.30
, pp. 393-4022
-
-
Kaelin, JrW.G.1
Ratcliffe, P.J.2
-
16
-
-
0030460724
-
Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1
-
Semenza GL, Jiang BH, Leung SW, Passantino R, Concordet JP, et al. 1996. Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J. Biol. Chem. 271:32529-377
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 32529-32387
-
-
Semenza, G.L.1
Jiang, B.H.2
Leung, S.W.3
Passantino, R.4
Concordet, J.P.5
-
17
-
-
0026468180
-
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
-
Semenza GL, Wang GL. 1992. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol. Cell. Biol. 12:5447-544
-
(1992)
Mol. Cell. Biol.
, vol.12
, pp. 5447-5544
-
-
Semenza, G.L.1
Wang, G.L.2
-
18
-
-
63449103705
-
Integrative analysis of HIF binding and transactivation reveals its role inmaintaining histone methylation homeostasis
-
Xia X, Lemieux ME, Li W, Carroll JS, Brown M, et al. 2009. Integrative analysis of HIF binding and transactivation reveals its role inmaintaining histone methylation homeostasis. Proc. Natl. Acad. Sci. USA 106:4260-655
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 4260-4655
-
-
Xia, X.1
Lemieux, M.E.2
Li, W.3
Carroll, J.S.4
Brown, M.5
-
19
-
-
67650531089
-
Genome-wide association of hypoxia-inducible factor (HIF)-1 and HIF-2 DNA binding with expression profiling of hypoxiainducible transcripts
-
Mole DR, Blancher C, Copley RR, Pollard PJ, Gleadle JM, et al. 2009. Genome-wide association of hypoxia-inducible factor (HIF)-1 and HIF-2 DNA binding with expression profiling of hypoxiainducible transcripts. J. Biol. Chem. 284:16767-755
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 16767-16765
-
-
Mole, D.R.1
Blancher, C.2
Copley, R.R.3
Pollard, P.J.4
Gleadle, J.M.5
-
20
-
-
79959450883
-
High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq
-
Schodel J, Oikonomopoulos S, Ragoussis J, Pugh CW, Ratcliffe PJ, Mole DR. 2011. High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq. Blood 117:e207-177
-
(2011)
Blood 117:e207-177
-
-
Schodel, J.1
Oikonomopoulos, S.2
Ragoussis, J.3
Pugh, C.W.4
Ratcliffe, P.J.5
Mole, D.R.6
-
21
-
-
0344874751
-
Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1
-
Kelly BD,Hackett SF, Hirota K, Oshima Y,Cai Z, et al. 2003. Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1. Circ. Res. 93:1074-811
-
(2003)
Circ. Res.
, vol.93
, pp. 1074-1811
-
-
Kelly Bdhackett, S.F.1
Hirota, K.2
Oshima Ycai, Z.3
-
22
-
-
84855353573
-
Heart disease and stroke statistics-2012 update: A report from the American Heart Association
-
Am. Heart Assoc. Stat.Comm./Stroke Stat. Subcomm.
-
Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, et al. Am. Heart Assoc. Stat.Comm./Stroke Stat. Subcomm. 2012. Heart disease and stroke statistics -2012 update: a report from the American Heart Association. Circulation 125:e2-2200
-
(2012)
Circulation
, vol.125
-
-
Roger, V.L.1
Go, A.S.2
Lloyd-Jones, D.M.3
Benjamin, E.J.4
Berry, J.D.5
-
23
-
-
0037407403
-
NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older
-
Alexander CM, Landsman PB, Teutsch SM, Haffner SM. 2003. NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older. Diabetes 52:1210-144
-
(2003)
Diabetes
, vol.52
, pp. 1210-1154
-
-
Alexander, C.M.1
Landsman, P.B.2
Teutsch, S.M.3
Haffner, S.M.4
-
24
-
-
0025978583
-
Influence of coronary collateral vessels on myocardial infarct size in humans
-
Habib GB, Heibig J, Forman SA, Brown BG, Roberts R, et al. 1991. Influence of coronary collateral vessels on myocardial infarct size in humans. Results of phase I thrombolysis in myocardial infarction (TIMI) trial. Circulation 83:739-466
-
(1991)
Results of Phase i Thrombolysis in Myocardial Infarction (TIMI) Trial. Circulation
, vol.83
, pp. 739-466
-
-
Habib, G.B.1
Heibig, J.2
Forman, S.A.3
Brown, B.G.4
Roberts, R.5
-
25
-
-
0027103789
-
An association between collateral blood flow and myocardial viability in patients with recent myocardial infarction
-
Sabia PJ, Powers ER, Ragosta M, Sarembock IJ, Burwell LR, et al. 1992. An association between collateral blood flow and myocardial viability in patients with recent myocardial infarction. N. Engl. J. Med. 327:1825-311
-
(1992)
N. Engl. J. Med.
, vol.327
, pp. 1825-1321
-
-
Sabia, P.J.1
Powers, E.R.2
Ragosta, M.3
Sarembock, I.J.4
Burwell, L.R.5
-
26
-
-
0033547805
-
Age-dependent impairment of angiogenesis
-
Rivard A, Fabre JE, Silver M, Chen D, Murohara T, et al. 1999. Age-dependent impairment of angiogenesis. Circulation 99:111-200
-
(1999)
Circulation
, vol.99
, pp. 111-200
-
-
Rivard, A.1
Fabre, J.E.2
Silver, M.3
Chen, D.4
Murohara, T.5
-
27
-
-
24344433563
-
Constitutively active HIF-1 improves perfusion and arterial remodeling in an endovascular model of limb ischemia
-
Patel TH, Kimura H, Weiss CR, Semenza GL, Hofmann LV. 2005. Constitutively active HIF-1 improves perfusion and arterial remodeling in an endovascular model of limb ischemia. Cardiovasc. Res. 68:144-544
-
(2005)
Cardiovasc. Res.
, vol.68
, pp. 144-544
-
-
Patel, T.H.1
Kimura, H.2
Weiss, C.R.3
Semenza, G.L.4
Hofmann, L.V.5
-
28
-
-
73949085704
-
Synergistic effect of HIF-1gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia
-
Rey S, Lee K, Wang CJ, Gupta K, Chen S, et al. 2009. Synergistic effect of HIF-1gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia. Proc. Natl. Acad. Sci. USA 106:20399-4044
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 20399-24044
-
-
Rey, S.1
Lee, K.2
Wang, C.J.3
Gupta, K.4
Chen, S.5
-
29
-
-
79955962513
-
Metabolic reprogramming by HIF-1 promotes the survival of bone marrow-derived angiogenic cells in ischemic tissue
-
Rey S, Luo W, Shimoda LA, Semenza GL. 2011. Metabolic reprogramming by HIF-1 promotes the survival of bone marrow-derived angiogenic cells in ischemic tissue. Blood 117:4988-988
-
(2011)
Blood
, vol.117
, pp. 4988-4988
-
-
Rey, S.1
Luo, W.2
Shimoda, L.A.3
Semenza, G.L.4
-
30
-
-
84873108883
-
Angiogenetic potential of Ad2/Hif-1/VP16 after regional application in a preclinical pig model of chronic ischemia
-
Hinkel R, Lebherz C, Fydanaki M, Wuchrer A, El-Aouni C, et al. 2013. Angiogenetic potential of Ad2/Hif-1/VP16 after regional application in a preclinical pig model of chronic ischemia. Curr. Vasc. Pharmacol. 11:29-377
-
(2013)
Curr. Vasc. Pharmacol.
, vol.11
, pp. 29-377
-
-
Hinkel, R.1
Lebherz, C.2
Fydanaki, M.3
Wuchrer, A.4
El-Aouni, C.5
-
31
-
-
77951738011
-
Myocardial transfection of hypoxiainducible factor 1via an adenoviral vector during coronary artery bypass grafting
-
Kilian EG, Sadoni S, Vicol C, Kelly R, van Hulst K, et al. 2010. Myocardial transfection of hypoxiainducible factor 1via an adenoviral vector during coronary artery bypass grafting. A multicenter phase I and safety study. Circ. J. 74:916-244
-
(2010)
A Multicenter Phase i and Safety Study. Circ. J.
, vol.74
, pp. 916-244
-
-
Kilian, E.G.1
Sadoni, S.2
Vicol, C.3
Kelly, R.4
Van Hulst, K.5
-
32
-
-
23744461969
-
Hypoxia-inducible factor 1 polymorphism and coronary collaterals in patients with ischemic heart disease
-
Resar JR, Roguin A, Voner J, Nasir K, Hennebry TA, et al. 2005. Hypoxia-inducible factor 1 polymorphism and coronary collaterals in patients with ischemic heart disease. Chest 128:787-911
-
(2005)
Chest
, vol.128
, pp. 787-911
-
-
Resar, J.R.1
Roguin, A.2
Voner, J.3
Nasir, K.4
Hennebry, T.A.5
-
33
-
-
36148973202
-
Polymorphisms in hypoxia inducible factor 1 and the initial clinical presentation of coronary disease
-
Hlatky MA, Quertermous T, Boothroyd DB, Priest JR, Glassford AJ, et al. 2007. Polymorphisms in hypoxia inducible factor 1 and the initial clinical presentation of coronary disease. Am.Heart J. 154:1035-422
-
(2007)
Am.Heart J.
, vol.154
, pp. 1035-1422
-
-
Hlatky, M.A.1
Quertermous, T.2
Boothroyd, D.B.3
Priest, J.R.4
Glassford, A.J.5
-
34
-
-
84858733754
-
The HIF1A C85T polymorphism influences the number of branches of the human coronary tree
-
Duran J, Gotzens V, Carballo J, Martin E, Petit M, et al. 2012. The HIF1A C85T polymorphism influences the number of branches of the human coronary tree. Cardiology 121:156-599
-
(2012)
Cardiology
, vol.121
, pp. 156-599
-
-
Duran, J.1
Gotzens, V.2
Carballo, J.3
Martin, E.4
Petit, M.5
-
35
-
-
35348941718
-
Time to treatment in primary percutaneous coronary intervention
-
Nallamothu BK, Bradley EH, Krumholz HM. 2007. Time to treatment in primary percutaneous coronary intervention. N. Engl. J. Med. 357:1631-388
-
(2007)
N. Engl. J. Med.
, vol.357
, pp. 1631-1398
-
-
Nallamothu, B.K.1
Bradley, E.H.2
Krumholz, H.M.3
-
36
-
-
0022402059
-
Myocardial reperfusion: A double-edged sword?
-
Braunwald E, Kloner RA. 1985. Myocardial reperfusion: a double-edged sword? J. Clin. Investig. 76:1713-199
-
(1985)
J. Clin. Investig.
, vol.76
, pp. 1713-1199
-
-
Braunwald, E.1
Kloner, R.A.2
-
37
-
-
0022970945
-
Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium
-
Murry CE, Jennings RB, Reimer KA. 1986. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74:1124-366
-
(1986)
Circulation
, vol.74
, pp. 1124-1366
-
-
Murry, C.E.1
Jennings, R.B.2
Reimer, K.A.3
-
38
-
-
0027222962
-
Delayed effects of sublethal ischemia on the acquisition of tolerance to ischemia
-
Kuzuya T, Hoshida S, Yamashita N, Fuji H, Oe H, et al. 1993. Delayed effects of sublethal ischemia on the acquisition of tolerance to ischemia. Circ. Res. 72:1293-999
-
(1993)
Circ. Res.
, vol.72
, pp. 1293-1999
-
-
Kuzuya, T.1
Hoshida, S.2
Yamashita, N.3
Fuji, H.4
Oe, H.5
-
39
-
-
0027163384
-
Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction
-
Marber MS, Latchman DS, Walker JM, Yellon DM. 1993. Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction. Circulation 88:1264-722
-
(1993)
Circulation
, vol.88
, pp. 1264-1722
-
-
Marber, M.S.1
Latchman, D.S.2
Walker, J.M.3
Yellon, D.M.4
-
40
-
-
0026047960
-
Protection against infarction afforded by preconditioning is mediated by A1 adenosine receptors in rabbit heart
-
Liu GS, Thornton J, Van Winkle DM, Stanley AW, Olsson RA, et al. 1991. Protection against infarction afforded by preconditioning is mediated by A1 adenosine receptors in rabbit heart. Circulation 84:350-566
-
(1991)
Circulation
, vol.84
, pp. 350-566
-
-
Liu, G.S.1
Thornton, J.2
Van Winkle, D.M.3
Stanley, A.W.4
Olsson, R.A.5
-
41
-
-
38849182762
-
Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1?
-
Cai Z, Zhong H, Bosch-Marce M, Fox-Talbot K, Wang L, et al. 2008. Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1?. Cardiovasc. Res. 77:463-700
-
(2008)
Cardiovasc. Res.
, vol.77
, pp. 463-700
-
-
Cai, Z.1
Zhong, H.2
Bosch-Marce, M.3
Fox-Talbot, K.4
Wang, L.5
-
42
-
-
84862991047
-
Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning
-
Sarkar K, Cai Z, Gupta R, Parajuli N, Fox-Talbot K, et al. 2012. Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning. Proc. Natl. Acad. Sci. USA 109:10504-99
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 10504-10599
-
-
Sarkar, K.1
Cai, Z.2
Gupta, R.3
Parajuli, N.4
Fox-Talbot, K.5
-
43
-
-
0027933411
-
Adenosine receptor specificity in preconditioning of isolated rabbit cardiomyocytes: Evidence of A3 receptor involvement
-
Armstrong S, Ganote CE. 1994. Adenosine receptor specificity in preconditioning of isolated rabbit cardiomyocytes: evidence of A3 receptor involvement. Cardiovasc. Res. 28:1049-566
-
(1994)
Cardiovasc. Res.
, vol.28
, pp. 1049-1566
-
-
Armstrong, S.1
Ganote, C.E.2
-
44
-
-
34247343418
-
Cardioprotection by ecto-5 -Nucleotidase (CD73) and A2B adenosine receptors
-
Eckle T, Krahn T, Grenz A, Kohler D, Mittelbronn M, et al. 2007. Cardioprotection by ecto-5 -nucleotidase (CD73) and A2B adenosine receptors. Circulation 115:1581-900
-
(2007)
Circulation
, vol.115
, pp. 1581-1900
-
-
Eckle, T.1
Krahn, T.2
Grenz, A.3
Kohler, D.4
Mittelbronn, M.5
-
45
-
-
37349104240
-
CD39/ectonucleoside triphosphate diphosphohydrolase 1 provides myocardial protection during cardiac ischemia/reperfusion injury
-
Kohler D, Eckle T, Faigle M, Grenz A, Mittelbronn M, et al. 2007. CD39/ectonucleoside triphosphate diphosphohydrolase 1 provides myocardial protection during cardiac ischemia/reperfusion injury. Circulation 116:1784-944
-
(2007)
Circulation
, vol.116
, pp. 1784-1944
-
-
Kohler, D.1
Eckle, T.2
Faigle, M.3
Grenz, A.4
Mittelbronn, M.5
-
46
-
-
47649128513
-
Hypoxia-inducible factor 1 is central to cardioprotection: A new paradigm for ischemic preconditioning
-
Eckle T, Kohler D, Lehmann R, El Kasmi K, Eltzschig HK. 2008. Hypoxia-inducible factor 1 is central to cardioprotection: a new paradigm for ischemic preconditioning. Circulation 118:166-755
-
(2008)
Circulation
, vol.118
, pp. 166-755
-
-
Eckle, T.1
Kohler, D.2
Lehmann, R.3
El Kasmi, K.4
Eltzschig, H.K.5
-
47
-
-
6344283049
-
Targeted disruption of cd73/ecto-5 -Nucleotidase alters thromboregulation and augments vascular inflammatory response
-
Koszalka P, Ozuyaman B, Huo Y, Zernecke A, Flogel U, et al. 2004. Targeted disruption of cd73/ecto-5 -nucleotidase alters thromboregulation and augments vascular inflammatory response. Circ. Res. 95:814-211
-
(2004)
Circ. Res.
, vol.95
, pp. 814-211
-
-
Koszalka, P.1
Ozuyaman, B.2
Huo, Y.3
Zernecke, A.4
Flogel, U.5
-
48
-
-
0030787469
-
Transactivation and inhibitory domains of hypoxia-inducible factor 1. Modulation of transcriptional activity by oxygen tension
-
Jiang BH, Zheng JZ, Leung SW, Roe R, Semenza GL. 1997. Transactivation and inhibitory domains of hypoxia-inducible factor 1. Modulation of transcriptional activity by oxygen tension. J. Biol. Chem. 272:19253-600
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 19253-19600
-
-
Jiang, B.H.1
Zheng, J.Z.2
Leung, S.W.3
Roe, R.4
Semenza, G.L.5
-
49
-
-
0038163900
-
Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury
-
Cai Z, Manalo DJ, Wei G, Rodriguez ER, Fox-Talbot K, et al. 2003. Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury. Circulation 108:79-855
-
(2003)
Circulation
, vol.108
, pp. 79-855
-
-
Cai, Z.1
Manalo, D.J.2
Wei, G.3
Rodriguez, E.R.4
Fox-Talbot, K.5
-
50
-
-
9344262366
-
Cobalt chloride induces delayed cardiac preconditioning in mice through selective activation of HIF-1and AP-1 and iNOS signaling
-
Xi L, Taher M, Yin C, Salloum F, Kukreja RC. 2004. Cobalt chloride induces delayed cardiac preconditioning in mice through selective activation of HIF-1and AP-1 and iNOS signaling. Am. J. Physiol. Heart Circ. Physiol. 287:H2369-755
-
(2004)
Am. J. Physiol. Heart Circ. Physiol.
, vol.287
-
-
Xi, L.1
Taher, M.2
Yin, C.3
Salloum, F.4
Kukreja, R.C.5
-
51
-
-
23744443462
-
HIF-1 activation attenuates postischemic myocardial injury: Role for heme oxygenase-1 in modulating microvascular chemokine generation
-
Ockaili R, Natarajan R, Salloum F, Fisher BJ, Jones D, et al. 2005. HIF-1 activation attenuates postischemic myocardial injury: role for heme oxygenase-1 in modulating microvascular chemokine generation. Am. J. Physiol. Heart Circ. Physiol. 289:H542-488
-
(2005)
Am. J. Physiol. Heart Circ. Physiol.
, vol.289
-
-
Ockaili, R.1
Natarajan, R.2
Salloum, F.3
Fisher, B.J.4
Jones, D.5
-
52
-
-
0033976342
-
Hypoxic regulation of inducible nitric oxide synthase via hypoxia-inducible factor 1 in cardiac myocytes
-
Jung F, Palmer LA, Zhou N, Johns RA. 2000. Hypoxic regulation of inducible nitric oxide synthase via hypoxia-inducible factor 1 in cardiac myocytes. Circ. Res. 86:319-255
-
(2000)
Circ. Res.
, vol.86
, pp. 319-255
-
-
Jung, F.1
Palmer, L.A.2
Zhou, N.3
Johns, R.A.4
-
53
-
-
84866601479
-
Regulation of metabolism by hypoxia-inducible factor 1
-
Semenza GL. 2011. Regulation of metabolism by hypoxia-inducible factor 1. Cold Spring Harb. Symp. Quant. Biol. 76:347-533
-
(2011)
Cold Spring Harb. Symp. Quant. Biol.
, vol.76
, pp. 347-533
-
-
Semenza, G.L.1
-
54
-
-
33947724515
-
HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells
-
Fukuda R, Zhang H, Kim JW, Shimoda L, Dang CV, et al. 2007. HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. Cell 129:111-222
-
(2007)
Cell
, vol.129
, pp. 111-222
-
-
Fukuda, R.1
Zhang, H.2
Kim, J.W.3
Shimoda, L.4
Dang, C.V.5
-
55
-
-
33644614520
-
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
-
Kim JW, Tchernyshyov I, Semenza GL, Dang CV. 2006. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. CellMetab. 3:177-855
-
(2006)
CellMetab.
, vol.3
, pp. 177-855
-
-
Kim, J.W.1
Tchernyshyov, I.2
Semenza, G.L.3
Dang, C.V.4
-
56
-
-
33644622570
-
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
-
Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC. 2006. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab. 3:187-977
-
(2006)
Cell Metab.
, vol.3
, pp. 187-977
-
-
Papandreou, I.1
Cairns, R.A.2
Fontana, L.3
Lim, A.L.4
Denko, N.C.5
-
57
-
-
57649130593
-
Induction of pyruvate dehydrogenase kinase 3 by hypoxia-inducible factor 1 promotes metabolic switch and drug resistance
-
Lu CW, Lin SC, Chen KF, Lai YY, Tsai SJ. 2008. Induction of pyruvate dehydrogenase kinase 3 by hypoxia-inducible factor 1 promotes metabolic switch and drug resistance. J. Biol. Chem. 283:28106-144
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 28106-28144
-
-
Lu, C.W.1
Lin, S.C.2
Chen, K.F.3
Lai, Y.Y.4
Tsai, S.J.5
-
58
-
-
70349478990
-
MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2
-
Chan SY, Zhang YY, Hemann C, Mahoney CE, Zweier JL, et al. 2009. MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2. Cell Metab. 10:273-844
-
(2009)
Cell Metab.
, vol.10
, pp. 273-844
-
-
Chan, S.Y.1
Zhang, Y.Y.2
Hemann, C.3
Mahoney, C.E.4
Zweier, J.L.5
-
59
-
-
77956402239
-
MicroRNA-210 regulates mitochondrial free radical response to hypoxia and Krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU
-
Favaro E, Ramachandran A, McCormick R, Gee H, Blancher C, et al. 2010. MicroRNA-210 regulates mitochondrial free radical response to hypoxia and Krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU. PLoS ONE 5:e103455
-
(2010)
PLoS ONE
, vol.5
-
-
Favaro, E.1
Ramachandran, A.2
McCormick, R.3
Gee, H.4
Blancher, C.5
-
60
-
-
43649104579
-
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia
-
Zhang H, Bosch-Marce M, Shimoda LA, Tan YS, Baek JH, et al. 2008. Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J. Biol. Chem. 283:10892-9033
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 10892-19033
-
-
Zhang, H.1
Bosch-Marce, M.2
Shimoda, L.A.3
Tan, Y.S.4
Baek, J.H.5
-
61
-
-
66349121718
-
Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains
-
Bellot G, Garcia-Medina R, Gounon P, Chiche J, Roux D, et al. 2009. Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol. Cell. Biol. 29:2570-811
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 2570-2811
-
-
Bellot, G.1
Garcia-Medina, R.2
Gounon, P.3
Chiche, J.4
Roux, D.5
-
62
-
-
77649126524
-
Heart disease and stroke statistics-2010 update: A report from the American Heart Association
-
Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, et al. 2010. Heart disease and stroke statistics -2010 update: a report from the American Heart Association. Circulation 121:e46-2155
-
(2010)
Circulation 121:e46-2155
-
-
Lloyd-Jones, D.1
Adams, R.J.2
Brown, T.M.3
Carnethon, M.4
Dai, S.5
-
63
-
-
0025280867
-
Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study
-
Levy D, Garrison RJ, Savage DD, Dannel WB, Castelli WP. 1990. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N. Engl. J. Med. 322:1561-666
-
(1990)
N. Engl. J. Med.
, vol.322
, pp. 1561-1666
-
-
Levy, D.1
Garrison, R.J.2
Savage, D.D.3
Dannel, W.B.4
Castelli, W.P.5
-
64
-
-
0026645965
-
The heart in hypertension
-
Frohlich ED, Apstein C, Chobanian AV, Devereaux RB, Dustan HP, et al. 1992. The heart in hypertension. N. Engl. J. Med. 327:998-10088
-
(1992)
N. Engl. J. Med.
, vol.327
, pp. 998-10088
-
-
Frohlich, E.D.1
Apstein, C.2
Chobanian, A.V.3
Devereaux, R.B.4
Dustan, H.P.5
-
65
-
-
33947520124
-
P53-induced inhibition of HIF-1 causes cardiac dysfunction during pressure overload
-
Sano M, Minamino T, Toko H, Miyauchi H, Orimo M, et al. 2007. p53-induced inhibition of HIF-1 causes cardiac dysfunction during pressure overload. Nature 446:444-88
-
(2007)
Nature
, vol.446
, pp. 444-488
-
-
Sano, M.1
Minamino, T.2
Toko, H.3
Miyauchi, H.4
Orimo, M.5
-
66
-
-
84859469406
-
Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-βsignaling
-
Wei H, Bedja D, Koitabashi N, Xing D, Chen J, et al. 2012. Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-βsignaling. Proc. Natl. Acad. Sci. USA 109:E841-500
-
(2012)
Proc. Natl. Acad. Sci. USA 109:E841-500
-
-
Wei, H.1
Bedja, D.2
Koitabashi, N.3
Xing, D.4
Chen, J.5
-
67
-
-
79957888881
-
Pivotal role of cardiomyocyte TGF-β signaling in the murine pathological response to sustained pressure overload
-
Koitabashi N, Danner T, Zaiman AL, Pinto YM, Rowell J, et al. 2011. Pivotal role of cardiomyocyte TGF-β signaling in the murine pathological response to sustained pressure overload. J. Clin. Investig. 121:2301-122
-
(2011)
J. Clin. Investig.
, vol.121
, pp. 2301-2132
-
-
Koitabashi, N.1
Danner, T.2
Zaiman, A.L.3
Pinto, Y.M.4
Rowell, J.5
-
68
-
-
58149374576
-
Digoxin and other cardiac glycosides inhibit HIF-1synthesis and block tumor growth
-
Zhang H, Qian DZ, Tan YS, Lee K, Gao P, et al. 2008. Digoxin and other cardiac glycosides inhibit HIF-1synthesis and block tumor growth. Proc. Natl. Acad. Sci. USA 105:19579-866
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 19579-19866
-
-
Zhang, H.1
Qian, D.Z.2
Tan, Y.S.3
Lee, K.4
Gao, P.5
-
70
-
-
0036284578
-
Gene regulatory mechanisms governing energy metabolism during cardiac hypertrophic growth
-
Lehman JJ, Kelly DP. 2002. Gene regulatory mechanisms governing energy metabolism during cardiac hypertrophic growth. Heart Fail. Rev. 7:175-855
-
(2002)
Heart Fail. Rev.
, vol.7
, pp. 175-855
-
-
Lehman, J.J.1
Kelly, D.P.2
-
71
-
-
3042711537
-
Linking gene expression to function: Metabolic flexibility in the normal and diseased heart
-
Taegtmeyer H, Golfman L, Sharma S, van Arsdall M. 2004. Linking gene expression to function: metabolic flexibility in the normal and diseased heart. Ann. NY Acad. Sci. 1015:202-133
-
(2004)
Ann. NY Acad. Sci.
, vol.1015
, pp. 202-133
-
-
Taegtmeyer, H.1
Golfman, L.2
Sharma, S.3
Van Arsdall, M.4
-
72
-
-
66049097308
-
Activation of a HIF-1-PPAR axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy
-
Krishnan J, Suter M, Windak R, Krebs T, Felley A, et al. 2009. Activation of a HIF-1-PPAR axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy. Cell Metab. 9:512-244
-
(2009)
Cell Metab.
, vol.9
, pp. 512-244
-
-
Krishnan, J.1
Suter, M.2
Windak, R.3
Krebs, T.4
Felley, A.5
-
73
-
-
77950928632
-
Impaired Ca2+ handling inHIF-1+/ mice as a consequence of pressure overload
-
Silter M, Kogler H, Zieseniss A,Wilting J, Schafer K, et al. 2010. Impaired Ca2+ handling inHIF-1+/ mice as a consequence of pressure overload. Pflug. Arch. 459:569-777
-
(2010)
Pflug. Arch.
, vol.459
, pp. 569-777
-
-
Silter, M.1
Kogler, H.2
Zieseniss, A.3
Wilting, J.4
Schafer, K.5
-
74
-
-
79957567239
-
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1
-
Luo W, Hu H, Chang R, Zhong J, Knabel M, et al. 2011. Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell 145:732-444
-
(2011)
Cell
, vol.145
, pp. 732-444
-
-
Luo, W.1
Hu, H.2
Chang, R.3
Zhong, J.4
Knabel, M.5
-
75
-
-
84867087464
-
Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells
-
Schito L, Rey S, Tafani M, Zhang H, Wong CC, et al. 2012. Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells. Proc. Natl. Acad. Sci. USA 109:E2707-166
-
(2012)
Proc. Natl. Acad. Sci. USA 109:E2707-166
-
-
Schito, L.1
Rey, S.2
Tafani, M.3
Zhang, H.4
Wong, C.C.5
-
76
-
-
84873804360
-
Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis
-
Chaturvedi P, Gilkes DM, Wong CC, Kshitiz, Luo W, et al. 2013. Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. J. Clin. Investig. 123:189-2055
-
(2013)
J. Clin. Investig.
, vol.123
, pp. 189-2055
-
-
Chaturvedi, P.1
Gilkes, D.M.2
Wong, C.C.3
Kshitiz Luo, W.4
-
77
-
-
84860389759
-
HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs
-
Zhang H, Wong CC, Wei H, Gilkes DM, Korangath P, et al. 2012. HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs. Oncogene 31:1757-700
-
(2012)
Oncogene
, vol.31
, pp. 1757-1710
-
-
Zhang, H.1
Wong, C.C.2
Wei, H.3
Gilkes, D.M.4
Korangath, P.5
-
78
-
-
0034647742
-
Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency
-
Mukhopadhyay CK, Mazumder B, Fox PL. 2000. Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency. J. Biol. Chem. 275:21048-544
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 21048-21544
-
-
Mukhopadhyay, C.K.1
Mazumder, B.2
Fox, P.L.3
-
79
-
-
0034255036
-
Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
-
Bruick RK. 2000. Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Proc. Natl. Acad. Sci. USA 97:9082-877
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 9082-9877
-
-
Bruick, R.K.1
-
80
-
-
38949202308
-
Integrin-linked kinase: A hypoxia-induced anti-apoptotic factor exploited by cancer cells
-
Abboud ER, Coffelt SB, Figueroa YG, Zwezdaryk KJ, Nelson AB, et al. 2007. Integrin-linked kinase: a hypoxia-induced anti-apoptotic factor exploited by cancer cells. Int. J. Oncol. 30:112-222
-
(2007)
Int. J. Oncol.
, vol.30
, pp. 112-222
-
-
Abboud, E.R.1
Coffelt, S.B.2
Figueroa, Y.G.3
Zwezdaryk, K.J.4
Nelson, A.B.5
-
81
-
-
34247614521
-
HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity
-
Zhang H, Gao P, Fukuda R, Kumar G, Krishnamachary B, et al. 2007. HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell 11:407-200
-
(2007)
Cancer Cell
, vol.11
, pp. 407-200
-
-
Zhang, H.1
Gao, P.2
Fukuda, R.3
Kumar, G.4
Krishnamachary, B.5
-
82
-
-
0032504165
-
Adrenomedullin gene expression is developmentally regulated and induced by hypoxia in rat ventricular cardiac myocytes
-
Cormier-Regard S, Nguyen SV, Claycomb WC. 1998. Adrenomedullin gene expression is developmentally regulated and induced by hypoxia in rat ventricular cardiac myocytes. J. Biol. Chem. 273:17787-922
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 17787-17922
-
-
Cormier-Regard, S.1
Nguyen, S.V.2
Claycomb, W.C.3
-
83
-
-
11244315697
-
Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1
-
Manalo DJ, Rowan A, Lavoie T, Natarajan L, Kelly BD, et al. 2005. Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1. Blood 105:659-699
-
(2005)
Blood
, vol.105
, pp. 659-699
-
-
Manalo, D.J.1
Rowan, A.2
Lavoie, T.3
Natarajan, L.4
Kelly, B.D.5
-
84
-
-
72449200648
-
Intermedin/adrenomedullin-2 is a hypoxia-induced endothelial peptide that stabilizes pulmonary microvascular permeability
-
Pfeil U, Aslam M, Paddenberg R, Quanz K, Chang CL, et al. 2009. Intermedin/adrenomedullin-2 is a hypoxia-induced endothelial peptide that stabilizes pulmonary microvascular permeability.Am. J. Physiol. Lung Cell. Mol. Physiol. 297:L837-455
-
(2009)
Am. J. Physiol. Lung Cell. Mol. Physiol.
, vol.297
-
-
Pfeil, U.1
Aslam, M.2
Paddenberg, R.3
Quanz, K.4
Chang, C.L.5
-
85
-
-
67649804934
-
Adenosine A2A receptor is a unique angiogenic target of HIF-2in pulmonary endothelial cells
-
Ahmad A, Ahmad S, Glover L, Miller SM, Shannon JM, et al. 2009. Adenosine A2A receptor is a unique angiogenic target of HIF-2in pulmonary endothelial cells. Proc. Natl. Acad. Sci. USA 106:10684-899
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 10684-10899
-
-
Ahmad, A.1
Ahmad, S.2
Glover, L.3
Miller, S.M.4
Shannon, J.M.5
-
86
-
-
33845604971
-
HIF-dependent induction of adenosine A2B receptor in hypoxia
-
Kong T, Westerman KA, Faigle M, Eltzschig HK, Colgan SP. 2006. HIF-dependent induction of adenosine A2B receptor in hypoxia. FASEB J. 20:2242-500
-
(2006)
FASEB J.
, vol.20
, pp. 2242-2500
-
-
Kong, T.1
Westerman, K.A.2
Faigle, M.3
Eltzschig, H.K.4
Colgan, S.P.5
-
87
-
-
0030611360
-
Characterization of the 1B-adrenergic receptor gene promoter region and hypoxia regulatory elements in vascular smooth muscle
-
Eckhart AD, Yang N, Xin X, Faber JE. 1997. Characterization of the 1B-adrenergic receptor gene promoter region and hypoxia regulatory elements in vascular smooth muscle. Proc. Natl. Acad. Sci. USA 94:9487-922
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 9487-9922
-
-
Eckhart, A.D.1
Yang, N.2
Xin, X.3
Faber, J.E.4
-
88
-
-
54049146968
-
The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1
-
Simon MP, Tournaire R, Pouyssegur J. 2008. The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1. J. Cell. Physiol. 217:809-188
-
(2008)
J. Cell. Physiol.
, vol.217
, pp. 809-188
-
-
Simon, M.P.1
Tournaire, R.2
Pouyssegur, J.3
-
89
-
-
50949099615
-
Hypoxia-induced apelin expression regulates endothelial cell proliferation and regenerative angiogenesis
-
Eyries M, Siegfried G, Ciumas M, Montagne K, Agrapart M, et al. 2008. Hypoxia-induced apelin expression regulates endothelial cell proliferation and regenerative angiogenesis. Circ. Res. 103:432-400
-
(2008)
Circ. Res.
, vol.103
, pp. 432-400
-
-
Eyries, M.1
Siegfried, G.2
Ciumas, M.3
Montagne, K.4
Agrapart, M.5
-
90
-
-
34249660052
-
Hypoxia-inducible factor-1 (HIF-1) is involved in the regulation of hypoxia-stimulated expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) and MCP-5 (Ccl12) in astrocytes
-
Mojsilovic-Petrovic J, Callaghan D, Cui H, Dean C, Stanimirovic DB, et al. 2007. Hypoxia-inducible factor-1 (HIF-1) is involved in the regulation of hypoxia-stimulated expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) and MCP-5 (Ccl12) in astrocytes. J. Neuroinflamm. 4:122
-
(2007)
J. Neuroinflamm.
, vol.4
, pp. 122
-
-
Mojsilovic-Petrovic, J.1
Callaghan, D.2
Cui, H.3
Dean, C.4
Stanimirovic, D.B.5
-
91
-
-
8644229386
-
Hypoxic induction of CTGF is directly mediated by HIF-1
-
Higgins DF, Biju MP, Akai Y, Wutz A, Johnson RS, et al. 2004. Hypoxic induction of CTGF is directly mediated by HIF-1. Am. J. Physiol. Ren. Physiol. 287:F1223-322
-
(2004)
Am. J. Physiol. Ren. Physiol.
, vol.287
-
-
Higgins, D.F.1
Biju, M.P.2
Akai, Y.3
Wutz, A.4
Johnson, R.S.5
-
92
-
-
10744219598
-
Regulation of the chemokine receptor CXCR4 by hypoxia
-
Schioppa T, Uranchimeg B, Saccani A, Biswas SK, Doni A, et al. 2003. Regulation of the chemokine receptor CXCR4 by hypoxia. J. Exp. Med. 198:1391-4022
-
(2003)
J. Exp. Med.
, vol.198
, pp. 1391-4022
-
-
Schioppa, T.1
Uranchimeg, B.2
Saccani, A.3
Biswas, S.K.4
Doni, A.5
-
93
-
-
0032576971
-
Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand
-
Hu J, Discher DJ, Bishopric NH, Webster KA. 1998. Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand. Biochem. Biophys. Res. Commun. 245:894-999
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.245
, pp. 894-999
-
-
Hu, J.1
Discher, D.J.2
Bishopric, N.H.3
Webster, K.A.4
-
94
-
-
0035183438
-
Attenuation of HIF-1 DNA-binding activity limits hypoxia-inducible endothelin-1 expression
-
Camenisch G, Stroka DM, Gassmann W, Wenger RH. 2001. Attenuation of HIF-1 DNA-binding activity limits hypoxia-inducible endothelin-1 expression. Pflug. Arch. 443:240-499
-
(2001)
Pflug. Arch.
, vol.443
, pp. 240-499
-
-
Camenisch, G.1
Stroka, D.M.2
Gassmann, W.3
Wenger, R.H.4
-
95
-
-
50949112902
-
Placenta growth factor augments endothelin-1 and endothelin-B receptor expression via hypoxia-inducible factor-1?
-
Patel N, Gonsalves CS, Malik P, Kalra VK. 2008. Placenta growth factor augments endothelin-1 and endothelin-B receptor expression via hypoxia-inducible factor-1?. Blood 112:856-655
-
(2008)
Blood
, vol.112
, pp. 856-655
-
-
Patel, N.1
Gonsalves, C.S.2
Malik, P.3
Kalra, V.K.4
-
96
-
-
26444553595
-
Hypoxia up-regulates expression of Eph receptors and ephrins in mouse skin
-
Vihanto MM, Plock J, Emi D, Frey BM, Frey FJ, et al. 2005. Hypoxia up-regulates expression of Eph receptors and ephrins in mouse skin. FASEB J. 19:1689-911
-
(2005)
FASEB J.
, vol.19
, pp. 1689-1911
-
-
Vihanto, M.M.1
Plock, J.2
Emi, D.3
Frey, B.M.4
Frey, F.J.5
-
97
-
-
49649115935
-
Hypoxia-inducible transcription factor 2in endothelial cells regulates tumor neovascularization through activation of ephrin A1
-
Yamashita T, Ohneda K, Nagano M, Miyoshi C, Kaneko N, et al. 2008. Hypoxia-inducible transcription factor 2in endothelial cells regulates tumor neovascularization through activation of ephrin A1. J. Biol. Chem. 283:18926-366
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 18926-18376
-
-
Yamashita, T.1
Ohneda, K.2
Nagano, M.3
Miyoshi, C.4
Kaneko, N.5
-
98
-
-
0037113959
-
Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-βpathways
-
Sanchez-Elsner T, Botella LM, Velasco B, Langa C, Bernabeu C. 2002. Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-βpathways. J. Biol. Chem. 277:43799-8088
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 43799-48088
-
-
Sanchez-Elsner, T.1
Botella, L.M.2
Velasco, B.3
Langa, C.4
Bernabeu, C.5
-
99
-
-
0030751493
-
Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes
-
Gerber HP, Condorelli F, Park J, Ferrara N. 1997. Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. J. Biol. Chem. 272:23659-677
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 23659-23677
-
-
Gerber, H.P.1
Condorelli, F.2
Park, J.3
Ferrara, N.4
-
100
-
-
33744959141
-
Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1
-
Okuyama H, Krishnamachary B, Zhou YF, Nagasawa H, Bosch-Marce M, et al. 2006. Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1. J. Biol. Chem. 281:15554-633
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 15554-15633
-
-
Okuyama, H.1
Krishnamachary, B.2
Zhou, Y.F.3
Nagasawa, H.4
Bosch-Marce, M.5
-
101
-
-
51849108509
-
Hypoxia-inducible factor (HIF)-1 directly enhances the transcriptional activity of stem cell factor (SCF) in response to hypoxia and epidermal growth factor (EGF)
-
Han ZB, Ren H, Zhao H, Chi Y, Chen K, et al. 2008. Hypoxia-inducible factor (HIF)-1 directly enhances the transcriptional activity of stem cell factor (SCF) in response to hypoxia and epidermal growth factor (EGF). Carcinogenesis 29:1853-611
-
(2008)
Carcinogenesis
, vol.29
, pp. 1853-1621
-
-
Han, Z.B.1
Ren, H.2
Zhao, H.3
Chi, Y.4
Chen, K.5
-
102
-
-
0037044813
-
Hypoxia-inducible factor 1 transactivates the human leptin gene promoter
-
Grosfeld A, Andre J, Hauguel-De Mouzon S, Berra E, Pouyssegur J, et al. 2002. Hypoxia-inducible factor 1 transactivates the human leptin gene promoter. J. Biol. Chem. 277:42953-577
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 42953-42587
-
-
Grosfeld, A.1
Andre, J.2
Hauguel-De Mouzon, S.3
Berra, E.4
Pouyssegur, J.5
-
103
-
-
4344569786
-
Midkine is regulated by hypoxia and causes pulmonary vascular remodeling
-
Reynolds PR, Mucenski ML, Le Cras TD, Nichols WC, Whitsett JA. 2004. Midkine is regulated by hypoxia and causes pulmonary vascular remodeling. J. Biol. Chem. 279:37124-322
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 37124-37322
-
-
Reynolds, P.R.1
Mucenski, M.L.2
Le Cras, T.D.3
Nichols, W.C.4
Whitsett, J.A.5
-
104
-
-
0035974803
-
Identification of an angiogenic mitogen selective for endocrine gland endothelium
-
LeCouter J, Kowalski J, Foster J, Hass P, Zhang Z, et al. 2001. Identification of an angiogenic mitogen selective for endocrine gland endothelium. Nature 412:877-844
-
(2001)
Nature
, vol.412
, pp. 877-844
-
-
Lecouter, J.1
Kowalski, J.2
Foster, J.3
Hass, P.4
Zhang, Z.5
-
105
-
-
4043184065
-
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
-
Ceradini DJ, Kulkarni AR, Callaghan MJ, Tepper OM, Bastidas N, et al. 2004. Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat. Med. 10:858-644
-
(2004)
Nat. Med.
, vol.10
, pp. 858-644
-
-
Ceradini, D.J.1
Kulkarni, A.R.2
Callaghan, M.J.3
Tepper, O.M.4
Bastidas, N.5
-
106
-
-
0029761644
-
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
-
Forsythe JA, Jiang BH, Iyer NV, Agani F, Leung SW, et al. 1996. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell. Biol. 16:4604-133
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 4604-4143
-
-
Forsythe, J.A.1
Jiang, B.H.2
Iyer, N.V.3
Agani, F.4
Leung, S.W.5
-
107
-
-
0032100732
-
HIF-1 is required for solid tumor formation and embryonic vascularization
-
Ryan HE, Lo J, Johnson RS. 1998. HIF-1 is required for solid tumor formation and embryonic vascularization. EMBO J. 17:3005-155
-
(1998)
EMBO J.
, vol.17
, pp. 3005-3155
-
-
Ryan, H.E.1
Lo, J.2
Johnson, R.S.3
-
108
-
-
33751086440
-
Hypoxia results in an HIF-1-dependent induction of brainspecific aldolase C in lung epithelial cells
-
Jean JC, Rich CB, Joyce-Brady M. 2006. Hypoxia results in an HIF-1-dependent induction of brainspecific aldolase C in lung epithelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 291:L950-566
-
(2006)
Am. J. Physiol. Lung Cell. Mol. Physiol.
, vol.291
-
-
Jean, J.C.1
Rich, C.B.2
Joyce-Brady, M.3
-
109
-
-
0035884701
-
HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors
-
Sowter HM, Ratcliffe PJ,Watson P, Greenberg AH, Harris AL. 2001. HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Cancer Res. 61:6669-733
-
(2001)
Cancer Res.
, vol.61
, pp. 6669-6733
-
-
Sowter, H.M.1
Ratcliffe, P.J.2
Watson, P.3
Greenberg, A.H.4
Harris, A.L.5
-
110
-
-
0032741858
-
Identification of an oxygen responsive enhancer element in the glyceraldehyde-3-phosphate dehydrogenase gene
-
Graven KK, Yu Q, Pan D, Roncarati JS, Farber HW. 1999. Identification of an oxygen responsive enhancer element in the glyceraldehyde-3-phosphate dehydrogenase gene. Biochim. Biophys. Acta 1447:208-188
-
(1999)
Biochim. Biophys. Acta
, vol.1447
, pp. 208-188
-
-
Graven, K.K.1
Yu, Q.2
Pan, D.3
Roncarati, J.S.4
Farber, H.W.5
-
111
-
-
18544384240
-
Hypoxia enhances the expression of autocrine motility factor and the motility of human pancreatic cancer cells
-
Niizeki H, Kobayashi M, Horiuchi I, Akakura N, Chen J, et al. 2002. Hypoxia enhances the expression of autocrine motility factor and the motility of human pancreatic cancer cells. Br. J. Cancer 86:1914-199
-
(2002)
Br. J. Cancer
, vol.86
, pp. 1914-1199
-
-
Niizeki, H.1
Kobayashi, M.2
Horiuchi, I.3
Akakura, N.4
Chen, J.5
-
112
-
-
0028359320
-
Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: Similarities with the erythropoietin 3 enhancer
-
Firth JD, Ebert BL, Pugh CW, Ratcliffe PJ. 1994. Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3 enhancer. Proc. Natl. Acad. Sci. USA 91:6496-5000
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 6496-5000
-
-
Firth, J.D.1
Ebert, B.L.2
Pugh, C.W.3
Ratcliffe, P.J.4
-
113
-
-
0242710750
-
Hypoxic regulation of the 6-phosphofructo-2-kinase/fructose-2,6- bisphosphatase gene family (PFKFB-1-4) expression in vivo
-
Minchenko O, Opentanova I, Caro J. 2003. Hypoxic regulation of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene family (PFKFB-1-4) expression in vivo. FEBS Lett. 554:264-700
-
(2003)
FEBS Lett.
, vol.554
, pp. 264-700
-
-
Minchenko, O.1
Opentanova, I.2
Caro, J.3
-
114
-
-
0032581277
-
Role of HIF-1 in hypoxiamediated apoptosis, cell proliferation and tumour angiogenesis
-
Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, et al. 1998. Role of HIF-1 in hypoxiamediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394:485-900
-
(1998)
Nature
, vol.394
, pp. 485-900
-
-
Carmeliet, P.1
Dor, Y.2
Herbert, J.M.3
Fukumura, D.4
Brusselmans, K.5
-
115
-
-
0032478823
-
Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1-subunit (HIF-1)
-
Wood SM, Wiesener MS, Yeates KM, Okada N, Pugh CW, et al. 1998. Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1-subunit (HIF-1). Characterization of HIF-1-dependent and -independent hypoxia-inducible gene expression. J. Biol. Chem. 273:8360-688
-
(1998)
Characterization of HIF-1-dependent and -independent Hypoxia-inducible Gene Expression. J. Biol. Chem.
, vol.273
, pp. 8360-8688
-
-
Wood, S.M.1
Wiesener, M.S.2
Yeates, K.M.3
Okada, N.4
Pugh, C.W.5
-
116
-
-
33751117499
-
HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes
-
Shimoda LA, Fallon M, Pisarcik S, Wang J, Semenza GL. 2006. HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes. Am. J. Physiol. Lung Cell. Mol. Physiol. 291:L941-499
-
(2006)
Am. J. Physiol. Lung Cell. Mol. Physiol.
, vol.291
-
-
Shimoda, L.A.1
Fallon, M.2
Pisarcik, S.3
Wang, J.4
Semenza, G.L.5
-
117
-
-
33646917296
-
The plasma membrane lactate transporter MCT4, but not MCT1, is upregulated by hypoxia through aHIF-1-dependent mechanism
-
Ullah MS, Davies AJ, Halestrap AP. 2006. The plasma membrane lactate transporter MCT4, but not MCT1, is upregulated by hypoxia through aHIF-1-dependent mechanism. J. Biol. Chem. 281:9030-377
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 9030-9377
-
-
Ullah, M.S.1
Davies, A.J.2
Halestrap, A.P.3
-
118
-
-
77952673654
-
Imatinib resistance associated with BCRABL upregulation is dependent on HIF-1-induced metabolic reprograming
-
Zhao F, Mancuso A, Bui TV, Tong X, Gruber JJ, et al. 2010. Imatinib resistance associated with BCRABL upregulation is dependent on HIF-1-induced metabolic reprograming. Oncogene 29:2962-722
-
(2010)
Oncogene
, vol.29
, pp. 2962-2732
-
-
Zhao, F.1
Mancuso, A.2
Bui, T.V.3
Tong, X.4
Gruber, J.J.5
-
119
-
-
2442430224
-
Hypoxia upregulates triosephosphate isomerase expression via a HIF-dependent pathway
-
Gess B, Hofbauer KH, Deutzmann R, Kurtz A. 2004. Hypoxia upregulates triosephosphate isomerase expression via a HIF-dependent pathway. Pflug. Arch. 448:175-800
-
(2004)
Pflug. Arch.
, vol.448
, pp. 175-800
-
-
Gess, B.1
Hofbauer, K.H.2
Deutzmann, R.3
Kurtz, A.4
|