-
1
-
-
0033987305
-
Age-related change of plasma extracellular-superoxide dismutase
-
Adachi T., Wang J., and Wang X.L. Age-related change of plasma extracellular-superoxide dismutase. Clin. Chim. Acta 290 (2000) 169-178
-
(2000)
Clin. Chim. Acta
, vol.290
, pp. 169-178
-
-
Adachi, T.1
Wang, J.2
Wang, X.L.3
-
2
-
-
33646091308
-
Effects of aging and atherosclerosis on endothelial and vascular smooth muscle function in humans
-
Al-Shaer M.H., Choueiri N.E., Correia M.L., Sinkey C.A., Barenz T.A., and Haynes W.G. Effects of aging and atherosclerosis on endothelial and vascular smooth muscle function in humans. Int. J. Cardiol. 109 (2006) 201-206
-
(2006)
Int. J. Cardiol.
, vol.109
, pp. 201-206
-
-
Al-Shaer, M.H.1
Choueiri, N.E.2
Correia, M.L.3
Sinkey, C.A.4
Barenz, T.A.5
Haynes, W.G.6
-
3
-
-
34248662090
-
Fenofibrate improves age-related endothelial dysfunction in rat resistance arteries
-
Alvarez de Sotomayor M., Mingorance C., and Andriantsitohaina R. Fenofibrate improves age-related endothelial dysfunction in rat resistance arteries. Atherosclerosis 193 (2007) 112-120
-
(2007)
Atherosclerosis
, vol.193
, pp. 112-120
-
-
Alvarez de Sotomayor, M.1
Mingorance, C.2
Andriantsitohaina, R.3
-
4
-
-
0006905898
-
Effect of ageing on the endothelium-dependent vasorelaxation induced by acetylcholine in rat mesenteric arteries
-
Vanhoutte P.M. (Ed), Harwood Academic Publishers, Amsterdam
-
Alvarez de Sotomayor M., Stoclet J.C., and Andriantsiohaina R. Effect of ageing on the endothelium-dependent vasorelaxation induced by acetylcholine in rat mesenteric arteries. In: Vanhoutte P.M. (Ed). Endothelium-derived Hyperpolarizations (1999), Harwood Academic Publishers, Amsterdam 323-332
-
(1999)
Endothelium-derived Hyperpolarizations
, pp. 323-332
-
-
Alvarez de Sotomayor, M.1
Stoclet, J.C.2
Andriantsiohaina, R.3
-
5
-
-
33645734924
-
Age-associated impairment in vasorelaxation to fluid shear stress in the female vasculature is improved by TNF-α antagonism
-
Arenas I.A., Xu Y., and Davidge S.T. Age-associated impairment in vasorelaxation to fluid shear stress in the female vasculature is improved by TNF-α antagonism. Am. J. Physiol. Heart Circ. Physiol. 290 (2006) H1259-H1263
-
(2006)
Am. J. Physiol. Heart Circ. Physiol.
, vol.290
-
-
Arenas, I.A.1
Xu, Y.2
Davidge, S.T.3
-
6
-
-
0038744264
-
KLOTHO allele status and the risk of early-onset occult coronary artery disease
-
Arking D.E., Becker D.M., Yanek L.R., Fallin D., Judge D.P., Moy T.F., Becker L.C., and Dietz H.C. KLOTHO allele status and the risk of early-onset occult coronary artery disease. Am. J. Hum. Genet. 72 (2003) 1154-1161
-
(2003)
Am. J. Hum. Genet.
, vol.72
, pp. 1154-1161
-
-
Arking, D.E.1
Becker, D.M.2
Yanek, L.R.3
Fallin, D.4
Judge, D.P.5
Moy, T.F.6
Becker, L.C.7
Dietz, H.C.8
-
7
-
-
18244372958
-
Association of human aging with a functional variant of klotho
-
Arking D.E., Krebsova A., Macek Sr. M., Macek Jr. M., Arking A., Mian I.S., Fried L., Hamosh A., Dey S., McIntosh I., and Dietz H.C. Association of human aging with a functional variant of klotho. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 856-861
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 856-861
-
-
Arking, D.E.1
Krebsova, A.2
Macek Sr., M.3
Macek Jr., M.4
Arking, A.5
Mian, I.S.6
Fried, L.7
Hamosh, A.8
Dey, S.9
McIntosh, I.10
Dietz, H.C.11
-
8
-
-
0035198143
-
Age dependent aneuploidy and telomere length of the human vascular endothelium
-
Aviv H., Khan M.Y., Skurnick J., Okuda K., Kimura M., Gardner J., Priolo L., and Aviv A. Age dependent aneuploidy and telomere length of the human vascular endothelium. Atherosclerosis 159 (2001) 281-287
-
(2001)
Atherosclerosis
, vol.159
, pp. 281-287
-
-
Aviv, H.1
Khan, M.Y.2
Skurnick, J.3
Okuda, K.4
Kimura, M.5
Gardner, J.6
Priolo, L.7
Aviv, A.8
-
9
-
-
36749102062
-
Targets for regulating angiogenesis in the ageing endothelium
-
Ballard V.L., and Edelberg J.M. Targets for regulating angiogenesis in the ageing endothelium. Expert Opin. Ther. Targets 11 (2007) 1385-1399
-
(2007)
Expert Opin. Ther. Targets
, vol.11
, pp. 1385-1399
-
-
Ballard, V.L.1
Edelberg, J.M.2
-
10
-
-
0028835485
-
Increased production of tumor necrosis factor and interleukin-6 by arterial wall of aged rats
-
Belmin J., Bernard C., Corman B., Merval R., Esposito B., and Tedgui A. Increased production of tumor necrosis factor and interleukin-6 by arterial wall of aged rats. Am. J. Physiol. 268 (1995) H2288-H2293
-
(1995)
Am. J. Physiol.
, vol.268
-
-
Belmin, J.1
Bernard, C.2
Corman, B.3
Merval, R.4
Esposito, B.5
Tedgui, A.6
-
11
-
-
1542781659
-
When cells get stressed: an integrative view of cellular senescence
-
Ben-Porath I., and Weinberg R.A. When cells get stressed: an integrative view of cellular senescence. J. Clin. Invest. 113 (2004) 8-13
-
(2004)
J. Clin. Invest.
, vol.113
, pp. 8-13
-
-
Ben-Porath, I.1
Weinberg, R.A.2
-
12
-
-
0142023863
-
Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels
-
Berkowitz D.E., White R., Li D., Minhas K.M., Cernetich A., Kim S., Burke S., Shoukas A.A., Nyhan D., Champion H.C., and Hare J.M. Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels. Circulation 108 (2003) 2000-2006
-
(2003)
Circulation
, vol.108
, pp. 2000-2006
-
-
Berkowitz, D.E.1
White, R.2
Li, D.3
Minhas, K.M.4
Cernetich, A.5
Kim, S.6
Burke, S.7
Shoukas, A.A.8
Nyhan, D.9
Champion, H.C.10
Hare, J.M.11
-
13
-
-
9344256749
-
Mechanisms of aging-induced impairment of endothelium-dependent relaxation: role of tetrahydrobiopterin
-
Blackwell K.A., Sorenson J.P., Richardson D.M., Smith L.A., Suda O., Nath K., and Katusic Z.S. Mechanisms of aging-induced impairment of endothelium-dependent relaxation: role of tetrahydrobiopterin. Am. J. Physiol. Heart Circ. Physiol. 287 (2004) H2448-H2453
-
(2004)
Am. J. Physiol. Heart Circ. Physiol.
, vol.287
-
-
Blackwell, K.A.1
Sorenson, J.P.2
Richardson, D.M.3
Smith, L.A.4
Suda, O.5
Nath, K.6
Katusic, Z.S.7
-
14
-
-
0141607693
-
Oral l-arginine improves endothelial function in healthy individuals older than 70 years
-
Bode-Böger S.M., Muke J., Surdacki A., Brabant G., Böger R.H., and Frölich J.C. Oral l-arginine improves endothelial function in healthy individuals older than 70 years. Vasc. Med. 8 (2003) 77-81
-
(2003)
Vasc. Med.
, vol.8
, pp. 77-81
-
-
Bode-Böger, S.M.1
Muke, J.2
Surdacki, A.3
Brabant, G.4
Böger, R.H.5
Frölich, J.C.6
-
16
-
-
0035937503
-
Pro-atherogenic factors induce telomerase inactivation in endothelial cells through an Akt-dependent mechanism
-
Breitschopf K., Zeiher A.M., and Dimmeler S. Pro-atherogenic factors induce telomerase inactivation in endothelial cells through an Akt-dependent mechanism. FEBS Lett. 493 (2001) 21-25
-
(2001)
FEBS Lett.
, vol.493
, pp. 21-25
-
-
Breitschopf, K.1
Zeiher, A.M.2
Dimmeler, S.3
-
17
-
-
26044445766
-
Ageing affects nitric oxide synthase, cyclooxygenase and oxidative stress enzymes expression differently in mesenteric resistance arteries
-
Briones A.M., Montoya N., Giraldo J., and Vila E. Ageing affects nitric oxide synthase, cyclooxygenase and oxidative stress enzymes expression differently in mesenteric resistance arteries. Auton. Autacoid. Pharmacol. 25 (2005) 155-162
-
(2005)
Auton. Autacoid. Pharmacol.
, vol.25
, pp. 155-162
-
-
Briones, A.M.1
Montoya, N.2
Giraldo, J.3
Vila, E.4
-
18
-
-
33744900322
-
Gene transfer of extracellular superoxide dismutase protects against vascular dysfunction with aging
-
Brown K.A., Chu Y., Lund D.D., Heistad D.D., and Faraci F.M. Gene transfer of extracellular superoxide dismutase protects against vascular dysfunction with aging. Am. J. Physiol. Heart Circ. Physiol. 290 (2006) H2600-H2605
-
(2006)
Am. J. Physiol. Heart Circ. Physiol.
, vol.290
-
-
Brown, K.A.1
Chu, Y.2
Lund, D.D.3
Heistad, D.D.4
Faraci, F.M.5
-
19
-
-
0033846816
-
Ageing, tumour necrosis factor-α (TNF-α) and atherosclerosis
-
Bruunsgaard H., Skinhoj P., Pedersen A.N., Schroll M., and Pedersen B.K. Ageing, tumour necrosis factor-α (TNF-α) and atherosclerosis. Clin. Exp. Immunol. 121 (2000) 255-260
-
(2000)
Clin. Exp. Immunol.
, vol.121
, pp. 255-260
-
-
Bruunsgaard, H.1
Skinhoj, P.2
Pedersen, A.N.3
Schroll, M.4
Pedersen, B.K.5
-
20
-
-
0141893558
-
Aged spontaneously hypertensive rats exhibit a selective loss of EDHF-mediated relaxation in the renal artery
-
Büssemaker E., Popp R., Fisslthaler B., Larson C.M., Fleming I., Busse R., and Brandes R.P. Aged spontaneously hypertensive rats exhibit a selective loss of EDHF-mediated relaxation in the renal artery. Hypertension 42 (2003) 562-568
-
(2003)
Hypertension
, vol.42
, pp. 562-568
-
-
Büssemaker, E.1
Popp, R.2
Fisslthaler, B.3
Larson, C.M.4
Fleming, I.5
Busse, R.6
Brandes, R.P.7
-
21
-
-
34547626336
-
The role of nitric oxide in erectile dysfunction: implications for medical therapy
-
Burnett A.L. The role of nitric oxide in erectile dysfunction: implications for medical therapy. J. Clin. Hypertens. (Greenwich) 8 Suppl. 4 (2006) 53-62
-
(2006)
J. Clin. Hypertens. (Greenwich)
, vol.8
, Issue.SUPPL. 4
, pp. 53-62
-
-
Burnett, A.L.1
-
22
-
-
0034069237
-
Cancer, aging and cellular senescence
-
Campisi J. Cancer, aging and cellular senescence. In Vivo 14 (2000) 183-188
-
(2000)
In Vivo
, vol.14
, pp. 183-188
-
-
Campisi, J.1
-
23
-
-
0032504749
-
Expression of constitutive and inducible nitric oxide synthases in the vascular wall of young and aging rats
-
Cernadas M.R., Sánchez de Miguel L., García-Durán M., González-Fernández F., Millas I., Montón M., Rodrigo J., Rico L., Fernández P., de Frutos T., Rodriguez-Feo J.A., Guerra J., Caramelo C., Casado S., and Lopez-Farre A.J. Expression of constitutive and inducible nitric oxide synthases in the vascular wall of young and aging rats. Circ. Res. 83 (1998) 279-286
-
(1998)
Circ. Res.
, vol.83
, pp. 279-286
-
-
Cernadas, M.R.1
Sánchez de Miguel, L.2
García-Durán, M.3
González-Fernández, F.4
Millas, I.5
Montón, M.6
Rodrigo, J.7
Rico, L.8
Fernández, P.9
de Frutos, T.10
Rodriguez-Feo, J.A.11
Guerra, J.12
Caramelo, C.13
Casado, S.14
Lopez-Farre, A.J.15
-
24
-
-
13444262357
-
Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease
-
Channon K.M. Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease. Trends Cardiovasc. Med. 14 (2004) 323-327
-
(2004)
Trends Cardiovasc. Med.
, vol.14
, pp. 323-327
-
-
Channon, K.M.1
-
25
-
-
33646685457
-
The molecular inflammatory process in aging
-
Chung H.Y., Sung B., Jung K.J., Zou Y., and Yu B.P. The molecular inflammatory process in aging. Antioxid. Redox Signal. 8 (2006) 572-581
-
(2006)
Antioxid. Redox Signal.
, vol.8
, pp. 572-581
-
-
Chung, H.Y.1
Sung, B.2
Jung, K.J.3
Zou, Y.4
Yu, B.P.5
-
26
-
-
0842302964
-
Biological and social predictors of immune senescence in the aged primate
-
Coe C.L. Biological and social predictors of immune senescence in the aged primate. Mech. Ageing Dev. 125 (2004) 95-98
-
(2004)
Mech. Ageing Dev.
, vol.125
, pp. 95-98
-
-
Coe, C.L.1
-
28
-
-
31344444441
-
ADMA: its role in vascular disease
-
Cooke J.P. ADMA: its role in vascular disease. Vasc. Med. 10 Suppl. 1 (2005) S11-S17
-
(2005)
Vasc. Med.
, vol.10
, Issue.SUPPL. 1
-
-
Cooke, J.P.1
-
29
-
-
33745967974
-
Altered mitochondrial energy metabolism may play a role in vascular aging
-
Csiszar A., Labinskyy N., Orosz Z., and Ungvari Z. Altered mitochondrial energy metabolism may play a role in vascular aging. Med. Hypotheses 67 (2006) 904-908
-
(2006)
Med. Hypotheses
, vol.67
, pp. 904-908
-
-
Csiszar, A.1
Labinskyy, N.2
Orosz, Z.3
Ungvari, Z.4
-
30
-
-
33847032609
-
Vasculoprotective effects of anti-tumor necrosis factor-α treatment in aging
-
Csiszar A., Labinskyy N., Smith K., Rivera A., Orosz Z., and Ungvari Z. Vasculoprotective effects of anti-tumor necrosis factor-α treatment in aging. Am. J. Pathol. 170 (2007) 388-398
-
(2007)
Am. J. Pathol.
, vol.170
, pp. 388-398
-
-
Csiszar, A.1
Labinskyy, N.2
Smith, K.3
Rivera, A.4
Orosz, Z.5
Ungvari, Z.6
-
31
-
-
21644475628
-
Role of oxidative and nitrosative stress, longevity genes and poly(ADP-ribose) polymerase in cardiovascular dysfunction associated with aging
-
Csiszar A., Pacher P., Kaley G., and Ungvari Z. Role of oxidative and nitrosative stress, longevity genes and poly(ADP-ribose) polymerase in cardiovascular dysfunction associated with aging. Curr. Vasc. Pharmacol. 3 (2005) 285-291
-
(2005)
Curr. Vasc. Pharmacol.
, vol.3
, pp. 285-291
-
-
Csiszar, A.1
Pacher, P.2
Kaley, G.3
Ungvari, Z.4
-
32
-
-
34248152614
-
The aging kidney: role of endothelial oxidative stress and inflammation
-
Csiszar A., Toth J., Peti-Peterdi J., and Ungvari Z. The aging kidney: role of endothelial oxidative stress and inflammation. Acta Physiol. Hung. 94 (2007) 107-115
-
(2007)
Acta Physiol. Hung.
, vol.94
, pp. 107-115
-
-
Csiszar, A.1
Toth, J.2
Peti-Peterdi, J.3
Ungvari, Z.4
-
33
-
-
0037076784
-
Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function
-
Csiszar A., Ungvari Z., Edwards J.G., Kaminski P., Wolin M.S., Koller A., and Kaley G. Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function. Circ. Res. 90 (2002) 1159-1166
-
(2002)
Circ. Res.
, vol.90
, pp. 1159-1166
-
-
Csiszar, A.1
Ungvari, Z.2
Edwards, J.G.3
Kaminski, P.4
Wolin, M.S.5
Koller, A.6
Kaley, G.7
-
34
-
-
0038718728
-
Aging induced proinflammatory shift in cytokine expression profile in rat coronary arteries
-
Csiszar A., Ungvari Z., Koller A., Edwards J.G., and Kaley G. Aging induced proinflammatory shift in cytokine expression profile in rat coronary arteries. FASEB J. 17 (2003) 1183-1185
-
(2003)
FASEB J.
, vol.17
, pp. 1183-1185
-
-
Csiszar, A.1
Ungvari, Z.2
Koller, A.3
Edwards, J.G.4
Kaley, G.5
-
35
-
-
1842509760
-
Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging
-
Csiszar A., Ungvari Z., Koller A., Edwards J.G., and Kaley G. Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging. Physiol. Genom. 17 (2004) 21-30
-
(2004)
Physiol. Genom.
, vol.17
, pp. 21-30
-
-
Csiszar, A.1
Ungvari, Z.2
Koller, A.3
Edwards, J.G.4
Kaley, G.5
-
36
-
-
55449136486
-
Inflammation and endothelial dysfunction during aging: role of NF-κB
-
Csiszar A., Wang M., Lakatta E.G., and Ungvari Z. Inflammation and endothelial dysfunction during aging: role of NF-κB. J. Appl. Physiol. 105 (2008) 1333-1341
-
(2008)
J. Appl. Physiol.
, vol.105
, pp. 1333-1341
-
-
Csiszar, A.1
Wang, M.2
Lakatta, E.G.3
Ungvari, Z.4
-
37
-
-
0030472175
-
Impairment of vascular function is associated with an age-related increase of lipid peroxidation in rats
-
Davidge S.T., Hubel C.A., and McLaughlin M.K. Impairment of vascular function is associated with an age-related increase of lipid peroxidation in rats. Am. J. Physiol. 271 (1996) R1625-R1631
-
(1996)
Am. J. Physiol.
, vol.271
-
-
Davidge, S.T.1
Hubel, C.A.2
McLaughlin, M.K.3
-
38
-
-
28944445413
-
Improvement of age-related endothelial dysfunction by simvastatin: effect on NO and COX pathways
-
De Sotomayor M.A., Pérez-Guerrero C., Herrrera M.D., Jimenez L., Marín R., Marhuenda E., and Andriantsitohaina R. Improvement of age-related endothelial dysfunction by simvastatin: effect on NO and COX pathways. Br. J. Pharmacol. 146 (2005) 1130-1138
-
(2005)
Br. J. Pharmacol.
, vol.146
, pp. 1130-1138
-
-
De Sotomayor, M.A.1
Pérez-Guerrero, C.2
Herrrera, M.D.3
Jimenez, L.4
Marín, R.5
Marhuenda, E.6
Andriantsitohaina, R.7
-
39
-
-
39449118560
-
Ageing diminishes endothelium-dependent vasodilatation and tetrahydrobiopterin content in rat skeletal muscle arterioles
-
Delp M.D., Behnke B.J., Spier S.A., Wu G., and Muller-Delp J.M. Ageing diminishes endothelium-dependent vasodilatation and tetrahydrobiopterin content in rat skeletal muscle arterioles. J. Physiol. 586 (2008) 1161-1168
-
(2008)
J. Physiol.
, vol.586
, pp. 1161-1168
-
-
Delp, M.D.1
Behnke, B.J.2
Spier, S.A.3
Wu, G.4
Muller-Delp, J.M.5
-
40
-
-
31744439108
-
Impaired plasma nitric oxide availability and extracellular superoxide dismutase activity in healthy humans with advancing age
-
Di Massimo C., Scarpelli P., Di Lorenzo N., Caimi G., di Orio F., and Ciancarelli M.G. Impaired plasma nitric oxide availability and extracellular superoxide dismutase activity in healthy humans with advancing age. Life Sci. 78 (2006) 1163-1167
-
(2006)
Life Sci.
, vol.78
, pp. 1163-1167
-
-
Di Massimo, C.1
Scarpelli, P.2
Di Lorenzo, N.3
Caimi, G.4
di Orio, F.5
Ciancarelli, M.G.6
-
41
-
-
34250216014
-
Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-kappaB
-
Donato A.J., Eskurza I., Silver A.E., Levy A.S., Pierce G.L., Gates P.E., and Seals D.R. Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-kappaB. Circ. Res. 100 (2007) 1659-1666
-
(2007)
Circ. Res.
, vol.100
, pp. 1659-1666
-
-
Donato, A.J.1
Eskurza, I.2
Silver, A.E.3
Levy, A.S.4
Pierce, G.L.5
Gates, P.E.6
Seals, D.R.7
-
42
-
-
16344374717
-
The effects of aging and exercise training on endothelin-1 vasoconstrictor responses in rat skeletal muscle arterioles
-
Donato A.J., Lesniewski L.A., and Delp M.D. The effects of aging and exercise training on endothelin-1 vasoconstrictor responses in rat skeletal muscle arterioles. Cardiovasc. Res. 66 (2005) 393-401
-
(2005)
Cardiovasc. Res.
, vol.66
, pp. 393-401
-
-
Donato, A.J.1
Lesniewski, L.A.2
Delp, M.D.3
-
43
-
-
60349113539
-
Mechanisms of endothelial senescence
-
Erusalimsky J.D., and Skene C. Mechanisms of endothelial senescence. Exp. Physiol. 94 (2009) 299-304
-
(2009)
Exp. Physiol.
, vol.94
, pp. 299-304
-
-
Erusalimsky, J.D.1
Skene, C.2
-
44
-
-
27844587829
-
Tetrahydrobiopterin augments endothelium-dependent dilatation in sedentary but not in habitually exercising older adults
-
Eskurza I., Myerburgh L.A., Kahn Z.D., and Seals D.R. Tetrahydrobiopterin augments endothelium-dependent dilatation in sedentary but not in habitually exercising older adults. J. Physiol. 568 (2005) 1057-1065
-
(2005)
J. Physiol.
, vol.568
, pp. 1057-1065
-
-
Eskurza, I.1
Myerburgh, L.A.2
Kahn, Z.D.3
Seals, D.R.4
-
45
-
-
3042691909
-
Invited review: aging and the cardiovascular system
-
Ferrari A.U., Radaelli A., and Centola M. Invited review: aging and the cardiovascular system. J. Appl. Physiol. 95 (2003) 2591-2597
-
(2003)
J. Appl. Physiol.
, vol.95
, pp. 2591-2597
-
-
Ferrari, A.U.1
Radaelli, A.2
Centola, M.3
-
46
-
-
33751525147
-
Janus-faced role of endothelial NO synthase in vascular disease: uncoupling of oxygen reduction from NO synthesis and its pharmacological reversal
-
Förstermann U. Janus-faced role of endothelial NO synthase in vascular disease: uncoupling of oxygen reduction from NO synthesis and its pharmacological reversal. Biol. Chem. 387 (2006) 1521-1533
-
(2006)
Biol. Chem.
, vol.387
, pp. 1521-1533
-
-
Förstermann, U.1
-
48
-
-
33846159514
-
Impaired flow-mediated dilation with age is not explained by l-arginine bioavailability or endothelial asymmetric dimethylarginine protein expression
-
Gates P.E., Boucher M.L., Silver A.E., Monahan K.D., and Seals D.R. Impaired flow-mediated dilation with age is not explained by l-arginine bioavailability or endothelial asymmetric dimethylarginine protein expression. J. Appl. Physiol. 102 (2007) 63-71
-
(2007)
J. Appl. Physiol.
, vol.102
, pp. 63-71
-
-
Gates, P.E.1
Boucher, M.L.2
Silver, A.E.3
Monahan, K.D.4
Seals, D.R.5
-
49
-
-
36649019329
-
Endothelium-derived hyperpolarizing factor as an in vivo back-up mechanism in the cutaneous microcirculation in old mice
-
Gaubert M.L., Sigaudo-Roussel D., Tartas M., Berrut G., Saumet J.L., and Fromy B. Endothelium-derived hyperpolarizing factor as an in vivo back-up mechanism in the cutaneous microcirculation in old mice. J. Physiol. 585 (2007) 617-626
-
(2007)
J. Physiol.
, vol.585
, pp. 617-626
-
-
Gaubert, M.L.1
Sigaudo-Roussel, D.2
Tartas, M.3
Berrut, G.4
Saumet, J.L.5
Fromy, B.6
-
50
-
-
33750523632
-
NF-kappaB activation by reactive oxygen species: fifteen years later
-
Gloire G., Legrand-Poels S., and Piette J. NF-kappaB activation by reactive oxygen species: fifteen years later. Biochem. Pharmacol. 72 (2006) 1493-1505
-
(2006)
Biochem. Pharmacol.
, vol.72
, pp. 1493-1505
-
-
Gloire, G.1
Legrand-Poels, S.2
Piette, J.3
-
51
-
-
0034817009
-
Increased expression of endothelin-1 and inducible nitric oxide synthase isoform II in aging arteries in vivo: implications for atherosclerosis
-
Goettsch W., Lattmann T., Amann K., Szibor M., Morawietz H., Munter K., Muller S.P., Shaw S., and Barton M. Increased expression of endothelin-1 and inducible nitric oxide synthase isoform II in aging arteries in vivo: implications for atherosclerosis. Biochem. Biophys. Res. Commun. 280 (2001) 908-913
-
(2001)
Biochem. Biophys. Res. Commun.
, vol.280
, pp. 908-913
-
-
Goettsch, W.1
Lattmann, T.2
Amann, K.3
Szibor, M.4
Morawietz, H.5
Munter, K.6
Muller, S.P.7
Shaw, S.8
Barton, M.9
-
52
-
-
0033770480
-
Angiotensin-converting enzyme inhibitor prevents age-related endothelial dysfunction
-
Goto K., Fujii K., Onaka U., Abe I., and Fujishima M. Angiotensin-converting enzyme inhibitor prevents age-related endothelial dysfunction. Hypertension 36 (2000) 581-587
-
(2000)
Hypertension
, vol.36
, pp. 581-587
-
-
Goto, K.1
Fujii, K.2
Onaka, U.3
Abe, I.4
Fujishima, M.5
-
53
-
-
0038721199
-
Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707
-
Haendeler J., Hoffmann J., Brandes R.P., Zeiher A.M., and Dimmeler S. Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707. Mol. Cell. Biol. 23 (2003) 4598-4610
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 4598-4610
-
-
Haendeler, J.1
Hoffmann, J.2
Brandes, R.P.3
Zeiher, A.M.4
Dimmeler, S.5
-
54
-
-
0035097953
-
Superoxide excess in hypertension and aging: a common cause of endothelial dysfunction
-
Hamilton C.A., Brosnan M.J., McIntyre M., Graham D., and Dominiczak A.F. Superoxide excess in hypertension and aging: a common cause of endothelial dysfunction. Hypertension 37 (2000) 529-534
-
(2000)
Hypertension
, vol.37
, pp. 529-534
-
-
Hamilton, C.A.1
Brosnan, M.J.2
McIntyre, M.3
Graham, D.4
Dominiczak, A.F.5
-
55
-
-
33847781131
-
Amelioration of progressive renal injury by genetic manipulation of Klotho gene
-
Haruna Y., Kashihara N., Satoh M., Tomita N., Namikoshi T., Sasaki T., Fujimori T., Xie P., and Kanwar Y.S. Amelioration of progressive renal injury by genetic manipulation of Klotho gene. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 2331-2336
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 2331-2336
-
-
Haruna, Y.1
Kashihara, N.2
Satoh, M.3
Tomita, N.4
Namikoshi, T.5
Sasaki, T.6
Fujimori, T.7
Xie, P.8
Kanwar, Y.S.9
-
56
-
-
33750944018
-
Endothelial cellular senescence is inhibited by nitric oxide: implications in atherosclerosis associated with menopause and diabetes
-
Hayashi T., Matsui-Hirai H., Miyazaki-Akita A., Fukatsu A., Funami J., Ding Q.F., Kamalanathan S., Hattori Y., Ignarro L.J., and Iguchi A. Endothelial cellular senescence is inhibited by nitric oxide: implications in atherosclerosis associated with menopause and diabetes. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 17018-17023
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 17018-17023
-
-
Hayashi, T.1
Matsui-Hirai, H.2
Miyazaki-Akita, A.3
Fukatsu, A.4
Funami, J.5
Ding, Q.F.6
Kamalanathan, S.7
Hattori, Y.8
Ignarro, L.J.9
Iguchi, A.10
-
57
-
-
56049085092
-
Nitric oxide and endothelial cellular senescence
-
Hayashi T., Yano K., Matsui-Hirai H., Yokoo H., Hattori Y., and Iguchi A. Nitric oxide and endothelial cellular senescence. Pharmacol. Ther. 120 (2008) 333-339
-
(2008)
Pharmacol. Ther.
, vol.120
, pp. 333-339
-
-
Hayashi, T.1
Yano, K.2
Matsui-Hirai, H.3
Yokoo, H.4
Hattori, Y.5
Iguchi, A.6
-
58
-
-
0035224729
-
Cyclo-oxygenase-1 and -2 contribution to endothelial dysfunction in ageing
-
Heymes C., Habib A., Yang D., Mathieu E., Marotte F., Samuel J., and Boulanger C.M. Cyclo-oxygenase-1 and -2 contribution to endothelial dysfunction in ageing. Br. J. Pharmacol. 131 (2000) 804-810
-
(2000)
Br. J. Pharmacol.
, vol.131
, pp. 804-810
-
-
Heymes, C.1
Habib, A.2
Yang, D.3
Mathieu, E.4
Marotte, F.5
Samuel, J.6
Boulanger, C.M.7
-
59
-
-
33646402907
-
Tetrahydrobiopterin improves aging-related impairment of endothelium-dependent vasodilation through increase in nitric oxide production
-
Higashi Y., Sasaki S., Nakagawa K., Kimura M., Noma K., Hara K., Jitsuiki D., Goto C., Oshima T., Chayama K., and Yoshizumi M. Tetrahydrobiopterin improves aging-related impairment of endothelium-dependent vasodilation through increase in nitric oxide production. Atherosclerosis 186 (2006) 390-395
-
(2006)
Atherosclerosis
, vol.186
, pp. 390-395
-
-
Higashi, Y.1
Sasaki, S.2
Nakagawa, K.3
Kimura, M.4
Noma, K.5
Hara, K.6
Jitsuiki, D.7
Goto, C.8
Oshima, T.9
Chayama, K.10
Yoshizumi, M.11
-
60
-
-
33745740349
-
l-Arginine supplementation or arginase inhibition augments reflex cutaneous vasodilatation in aged human skin
-
Holowatz L.A., Thompson C.S., and Kenney W.L. l-Arginine supplementation or arginase inhibition augments reflex cutaneous vasodilatation in aged human skin. J. Physiol. 574 (2006) 573-581
-
(2006)
J. Physiol.
, vol.574
, pp. 573-581
-
-
Holowatz, L.A.1
Thompson, C.S.2
Kenney, W.L.3
-
61
-
-
28844474827
-
Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells
-
Ikushima M., Rakugi H., Ishikawa K., Maekawa Y., Yamamoto K., Ohta J., Chihara Y., Kida I., and Ogihara T. Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells. Biochem. Biophys. Res. Commun. 339 (2006) 827-832
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.339
, pp. 827-832
-
-
Ikushima, M.1
Rakugi, H.2
Ishikawa, K.3
Maekawa, Y.4
Yamamoto, K.5
Ohta, J.6
Chihara, Y.7
Kida, I.8
Ogihara, T.9
-
62
-
-
38849134824
-
Upregulation of cortical COX-2 in salt-sensitive hypertension: role of angiotensin II and reactive oxygen species
-
Jaimes J.A., Zhou M.S., Pearse D.D., Puzis L., and Raij L. Upregulation of cortical COX-2 in salt-sensitive hypertension: role of angiotensin II and reactive oxygen species. Am. J. Physiol. Renal Physiol. 294 (2008) F385-F392
-
(2008)
Am. J. Physiol. Renal Physiol.
, vol.294
-
-
Jaimes, J.A.1
Zhou, M.S.2
Pearse, D.D.3
Puzis, L.4
Raij, L.5
-
63
-
-
0036492013
-
Angiotensin II receptor antagonist improves age-related endothelial dysfunction
-
Kansui Y., Fujii K., Goto K., Abe I., and Iida M. Angiotensin II receptor antagonist improves age-related endothelial dysfunction. J. Hypertens. 20 (2002) 439-446
-
(2002)
J. Hypertens.
, vol.20
, pp. 439-446
-
-
Kansui, Y.1
Fujii, K.2
Goto, K.3
Abe, I.4
Iida, M.5
-
64
-
-
0344088466
-
Asymmetric dimethylarginine, blood pressure, and renal perfusion in elderly subjects
-
Kielstein J.T., Bode-Böger S.M., Frölich J.C., Ritz E., Haller H., and Fliser D. Asymmetric dimethylarginine, blood pressure, and renal perfusion in elderly subjects. Circulation 107 (2003) 1891-1895
-
(2003)
Circulation
, vol.107
, pp. 1891-1895
-
-
Kielstein, J.T.1
Bode-Böger, S.M.2
Frölich, J.C.3
Ritz, E.4
Haller, H.5
Fliser, D.6
-
65
-
-
64849104126
-
Induction of cellular senescence by secretory phospholipase A2 in human dermal fibroblasts through an ROS-mediated p53 pathway
-
Kim H.J., Kim K.S., Kim S.H., Baek S.H., Kim H.Y., Lee C., and Kim J.R. Induction of cellular senescence by secretory phospholipase A2 in human dermal fibroblasts through an ROS-mediated p53 pathway. J. Gerontol. A Biol. Sci. Med. Sci. 64 (2009) 351-362
-
(2009)
J. Gerontol. A Biol. Sci. Med. Sci.
, vol.64
, pp. 351-362
-
-
Kim, H.J.1
Kim, K.S.2
Kim, S.H.3
Baek, S.H.4
Kim, H.Y.5
Lee, C.6
Kim, J.R.7
-
66
-
-
0034810211
-
Severely reduced production of klotho in human chronic renal failure kidney
-
Koh N., Fujimori T., Nishiguchi S., Tamori A., Shiomi S., Nakatani T., Sugimura K., Kishimoto T., Kinoshita S., Kuroki T., and Nabeshima Y. Severely reduced production of klotho in human chronic renal failure kidney. Biochem. Biophys. Res. Commun. 280 (2001) 1015-1020
-
(2001)
Biochem. Biophys. Res. Commun.
, vol.280
, pp. 1015-1020
-
-
Koh, N.1
Fujimori, T.2
Nishiguchi, S.3
Tamori, A.4
Shiomi, S.5
Nakatani, T.6
Sugimura, K.7
Kishimoto, T.8
Kinoshita, S.9
Kuroki, T.10
Nabeshima, Y.11
-
67
-
-
40949090174
-
Reduced nitric oxide causes age-associated impairment of circadian rhythmicity
-
Kunieda T., Minamino T., Miura K., Katsuno T., Tateno K., Miyauchi H., Kaneko S., Bradfield C.A., FitzGerald G.A., and Komuro I. Reduced nitric oxide causes age-associated impairment of circadian rhythmicity. Circ. Res. 102 (2008) 607-614
-
(2008)
Circ. Res.
, vol.102
, pp. 607-614
-
-
Kunieda, T.1
Minamino, T.2
Miura, K.3
Katsuno, T.4
Tateno, K.5
Miyauchi, H.6
Kaneko, S.7
Bradfield, C.A.8
FitzGerald, G.A.9
Komuro, I.10
-
68
-
-
33748090908
-
Klotho as a regulator of fibroblast growth factor signaling and phosphate/calcium metabolism
-
Kuro-o M. Klotho as a regulator of fibroblast growth factor signaling and phosphate/calcium metabolism. Curr. Opin. Nephrol. Hypertens. 15 (2006) 437-441
-
(2006)
Curr. Opin. Nephrol. Hypertens.
, vol.15
, pp. 437-441
-
-
Kuro-o, M.1
-
69
-
-
77949269979
-
-
Kuro-o M., in press. Klotho and aging. Biochim. Biophys. Acta. (available online).
-
Kuro-o M., in press. Klotho and aging. Biochim. Biophys. Acta. (available online).
-
-
-
-
70
-
-
0030724491
-
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
-
Kuro-o M., Matsumura Y., Aizawa H., Kawaguchi H., Suga T., Utsugi T., Ohyama Y., Kurabayashi M., Kaname T., Kume E., Iwasaki H., Iida A., Shiraki-Iida T., Nishikawa S., Nagai R., and Nabeshima Y.I. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390 (1997) 45-51
-
(1997)
Nature
, vol.390
, pp. 45-51
-
-
Kuro-o, M.1
Matsumura, Y.2
Aizawa, H.3
Kawaguchi, H.4
Suga, T.5
Utsugi, T.6
Ohyama, Y.7
Kurabayashi, M.8
Kaname, T.9
Kume, E.10
Iwasaki, H.11
Iida, A.12
Shiraki-Iida, T.13
Nishikawa, S.14
Nagai, R.15
Nabeshima, Y.I.16
-
71
-
-
58349115748
-
The Klotho gene family as a regulator of endocrine fibroblast growth factors
-
Kurosu H., and Kuro-o M. The Klotho gene family as a regulator of endocrine fibroblast growth factors. Mol. Cell. Endocrinol. 299 (2009) 72-78
-
(2009)
Mol. Cell. Endocrinol.
, vol.299
, pp. 72-78
-
-
Kurosu, H.1
Kuro-o, M.2
-
72
-
-
24944481544
-
Suppression of aging in mice by the hormone Klotho
-
Kurosu H., Yamamoto M., Clark J.D., Pastor J.V., Nandi A., Gurnani P., McGuinness O.P., Chikuda H., Yamaguchi M., Kawaguchi H., Shimomura I., Takayama Y., Herz J., Kahn C.R., Rosenblatt K.P., and Kuro-o M. Suppression of aging in mice by the hormone Klotho. Science 309 (2005) 1829-1833
-
(2005)
Science
, vol.309
, pp. 1829-1833
-
-
Kurosu, H.1
Yamamoto, M.2
Clark, J.D.3
Pastor, J.V.4
Nandi, A.5
Gurnani, P.6
McGuinness, O.P.7
Chikuda, H.8
Yamaguchi, M.9
Kawaguchi, H.10
Shimomura, I.11
Takayama, Y.12
Herz, J.13
Kahn, C.R.14
Rosenblatt, K.P.15
Kuro-o, M.16
-
73
-
-
0037690621
-
Fibroblast growth factor-2, but not vascular endothelial growth factor, upregulates telomerase activity in human endothelial cells
-
Kurz D.J., Hong Y., Trivier E., Huang H.L., Decary S., Zang G.H., Lüscher T.F., and Erusalimsky J.D. Fibroblast growth factor-2, but not vascular endothelial growth factor, upregulates telomerase activity in human endothelial cells. Arterioscler. Thromb. Vasc. Biol. 23 (2003) 748-754
-
(2003)
Arterioscler. Thromb. Vasc. Biol.
, vol.23
, pp. 748-754
-
-
Kurz, D.J.1
Hong, Y.2
Trivier, E.3
Huang, H.L.4
Decary, S.5
Zang, G.H.6
Lüscher, T.F.7
Erusalimsky, J.D.8
-
74
-
-
33645958280
-
Vascular dysfunction in aging: potential effects of resveratrol, an anti-inflammatory phytoestrogen
-
Labinskyy N., Csiszar A., Veress G., Stef G., Pacher P., Oroszi G., Wu J., and Ungvari Z. Vascular dysfunction in aging: potential effects of resveratrol, an anti-inflammatory phytoestrogen. Curr. Med. Chem. 13 (2006) 989-996
-
(2006)
Curr. Med. Chem.
, vol.13
, pp. 989-996
-
-
Labinskyy, N.1
Csiszar, A.2
Veress, G.3
Stef, G.4
Pacher, P.5
Oroszi, G.6
Wu, J.7
Ungvari, Z.8
-
75
-
-
0037422592
-
Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises. I. Aging arteries: a "set up" for vascular disease
-
Lakatta E.G., and Levy D. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises. I. Aging arteries: a "set up" for vascular disease. Circulation 107 (2003) 139-146
-
(2003)
Circulation
, vol.107
, pp. 139-146
-
-
Lakatta, E.G.1
Levy, D.2
-
76
-
-
0035814951
-
Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin
-
Laursen J.B., Somers M., Kurz S., McCann L., Warnholtz A., Freeman B.A., Tarpey M., Fukai T., and Harrison D.G. Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin. Circulation 103 (2001) 1282-1288
-
(2001)
Circulation
, vol.103
, pp. 1282-1288
-
-
Laursen, J.B.1
Somers, M.2
Kurz, S.3
McCann, L.4
Warnholtz, A.5
Freeman, B.A.6
Tarpey, M.7
Fukai, T.8
Harrison, D.G.9
-
77
-
-
30944434869
-
Loss of nitric oxide and endothelial-derived hyperpolarizing factor-mediated responses in aging
-
Long D.A., Newaz M.A., Prabhakar S.S., Price K.L., Truong L.D., Feng L., Mu W., Oyekan A.O., and Johnson R.J. Loss of nitric oxide and endothelial-derived hyperpolarizing factor-mediated responses in aging. Kidney Int. 68 (2005) 2154-2163
-
(2005)
Kidney Int.
, vol.68
, pp. 2154-2163
-
-
Long, D.A.1
Newaz, M.A.2
Prabhakar, S.S.3
Price, K.L.4
Truong, L.D.5
Feng, L.6
Mu, W.7
Oyekan, A.O.8
Johnson, R.J.9
-
78
-
-
0033180413
-
Age-related changes in the signaling and function of vascular smooth muscle cells
-
Lundberg M.S., and Crow M.T. Age-related changes in the signaling and function of vascular smooth muscle cells. Exp. Gerontol. 34 (1999) 549-557
-
(1999)
Exp. Gerontol.
, vol.34
, pp. 549-557
-
-
Lundberg, M.S.1
Crow, M.T.2
-
79
-
-
33947512416
-
Mitochondrial dysfunction in atherosclerosis
-
Madamanchi N.R., and Runge M.S. Mitochondrial dysfunction in atherosclerosis. Circ. Res. 100 (2007) 460-473
-
(2007)
Circ. Res.
, vol.100
, pp. 460-473
-
-
Madamanchi, N.R.1
Runge, M.S.2
-
80
-
-
10744223804
-
Aerobic exercise training reduces plasma endothelin-1 concentration in older women
-
Maeda S., Tanabe T., Miyauchi T., Otsuki T., Sugawara J., Iemitsu M., Kuno S., Ajisaka R., Yamaguchi I., and Matsuda M. Aerobic exercise training reduces plasma endothelin-1 concentration in older women. J. Appl. Physiol. 95 (2003) 336-341
-
(2003)
J. Appl. Physiol.
, vol.95
, pp. 336-341
-
-
Maeda, S.1
Tanabe, T.2
Miyauchi, T.3
Otsuki, T.4
Sugawara, J.5
Iemitsu, M.6
Kuno, S.7
Ajisaka, R.8
Yamaguchi, I.9
Matsuda, M.10
-
81
-
-
70149098681
-
Klotho suppresses TNF-alpha-induced expression of adhesion molecules in the endothelium and attenuates NF-kappaB activation
-
Maekawa Y., Ishikawa K., Yasuda O., Oguro R., Hanasaki H., Kida I., Takemura Y., Ohishi M., Katsuya T., and Rakugi H. Klotho suppresses TNF-alpha-induced expression of adhesion molecules in the endothelium and attenuates NF-kappaB activation. Endocrine 35 (2009) 341-346
-
(2009)
Endocrine
, vol.35
, pp. 341-346
-
-
Maekawa, Y.1
Ishikawa, K.2
Yasuda, O.3
Oguro, R.4
Hanasaki, H.5
Kida, I.6
Takemura, Y.7
Ohishi, M.8
Katsuya, T.9
Rakugi, H.10
-
82
-
-
0028918559
-
Roles of nitric oxide and endothelium-derived hyperpolarizing factor in vasorelaxant effect of acetylcholine as influenced by aging and hypertension
-
Mantelli L., Amerini S., and Ledda F. Roles of nitric oxide and endothelium-derived hyperpolarizing factor in vasorelaxant effect of acetylcholine as influenced by aging and hypertension. J. Cardiovasc. Pharmacol. 25 (1995) 595-602
-
(1995)
J. Cardiovasc. Pharmacol.
, vol.25
, pp. 595-602
-
-
Mantelli, L.1
Amerini, S.2
Ledda, F.3
-
83
-
-
0035955754
-
e NOS activity is reduced in senescent human endothelial cells: preservation by hTERT immortalization
-
Matsushita H., Chang E., Glassford A.J., Cooke J.P., Chiu C.P., and Tsao P.S. e NOS activity is reduced in senescent human endothelial cells: preservation by hTERT immortalization. Circ. Res. 89 (2001) 793-798
-
(2001)
Circ. Res.
, vol.89
, pp. 793-798
-
-
Matsushita, H.1
Chang, E.2
Glassford, A.J.3
Cooke, J.P.4
Chiu, C.P.5
Tsao, P.S.6
-
84
-
-
0038171187
-
Age-related endothelial dysfunction: potential implications for pharmacotherapy
-
Matz R.L., and Andriantsitohaina R. Age-related endothelial dysfunction: potential implications for pharmacotherapy. Drugs Aging 20 (2003) 527-550
-
(2003)
Drugs Aging
, vol.20
, pp. 527-550
-
-
Matz, R.L.1
Andriantsitohaina, R.2
-
85
-
-
0033778214
-
Vascular bed heterogeneity in age-related endothelial dysfunction with respect to NO and eicosanoids
-
Matz R.L., de Sotomayor M.A., Schott C., Stoclet J.C., and Andriantsitohaina R. Vascular bed heterogeneity in age-related endothelial dysfunction with respect to NO and eicosanoids. Br. J. Pharmacol. 131 (2000) 303-311
-
(2000)
Br. J. Pharmacol.
, vol.131
, pp. 303-311
-
-
Matz, R.L.1
de Sotomayor, M.A.2
Schott, C.3
Stoclet, J.C.4
Andriantsitohaina, R.5
-
86
-
-
0033982738
-
Age-related endothelial dysfunction with respect to NO, endothelium-derived hyperpolarizing factor and cyclooxygenase products
-
Matz R.L., Schott C., Stoclet J.C., and Andriantsitohaina R. Age-related endothelial dysfunction with respect to NO, endothelium-derived hyperpolarizing factor and cyclooxygenase products. Physiol. Res. 49 (2000) 11-18
-
(2000)
Physiol. Res.
, vol.49
, pp. 11-18
-
-
Matz, R.L.1
Schott, C.2
Stoclet, J.C.3
Andriantsitohaina, R.4
-
87
-
-
49749145970
-
FGF-23-Klotho signaling stimulates proliferation and prevents vitamin D-induced apoptosis
-
Medici D., Razzaque M.S., Deluca S., Rector T.L., Hou B., Kang K., Goetz R., Mohammadi M., Kuro O.M., Olsen B.R., and Lanske B. FGF-23-Klotho signaling stimulates proliferation and prevents vitamin D-induced apoptosis. J. Cell Biol. 182 (2008) 459-465
-
(2008)
J. Cell Biol.
, vol.182
, pp. 459-465
-
-
Medici, D.1
Razzaque, M.S.2
Deluca, S.3
Rector, T.L.4
Hou, B.5
Kang, K.6
Goetz, R.7
Mohammadi, M.8
Kuro, O.M.9
Olsen, B.R.10
Lanske, B.11
-
88
-
-
33846121333
-
Vascular cell senescence: contribution to atherosclerosis
-
Minamino T., and Komuro I. Vascular cell senescence: contribution to atherosclerosis. Circ. Res. 100 (2007) 15-26
-
(2007)
Circ. Res.
, vol.100
, pp. 15-26
-
-
Minamino, T.1
Komuro, I.2
-
89
-
-
0036739890
-
Inhibition of renin-angiotensin system ameliorates endothelial dysfunction associated with aging in rats
-
Mukai Y., Shimokawa H., Higashi M., Morikawa K., Matoba T., Hiroki J., Kunihiro I., Talukder H.M., and Takeshita A. Inhibition of renin-angiotensin system ameliorates endothelial dysfunction associated with aging in rats. Arterioscler. Thromb. Vasc. Biol. 22 (2002) 1445-1450
-
(2002)
Arterioscler. Thromb. Vasc. Biol.
, vol.22
, pp. 1445-1450
-
-
Mukai, Y.1
Shimokawa, H.2
Higashi, M.3
Morikawa, K.4
Matoba, T.5
Hiroki, J.6
Kunihiro, I.7
Talukder, H.M.8
Takeshita, A.9
-
90
-
-
27644533791
-
Klotho gene polymorphisms are associated with osteocalcin levels but not bone density of aged postmenopausal women
-
Mullin B.H., Wilson S.G., Islam F.M., Calautti M., Dick I.M., Devine A., and Prince R.L. Klotho gene polymorphisms are associated with osteocalcin levels but not bone density of aged postmenopausal women. Calcif. Tissue Int. 77 (2005) 145-151
-
(2005)
Calcif. Tissue Int.
, vol.77
, pp. 145-151
-
-
Mullin, B.H.1
Wilson, S.G.2
Islam, F.M.3
Calautti, M.4
Dick, I.M.5
Devine, A.6
Prince, R.L.7
-
91
-
-
59649091992
-
In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23)-mediated regulation of systemic phosphate homeostasis
-
Nakatani T., Sarraj B., Ohnishi M., Densmore M.J., Taguchi T., Goetz R., Mohammadi M., Lanske B., and Razzaque M.S. In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23)-mediated regulation of systemic phosphate homeostasis. FASEB J. 23 (2009) 433-441
-
(2009)
FASEB J.
, vol.23
, pp. 433-441
-
-
Nakatani, T.1
Sarraj, B.2
Ohnishi, M.3
Densmore, M.J.4
Taguchi, T.5
Goetz, R.6
Mohammadi, M.7
Lanske, B.8
Razzaque, M.S.9
-
92
-
-
0030808065
-
The ratio of formation of prostacyclin/thromboxane A2 in HUVEC decreased in each subsequent passage
-
Neubert K., Haberland A., Kruse I., Wirth M., and Schimke I. The ratio of formation of prostacyclin/thromboxane A2 in HUVEC decreased in each subsequent passage. Prostaglandins 54 (1997) 447-462
-
(1997)
Prostaglandins
, vol.54
, pp. 447-462
-
-
Neubert, K.1
Haberland, A.2
Kruse, I.3
Wirth, M.4
Schimke, I.5
-
93
-
-
33749819577
-
Oxidative stress-associated vascular aging is xanthine oxidase-dependent but not NAD(P)H oxidase-dependent
-
Newaz M.A., Yousefipour Z., and Oyekan A. Oxidative stress-associated vascular aging is xanthine oxidase-dependent but not NAD(P)H oxidase-dependent. J. Cardiovasc. Pharmacol. 48 (2006) 88-94
-
(2006)
J. Cardiovasc. Pharmacol.
, vol.48
, pp. 88-94
-
-
Newaz, M.A.1
Yousefipour, Z.2
Oyekan, A.3
-
94
-
-
12144287941
-
Telomere shortening in human coronary artery diseases
-
Ogami M., Ikura Y., Ohsawa M., Matsuo T., Kayo S., Yoshimi N., Hai E., Shirai N., Ehara S., Komatsu R., Naruko T., and Ueda M. Telomere shortening in human coronary artery diseases. Arterioscler. Thromb. Vasc. Biol. 24 (2004) 546-550
-
(2004)
Arterioscler. Thromb. Vasc. Biol.
, vol.24
, pp. 546-550
-
-
Ogami, M.1
Ikura, Y.2
Ohsawa, M.3
Matsuo, T.4
Kayo, S.5
Yoshimi, N.6
Hai, E.7
Shirai, N.8
Ehara, S.9
Komatsu, R.10
Naruko, T.11
Ueda, M.12
-
95
-
-
33745234267
-
NADPH oxidases are in part responsible for increased cardiovascular superoxide production during aging
-
Outdo A., Martin C., Busseuil D., Vergely C., Demaison L., and Rochette L. NADPH oxidases are in part responsible for increased cardiovascular superoxide production during aging. Free Radic. Biol. Med. 40 (2006) 2214-2222
-
(2006)
Free Radic. Biol. Med.
, vol.40
, pp. 2214-2222
-
-
Outdo, A.1
Martin, C.2
Busseuil, D.3
Vergely, C.4
Demaison, L.5
Rochette, L.6
-
96
-
-
0036215470
-
Endothelial dysfunction in aging animals: the role of poly(ADP-ribose) polymerase activation
-
Pacher P., Mabley J.G., Soriano F.G., Liaudet L., Komjáti K., and Szabó C. Endothelial dysfunction in aging animals: the role of poly(ADP-ribose) polymerase activation. Br. J. Pharmacol. 135 (2002) 1347-1350
-
(2002)
Br. J. Pharmacol.
, vol.135
, pp. 1347-1350
-
-
Pacher, P.1
Mabley, J.G.2
Soriano, F.G.3
Liaudet, L.4
Komjáti, K.5
Szabó, C.6
-
97
-
-
2442439102
-
Aging enhances vascular dysfunction induced by the Alzheimer's peptide beta-amyloid
-
Price J.M., Hellermann A., Hellermann G., and Sutton E.T. Aging enhances vascular dysfunction induced by the Alzheimer's peptide beta-amyloid. Neurol. Res. 26 (2004) 305-311
-
(2004)
Neurol. Res.
, vol.26
, pp. 305-311
-
-
Price, J.M.1
Hellermann, A.2
Hellermann, G.3
Sutton, E.T.4
-
98
-
-
37349026906
-
HDL slowing down endothelial progenitor cells senescence: a novel anti-atherogenic property of HDL
-
Pu D.R., and Liu L. HDL slowing down endothelial progenitor cells senescence: a novel anti-atherogenic property of HDL. Med. Hypotheses 70 (2008) 338-342
-
(2008)
Med. Hypotheses
, vol.70
, pp. 338-342
-
-
Pu, D.R.1
Liu, L.2
-
99
-
-
34248584872
-
Single dose treatment with PARP-inhibitor INO-1001 improves aging-associated cardiac and vascular dysfunction
-
Radovits T., Seres L., Gero D., Berger I., Szabó C., Karck M., and Szabó G. Single dose treatment with PARP-inhibitor INO-1001 improves aging-associated cardiac and vascular dysfunction. Exp. Gerontol. 42 (2007) 676-685
-
(2007)
Exp. Gerontol.
, vol.42
, pp. 676-685
-
-
Radovits, T.1
Seres, L.2
Gero, D.3
Berger, I.4
Szabó, C.5
Karck, M.6
Szabó, G.7
-
100
-
-
33846250408
-
The peroxynitrite decomposition catalyst FP15 improves ageing-associated cardiac and vascular dysfunction
-
Radovits T., Seres L., Gero D., Lin L.N., Beller C.J., Chen S.H., Zotkina J., Berger I., Groves J.T., Szabó C., and Szabó G. The peroxynitrite decomposition catalyst FP15 improves ageing-associated cardiac and vascular dysfunction. Mech. Ageing Dev. 128 (2007) 173-181
-
(2007)
Mech. Ageing Dev.
, vol.128
, pp. 173-181
-
-
Radovits, T.1
Seres, L.2
Gero, D.3
Lin, L.N.4
Beller, C.J.5
Chen, S.H.6
Zotkina, J.7
Berger, I.8
Groves, J.T.9
Szabó, C.10
Szabó, G.11
-
101
-
-
35248845665
-
Anti-oxidative effect of Klotho on endothelial cells through cAMP activation
-
Rakugi H., Matsukawa N., Ishikawa K., Yang J., Imai M., Ikushima M., Maekawa Y., Kida I., Miyazaki J., and Ogihara T. Anti-oxidative effect of Klotho on endothelial cells through cAMP activation. Endocrine 31 (2007) 82-87
-
(2007)
Endocrine
, vol.31
, pp. 82-87
-
-
Rakugi, H.1
Matsukawa, N.2
Ishikawa, K.3
Yang, J.4
Imai, M.5
Ikushima, M.6
Maekawa, Y.7
Kida, I.8
Miyazaki, J.9
Ogihara, T.10
-
102
-
-
33646238028
-
Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process
-
Razzaque M.S., Sitara D., Taguchi T., St-Arnaud R., and Lanske B. Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process. FASEB J. 20 (2006) 720-722
-
(2006)
FASEB J.
, vol.20
, pp. 720-722
-
-
Razzaque, M.S.1
Sitara, D.2
Taguchi, T.3
St-Arnaud, R.4
Lanske, B.5
-
103
-
-
37849019273
-
Diabetes-induced coronary vascular dysfunction involves increased arginase activity
-
Romero M.J., Platt D.H., Tawfik H.E., Labazi M., El-Remessy A.B., Bartoli M., Caldwell R.B., and Caldwell R.W. Diabetes-induced coronary vascular dysfunction involves increased arginase activity. Circ. Res. 102 (2008) 95-102
-
(2008)
Circ. Res.
, vol.102
, pp. 95-102
-
-
Romero, M.J.1
Platt, D.H.2
Tawfik, H.E.3
Labazi, M.4
El-Remessy, A.B.5
Bartoli, M.6
Caldwell, R.B.7
Caldwell, R.W.8
-
104
-
-
42549088600
-
Endothelial arginase II: a novel target for the treatment of atherosclerosis
-
Ryoo S., Gupta G., Benjo A., Lim H.K., Camara A., Sikka G., Lim H.K., Sohi J., Santhanam L., Soucy K., Tuday E., Baraban E., Ilies M., Gerstenblith G., Nyhan D., Shoukas A., Christianson D.W., Alp N.J., Champion H.C., Huso D., and Berkowitz D.E. Endothelial arginase II: a novel target for the treatment of atherosclerosis. Circ. Res. 102 (2008) 923-932
-
(2008)
Circ. Res.
, vol.102
, pp. 923-932
-
-
Ryoo, S.1
Gupta, G.2
Benjo, A.3
Lim, H.K.4
Camara, A.5
Sikka, G.6
Lim, H.K.7
Sohi, J.8
Santhanam, L.9
Soucy, K.10
Tuday, E.11
Baraban, E.12
Ilies, M.13
Gerstenblith, G.14
Nyhan, D.15
Shoukas, A.16
Christianson, D.W.17
Alp, N.J.18
Champion, H.C.19
Huso, D.20
Berkowitz, D.E.21
more..
-
105
-
-
0034710838
-
In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome
-
Saito Y., Nakamura T., Ohyama Y., Suzuki T., Iida A., Shiraki-Iida T., Kuro-o M., Nabeshima Y., Kurabayashi M., and Nagai R. In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome. Biochem. Biophys. Res. Commun. 276 (2000) 767-772
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.276
, pp. 767-772
-
-
Saito, Y.1
Nakamura, T.2
Ohyama, Y.3
Suzuki, T.4
Iida, A.5
Shiraki-Iida, T.6
Kuro-o, M.7
Nabeshima, Y.8
Kurabayashi, M.9
Nagai, R.10
-
106
-
-
0032551734
-
Klotho protein protects against endothelial dysfunction
-
Saito Y., Yamagishi T., Nakamura T., Ohyama Y., Aizawa H., Suga T., Matsumura Y., Masuda H., Kurabayashi M., Kuro-o M., Nabeshima Y., and Nagai R. Klotho protein protects against endothelial dysfunction. Biochem. Biophys. Res. Commun. 248 (1998) 324-329
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.248
, pp. 324-329
-
-
Saito, Y.1
Yamagishi, T.2
Nakamura, T.3
Ohyama, Y.4
Aizawa, H.5
Suga, T.6
Matsumura, Y.7
Masuda, H.8
Kurabayashi, M.9
Kuro-o, M.10
Nabeshima, Y.11
Nagai, R.12
-
107
-
-
5644235491
-
Forearm endothelial function and bone mineral loss in postmenopausal women
-
Sanada M., Taguchi A., Higashi Y., Tsuda M., Kodama I., Yoshizumi M., and Ohama K. Forearm endothelial function and bone mineral loss in postmenopausal women. Atherosclerosis 176 (2004) 387-392
-
(2004)
Atherosclerosis
, vol.176
, pp. 387-392
-
-
Sanada, M.1
Taguchi, A.2
Higashi, Y.3
Tsuda, M.4
Kodama, I.5
Yoshizumi, M.6
Ohama, K.7
-
109
-
-
34848861137
-
Inducible NO synthase dependent S-nitrosylation and activation of arginase1 contribute to age-related endothelial dysfunction
-
Santhanam L., Lim H.K., Lim H.K., Miriel V., Brown T., Patel M., Balanson S., Ryoo S., Anderson M., Irani K., Khanday F., Di Costanzo L., Nyhan D., Hare J.M., Christianson D.W., Rivers R., Shoukas A., and Berkowitz D.E. Inducible NO synthase dependent S-nitrosylation and activation of arginase1 contribute to age-related endothelial dysfunction. Circ. Res. 101 (2007) 692-702
-
(2007)
Circ. Res.
, vol.101
, pp. 692-702
-
-
Santhanam, L.1
Lim, H.K.2
Lim, H.K.3
Miriel, V.4
Brown, T.5
Patel, M.6
Balanson, S.7
Ryoo, S.8
Anderson, M.9
Irani, K.10
Khanday, F.11
Di Costanzo, L.12
Nyhan, D.13
Hare, J.M.14
Christianson, D.W.15
Rivers, R.16
Shoukas, A.17
Berkowitz, D.E.18
-
110
-
-
0347918852
-
Age-dependent depression in circulating endothelial progenitor cells in patients undergoing coronary artery bypass grafting
-
Scheubel R.J., Zorn H., Silber R.E., Kuss O., Morawietz H., Holtz J., and Simm A. Age-dependent depression in circulating endothelial progenitor cells in patients undergoing coronary artery bypass grafting. J. Am. Coll. Cardiol. 42 (2003) 2073-2080
-
(2003)
J. Am. Coll. Cardiol.
, vol.42
, pp. 2073-2080
-
-
Scheubel, R.J.1
Zorn, H.2
Silber, R.E.3
Kuss, O.4
Morawietz, H.5
Holtz, J.6
Simm, A.7
-
111
-
-
1642388491
-
Telomeres and cardiovascular disease: does size matter?
-
Serrano A.L., and Andrés V. Telomeres and cardiovascular disease: does size matter?. Circ. Res. 94 (2004) 575-584
-
(2004)
Circ. Res.
, vol.94
, pp. 575-584
-
-
Serrano, A.L.1
Andrés, V.2
-
112
-
-
4944242707
-
Angiogenesis and vasculogenesis are impaired in the precocious-aging klotho mouse
-
Shimada T., Takeshita Y., Murohara T., Sasaki K., Egami K., Shintani S., Katsuda Y., Ikeda H., Nabeshima Y., and Imaizumi T. Angiogenesis and vasculogenesis are impaired in the precocious-aging klotho mouse. Circulation 110 (2004) 1148-1155
-
(2004)
Circulation
, vol.110
, pp. 1148-1155
-
-
Shimada, T.1
Takeshita, Y.2
Murohara, T.3
Sasaki, K.4
Egami, K.5
Shintani, S.6
Katsuda, Y.7
Ikeda, H.8
Nabeshima, Y.9
Imaizumi, T.10
-
113
-
-
0025167048
-
Tumor necrosis factor reduces lifespan of human endothelial cells in vitro
-
Shimada Y., Ito H., Kaji K., and Fukuda M. Tumor necrosis factor reduces lifespan of human endothelial cells in vitro. Mech. Ageing Dev. 55 (1990) 245-254
-
(1990)
Mech. Ageing Dev.
, vol.55
, pp. 245-254
-
-
Shimada, Y.1
Ito, H.2
Kaji, K.3
Fukuda, M.4
-
114
-
-
10544239533
-
The importance of the hyperpolarizing mechanism increases as the vessel size decreases in endothelium-dependent relaxations in rat mesenteric circulation
-
Shimokawa H., Yasutake H., Fujii K., Owada M.K., Nakaike R., Fukumoto Y., Takayanagi T., Nagao T., Egashira K., Fujishima M., and Takeshita A. The importance of the hyperpolarizing mechanism increases as the vessel size decreases in endothelium-dependent relaxations in rat mesenteric circulation. J. Cardiovasc. Pharmacol. 28 (1996) 703-711
-
(1996)
J. Cardiovasc. Pharmacol.
, vol.28
, pp. 703-711
-
-
Shimokawa, H.1
Yasutake, H.2
Fujii, K.3
Owada, M.K.4
Nakaike, R.5
Fukumoto, Y.6
Takayanagi, T.7
Nagao, T.8
Egashira, K.9
Fujishima, M.10
Takeshita, A.11
-
115
-
-
77949268099
-
-
Sindler, A.L., Delp, M.D., Reyes, R., Wu, G., Muller-Delp, J.M., in press. Effects of aging and exercise training on eNOS uncoupling in skeletal muscle resistance arterioles. J. Physiol. (available online).
-
Sindler, A.L., Delp, M.D., Reyes, R., Wu, G., Muller-Delp, J.M., in press. Effects of aging and exercise training on eNOS uncoupling in skeletal muscle resistance arterioles. J. Physiol. (available online).
-
-
-
-
116
-
-
33748917958
-
Plasma membrane-associated endothelial nitric oxide synthase and activity in aging rat aortic vascular endothelia markedly decline with age
-
Smith A.R., Visioli F., and Hagen T.M. Plasma membrane-associated endothelial nitric oxide synthase and activity in aging rat aortic vascular endothelia markedly decline with age. Arch. Biochem. Biophys. 454 (2006) 100-105
-
(2006)
Arch. Biochem. Biophys.
, vol.454
, pp. 100-105
-
-
Smith, A.R.1
Visioli, F.2
Hagen, T.M.3
-
117
-
-
33845400838
-
Impaired shear stress-induced nitric oxide production through decreased NOS phosphorylation contributes to age-related vascular stiffness
-
Soucy K.G., Ryoo S., Benjo A., Lim H.K., Gupta G., Sohi J.S., Elser J., Aon M.A., Nyhan D., Shoukas A.A., and Berkowitz D.E. Impaired shear stress-induced nitric oxide production through decreased NOS phosphorylation contributes to age-related vascular stiffness. J. Appl. Physiol. 101 (2006) 1751-1759
-
(2006)
J. Appl. Physiol.
, vol.101
, pp. 1751-1759
-
-
Soucy, K.G.1
Ryoo, S.2
Benjo, A.3
Lim, H.K.4
Gupta, G.5
Sohi, J.S.6
Elser, J.7
Aon, M.A.8
Nyhan, D.9
Shoukas, A.A.10
Berkowitz, D.E.11
-
118
-
-
2442652730
-
Effects of ageing and exercise training on endothelium-dependent vasodilatation and structure of rat skeletal muscle arterioles
-
Spier S.A., Delp M.D., Meininger C.J., Donato A.J., Ramsey M.W., and Muller-Delp J.M. Effects of ageing and exercise training on endothelium-dependent vasodilatation and structure of rat skeletal muscle arterioles. J. Physiol. 556 (2004) 947-958
-
(2004)
J. Physiol.
, vol.556
, pp. 947-958
-
-
Spier, S.A.1
Delp, M.D.2
Meininger, C.J.3
Donato, A.J.4
Ramsey, M.W.5
Muller-Delp, J.M.6
-
120
-
-
33744987670
-
Amelioration of age-related inflammation and oxidative stress by PPARgamma activator: suppression of NF-kappaB by 2,4-thiazolidinedione
-
Sung B., Park S., Yu B.P., and Chung H.Y. Amelioration of age-related inflammation and oxidative stress by PPARgamma activator: suppression of NF-kappaB by 2,4-thiazolidinedione. Exp. Gerontol. 41 (2006) 590-599
-
(2006)
Exp. Gerontol.
, vol.41
, pp. 590-599
-
-
Sung, B.1
Park, S.2
Yu, B.P.3
Chung, H.Y.4
-
121
-
-
40149085142
-
Gene expression changes of prostanoid synthases in endothelial cells and prostanoid receptors in vascular smooth muscle cells caused by aging and hypertension
-
Tang E.H., and Vanhoutte P.M. Gene expression changes of prostanoid synthases in endothelial cells and prostanoid receptors in vascular smooth muscle cells caused by aging and hypertension. Physiol. Genom. 32 (2008) 409-418
-
(2008)
Physiol. Genom.
, vol.32
, pp. 409-418
-
-
Tang, E.H.1
Vanhoutte, P.M.2
-
122
-
-
0037470501
-
The endocrine regulation of aging by insulin-like signals
-
Tatar M., Bartke A., and Antebi A. The endocrine regulation of aging by insulin-like signals. Science 299 (2003) 1346-1351
-
(2003)
Science
, vol.299
, pp. 1346-1351
-
-
Tatar, M.1
Bartke, A.2
Antebi, A.3
-
123
-
-
33847039083
-
Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1
-
Thum T., Hoeber S., Froese S., Klink I., Stichtenoth D.O., Galuppo P., Jakob M., Tsikas D., Anker S.D., Poole-Wilson P.A., Borlak J., Ertl G., and Bauersachs J. Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1. Circ. Res. 100 (2007) 434-443
-
(2007)
Circ. Res.
, vol.100
, pp. 434-443
-
-
Thum, T.1
Hoeber, S.2
Froese, S.3
Klink, I.4
Stichtenoth, D.O.5
Galuppo, P.6
Jakob, M.7
Tsikas, D.8
Anker, S.D.9
Poole-Wilson, P.A.10
Borlak, J.11
Ertl, G.12
Bauersachs, J.13
-
124
-
-
0036461633
-
Aging, ion channel expression, and vascular function
-
Toro L., Marijic J., Nishimaru K., Tanaka Y., Song M., and Stefani E. Aging, ion channel expression, and vascular function. Vascul. Pharmacol. 38 (2002) 73-80
-
(2002)
Vascul. Pharmacol.
, vol.38
, pp. 73-80
-
-
Toro, L.1
Marijic, J.2
Nishimaru, K.3
Tanaka, Y.4
Song, M.5
Stefani, E.6
-
126
-
-
0033732110
-
Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes
-
Toussaint O., Medrano E.E., and von Zglinicki T. Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Exp. Gerontol. 35 (2000) 927-945
-
(2000)
Exp. Gerontol.
, vol.35
, pp. 927-945
-
-
Toussaint, O.1
Medrano, E.E.2
von Zglinicki, T.3
-
127
-
-
3242722213
-
Differential regulation of telomerase in endothelial cells by fibroblast growth factor-2 and vascular endothelial growth factor-a: association with replicative life span
-
Trivier E., Kurz D.J., Hong Y., Huang H.L., and Erusalimsky J.D. Differential regulation of telomerase in endothelial cells by fibroblast growth factor-2 and vascular endothelial growth factor-a: association with replicative life span. Ann. N.Y. Acad. Sci. 1019 (2004) 111-115
-
(2004)
Ann. N.Y. Acad. Sci.
, vol.1019
, pp. 111-115
-
-
Trivier, E.1
Kurz, D.J.2
Hong, Y.3
Huang, H.L.4
Erusalimsky, J.D.5
-
128
-
-
12344251549
-
Vascular inflammation in aging
-
Ungvari Z., Csiszar A., and Kaley G. Vascular inflammation in aging. Herz 29 (2004) 733-740
-
(2004)
Herz
, vol.29
, pp. 733-740
-
-
Ungvari, Z.1
Csiszar, A.2
Kaley, G.3
-
130
-
-
0033812019
-
Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging
-
Utsugi T., Ohno T., Ohyama Y., Uchiyama T., Saito Y., Matsumura Y., Aizawa H., Itoh H., Kurabayashi M., Kawazu S., Tomono S., Oka Y., Suga T., Kuro-o M., Nabeshima Y., and Nagai R. Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging. Metabolism 49 (2000) 1118-1123
-
(2000)
Metabolism
, vol.49
, pp. 1118-1123
-
-
Utsugi, T.1
Ohno, T.2
Ohyama, Y.3
Uchiyama, T.4
Saito, Y.5
Matsumura, Y.6
Aizawa, H.7
Itoh, H.8
Kurabayashi, M.9
Kawazu, S.10
Tomono, S.11
Oka, Y.12
Suga, T.13
Kuro-o, M.14
Nabeshima, Y.15
Nagai, R.16
-
131
-
-
0034684652
-
Enhanced peroxynitrite formation is associated with vascular aging
-
Van der Loo B., Labugger R., Skepper J.N., Bachschmid M., Kilo J., Powell J.M., Palacios-Callender M., Erusalimsky J.D., Quaschning T., Malinski T., Gygi D., Ullrich V., and Lüscher T.F. Enhanced peroxynitrite formation is associated with vascular aging. J. Exp. Med. 192 (2000) 1731-1744
-
(2000)
J. Exp. Med.
, vol.192
, pp. 1731-1744
-
-
Van der Loo, B.1
Labugger, R.2
Skepper, J.N.3
Bachschmid, M.4
Kilo, J.5
Powell, J.M.6
Palacios-Callender, M.7
Erusalimsky, J.D.8
Quaschning, T.9
Malinski, T.10
Gygi, D.11
Ullrich, V.12
Lüscher, T.F.13
-
132
-
-
34547647233
-
Endothelin-1 vasoconstrictor tone increases with age in healthy men but can be reduced by regular aerobic exercise
-
Van Guilder G.P., Westby C.M., Greiner J.J., Stauffer B.L., and De Souza C.A. Endothelin-1 vasoconstrictor tone increases with age in healthy men but can be reduced by regular aerobic exercise. Hypertension 50 (2007) 403-409
-
(2007)
Hypertension
, vol.50
, pp. 403-409
-
-
Van Guilder, G.P.1
Westby, C.M.2
Greiner, J.J.3
Stauffer, B.L.4
De Souza, C.A.5
-
133
-
-
65649110801
-
Endothelial dysfunction
-
Vanhoutte P.M. Endothelial dysfunction. Circ. J. 73 (2009) 595-601
-
(2009)
Circ. J.
, vol.73
, pp. 595-601
-
-
Vanhoutte, P.M.1
-
134
-
-
56649094583
-
Endothelium-dependent contractions: when a good guy turns bad
-
Vanhoutte P.M., and Tang E.H.C. Endothelium-dependent contractions: when a good guy turns bad. J. Physiol. 586 (2008) 5295-5304
-
(2008)
J. Physiol.
, vol.586
, pp. 5295-5304
-
-
Vanhoutte, P.M.1
Tang, E.H.C.2
-
135
-
-
0034730782
-
Nitric oxide activates telomerase and delays endothelial cell senescence
-
Vasa M., Breitschopf K., Zeiher A.M., and Dimmeler S. Nitric oxide activates telomerase and delays endothelial cell senescence. Circ. Res. 87 (2000) 540-542
-
(2000)
Circ. Res.
, vol.87
, pp. 540-542
-
-
Vasa, M.1
Breitschopf, K.2
Zeiher, A.M.3
Dimmeler, S.4
-
136
-
-
0037305699
-
The role of tetrahydrobiopterin in superoxide generation from eNOS: enzymology and physiological implications
-
Vásquez-Vivar J., Kalyanaraman B., and Martásek P. The role of tetrahydrobiopterin in superoxide generation from eNOS: enzymology and physiological implications. Free Radic. Res. 37 (2003) 121-127
-
(2003)
Free Radic. Res.
, vol.37
, pp. 121-127
-
-
Vásquez-Vivar, J.1
Kalyanaraman, B.2
Martásek, P.3
-
137
-
-
34250819965
-
Isolated systolic hypertension is characterized by increased aortic stiffness and endothelial dysfunction
-
Wallace S.M., Yasmin, McEniery C.M., Mäki-Petäjä K.M., Booth A.D., Cockcroft J.R., and Wilkinson I.B. Isolated systolic hypertension is characterized by increased aortic stiffness and endothelial dysfunction. Hypertension 50 (2007) 228-233
-
(2007)
Hypertension
, vol.50
, pp. 228-233
-
-
Wallace, S.M.1
Yasmin2
McEniery, C.M.3
Mäki-Petäjä, K.M.4
Booth, A.D.5
Cockcroft, J.R.6
Wilkinson, I.B.7
-
138
-
-
57749190558
-
Current understanding of klotho
-
Wang Y., and Sun Z. Current understanding of klotho. Ageing Res. Rev. 8 (2009) 43-51
-
(2009)
Ageing Res. Rev.
, vol.8
, pp. 43-51
-
-
Wang, Y.1
Sun, Z.2
-
139
-
-
0034754033
-
Aging-associated changes in vascular activity: a potential link to geriatric cardiovascular disease
-
Weinsaft J.W., and Edelberg J.M. Aging-associated changes in vascular activity: a potential link to geriatric cardiovascular disease. Am. J. Geriatr. Cardiol. 10 (2001) 348-354
-
(2001)
Am. J. Geriatr. Cardiol.
, vol.10
, pp. 348-354
-
-
Weinsaft, J.W.1
Edelberg, J.M.2
-
140
-
-
31944447852
-
Knockdown of arginase I restores NO signaling in the vasculature of old rats
-
White A.R., Ryoo S., Li D., Champion H.C., Steppan J., Wang D., Nyhan D., Shoukas A.A., Hare J.M., and Berkowitz D.E. Knockdown of arginase I restores NO signaling in the vasculature of old rats. Hypertension 47 (2006) 245-251
-
(2006)
Hypertension
, vol.47
, pp. 245-251
-
-
White, A.R.1
Ryoo, S.2
Li, D.3
Champion, H.C.4
Steppan, J.5
Wang, D.6
Nyhan, D.7
Shoukas, A.A.8
Hare, J.M.9
Berkowitz, D.E.10
-
141
-
-
34250667042
-
Research on the age-related changes in the nitric oxide pathway in the arteries of rats and the intervention effect of dehydroepiandrosterone
-
Wu S., Ruan Y., Yin M., and Lai W. Research on the age-related changes in the nitric oxide pathway in the arteries of rats and the intervention effect of dehydroepiandrosterone. Gerontology 53 (2007) 234-237
-
(2007)
Gerontology
, vol.53
, pp. 234-237
-
-
Wu, S.1
Ruan, Y.2
Yin, M.3
Lai, W.4
-
142
-
-
0029900905
-
Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury
-
Xia Y., Dawson V.L., Dawson T.M., Snyder S.H., and Zweier J.L. Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 6770-6774
-
(1996)
Proc. Natl. Acad. Sci. U.S.A.
, vol.93
, pp. 6770-6774
-
-
Xia, Y.1
Dawson, V.L.2
Dawson, T.M.3
Snyder, S.H.4
Zweier, J.L.5
-
143
-
-
0031002421
-
Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages
-
Xia Y., and Zweier J.L. Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 6954-6958
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 6954-6958
-
-
Xia, Y.1
Zweier, J.L.2
-
144
-
-
0141763944
-
Senescence-enhanced oxidative stress is associated with deficiency of mitochondrial cytochrome c oxidase in vascular endothelial cells
-
Xin M.G., Zhang J., Block E.R., and Patel J.M. Senescence-enhanced oxidative stress is associated with deficiency of mitochondrial cytochrome c oxidase in vascular endothelial cells. Mech. Ageing Dev. 124 (2003) 911-919
-
(2003)
Mech. Ageing Dev.
, vol.124
, pp. 911-919
-
-
Xin, M.G.1
Zhang, J.2
Block, E.R.3
Patel, J.M.4
-
145
-
-
0034779222
-
Elevated serum endogenous inhibitor of nitric oxide synthase and endothelial dysfunction in aged rats
-
Xiong Y., Yuan L.W., Deng H.W., Li Y.J., and Chen B.M. Elevated serum endogenous inhibitor of nitric oxide synthase and endothelial dysfunction in aged rats. Clin. Exp. Pharmacol. Physiol. 28 (2001) 842-847
-
(2001)
Clin. Exp. Pharmacol. Physiol.
, vol.28
, pp. 842-847
-
-
Xiong, Y.1
Yuan, L.W.2
Deng, H.W.3
Li, Y.J.4
Chen, B.M.5
-
146
-
-
0033543760
-
Human endothelial cell life extension by telomerase expression
-
Yang J., Chang E., Cherry A.M., Bangs C.D., Oei Y., Bodnar A., Bronstein A., Chiu C.P., and Herron G.S. Human endothelial cell life extension by telomerase expression. J. Biol. Chem. 274 (1999) 26141-26148
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 26141-26148
-
-
Yang, J.1
Chang, E.2
Cherry, A.M.3
Bangs, C.D.4
Oei, Y.5
Bodnar, A.6
Bronstein, A.7
Chiu, C.P.8
Herron, G.S.9
-
147
-
-
34249723602
-
Vascular smooth muscle and endothelial functions in aging
-
Yildiz O. Vascular smooth muscle and endothelial functions in aging. Ann. N.Y. Acad. Sci. 1100 (2007) 353-360
-
(2007)
Ann. N.Y. Acad. Sci.
, vol.1100
, pp. 353-360
-
-
Yildiz, O.1
-
148
-
-
0033839281
-
Alterations of tetrahydrobiopterin biosynthesis and pteridine levels in mouse tissues during growth and aging
-
Yoshida Y.I., Eda S., and Masada M. Alterations of tetrahydrobiopterin biosynthesis and pteridine levels in mouse tissues during growth and aging. Brain Dev. 22 Suppl. 1 (2000) S45-S49
-
(2000)
Brain Dev.
, vol.22
, Issue.SUPPL. 1
-
-
Yoshida, Y.I.1
Eda, S.2
Masada, M.3
-
149
-
-
20244373955
-
Telomerase mediates vascular endothelial growth factor-dependent responsiveness in a rat model of hind limb ischemia
-
Zaccagnini G., Gaetano C., Della Pietra L., Nanni S., Grasselli A., Mangoni A., Benvenuto R., Fabrizi M., Truffa S., Germani A., Moretti F., Pontecorvi A., Sacchi A., Bacchetti S., Capogrossi M.C., and Farsetti A. Telomerase mediates vascular endothelial growth factor-dependent responsiveness in a rat model of hind limb ischemia. J. Biol. Chem. 280 (2005) 14790-14798
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 14790-14798
-
-
Zaccagnini, G.1
Gaetano, C.2
Della Pietra, L.3
Nanni, S.4
Grasselli, A.5
Mangoni, A.6
Benvenuto, R.7
Fabrizi, M.8
Truffa, S.9
Germani, A.10
Moretti, F.11
Pontecorvi, A.12
Sacchi, A.13
Bacchetti, S.14
Capogrossi, M.C.15
Farsetti, A.16
-
150
-
-
60549098432
-
Role of TNF-α in vascular dysfunction
-
Zhang H., Park Y., Wu J., Chen X., Lee S., Yang J., Dellsperger K.C., and Zhang C. Role of TNF-α in vascular dysfunction. Clin. Sci. 116 (2009) 219-230
-
(2009)
Clin. Sci.
, vol.116
, pp. 219-230
-
-
Zhang, H.1
Park, Y.2
Wu, J.3
Chen, X.4
Lee, S.5
Yang, J.6
Dellsperger, K.C.7
Zhang, C.8
|