Impaired Ca2+-handling in HIF-1α+/- mice as a consequence of pressure overload

Pflugers Archiv European Journal of Physiology

Volumn 459, Issue 4, 2010, Pages 569-577

  Silter, Monique ^a   Kögler, Harald ^a   Zieseniss, Anke ^a   Wilting, Jörg ^a   Schäfer, Katrin ^a   Toischer, Karl ^a   Rokita, Adam G ^a   Breves, Gerhard ^b   Maier, Lars S ^a   Katschinski, Dörthe M ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

Author keywords

Cardiac hypertrophy; Heart failure; Hypoxia; Hypoxia inducible factor; Transverse aortic constriction

Indexed keywords

CALCIUM ION; HYPOXIA INDUCIBLE FACTOR 1ALPHA; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; DISEASE SEVERITY; EXCITATION CONTRACTION COUPLING; FEMALE; HEART BLOOD VESSEL; HEART FAILURE; HEART LEFT VENTRICLE HYPERTROPHY; HEART LEFT VENTRICLE MASS; HEART LEFT VENTRICLE OVERLOAD; HEART LEFT VENTRICLE SIZE; HEART LEFT VENTRICLE WALL; HEART LEFT VENTRICULAR END DIASTOLIC DIAMETER; HEART LEFT VENTRICULAR ENDSYSTOLIC DIAMETER; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE SEPTUM; HEART WEIGHT; HUMAN; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SARCOPLASMIC RETICULUM; TRANSVERSE AORTA CONSTRICTION;

ANIMALS; BLOOD PRESSURE; CALCIUM; CORONARY VESSELS; FEMALE; HEART; HYPERTROPHY, LEFT VENTRICULAR; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; MICE; MICE, TRANSGENIC; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 77950928632     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-009-0748-x     Document Type: Article

References (38)

1. Baranova O, Miranda LF, Pichiule P, Dragatsis I, Johnson RS, Chavez JC (2007) Neuron-specific inactivation of the hypoxia inducible factor-1α increases brain, injury in a mouse model of transient focal cerebral ischemia. J Neurosci 27:6320-6332
2. Bernhardt WM et al (2006) Preconditional activation of hypoxiainducible factors ameliorates ischemic acute renal failure. J Am Soc Nephrol. 17:1970-1978
3. Bernhardt WM, Warnecke C, Willam C, Tanaka T, Wiesener MS, Eckardt KU (2007) Organ protection by hypoxia and hypoxiainducible factors. Methods Enzymol 435:221-245
4. Cai Z, Zhong H, Bosch-Marce M, Fox-Talbot K, Wang L, Wei C, Trush MA, Semenza GL (2008) Complete loss of ischaemic preconditioning-induced cardioprotection in mice with, partial deficiency of HIF-1α. Cardiovasc Res 77:463-470
5. Eckle T, Kohler D, Lehmann R, E1 Kasmi K, Eltzschig HK (2008) Hypoxia-inducible factor-1 is central to cardioprotection: a new paradigm for ischemic preconditioning. Circulation 118:166-175
6. Fraisl P, Aragones J, Carmeliet P (2009) Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease. Nat Rev Drug Discov 8:139-152
7. Hill P, Shukla D, Tran MG, Aragones J, Cook HT, Carmeliet P, Maxwell PH (2008) Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury. J Am Soc Nephrol 19:39-46
8. Hlatky MA et al (2007) Polymorphisms in hypoxia inducible factor 1 and the initial clinical presentation of coronary disease. Am Heart J 154:1035-1042
9. Huang M et al (2008) Short hairpin RNA interference therapy for ischemic heart disease. Circulation 118:S226-S233
10. Huang Y, Hickey RP, Yeh JL, Liu D, Dadak A, Young LH, Johnson RS, Giordano FJ (2004) Cardiac myocyte-specific HIF-1α deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart. Faseb J 18:1138-1140
11. 2 sensing. Science 292:464-468
12. 2-regulated prolyl hydroxylation. Science 292:468-472
13. Jiang Y et al (2007) Dietary copper supplementation reverses hypertrophic cardiomyopathy induced by chronic pressure overload in mice. J Exp Med 204:657-666
14. Kaelin WG Jr, Ratcliffe PJ (2008) Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell 30:393-402
15. Katschinski DM (2009) In vivo functions of the prolyl-4hydroxylase domain oxygen sensors: direct route to the treatment of anaemia and the protection of ischaemic tissues. Acta Physiol (Oxf) 195:407-414
16. Kido M, Du L, Sullivan CC, Li X, Deutsch R, Jamieson SW, Thistlethwaite PA (2005) Hypoxia-inducible factor 1α reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse. J Am. Coll Cardiol 46:2116-2124
17. Kissling G (1992) Mechanical determinants of myocardial, oxygen consumption with special reference to external, work and efficiency. Cardiovasc Res 26:886-892
18. Krishnan J, Ahuja P, Bodenmann S, Knapik D, Perriard E, Krek W, Perriard JC (2008) Essential role of developmentally activated hypoxia-inducible factor 1α for cardiac morphogenesis and function. Circ Res 103:1139-1146
19. Krishnan J et al (2009) Activation of a HIF1α-PPARγ axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy. Cell Metab 9:512-524
20. Lehnart SE, Maier LS, Hasenfuss G (2009) Abnormalities of calcium metabolism and myocardial contractility depression, in the failing heart Heart Fail Rev. doi: 10.1007/s10741-009-91.46-x
21. Liu H, Fisher SA (2008) .Hypoxia-inducible transcription factor1α triggers an autocrine survival pathway during embryonic cardiac outflow tract remodeling. Circ Res 102:1331-1339
22. Loor G, Schumacker PT (2008) Role of hypoxia-inducible factor in cell survival during myocardial, ischemia-reperfusion, Cell. Death Differ 15:686-690
23. 2+ release. Circ Res 92:904-911
24. Marti HH (2005) Angiogenesis-a self-adapting principle in. hypoxia. Exs 94:163-180
25. 2 levels. J Cell Sci 116:3041-3049
26. Maxwell PH et al (1999) The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399:271-275
27. Neumann AK, Yang J, Biju MP, Joseph. SK, Johnson RS, Haase VH, Freedman BD, Turka LA (2005) Hypoxia inducible factor 1 α regulates T cell, receptor signal transduction. Proc Natl Acad Sci USA 102:17071-17076
28. Resar JR et al (2005) Hypoxia-inducible factor 1α polymorphism and coronary collaterals in patients with ischemic heart disease. Chest 128:787-791
29. 29. Robinson A, Keely S, Karhausen J, Gerich ME, Furuta GT, Colgan SP (2008) Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition. Gastroenterology 134:145-155 (Pubitemid 350309309)
30. Ryan HE, Lo J, Johnson RS (1998) HIF-1α is required for solid tumor formation and embryonic vascularization. EMBO J 17:3005-3015
31. Sano M et al (2007) p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload. Nature 446:444-448
32. 32. Semenza GL (2004) O2-regulated gene expression: transcriptional control of cardiorespiratory physiology by HIF-1. J Appl Physiol 96:1173-1177 (Pubitemid 38248698)
33. Semenza GL (2006) Regulation of physiological responses to continuous and intermittent hypoxia by hypoxia-inducible factor 1. Exp Physiol 91:803-806
34. Siddiq A et al (2005) Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system. J Biol Chem 280:41732-41743
35. 35. Tirziu D et al (2007) Myocardial hypertrophy in the absence of external stimuli is induced by angiogenesis in mice. J Clin. Invest 117:3188-3197 (Pubitemid 350096977)
36. Wenger RH, Stiehl DP, Camenisch G (2005) Integration of oxygen signaling at the consensus HRE. Sci STKE 2005:rel2
37. Witt H et al (2008) Sex-specific pathways in early cardiac response to pressure overload in mice. J Mol. Med 86:1013-1024
38. Yu AY et al. (1999) Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α. J Clin Invest 103:691-696