-
1
-
-
0022499547
-
Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin
-
Hirano T, Yasukawa K, Harada H, et al. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature. 1986;324:73-76.
-
(1986)
Nature
, vol.324
, pp. 73-76
-
-
Hirano, T.1
Yasukawa, K.2
Harada, H.3
-
2
-
-
0023685762
-
Cloning and expression of the human interleukin-6 (USF-2/IFN beta 2) receptor
-
Yamasaki K, Taga T, Hirata Y, et al. Cloning and expression of the human interleukin-6 (USF-2/IFN beta 2) receptor. Science. 1988;241:825-828.
-
(1988)
Science
, vol.241
, pp. 825-828
-
-
Yamasaki, K.1
Taga, T.2
Hirata, Y.3
-
3
-
-
0025630163
-
Molecular cloning and expression of an IL-6 signal transducer, gp130
-
Hibi M, Murakami M, Saito M, Hirano T, Taga T, Kishimoto T. Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell. 1990;63:1149-1157.
-
(1990)
Cell
, vol.63
, pp. 1149-1157
-
-
Hibi, M.1
Murakami, M.2
Saito, M.3
Hirano, T.4
Taga, T.5
Kishimoto, T.6
-
4
-
-
0027503291
-
Interleukin-6: A cytokine for gerontologists
-
Ershler WB. Interleukin-6: a cytokine for gerontologists. J Am Geriatr Soc. 1993;41:176-181.
-
(1993)
J Am Geriatr Soc
, vol.41
, pp. 176-181
-
-
Ershler, W.B.1
-
5
-
-
16344378434
-
Inflammatory markers and cardiovascular health in older adults
-
Kritchevsky SB, Cesari M, Pahor M. Inflammatory markers and cardiovascular health in older adults. Cardiovasc Res. 2005;66:265-275.
-
(2005)
Cardiovasc Res
, vol.66
, pp. 265-275
-
-
Kritchevsky, S.B.1
Cesari, M.2
Pahor, M.3
-
7
-
-
0034051068
-
Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty
-
Ershler WB, Keller ET. Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annu Rev Med 2000;51:245-270.
-
(2000)
Annu Rev Med
, vol.51
, pp. 245-270
-
-
Ershler, W.B.1
Keller, E.T.2
-
8
-
-
0028176556
-
Signal transduction through gp130 that is shared among the receptors for the interleukin 6 related cytokine subfamily
-
Hirano T, Matsuda T, Nakajima K. Signal transduction through gp130 that is shared among the receptors for the interleukin 6 related cytokine subfamily. Stem Cells. 1994;12:262-277.
-
(1994)
Stem Cells
, vol.12
, pp. 262-277
-
-
Hirano, T.1
Matsuda, T.2
Nakajima, K.3
-
9
-
-
20944433054
-
IL-6 and its circadian secretion in humans
-
Vgontzas AN, Bixler EO, Lin HM, Prolo P, Trakada G, Chrousos GP. IL-6 and its circadian secretion in humans. Neuroimmunomodulation. 2005;12:131-140.
-
(2005)
Neuroimmunomodulation
, vol.12
, pp. 131-140
-
-
Vgontzas, A.N.1
Bixler, E.O.2
Lin, H.M.3
Prolo, P.4
Trakada, G.5
Chrousos, G.P.6
-
10
-
-
0029052335
-
Induction of interleukin 6 (IL-6) by hypoxia in vascular cells. Central role of the binding site for nuclear factor-IL-6
-
Yan SF, Tritto I, Pinsky D, et al. Induction of interleukin 6 (IL-6) by hypoxia in vascular cells. Central role of the binding site for nuclear factor-IL-6. J Biol Chem. 1995;270:11463-11471.
-
(1995)
J Biol Chem
, vol.270
, pp. 11463-11471
-
-
Yan, S.F.1
Tritto, I.2
Pinsky, D.3
-
11
-
-
0030663526
-
Hypoxemia increases serum interleukin-6 in humans
-
Klausen T, Olsen NV, Poulsen TD, Richalet JP, Pedersen BK. Hypoxemia increases serum interleukin-6 in humans. Eur J Appl Physiol Occup Physiol. 1997;76:480-482.
-
(1997)
Eur J Appl Physiol Occup Physiol
, vol.76
, pp. 480-482
-
-
Klausen, T.1
Olsen, N.V.2
Poulsen, T.D.3
Richalet, J.P.4
Pedersen, B.K.5
-
12
-
-
0036781052
-
NF-kappaB regulation in the immune system
-
Li Q, Verma IM. NF-kappaB regulation in the immune system. Nat Rev Immunol. 2002;2:725-734.
-
(2002)
Nat Rev Immunol
, vol.2
, pp. 725-734
-
-
Li, Q.1
Verma, I.M.2
-
13
-
-
0026682873
-
Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo
-
Saito M, Yoshida K, Hibi M, Taga T, Kishimoto T. Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo. J Immunol. 1992;148:4066-4071.
-
(1992)
J Immunol
, vol.148
, pp. 4066-4071
-
-
Saito, M.1
Yoshida, K.2
Hibi, M.3
Taga, T.4
Kishimoto, T.5
-
14
-
-
0027499295
-
Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6
-
Nakajima T, Kinoshita S, Sasagawa T, et al. Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. Proc Natl Acad Sci U S A. 1993;90:2207-2211.
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 2207-2211
-
-
Nakajima, T.1
Kinoshita, S.2
Sasagawa, T.3
-
15
-
-
0032168152
-
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
-
Heinrich PC, Behrmann I, Muller-Newen G, Schaper F, Graeve L. Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem J. 1998;334:297-314.
-
(1998)
Biochem J
, vol.334
, pp. 297-314
-
-
Heinrich, P.C.1
Behrmann, I.2
Muller-Newen, G.3
Schaper, F.4
Graeve, L.5
-
16
-
-
0029084805
-
Interleukin-6 family of cytokines and gp130
-
Kishimoto T, Akira S, Narazaki M, Taga T. Interleukin-6 family of cytokines and gp130. Blood. 1995;86:1243-1254.
-
(1995)
Blood
, vol.86
, pp. 1243-1254
-
-
Kishimoto, T.1
Akira, S.2
Narazaki, M.3
Taga, T.4
-
17
-
-
0024851086
-
Regulation of interleukin 6 receptor expression in human monocytes and monocyte-derived macrophages. Comparison with the expression in human hepatocytes
-
Bauer J, Bauer TM, Kalb T, et al. Regulation of interleukin 6 receptor expression in human monocytes and monocyte-derived macrophages. Comparison with the expression in human hepatocytes. J Exp Med. 1989;170:1537-1549.
-
(1989)
J Exp Med
, vol.170
, pp. 1537-1549
-
-
Bauer, J.1
Bauer, T.M.2
Kalb, T.3
-
18
-
-
0027398766
-
The soluble interleukin-6 receptor is generated by shedding
-
Mullberg J, Schooltink H, Stoyan T, et al. The soluble interleukin-6 receptor is generated by shedding. Eur J Immunol. 1993;23:473-480.
-
(1993)
Eur J Immunol
, vol.23
, pp. 473-480
-
-
Mullberg, J.1
Schooltink, H.2
Stoyan, T.3
-
19
-
-
0030760235
-
Concentrations and origins of soluble interleukin 6 receptor-alpha in serum and synovial fluid
-
Desgeorges A, Gabay C, Silacci P, et al. Concentrations and origins of soluble interleukin 6 receptor-alpha in serum and synovial fluid. J Rheumatol. 1997;24:1510-1516.
-
(1997)
J Rheumatol
, vol.24
, pp. 1510-1516
-
-
Desgeorges, A.1
Gabay, C.2
Silacci, P.3
-
20
-
-
0033080801
-
C-reactive protein: A physiological activator of interleukin 6 receptor shedding
-
Jones SA, Novick D, Horiuchi S, Yamamoto N, Szalai AJ, Fuller GM. C-reactive protein: a physiological activator of interleukin 6 receptor shedding. J Exp Med. 1999;189:599-604.
-
(1999)
J Exp Med
, vol.189
, pp. 599-604
-
-
Jones, S.A.1
Novick, D.2
Horiuchi, S.3
Yamamoto, N.4
Szalai, A.J.5
Fuller, G.M.6
-
21
-
-
0036772859
-
Chemotactic agents induce IL-6R alpha shedding from polymorphonuclear cells: Involvement of a metalloproteinase of the TNF-alpha-converting enzyme (TACE) type
-
Marin V, Montero-Julian F, Gres S, Bongrand P, Farnarier C, Kaplanski G. Chemotactic agents induce IL-6R alpha shedding from polymorphonuclear cells: involvement of a metalloproteinase of the TNF-alpha-converting enzyme (TACE) type. Eur J Immunol. 2002;32:2965-2970.
-
(2002)
Eur J Immunol
, vol.32
, pp. 2965-2970
-
-
Marin, V.1
Montero-Julian, F.2
Gres, S.3
Bongrand, P.4
Farnarier, C.5
Kaplanski, G.6
-
22
-
-
0141866756
-
Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)
-
Matthews V, Schuster B, Schutze S, et al. Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE). J Biol Chem. 2003;278:38829-38839.
-
(2003)
J Biol Chem
, vol.278
, pp. 38829-38839
-
-
Matthews, V.1
Schuster, B.2
Schutze, S.3
-
23
-
-
0028799113
-
A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNK receptor
-
Mullberg J, Durie FH, Otten-Evans C, et al. A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNK receptor. J Immunol. 1995;155:5198-5205.
-
(1995)
J Immunol
, vol.155
, pp. 5198-5205
-
-
Mullberg, J.1
Durie, F.H.2
Otten-Evans, C.3
-
24
-
-
0037064542
-
The role of soluble receptors in cytokine biology: The agonistic properties of the sIL-6R/IL-6 complex
-
Jones SA, Rose-John S. The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex. Biochim Biophys Acta. 2002;1592:251-263.
-
(2002)
Biochim Biophys Acta
, vol.1592
, pp. 251-263
-
-
Jones, S.A.1
Rose-John, S.2
-
25
-
-
0027293104
-
Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130
-
Narazaki M, Yasukawa K, Saito T, et al. Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130. Blood. 1993;82:1120-1126.
-
(1993)
Blood
, vol.82
, pp. 1120-1126
-
-
Narazaki, M.1
Yasukawa, K.2
Saito, T.3
-
26
-
-
0035160256
-
Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses
-
Jostock T, Mullberg J, Ozbek S, et al. Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses. Eur J Biochem. 2001;268:160-167.
-
(2001)
Eur J Biochem
, vol.268
, pp. 160-167
-
-
Jostock, T.1
Mullberg, J.2
Ozbek, S.3
-
28
-
-
0032846613
-
Novel path to activation of vascular smooth muscle cells: Up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor
-
Klouche M, Bhakdi S, Hemmes M, Rose-John S. Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor. J Immunol. 1999;163:4583-589.
-
(1999)
J Immunol
, vol.163
, pp. 4583-4589
-
-
Klouche, M.1
Bhakdi, S.2
Hemmes, M.3
Rose-John, S.4
-
29
-
-
0035378160
-
The soluble IL-6 receptors: Serum levels and biological function
-
Montero-Julian FA. The soluble IL-6 receptors: serum levels and biological function. Cell Mol Biol. 2001;47:583-597.
-
(2001)
Cell Mol Biol
, vol.47
, pp. 583-597
-
-
Montero-Julian, F.A.1
-
30
-
-
0038642195
-
IL-6 type cytokine receptor complexes: Hexamer, tetramer or both?
-
Grotzinger J, Kernebeck T, Kallen KJ, Rose-John S. IL-6 type cytokine receptor complexes: hexamer, tetramer or both? Biol Chem. 1999;380:803-813.
-
(1999)
Biol Chem
, vol.380
, pp. 803-813
-
-
Grotzinger, J.1
Kernebeck, T.2
Kallen, K.J.3
Rose-John, S.4
-
31
-
-
1642578987
-
IL-6 trans-signaling: The heat is on
-
Rose-John S, Neurath MF. IL-6 trans-signaling: the heat is on. Immunity. 2004;20:2-4.
-
(2004)
Immunity
, vol.20
, pp. 2-4
-
-
Rose-John, S.1
Neurath, M.F.2
-
32
-
-
18344410191
-
Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo
-
200
-
Atreya R, Mudter J, Finotto S, et al. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn disease and experimental colitis in vivo. Nat Med. 200;6:583-588.
-
Nat Med
, vol.6
, pp. 583-588
-
-
Atreya, R.1
Mudter, J.2
Finotto, S.3
-
33
-
-
11144358366
-
A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease
-
Ito H, Takazoe M, Fukuda Y, et al. A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease. Gastroenterology. 2004;126:989-096.
-
(2004)
Gastroenterology
, vol.126
, pp. 989-1096
-
-
Ito, H.1
Takazoe, M.2
Fukuda, Y.3
-
34
-
-
0033545342
-
Acute-phase proteins and other systemic responses to inflammation
-
Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med. 1999;340:448-454.
-
(1999)
N Engl J Med
, vol.340
, pp. 448-454
-
-
Gabay, C.1
Kushner, I.2
-
35
-
-
0025190892
-
Interleukin-6 and the acute phase response
-
Heinrich PC, Castell JV, Andus T. Interleukin-6 and the acute phase response. Biochem J. 1990;265:621-636.
-
(1990)
Biochem J
, vol.265
, pp. 621-636
-
-
Heinrich, P.C.1
Castell, J.V.2
Andus, T.3
-
36
-
-
0035164602
-
The soluble interleukin 6 receptor: Mechanisms of production and implications in disease
-
Jones SA, Horiuchi S, Topley N, Yamamoto N, Fuller GM. The soluble interleukin 6 receptor: mechanisms of production and implications in disease. FASEB J. 2001;15:43-58.
-
(2001)
FASEB J
, vol.15
, pp. 43-58
-
-
Jones, S.A.1
Horiuchi, S.2
Topley, N.3
Yamamoto, N.4
Fuller, G.M.5
-
37
-
-
0037064550
-
The role of transsignalling via the agonistic soluble IL-6 receptor in human diseases
-
Kallen KJ. The role of transsignalling via the agonistic soluble IL-6 receptor in human diseases. Biochem Biophys Acta. 2002;1592:323-343.
-
(2002)
Biochem Biophys Acta
, vol.1592
, pp. 323-343
-
-
Kallen, K.J.1
-
38
-
-
0032518415
-
IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses
-
Xing Z, Gauldie J, Cox G, et al. IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. J Clin Invest. 1998;101:311-320.
-
(1998)
J Clin Invest
, vol.101
, pp. 311-320
-
-
Xing, Z.1
Gauldie, J.2
Cox, G.3
-
39
-
-
0025176658
-
Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF
-
Schindler R, Mancilla J, Endres S, Ghorbani R, Clark SC, Dinarello CA. Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF. Blood. 1990;75:40-47.
-
(1990)
Blood
, vol.75
, pp. 40-47
-
-
Schindler, R.1
Mancilla, J.2
Endres, S.3
Ghorbani, R.4
Clark, S.C.5
Dinarello, C.A.6
-
40
-
-
0028031990
-
Interleukin-6 (IL-6) as an anti-inflammatory cytokine: Induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55
-
Tilg H, Trehu E, Atkins MB, Dinarello CA, Mier JW. Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55. Blood. 1994;83:113-118.
-
(1994)
Blood
, vol.83
, pp. 113-118
-
-
Tilg, H.1
Trehu, E.2
Atkins, M.B.3
Dinarello, C.A.4
Mier, J.W.5
-
41
-
-
24744435772
-
Directing transition from innate to acquired immunity: Defining a role for IL-6
-
Jones SA. Directing transition from innate to acquired immunity: defining a role for IL-6. J Immunol. 2005;175:3463-3468.
-
(2005)
J Immunol
, vol.175
, pp. 3463-3468
-
-
Jones, S.A.1
-
42
-
-
0027516460
-
Protective role of interleukin 6 in the lipopolysaccharide-galactosamine septic shock model
-
Barton BE, Jackson JV. Protective role of interleukin 6 in the lipopolysaccharide-galactosamine septic shock model. Infect Immun. 1993;61:1496-1499.
-
(1993)
Infect Immun
, vol.61
, pp. 1496-1499
-
-
Barton, B.E.1
Jackson, J.V.2
-
43
-
-
0026497223
-
Increase of plasma IL-6 concentration with age in healthy subjects
-
Wei J, Xu H, Davies JL, Hemmings GP. Increase of plasma IL-6 concentration with age in healthy subjects. Life Sci. 1992;51:1953-1956.
-
(1992)
Life Sci
, vol.51
, pp. 1953-1956
-
-
Wei, J.1
Xu, H.2
Davies, J.L.3
Hemmings, G.P.4
-
44
-
-
0027161033
-
Interleukin-6 and aging: Blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction
-
Ershler WB, Sun WH, Binkley N, et al. Interleukin-6 and aging: blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction. Lymphokine Cytokine Res. 1993;12:225-230.
-
(1993)
Lymphokine Cytokine Res
, vol.12
, pp. 225-230
-
-
Ershler, W.B.1
Sun, W.H.2
Binkley, N.3
-
45
-
-
0027973679
-
Interleukin-6 and selected plasma proteins in healthy persons of different ages
-
Hager K, Machein U, Krieger S, Platt D, Seefried G, Bauer J. Interleukin-6 and selected plasma proteins in healthy persons of different ages. Neurobiol Aging. 1994;15:771-772.
-
(1994)
Neurobiol Aging
, vol.15
, pp. 771-772
-
-
Hager, K.1
Machein, U.2
Krieger, S.3
Platt, D.4
Seefried, G.5
Bauer, J.6
-
46
-
-
0028088001
-
Circulating levels of cytokines that modulate bone resorption: Effects of age and menopause in women
-
McKane WR, Khosla S, Peterson JM, Egan K, Riggs BL. Circulating levels of cytokines that modulate bone resorption: effects of age and menopause in women. J Bone Miner Res. 1994;9:1313-1318.
-
(1994)
J Bone Miner Res
, vol.9
, pp. 1313-1318
-
-
McKane, W.R.1
Khosla, S.2
Peterson, J.M.3
Egan, K.4
Riggs, B.L.5
-
47
-
-
0028903358
-
Elevated plasma levels of interleukin-6 in postmenopausal women do not correlate with bone density
-
Kania DM, Binkley N, Checovich M, Havighurst T, Schilling M, Ershler WB. Elevated plasma levels of interleukin-6 in postmenopausal women do not correlate with bone density. J Am Geriatr Soc. 1995;43:236-239.
-
(1995)
J Am Geriatr Soc
, vol.43
, pp. 236-239
-
-
Kania, D.M.1
Binkley, N.2
Checovich, M.3
Havighurst, T.4
Schilling, M.5
Ershler, W.B.6
-
48
-
-
0030849677
-
The association of plasma IL-6 levels with functional disability in community-dwelling elderly
-
Cohen HJ, Pieper CF, Harris T, Rao KM, Currie MS. The association of plasma IL-6 levels with functional disability in community-dwelling elderly. J Gerontol A Biol Sci Med Sci. 1997;52A:M201-M208.
-
(1997)
J Gerontol a Biol Sci Med Sci
, vol.52 A
-
-
Cohen, H.J.1
Pieper, C.F.2
Harris, T.3
Rao, K.M.4
Currie, M.S.5
-
49
-
-
0033134682
-
Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly
-
Harris TB, Ferrucci L, Tracy RP, et al. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med. 1999;106:506-512.
-
(1999)
Am J Med
, vol.106
, pp. 506-512
-
-
Harris, T.B.1
Ferrucci, L.2
Tracy, R.P.3
-
50
-
-
15244348518
-
The origins of age-related proinflammatory state
-
Ferrucci L, Corsi A, Lauretani F, et al. The origins of age-related proinflammatory state. Blood. 2005;105:2294-2299.
-
(2005)
Blood
, vol.105
, pp. 2294-2299
-
-
Ferrucci, L.1
Corsi, A.2
Lauretani, F.3
-
51
-
-
16844384831
-
IL-6 gene variation is not associated with increased serum levels of IL-6, muscle, weakness, or frailty in older women
-
Walston J, Arking DE, Fallin D, et al. IL-6 gene variation is not associated with increased serum levels of IL-6, muscle, weakness, or frailty in older women. Exp Gerontol. 2005;40:344-352.
-
(2005)
Exp Gerontol
, vol.40
, pp. 344-352
-
-
Walston, J.1
Arking, D.E.2
Fallin, D.3
-
52
-
-
28144461360
-
Molecular mechanisms of aging-associated inflammation
-
Jun 21; [Epub ahead of print]
-
Sarkar D, Fisher P. Molecular mechanisms of aging-associated inflammation. Cancer Lett. 2005 Jun 21; [Epub ahead of print].
-
(2005)
Cancer Lett
-
-
Sarkar, D.1
Fisher, P.2
-
53
-
-
0035093402
-
Serum interleukin-6, soluble interleukin-6 receptor and soluble gp130 exhibit different patterns of age- and menopause-related changes
-
Giuliani N, Sansoni P, Girasole G, et al. Serum interleukin-6, soluble interleukin-6 receptor and soluble gp130 exhibit different patterns of age- and menopause-related changes. Exp Gerontol. 2001;36:547-557.
-
(2001)
Exp Gerontol
, vol.36
, pp. 547-557
-
-
Giuliani, N.1
Sansoni, P.2
Girasole, G.3
-
54
-
-
23044499225
-
Interleukin-6 acts as insulin sensitizer on glycogen synthesis in human skeletal muscle cells by phosphorylation of Ser473 of Akt
-
Weigert C, Hennige AM, Brodbeck K, Haring HU, Schleicher ED. Interleukin-6 acts as insulin sensitizer on glycogen synthesis in human skeletal muscle cells by phosphorylation of Ser473 of Akt. Am J Physiol Endocrinol Metab. 2005;289:E251-E257.
-
(2005)
Am J Physiol Endocrinol Metab
, vol.289
-
-
Weigert, C.1
Hennige, A.M.2
Brodbeck, K.3
Haring, H.U.4
Schleicher, E.D.5
-
55
-
-
33646350774
-
Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells
-
Jan 17; [Epub ahead of print]
-
Weigert C, Hennige AM, Lehmann R, et al. Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells. Biol Chem. 2006 Jan 17; [Epub ahead of print].
-
(2006)
Biol Chem
-
-
Weigert, C.1
Hennige, A.M.2
Lehmann, R.3
-
56
-
-
0030735542
-
Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo
-
Mohamed-Ali V, Goodrick S, Rawesh A, et al. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. J Clin Endocrinol Metab. 1997;82:4196-4200.
-
(1997)
J Clin Endocrinol Metab
, vol.82
, pp. 4196-4200
-
-
Mohamed-Ali, V.1
Goodrick, S.2
Rawesh, A.3
-
57
-
-
0031762908
-
Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: Depot difference and regulation by glucocorticoid
-
Fried SK, Bunkin DA, Greenberg AS. Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab. 1998;83:847-850.
-
(1998)
J Clin Endocrinol Metab
, vol.83
, pp. 847-850
-
-
Fried, S.K.1
Bunkin, D.A.2
Greenberg, A.S.3
-
58
-
-
12144291184
-
Diverse effect of inflammatory markers on insulin resistance and insulin-resistance syndrome in the elderly
-
Abbatecola A, Ferrucci L, Grella R, et al. Diverse effect of inflammatory markers on insulin resistance and insulin-resistance syndrome in the elderly. J Am Geriatr Soc. 2004;52:399-404.
-
(2004)
J Am Geriatr Soc
, vol.52
, pp. 399-404
-
-
Abbatecola, A.1
Ferrucci, L.2
Grella, R.3
-
59
-
-
0037853260
-
Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependentbinsulin resistance in hepatocytes
-
Senn JJ, Klover PJ, Nowak IA, et al. Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependentbinsulin resistance in hepatocytes. J Biol Chem. 2003;278:13740-13746.
-
(2003)
J Biol Chem
, vol.278
, pp. 13740-13746
-
-
Senn, J.J.1
Klover, P.J.2
Nowak, I.A.3
-
60
-
-
0037012406
-
Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: Role of fat and carbohydrate meals
-
Nappo F, Esposito K, Cioffi M, et al. Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: role of fat and carbohydrate meals. J Am Coll Cardiol. 2002;39:1145-1150.
-
(2002)
J Am Coll Cardiol
, vol.39
, pp. 1145-1150
-
-
Nappo, F.1
Esposito, K.2
Cioffi, M.3
-
61
-
-
27644439098
-
Proinflammatory state and circulating erythropoietin in persons with and without anemia
-
Ferrucci L, Guralnik JM, Woodman RC, et al. Proinflammatory state and circulating erythropoietin in persons with and without anemia. Am J Med. 2005;118:1288.
-
(2005)
Am J Med
, vol.118
, pp. 1288
-
-
Ferrucci, L.1
Guralnik, J.M.2
Woodman, R.C.3
-
62
-
-
4544288392
-
Effect of a Mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: A randomized trial
-
Esposito K, Marfella R, Ciotola M, et al. Effect of a Mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial. JAMA. 2004;292:1440-1446.
-
(2004)
JAMA
, vol.292
, pp. 1440-1446
-
-
Esposito, K.1
Marfella, R.2
Ciotola, M.3
-
63
-
-
15444374348
-
The anti-inflammatory effect of exercise
-
Petersen AM, Pedersen BK. The anti-inflammatory effect of exercise. J Appl Physiol. 2005;98:1154-1662.
-
(2005)
J Appl Physiol
, vol.98
, pp. 1154-1662
-
-
Petersen, A.M.1
Pedersen, B.K.2
-
64
-
-
21144432015
-
Association between physical activity, physical performance, and inflammatory biomarkers in an elderly population: The InCHIANTI study
-
Elosua R, Bartali B, Ordovas JM, Corsi AM, Lauretani F, Ferrucci L; InCHIANTI Investigators. Association between physical activity, physical performance, and inflammatory biomarkers in an elderly population: the InCHIANTI study. J Gerontol A Biol Sci Med Sci. 2005;60A:760-767.
-
(2005)
J Gerontol A Biol Sci Med Sci
, vol.60
, pp. 760-767
-
-
Elosua, R.1
Bartali, B.2
Ordovas, J.M.3
Corsi, A.M.4
Lauretani, F.5
Ferrucci, L.6
-
65
-
-
33745195533
-
Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects
-
Dec 13; [Epub ahead of print]
-
Bruun JM, Helge JW, Richelsen B, Stallknecht B. Diet and Exercise Reduce Low-grade Inflammation and Macrophage Infiltration in Adipose Tissue but not in Skeletal Muscle in Severely Obese Subjects. Am J Physiol Endocrinol Metab. 2005; Dec 13; [Epub ahead of print].
-
(2005)
Am J Physiol Endocrinol Metab
-
-
Bruun, J.M.1
Helge, J.W.2
Richelsen, B.3
Stallknecht, B.4
-
66
-
-
0033790375
-
Gp130 Cytokine family and bone cells
-
Heymann D, Rousselle AV. gp130 Cytokine family and bone cells. Cytokine. 2000;12:1455-1468.
-
(2000)
Cytokine
, vol.12
, pp. 1455-1468
-
-
Heymann, D.1
Rousselle, A.V.2
-
67
-
-
0028786577
-
Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors
-
Udagawa N, Takahashi N, Katagiri T, et al. Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors. J Exp Med. 1995;182:1461-1468.
-
(1995)
J Exp Med
, vol.182
, pp. 1461-1468
-
-
Udagawa, N.1
Takahashi, N.2
Katagiri, T.3
-
68
-
-
0028064978
-
Interleukin 6 production in fetal rat long bone cultures is correlated with PGE2 release and does not correlate with the extent of bone resorption
-
Bertolini DR, Votta B, Hoffman S, Strassmann G. Interleukin 6 production in fetal rat long bone cultures is correlated with PGE2 release and does not correlate with the extent of bone resorption. Cytokine. 1994;6:368-375.
-
(1994)
Cytokine
, vol.6
, pp. 368-375
-
-
Bertolini, D.R.1
Votta, B.2
Hoffman, S.3
Strassmann, G.4
-
69
-
-
0025259989
-
IL-6 is produced by osteoblasts and induces bone resorption
-
Ishimi Y, Miyaura C, Jin CH, et al. IL-6 is produced by osteoblasts and induces bone resorption. J Immunol. 1990;145:3297-3303.
-
(1990)
J Immunol
, vol.145
, pp. 3297-3303
-
-
Ishimi, Y.1
Miyaura, C.2
Jin, C.H.3
-
70
-
-
0029088925
-
Endogenous bone-resorbing factors in estrogen deficiency: Cooperative effects of IL-1 and IL-6
-
Miyaura C, Kusano K, Masuzawa T, et al. Endogenous bone-resorbing factors in estrogen deficiency: cooperative effects of IL-1 and IL-6. J Bone Miner Res. 1995;10:1365-1373.
-
(1995)
J Bone Miner Res
, vol.10
, pp. 1365-1373
-
-
Miyaura, C.1
Kusano, K.2
Masuzawa, T.3
-
71
-
-
0032739969
-
Aging and cytokine production
-
Pacifici R. Aging and cytokine production. Calcif Tissue Int. 1999;65:345-351.
-
(1999)
Calcif Tissue Int
, vol.65
, pp. 345-351
-
-
Pacifici, R.1
-
72
-
-
2342619696
-
Interactions of interleukin-6 promoter polymorphisms with dietary and lifestyle factors and their association with bone mass in men and women from the Framingham Osteoporosis Study
-
Ferrari SL, Karasik D, Liu J, et al. Interactions of interleukin-6 promoter polymorphisms with dietary and lifestyle factors and their association with bone mass in men and women from the Framingham Osteoporosis Study. J Bone Miner Res. 2004;19:552-559.
-
(2004)
J Bone Miner Res
, vol.19
, pp. 552-559
-
-
Ferrari, S.L.1
Karasik, D.2
Liu, J.3
-
73
-
-
20844438119
-
Association of the G-174C variant in the interleukin-6 promoter region with bone loss and fracture risk in older women
-
Moffett SP, Zmuda JM, Cauley JA, et al.; SOF Research Group. Association of the G-174C variant in the interleukin-6 promoter region with bone loss and fracture risk in older women. J Bone Miner Res. 2004;19:1612-1618.
-
(2004)
J Bone Miner Res
, vol.19
, pp. 1612-1618
-
-
Moffett, S.P.1
Zmuda, J.M.2
Cauley, J.A.3
-
74
-
-
0031732983
-
Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: Possible link between endocrinosenescence and immunosenescence
-
Straub RH, Konecna L, Hrach S, et al. Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence. J Clin Endocrinol Metab. 1998;83:2012-2017.
-
(1998)
J Clin Endocrinol Metab
, vol.83
, pp. 2012-2017
-
-
Straub, R.H.1
Konecna, L.2
Hrach, S.3
-
75
-
-
0036188807
-
Changes in proinflammatory cytokine activity after menopause
-
Pfeilschifter J, Koditz R, Pfohl M, Schatz H. Changes in proinflammatory cytokine activity after menopause. Endocr Rev. 2002;23:90-119.
-
(2002)
Endocr Rev
, vol.23
, pp. 90-119
-
-
Pfeilschifter, J.1
Koditz, R.2
Pfohl, M.3
Schatz, H.4
-
76
-
-
0033369328
-
Oestrogens prevent the increase of human serum soluble interleukin-6 receptor induced by ovariectomy in vivo and decrease its release in human osteoblastic cells in vitro
-
Girasole G, Giuliani N, Modena AB, Passeri G, Pedrazzoni M. Oestrogens prevent the increase of human serum soluble interleukin-6 receptor induced by ovariectomy in vivo and decrease its release in human osteoblastic cells in vitro. Clin Endocrinol (Oxf). 1999;51:801-807.
-
(1999)
Clin Endocrinol (Oxf)
, vol.51
, pp. 801-807
-
-
Girasole, G.1
Giuliani, N.2
Modena, A.B.3
Passeri, G.4
Pedrazzoni, M.5
-
77
-
-
0029013885
-
Estrogen loss upregulates hematopoiesis in the mouse: A mediating role of IL-6
-
Jilka RL, Passeri G, Girasole G, et al. Estrogen loss upregulates hematopoiesis in the mouse: a mediating role of IL-6. Exp Hematol. 1995;23:500-506.
-
(1995)
Exp Hematol
, vol.23
, pp. 500-506
-
-
Jilka, R.L.1
Passeri, G.2
Girasole, G.3
-
78
-
-
0028925088
-
Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis
-
Manolagas SC, Jilka RL. Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med. 1995;332:305-311.
-
(1995)
N Engl J Med
, vol.332
, pp. 305-311
-
-
Manolagas, S.C.1
Jilka, R.L.2
-
79
-
-
0036312050
-
Cytokine changes in postmenopausal women treated with estrogens: A placebo-controlled study
-
Berg G, Ekerfelt C, Hammar M, Lindgren R, Matthiesen L, Ernerudh J. Cytokine changes in postmenopausal women treated with estrogens: a placebo-controlled study. Am J Reprod Immunol. 2002;48:63-69.
-
(2002)
Am J Reprod Immunol
, vol.48
, pp. 63-69
-
-
Berg, G.1
Ekerfelt, C.2
Hammar, M.3
Lindgren, R.4
Matthiesen, L.5
Ernerudh, J.6
-
80
-
-
4444279560
-
The effect of different doses of micronized 17beta-estradiol on C-reactive protein, interleukin-6, and lipids in older women
-
Prestwood KM, Unson C, Kulldorff M, Cushman M. The effect of different doses of micronized 17beta-estradiol on C-reactive protein, interleukin-6, and lipids in older women. J Gerontol A Biol Sci Med Sci. 2004;59A:827-832.
-
(2004)
J Gerontol a Biol Sci Med Sci
, vol.59
, pp. 827-832
-
-
Prestwood, K.M.1
Unson, C.2
Kulldorff, M.3
Cushman, M.4
-
81
-
-
0242272313
-
Hormone replacement therapy in rheumatoid arthritis is associated with lower serum levels of soluble IL-6 receptor and higher insulin-like growth factor 1
-
D'Elia HF, Mattsson LA, Ohlsson C, Nordborg E, Carlsten H. Hormone replacement therapy in rheumatoid arthritis is associated with lower serum levels of soluble IL-6 receptor and higher insulin-like growth factor 1. Arthritis Res. 2003;5:R202-R209.
-
(2003)
Arthritis Res
, vol.5
-
-
D'Elia, H.F.1
Mattsson, L.A.2
Ohlsson, C.3
Nordborg, E.4
Carlsten, H.5
-
82
-
-
0032799854
-
Sex hormones modulate inflammatory mediators produced by macrophages
-
D'Agostino P, Milano S, Barbera C, et al. Sex hormones modulate inflammatory mediators produced by macrophages. Ann N Y AcadSci. 1999;876:426-429.
-
(1999)
Ann N Y AcadSci
, vol.876
, pp. 426-429
-
-
D'Agostino, P.1
Milano, S.2
Barbera, C.3
-
83
-
-
0029051331
-
Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor
-
Bellido T, Jilka RL, Boyce BF, et al. Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor. J Clin Invest. 1995;95:2886-2895.
-
(1995)
J Clin Invest
, vol.95
, pp. 2886-2895
-
-
Bellido, T.1
Jilka, R.L.2
Boyce, B.F.3
-
84
-
-
0032803730
-
The anti-androgen hydroxyflutamide and androgens inhibit interleukin-6 production by an androgen-responsive human osteoblastic cell line
-
Hofbauer LC, Ten RM, Khosla S. The anti-androgen hydroxyflutamide and androgens inhibit interleukin-6 production by an androgen-responsive human osteoblastic cell line. J Bone Miner Res. 1999;14:1330-1337.
-
(1999)
J Bone Miner Res
, vol.14
, pp. 1330-1337
-
-
Hofbauer, L.C.1
Ten, R.M.2
Khosla, S.3
-
85
-
-
30344449759
-
Correlation between testosterone and the inflammatory marker soluble interleukin-6 receptor in older men
-
Maggio M, Basaria S, Ble A, et al. Correlation between testosterone and the inflammatory marker soluble interleukin-6 receptor in older men. J Clin Endocrinol Metab. 2006;91:345-347.
-
(2006)
J Clin Endocrinol Metab
, vol.91
, pp. 345-347
-
-
Maggio, M.1
Basaria, S.2
Ble, A.3
-
86
-
-
0036280935
-
Effect of estrogen versus testosterone on circulating osteoprotegerin and other cytokine levels in normal elderly men
-
Khosla S, Atkinson EJ, Dunstan CR, O'Fallon WM. Effect of estrogen versus testosterone on circulating osteoprotegerin and other cytokine levels in normal elderly men. J Clin Endocrinol Metab. 2002;87:1550-1554.
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 1550-1554
-
-
Khosla, S.1
Atkinson, E.J.2
Dunstan, C.R.3
O'Fallon, W.M.4
-
87
-
-
33745200242
-
The effects of short term (3 weeks) testosterone treatment on serum inflammatory markers in men undergoing coronary artery stenting
-
Epub ahead of print
-
Guler N, Batyraliev T, Dulger H, et al. The effects of short term (3 weeks) testosterone treatment on serum inflammatory markers in men undergoing coronary artery stenting. Int J Cardiol. 2005; [Epub ahead of print].
-
(2005)
Int J Cardiol
-
-
Guler, N.1
Batyraliev, T.2
Dulger, H.3
-
88
-
-
0037320101
-
Effects of testosterone replacement and/or resistance training on interleukin-6, tumor necrosis factor alpha, and leptin in elderly men ingesting megestrol acetate: A randomized controlled trial
-
Lambert CP, Sullivan DH, Evans WJ. Effects of testosterone replacement and/or resistance training on interleukin-6, tumor necrosis factor alpha, and leptin in elderly men ingesting megestrol acetate: a randomized controlled trial. J Gerontol A Biol Sci Med Sci. 2003;58A:165-170.
-
(2003)
J Gerontol A Biol Sci Med Sci
, vol.58 A
, pp. 165-170
-
-
Lambert, C.P.1
Sullivan, D.H.2
Evans, W.J.3
-
89
-
-
3242667701
-
The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men
-
Malkin CJ, Pugh PJ, Jones RD, Kapoor D, Channer KS, Jones TH. The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men. J Clin Endocrinol Metab. 2004;89:3313-3318.
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 3313-3318
-
-
Malkin, C.J.1
Pugh, P.J.2
Jones, R.D.3
Kapoor, D.4
Channer, K.S.5
Jones, T.H.6
-
90
-
-
0029662224
-
Inhibition of NFkappaB activity through maintenance of I kappa B alpha levels contributes to dihydrotestosterone-mediated repression of the interleukin-6 promoter
-
Keller ET, Chang C, Ershler WB. Inhibition of NFkappaB activity through maintenance of I kappa B alpha levels contributes to dihydrotestosterone- mediated repression of the interleukin-6 promoter. J Biol Chem. 1996;271:26267-26275.
-
(1996)
J Biol Chem
, vol.271
, pp. 26267-26275
-
-
Keller, E.T.1
Chang, C.2
Ershler, W.B.3
-
91
-
-
3242676731
-
Dehydroepiandrosterone-sulfate inhibits nuclear factor-kappaB-dependent transcription in hepatocytes, possibly through antioxidant effect
-
Iwasaki Y, Asai M, Yoshida M, Nigawara T, Kambayashi M, Nakashima N. Dehydroepiandrosterone-sulfate inhibits nuclear factor-kappaB-dependent transcription in hepatocytes, possibly through antioxidant effect. J Clin Endocrinol Metab. 2004;89:3449-3454.
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 3449-3454
-
-
Iwasaki, Y.1
Asai, M.2
Yoshida, M.3
Nigawara, T.4
Kambayashi, M.5
Nakashima, N.6
-
93
-
-
2642541669
-
Serum levels of insulin-like growth factor-1 (IGF-I) and dehydroepiandrosterone sulfate (DHEA-S), and their relationships with serum interleukin-6, in the geriatric syndrome of frailty
-
Leng SX, Cappola AR, Andersen RE, et al. Serum levels of insulin-like growth factor-1 (IGF-I) and dehydroepiandrosterone sulfate (DHEA-S), and their relationships with serum interleukin-6, in the geriatric syndrome of frailty. Aging Clin Exp Res. 2004;16:153-157.
-
(2004)
Aging Clin Exp Res
, vol.16
, pp. 153-157
-
-
Leng, S.X.1
Cappola, A.R.2
Andersen, R.E.3
-
94
-
-
0034473259
-
Cross-sectional and prospective relationships of interleukin-6 and C-reactive protein with physical performance in elderly persons: MacArthur studies of successful aging
-
Taaffe DR, Harris TB, Ferrucci L, Rowe J, Seeman TE. Cross-sectional and prospective relationships of interleukin-6 and C-reactive protein with physical performance in elderly persons: MacArthur studies of successful aging. J Gerontol A Biol Sci Med Sci. 2000;55A:M709-M715.
-
(2000)
J Gerontol A Biol Sci Med Sci
, vol.55 A
-
-
Taaffe, D.R.1
Harris, T.B.2
Ferrucci, L.3
Rowe, J.4
Seeman, T.E.5
-
95
-
-
1642316427
-
Inflammatory markers and physical performance in older persons: The InCHIANTI study
-
Cesari M, Penninx BW, Pahor M, et al. Inflammatory markers and physical performance in older persons: the InCHIANTI study. J Gerontol A Biol Sci Med Sci. 2004;59A:242-248.
-
(2004)
J Gerontol A Biol Sci Med Sci
, vol.59 A
, pp. 242-248
-
-
Cesari, M.1
Penninx, B.W.2
Pahor, M.3
-
96
-
-
0036068710
-
Serum interleukin-6 and hemoglobin as physiological correlates in the geriatric syndrome of frailty: A pilot study
-
Leng S, Chaves P, Koenig K, Walston J. Serum interleukin-6 and hemoglobin as physiological correlates in the geriatric syndrome of frailty: a pilot study. J Am Geriatr Soc. 2002;50:1268-1271.
-
(2002)
J Am Geriatr Soc
, vol.50
, pp. 1268-1271
-
-
Leng, S.1
Chaves, P.2
Koenig, K.3
Walston, J.4
-
97
-
-
0033024330
-
Serum IL-6 level and the development of disability in older persons
-
Ferrucci L, Harris TB, Guralnik JM, et al. Serum IL-6 level and the development of disability in older persons. J Am Geriatr Soc. 1999;47:639-646.
-
(1999)
J Am Geriatr Soc
, vol.47
, pp. 639-646
-
-
Ferrucci, L.1
Harris, T.B.2
Guralnik, J.M.3
-
98
-
-
0034853487
-
Association of IGF-I levels with muscle strength and mobility in older women
-
Cappola AR, Bandeen-Roche K, Wand GS, Volpato S, Fried LP. Association of IGF-I levels with muscle strength and mobility in older women. J Clin Endocrinol Metab. 2001;86:4139-4146.
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 4139-4146
-
-
Cappola, A.R.1
Bandeen-Roche, K.2
Wand, G.S.3
Volpato, S.4
Fried, L.P.5
-
99
-
-
0037372505
-
Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons
-
Barbieri M, Ferrucci L, Ragno E, et al. Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons. Am J Physiol Endocrinol Metab. 2003;284:E481-E487.
-
(2003)
Am J Physiol Endocrinol Metab
, vol.284
-
-
Barbieri, M.1
Ferrucci, L.2
Ragno, E.3
-
100
-
-
0038369150
-
Insulin-like growth factor 1 and interleukin-6 contribute synergistically to disability and mortality in older women
-
Cappola AR, Xue QL, Ferrucci L, Guralnik JM, Volpato S, Fried LP. Insulin-like growth factor 1 and interleukin-6 contribute synergistically to disability and mortality in older women. J Clin Endocrinol Metab. 2003;88:2019-2025.
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 2019-2025
-
-
Cappola, A.R.1
Xue, Q.L.2
Ferrucci, L.3
Guralnik, J.M.4
Volpato, S.5
Fried, L.P.6
-
102
-
-
33745209287
-
Inflammation: The fire of frailty?
-
Carey JR, Robine J-M, Michel JP, Christen Y (eds.) New York: Springer
-
Ferrucci L, Ble A, Bandinelli S, Windham BG, Simonsick EM. Inflammation: the fire of frailty? In: Carey JR, Robine J-M, Michel JP, Christen Y (eds.) Longevity und Frailty. Research and Perspectives in Longevity, Vol. XII. New York: Springer; 2005:91-98.
-
(2005)
Longevity und Frailty. Research and Perspectives in Longevity
, vol.12
, pp. 91-98
-
-
Ferrucci, L.1
Ble, A.2
Bandinelli, S.3
Windham, B.G.4
Simonsick, E.M.5
-
103
-
-
23644462708
-
Interleukin-6 and new strategies for the treatment of cancer, hyperproliferative diseases and paraneoplastic syndromes
-
Burton BE. Interleukin-6 and new strategies for the treatment of cancer, hyperproliferative diseases and paraneoplastic syndromes. Expert Opin Ther Targets. 2005;9:737-752.
-
(2005)
Expert Opin Ther Targets
, vol.9
, pp. 737-752
-
-
Burton, B.E.1
-
104
-
-
0033001902
-
Cell cycle regulation and induction of apoptosis by IL-6 variants on the multiple myeloma cell line XG-1
-
Petrucci MT, Ricciardi MR, Ariola C, et al. Cell cycle regulation and induction of apoptosis by IL-6 variants on the multiple myeloma cell line XG-1. Ann Hematol. 1999;78:13-18.
-
(1999)
Ann Hematol
, vol.78
, pp. 13-18
-
-
Petrucci, M.T.1
Ricciardi, M.R.2
Ariola, C.3
-
105
-
-
9144231336
-
Interleukin-6-dependent gene expression profiles in multiple myeloma INA-6 cells reveal a Bcl-2 family-independent survival pathway closely associated with Stat3 activation
-
Brocke-Heidrich K, Kretzschmar AK, Pfeifer G, et al. Interleukin-6- dependent gene expression profiles in multiple myeloma INA-6 cells reveal a Bcl-2 family-independent survival pathway closely associated with Stat3 activation. Blood. 2004;103:242-251.
-
(2004)
Blood
, vol.103
, pp. 242-251
-
-
Brocke-Heidrich, K.1
Kretzschmar, A.K.2
Pfeifer, G.3
-
106
-
-
0035667565
-
Plasma levels of interleukin-6 and its soluble receptor are associated with prostate cancer progression and metastasis
-
Shariat SF, Andrews B, Kattan MW, Kim J, Wheeler TM, Slawin KM. Plasma levels of interleukin-6 and its soluble receptor are associated with prostate cancer progression and metastasis. Urology. 2001;58:1008-1015.
-
(2001)
Urology
, vol.58
, pp. 1008-1015
-
-
Shariat, S.F.1
Andrews, B.2
Kattan, M.W.3
Kim, J.4
Wheeler, T.M.5
Slawin, K.M.6
-
107
-
-
0142250392
-
Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: A review of the rationale and clinical evidence
-
Trikha M, Corringham R, Klein B, Rossi JF. Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: a review of the rationale and clinical evidence. Clin Cancer Res. 2003;9:4653-4665.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 4653-4665
-
-
Trikha, M.1
Corringham, R.2
Klein, B.3
Rossi, J.F.4
-
108
-
-
17644368573
-
Interleukin-6: From basic science to medicine-40 years in immunology
-
Kishimoto T. Interleukin-6: from basic science to medicine-40 years in immunology. Annu Rev Immunol. 2005;23:1-21.
-
(2005)
Annu Rev Immunol
, vol.23
, pp. 1-21
-
-
Kishimoto, T.1
-
109
-
-
0029166033
-
Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease
-
Soulier J, Grollet L, Oksenhendler E, et al. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood. 1995;86:1276-1280.
-
(1995)
Blood
, vol.86
, pp. 1276-1280
-
-
Soulier, J.1
Grollet, L.2
Oksenhendler, E.3
-
110
-
-
0037015683
-
IL-6 mediated activation of STAT3 bypasses Janus kinases in terminally differentiated B lineage cells
-
Kopantzev Y, Heller M, Swaminathan N, Rudikoff S. IL-6 mediated activation of STAT3 bypasses Janus kinases in terminally differentiated B lineage cells. Oncogene. 2002;21:6791-6800.
-
(2002)
Oncogene
, vol.21
, pp. 6791-6800
-
-
Kopantzev, Y.1
Heller, M.2
Swaminathan, N.3
Rudikoff, S.4
-
111
-
-
0030057701
-
Soluble interleukin-6 receptor as a prognostic factor in multiple myeloma
-
Finnish Leukaemia Group
-
Pulkki K, Pelliniemi TT, Rajamaki A, Tienhaara A, Laakso M, Lahtinen R. Soluble interleukin-6 receptor as a prognostic factor in multiple myeloma. Finnish Leukaemia Group. Br J Haematol. 1996;92:370-374.
-
(1996)
Br J Haematol
, vol.92
, pp. 370-374
-
-
Pulkki, K.1
Pelliniemi, T.T.2
Rajamaki, A.3
Tienhaara, A.4
Laakso, M.5
Lahtinen, R.6
-
112
-
-
0029914360
-
Soluble interleukin-6 receptor (sIL-6R), a new prognostic factor in multiple myeloma
-
Kyrtsonis MC, Dedoussis G, Zervas C, et al. Soluble interleukin-6 receptor (sIL-6R), a new prognostic factor in multiple myeloma. Br J Haematol. 1996;93:398-400.
-
(1996)
Br J Haematol
, vol.93
, pp. 398-400
-
-
Kyrtsonis, M.C.1
Dedoussis, G.2
Zervas, C.3
-
113
-
-
0031257715
-
Serum soluble IL-6 receptor concentrations correlate with stages of multiple myeloma defined by serum beta 2-microglobulin and C-reactive protein
-
Kyriakou D, Papadaki H, Eliopoulos AG, Foudoulakis A, Alexandrakis M, Eliopoulos GD. Serum soluble IL-6 receptor concentrations correlate with stages of multiple myeloma defined by serum beta 2-microglobulin and C-reactive protein. Int J Hematol. 1997;66:367-371.
-
(1997)
Int J Hematol
, vol.66
, pp. 367-371
-
-
Kyriakou, D.1
Papadaki, H.2
Eliopoulos, A.G.3
Foudoulakis, A.4
Alexandrakis, M.5
Eliopoulos, G.D.6
-
115
-
-
0031710647
-
Ciliary neurotrophic factor potentiates the beta-cell inhibitory effect of IL-1beta in rat pancreatic islets associated with increased nitric oxide synthesis and increased expression of inducible nitric oxide synthase
-
Wadt KA, Larsen CM, Andersen HU, Nielsen K, Karlsen AE, Mandrup-Poulsen T. Ciliary neurotrophic factor potentiates the beta-cell inhibitory effect of IL-1beta in rat pancreatic islets associated with increased nitric oxide synthesis and increased expression of inducible nitric oxide synthase. Diabetes. 1998;47:1602-1608.
-
(1998)
Diabetes
, vol.47
, pp. 1602-1608
-
-
Wadt, K.A.1
Larsen, C.M.2
Andersen, H.U.3
Nielsen, K.4
Karlsen, A.E.5
Mandrup-Poulsen, T.6
-
116
-
-
0042839568
-
Role of cytokines in the pathogenesis of autoimmune diabetes mellitus
-
Rabinovitch A, Suarez-Pinzon WL. Role of cytokines in the pathogenesis of autoimmune diabetes mellitus. Rev Endocr Metab Disord. 2003;4:291-299.
-
(2003)
Rev Endocr Metab Disord
, vol.4
, pp. 291-299
-
-
Rabinovitch, A.1
Suarez-Pinzon, W.L.2
-
117
-
-
2942564469
-
IL-6 protects pancreatic islet beta cells from pro-inflammatory cytokines-induced cell death and functional impairment in vitro and in vivo
-
Choi SE, Choi KM, Yoon IH, et al. IL-6 protects pancreatic islet beta cells from pro-inflammatory cytokines-induced cell death and functional impairment in vitro and in vivo. Transpl Immunol. 2004;13:43-53.
-
(2004)
Transpl Immunol
, vol.13
, pp. 43-53
-
-
Choi, S.E.1
Choi, K.M.2
Yoon, I.H.3
-
118
-
-
0028971717
-
Demonstration of a TH1 cytokine profile in the late phase of NOD insulitis
-
Pilstrom B, Bjork L, Bohme J. Demonstration of a TH1 cytokine profile in the late phase of NOD insulitis. Cytokine. 1995;7:806-814.
-
(1995)
Cytokine
, vol.7
, pp. 806-814
-
-
Pilstrom, B.1
Bjork, L.2
Bohme, J.3
-
119
-
-
33644755633
-
Interleukin-6 and diabetes: The good, the bad, or the indifferent?
-
Kristiansen OP, Mandrup-Poulsen T. Interleukin-6 and diabetes: the good, the bad, or the indifferent? Diabetes. 2005;54(Suppl 2):S114-S124.
-
(2005)
Diabetes
, vol.54
, Issue.SUPPL. 2
-
-
Kristiansen, O.P.1
Mandrup-Poulsen, T.2
-
120
-
-
1442301080
-
Inflammatory markers and risk of developing type 2 diabetes in women
-
Hu FB, Meigs JB, Li TY, Rifai N, Manson JE. Inflammatory markers and risk of developing type 2 diabetes in women. Diabetes. 2004;53:693-700.
-
(2004)
Diabetes
, vol.53
, pp. 693-700
-
-
Hu, F.B.1
Meigs, J.B.2
Li, T.Y.3
Rifai, N.4
Manson, J.E.5
-
121
-
-
0345700727
-
Inflammatory cytokines and the risk to develop type 2 diabetes: Results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
-
Spranger J, Kroke A, Mohlig M, et al. Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Diabetes. 2003;52:812-817.
-
(2003)
Diabetes
, vol.52
, pp. 812-817
-
-
Spranger, J.1
Kroke, A.2
Mohlig, M.3
-
122
-
-
0035908632
-
C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus
-
Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA. 2001;286:327-334.
-
(2001)
JAMA
, vol.286
, pp. 327-334
-
-
Pradhan, A.D.1
Manson, J.E.2
Rifai, N.3
Buring, J.E.4
Ridker, P.M.5
-
124
-
-
2342510407
-
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepeidin
-
Nemeth E, Rivera S, Gabayan V, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepeidin. J Clin Invest. 2004;113:1271-1276.
-
(2004)
J Clin Invest
, vol.113
, pp. 1271-1276
-
-
Nemeth, E.1
Rivera, S.2
Gabayan, V.3
-
125
-
-
0033162263
-
Advances in the anemia of chronic disease
-
Means RT, Jr. Advances in the anemia of chronic disease. Int J Hematol. 1999;70:7-12.
-
(1999)
Int J Hematol
, vol.70
, pp. 7-12
-
-
Means Jr., R.T.1
-
126
-
-
0023223250
-
Inhibition by interleukin-1 of the action of erythropoietin on erythroid precursors and its possible role in the pathogenesis of hypoplastic anaemias
-
Schooley JC, Kullgren B, Allison AC. Inhibition by interleukin-1 of the action of erythropoietin on erythroid precursors and its possible role in the pathogenesis of hypoplastic anaemias. Br J Haematol. 1987;67:11-17.
-
(1987)
Br J Haematol
, vol.67
, pp. 11-17
-
-
Schooley, J.C.1
Kullgren, B.2
Allison, A.C.3
-
127
-
-
0016379537
-
Bone marrow erythropoiesis in the anemia of infection, inflammation, and malignancy
-
Zucker S, Friedmnn S, Lysik RM. Bone marrow erythropoiesis in the anemia of infection, inflammation, and malignancy. J Clin Invest. 1974;53:1132-1138.
-
(1974)
J Clin Invest
, vol.53
, pp. 1132-1138
-
-
Zucker, S.1
Friedmnn, S.2
Lysik, R.M.3
-
128
-
-
0028796711
-
Soluble interleukin-6 receptors in inflammatory bowel disease: Relation to circulating interleukin-6
-
Milsuyama K, Toyonaga A, Sasaki E, et al. Soluble interleukin-6 receptors in inflammatory bowel disease: relation to circulating interleukin-6. Gut. 1995;36:45-49.
-
(1995)
Gut
, vol.36
, pp. 45-49
-
-
Milsuyama, K.1
Toyonaga, A.2
Sasaki, E.3
-
129
-
-
0026607022
-
Evidence for continuous stimulation of interleukin-6 production in Crohn's disease
-
Gross V, Andus T, Caesar I, Roth M, Scholmerich J. Evidence for continuous stimulation of interleukin-6 production in Crohn's disease. Gastroenterology. 1992;102:514-519.
-
(1992)
Gastroenterology
, vol.102
, pp. 514-519
-
-
Gross, V.1
Andus, T.2
Caesar, I.3
Roth, M.4
Scholmerich, J.5
-
130
-
-
0033179725
-
Clinical relevance of serum interleukin-6 in Crohn's disease: Single point measurements, therapy monitoring, and prediction of clinical relapse
-
Reinisch W, Gasche C, Tillinger W, et al. Clinical relevance of serum interleukin-6 in Crohn's disease: single point measurements, therapy monitoring, and prediction of clinical relapse. Am J Gastroenterol. 1999;94:2156-2164.
-
(1999)
Am J Gastroenterol
, vol.94
, pp. 2156-2164
-
-
Reinisch, W.1
Gasche, C.2
Tillinger, W.3
-
131
-
-
0035910753
-
C1S3/SOCS3/SS13 plays a negative regulatory role in STAT3 activation and intestinal inflammation
-
Suzuki A, Hanada T, Mitsuyama K, et al. C1S3/SOCS3/SS13 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J Exp Med. 2001;193:471-481.
-
(2001)
J Exp Med
, vol.193
, pp. 471-481
-
-
Suzuki, A.1
Hanada, T.2
Mitsuyama, K.3
-
132
-
-
0032254376
-
Increased interleukin-6 levels, interleukin-6 receptor and gp130 expression in peripheral lymphocytes of patients with inflammatory bowel disease
-
Holub MC, Mako E, Devay T, et al. Increased interleukin-6 levels, interleukin-6 receptor and gp130 expression in peripheral lymphocytes of patients with inflammatory bowel disease. Scand J Gastroenterol Suppl. 1998;228:47-50.
-
(1998)
Scand J Gastroenterol Suppl
, vol.228
, pp. 47-50
-
-
Holub, M.C.1
Mako, E.2
Devay, T.3
-
133
-
-
4344590199
-
Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice
-
Hata H, Sakaguchi N, Yoshitomi H, et al. Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice. J Clin Invest. 2004;114:582-588.
-
(2004)
J Clin Invest
, vol.114
, pp. 582-588
-
-
Hata, H.1
Sakaguchi, N.2
Yoshitomi, H.3
-
134
-
-
0023942493
-
Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides
-
Houssiau FA, Devogelaer JP, Van Damme J, de Deuxchaisnes CN, VanSnick J. Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides. Arthritis Rheum. 1988;31:784-788.
-
(1988)
Arthritis Rheum
, vol.31
, pp. 784-788
-
-
Houssiau, F.A.1
Devogelaer, J.P.2
Van Damme, J.3
De Deuxchaisnes, C.N.4
Vansnick, J.5
-
135
-
-
13344250490
-
Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation
-
Kotake S, Sato K, Kim KJ, et al. Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation. J Bone Miner Res. 1996;11:88-95.
-
(1996)
J Bone Miner Res
, vol.11
, pp. 88-95
-
-
Kotake, S.1
Sato, K.2
Kim, K.J.3
-
136
-
-
0027518860
-
Serum interleukin 6 levels in rheumatoid arthritis: Correlations with clinical and laboratory indices of disease activity
-
Madhok R, Crilly A, Watson J, Capell HA. Serum interleukin 6 levels in rheumatoid arthritis: correlations with clinical and laboratory indices of disease activity. Ann Rheum Dis. 1993;52:232-234.
-
(1993)
Ann Rheum Dis
, vol.52
, pp. 232-234
-
-
Madhok, R.1
Crilly, A.2
Watson, J.3
Capell, H.A.4
-
138
-
-
0344333426
-
Interleukin-6 (IL-6) and soluble forms of IL-6 receptors are not altered in cerebrospinal fluid of Alzheimer's disease patients
-
Marz P, Heese K, Hock C, et al. Interleukin-6 (IL-6) and soluble forms of IL-6 receptors are not altered in cerebrospinal fluid of Alzheimer's disease patients. Neurosci Lett. 1997;239:29-32.
-
(1997)
Neurosci Lett
, vol.239
, pp. 29-32
-
-
Marz, P.1
Heese, K.2
Hock, C.3
-
139
-
-
18244413523
-
Decreased soluble interleukin-6 receptor in cerebrospinal fluid of patients with Alzheimer's disease
-
Hampel H, Sunderland T, Kotter HU, et al. Decreased soluble interleukin-6 receptor in cerebrospinal fluid of patients with Alzheimer's disease. Brain Res. 1998;780:356-359.
-
(1998)
Brain Res
, vol.780
, pp. 356-359
-
-
Hampel, H.1
Sunderland, T.2
Kotter, H.U.3
-
140
-
-
0028148227
-
A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B
-
Traenckner EB, Wilk S, Baeuerle PA. A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B. Embo J. 1994;13:5433-5441.
-
(1994)
Embo J
, vol.13
, pp. 5433-5441
-
-
Traenckner, E.B.1
Wilk, S.2
Baeuerle, P.A.3
-
141
-
-
13044316560
-
Role of the proteasome and NF-kappa B in streptococcal cell wall-induced polyarthritis
-
Palombella VJ, Conner EM, Fuseler JW, et al. Role of the proteasome and NF-kappa B in streptococcal cell wall-induced polyarthritis. Proc Natl Acad Sci U S A. 1998;95:15671-15676.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 15671-15676
-
-
Palombella, V.J.1
Conner, E.M.2
Fuseler, J.W.3
-
142
-
-
33144469102
-
The proteasome and proteasome inhibitors in cancer therapy
-
Voorhees PM, Orlowski RZ. The proteasome and proteasome inhibitors in cancer therapy. Annu Rev Pharmacol Toxicol. 2006;46:189-213.
-
(2006)
Annu Rev Pharmacol Toxicol
, vol.46
, pp. 189-213
-
-
Voorhees, P.M.1
Orlowski, R.Z.2
-
143
-
-
26844453345
-
Perspectives for combination therapy to overcome drug-resistant multiple myeloma
-
Catley L, Tai YT, Chauhan D, Anderson KC. Perspectives for combination therapy to overcome drug-resistant multiple myeloma. Drug Resist Updat. 2005;8:205-218.
-
(2005)
Drug Resist Updat
, vol.8
, pp. 205-218
-
-
Catley, L.1
Tai, Y.T.2
Chauhan, D.3
Anderson, K.C.4
-
144
-
-
9344259121
-
Human interleukin-6 receptor super-antagonists with high potency and wide spectrum on multiple myeloma cells
-
Sporeno E, Savino R, Ciapponi L, et al. Human interleukin-6 receptor super-antagonists with high potency and wide spectrum on multiple myeloma cells. Blood. 1996;87:4510-4519.
-
(1996)
Blood
, vol.87
, pp. 4510-4519
-
-
Sporeno, E.1
Savino, R.2
Ciapponi, L.3
-
145
-
-
0033001902
-
Cell cycle regulation and induction of apoptosis by IL-6 variants on the multiple myeloma cell line XG-1
-
Petrucci MT, Ricciardi MR, Ariola C, et al. Cell cycle regulation and induction of apoptosis by IL-6 variants on the multiple myeloma cell line XG-1. Ann Hematol. 1999;78:13-18.
-
(1999)
Ann Hematol
, vol.78
, pp. 13-18
-
-
Petrucci, M.T.1
Ricciardi, M.R.2
Ariola, C.3
-
146
-
-
19644389279
-
Interleukin 6 supports the maintenance of p53 tumor suppressor gene promoter methylation
-
Hodge DR, Peng B, Cherry JC, et al. Interleukin 6 supports the maintenance of p53 tumor suppressor gene promoter methylation. Cancer Res. 2005;65:4673-4682.
-
(2005)
Cancer Res
, vol.65
, pp. 4673-4682
-
-
Hodge, D.R.1
Peng, B.2
Cherry, J.C.3
-
147
-
-
0028223116
-
Humanization of a mouse anti-human interleukin-6 receptor antibody comparing two methods for selecting human framework regions
-
Sato K, Tsuchiya M, Saldanha J, et al. Humanization of a mouse anti-human interleukin-6 receptor antibody comparing two methods for selecting human framework regions. Mol Immunol. 1994;31:371-381.
-
(1994)
Mol Immunol
, vol.31
, pp. 371-381
-
-
Sato, K.1
Tsuchiya, M.2
Saldanha, J.3
-
148
-
-
20344381320
-
The therapy of autoimmune diseases by anti-interleukin-6 receptor antibody
-
Mihara M, Nishimoto N, Ohsugi Y. The therapy of autoimmune diseases by anti-interleukin-6 receptor antibody. Expert Opin Biol Ther. 2005;5:683-690.
-
(2005)
Expert Opin Biol Ther
, vol.5
, pp. 683-690
-
-
Mihara, M.1
Nishimoto, N.2
Ohsugi, Y.3
-
149
-
-
2642558925
-
Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: A multicenter, double-blind, placebo-controlled trial
-
Nishimoto N, Yoshizaki K, Miyasaka N, et al. Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial. Arthritis Rheum. 2004;50:1761-1769.
-
(2004)
Arthritis Rheum
, vol.50
, pp. 1761-1769
-
-
Nishimoto, N.1
Yoshizaki, K.2
Miyasaka, N.3
-
150
-
-
2942752122
-
Rationale for interleukin-6 blockade in systemic lupus erythematosus
-
Tackey E, Lipsky PE, Illei GG. Rationale for interleukin-6 blockade in systemic lupus erythematosus. Lupus. 2004;13:339-343.
-
(2004)
Lupus
, vol.13
, pp. 339-343
-
-
Tackey, E.1
Lipsky, P.E.2
Illei, G.G.3
-
151
-
-
0033959608
-
Improvement in Castleman's disease by humanized anti-interleukin-6 receptor antibody therapy
-
Nishimoto N, Sasai M, Shima Y, et al. Improvement in Castleman's disease by humanized anti-interleukin-6 receptor antibody therapy. Blood. 2000;95:56-61.
-
(2000)
Blood
, vol.95
, pp. 56-61
-
-
Nishimoto, N.1
Sasai, M.2
Shima, Y.3
-
152
-
-
27144488346
-
Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease
-
Nishimoto N, Kanakura Y, Aozasa K, et al. Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease. Blood. 2005;106:2627-2632.
-
(2005)
Blood
, vol.106
, pp. 2627-2632
-
-
Nishimoto, N.1
Kanakura, Y.2
Aozasa, K.3
-
153
-
-
0042834261
-
Soluble IL-6 receptor governs 1L-6 activity in experimental arthritis: Blockade of arthritis severity by soluble glycoprotein 130
-
Nowell MA, Richards PJ, Horiuchi S, et al. Soluble IL-6 receptor governs 1L-6 activity in experimental arthritis: blockade of arthritis severity by soluble glycoprotein 130. J Immunol. 2003;171:3202-3209.
-
(2003)
J Immunol
, vol.171
, pp. 3202-3209
-
-
Nowell, M.A.1
Richards, P.J.2
Horiuchi, S.3
-
154
-
-
33644818803
-
A form of circulating interleukin-6 receptor component soluble gp!30 as a potential interleukin-6 inhibitor in inflammatory bowel disease
-
Mitsuyama K, Tomiyasu N, Suzuki A, et al. A form of circulating interleukin-6 receptor component soluble gp!30 as a potential interleukin-6 inhibitor in inflammatory bowel disease. Clin Exp Immunol. 2006;143:125-131.
-
(2006)
Clin Exp Immunol
, vol.143
, pp. 125-131
-
-
Mitsuyama, K.1
Tomiyasu, N.2
Suzuki, A.3
-
155
-
-
0001123864
-
JAK3, STAT, and MAPK signalling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response
-
Wang LH, Kirken RA, Erwin RA, Yu CR, Farrar WL. JAK3, STAT, and MAPK signalling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response. J Immunol. 1999;162:3897-3904.
-
(1999)
J Immunol
, vol.162
, pp. 3897-3904
-
-
Wang, L.H.1
Kirken, R.A.2
Erwin, R.A.3
Yu, C.R.4
Farrar, W.L.5
-
156
-
-
0037444373
-
Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice
-
Blaskovich MA, Sun J, Cantor A, Turkson J, Jove R, Sebti SM. Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res. 2003;63:1270-1279.
-
(2003)
Cancer Res
, vol.63
, pp. 1270-1279
-
-
Blaskovich, M.A.1
Sun, J.2
Cantor, A.3
Turkson, J.4
Jove, R.5
Sebti, S.M.6
-
157
-
-
0036738122
-
Farnesyl transferase inhibitor R115777 induces apoptosis of human myeloma cells
-
Le Gouill S, Pellat-Deceunynck C, Harousseau JL, et al. Farnesyl transferase inhibitor R115777 induces apoptosis of human myeloma cells. Leukemia. 2002;16:1664-1667.
-
(2002)
Leukemia
, vol.16
, pp. 1664-1667
-
-
Le Gouill, S.1
Pellat-Deceunynck, C.2
Harousseau, J.L.3
-
158
-
-
28844500739
-
The combination of the farnesyl transferase inhibitor lonafarnib and the proteasome inhibitor bortezomib induces synergistic apoptosis in human myeloma cells that is associated with down-regulation of p-AKT
-
David E, Sun SY, Waller EK, Chen J, Khuri FR, Lonial S. The combination of the farnesyl transferase inhibitor lonafarnib and the proteasome inhibitor bortezomib induces synergistic apoptosis in human myeloma cells that is associated with down-regulation of p-AKT. Blood. 2005;106:4322-329.
-
(2005)
Blood
, vol.106
, pp. 4322-4329
-
-
David, E.1
Sun, S.Y.2
Waller, E.K.3
Chen, J.4
Khuri, F.R.5
Lonial, S.6
-
159
-
-
20144379879
-
Statins reduce interleukin-6-induced C-reactive protein in human hepatocytes: New evidence for direct antiinflammatory effects of statins
-
Arnaud C, Burger F, Steffens S, et al. Statins reduce interleukin-6-induced C-reactive protein in human hepatocytes: new evidence for direct antiinflammatory effects of statins. Arterioscler Thromb Vasc Biol. 2005;25:1231-1236.
-
(2005)
Arterioscler Thromb Vasc Biol
, vol.25
, pp. 1231-1236
-
-
Arnaud, C.1
Burger, F.2
Steffens, S.3
-
160
-
-
0141955061
-
Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells
-
Bharti AC, Donato N, Aggarwal BB. Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells. J Immunol. 2003;171:3863-3871.
-
(2003)
J Immunol
, vol.171
, pp. 3863-3871
-
-
Bharti, A.C.1
Donato, N.2
Aggarwal, B.B.3
-
161
-
-
18844370367
-
Cucurbitacin Q: A selective STAT3 activation inhibitor with potent antitumor activity
-
Sun J, Blaskovich MA, Jove R, Livingston SK, Coppola D, Sebti SM. Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity. Oncogene. 2005;24:3236-3245,
-
(2005)
Oncogene
, vol.24
, pp. 3236-3245
-
-
Sun, J.1
Blaskovich, M.A.2
Jove, R.3
Livingston, S.K.4
Coppola, D.5
Sebti, S.M.6
-
162
-
-
8444253302
-
Stabilization, not polymerization, of microtubules inhibits the nuclear translocation of STATs in adipocytes
-
Gleason EL, Hogan JC, Stephens JM. Stabilization, not polymerization, of microtubules inhibits the nuclear translocation of STATs in adipocytes. Biochem Biophys Res Commun. 2004;325:716-718.
-
(2004)
Biochem Biophys Res Commun
, vol.325
, pp. 716-718
-
-
Gleason, E.L.1
Hogan, J.C.2
Stephens, J.M.3
-
163
-
-
3543070089
-
The interaction of specific peptide aptamers with the DNA binding domain and the dimerization domain of the transcription factor Stat3 inhibits transactivation and induces apoptosis in tumor cells
-
Nagel-Wolfrum K, Buerger C, Wittig I, Butz K, Hoppe-Seyler F, Groner B. The interaction of specific peptide aptamers with the DNA binding domain and the dimerization domain of the transcription factor Stat3 inhibits transactivation and induces apoptosis in tumor cells. Mol Cancer Res. 2004;2:170-182.
-
(2004)
Mol Cancer Res
, vol.2
, pp. 170-182
-
-
Nagel-Wolfrum, K.1
Buerger, C.2
Wittig, I.3
Butz, K.4
Hoppe-Seyler, F.5
Groner, B.6
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