-
1
-
-
33644877640
-
An interactive course in nuclear receptor signaling: concepts and models
-
tr22
-
McKenna, N. J. and O'Malley, B. W. (2005) An interactive course in nuclear receptor signaling: concepts and models. Sci. STKE, 229, tr22.
-
(2005)
Sci. STKE
, pp. 229
-
-
McKenna, N.J.1
O'Malley, B.W.2
-
2
-
-
0032532721
-
Orphan nuclear receptors-new ligands and new possibilities
-
Blumberg, B. and Evans, R. M. (1998) Orphan nuclear receptors-new ligands and new possibilities. Genes Dev. 12, 3149-3155.
-
(1998)
Genes Dev
, vol.12
, pp. 3149-3155
-
-
Blumberg, B.1
Evans, R.M.2
-
3
-
-
0012473279
-
The nuclear receptor superfamily: the second decade
-
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schutz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) The nuclear receptor superfamily: the second decade. Cell 83, 835-839.
-
(1995)
Cell
, vol.83
, pp. 835-839
-
-
Mangelsdorf, D.J.1
Thummel, C.2
Beato, M.3
Herrlich, P.4
Schutz, G.5
Umesono, K.6
Blumberg, B.7
Kastner, P.8
Mark, M.9
Chambon, P.10
-
4
-
-
0021836027
-
Identification of human glucocorticoid receptor complementary DNA clones by epitope selection
-
Weinberger, C., Hollenberg, S. M., Ong, E. S., Harmon, J. M., Brower, S. T., Cidlowski, J., Thompson, E. B., Rosenfeld, M. G., and Evans, R. M. (1985) Identification of human glucocorticoid receptor complementary DNA clones by epitope selection. Science 228, 740-742.
-
(1985)
Science
, vol.228
, pp. 740-742
-
-
Weinberger, C.1
Hollenberg, S.M.2
Ong, E.S.3
Harmon, J.M.4
Brower, S.T.5
Cidlowski, J.6
Thompson, E.B.7
Rosenfeld, M.G.8
Evans, R.M.9
-
5
-
-
0022653964
-
Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A
-
Green, S., Walter, P., Kumar, V., Krust, A., Bornert, J. M., Argos, P., and Chambon, P. (1986) Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature 320, 134-139.
-
(1986)
Nature
, vol.320
, pp. 134-139
-
-
Green, S.1
Walter, P.2
Kumar, V.3
Krust, A.4
Bornert, J.M.5
Argos, P.6
Chambon, P.7
-
6
-
-
0022487022
-
Molecular cloning of the chicken progesterone receptor
-
Conneely, O. M., Sullivan, W. P., Toft, D. O., Birnbaumer, M., Cook, R. G., Maxwell, B. L., Zarucki-Schulz, T., Greene, G. L., Schrader, W. T., and O'Malley, B. W. (1986) Molecular cloning of the chicken progesterone receptor. Science 233, 767-770.
-
(1986)
Science
, vol.233
, pp. 767-770
-
-
Conneely, O.M.1
Sullivan, W.P.2
Toft, D.O.3
Birnbaumer, M.4
Cook, R.G.5
Maxwell, B.L.6
Zarucki-Schulz, T.7
Greene, G.L.8
Schrader, W.T.9
O'Malley, B.W.10
-
7
-
-
0022998995
-
The c-erb-A gene encodes a thyroid hormone receptor
-
Weinberger, C., Thompson, C. C., Ong, E. S., Lebo, R., Gruol, D. J., and Evans, R. M. (1986) The c-erb-A gene encodes a thyroid hormone receptor. Nature 324, 641-646.
-
(1986)
Nature
, vol.324
, pp. 641-646
-
-
Weinberger, C.1
Thompson, C.C.2
Ong, E.S.3
Lebo, R.4
Gruol, D.J.5
Evans, R.M.6
-
8
-
-
0023483399
-
A human retinoic acid receptor which belongs to the family of nuclear receptors
-
Petkovich, M., Brand, N. J., Krust, A., and Chambon, P. (1987) A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature 330, 444-450.
-
(1987)
Nature
, vol.330
, pp. 444-450
-
-
Petkovich, M.1
Brand, N.J.2
Krust, A.3
Chambon, P.4
-
9
-
-
0023134513
-
Molecular cloning of complementary DNA encoding the avian receptor for vitamin D
-
McDonnell, D. P., Mangelsdorf, D. J., Pike, J. W., Haussler, M. R., and O'Malley, B. W. (1987) Molecular cloning of complementary DNA encoding the avian receptor for vitamin D. Science 235, 1214-1217.
-
(1987)
Science
, vol.235
, pp. 1214-1217
-
-
McDonnell, D.P.1
Mangelsdorf, D.J.2
Pike, J.W.3
Haussler, M.R.4
O'Malley, B.W.5
-
10
-
-
0023221667
-
Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor
-
Arriza, J. L., Weinberger, C., Cerelli, G., Glaser, T. M., Handelin, B. L., Housman, D. E., and Evans, R. M. (1987) Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. Science 237, 268-275.
-
(1987)
Science
, vol.237
, pp. 268-275
-
-
Arriza, J.L.1
Weinberger, C.2
Cerelli, G.3
Glaser, T.M.4
Handelin, B.L.5
Housman, D.E.6
Evans, R.M.7
-
11
-
-
0023910355
-
Cloning of human androgen receptor complementary DNA and localization to the X chromosome
-
Lubahn, D. B., Joseph, D. R., Sullivan, P. M., Willard, H. F., French, F. S., and Wilson, E. M. (1988) Cloning of human androgen receptor complementary DNA and localization to the X chromosome. Science 240, 327-330.
-
(1988)
Science
, vol.240
, pp. 327-330
-
-
Lubahn, D.B.1
Joseph, D.R.2
Sullivan, P.M.3
Willard, H.F.4
French, F.S.5
Wilson, E.M.6
-
12
-
-
0023857147
-
Identification of a new class of steroid hormone receptors
-
Giguere, V., Yang, N., Segui, P., and Evans, R. M. (1988) Identification of a new class of steroid hormone receptors. Nature 331, 91-94.
-
(1988)
Nature
, vol.331
, pp. 91-94
-
-
Giguere, V.1
Yang, N.2
Segui, P.3
Evans, R.M.4
-
13
-
-
0035976638
-
Nuclear receptors and lipid physiology: opening the X-files
-
Chawla, A., Repa, J. J., Evans, R. M., and Mangelsdorf, D. J. (2001) Nuclear receptors and lipid physiology: opening the X-files. Science 294, 1866-1870.
-
(2001)
Science
, vol.294
, pp. 1866-1870
-
-
Chawla, A.1
Repa, J.J.2
Evans, R.M.3
Mangelsdorf, D.J.4
-
14
-
-
0033199499
-
P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR
-
Waxman, D. J. (1999) P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR. Arch. Biochem. Biophys. 369, 11-23.
-
(1999)
Arch. Biochem. Biophys.
, vol.369
, pp. 11-23
-
-
Waxman, D.J.1
-
15
-
-
0035851148
-
Orphan nuclear receptors: the exotics of xenobiotics
-
Xie, W. and Evans, R. M. (2001) Orphan nuclear receptors: the exotics of xenobiotics. J. Biol. Chem. 276, 37739-37742.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 37739-37742
-
-
Xie, W.1
Evans, R.M.2
-
16
-
-
84986674938
-
Hormones and resistance
-
Selye, H. (1971) Hormones and resistance. J. Pharm. Sci. 60, 1-28.
-
(1971)
J. Pharm. Sci.
, vol.60
, pp. 1-28
-
-
Selye, H.1
-
17
-
-
0026520777
-
Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes
-
Burger, H. J., Schuetz, J. D., Schuetz, E. G., and Guzelian, P. S. (1992) Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes. Proc. Natl Acad. Sci. USA 89, 2145-2149.
-
(1992)
Proc. Natl Acad. Sci. USA
, vol.89
, pp. 2145-2149
-
-
Burger, H.J.1
Schuetz, J.D.2
Schuetz, E.G.3
Guzelian, P.S.4
-
18
-
-
0022968060
-
Pregnenolone 16 alpha-carbonitrileinducible P-450 gene family: gene conversion and differential regulation
-
Gonzalez, F. J., Song, B. J., and Hardwick, J. P. (1986) Pregnenolone 16 alpha-carbonitrileinducible P-450 gene family: gene conversion and differential regulation. Mol. Cell Biol. 6, 2969-2976.
-
(1986)
Mol. Cell Biol.
, vol.6
, pp. 2969-2976
-
-
Gonzalez, F.J.1
Song, B.J.2
Hardwick, J.P.3
-
19
-
-
0032498303
-
An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway
-
Kliewer, S. A., Moore, J. T., Wade, L., Staudinger, J. L., Watson, M. A., Jones, S. A., McKee, D. D., Oliver, B. B., Willson, T. M., Zetterstrom, R. H., et al. (1998) An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell 92, 73-82. REFERENCES 55
-
(1998)
Cell
, vol.92
, pp. 73-82
-
-
Kliewer, S.A.1
Moore, J.T.2
Wade, L.3
Staudinger, J.L.4
Watson, M.A.5
Jones, S.A.6
McKee, D.D.7
Oliver, B.B.8
Willson, T.M.9
Zetterstrom, R.H.10
-
20
-
-
0036171965
-
Regulation of cyp3a gene transcription by the pregnane X receptor
-
Goodwin, B., Redinbo, M. R., and Kliewer, S. A. (2002) Regulation of cyp3a gene transcription by the pregnane X receptor. Annu. Rev. Pharmacol. Toxicol. 42, 1-23.
-
(2002)
Annu. Rev. Pharmacol. Toxicol.
, vol.42
, pp. 1-23
-
-
Goodwin, B.1
Redinbo, M.R.2
Kliewer, S.A.3
-
21
-
-
0347135593
-
Biological function and mode of action of nuclear xenobiotic receptors
-
Sonoda, J. and Evans, R. M. (2003) Biological function and mode of action of nuclear xenobiotic receptors. Pure Appl. Chem. 75, 1733-1742.
-
(2003)
Pure Appl. Chem.
, vol.75
, pp. 1733-1742
-
-
Sonoda, J.1
Evans, R.M.2
-
22
-
-
30044438390
-
Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT)
-
Johnson, D. R., Li, C. W., Chen, L. Y., Ghosh, J. C., and Chen, J. D. (2006) Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT). Mol. Pharmacol. 69, 99-108.
-
(2006)
Mol. Pharmacol.
, vol.69
, pp. 99-108
-
-
Johnson, D.R.1
Li, C.W.2
Chen, L.Y.3
Ghosh, J.C.4
Chen, J.D.5
-
23
-
-
0035038919
-
The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
-
Synold, T. W., Dussault, I., and Forman, B. M. (2001) The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat. Med. 7, 584-590.
-
(2001)
Nat. Med.
, vol.7
, pp. 584-590
-
-
Synold, T.W.1
Dussault, I.2
Forman, B.M.3
-
24
-
-
0034721159
-
Humanized xenobiotic response in mice expressing nuclear receptor SXR
-
Xie, W., Barwick, J. L., Downes, M., Blumberg, B., Simon, C. M., Nelson, M. C., Neuschwander-Tetri, B. A., Brunt, E.M., Guzelian, P. S., and Evans, R. M. (2000) Humanized xenobiotic response in mice expressing nuclear receptor SXR. Nature 406, 435-439.
-
(2000)
Nature
, vol.406
, pp. 435-439
-
-
Xie, W.1
Barwick, J.L.2
Downes, M.3
Blumberg, B.4
Simon, C.M.5
Nelson, M.C.6
Neuschwander-Tetri, B.A.7
Brunt, E.M.8
Guzelian, P.S.9
Evans, R.M.10
-
25
-
-
0035853165
-
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
-
Staudinger, J. L., Goodwin, B., Jones, S. A., Hawkins-Brown, D., MacKenzie, K. I., LaTour, A., Liu, Y., Klaassen, C. D., Brown, K. K., Reinhard, J., et al. (2001) The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc. Natl Acad. Sci. USA 98, 3369-3374.
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 3369-3374
-
-
Staudinger, J.L.1
Goodwin, B.2
Jones, S.A.3
Hawkins-Brown, D.4
MacKenzie, K.I.5
LaTour, A.6
Liu, Y.7
Klaassen, C.D.8
Brown, K.K.9
Reinhard, J.10
-
26
-
-
0035853057
-
An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids
-
Xie, W., Radominska-Pandya, A., Shi, Y., Simon, C. M., Nelson, M. C., Ong, E. S., Waxman, D. J., and Evans, R. M. (2001) An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Proc. Natl Acad. Sci. USA 98, 3375-3380.
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 3375-3380
-
-
Xie, W.1
Radominska-Pandya, A.2
Shi, Y.3
Simon, C.M.4
Nelson, M.C.5
Ong, E.S.6
Waxman, D.J.7
Evans, R.M.8
-
27
-
-
0034782509
-
Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor
-
Staudinger, J., Liu, Y., Madan, A., Habeebu, S., and Klaassen, C. D. (2001) Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor. Drug Metab. Dispos. 29, 1467-1472.
-
(2001)
Drug Metab. Dispos.
, vol.29
, pp. 1467-1472
-
-
Staudinger, J.1
Liu, Y.2
Madan, A.3
Habeebu, S.4
Klaassen, C.D.5
-
28
-
-
0032532134
-
SXR, a novel steroid and xenobiotic-sensing nuclear receptor
-
Blumberg, B., Sabbagh,W., Jr., Juguilon, H., Bolado, J., Jr., van Meter, C. M., Ong, E. S., and Evans, R. M. (1998) SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes Dev. 12, 3195-3205.
-
(1998)
Genes Dev
, vol.12
, pp. 3195-3205
-
-
Blumberg, B.1
Sabbagh Jr, W.2
Juguilon, H.3
Bolado Jr, J.4
van Meter, C.M.5
Ong, E.S.6
Evans, R.M.7
-
29
-
-
13144260727
-
Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction
-
Bertilsson, G., Heidrich, J., Svensson, K., Asman, M., Jendeberg, L., Sydow-Backman, M., Ohlsson, R., Postlind, H., Blomquist, P., and Berkenstam, A. (1998) Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc. Natl Acad. Sci. USA 95, 12208-12213.
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 12208-12213
-
-
Bertilsson, G.1
Heidrich, J.2
Svensson, K.3
Asman, M.4
Jendeberg, L.5
Sydow-Backman, M.6
Ohlsson, R.7
Postlind, H.8
Blomquist, P.9
Berkenstam, A.10
-
30
-
-
0026290294
-
Human cytochromes P450: evolution, catalytic activities and interindividual variations in expression
-
Gonzalez, F. J. and Gelboin, H. V. (1991) Human cytochromes P450: evolution, catalytic activities and interindividual variations in expression. Prog. Clin. Biol. Res. 372, 11-20.
-
(1991)
Prog. Clin. Biol. Res.
, vol.372
, pp. 11-20
-
-
Gonzalez, F.J.1
Gelboin, H.V.2
-
31
-
-
0035851148
-
Orphan nuclear receptors: the exotics of xenobiotics
-
Xie, W. and Evans, R. M. (2001) Orphan nuclear receptors: the exotics of xenobiotics. J. Biol. Chem. 276, 37739-37742.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 37739-37742
-
-
Xie, W.1
Evans, R.M.2
-
32
-
-
0037303706
-
A nuclear receptormediated xenobiotic response and its implication in drug metabolism and host protection
-
Sonoda, J., Rosenfeld, J. M., Xu, L., Evans, R.M., and Xie,W. (2003) A nuclear receptormediated xenobiotic response and its implication in drug metabolism and host protection. Curr. Drug Metab. 4, 59-72.
-
(2003)
Curr. Drug Metab.
, vol.4
, pp. 59-72
-
-
Sonoda, J.1
Rosenfeld, J.M.2
Xu, L.3
Evans, R.M.4
Xie, W.5
-
33
-
-
0035933511
-
The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity
-
Watkins, R. E.,Wisely, G. B.,Moore, L. B., Collins, J. L., Lambert,M. H.,Williams, S. P., Willson, T. M., Kliewer, S. A., and Redinbo, M. R. (2001) The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity. Science 292, 2329-2333.
-
(2001)
Science
, vol.292
, pp. 2329-2333
-
-
Watkins, R.E.1
Wisely, G.B.2
Moore, L.B.3
Collins, J.L.4
Lambert, M.H.5
Williams, S.P.6
Willson, T.M.7
Kliewer, S.A.8
Redinbo, M.R.9
-
34
-
-
0034809137
-
Bisphenol-A, an environmental estrogen, activates the human orphan nuclear receptor, steroid and xenobiotic receptor-mediated transcription
-
Takeshita, A., Koibuchi, N., Oka, J., Taguchi, M., Shishiba, Y., and Ozawa, Y. (2001) Bisphenol-A, an environmental estrogen, activates the human orphan nuclear receptor, steroid and xenobiotic receptor-mediated transcription. Eur. J. Endocrinol. 145, 513-517.
-
(2001)
Eur. J. Endocrinol.
, vol.145
, pp. 513-517
-
-
Takeshita, A.1
Koibuchi, N.2
Oka, J.3
Taguchi, M.4
Shishiba, Y.5
Ozawa, Y.6
-
35
-
-
34347270605
-
The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors
-
Ricketts, M. L., Boekschoten, M. V., Kreeft, A. J., Hooiveld, G. J., Moen, C. J., Muller, M., Frants, R. R., Kasanmoentalib, S., Post, S. M., Princen, H. M., et al. (2007) The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors. Mol. Endocrinol. 21, 1603-1616. 56 ESTABLISHING ORPHAN NUCLEAR RECEPTORS PXR AND CAR
-
(2007)
Mol. Endocrinol.
, vol.21
, pp. 1603-1616
-
-
Ricketts, M.L.1
Boekschoten, M.V.2
Kreeft, A.J.3
Hooiveld, G.J.4
Moen, C.J.5
Muller, M.6
Frants, R.R.7
Kasanmoentalib, S.8
Post, S.M.9
Princen, H.M.10
-
36
-
-
0037112315
-
PXR-dependent induction of human CYP3A4 gene expression by organochlorine pesticides
-
Coumoul, X., Diry, M., and Barouki, R. (2002) PXR-dependent induction of human CYP3A4 gene expression by organochlorine pesticides. Biochem. Pharmacol. 64, 1513-1519.
-
(2002)
Biochem. Pharmacol.
, vol.64
, pp. 1513-1519
-
-
Coumoul, X.1
Diry, M.2
Barouki, R.3
-
37
-
-
0032437889
-
Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element
-
Schuetz, E.G., Brimer,C., and Schuetz, J.D. (1998) Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element. Mol. Pharmacol. 54, 1113-1117.
-
(1998)
Mol. Pharmacol.
, vol.54
, pp. 1113-1117
-
-
Schuetz, E.G.1
Brimer, C.2
Schuetz, J.D.3
-
38
-
-
27744581965
-
Arsenite decreases CYP3A23 induction in cultured rat hepatocytes by transcriptional and translational mechanisms
-
Noreault, T. L., Jacobs, J. M., Nichols, R. C., Trask, H. W., Wrighton, S. A., Sinclair, P. R., Evans, R. M., and Sinclair, J. F. (2005) Arsenite decreases CYP3A23 induction in cultured rat hepatocytes by transcriptional and translational mechanisms. Toxicol. Appl. Pharmacol. 209, 174-182.
-
(2005)
Toxicol. Appl. Pharmacol.
, vol.209
, pp. 174-182
-
-
Noreault, T.L.1
Jacobs, J.M.2
Nichols, R.C.3
Trask, H.W.4
Wrighton, S.A.5
Sinclair, P.R.6
Evans, R.M.7
Sinclair, J.F.8
-
39
-
-
22344443829
-
Arsenite decreases CYP3A4 and RXRalpha in primary human hepatocytes
-
Noreault, T. L., Kostrubsky, V. E., Wood, S. G., Nichols, R. C., Strom, S. C., Trask, H. W., Wrighton, S. A., Evans, R. M., Jacobs, J. M., Sinclair, P. R., et al. (2005) Arsenite decreases CYP3A4 and RXRalpha in primary human hepatocytes. Drug Metab. Dispos. 33, 993-1003.
-
(2005)
Drug Metab. Dispos.
, vol.33
, pp. 993-1003
-
-
Noreault, T.L.1
Kostrubsky, V.E.2
Wood, S.G.3
Nichols, R.C.4
Strom, S.C.5
Trask, H.W.6
Wrighton, S.A.7
Evans, R.M.8
Jacobs, J.M.9
Sinclair, P.R.10
-
40
-
-
13844306334
-
Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites
-
Sonoda, J., Chong, L. W., Downes, M., Barish, G. D., Coulter, S., Liddle, C., Lee, C. H., and Evans, R. M. (2005) Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites. Proc. Natl Acad. Sci. USA 102, 2198-2203.
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 2198-2203
-
-
Sonoda, J.1
Chong, L.W.2
Downes, M.3
Barish, G.D.4
Coulter, S.5
Liddle, C.6
Lee, C.H.7
Evans, R.M.8
-
41
-
-
0033664347
-
Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: consequences on cytochrome P450 gene regulation
-
Pascussi, J. M., Gerbal-Chaloin, S., Fabre, J. M., Maurel, P., and Vilarem, M. J. (2000) Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: consequences on cytochrome P450 gene regulation. Mol. Pharmacol. 58, 1441-1450.
-
(2000)
Mol. Pharmacol.
, vol.58
, pp. 1441-1450
-
-
Pascussi, J.M.1
Gerbal-Chaloin, S.2
Fabre, J.M.3
Maurel, P.4
Vilarem, M.J.5
-
42
-
-
0033931266
-
Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators
-
Pascussi, J. M., Drocourt, L., Fabre, J. M., Maurel, P., and Vilarem, M. J. (2000) Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators. Mol. Pharmacol. 58, 361-372.
-
(2000)
Mol. Pharmacol.
, vol.58
, pp. 361-372
-
-
Pascussi, J.M.1
Drocourt, L.2
Fabre, J.M.3
Maurel, P.4
Vilarem, M.J.5
-
43
-
-
0033178677
-
Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation
-
Zhang, H., LeCulyse, E., Liu, L., Hu, M., Matoney, L., Zhu, W., and Yan, B. (1999) Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation. Arch. Biochem. Biophys. 368, 14-22.
-
(1999)
Arch. Biochem. Biophys.
, vol.368
, pp. 14-22
-
-
Zhang, H.1
LeCulyse, E.2
Liu, L.3
Hu, M.4
Matoney, L.5
Zhu, W.6
Yan, B.7
-
44
-
-
0038482452
-
Role of the hepatocyte nuclear factor 4alpha in control of the pregnane X receptor during fetal liver development
-
Kamiya, A., Inoue, Y., and Gonzalez, F. J. (2003) Role of the hepatocyte nuclear factor 4alpha in control of the pregnane X receptor during fetal liver development. Hepatology 37, 1375-1384.
-
(2003)
Hepatology
, vol.37
, pp. 1375-1384
-
-
Kamiya, A.1
Inoue, Y.2
Gonzalez, F.J.3
-
45
-
-
0026348597
-
The antiglucocorticoid RU486 down regulates the expression of interleukin-2 receptors in normal human lymphocytes
-
Antonakis, N., Markogiannakis, E., Theodoropoulou, M., Georgoulias, V., Stournaras, C., and Gravanis, A. (1991) The antiglucocorticoid RU486 down regulates the expression of interleukin-2 receptors in normal human lymphocytes. J. Steroid Biochem. Mol. Biol. 39, 929-935.
-
(1991)
J. Steroid Biochem. Mol. Biol.
, vol.39
, pp. 929-935
-
-
Antonakis, N.1
Markogiannakis, E.2
Theodoropoulou, M.3
Georgoulias, V.4
Stournaras, C.5
Gravanis, A.6
-
46
-
-
12144288241
-
Transcriptional suppression of cytochrome P450 genes by endogenous and exogenous chemicals
-
Riddick, D. S., Lee, C., Bhathena, A., Timsit, Y. E., Cheng, P. Y., Morgan, E. T., Prough, R. A., Ripp, S. L., Miller, K. K., Jahan, A., et al. (2004) Transcriptional suppression of cytochrome P450 genes by endogenous and exogenous chemicals. Drug Metab. Dispos. 32, 367-375.
-
(2004)
Drug Metab. Dispos.
, vol.32
, pp. 367-375
-
-
Riddick, D.S.1
Lee, C.2
Bhathena, A.3
Timsit, Y.E.4
Cheng, P.Y.5
Morgan, E.T.6
Prough, R.A.7
Ripp, S.L.8
Miller, K.K.9
Jahan, A.10
-
47
-
-
0031409592
-
Regulation of cytochromes P450 during inflammation and infection
-
Morgan, E. T. (1997) Regulation of cytochromes P450 during inflammation and infection. Drug Metab. Rev. 29, 1129-1188.
-
(1997)
Drug Metab. Rev.
, vol.29
, pp. 1129-1188
-
-
Morgan, E.T.1
-
48
-
-
0034637122
-
Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes
-
Pascussi, J. M., Gerbal-Chaloin, S., Pichard-Garcia, L., Daujat, M., Fabre, J. M., Maurel, P., and Vilarem, M. J. (2000) Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes. Biochem. Biophys. Res. Commun. 274, 707-713.
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.274
, pp. 707-713
-
-
Pascussi, J.M.1
Gerbal-Chaloin, S.2
Pichard-Garcia, L.3
Daujat, M.4
Fabre, J.M.5
Maurel, P.6
Vilarem, M.J.7
-
49
-
-
0036296149
-
Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response
-
Beigneux, A. P., Moser, A. H., Shigenaga, J. K., Grunfeld, C., and Feingold, K. R. (2002) Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response. Biochem. Biophys. Res. Commun. 293, 145-149.
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.293
, pp. 145-149
-
-
Beigneux, A.P.1
Moser, A.H.2
Shigenaga, J.K.3
Grunfeld, C.4
Feingold, K.R.5
-
50
-
-
33746675685
-
Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation
-
Zhou, C., Tabb, M. M., Nelson, E. L., Grun, F., Verma, S., Sadatrafiei, A., Lin, M.,Mallick, S., Forman, B. M., Thummel, K. E., et al. (2006) Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation. J. Clin. Invest. 116, 2280-2289.
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 2280-2289
-
-
Zhou, C.1
Tabb, M.M.2
Nelson, E.L.3
Grun, F.4
Verma, S.5
Sadatrafiei, A.6
Lin, M.7
Mallick, S.8
Forman, B.M.9
Thummel, K.E.10
-
51
-
-
0037108916
-
Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR)
-
Sonoda, J., Xie, W., Rosenfeld, J. M., Barwick, J. L., Guzelian, P. S., and Evans, R. M. (2002) Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR). Proc. Natl Acad. Sci. USA 99, 13801-13806.
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 13801-13806
-
-
Sonoda, J.1
Xie, W.2
Rosenfeld, J.M.3
Barwick, J.L.4
Guzelian, P.S.5
Evans, R.M.6
-
52
-
-
0036192731
-
Orphan nuclear receptor binding site in the human inducible nitric oxide synthase promoter mediates responsiveness to steroid and xenobiotic ligands
-
Toell, A., Kroncke, K. D., Kleinert, H., and Carlberg, C. (2002) Orphan nuclear receptor binding site in the human inducible nitric oxide synthase promoter mediates responsiveness to steroid and xenobiotic ligands. J. Cell Biochem. 85, 72-82.
-
(2002)
J. Cell Biochem.
, vol.85
, pp. 72-82
-
-
Toell, A.1
Kroncke, K.D.2
Kleinert, H.3
Carlberg, C.4
-
53
-
-
33744948052
-
A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway
-
Zhou, J., Zhai, Y., Mu, Y., Gong, H., Uppal, H., Toma, D., Ren, S., Evans, R. M., and Xie, W. (2006) A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway. J. Biol. Chem. 281, 15013-15020.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 15013-15020
-
-
Zhou, J.1
Zhai, Y.2
Mu, Y.3
Gong, H.4
Uppal, H.5
Toma, D.6
Ren, S.7
Evans, R.M.8
Xie, W.9
-
54
-
-
33845970888
-
Activation of pregnane X receptor disrupts glucocorticoid and mineralocorticoid homeostasis
-
Zhai, Y., Pai, H. V., Zhou, J., Amico, J. A., Vollmer, R. R., and Xie, W. (2007) Activation of pregnane X receptor disrupts glucocorticoid and mineralocorticoid homeostasis. Mol. Endocrinol. 21, 138-147.
-
(2007)
Mol. Endocrinol.
, vol.21
, pp. 138-147
-
-
Zhai, Y.1
Pai, H.V.2
Zhou, J.3
Amico, J.A.4
Vollmer, R.R.5
Xie, W.6
-
55
-
-
0031682988
-
The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene
-
Honkakoski, P., Zelko, I., Sueyoshi, T., andNegishi,M. (1998) The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene. Mol. Cell Biol. 18, 5652-5658.
-
(1998)
Mol. Cell Biol.
, vol.18
, pp. 5652-5658
-
-
Honkakoski, P.1
Zelko, I.2
Sueyoshi, T.3
Negishi, M.4
-
56
-
-
0035038008
-
Phenobarbital response elements of cytochrome P450 genes and nuclear receptors
-
Sueyoshi, T. and Negishi, M. (2001) Phenobarbital response elements of cytochrome P450 genes and nuclear receptors. Annu. Rev. Pharmacol. Toxicol. 41, 123-143.
-
(2001)
Annu. Rev. Pharmacol. Toxicol.
, vol.41
, pp. 123-143
-
-
Sueyoshi, T.1
Negishi, M.2
-
57
-
-
0032497544
-
Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta
-
Forman, B. M., Tzameli, I., Choi, H. S., Chen, J., Simha, D., Seol, W., Evans, R. M., and Moore, D. D. (1998) Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta. Nature 395, 612-615.
-
(1998)
Nature
, vol.395
, pp. 612-615
-
-
Forman, B.M.1
Tzameli, I.2
Choi, H.S.3
Chen, J.4
Simha, D.5
Seol, W.6
Evans, R.M.7
Moore, D.D.8
-
58
-
-
0033525886
-
The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene
-
Sueyoshi, T., Kawamoto, T., Zelko, I., Honkakoski, P., and Negishi, M. (1999) The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene. J. Biol. Chem. 274, 6043-6046.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 6043-6046
-
-
Sueyoshi, T.1
Kawamoto, T.2
Zelko, I.3
Honkakoski, P.4
Negishi, M.5
-
59
-
-
0034687397
-
The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism
-
Wei, P., Zhang, J., Egan-Hafley, M., Liang, S., and Moore, D. D. (2000) The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism. Nature 407, 920-923.
-
(2000)
Nature
, vol.407
, pp. 920-923
-
-
Wei, P.1
Zhang, J.2
Egan-Hafley, M.3
Liang, S.4
Moore, D.D.5
-
60
-
-
0037064177
-
Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR
-
Zhang, J., Huang, W., Chua, S. S., Wei, P., and Moore, D. D. (2002) Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR. Science 298, 422-424.
-
(2002)
Science
, vol.298
, pp. 422-424
-
-
Zhang, J.1
Huang, W.2
Chua, S.S.3
Wei, P.4
Moore, D.D.5
-
61
-
-
0034685779
-
Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands
-
Moore, L. B., Parks, D. J., Jones, S. A., Bledsoe, R. K., Consler, T. G., Stimmel, J. B., Goodwin, B., Liddle, C., Blanchard, S. G., Willson, T. M., et al. (2000) Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. J. Biol. Chem. 275, 15122-15127.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 15122-15127
-
-
Moore, L.B.1
Parks, D.J.2
Jones, S.A.3
Bledsoe, R.K.4
Consler, T.G.5
Stimmel, J.B.6
Goodwin, B.7
Liddle, C.8
Blanchard, S.G.9
Willson, T.M.10
-
62
-
-
5044237671
-
Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR
-
Huang, W., Zhang, J., Wei, P., Schrader, W. T., and Moore, D. D. (2004) Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR. Mol. Endocrinol. 18, 2402-2408.
-
(2004)
Mol. Endocrinol.
, vol.18
, pp. 2402-2408
-
-
Huang, W.1
Zhang, J.2
Wei, P.3
Schrader, W.T.4
Moore, D.D.5
-
63
-
-
23944487083
-
Di-n-butyl phthalate activates constitutive androstane receptor and pregnane X receptor and enhances the expression of steroidmetabolizing enzymes in the liver of rat fetuses
-
Wyde, M. E., Kirwan, S. E., Zhang, F., Laughter, A., Hoffman, H. B., Bartolucci-Page, E., Gaido, K. W., Yan, B., and You, L. (2005) Di-n-butyl phthalate activates constitutive 58 ESTABLISHING ORPHAN NUCLEAR RECEPTORS PXR AND CAR androstane receptor and pregnane X receptor and enhances the expression of steroidmetabolizing enzymes in the liver of rat fetuses. Toxicol. Sci. 86, 281-290.
-
(2005)
Toxicol. Sci.
, vol.86
, pp. 281-290
-
-
Wyde, M.E.1
Kirwan, S.E.2
Zhang, F.3
Laughter, A.4
Hoffman, H.B.5
Bartolucci-Page, E.6
Gaido, K.W.7
Yan, B.8
You, L.9
-
64
-
-
0037931737
-
Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes
-
Maglich, J. M., Parks, D. J., Moore, L. B., Collins, J. L., Goodwin, B., Billin, A. N., Stoltz, C. A., Kliewer, S. A., Lambert,M. H.,Willson, T. M., et al. (2003) Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes. J. Biol. Chem. 278, 17277-17283.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 17277-17283
-
-
Maglich, J.M.1
Parks, D.J.2
Moore, L.B.3
Collins, J.L.4
Goodwin, B.5
Billin, A.N.6
Stoltz, C.A.7
Kliewer, S.A.8
Lambert, M.H.9
Willson, T.M.10
-
65
-
-
33846230463
-
Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole
-
Huang, H., Wang, H., Sinz, M., Zoeckler, M., Staudinger, J., Redinbo, M. R., Teotico, D. G., Locker, J., Kalpana, G. V., and Mani, S. (2007) Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole. Oncogene 26, 258-268.
-
(2007)
Oncogene
, vol.26
, pp. 258-268
-
-
Huang, H.1
Wang, H.2
Sinz, M.3
Zoeckler, M.4
Staudinger, J.5
Redinbo, M.R.6
Teotico, D.G.7
Locker, J.8
Kalpana, G.V.9
Mani, S.10
-
66
-
-
0033999734
-
The xenobiotic compound 1,4-bis[2-(3 5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR
-
Tzameli, I., Pissios, P., Schuetz, E. G., andMoore, D. D. (2000) The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR. Mol. Cell Biol. 20, 2951-2958.
-
(2000)
Mol. Cell Biol.
, vol.20
, pp. 2951-2958
-
-
Tzameli, I.1
Pissios, P.2
Schuetz, E.G.3
Moore, D.D.4
-
67
-
-
0037135532
-
Glucocorticoid receptor-interacting protein 1 mediates ligand-independent nuclear translocation and activation of constitutive androstane receptor in vivo
-
Min, G., Kemper, J. K., and Kemper, B. (2002) Glucocorticoid receptor-interacting protein 1 mediates ligand-independent nuclear translocation and activation of constitutive androstane receptor in vivo. J. Biol. Chem. 277, 26356-26363.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 26356-26363
-
-
Min, G.1
Kemper, J.K.2
Kemper, B.3
-
68
-
-
22444448890
-
Characterization of activating signal cointegrator-2 as a novel transcriptional coactivator of the xenobiotic nuclear receptor constitutive androstane receptor
-
Choi, E., Lee, S., Yeom, S. Y., Kim, G. H., Lee, J. W., and Kim, S. W. (2005) Characterization of activating signal cointegrator-2 as a novel transcriptional coactivator of the xenobiotic nuclear receptor constitutive androstane receptor. Mol. Endocrinol. 19, 1711-1719.
-
(2005)
Mol. Endocrinol.
, vol.19
, pp. 1711-1719
-
-
Choi, E.1
Lee, S.2
Yeom, S.Y.3
Kim, G.H.4
Lee, J.W.5
Kim, S.W.6
-
69
-
-
0038514189
-
Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferatoractivated receptor gamma coactivator-1 alpha Apossible link between xenobiotic response and nutritional state
-
Shiraki, T., Sakai, N., Kanaya, E., and Jingami, H. (2003) Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferatoractivated receptor gamma coactivator-1 alpha.Apossible link between xenobiotic response and nutritional state. J. Biol. Chem. 278, 11344-11350.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 11344-11350
-
-
Shiraki, T.1
Sakai, N.2
Kanaya, E.3
Jingami, H.4
-
70
-
-
0035076197
-
The peptide near the C terminus regulates receptor CAR nuclear translocation induced by xenochemicals in mouse liver
-
Zelko, I., Sueyoshi, T., Kawamoto, T.,Moore, R., and Negishi, M. (2001) The peptide near the C terminus regulates receptor CAR nuclear translocation induced by xenochemicals in mouse liver. Mol. Cell Biol. 21, 2838-2846.
-
(2001)
Mol. Cell Biol.
, vol.21
, pp. 2838-2846
-
-
Zelko, I.1
Sueyoshi, T.2
Kawamoto, T.3
Moore, R.4
Negishi, M.5
-
71
-
-
33847024555
-
CAR and PXR: the xenobiotic-sensing receptors
-
Timsit, Y. E. and Negishi, M. (2007) CAR and PXR: the xenobiotic-sensing receptors. Steroids 72, 231-246.
-
(2007)
Steroids
, vol.72
, pp. 231-246
-
-
Timsit, Y.E.1
Negishi, M.2
-
72
-
-
0032766430
-
Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene
-
Kawamoto, T., Sueyoshi, T., Zelko, I., Moore, R., Washburn, K., and Negishi, M. (1999) Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene. Mol. Cell Biol. 19, 6318-6322.
-
(1999)
Mol. Cell Biol.
, vol.19
, pp. 6318-6322
-
-
Kawamoto, T.1
Sueyoshi, T.2
Zelko, I.3
Moore, R.4
Washburn, K.5
Negishi, M.6
-
73
-
-
0142210183
-
Cytoplasmic accumulation of the nuclear receptor CAR by a tetratricopeptide repeat protein in HepG2 cells
-
Kobayashi, K., Sueyoshi, T., Inoue, K., Moore, R., and Negishi, M. (2003) Cytoplasmic accumulation of the nuclear receptor CAR by a tetratricopeptide repeat protein in HepG2 cells. Mol. Pharmacol. 64, 1069-1075.
-
(2003)
Mol. Pharmacol.
, vol.64
, pp. 1069-1075
-
-
Kobayashi, K.1
Sueyoshi, T.2
Inoue, K.3
Moore, R.4
Negishi, M.5
-
74
-
-
28844498056
-
Localization of the nuclear receptor CAR at the cell membrane of mouse liver
-
Koike, C., Moore, R., and Negishi, M. (2005) Localization of the nuclear receptor CAR at the cell membrane of mouse liver. FEBS Lett. 579, 6733-6736.
-
(2005)
FEBS Lett
, vol.579
, pp. 6733-6736
-
-
Koike, C.1
Moore, R.2
Negishi, M.3
-
75
-
-
8344219885
-
Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver
-
Squires, E. J., Sueyoshi, T., and Negishi, M. (2004) Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver. J. Biol. Chem. 279, 49307-49314.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 49307-49314
-
-
Squires, E.J.1
Sueyoshi, T.2
Negishi, M.3
-
76
-
-
33747169939
-
Cohesin protein SMC1 represses the nuclear receptor CAR-mediated synergistic activation of a human P450 gene by xenobiotics
-
Inoue,K., Borchers, C.H., andNegishi,M. (2006) Cohesin protein SMC1 represses the nuclear receptor CAR-mediated synergistic activation of a human P450 gene by xenobiotics. Biochem. J. 398, 125-133.
-
(2006)
Biochem. J.
, vol.398
, pp. 125-133
-
-
Inoue, K.1
Borchers, C.H.2
Negishi, M.3
-
77
-
-
33846502281
-
In the regulation of cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of AMPactivated protein kinase
-
Blattler, S. M., Rencurel, F., Kaufmann, M. R., and Meyer, U. A. (2007) In the regulation of cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of AMPactivated protein kinase. Proc. Natl Acad. Sci. USA 104, 1045-1050.
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 1045-1050
-
-
Blattler, S.M.1
Rencurel, F.2
Kaufmann, M.R.3
Meyer, U.A.4
-
78
-
-
15644384598
-
AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line
-
Rencurel, F., Stenhouse, A., Hawley, S. A., Friedberg, T., Hardie, D. G., Sutherland, C., and Wolf, C. R. (2005) AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line. J. Biol. Chem. 280, 4367-4373.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 4367-4373
-
-
Rencurel, F.1
Stenhouse, A.2
Hawley, S.A.3
Friedberg, T.4
Hardie, D.G.5
Sutherland, C.6
Wolf, C.R.7
-
79
-
-
33846886331
-
A physiological role of AMP-activated protein kinase in phenobarbital-mediated constitutive androstane receptor activation and CYP2B induction
-
Shindo, S., Numazawa, S., and Yoshida, T. (2007) A physiological role of AMP-activated protein kinase in phenobarbital-mediated constitutive androstane receptor activation and CYP2B induction. Biochem. J. 401, 735-741.
-
(2007)
Biochem. J.
, vol.401
, pp. 735-741
-
-
Shindo, S.1
Numazawa, S.2
Yoshida, T.3
-
80
-
-
4644240254
-
Interleukin 1beta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance
-
Assenat, E., Gerbal-Chaloin, S., Larrey, D., Saric, J., Fabre, J. M., Maurel, P., Vilarem, M. J., and Pascussi, J. M. (2004) Interleukin 1beta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance. Hepatology 40, 951-960.
-
(2004)
Hepatology
, vol.40
, pp. 951-960
-
-
Assenat, E.1
Gerbal-Chaloin, S.2
Larrey, D.3
Saric, J.4
Fabre, J.M.5
Maurel, P.6
Vilarem, M.J.7
Pascussi, J.M.8
-
81
-
-
0037169551
-
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor
-
Kast, H. R., Goodwin, B., Tarr, P. T., Jones, S. A., Anisfeld, A. M., Stoltz, C.M., Tontonoz, P., Kliewer, S., Willson, T. M., and Edwards, P. A. (2002) Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J. Biol. Chem. 277, 2908-2915.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 2908-2915
-
-
Kast, H.R.1
Goodwin, B.2
Tarr, P.T.3
Jones, S.A.4
Anisfeld, A.M.5
Stoltz, C.M.6
Tontonoz, P.7
Kliewer, S.8
Willson, T.M.9
Edwards, P.A.10
-
82
-
-
0037386735
-
Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor
-
Xie, W., Yeuh, M. F., Radominska-Pandya, A., Saini, S. P., Negishi, Y., Bottroff, B. S., Cabrera, G. Y., Tukey, R. H., and Evans, R. M. (2003) Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor. Proc. Natl Acad. Sci. USA 100, 4150-4155.
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 4150-4155
-
-
Xie, W.1
Yeuh, M.F.2
Radominska-Pandya, A.3
Saini, S.P.4
Negishi, Y.5
Bottroff, B.S.6
Cabrera, G.Y.7
Tukey, R.H.8
Evans, R.M.9
-
83
-
-
0035201366
-
Rifampin is a selective, pleiotropic inducer of drug metabolism genes in human hepatocytes: studies with cDNA and oligonucleotide expression arrays
-
Rae, J. M., Johnson, M. D., Lippman, M. E., and Flockhart, D. A. (2001) Rifampin is a selective, pleiotropic inducer of drug metabolism genes in human hepatocytes: studies with cDNA and oligonucleotide expression arrays. J. Pharmacol. Exp. Ther. 299, 849-857.
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.299
, pp. 849-857
-
-
Rae, J.M.1
Johnson, M.D.2
Lippman, M.E.3
Flockhart, D.A.4
-
84
-
-
0036765785
-
Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification
-
Maglich, J. M., Stoltz, C.M., Goodwin, B., Hawkins-Brown, D.,Moore, J. T., and Kliewer, S. A. (2002) Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification. Mol. Pharmacol. 62, 638-646.
-
(2002)
Mol. Pharmacol.
, vol.62
, pp. 638-646
-
-
Maglich, J.M.1
Stoltz, C.M.2
Goodwin, B.3
Hawkins-Brown, D.4
Moore, J.T.5
Kliewer, S.A.6
-
85
-
-
0036142429
-
Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital
-
Ueda, A., Hamadeh, H. K., Webb, H. K., Yamamoto, Y., Sueyoshi, T., Afshari, C. A., Lehmann, J. M., and Negishi, M. (2002) Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital. Mol. Pharmacol. 61, 1-6.
-
(2002)
Mol. Pharmacol.
, vol.61
, pp. 1-6
-
-
Ueda, A.1
Hamadeh, H.K.2
Webb, H.K.3
Yamamoto, Y.4
Sueyoshi, T.5
Afshari, C.A.6
Lehmann, J.M.7
Negishi, M.8
-
86
-
-
0033630046
-
Identification of phenobarbitone-modulated genes in mouse liver by differential display
-
Garcia-Allan, C., Lord, P. G., Loughlin, J. M., Orton, T. C., and Sidaway, J. E. (2000) Identification of phenobarbitone-modulated genes in mouse liver by differential display. J. Biochem. Mol. Toxicol. 14, 65-72.
-
(2000)
J. Biochem. Mol. Toxicol.
, vol.14
, pp. 65-72
-
-
Garcia-Allan, C.1
Lord, P.G.2
Loughlin, J.M.3
Orton, T.C.4
Sidaway, J.E.5
-
87
-
-
0035029401
-
The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR
-
Sugatani, J., Kojima, H., Ueda, A., Kakizaki, S., Yoshinari, K., Gong, Q. H., Owens, I. S., Negishi, M., and Sueyoshi, T. (2001) The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR. Hepatology 33, 1232-1238.
-
(2001)
Hepatology
, vol.33
, pp. 1232-1238
-
-
Sugatani, J.1
Kojima, H.2
Ueda, A.3
Kakizaki, S.4
Yoshinari, K.5
Gong, Q.H.6
Owens, I.S.7
Negishi, M.8
Sueyoshi, T.9
|