Molecular inflammation as an underlying mechanism of the aging process and age-related diseases

Journal of Dental Research

Volumn 90, Issue 7, 2011, Pages 830-840

  Chung, H Y ^a   Lee, E K ^a   Choi, Y J ^a   Kim, J M ^a   Kim, D H ^b   Zou, Y ^c   Kim, C H ^d   Lee, J ^a   Kim, H S ^a   Kim, N D ^a   Jung, J H ^a   Yu, B P ^e  

^a Pusan National University   (South Korea)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d TheragenEtex Inc   (South Korea)

^e UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Age related diseases; Aging; Cytokines; Gingivitis; Inflammation; Oxidative stress

Indexed keywords

AUTACOID; CELL ADHESION MOLECULE; FORKHEAD TRANSCRIPTION FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOXYGENASE; PROSTAGLANDIN SYNTHASE;

AGING; ANIMAL; ATHEROSCLEROSIS; CALORIC RESTRICTION; CHRONIC PERIODONTITIS; HUMAN; INFLAMMATION; METABOLIC SYNDROME X; METABOLISM; OSTEOPOROSIS; OXIDATIVE STRESS; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

AGING; ANIMALS; ATHEROSCLEROSIS; CALORIC RESTRICTION; CELL ADHESION MOLECULES; CHRONIC PERIODONTITIS; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; LIPOXYGENASE; METABOLIC SYNDROME X; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; OSTEOPOROSIS; OXIDATIVE STRESS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SIGNAL TRANSDUCTION;

EID: 84884211315     PISSN: 00220345     EISSN: 15440591     Source Type: Journal    
DOI: 10.1177/0022034510387794     Document Type: Review

References (144)

1. Accili D, Arden KC (2004). FOXOS at the crossroads of cellular metabolism, differentiation, and transformation. Cell 117:421-426. (Pubitemid 38610228)
2. Bäck M, Hlawaty H, Labat C, Michel JB, Brink C (2007). The oral cavity and age: a site of chronic inflammation? PLoS One 2:e135.
3. Baek BS, Kwon HJ, Lee KH, Yoo MA, Kim KW, Ikeno Y, et al. (1999). Regional difference of ROS generation, lipid peroxidation and antioxidant enzyme activity in rat brain and their dietary modulation. Arch Pharm Res 22:361-366.
4. Baldwin AS Jr (1996). The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 14:649-683. (Pubitemid 26130197)
5. Bartke A (2008). Insulin and aging. Cell Cycle 7:3338-3334.
6. Boskey A, Coleman R (2010). Aging and bone. J Dent Res 89:1333-1348.
7. Bouallegue A, Vardatsikos G, Srivastava AK (2009). Role of insulin-like growth factor 1 receptor and c-Src in endothelin-1-and angiotensin II-induced PKB phosphorylation, and hypertrophic and proliferative responses in vascular smooth muscle cells. Can J Physiol Pharmacol 87:1009-1018.
8. Breese CR, Ingram RL, Sonntag WE (1991). Influence of age and long-term dietary restriction on plasma insulin-like growth factor-1 (IGF-1), IGF-1 gene expression, and IGF-1 binding proteins. J Gerontol 46:B180-B187.
9. Bruunsgaard H, Andersen-Ranberg K, Jeune B, Pedersen AN, Skinhøj P, Pedersen BK (1999). A high plasma concentration of TNF-alpha is associated with dementia in centenarians. J Gerontol A Biol Sci Med Sci 54:M357-M364. (Pubitemid 129785358)
10. Bruunsgaard H, Andersen-Ranberg K, Hjelmborg JB, Pedersen BK, Jeune B (2003a). Elevated levels of tumor necrosis factor alpha and mortality in centenarians. Am J Med 115:278-283. (Pubitemid 37088189)
11. Bruunsgaard H, Ladelund S, Pedersen AN, Schroll M, Jørgensen T, Pedersen BK (2003b). Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people. Clin Exp Immunol 132:24-31. (Pubitemid 36418902)
12. Bullon P, Morillo JM, Ramirez-Tortosa MC, Quiles JL, Newman HN, Battino M (2009a) Metabolic syndrome and periodontitis: is oxidative stress a common link? J Dent Res 88:503-518.
13. Bullon P, Quiles JL, Morillo JM, Rubini C, Goteri G, Granados-Principal S, et al. (2009b). Gingival vascular damage in atherosclerotic rabbits: hydroxytyrosol and squalene benefits. Food Chem Toxicol 47:2327-2331.
14. Burgering BM, Medema RH (2003). Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty. J Leukoc Biol 73:689-701. (Pubitemid 38040447)
15. Byrne CD (2010). Fatty liver: role of inflammation and fatty acid nutrition. Prostaglandins Leukot Essent Fatty Acids 82:265-271.
16. Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, et al. (2005). Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med 11:183-190. (Pubitemid 40321354)
17. Cantó C, Auwerx J (2009). Caloric restriction, SIRT1 and longevity. Trends Endocrinol Metab 20:325-331.
18. Carter CS, Hofer T, Seo AY, Leeuwenburgh C (2007). Molecular mechanisms of life-and health-span extension: role of calorie restriction and exercise intervention. Appl Physiol Nutr Metab 32:954-966.
19. Cartier A, Côté M, Lemieux I, Pérusse L, Tremblay A, Bouchard C, et al. (2009). Age-related differences in inflammatory markers in men: contribution of visceral adiposity. Metabolism 58:1452-1458.
20. Cesari M, Penninx BW, Pahor M, Lauretani F, Corsi AM, Rhys Williams G, et al. (2004). Inflammatory markers and physical performance in older persons: the InCHIANTI study. J Gerontol A Biol Sci Med Sci 59:242-248. (Pubitemid 38375337)
21. Chapple IL (2009). Potential mechanisms underpinning the nutritional modulation of periodontal inflammation. J Am Dent Assoc 140:178-184.
22. Chapple IL, Matthews JB (2007). The role of reactive oxygen and antioxidant species in periodontal tissue destruction. Periodontol 2000 43:160-232.
23. Chapple IL, Milward MR, Dietrich T (2007). The prevalence of inflammatory periodontitis is negatively associated with serum antioxidant concentrations. J Nutr 137:657-664. (Pubitemid 46397499)
24. Chinetti G, Fruchart JC, Staels B (2000). Peroxisome proliferator- activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation. Inflamm Res 49:497-505.
25. Chiribau CB, Cheng L, Cucoranu IC, Yu YS, Clempus RE, Sorescu D (2008). FOX03A regulates peroxiredoxin III expression in human cardiac fibroblasts. J Biol Chem 283:8211-8217.
26. Cho CG, Kim HJ, Chung SW, Jung KJ, Shim KH, Yu BP, et al. (2003). Modulation of glutathione and thioredoxin systems by calorie restriction during the aging process. Exp Gerontol 38:539-548. (Pubitemid 36549040)
27. Choi JH, Yu BP (1998). Dietary restriction as a modulator of age-related changes in rat kidney prostaglandin production. J Nutr Health Aging 2:167-171. (Pubitemid 128694834)
28. Chung HY, Kim HJ, Shim KH, Kim KW (1999). Dietary modulation of prostanoid synthesis in the aging process: role of cyclooxygenase-2. Mech Ageing Dev 111:97-106.
29. Chung H Y, Kim HJ, Kim JW, Yu BP (2001). The inflammation hypothesis of aging: molecular modulation by calorie restriction. Ann NY Acad Sci 928:327-335.
30. Chung HY, Kim HJ, Kim KW, Choi JS, Yu BP (2002). Molecular inflammation hypothesis of aging based on the anti-aging mechanism of calorie restriction. Microsc Res Tech 59:264-272. (Pubitemid 35332944)
31. Chung HY, Sung B, Jung KJ, Zou Y, Yu BP (2006). The molecular inflammatory process in aging. Antioxid Redox Signal 8:572-581. (Pubitemid 43741326)
32. Chung HY, Cesari M, Anton S, Marzetti E, Giovannini S, Seo AY, et al. (2009). Molecular inflammation: underpinnings of aging and agerelated diseases. Ageing Res Rev 8:18-30.
33. Cochran DL (2008). Inflammation and bone loss in periodontal diseases. J Periodontol 79(8 Suppl):1569S-1576S.
34. Cohen H Y, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, et al. (2004). Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305:390-392. (Pubitemid 38938153)
35. Cross CE, Hasegawa G, Reddy KA, Omaye ST (1977). Enhanced lung toxicity of 02 in selenium-deficient rats. Res Commun Chem Pathol Pharmacol 16:695-706. (Pubitemid 8090413)
36. Csiszar A, Wang M, Lakatta EG, Ungvari Z (2008). Inflammation and endothelial dysfunction during aging: role of NF-kappaB. J Appl Physiol 105:1333-1341.
37. Del Fattore A, Cappariello A, Teti A (2008). Genetics, pathogenesis and complications of osteopetrosis. Bone 42:19-29. (Pubitemid 350297169)
38. Devaux B, Scholz D, Hirche A, Klovekorn WP, Schaper J (1997). Upregulation of cell adhesion molecules and the presence of low grade inflammation in human chronic heart failure. Eur Heart J 18:470-479. (Pubitemid 27110479)
39. Ershler WB, Keller ET (2000). Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annu Rev Med 51:245-270. (Pubitemid 30216036)
40. Feige JN, Auwerx J (2008). Transcriptional targets of sirtuins in the coordination of mammalian physiology. Curr Opin Cell Biol 20:303-309.
41. Feng L, Xia Y, Garcia GE, Hwang D, Wilson CB (1995). Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by interleukin-1 tumor necrosis factor-alpha and lipopolysaccharide. J Clin Invest 95:1669-1675.
42. Filiopoulos V, Vlassopoulos D (2009). Inflammatory syndrome in chronic kidney disease: pathogenesis and influence on outcomes. Inflamm Allergy Drug Targets 8:369-382.
43. Fisher GJ, Datta SC, Talwar HS, Wang ZQ, Varani J, Kang S, et al. (1996). Molecular basis of sun-induced premature skin ageing and retinoid antagonism. Nature 379:335-339. (Pubitemid 26033074)
44. Franceschi C (2007). Inflammaging as a major characteristic of old people: can it be prevented or cured? Nutr Rev 65(12 Pt 2):S173-S176.
45. Frescas D, Valenti L, Accili D (2005). Nuclear trapping of the forkhead transcription factor Fox01 via Sirt-dependent deacetylation promotes expression of glucogenetic genes. J Biol Chem 280:20589-20595. (Pubitemid 40776761)
46. Funaki M (2009). Saturated fatty acids and insulin resistance. J Med Invest 56:88-92.
47. Furugen R, Hayashida H, Yamaguchi N, Yoshihara A, Ogawa H, Miyazaki H, et al. (2008). The relationship between periodontal condition and serum levels of resistin and adiponectin in elderly Japanese. J Clin Periodontol 43:556-562.
48. Galgani JE, Uauy RD, Aguirre CA, Díaz EO (2008). Effect of the dietary fat quality on insulin sensitivity. Br J Nutr 100:471-479.
49. Galkina E, Ley K (2009). Immune and inflammatory mechanisms of atherosclerosis. Annu Rev Immunol 27:165-197.
50. Gangemi S, Pescara L, D'Urbano E, Basile G, Nicita-Mauro V, Davì G, et al. (2005). Aging is characterized by a profound reduction in antiinflammatory lipoxin A4 level. Exp Gerontol 40:612-614. (Pubitemid 41074808)
51. Ghosh HS (2008). The anti-aging, metabolism potential of SIRT1. Curr Opin Investig Drugs 9:1095-1102.
52. Ghosh S, Karin M (2002). Missing pieces in the NF-kappaB puzzle. Cell 109(Suppl):81-96.
53. Ginaldi L, Di Benedetto MC, De Martinis M (2005). Osteoporosis, inflammation and ageing. Immun Ageing 2:14.
54. Goldberg RB (2009). Cytokine and cytokine-like inflammation markers, endothelial dysfunction, and imbalanced coagulation in development of diabetes and its complications. J Clin Endocrinol Metab 94:3171-3182.
55. Handel ML, McMorrow LB, Gravallese EM (1995). Nuclear factor-kappa B in rheumatoid synovium. Localization of p50 and p65. Arthritis Rheum 38:1762-1770. (Pubitemid 26010277)
56. Havens AM, Chiu E, Taba M, Wang J, Shiozawa Y, Jung Y, et al. (2008). Stromal-derived factor-1alpha (CXCL12) levels increase in periodontal disease. J Periodontol 79:845-853.
57. Hayashi H, Yamaza H, Komatsu T, Park S, Chiba T, Higami Y, et al. (2008). Calorie restriction minimizes activation of insulin signaling in response to glucose: potential involvement of the growth hormone-insulin-like growth factor 1 axis. Exp Gerontol 43:827-832.
58. Hedrick SM (2009). The cunning little vixen: Foxo and the cycle of life and death. Nat Immunol 10:1057-1063.
59. Helenius M, Hanninen M, Lehtinen SK, Salminen A (1996). Aging induced up-regulation of nuclear binding activities of oxidative stress responsive NF-KB transcription factor in mouse cardiac muscle. J Mol Cell Cardiol 28:487-498.
60. Herrera MD, Mingorance C, Rodríguez-Rodríguez R, Alvarez de Sotomayor M (2010). Endothelial dysfunction and aging: an update. Ageing Res Rev 9:142-152.
61. Hewitt C, McCormick D, Linden G, Turk D, Stern I, Wallace I, et al. (2004). The role of cathepsin C in Papillon-Lefèvre syndrome, prepubertal periodontitis, and aggressive periodontitis. Hum Mutat 23:222-228. (Pubitemid 38337886)
62. Heydari AR, Richardson A (1992). Does gene expression play any role in the mechanism of the antiaging effect of dietary restriction? Ann NY Acad Sci 663:384-395. (Pubitemid 23090557)
63. Hijona E, Hijona L, Arenas JI, Bujanda L (2010). Inflammatory mediators of hepatic steatosis. Mediators Inflamm 2010:837419.
64. Hotamisligil GS (2010). Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 140:900-917.
65. Huttner EA, Machado DC, de Oliveira RB, Antunes AG, Hebling E (2009). Effects of human aging on periodontal tissues. Spec Care Dentist 29:149-155.
66. Jung KJ, Lee EK, Yu BP, Chung HY (2009a). Significance of protein tyrosine kinase/protein tyrosine phosphatase balance in the regulation of NF-kappaB signaling in the inflammatory process and aging. Free Radic Biol Med 47:983-991.
67. Jung KJ, Lee EK, Kim JY, Zou Y, Sung B, Heo HS, et al. (2009b). Effect of short term calorie restriction on pro-inflammatory NF-κB and AP-1 in aged rat kidney. Inflamm Res 58:143-150.
68. Kahn BB, Flier JS (2000). Obesity and insulin resistance. J Clin Invest 106:473-481. (Pubitemid 30666380)
69. Karthikeyan BV, Pradeep AR (2007). Gingival crevicular fluid and serum leptin: their relationship to periodontal health and disease. J Clin Periodontol 34:467-472.
70. Kim DH, Kim JY, Yu BP, Chung HY (2008). The activation of NF-κB through Akt-induced FOX01 phosphorylation during aging and its modulation by calorie restriction. Biogerontology 9:33-47.
71. Kim HJ, Kim KW, Yu BP, Chung HY (2000). The effect of age on cyclooxygenases-2 gene expression: NF-kappaB activation and IkappaBalpha degradation. Free Radic Biol Med 28:683-692.
72. Kim HJ, Jung KJ, Yu BP, Cho CG, Choi JS, Chung HY (2002). Modulation of redox-sensitive transcription factors by calorie restriction during aging. Mech Ageing Dev 123:1589-1595. (Pubitemid 35449222)
73. Kim HK, Park HR, Sul KH, Chung HY, Chung J (2006). Induction of RANTES and CCR5 through NF-kappaB activation via MAPK pathway in aged rat gingival tissues. Biotechnol Lett 28:17-23. (Pubitemid 41821486)
74. Kim HK, Park HR, Lee JS, Chung TS, Chung HY, Chung J (2007). Downregulation of iNOS and TNF-alpha expression by kaempferol via NF-kappaB inactivation in aged rat gingival tissues. Biogerontology 8:399-408. (Pubitemid 47054797)
75. Kim JW, Baek BS, Kim YK, Herlihy JT, Ikeno Y, Yu BP, et al. (2001). Gene expression of cyclooxygenase in the aging heart. J Gerontol A Biol Sci Med Sci 56:B350-355. (Pubitemid 32717781)
76. Kim KS, Kang KW, Seu YB, Baek SH, Kim JR (2009). Interferon-gamma induces cellular senescence through p53-dependent DNA damage signaling in human endothelial cells. Mech Ageing Dev 130:179-188.
77. Kirkwood KL, Rossa C Jr (2009). The potential of p38 MAPK inhibitors to modulate periodontal infections. Curr Drug Metab 10:55-67.
78. Kobayashi Y, Furukawa-Hibi Y, Chen C, Horio Y, Isobe K, Ikeda K, et al. (2005). SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress. Int J Mol Med 16:237-243.
79. Kops GJ, Dansen TB, Polderman PE, Saarloos I, Wirtz KW, Coffer PJ, et al. (2002). Forkhead transcription factor FOX03a protects quiescent cells from oxidative stress. Nature 419:316-321.
80. Korhonen P, Helenius M, Salminen A (1997). Age-related changes in the regulation of NF-kappa B in rat brain. Neurosci Lett 225:61-64. (Pubitemid 27154218)
81. Krabbe KS, Pedersen M, Bruunsgaard H (2004). Inflammatory mediators in the elderly. Exp Gerontol 39:687-699. (Pubitemid 38586809)
82. Kritchevsky SB, Cesari M, Pahor M (2005). Inflammatory markers and cardiovascular health in older adults. Cardiovasc Res 66:265-275. (Pubitemid 40471041)
83. Lawlor MA, Alessi DR (2001). PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? J Cell Sci 114(Pt 16):2903-2910. (Pubitemid 32821530)
84. Lerner U (2006). Inflammation-induced bone remodeling in periodontal disease and the influence of post-menopausal osteoporosis. J Dent Res 85:596-607. (Pubitemid 44085948)
85. Li Z, Froehlich J, Galis ZS, Lakatta EG (1999). Increased expression of matrix metalloproteinase-2 in the thickened intima of aged rats. Hypertension 33:116-123. (Pubitemid 29061851)
86. Liang S, Hosur KB, Domon H, Hajishengallis G (2010). Periodontal inflammation and bone loss in aged mice. J Periodontal Res 45:574-578.
87. Liu SL, Lin X, Shi DY, Cheng J, Wu CQ, Zhang YD (2002). Reactive oxygen species stimulated human hepatoma cell proliferation via cross-talk between PI3-K/PKB and JNK signaling pathways. Arch Biochem Biophys 406:173-182. (Pubitemid 35216343)
88. Lu L, Liu H, Peng J, Gan L, Shen L, Zhang Q, et al. (2010). Regulations of the key mediators in inflammation and atherosclerosis by aspirin in human macrophages. Lipids Health Dis 9:16.
89. Lykkesfeldt J, Hagen TM, Vinarsky V, Ames BN (1998). Age-associated decline in ascorbic acid concentration, recycling, and biosynthesis in rat hepatocytes-reversal with (R)-alpha-lipoic acid supplementation. FASEB J 12:1183-1189. (Pubitemid 28418948)
90. Maggio M, Guralnik JM, Longo DL, Ferrucci L (2006). Interleukin-6 in aging and chronic disease: a magnificent pathway. J Gerontol A Biol Sci Med Sci 61:575-584.
91. Mahmud DL, G-Amlak M, Deb DK, Platanias LC, Uddin S, Wickrema A (2002). Phosphorylation of forkhead transcription factors by erythropoietin and stem cell factor prevents acetylation and their interaction with coactivator p300 in erythroid progenitor cells. Oncogene 21:1556-1562. (Pubitemid 34226143)
92. Marinkovic D, Zhang X, Yalcin S, Luciano JP, Brugnara C, Huber T, et al. (2007). Fox03 is required for the regulation of oxidative stress in erythropoiesis. J Clin Invest 117:2133-2144. (Pubitemid 47219558)
93. Martelli-Junior H, Cotrim P, Graner E, Sauk JJ, Coletta RD (2003). Effect of transforming growth factor-beta1, interleukin-6, and interferongamma on the expression of type I collagen, heat shock protein 47, matrix metalloproteinase (MMP)-1 and MMP-2 by fibroblasts from normal gingiva and hereditary gingival fibromatosis. J Periodontol 74:296-306. (Pubitemid 36939343)
94. Masternak MM, Bartke A (2007). PPARs in calorie restricted and genetically long-lived mice. P PA R Res 2007:28436.
95. Matthews JB, Wright HJ, Roberts A, Cooper PR, Chapple IL (2007a). Hyperactivity and reactivity of peripheral blood neutrophils in chronic periodontitis. Clin Exp Immunol. 147:255-264. (Pubitemid 46096003)
96. Matthews JB, Wright HJ, Roberts A, Ling-Mountford N, Cooper PR, Chapple IL (2007b). Neutrophil hyper-responsiveness in periodontitis. J Dent Res. 86:718-722.
97. McCay CM, Crowell MF, Maynard LA (1935). The effect of retarded growth upon the length of life span upon the ultimate body size. J Nutrition 10:63-79.
98. McCormick RK (2007). Osteoporosis: integrating biomarkers and other diagnostic correlates into the management of bone fragility. Altern Med Rev 12:113-145. (Pubitemid 47169651)
99. McLean RR (2009). Proinflammatory cytokines and osteoporosis. Curr Osteoporos Rep 7:134-139.
100. Mura CV, Gong X, Taylor A, Villalobos-Molina R, Scrofano MM (1996). Effects of calorie restriction and aging on the expression of antioxidant enzymes and ubiquitin in the liver of Emory mice. Mech Ageing Dev 91:115-129. (Pubitemid 26358744)
101. Nagle CA, Klett EL, Coleman RA (2009). Hepatic triacylglycerol accumulation and insulin resistance. J Lipid Res 50(Suppl):74S-79S.
102. Nasrin N, Ogg S, Cahill CM, Biggs W, Nui S, Dore J, et al. (2000). DAF-16 recruits the CREB-binding protein coactivator complex to the insulinlike growth factor binding protein 1 promoter in HepG2 cells. Proc Natl Acad Sci USA 97:10412-10417.
103. Navab M, Gharavi N, Watson AD (2008). Inflammation and metabolic disorders. Curr Opin Clin Nutr Metab Care 11:459-464.
104. Nesbitt MJ, Reynolds MA, Shiau H, Choe K, Simonsick EM, Ferrucci L (2010). Association of periodontitis and metabolic syndrome in the Baltimore Longitudinal Study of Aging. Aging Clin Exp Res. 22:238-242.
105. Nishimura F, Murayama Y (2001). Periodontal inflammation and insulin resistance-lessons from obesity. J Dent Res 80:1690-1694. (Pubitemid 32931340)
106. Nisoli E, Tonello C, Cardile A, Cozzi V, Bracale R, Tedesco L, et al. (2005). Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science 310:314-317. (Pubitemid 41457197)
107. Parkkila S, Innocenti A, Kallio H, Hilvo M, Scozzafava A, Supuran CT (2009). The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms. Bioorg Med Chem Lett 19:4102-4106.
108. Picard F, Kurtev M, Chung N, Topark-Ngarm A, Senawong T, Machado de Oliveira R, et al. (2004). Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 429:771-776. (Pubitemid 38833129)
109. Pischon N, Heng N, Bernimoulin JP, Kleber BM, Willich SN, Pischon T (2007). Obesity, inflammation, and periodontal disease. J Dent Res 86:400-409.
110. Polyzos SA, Kountouras J, Zavos C (2009). Nonalcoholic fatty liver disease: the pathogenetic roles of insulin resistance and adipocytokines. Curr Mol Med 9:299-314.
111. Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, et al. (2003). Insulin-regulated hepatic gluconeogenesis through FOX01-PGC-1alpha interaction. Nature 423:550-555. (Pubitemid 36648580)
112. Ramirez-Tortosa MC, Quiles JL, Battino M, Granados S, Morillo JM, Bompadre S, et al. (2010). Periodontitis is associated with altered plasma fatty acids and cardiovascular risk markers. Nutr Metab Cardiovasc Dis 20:133-139.
113. Ridker PM (1998). Inflammation, infection, and cardiovascular risk: how good is the clinical evidence? Circulation 97:1671-1674. (Pubitemid 28211414)
114. Ridker PM, Stampfer MJ, Rifai N (2001). Novel risk factors for systemic atherosclerosis: a comparison of C-reactive protein, fibrinogen, homocysteine, lipoprotein (a), and standard cholesterol screening as predictors of peripheral arterial disease. J Am Med Assoc 285:2481-2485. (Pubitemid 32433842)
115. Rikans LE, DeCicco LA, Hornbrook KR, Yamano T (1999). Effect of age and carbon tetrachloride on cytokine concentrations in rat liver. Mech Ageing Dev 108:173-182. (Pubitemid 29258083)
116. Roth GS, Ingram DK, Joseph JA (2007). Nutritional interventions in aging and age-associated diseases. Ann NY Acad Sci 1114:369-371. (Pubitemid 350070414)
117. Roubenoff R, Harris TB, Abad LW, Wilson PW, Dallal GE, Dinarello CA (1998). Monocyte cytokine production in an elderly population: effect of age and inflammation. J Gerontol A Biol Sci Med Sci 53:M20-M26.
118. Salih DA, Brunet A (2008). FoxO transcription factors in the maintenance of cellular homeostasis during aging. Curr Opin Cell Biol 20:126-136.
119. Salminen A, Kaarniranta K (2010). Genetics vs entropy: longevity factors suppress the NF-κB-driven entropic aging process. Ageing Res Rev 9:298-314.
120. Sansoni P, Vescovini R, Fagnoni F, Biasini C, Zanni F, Zanlari L, et al. (2008). The immune system in extreme longevity. Exp Gerontol 43:61-65.
121. Saraiva M, O'Garra A (2010). The regulation of IL-10 production by immune cells. Nat Rev Immunol 10:170-181.
122. Sarsour EH, Kumar MG, Chaudhuri L, Kalen AL, Goswami PC (2009). Redox control of the cell cycle in health and disease. Antioxid Redox Signal 11:2985-3011.
123. Serhan CN (2007). Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways. AnnuRev Immunol 25:101-137. (Pubitemid 46697904)
124. Shimizu H, Nakagami H, Morita S, Tsukamoto I, Osako MK, Nakagami F, et al. (2009). New treatment of periodontal diseases by using NF-κB decoy oligodeoxynucleotides via prevention of bone resorption and promotion of wound healing. Antioxid Redox Signal 11:2065-2075.
125. Sinclair DA, Guarente L (1997). Extrachromosomal rDNA circles-a cause of aging in yeast. Cell 91:1033-1042. (Pubitemid 28027835)
126. Suganami T, Ogawa Y (2010). Adipose tissue macrophages: their role in adipose tissue remodeling. J Leukoc Biol 88:33-39.
127. Sung B, Park S, Yu BP, Chung HY (2004). Modulation of PPAR in aging, inflammation, and calorie restriction. J Gerontol A Biol Sci Med Sci 59:997-1006. (Pubitemid 39441788)
128. Sung B, Park S, Yu BP, Chung HY (2006). Amelioration of agerelated inflammation and oxidative stress by PPARgamma activator: suppression NF-kappaB by 2, 4-thiazolidinedione. Exp Gerontol 41:590-599. (Pubitemid 43867228)
129. Tardif F, Ross G, Rouabhia M (2004). Gingival and dermal fibroblasts produce interleukin-1 beta converting enzyme and interleukin-1 beta but not interleukin-18 even after stimulation with lipopolysaccharide. J Cell Physiol 198:125-132. (Pubitemid 38120973)
130. Tereshina EV (2009). Metabolic abnormalities as a basis for age-dependent diseases and aging? State of the art. Adv Gerontol 22:129-138.
131. Ungvari Z, Orosz Z, Labinskyy N, Rivera A, Xiangmin Z, Smith K, et al. (2007). Increased mitochondrial H2O2 production promotes endothelial NF-κB activation in aged rat arteries. Am J Physiol Heart Circ Physiol 293:H37-H47. (Pubitemid 47108162)
132. Van der Heide LP, Hoekman MF, Smidt MP (2004). The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation. Biochem J 380(Pt 2):297-309. (Pubitemid 38788101)
133. Wahli W (2002). Peroxisome proliferator-activated receptors (PPARs): from metabolic control to epidermal wound healing. Swiss Med Wkly 132:83-91. (Pubitemid 34492280)
134. Willette AA, Bendlin BB, McLaren DG, Canu E, Kastman EK, Kosmatka KJ, et al. (2010). Age-related changes in neural volume and microstructure associated with interleukin-6 are ameliorated by a calorie-restricted diet in old rhesus monkeys. Neuroimage 51:987-994.
135. Williams R, Offenbacher S (2000). Periodontal medicine: the emergence of a new branch of periodontology. Periodontol 23:9-12.
136. Xu J, Wu HF, Ang ES, Yip K, Woloszyn M, Zheng MH, et al. (2009). NF-kappaB modulators in osteolytic bone diseases. Cytokine Growth Factor Rev 20:7-17.
137. Yamaguchi N, Kukita T, Li YJ, Martinez Argueta JG, Saito T, Hanazawa S, et al. (2007). Adiponectin inhibits osteoclast formation stimulated by lipopolysaccharide from Actinobacillus actinomycetemcomitans. FEMS Immunol Med Microbiol 49:28-34. (Pubitemid 46160583)
138. Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, Frye RA, et al. (2004). Modulation of NFkappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J 23:2369-2380. (Pubitemid 38954844)
139. Yu BP (1996). Aging and oxidative stress: modulation by dietary restriction. Free Radic Biol Med 21:651-668. (Pubitemid 26331095)
140. Yu BP (2006). Why calorie restriction would work for human longevity. Biogerontology 7:179-182. (Pubitemid 44151630)
141. Yu BP, Chung HY (2001). Oxidative stress and vascular aging. Diabetes Res Clin Pract 54(Suppl 2):73-80.
142. Yu BP, Chung HY (2006). Adaptive mechanisms to oxidative stress during aging. Mech Ageing Dev 127:436-443.
143. Zou Y, Jung KJ, Kim JW, Yu BP, Chung HY (2004). Alteration of soluble adhesion molecules during aging and their modulation by calorie restriction. FASEB J 18:320-322.
144. Zou Y, Kim DH, Jung KJ, Heo HS, Kim CH, Baik HS, et al. (2009). Lysophosphatidylcholine enhances oxidative stress via the 5-lipoxygenase pathway in rat aorta during aging. Rejuvenation Res 12:15-24.