Saturated fatty acids and insulin resistance

Journal of Medical Investigation

Volumn 56, Issue 3-4, 2009, Pages 88-92

  Funaki, Makoto ^a,b  

^a TOKUSHIMA UNIVERSITY HOSPITAL   (Japan)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Adipocyte; Inflammation; Insulin resistance; Saturated fatty acid; White adipose tissue

Indexed keywords

ADIPOCYTOKINE; DIACYLGLYCEROL; FATTY ACID; GLYCEROL; I KAPPA B KINASE; INTERLEUKIN 6; LEPTIN; LIPOPROTEIN LIPASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE; SATURATED FATTY ACID; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 4; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; VERY LOW DENSITY LIPOPROTEIN;

CALORIC INTAKE; ENDOPLASMIC RETICULUM STRESS; ENERGY BALANCE; ENZYME ACTIVATION; FAT INTAKE; HUMAN; INSULIN RESISTANCE; LIPID STORAGE; LIPOHYPERTROPHY; MACROPHAGE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OXIDATIVE STRESS; PATHOPHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; WHITE ADIPOSE TISSUE;

EID: 70350028197     PISSN: 13431420     EISSN: None     Source Type: Journal    
DOI: 10.2152/jmi.56.88     Document Type: Review

References (42)

1. Neel JV, Weder AB, Julius S: Type II diabetes, essential hypertension, and obesity as "syndromes of impaired genetic homeostasis": the "thrifty genotype" hypothesis enters the 21st century. Perspect Biol Med 42: 44-74, 1998
2. Hajer GR, van Haeften TW, Visseren FL: Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur Heart J 29: 2959-2971, 2008
3. Miyoshi H, Perfield JW 2nd, Obin MS, Greenberg AS: Adipose triglyceride lipase regulates basal lipolysis and lipid droplet size in adipocytes. J Cell Biochem 105: 1430-1436, 2008
4. Kiess W, Petzold S, Topfer M, Garten A, Bluher S, Kapellen T, Korner A, Kratzsch J: Adipocytes and adipose tissue. Best Pract Res Clin Endocrinol Metab 22: 135-153, 2008
5. Lago F, Dieguez C, Gomez-Reino J, Gualillo O: Adipokines as emerging mediators of immune response and inflammation. Nat Clin Pract Rheumatol 3: 716-724, 2007
6. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, et al.: Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334: 292-295, 1996
7. Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, Mori Y, Ide T, Murakami K, Tsuboyama-Kasaoka N, Ezaki O, Akanuma Y, Gavrilova O, Vinson C, Reitman ML, Kagechika H, Shudo K, Yoda M, Nakano Y, Tobe K, Nagai R, Kimura S, Tomita M, Froguel P, Kadowaki T: The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7: 941-946, 2001
8. Saladin R, De Vos P, Guerre-Millo M, Leturque A, Girard J, Staels B, Auwerx J: Transient increase in obese gene expression after food intake or insulin administration. Nature 377: 527-529, 1995
9. Cheung CC, Clifton DK, Steiner RA: Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology 138: 4489-4492, 1997
10. Long YC, Zierath JR: AMP-activated protein kinase signaling in metabolic regulation. J Clin Invest 116: 1776-1783, 2006
11. Fruebis J, Tsao TS, Javorschi S, Ebbets-Reed D, Erickson MR, Yen FT, Bihain BE, Lodish HF: Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci U S A 98: 2005-2010, 2001
12. Kobayashi H, Ouchi N, Kihara S, Walsh K, Kumada M, Abe Y, Funahashi T, Matsuzawa Y: Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin. Circ Res 94: e27-31, 2004
13. Hara K, Horikoshi M, Yamauchi T, Yago H, Miyazaki O, Ebinuma H, Imai Y, Nagai R, Kadowaki T: Measurement of the high-molecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome. Diabetes Care 29: 1357-1362, 2006
14. Kadowaki T, Yamauchi T: Adiponectin and adiponectin receptors. Endocr Rev 26: 439-451, 2005
15. Schaffer JE: Lipotoxicity: when tissues overeat. Curr Opin Lipidol 14: 281-287, 2003
16. Unger RH, Orci L: Lipoapoptosis: its mechanism and its diseases. Biochim Biophys Acta 1585: 202-212, 2002
17. de Ferranti S, Mozaffarian D: The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences. Clin Chem 54: 945-955, 2008
18. Guilherme A, Virbasius JV, Puri V, Czech MP: Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol 9: 367-377, 2008
19. Elgazar-Carmon V, Rudich A, Hadad N, Levy R: Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding. J Lipid Res 49: 1894-1903, 2008
20. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr: Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112: 1796-1808, 2003
21. Cnop M: Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetes. Biochem Soc Trans 36: 348-352, 2008
22. Galgani JE, Uauy RD, Aguirre CA, Diaz EO: Effect of the dietary fat quality on insulin sensitivity. Br J Nutr 100: 471-479, 2008
23. Johnson L, Mander AP, Jones LR, Emmett PM, Jebb SA: Energy-dense, low-fiber, high-fat dietary pattern is associated with increased fatness in childhood. Am J Clin Nutr 87: 846-854, 2008
24. USDA: Composition of Foods Raw, Processed, Prepared. USDA National Nutrient Database for Standard Reference, Release 21 Available from: http://www.nal.usda.gov/fnic/foodcomp/Data/SR21/sr21_doc.pdf, 2008
25. Kien CL, Bunn JY, Ugrasbul F: Increasing dietary palmitic acid decreases fat oxidation and daily energy expenditure. Am J Clin Nutr 82: 320-326, 2005
26. Lobo S, Bernlohr DA: Fatty acid transport in adipocytes and the development of insulin resistance. Novartis Found Symp 286: 113-121; discussion 121-116, 162-113, 196-203, 2007
27. Su X, Abumrad NA: Cellular fatty acid uptake: a pathway under construction. Trends Endocrinol Metab 20: 72-77, 2009
28. Gao Z, Zhang X, Zuberi A, Hwang D, Quon MJ, Lefevre M, Ye J: Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes. Mol Endocrinol 18: 2024-2034, 2004
29. Haversen L, Danielsson KN, Fogelstrand L, Wiklund O: Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages. Atherosclerosis 202: 382-393, 2009
30. Subauste AR, Burant CF: Role of FoxO1 in FFA-induced oxidative stress in adipocytes. Am J Physiol Endocrinol Metab 293: E159-164, 2007
31. Lin Y, Berg AH, Iyengar P, Lam TK, Giacca A, Combs TP, Rajala MW, Du X, Rollman B, Li W, Hawkins M, Barzilai N, Rhodes CJ, Fantus IG, Brownlee M, Scherer PE: The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species. J Biol Chem 280: 4617-4626, 2005
32. Song MJ, Kim KH, Yoon JM, Kim JB: Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes. Biochem Biophys Res Commun 346: 739-745, 2006
33. Suganami T, Tanimoto-Koyama K, Nishida J, Itoh M, Yuan X, Mizuarai S, Kotani H, Yamaoka S, Miyake K, Aoe S, Kamei Y, Ogawa Y: Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages. Arterioscler Thromb Vasc Biol 27: 84-91, 2007
34. Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS: TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 116: 3015-3025, 2006
35. Lee JS, Pinnamaneni SK, Eo SJ, Cho IH, Pyo JH, Kim CK, Sinclair AJ, Febbraio MA, Watt MJ: Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites. J Appl Physiol 100: 1467-1474, 2006
36. Reynoso R, Salgado LM, Calderon V: High levels of palmitic acid lead to insulin resistance due to changes in the level of phosphorylation of the insulin receptor and insulin receptor substrate-1. Mol Cell Biochem 246: 155-162, 2003
37. Schenk S, Saberi M, Olefsky JM: Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest 118: 2992-3002, 2008
38. Sinha S, Perdomo G, Brown NF, O'Doherty RM: Fatty acid-induced insulin resistance in L6 myotubes is prevented by inhibition of activation and nuclear localization of nuclear factor kappa B. J Biol Chem 279: 41294-41301, 2004
39. Reyna SM, Ghosh S, Tantiwong P, Meka CS, Eagan P, Jenkinson CP, Cersosimo E, Defronzo RA, Coletta DK, Sriwijitkamol A, Musi N: Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects. Diabetes 57: 2595-2602, 2008
40. Jue T, Rothman DL, Shulman GI, Tavitian BA, DeFronzo RA, Shulman RG: Direct observation of glycogen synthesis in human muscle with 13C NMR. Proc Natl Acad Sci USA 86: 4489-4491, 1989
41. Capeau J: Insulin resistance and steatosis in humans. Diabetes Metab 34: 649-657, 2008
42. Malhi H, Bronk SF, Werneburg NW, Gores GJ: Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis. J Biol Chem 281: 12093-12101, 2006