메뉴 건너뛰기




Volumn , Issue , 2008, Pages 43-59

Establishing Orphan Nuclear Receptors PXR and CAR as Xenobiotic Receptors

Author keywords

Mammalian nuclear receptors; Orphan nuclear receptors xenobiotic receptors; Orphan nuclear receptors PXR and CAR

Indexed keywords


EID: 84884593899     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470409107.ch2     Document Type: Chapter
Times cited : (3)

References (87)
  • 1
    • 33644877640 scopus 로고    scopus 로고
    • An interactive course in nuclear receptor signaling: concepts and models
    • tr22
    • McKenna, N. J. and O'Malley, B. W. (2005) An interactive course in nuclear receptor signaling: concepts and models. Sci. STKE, 229, tr22.
    • (2005) Sci. STKE , pp. 229
    • McKenna, N.J.1    O'Malley, B.W.2
  • 2
    • 0032532721 scopus 로고    scopus 로고
    • Orphan nuclear receptors-new ligands and new possibilities
    • Blumberg, B. and Evans, R. M. (1998) Orphan nuclear receptors-new ligands and new possibilities. Genes Dev. 12, 3149-3155.
    • (1998) Genes Dev , vol.12 , pp. 3149-3155
    • Blumberg, B.1    Evans, R.M.2
  • 5
    • 0022653964 scopus 로고
    • Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A
    • Green, S., Walter, P., Kumar, V., Krust, A., Bornert, J. M., Argos, P., and Chambon, P. (1986) Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature 320, 134-139.
    • (1986) Nature , vol.320 , pp. 134-139
    • Green, S.1    Walter, P.2    Kumar, V.3    Krust, A.4    Bornert, J.M.5    Argos, P.6    Chambon, P.7
  • 8
    • 0023483399 scopus 로고
    • A human retinoic acid receptor which belongs to the family of nuclear receptors
    • Petkovich, M., Brand, N. J., Krust, A., and Chambon, P. (1987) A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature 330, 444-450.
    • (1987) Nature , vol.330 , pp. 444-450
    • Petkovich, M.1    Brand, N.J.2    Krust, A.3    Chambon, P.4
  • 9
    • 0023134513 scopus 로고
    • Molecular cloning of complementary DNA encoding the avian receptor for vitamin D
    • McDonnell, D. P., Mangelsdorf, D. J., Pike, J. W., Haussler, M. R., and O'Malley, B. W. (1987) Molecular cloning of complementary DNA encoding the avian receptor for vitamin D. Science 235, 1214-1217.
    • (1987) Science , vol.235 , pp. 1214-1217
    • McDonnell, D.P.1    Mangelsdorf, D.J.2    Pike, J.W.3    Haussler, M.R.4    O'Malley, B.W.5
  • 10
    • 0023221667 scopus 로고
    • Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor
    • Arriza, J. L., Weinberger, C., Cerelli, G., Glaser, T. M., Handelin, B. L., Housman, D. E., and Evans, R. M. (1987) Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. Science 237, 268-275.
    • (1987) Science , vol.237 , pp. 268-275
    • Arriza, J.L.1    Weinberger, C.2    Cerelli, G.3    Glaser, T.M.4    Handelin, B.L.5    Housman, D.E.6    Evans, R.M.7
  • 11
    • 0023910355 scopus 로고
    • Cloning of human androgen receptor complementary DNA and localization to the X chromosome
    • Lubahn, D. B., Joseph, D. R., Sullivan, P. M., Willard, H. F., French, F. S., and Wilson, E. M. (1988) Cloning of human androgen receptor complementary DNA and localization to the X chromosome. Science 240, 327-330.
    • (1988) Science , vol.240 , pp. 327-330
    • Lubahn, D.B.1    Joseph, D.R.2    Sullivan, P.M.3    Willard, H.F.4    French, F.S.5    Wilson, E.M.6
  • 12
    • 0023857147 scopus 로고
    • Identification of a new class of steroid hormone receptors
    • Giguere, V., Yang, N., Segui, P., and Evans, R. M. (1988) Identification of a new class of steroid hormone receptors. Nature 331, 91-94.
    • (1988) Nature , vol.331 , pp. 91-94
    • Giguere, V.1    Yang, N.2    Segui, P.3    Evans, R.M.4
  • 13
    • 0035976638 scopus 로고    scopus 로고
    • Nuclear receptors and lipid physiology: opening the X-files
    • Chawla, A., Repa, J. J., Evans, R. M., and Mangelsdorf, D. J. (2001) Nuclear receptors and lipid physiology: opening the X-files. Science 294, 1866-1870.
    • (2001) Science , vol.294 , pp. 1866-1870
    • Chawla, A.1    Repa, J.J.2    Evans, R.M.3    Mangelsdorf, D.J.4
  • 14
    • 0033199499 scopus 로고    scopus 로고
    • P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR
    • Waxman, D. J. (1999) P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR. Arch. Biochem. Biophys. 369, 11-23.
    • (1999) Arch. Biochem. Biophys. , vol.369 , pp. 11-23
    • Waxman, D.J.1
  • 15
    • 0035851148 scopus 로고    scopus 로고
    • Orphan nuclear receptors: the exotics of xenobiotics
    • Xie, W. and Evans, R. M. (2001) Orphan nuclear receptors: the exotics of xenobiotics. J. Biol. Chem. 276, 37739-37742.
    • (2001) J. Biol. Chem. , vol.276 , pp. 37739-37742
    • Xie, W.1    Evans, R.M.2
  • 16
    • 84986674938 scopus 로고
    • Hormones and resistance
    • Selye, H. (1971) Hormones and resistance. J. Pharm. Sci. 60, 1-28.
    • (1971) J. Pharm. Sci. , vol.60 , pp. 1-28
    • Selye, H.1
  • 17
    • 0026520777 scopus 로고
    • Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes
    • Burger, H. J., Schuetz, J. D., Schuetz, E. G., and Guzelian, P. S. (1992) Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes. Proc. Natl Acad. Sci. USA 89, 2145-2149.
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 2145-2149
    • Burger, H.J.1    Schuetz, J.D.2    Schuetz, E.G.3    Guzelian, P.S.4
  • 18
    • 0022968060 scopus 로고
    • Pregnenolone 16 alpha-carbonitrileinducible P-450 gene family: gene conversion and differential regulation
    • Gonzalez, F. J., Song, B. J., and Hardwick, J. P. (1986) Pregnenolone 16 alpha-carbonitrileinducible P-450 gene family: gene conversion and differential regulation. Mol. Cell Biol. 6, 2969-2976.
    • (1986) Mol. Cell Biol. , vol.6 , pp. 2969-2976
    • Gonzalez, F.J.1    Song, B.J.2    Hardwick, J.P.3
  • 20
  • 21
    • 0347135593 scopus 로고    scopus 로고
    • Biological function and mode of action of nuclear xenobiotic receptors
    • Sonoda, J. and Evans, R. M. (2003) Biological function and mode of action of nuclear xenobiotic receptors. Pure Appl. Chem. 75, 1733-1742.
    • (2003) Pure Appl. Chem. , vol.75 , pp. 1733-1742
    • Sonoda, J.1    Evans, R.M.2
  • 22
    • 30044438390 scopus 로고    scopus 로고
    • Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT)
    • Johnson, D. R., Li, C. W., Chen, L. Y., Ghosh, J. C., and Chen, J. D. (2006) Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT). Mol. Pharmacol. 69, 99-108.
    • (2006) Mol. Pharmacol. , vol.69 , pp. 99-108
    • Johnson, D.R.1    Li, C.W.2    Chen, L.Y.3    Ghosh, J.C.4    Chen, J.D.5
  • 23
    • 0035038919 scopus 로고    scopus 로고
    • The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
    • Synold, T. W., Dussault, I., and Forman, B. M. (2001) The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat. Med. 7, 584-590.
    • (2001) Nat. Med. , vol.7 , pp. 584-590
    • Synold, T.W.1    Dussault, I.2    Forman, B.M.3
  • 27
    • 0034782509 scopus 로고    scopus 로고
    • Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor
    • Staudinger, J., Liu, Y., Madan, A., Habeebu, S., and Klaassen, C. D. (2001) Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor. Drug Metab. Dispos. 29, 1467-1472.
    • (2001) Drug Metab. Dispos. , vol.29 , pp. 1467-1472
    • Staudinger, J.1    Liu, Y.2    Madan, A.3    Habeebu, S.4    Klaassen, C.D.5
  • 30
    • 0026290294 scopus 로고
    • Human cytochromes P450: evolution, catalytic activities and interindividual variations in expression
    • Gonzalez, F. J. and Gelboin, H. V. (1991) Human cytochromes P450: evolution, catalytic activities and interindividual variations in expression. Prog. Clin. Biol. Res. 372, 11-20.
    • (1991) Prog. Clin. Biol. Res. , vol.372 , pp. 11-20
    • Gonzalez, F.J.1    Gelboin, H.V.2
  • 31
    • 0035851148 scopus 로고    scopus 로고
    • Orphan nuclear receptors: the exotics of xenobiotics
    • Xie, W. and Evans, R. M. (2001) Orphan nuclear receptors: the exotics of xenobiotics. J. Biol. Chem. 276, 37739-37742.
    • (2001) J. Biol. Chem. , vol.276 , pp. 37739-37742
    • Xie, W.1    Evans, R.M.2
  • 32
    • 0037303706 scopus 로고    scopus 로고
    • A nuclear receptormediated xenobiotic response and its implication in drug metabolism and host protection
    • Sonoda, J., Rosenfeld, J. M., Xu, L., Evans, R.M., and Xie,W. (2003) A nuclear receptormediated xenobiotic response and its implication in drug metabolism and host protection. Curr. Drug Metab. 4, 59-72.
    • (2003) Curr. Drug Metab. , vol.4 , pp. 59-72
    • Sonoda, J.1    Rosenfeld, J.M.2    Xu, L.3    Evans, R.M.4    Xie, W.5
  • 34
    • 0034809137 scopus 로고    scopus 로고
    • Bisphenol-A, an environmental estrogen, activates the human orphan nuclear receptor, steroid and xenobiotic receptor-mediated transcription
    • Takeshita, A., Koibuchi, N., Oka, J., Taguchi, M., Shishiba, Y., and Ozawa, Y. (2001) Bisphenol-A, an environmental estrogen, activates the human orphan nuclear receptor, steroid and xenobiotic receptor-mediated transcription. Eur. J. Endocrinol. 145, 513-517.
    • (2001) Eur. J. Endocrinol. , vol.145 , pp. 513-517
    • Takeshita, A.1    Koibuchi, N.2    Oka, J.3    Taguchi, M.4    Shishiba, Y.5    Ozawa, Y.6
  • 36
    • 0037112315 scopus 로고    scopus 로고
    • PXR-dependent induction of human CYP3A4 gene expression by organochlorine pesticides
    • Coumoul, X., Diry, M., and Barouki, R. (2002) PXR-dependent induction of human CYP3A4 gene expression by organochlorine pesticides. Biochem. Pharmacol. 64, 1513-1519.
    • (2002) Biochem. Pharmacol. , vol.64 , pp. 1513-1519
    • Coumoul, X.1    Diry, M.2    Barouki, R.3
  • 37
    • 0032437889 scopus 로고    scopus 로고
    • Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element
    • Schuetz, E.G., Brimer,C., and Schuetz, J.D. (1998) Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element. Mol. Pharmacol. 54, 1113-1117.
    • (1998) Mol. Pharmacol. , vol.54 , pp. 1113-1117
    • Schuetz, E.G.1    Brimer, C.2    Schuetz, J.D.3
  • 41
    • 0033664347 scopus 로고    scopus 로고
    • Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: consequences on cytochrome P450 gene regulation
    • Pascussi, J. M., Gerbal-Chaloin, S., Fabre, J. M., Maurel, P., and Vilarem, M. J. (2000) Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: consequences on cytochrome P450 gene regulation. Mol. Pharmacol. 58, 1441-1450.
    • (2000) Mol. Pharmacol. , vol.58 , pp. 1441-1450
    • Pascussi, J.M.1    Gerbal-Chaloin, S.2    Fabre, J.M.3    Maurel, P.4    Vilarem, M.J.5
  • 42
    • 0033931266 scopus 로고    scopus 로고
    • Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators
    • Pascussi, J. M., Drocourt, L., Fabre, J. M., Maurel, P., and Vilarem, M. J. (2000) Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators. Mol. Pharmacol. 58, 361-372.
    • (2000) Mol. Pharmacol. , vol.58 , pp. 361-372
    • Pascussi, J.M.1    Drocourt, L.2    Fabre, J.M.3    Maurel, P.4    Vilarem, M.J.5
  • 43
    • 0033178677 scopus 로고    scopus 로고
    • Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation
    • Zhang, H., LeCulyse, E., Liu, L., Hu, M., Matoney, L., Zhu, W., and Yan, B. (1999) Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation. Arch. Biochem. Biophys. 368, 14-22.
    • (1999) Arch. Biochem. Biophys. , vol.368 , pp. 14-22
    • Zhang, H.1    LeCulyse, E.2    Liu, L.3    Hu, M.4    Matoney, L.5    Zhu, W.6    Yan, B.7
  • 44
    • 0038482452 scopus 로고    scopus 로고
    • Role of the hepatocyte nuclear factor 4alpha in control of the pregnane X receptor during fetal liver development
    • Kamiya, A., Inoue, Y., and Gonzalez, F. J. (2003) Role of the hepatocyte nuclear factor 4alpha in control of the pregnane X receptor during fetal liver development. Hepatology 37, 1375-1384.
    • (2003) Hepatology , vol.37 , pp. 1375-1384
    • Kamiya, A.1    Inoue, Y.2    Gonzalez, F.J.3
  • 47
    • 0031409592 scopus 로고    scopus 로고
    • Regulation of cytochromes P450 during inflammation and infection
    • Morgan, E. T. (1997) Regulation of cytochromes P450 during inflammation and infection. Drug Metab. Rev. 29, 1129-1188.
    • (1997) Drug Metab. Rev. , vol.29 , pp. 1129-1188
    • Morgan, E.T.1
  • 48
    • 0034637122 scopus 로고    scopus 로고
    • Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes
    • Pascussi, J. M., Gerbal-Chaloin, S., Pichard-Garcia, L., Daujat, M., Fabre, J. M., Maurel, P., and Vilarem, M. J. (2000) Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes. Biochem. Biophys. Res. Commun. 274, 707-713.
    • (2000) Biochem. Biophys. Res. Commun. , vol.274 , pp. 707-713
    • Pascussi, J.M.1    Gerbal-Chaloin, S.2    Pichard-Garcia, L.3    Daujat, M.4    Fabre, J.M.5    Maurel, P.6    Vilarem, M.J.7
  • 49
    • 0036296149 scopus 로고    scopus 로고
    • Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response
    • Beigneux, A. P., Moser, A. H., Shigenaga, J. K., Grunfeld, C., and Feingold, K. R. (2002) Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response. Biochem. Biophys. Res. Commun. 293, 145-149.
    • (2002) Biochem. Biophys. Res. Commun. , vol.293 , pp. 145-149
    • Beigneux, A.P.1    Moser, A.H.2    Shigenaga, J.K.3    Grunfeld, C.4    Feingold, K.R.5
  • 50
    • 33746675685 scopus 로고    scopus 로고
    • Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation
    • Zhou, C., Tabb, M. M., Nelson, E. L., Grun, F., Verma, S., Sadatrafiei, A., Lin, M.,Mallick, S., Forman, B. M., Thummel, K. E., et al. (2006) Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation. J. Clin. Invest. 116, 2280-2289.
    • (2006) J. Clin. Invest. , vol.116 , pp. 2280-2289
    • Zhou, C.1    Tabb, M.M.2    Nelson, E.L.3    Grun, F.4    Verma, S.5    Sadatrafiei, A.6    Lin, M.7    Mallick, S.8    Forman, B.M.9    Thummel, K.E.10
  • 52
    • 0036192731 scopus 로고    scopus 로고
    • Orphan nuclear receptor binding site in the human inducible nitric oxide synthase promoter mediates responsiveness to steroid and xenobiotic ligands
    • Toell, A., Kroncke, K. D., Kleinert, H., and Carlberg, C. (2002) Orphan nuclear receptor binding site in the human inducible nitric oxide synthase promoter mediates responsiveness to steroid and xenobiotic ligands. J. Cell Biochem. 85, 72-82.
    • (2002) J. Cell Biochem. , vol.85 , pp. 72-82
    • Toell, A.1    Kroncke, K.D.2    Kleinert, H.3    Carlberg, C.4
  • 53
    • 33744948052 scopus 로고    scopus 로고
    • A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway
    • Zhou, J., Zhai, Y., Mu, Y., Gong, H., Uppal, H., Toma, D., Ren, S., Evans, R. M., and Xie, W. (2006) A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway. J. Biol. Chem. 281, 15013-15020.
    • (2006) J. Biol. Chem. , vol.281 , pp. 15013-15020
    • Zhou, J.1    Zhai, Y.2    Mu, Y.3    Gong, H.4    Uppal, H.5    Toma, D.6    Ren, S.7    Evans, R.M.8    Xie, W.9
  • 54
    • 33845970888 scopus 로고    scopus 로고
    • Activation of pregnane X receptor disrupts glucocorticoid and mineralocorticoid homeostasis
    • Zhai, Y., Pai, H. V., Zhou, J., Amico, J. A., Vollmer, R. R., and Xie, W. (2007) Activation of pregnane X receptor disrupts glucocorticoid and mineralocorticoid homeostasis. Mol. Endocrinol. 21, 138-147.
    • (2007) Mol. Endocrinol. , vol.21 , pp. 138-147
    • Zhai, Y.1    Pai, H.V.2    Zhou, J.3    Amico, J.A.4    Vollmer, R.R.5    Xie, W.6
  • 55
    • 0031682988 scopus 로고    scopus 로고
    • The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene
    • Honkakoski, P., Zelko, I., Sueyoshi, T., andNegishi,M. (1998) The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene. Mol. Cell Biol. 18, 5652-5658.
    • (1998) Mol. Cell Biol. , vol.18 , pp. 5652-5658
    • Honkakoski, P.1    Zelko, I.2    Sueyoshi, T.3    Negishi, M.4
  • 56
    • 0035038008 scopus 로고    scopus 로고
    • Phenobarbital response elements of cytochrome P450 genes and nuclear receptors
    • Sueyoshi, T. and Negishi, M. (2001) Phenobarbital response elements of cytochrome P450 genes and nuclear receptors. Annu. Rev. Pharmacol. Toxicol. 41, 123-143.
    • (2001) Annu. Rev. Pharmacol. Toxicol. , vol.41 , pp. 123-143
    • Sueyoshi, T.1    Negishi, M.2
  • 58
    • 0033525886 scopus 로고    scopus 로고
    • The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene
    • Sueyoshi, T., Kawamoto, T., Zelko, I., Honkakoski, P., and Negishi, M. (1999) The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene. J. Biol. Chem. 274, 6043-6046.
    • (1999) J. Biol. Chem. , vol.274 , pp. 6043-6046
    • Sueyoshi, T.1    Kawamoto, T.2    Zelko, I.3    Honkakoski, P.4    Negishi, M.5
  • 59
    • 0034687397 scopus 로고    scopus 로고
    • The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism
    • Wei, P., Zhang, J., Egan-Hafley, M., Liang, S., and Moore, D. D. (2000) The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism. Nature 407, 920-923.
    • (2000) Nature , vol.407 , pp. 920-923
    • Wei, P.1    Zhang, J.2    Egan-Hafley, M.3    Liang, S.4    Moore, D.D.5
  • 60
    • 0037064177 scopus 로고    scopus 로고
    • Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR
    • Zhang, J., Huang, W., Chua, S. S., Wei, P., and Moore, D. D. (2002) Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR. Science 298, 422-424.
    • (2002) Science , vol.298 , pp. 422-424
    • Zhang, J.1    Huang, W.2    Chua, S.S.3    Wei, P.4    Moore, D.D.5
  • 62
    • 5044237671 scopus 로고    scopus 로고
    • Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR
    • Huang, W., Zhang, J., Wei, P., Schrader, W. T., and Moore, D. D. (2004) Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR. Mol. Endocrinol. 18, 2402-2408.
    • (2004) Mol. Endocrinol. , vol.18 , pp. 2402-2408
    • Huang, W.1    Zhang, J.2    Wei, P.3    Schrader, W.T.4    Moore, D.D.5
  • 63
    • 23944487083 scopus 로고    scopus 로고
    • Di-n-butyl phthalate activates constitutive androstane receptor and pregnane X receptor and enhances the expression of steroidmetabolizing enzymes in the liver of rat fetuses
    • Wyde, M. E., Kirwan, S. E., Zhang, F., Laughter, A., Hoffman, H. B., Bartolucci-Page, E., Gaido, K. W., Yan, B., and You, L. (2005) Di-n-butyl phthalate activates constitutive 58 ESTABLISHING ORPHAN NUCLEAR RECEPTORS PXR AND CAR androstane receptor and pregnane X receptor and enhances the expression of steroidmetabolizing enzymes in the liver of rat fetuses. Toxicol. Sci. 86, 281-290.
    • (2005) Toxicol. Sci. , vol.86 , pp. 281-290
    • Wyde, M.E.1    Kirwan, S.E.2    Zhang, F.3    Laughter, A.4    Hoffman, H.B.5    Bartolucci-Page, E.6    Gaido, K.W.7    Yan, B.8    You, L.9
  • 66
    • 0033999734 scopus 로고    scopus 로고
    • The xenobiotic compound 1,4-bis[2-(3 5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR
    • Tzameli, I., Pissios, P., Schuetz, E. G., andMoore, D. D. (2000) The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR. Mol. Cell Biol. 20, 2951-2958.
    • (2000) Mol. Cell Biol. , vol.20 , pp. 2951-2958
    • Tzameli, I.1    Pissios, P.2    Schuetz, E.G.3    Moore, D.D.4
  • 67
    • 0037135532 scopus 로고    scopus 로고
    • Glucocorticoid receptor-interacting protein 1 mediates ligand-independent nuclear translocation and activation of constitutive androstane receptor in vivo
    • Min, G., Kemper, J. K., and Kemper, B. (2002) Glucocorticoid receptor-interacting protein 1 mediates ligand-independent nuclear translocation and activation of constitutive androstane receptor in vivo. J. Biol. Chem. 277, 26356-26363.
    • (2002) J. Biol. Chem. , vol.277 , pp. 26356-26363
    • Min, G.1    Kemper, J.K.2    Kemper, B.3
  • 68
    • 22444448890 scopus 로고    scopus 로고
    • Characterization of activating signal cointegrator-2 as a novel transcriptional coactivator of the xenobiotic nuclear receptor constitutive androstane receptor
    • Choi, E., Lee, S., Yeom, S. Y., Kim, G. H., Lee, J. W., and Kim, S. W. (2005) Characterization of activating signal cointegrator-2 as a novel transcriptional coactivator of the xenobiotic nuclear receptor constitutive androstane receptor. Mol. Endocrinol. 19, 1711-1719.
    • (2005) Mol. Endocrinol. , vol.19 , pp. 1711-1719
    • Choi, E.1    Lee, S.2    Yeom, S.Y.3    Kim, G.H.4    Lee, J.W.5    Kim, S.W.6
  • 69
    • 0038514189 scopus 로고    scopus 로고
    • Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferatoractivated receptor gamma coactivator-1 alpha Apossible link between xenobiotic response and nutritional state
    • Shiraki, T., Sakai, N., Kanaya, E., and Jingami, H. (2003) Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferatoractivated receptor gamma coactivator-1 alpha.Apossible link between xenobiotic response and nutritional state. J. Biol. Chem. 278, 11344-11350.
    • (2003) J. Biol. Chem. , vol.278 , pp. 11344-11350
    • Shiraki, T.1    Sakai, N.2    Kanaya, E.3    Jingami, H.4
  • 70
    • 0035076197 scopus 로고    scopus 로고
    • The peptide near the C terminus regulates receptor CAR nuclear translocation induced by xenochemicals in mouse liver
    • Zelko, I., Sueyoshi, T., Kawamoto, T.,Moore, R., and Negishi, M. (2001) The peptide near the C terminus regulates receptor CAR nuclear translocation induced by xenochemicals in mouse liver. Mol. Cell Biol. 21, 2838-2846.
    • (2001) Mol. Cell Biol. , vol.21 , pp. 2838-2846
    • Zelko, I.1    Sueyoshi, T.2    Kawamoto, T.3    Moore, R.4    Negishi, M.5
  • 71
    • 33847024555 scopus 로고    scopus 로고
    • CAR and PXR: the xenobiotic-sensing receptors
    • Timsit, Y. E. and Negishi, M. (2007) CAR and PXR: the xenobiotic-sensing receptors. Steroids 72, 231-246.
    • (2007) Steroids , vol.72 , pp. 231-246
    • Timsit, Y.E.1    Negishi, M.2
  • 72
    • 0032766430 scopus 로고    scopus 로고
    • Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene
    • Kawamoto, T., Sueyoshi, T., Zelko, I., Moore, R., Washburn, K., and Negishi, M. (1999) Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene. Mol. Cell Biol. 19, 6318-6322.
    • (1999) Mol. Cell Biol. , vol.19 , pp. 6318-6322
    • Kawamoto, T.1    Sueyoshi, T.2    Zelko, I.3    Moore, R.4    Washburn, K.5    Negishi, M.6
  • 73
    • 0142210183 scopus 로고    scopus 로고
    • Cytoplasmic accumulation of the nuclear receptor CAR by a tetratricopeptide repeat protein in HepG2 cells
    • Kobayashi, K., Sueyoshi, T., Inoue, K., Moore, R., and Negishi, M. (2003) Cytoplasmic accumulation of the nuclear receptor CAR by a tetratricopeptide repeat protein in HepG2 cells. Mol. Pharmacol. 64, 1069-1075.
    • (2003) Mol. Pharmacol. , vol.64 , pp. 1069-1075
    • Kobayashi, K.1    Sueyoshi, T.2    Inoue, K.3    Moore, R.4    Negishi, M.5
  • 74
    • 28844498056 scopus 로고    scopus 로고
    • Localization of the nuclear receptor CAR at the cell membrane of mouse liver
    • Koike, C., Moore, R., and Negishi, M. (2005) Localization of the nuclear receptor CAR at the cell membrane of mouse liver. FEBS Lett. 579, 6733-6736.
    • (2005) FEBS Lett , vol.579 , pp. 6733-6736
    • Koike, C.1    Moore, R.2    Negishi, M.3
  • 75
    • 8344219885 scopus 로고    scopus 로고
    • Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver
    • Squires, E. J., Sueyoshi, T., and Negishi, M. (2004) Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver. J. Biol. Chem. 279, 49307-49314.
    • (2004) J. Biol. Chem. , vol.279 , pp. 49307-49314
    • Squires, E.J.1    Sueyoshi, T.2    Negishi, M.3
  • 76
    • 33747169939 scopus 로고    scopus 로고
    • Cohesin protein SMC1 represses the nuclear receptor CAR-mediated synergistic activation of a human P450 gene by xenobiotics
    • Inoue,K., Borchers, C.H., andNegishi,M. (2006) Cohesin protein SMC1 represses the nuclear receptor CAR-mediated synergistic activation of a human P450 gene by xenobiotics. Biochem. J. 398, 125-133.
    • (2006) Biochem. J. , vol.398 , pp. 125-133
    • Inoue, K.1    Borchers, C.H.2    Negishi, M.3
  • 77
    • 33846502281 scopus 로고    scopus 로고
    • In the regulation of cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of AMPactivated protein kinase
    • Blattler, S. M., Rencurel, F., Kaufmann, M. R., and Meyer, U. A. (2007) In the regulation of cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of AMPactivated protein kinase. Proc. Natl Acad. Sci. USA 104, 1045-1050.
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 1045-1050
    • Blattler, S.M.1    Rencurel, F.2    Kaufmann, M.R.3    Meyer, U.A.4
  • 78
    • 15644384598 scopus 로고    scopus 로고
    • AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line
    • Rencurel, F., Stenhouse, A., Hawley, S. A., Friedberg, T., Hardie, D. G., Sutherland, C., and Wolf, C. R. (2005) AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line. J. Biol. Chem. 280, 4367-4373.
    • (2005) J. Biol. Chem. , vol.280 , pp. 4367-4373
    • Rencurel, F.1    Stenhouse, A.2    Hawley, S.A.3    Friedberg, T.4    Hardie, D.G.5    Sutherland, C.6    Wolf, C.R.7
  • 79
    • 33846886331 scopus 로고    scopus 로고
    • A physiological role of AMP-activated protein kinase in phenobarbital-mediated constitutive androstane receptor activation and CYP2B induction
    • Shindo, S., Numazawa, S., and Yoshida, T. (2007) A physiological role of AMP-activated protein kinase in phenobarbital-mediated constitutive androstane receptor activation and CYP2B induction. Biochem. J. 401, 735-741.
    • (2007) Biochem. J. , vol.401 , pp. 735-741
    • Shindo, S.1    Numazawa, S.2    Yoshida, T.3
  • 81
    • 0037169551 scopus 로고    scopus 로고
    • Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor
    • Kast, H. R., Goodwin, B., Tarr, P. T., Jones, S. A., Anisfeld, A. M., Stoltz, C.M., Tontonoz, P., Kliewer, S., Willson, T. M., and Edwards, P. A. (2002) Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J. Biol. Chem. 277, 2908-2915.
    • (2002) J. Biol. Chem. , vol.277 , pp. 2908-2915
    • Kast, H.R.1    Goodwin, B.2    Tarr, P.T.3    Jones, S.A.4    Anisfeld, A.M.5    Stoltz, C.M.6    Tontonoz, P.7    Kliewer, S.8    Willson, T.M.9    Edwards, P.A.10
  • 83
    • 0035201366 scopus 로고    scopus 로고
    • Rifampin is a selective, pleiotropic inducer of drug metabolism genes in human hepatocytes: studies with cDNA and oligonucleotide expression arrays
    • Rae, J. M., Johnson, M. D., Lippman, M. E., and Flockhart, D. A. (2001) Rifampin is a selective, pleiotropic inducer of drug metabolism genes in human hepatocytes: studies with cDNA and oligonucleotide expression arrays. J. Pharmacol. Exp. Ther. 299, 849-857.
    • (2001) J. Pharmacol. Exp. Ther. , vol.299 , pp. 849-857
    • Rae, J.M.1    Johnson, M.D.2    Lippman, M.E.3    Flockhart, D.A.4
  • 84
    • 0036765785 scopus 로고    scopus 로고
    • Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification
    • Maglich, J. M., Stoltz, C.M., Goodwin, B., Hawkins-Brown, D.,Moore, J. T., and Kliewer, S. A. (2002) Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification. Mol. Pharmacol. 62, 638-646.
    • (2002) Mol. Pharmacol. , vol.62 , pp. 638-646
    • Maglich, J.M.1    Stoltz, C.M.2    Goodwin, B.3    Hawkins-Brown, D.4    Moore, J.T.5    Kliewer, S.A.6
  • 87
    • 0035029401 scopus 로고    scopus 로고
    • The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR
    • Sugatani, J., Kojima, H., Ueda, A., Kakizaki, S., Yoshinari, K., Gong, Q. H., Owens, I. S., Negishi, M., and Sueyoshi, T. (2001) The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR. Hepatology 33, 1232-1238.
    • (2001) Hepatology , vol.33 , pp. 1232-1238
    • Sugatani, J.1    Kojima, H.2    Ueda, A.3    Kakizaki, S.4    Yoshinari, K.5    Gong, Q.H.6    Owens, I.S.7    Negishi, M.8    Sueyoshi, T.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.