메뉴 건너뛰기




Volumn 117, Issue 18, 2011, Pages 4988-4998

Metabolic reprogramming by HIF-1 promotes the survival of bone marrow-derived angiogenic cells in ischemic tissue

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; CARBONATE DEHYDRATASE; CARRIER PROTEIN; DIMETHYLOXALYLGLYCINE; ENZYME; GLUCOSE; GLYCINE DERIVATIVE; HYPOXIA INDUCIBLE FACTOR 1; LACTIC ACID; MEMBRANE PROTEIN; MITOCHONDRIAL DNA; OXYGEN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

EID: 79955962513     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-11-321190     Document Type: Article
Times cited : (64)

References (50)
  • 3
    • 1842486565 scopus 로고    scopus 로고
    • Local Delivery of Marrow-Derived Stromal Cells Augments Collateral Perfusion Through Paracrine Mechanisms
    • DOI 10.1161/01.CIR.0000124062.31102.57
    • Kinnaird T, Stabile E, Burnett MS, et al. Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms. Circulation. 2004;109(12):1543-1549. (Pubitemid 38420184)
    • (2004) Circulation , vol.109 , Issue.12 , pp. 1543-1549
    • Kinnaird, T.1    Burnett, E.S.2    Shou, M.3    Lee, C.W.4    Barr, S.5    Fuchs, S.6    Epstein, S.E.7
  • 4
    • 0037418213 scopus 로고    scopus 로고
    • Peripheral blood "endothelial progenitor cells" are derived from monocyte/macrophages and secrete angiogenic growth factors
    • DOI 10.1161/01.CIR.0000058702.69484.A0
    • Rehman J, Li J, Orschell CM, March KL. Peripheral blood "endothelial progenitor cells" are derived from monocyte/macrophages and secrete angiogenic growth factors. Circulation. 2003;107(8):1164-1169. (Pubitemid 36297209)
    • (2003) Circulation , vol.107 , Issue.8 , pp. 1164-1169
    • Rehman, J.1    Li, J.2    Orschell, C.M.3    March, K.L.4
  • 5
    • 65649098704 scopus 로고    scopus 로고
    • Angiogenic monocytes: Another colorful blow to endothelial progenitors
    • Horrevoets AJ. Angiogenic monocytes: another colorful blow to endothelial progenitors. Am J Pathol. 2009;174(5):1594-1596.
    • (2009) Am J Pathol , vol.174 , Issue.5 , pp. 1594-1596
    • Horrevoets, A.J.1
  • 6
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loophelix-PAS heterodimer regulated by cellular O2 tension
    • Wang GL, Jiang BH, Rue EA, Semenza GL. Hypoxia-inducible factor 1 is a basic-helix-loophelix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci U S A. 1995;92(12):5510-5514.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , Issue.12 , pp. 5510-5514
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3    Semenza, G.L.4
  • 7
    • 47249111254 scopus 로고    scopus 로고
    • HIF-2alpha-haploinsufficient mice have blunted retinal neovascularization due to impaired expression of a proangiogenic gene battery
    • Dioum EM, Clarke SL, Ding K, Repa JJ, Garcia JA. HIF-2alpha- haploinsufficient mice have blunted retinal neovascularization due to impaired expression of a proangiogenic gene battery. Invest Ophthalmol Vis Sci. 2008;49(6):2714-2720.
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , Issue.6 , pp. 2714-2720
    • Dioum, E.M.1    Clarke, S.L.2    Ding, K.3    Repa, J.J.4    Garcia, J.A.5
  • 8
    • 67349119514 scopus 로고    scopus 로고
    • Regulation of angiogenesis by oxygen sensing mechanisms
    • Fong GH. Regulation of angiogenesis by oxygen sensing mechanisms. J Mol Med. 2009;87(6):549-560.
    • (2009) J Mol Med , vol.87 , Issue.6 , pp. 549-560
    • Fong, G.H.1
  • 9
    • 43649093915 scopus 로고    scopus 로고
    • Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
    • DOI 10.1016/j.molcel.2008.04.009, PII S109727650800292X
    • Kaelin WG Jr, Ratcliffe PJ. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell. 2008;30(4):393-402. (Pubitemid 351681994)
    • (2008) Molecular Cell , vol.30 , Issue.4 , pp. 393-402
    • Kaelin Jr., W.G.1    Ratcliffe, P.J.2
  • 13
    • 51849108509 scopus 로고    scopus 로고
    • Hypoxia-inducible factor (HIF)-1alpha directly enhances the transcriptional activity of stem cell factor (SCF) in response to hypoxia and epidermal growth factor (EGF)
    • Han ZB, Ren H, Zhao H, et al. Hypoxia-inducible factor (HIF)-1alpha directly enhances the transcriptional activity of stem cell factor (SCF) in response to hypoxia and epidermal growth factor (EGF). Carcinogenesis. 2008;29(10):1853-1861.
    • (2008) Carcinogenesis , vol.29 , Issue.10 , pp. 1853-1861
    • Han, Z.B.1    Ren, H.2    Zhao, H.3
  • 14
    • 54049146968 scopus 로고    scopus 로고
    • The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1
    • Simon MP, Tournaire R, Pouyssegur J. The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1. J Cell Physiol. 2008;217(3):809-818.
    • (2008) J Cell Physiol , vol.217 , Issue.3 , pp. 809-818
    • Simon, M.P.1    Tournaire, R.2    Pouyssegur, J.3
  • 17
    • 58049209727 scopus 로고    scopus 로고
    • Stabilization of HIF-1alpha is critical to improve wound healing in diabetic mice
    • Botusan IR, Sunkari VG, Savu O, et al. Stabilization of HIF-1alpha is critical to improve wound healing in diabetic mice. Proc Natl Acad Sci U S A. 2008;105(49):19426-19431.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.49 , pp. 19426-19431
    • Botusan, I.R.1    Sunkari, V.G.2    Savu, O.3
  • 18
    • 34848879004 scopus 로고    scopus 로고
    • Sustained expression of Hif-1α in the diabetic environment promotes angiogenesis and cutaneous wound repair
    • DOI 10.1111/j.1524-475X.2007.00278.x
    • Mace KA, Yu DH, Paydar KZ, Boudreau N, Young DM. Sustained expression of HIF-1alpha in the diabetic environment promotes angiogenesis and cutaneous wound repair. Wound Repair Regen. 2007;15(5):636-645. (Pubitemid 47493890)
    • (2007) Wound Repair and Regeneration , vol.15 , Issue.5 , pp. 636-645
    • Mace, K.A.1    Yu, D.H.2    Paydar, K.Z.3    Boudreau, N.4    Young, D.M.5
  • 19
    • 73249140173 scopus 로고    scopus 로고
    • Adenoviral transfer of HIF-1alpha enhances vascular responses to critical limb ischemia in diabetic mice
    • Sarkar K, Fox-Talbot K, Steenbergen C, Bosch-Marce M, Semenza GL. Adenoviral transfer of HIF-1alpha enhances vascular responses to critical limb ischemia in diabetic mice. Proc Natl Acad Sci U S A. 2009;106(44):18769-18774.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.44 , pp. 18769-18774
    • Sarkar, K.1    Fox-Talbot, K.2    Steenbergen, C.3    Bosch-Marce, M.4    Semenza, G.L.5
  • 20
    • 73949085704 scopus 로고    scopus 로고
    • Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia
    • Rey S, Lee K, Wang CJ, et al. Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia. Proc Natl Acad Sci U S A. 2009;106(48):20399-20404.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.48 , pp. 20399-20404
    • Rey, S.1    Lee, K.2    Wang, C.J.3
  • 21
    • 33947724515 scopus 로고    scopus 로고
    • HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
    • DOI 10.1016/j.cell.2007.01.047, PII S0092867407003078
    • Fukuda R, Zhang H, Kim JW, Shimoda L, Dang CV, Semenza GL. HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. Cell. 2007;129(1):111-122. (Pubitemid 46507584)
    • (2007) Cell , vol.129 , Issue.1 , pp. 111-122
    • Fukuda, R.1    Zhang, H.2    Kim, J.-W.3    Shimoda, L.4    Dang, C.V.5    Semenza, G.L.6
  • 22
    • 33644614520 scopus 로고    scopus 로고
    • HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
    • Kim JW, Tchernyshyov I, Semenza GL, Dang CV. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab. 2006;3(3):177-185.
    • (2006) Cell Metab , vol.3 , Issue.3 , pp. 177-185
    • Kim, J.W.1    Tchernyshyov, I.2    Semenza, G.L.3    Dang, C.V.4
  • 23
    • 33644622570 scopus 로고    scopus 로고
    • HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
    • Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab. 2006;3(3):187-197.
    • (2006) Cell Metab , vol.3 , Issue.3 , pp. 187-197
    • Papandreou, I.1    Cairns, R.A.2    Fontana, L.3    Lim, A.L.4    Denko, N.C.5
  • 24
    • 43649104579 scopus 로고    scopus 로고
    • Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia
    • Zhang H, Bosch-Marce M, Shimoda LA, et al. Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem. 2008;283(16):10892-10903.
    • (2008) J Biol Chem , vol.283 , Issue.16 , pp. 10892-10903
    • Zhang, H.1    Bosch-Marce, M.2    Shimoda, L.A.3
  • 29
    • 34447547148 scopus 로고    scopus 로고
    • Regulation of tumor pH and the role of carbonic anhydrase 9
    • DOI 10.1007/s10555-007-9064-0, Special issue on Hypoxia and Cancer, Guest Editor: Gregg L. Semenza
    • Swietach P, Vaughan-Jones RD, Harris AL. Regulation of tumor pH and the role of carbonic anhydrase 9. Cancer Metastasis Rev. 2007;26(2):299-310. (Pubitemid 47101667)
    • (2007) Cancer and Metastasis Reviews , vol.26 , Issue.2 , pp. 299-310
    • Swietach, P.1    Vaughan-Jones, R.D.2    Harris, A.L.3
  • 30
    • 33646917296 scopus 로고    scopus 로고
    • The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1α-dependent mechanism
    • DOI 10.1074/jbc.M511397200
    • Ullah MS, Davies AJ, Halestrap AP. The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism. J Biol Chem. 2006;281(14):9030-9037. (Pubitemid 43864615)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.14 , pp. 9030-9037
    • Ullah, M.S.1    Davies, A.J.2    Halestrap, A.P.3
  • 31
    • 34347215518 scopus 로고    scopus 로고
    • Analysis of apoptosis by propidium iodide staining and flow cytometry
    • Riccardi C, Nicoletti I. Analysis of apoptosis by propidium iodide staining and flow cytometry. Nat Protoc. 2006;1(3):1458-1461.
    • (2006) Nat Protoc , vol.1 , Issue.3 , pp. 1458-1461
    • Riccardi, C.1    Nicoletti, I.2
  • 32
    • 0019032544 scopus 로고
    • A model for the computer analysis of synchronous DNA distributions obtained by flow cytometry
    • Fox MH. A model for the computer analysis of synchronous DNA distributions obtained by flow cytometry. Cytometry. 1980;1(1):71-77.
    • (1980) Cytometry , vol.1 , Issue.1 , pp. 71-77
    • Fox, M.H.1
  • 33
    • 3442876969 scopus 로고    scopus 로고
    • Normalization of real-time quantitative reverse transcription-PCR data: A model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets
    • DOI 10.1158/0008-5472.CAN-04-0496
    • Andersen CL, Jensen JL, Orntoft TF. Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Cancer Res. 2004;64(15):5245-5250. (Pubitemid 39006544)
    • (2004) Cancer Research , vol.64 , Issue.15 , pp. 5245-5250
    • Andersen, C.L.1    Jensen, J.L.2    Orntoft, T.F.3
  • 34
    • 0242317675 scopus 로고    scopus 로고
    • Experimental validation of novel and conventional approaches to quantitative real-time PCR data analysis
    • Peirson SN, Butler JN, Foster RG. Experimental validation of novel and conventional approaches to quantitative real-time PCR data analysis. Nucleic Acids Res. 2003;31(14):e73.
    • (2003) Nucleic Acids Res , vol.31 , Issue.14
    • Peirson, S.N.1    Butler, J.N.2    Foster, R.G.3
  • 35
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001;29(9):e45.
    • (2001) Nucleic Acids Res , vol.29 , Issue.9
    • Pfaffl, M.W.1
  • 36
    • 85074914953 scopus 로고    scopus 로고
    • A PCR primer bank for quantitative gene expression analysis
    • Wang X, Seed B. A PCR primer bank for quantitative gene expression analysis. Nucleic Acids Res. 2003;31(24):e154.
    • (2003) Nucleic Acids Res , vol.31 , Issue.24
    • Wang, X.1    Seed, B.2
  • 37
    • 0001118572 scopus 로고
    • Solubility of oxygen in water
    • Truesdale GA, Downing AL. Solubility of oxygen in water. Nature. 1954;173(4417):1236.
    • (1954) Nature , vol.173 , Issue.4417 , pp. 1236
    • Truesdale, G.A.1    Downing, A.L.2
  • 38
    • 0033566693 scopus 로고    scopus 로고
    • Reciprocal positive regulation of hypoxia-inducible factor 1α and insulin-like growth factor 2
    • Feldser D, Agani F, Iyer NV, Pak B, Ferreira G, Semenza GL. Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2. Cancer Res. 1999;59(16):3915-3918. (Pubitemid 29393552)
    • (1999) Cancer Research , vol.59 , Issue.16 , pp. 3915-3918
    • Feldser, D.1    Agani, F.2    Iyer, N.V.3    Pak, B.4    Ferreira, G.5    Semenza, G.L.6
  • 39
    • 0024238536 scopus 로고
    • Micro-method for the measurement of carbonic anhydrase activity in cellular homogenates
    • DOI 10.1016/0003-2697(88)90391-0
    • Brion LP, Schwartz JH, Zavilowitz BJ, Schwartz GJ. Micro-method for the measurement of carbonic anhydrase activity in cellular homogenates. Anal Biochem. 1988;175(1):289-297. (Pubitemid 19007474)
    • (1988) Analytical Biochemistry , vol.175 , Issue.1 , pp. 289-297
    • Brion, L.P.1    Schwartz, J.H.2    Zavilowitz, B.J.3    Schwartz, G.J.4
  • 41
    • 51649099800 scopus 로고    scopus 로고
    • Assessing identity, phenotype, and fate of endothelial progenitor cells
    • Hirschi KK, Ingram DA, Yoder MC. Assessing identity, phenotype, and fate of endothelial progenitor cells. Arterioscler Thromb Vasc Biol. 2008;28(9):1584-1595.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , Issue.9 , pp. 1584-1595
    • Hirschi, K.K.1    Ingram, D.A.2    Yoder, M.C.3
  • 42
    • 17644433975 scopus 로고    scopus 로고
    • Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease
    • Vasa M, Fichtlscherer S, Aicher A, et al. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ Res. 2001;89(1):E1-E7.
    • (2001) Circ Res , vol.89 , Issue.1
    • Vasa, M.1    Fichtlscherer, S.2    Aicher, A.3
  • 43
    • 0035411026 scopus 로고    scopus 로고
    • The cellular physiology of carbonic anhydrases
    • Breton S. The cellular physiology of carbonic anhydrases. JOP. 2001;2(4 suppl):159-164. (Pubitemid 38963844)
    • (2001) Journal of the Pancreas , vol.2 , Issue.4 , pp. 159-164
    • Breton, S.1
  • 45
    • 42149137302 scopus 로고    scopus 로고
    • Carbonic anhydrases: An overview
    • Supuran CT. Carbonic anhydrases: an overview. Curr Pharm Des. 2008;14(7):603-614.
    • (2008) Curr Pharm des , vol.14 , Issue.7 , pp. 603-614
    • Supuran, C.T.1
  • 46
    • 58149374576 scopus 로고    scopus 로고
    • Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth
    • Zhang H, Qian DZ, Tan YS, et al. Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth. Proc Natl Acad Sci U S A. 2008;105(50):19579-19586.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.50 , pp. 19579-19586
    • Zhang, H.1    Qian, D.Z.2    Tan, Y.S.3
  • 48
    • 48949116174 scopus 로고    scopus 로고
    • In vivo enhancement of angiogenesis by adenoviral transfer of HIF-1alpha-modified endothelial progenitor cells (Ad-HIF-1alpha-modified EPC for angiogenesis)
    • Jiang M, Wang B, Wang C, et al. In vivo enhancement of angiogenesis by adenoviral transfer of HIF-1alpha-modified endothelial progenitor cells (Ad-HIF-1alpha-modified EPC for angiogenesis). Int J Biochem Cell Biol. 2008;40(10):2284-2295.
    • (2008) Int J Biochem Cell Biol , vol.40 , Issue.10 , pp. 2284-2295
    • Jiang, M.1    Wang, B.2    Wang, C.3
  • 49
    • 84928585060 scopus 로고    scopus 로고
    • Quality of life in patients with no-option critical limb ischemia underlines the need for new effective treatment
    • Sprengers RW, Teraa M, Moll FL, de Wit GA, van der Graaf Y, Verhaar MC. Quality of life in patients with no-option critical limb ischemia underlines the need for new effective treatment. J Vasc Surg. 2010;52(4):843-849.
    • (2010) J Vasc Surg , vol.52 , Issue.4 , pp. 843-849
    • Sprengers, R.W.1    Teraa, M.2    Moll, F.L.3    De Wit, G.A.4    Van Der Graaf, Y.5    Verhaar, M.C.6
  • 50
    • 33947727879 scopus 로고    scopus 로고
    • Use of a constitutively active hypoxia-inducible factor-1α transgene as a therapeutic strategy in no-option critical limb ischemia patients: Phase I dose-escalation experience
    • DOI 10.1161/CIRCULATIONAHA.106.607994
    • Rajagopalan S, Olin J, Deitcher S, et al. Use of a constitutively active hypoxia-inducible factor-1alpha transgene as a therapeutic strategy in nooption critical limb ischemia patients: phase I dose-escalation experience. Circulation. 2007;115(10):1234-1243. (Pubitemid 46594767)
    • (2007) Circulation , vol.115 , Issue.10 , pp. 1234-1243
    • Rajagopalan, S.1    Olin, J.2    Deitcher, S.3    Pieczek, A.4    Laird, J.5    Grossman, P.M.6    Goldman, C.K.7    McEllin, K.8    Kelly, R.9    Chronos, N.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.