Arsenite decreases CYP3A4 and RXRα in primary human hepatocytes

Drug Metabolism and Disposition

Volumn 33, Issue 7, 2005, Pages 993-1003

  Noreault, Trisha L ^a,b   Kostrubsky, Vsevolod E ^c   Wood, Sheryl G ^b   Nichols, Ralph C ^a,b   Strom, Stephen C ^d   Trask, Heidi W ^a,b   Wrighton, Steven A ^e   Evans, Ronald M ^f   Jacobs, Judith M ^a,b   Sinclair, Peter R ^a,b   Sinclair, Jacqueline F ^a,b  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b VA MEDICAL CENTER   (United States)

^c PFIZER INC   (United States)

^d UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^e ELI LILLY AND COMPANY   (United States)

^f HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARSENIC TRIOXIDE; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 3A4; MESSENGER RNA; PHENOBARBITAL; PREGNANE X RECEPTOR; RETINOID X RECEPTOR; RIFAMPICIN; TOXIC SUBSTANCE; TRANSCRIPTION FACTOR SP1;

AEROBIC METABOLISM; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME INDUCTION; GENE CONTROL; GENETIC TRANSCRIPTION; HUMAN; HUMAN TISSUE; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALIA;

EID: 22344443829     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.105.003954     Document Type: Article

References (55)

1. Albores A, Cebrian M, Connelly J, Bach P, and Bridges J (1992) Effect of arsenite on hepatic mixed-function oxidase activity in rats. Xenobiotica 22:591-597.
2. Assenat A, Gerbal-Chaloin S, Larrey D, Saric J, Fabre J, Maurel P, Vilarem M, and Pascussi J (2004) Interleukin 1β inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance. Hepatology 40:951-960.
3. Bertilsson G, Heidrich J, Svensson K, Asman M, Jendeberg L, Sydow-Backman M, Ohlsson R, Postlind H, Blomquist P, and Berkenstam M (1998) Identification of a human nuclear receptor defines a new signaling pathway for CYP3A4 induction. Proc Natl Acad Sci USA 95:12208-12213.
4. Bessette E, Fasco M, Pentecost B, and Kaminsky L (2005) Mechanisms of arsenite-mediated decreases in benzo(k)fluoranthene-induced human cytochrome P4501A1 levels in HepG2 cells. Drug Metab Dispos 33:312-320.
5. Blumberg B, Sabbagh W, Juguilon H, Bolado J, van Meter C, Ong E, and Evans R (1998) SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes Dev 12:3195-3205.
6. Bodwell J, Kingsley L, and Hamilton J (2004) Arsenic at very low concentrations alters glucocorticoid receptor (GR)-mediated gene activation but not GR-mediated gene repression: complex dose-response effects are closely correlated with levels of activated GR and require a functional GR DNA binding domain. Chem Res Toxicol 17:1064-1076.
7. Bombail V, Taylor K, Gibson G, and Plant N (2004) Role of Sp1, C/EBPα, HNF3 and PXR in the basal- and xenobiotic-mediated regulation of the CYP3A4 gene. Drug Metab Dispos 32:525-535.
8. Burger H, Schuetz J, Schuetz E, and Guzelian P (1992) Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes. Proc Natl Acad Sci USA 89:2145-2149.
9. Chen A, Cao E, Zhang T, and Qin J (2002) Arsenite-induced reactive oxygen species and the repression of α-tocopherol in the MGC-803 cells. Eur J Pharmacol 448:11-18.
10. Chou W, Hawkins A, Barett J, Griffith C, and Dang C (2001) Arsenic inhibition of telomerase transcription leads to genetic instability. J Clin Investig 108:1541-1547.
11. Daujat M, Pichard L, Fabre I, Pineau T, Fabre G, Bonfils C, and Maurel P (1991) Induction protocols for cytochromes P450IIIA in vivo and in primary cultures of animal and human hepatocytes. Methods Enzymol 206:345-353.
12. de Arruda M, Lyamichev V, Eis P, Iszczyszyn W, Kwiatkowski R, Law S, Olson M, and Rasmussen E (2002) Invader technology for DNA and RNA analysis: principles and applications. Expert Rev Mol Diagn 2:487-496.
13. Del Razo L, Quintanilla-Vega B, Brambila-Colombres E, Calderon-Aranda E, Manno M, and Albores A (2001) Stress proteins induced by arsenic. Toxicol Appl Pharmacol 177:132-148.
14. Evans W and Relling M (1999) Pharmacogenomics: translating functional genomics into rational therapeutics. Science (Wash DC) 286:487-491.
15. Evens A, Tallman M, and Gartenhaus R (2004) The potential of arsenic trioxide in the treatment of malignant disease: past, present and future. Leuk Res 28:891-900.
16. Ferrini J, Pichard L, Domergue J, and Maurel P (1997) Long-term primary cultures of adult human hepatocytes. Chem-Biol Interact 107:31-45.
17. Ghose R, Zimmerman T, Thevananther S, and Karpen S (2004) Endotoxin leads to rapid subcellular re-localization of hepatic RXRα: a novel mechanism for reduced hepatic gene expression in inflammation. Nucl Recept 2:4.
18. Goodwin B, Hodgson E, D'Costa D, Robertson G, and Liddle C (2002a) Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor. Mol Pharmacol 62:359-365.
19. Goodwin B, Redinbo M, and Kliewer S (2002b) Regulation of Cyp3a gene transcription by the pregnane X receptor. Annu Rev Pharmacol Toxicol 42:1-23.
20. Hamilton J, Bement W, Sinclair J, Sinclair P, and Wetterhahn K (1988) Expression of 5-aminolevulinate synthase and cytochrome P450 mRNA in chick embryo hepatocytes in vivo and in culture. Biochem J 255:267-275.
21. Huang C, Li J, Ding M, Costa M, Castranova V, Vallyathan V, Ju G, and Shi X (2001) Transactivation of RARE and GRE in the cellular response to arsenic. Mol Cell Biochem 222:119-125.
22. Hutchinson J (1888) On some examples of arsenic-keratoses of the skin and arsenic cancer. Trans Pathol Soc (Lond) 39:352-363.
23. Jacobs J, Nichols C, Andrew A, Marek D, Wood S, Sinclair P, and Sinclair J (1999) Effect of arsenite on induction of CYP1A, CYP2B and CYP3A in primary cultures of rat hepatocytes. Toxicol Appl Pharmacol 157:51-59.
24. Jover R, Bort R, Gomez-Lechon M, and Castell J (2001) Cytochrome P450 regulation by hepatocyte nuclear factor 4 in human hepatocytes: a study using adenovirus-mediated antisense targeting. Hepatology 33:668-675.
25. Kaltreider R, Davis A, Lariviere J, and Hamilton J (2001) Arsenic alters the function of the glucocorticoid receptor as a transcription factor. Environ Health Perspect 109:245-251.
26. Kocarek T, Schuetz E, Strom S, Fisher R, and Guzelian P (1995) Comparative analysis of cytochrome P4503A induction in primary cultures of rat, rabbit and human hepatocytes. Drug Metab Dispos 23:415-421.
27. Kostrubsky V, Lewis L, Wood S, Sinclair P, Wrighton S, and Sinclair J (1997) Effect of taxol on cytochrome P450 3A and acetaminophen toxicity in cultured rat hepatocytes: comparison to dexamethasone. Toxicol Appl Pharmacol 142:79-86.
28. Kostrubsky V, Ramachandran V, Venkataramanan R, Dorko K, Esplen J, Zhang S, Sinclair J, Wrighton S, and Strom S (1999) The use of human hepatocyte cultures to study the induction of cytochrome P-450. Drug Metab Dispos 27:887-894.
29. Lehmann J, McKee D, Watson M, Willson M, Moore J, and Kliewer S (1998) The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J Clin Investig 102:1016-1023.
30. Li A, Kaminski D, and Rasmussen A (1995) Substrates of human hepatic cytochrome P450 3A4. Toxicology 104:1-8.
31. Lowry OH, Rosebrough NJ, Farr AL, and Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275.
32. Madan A, Graham R, Carroll K, Mudra D, Burton L, Krueger L, Downey A, Czerwinski M, Forster J, Ribadeneira M, et al. (2003) Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes. Drug Metab Dispos 31:421-431.
33. Moore L, Parks D, Jones S, Bledsoe R, Consler T, Stimmel J, Goodwin B, Liddle C, Blanchard S, Willson T, et al. (2000) Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. J Biol Chem 275:15122-15127.
34. Morel I, Lescoat G, Cillard J, Pasdeloup N, Brissot P, and Cillard P (1990) Kinetic evaluation of free malondialdehyde and enzyme leakage as indices of iron damage in rat hepatocyte cultures. Biochem Pharmacol 39:1647-1655.
35. Nelson D, Koymans L, Kamataki T, Stegeman J, Feyereisen R, Waxman D, Waterman M, Gotoh O, Coon M, Estabrook R, et al. (1996) P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics 6:1-42.
36. Pascussi J, Drocourt L, Fabre J, Maurel P, and Vilarem M (2000a) Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction of by pregnane X receptor activators. Mol Pharmacol 58:361-372.
37. Pascussi J, Gerbal-Chaloin S, Fabre J, Maurel P, and Vilarem M (2000b) Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: consequences on cytochrome P450 gene regulation. Mol Pharmacol 58:1441-1450.
38. Rousselot P, Larghero J, Arnulf B, Poupon J, Royer B, Tibi A, Madelaine-Chambrin I, Cimerman P, Chevret S, Hermine O, et al. (2004) A clinical and pharmacological study of arsenic trioxide in advanced multiple myeloma patients. Leukemia (Baltimore) 18:1518-1521.
39. Runge D, Kohler C, Kostrubsky V, Jager D, Lehmann T, Runge D, May U, Beer Stolz D, Strom S, Fleig W, et al. (2000) Induction of cytochrome P450 (CYP)1A1, CYP1A2 and CYP3A4 but not of CYP2C9, CYP2C19, multidrug resistance (MDR-1) and multidrug resistance associated protein (MRP-1) by prototypical inducers in human hepatocytes. Biochem Biophys Res Commun 273:333-341.
40. Sardana M, Drummond G, Sassa S, and Kappas A (1981) The potent heme oxygenase inducing action of arsenic and parasiticidal arsenicals. Pharmacology 23:247-253.
41. Shedlofsky S, Bonkowsky H, Sinclair P, Sinclair J, Bement W, and Pomeroy J (1983) Iron loading of cultured hepatocytes. Effect of iron on 5-aminolaevulinate synthase is independent of lipid peroxidation. Biochem J 212:321-330.
42. Shimada T, Gillam E, Sandhu P, Guo Z, Tukey R, and Guengerich F (1994) Activation of procarcinogens by human cytochrome P450 enzymes expressed in Escherichia coli. Simplified bacterial systems for genotoxicity assays. Carcinogenesis 15:2523-2529.
43. Sinclair P, Bement W, Haugen S, Sinclair J, and Guzelian P (1990) Induction of cytochrome P-450 and 5-aminolevulinate synthase activities in cultured rat hepatocytes. Cancer Res 50:5219-5224.
44. Spink D, Katz B, Hussain M, Spink B, Wu S, Liu N, Pause P, and Kaminsky L (2002) Induction of CYP1A1 and CYP1B1 in T-47D human breast cancer cells by benzo[a]pyrene is diminished by arsenite. Drug Metab Dispos 30:262-269.
45. Squires E, Sueyoshi T, and Negishi M (2004) Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear localization in mouse liver. J Biol Chem 279:49307-49314.
46. Strom S, Pisarov L, Dorko K, Thompson M, Schuetz J, and Schuetz E (1996) Use of human hepatocytes to study P450 gene induction. Methods Enzymol 272:388-401.
47. Sueyoshi T and Negishi M (2001) Phenobarbital response elements of cytochrome P450 genes and nuclear receptors. Annu Rev Pharmacol Toxicol 41:123-143.
48. Vakharia D, Liu N, Pause R, Fasco M, Bessette E, Zhang Q, and Kaminsky L (2001) Effect of metals on polycyclic aromatic hydrocarbon induction of CYP1A1 and CYP1A2 in human hepatocyte cultures. Toxicol Appl Pharmacol 170:93-103.
49. Vernhet L, Allain N, Vee M, Morel F, Guillouzo A, and Fardel O (2003) Blockage of multidrug resistance-associated proteins potentiates the inhibitory effects of arsenic trioxide on CYP1A1 induction by polycyclic aromatic hydrocarbons. J Pharmacol Exp Ther 304:145-155.
50. Whitlock J (1999) Induction of cytochrome P4501A1. Annu Rev Pharmacol Toxicol 39:103-125.
51. Wrighton S, Brian W, Sari M, Iwasaki M, Guengerich F, Raucy J, Molowa D, and Vandenbranden M (1990) Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3). Mol Pharmacol 38:207-213.
52. Xie W, Barwick J, Downes M, Blumberg B, Simon C, Nelson M, Neuschwander-Tetri B, Brunt E, Guzelian P, and Evans R (2000a) Humanized xenobiotic response in mice expressing nuclear receptor SXR. Nature (Lond) 406:435-439.
53. Xie W, Barwick J, Pierce C, Safe S, Blumberg B, Guzelian P, and Evans R (2000b) Reciprocal activation of xenobiotics response genes by nuclear receptors SXR/PXR and CAR. Genes Dev 14:3014-3023.
54. Ye X, Liu S, Wu Q, Lin X, Zhang B, Wu J, Zhang M, and Su W (2003) Degradation of retinoid X receptor α by TPA through proteasome pathway in gastric cancer cells. World J Gastroenterol 9:1915-1919.
55. Yoshida T, Yamauchi H, and Sun G (2004) Chronic health effects in people exposed to arsenic via the drinking water: dose-response relationships in review. Toxicol Appl Pharmacol 198:243-252.