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Volumn 9, Issue 10, 2008, Pages 1095-1102

The anti-aging, metabolism potential of SIRT1

Author keywords

Longevity; Metabolism; Mitochondria; Oxidation; SIRT1

Indexed keywords

AGENTS AFFECTING METABOLISM; NICOTINAMIDE ADENINE DINUCLEOTIDE; RESVERATROL; SIRTUIN 1; SMALL MOLECULE ACTIVATOR OF SIRT1; UNCLASSIFIED DRUG;

EID: 53049092131     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (47)

References (69)
  • 1
    • 0033214237 scopus 로고    scopus 로고
    • The Sir2/3/4 complex and Sir2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
    • Kaeberlein M, McVey M, Guarente L: The Sir2/3/4 complex and Sir2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev (1999) 13(19):2570-2580.
    • (1999) Genes Dev , vol.13 , Issue.19 , pp. 2570-2580
    • Kaeberlein, M.1    McVey, M.2    Guarente, L.3
  • 2
    • 0035826271 scopus 로고    scopus 로고
    • Increased dosage of a Sir-2 gene extends lifespan in Caenorhabditis elegans
    • Tissenbaum HA, Guarente L: Increased dosage of a Sir-2 gene extends lifespan in Caenorhabditis elegans. Nature (2001) 410(6825):227-230.
    • (2001) Nature , vol.410 , Issue.6825 , pp. 227-230
    • Tissenbaum, H.A.1    Guarente, L.2
  • 3
    • 33746245679 scopus 로고    scopus 로고
    • C elegans 14-3-3 proteins regulate life span and interact with Sir-2.1 and DAF-16/FOXO
    • Wang Y, Oh SW, Deplancke B, Luo J, Walhout AJ, Tissenbaum HA: C elegans 14-3-3 proteins regulate life span and interact with Sir-2.1 and DAF-16/FOXO. Mech Ageing Dev (2006) 127(9):741-747.
    • (2006) Mech Ageing Dev , vol.127 , Issue.9 , pp. 741-747
    • Wang, Y.1    Oh, S.W.2    Deplancke, B.3    Luo, J.4    Walhout, A.J.5    Tissenbaum, H.A.6
  • 4
    • 0034703217 scopus 로고    scopus 로고
    • Requirement of NAD and Sir2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
    • Lin SJ, Defossez PA, Guarente L: Requirement of NAD and Sir2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science (2000) 289(5487):2126-2128.
    • (2000) Science , vol.289 , Issue.5487 , pp. 2126-2128
    • Lin, S.J.1    Defossez, P.A.2    Guarente, L.3
  • 5
    • 0347128279 scopus 로고    scopus 로고
    • Calorie restriction extends yeast life span by lowering the level of NADH
    • Lin SJ, Ford E, Haigis M, Liszt G, Guarente L: Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev (2004) 18(1):12-16.
    • (2004) Genes Dev , vol.18 , Issue.1 , pp. 12-16
    • Lin, S.J.1    Ford, E.2    Haigis, M.3    Liszt, G.4    Guarente, L.5
  • 6
    • 3943054839 scopus 로고    scopus 로고
    • The Sir2 family of protein deacetylases
    • Blander G, Guarente L: The Sir2 family of protein deacetylases. Annu Rev Biochem (2004) 73:417-435.
    • (2004) Annu Rev Biochem , vol.73 , pp. 417-435
    • Blander, G.1    Guarente, L.2
  • 7
    • 0037221445 scopus 로고    scopus 로고
    • +-dependent deacetylases
    • +-dependent deacetylases. Trends Biochem Sci (2003) 28(1):41-48.
    • (2003) Trends Biochem Sci , vol.28 , Issue.1 , pp. 41-48
    • Denu, J.M.1
  • 8
    • 30044440497 scopus 로고    scopus 로고
    • Sirt1: A metabolic master switch that modulates lifespan
    • Leibiger IB, Berggren PO: Sirt1: A metabolic master switch that modulates lifespan. Nat Med (2006) 12(1):34-36.
    • (2006) Nat Med , vol.12 , Issue.1 , pp. 34-36
    • Leibiger, I.B.1    Berggren, P.O.2
  • 9
    • 10944270187 scopus 로고    scopus 로고
    • The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells
    • Revollo JR, Grimm AA, Imai S: The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells. J Biol Chem (2004) 279(49):50754-50763.
    • (2004) J Biol Chem , vol.279 , Issue.49 , pp. 50754-50763
    • Revollo, J.R.1    Grimm, A.A.2    Imai, S.3
  • 10
    • 8644224064 scopus 로고    scopus 로고
    • Sir2 mediates longevity in the fly through a pathway related to calorie restriction
    • Rogina B, Helfand SL: Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci (2004) 101(45):15998-16003.
    • (2004) Proc Natl Acad Sci , vol.101 , Issue.45 , pp. 15998-16003
    • Rogina, B.1    Helfand, S.L.2
  • 12
    • 14544282413 scopus 로고    scopus 로고
    • Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
    • Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P: Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1. Nature (2005) 434(7029):113-118.
    • (2005) Nature , vol.434 , Issue.7029 , pp. 113-118
    • Rodgers, J.T.1    Lerin, C.2    Haas, W.3    Gygi, S.P.4    Spiegelman, B.M.5    Puigserver, P.6
  • 14
    • 10844236451 scopus 로고    scopus 로고
    • Nutrient availability regulates SIRT1 through a forkhead-dependent pathway
    • Nemoto S, Fergusson MM, Finkel T: Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. Science (2004) 306(5704):2105-2108.
    • (2004) Science , vol.306 , Issue.5704 , pp. 2105-2108
    • Nemoto, S.1    Fergusson, M.M.2    Finkel, T.3
  • 15
    • 46249100836 scopus 로고    scopus 로고
    • Tissue-specific regulation of SIRT1 by calorie restriction
    • The tissue-specific impact of SIRT1 function in animals (mouse) was demonstrated for the first time. This is highly relevant for the therapeutic use of SIRT1 modulators. The results suggest that non-tissue-specific targeting of SIRT1 modulators can cause severe side effects, ••
    • Chen D, Bruno J, Easlon E, Lin SJ, Cheng HL, Alt FW, Guarente L: Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev (2008) 22(13):1753-1757. •• The tissue-specific impact of SIRT1 function in animals (mouse) was demonstrated for the first time. This is highly relevant for the therapeutic use of SIRT1 modulators. The results suggest that non-tissue-specific targeting of SIRT1 modulators can cause severe side effects.
    • (2008) Genes Dev , vol.22 , Issue.13 , pp. 1753-1757
    • Chen, D.1    Bruno, J.2    Easlon, E.3    Lin, S.J.4    Cheng, H.L.5    Alt, F.W.6    Guarente, L.7
  • 17
    • 41649102028 scopus 로고    scopus 로고
    • Ambient glucose levels qualify the potency of insulin myogenic actions by regulating SIRT1 and FoxO3a in C2C12 myocytes
    • Nedachi T, Kadotani A, Ariga M, Katagiri H, Kanzaki M: Ambient glucose levels qualify the potency of insulin myogenic actions by regulating SIRT1 and FoxO3a in C2C12 myocytes. Am J Physiol Endocrinol Metab (2008) 294(4):E668-E678.
    • (2008) Am J Physiol Endocrinol Metab , vol.294 , Issue.4
    • Nedachi, T.1    Kadotani, A.2    Ariga, M.3    Katagiri, H.4    Kanzaki, M.5
  • 21
    • 34547906123 scopus 로고    scopus 로고
    • Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1
    • The central role of SIRT1 in glucose, fat and cholesterol metabolism was demonstrated in animals, •
    • Rodgers JT, Puigserver P: Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. Proc Natl Acad Sci (2007) 104(31):12861-12866. • The central role of SIRT1 in glucose, fat and cholesterol metabolism was demonstrated in animals.
    • (2007) Proc Natl Acad Sci , vol.104 , Issue.31 , pp. 12861-12866
    • Rodgers, J.T.1    Puigserver, P.2
  • 22
    • 20144365700 scopus 로고    scopus 로고
    • Nuclear trapping of the forkhead transcription factor FoxO1 via SIRT-dependent deacetylation promotes expression of glucogenetic genes
    • Frescas D, Valenti L, Accili D: Nuclear trapping of the forkhead transcription factor FoxO1 via SIRT-dependent deacetylation promotes expression of glucogenetic genes. J Biol Chem (2005) 280(21):20589-20595.
    • (2005) J Biol Chem , vol.280 , Issue.21 , pp. 20589-20595
    • Frescas, D.1    Valenti, L.2    Accili, D.3
  • 24
    • 0034650763 scopus 로고    scopus 로고
    • The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP
    • Ricquier D, Bouillaud F: The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. Biochem J (2000) 345:161-179.
    • (2000) Biochem J , vol.345 , pp. 161-179
    • Ricquier, D.1    Bouillaud, F.2
  • 29
    • 0035857020 scopus 로고    scopus 로고
    • New drug targets for type 2 diabetes and the metabolic syndrome
    • Moller DE: New drug targets for type 2 diabetes and the metabolic syndrome. Nature (2001) 414(6865):821-827.
    • (2001) Nature , vol.414 , Issue.6865 , pp. 821-827
    • Moller, D.E.1
  • 30
    • 34548857700 scopus 로고    scopus 로고
    • SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B
    • Sun C, Zhang F, Ge X, Yan T, Chen X, Shi X, Zhai Q: SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell Metab (2007) 6(4):307-319.
    • (2007) Cell Metab , vol.6 , Issue.4 , pp. 307-319
    • Sun, C.1    Zhang, F.2    Ge, X.3    Yan, T.4    Chen, X.5    Shi, X.6    Zhai, Q.7
  • 32
    • 37349110355 scopus 로고    scopus 로고
    • Metabolic adaptations through the PGC-1 α and SIRT1 pathways
    • Rodgers JT, Lerin C, Gerhart-Hines Z, Puigserver P: Metabolic adaptations through the PGC-1 α and SIRT1 pathways. FEBS Lett (2008) 582(1):46-53.
    • (2008) FEBS Lett , vol.582 , Issue.1 , pp. 46-53
    • Rodgers, J.T.1    Lerin, C.2    Gerhart-Hines, Z.3    Puigserver, P.4
  • 34
    • 22744444561 scopus 로고    scopus 로고
    • Calorie restriction and SIR2 genes - towards a mechanism
    • Guarente L: Calorie restriction and SIR2 genes - towards a mechanism. Mech Ageing Dev (2005) 126(9):923-928.
    • (2005) Mech Ageing Dev , vol.126 , Issue.9 , pp. 923-928
    • Guarente, L.1
  • 35
    • 33845985335 scopus 로고    scopus 로고
    • SIRT1 regulates adiponectin gene expression through FoxO1-C/enhancer-binding protein α transcriptional complex
    • Qiao L, Shao J: SIRT1 regulates adiponectin gene expression through FoxO1-C/enhancer-binding protein α transcriptional complex. J Biol Chem (2006) 281(52):39915-39924.
    • (2006) J Biol Chem , vol.281 , Issue.52 , pp. 39915-39924
    • Qiao, L.1    Shao, J.2
  • 36
    • 0034881391 scopus 로고    scopus 로고
    • The adipocyte-secreted protein ACRP30 enhances hepatic insulin action
    • Berg AH, Combs TP, Du X, Brownlee M, Scherer PE: The adipocyte-secreted protein ACRP30 enhances hepatic insulin action. Nat Med (2001) 7(8):947-953.
    • (2001) Nat Med , vol.7 , Issue.8 , pp. 947-953
    • Berg, A.H.1    Combs, T.P.2    Du, X.3    Brownlee, M.4    Scherer, P.E.5
  • 39
    • 18844432308 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors
    • Kadowaki T, Yamauchi T: Adiponectin and adiponectin receptors. Endocr Rev (2005) 26(3):439-451.
    • (2005) Endocr Rev , vol.26 , Issue.3 , pp. 439-451
    • Kadowaki, T.1    Yamauchi, T.2
  • 41
    • 42449100009 scopus 로고    scopus 로고
    • Isoflavones promote mitochondrial biogenesis
    • Rasbach KA, Schnellmann RG: Isoflavones promote mitochondrial biogenesis. J Pharmacol Exp Ther (2008) 325(2): 536-543.
    • (2008) J Pharmacol Exp Ther , vol.325 , Issue.2 , pp. 536-543
    • Rasbach, K.A.1    Schnellmann, R.G.2
  • 44
    • 45549098657 scopus 로고    scopus 로고
    • Boily G, Seifert EL, Bevilacqua L, He XH, Sabourin G, Estey C, Moffat C, Crawford S, Saliba S, Jardine K, Xuan J et al: SIRT1 regulates energy metabolism and response to caloric restriction in mice. PLoS ONE (2008) 3(3):e1759. •• The importance of SIRT1 in response to CR in mammals was demonstrated by using SIRT1 null mice. The study also examined several direct and relevant parameters of energy balance, such as hyperphagia, metabolic rate and substrate utilization, respiration rate, and overall hormone profile.
    • Boily G, Seifert EL, Bevilacqua L, He XH, Sabourin G, Estey C, Moffat C, Crawford S, Saliba S, Jardine K, Xuan J et al: SIRT1 regulates energy metabolism and response to caloric restriction in mice. PLoS ONE (2008) 3(3):e1759. •• The importance of SIRT1 in response to CR in mammals was demonstrated by using SIRT1 null mice. The study also examined several direct and relevant parameters of energy balance, such as hyperphagia, metabolic rate and substrate utilization, respiration rate, and overall hormone profile.
  • 45
    • 21844467979 scopus 로고    scopus 로고
    • New insights into the regulation of HDL metabolism and reverse cholesterol transport
    • Lewis GF, Rader DJ: New insights into the regulation of HDL metabolism and reverse cholesterol transport. Circ Res (2005) 96(12):1221-1232.
    • (2005) Circ Res , vol.96 , Issue.12 , pp. 1221-1232
    • Lewis, G.F.1    Rader, D.J.2
  • 46
    • 34948883324 scopus 로고    scopus 로고
    • SIRT1 deacetylates and positively regulates the nuclear receptor LXR
    • An important transcriptional regulator of cholesterol metabolism was identified, thereby providing insight into SIRT1's regulation of cholesterol metabolism for the first time, •
    • Li X, Zhang S, Blander G, Tse JG, Krieger M, Guarente L: SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol Cell (2007) 28(1):91-106. • An important transcriptional regulator of cholesterol metabolism was identified, thereby providing insight into SIRT1's regulation of cholesterol metabolism for the first time.
    • (2007) Mol Cell , vol.28 , Issue.1 , pp. 91-106
    • Li, X.1    Zhang, S.2    Blander, G.3    Tse, J.G.4    Krieger, M.5    Guarente, L.6
  • 47
    • 2342647592 scopus 로고    scopus 로고
    • Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans
    • Fontana L, Meyer TE, Klein S, Holloszy JO: Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans. Proc Natl Acad Sci USA (2004) 101(17):6659-6663.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.17 , pp. 6659-6663
    • Fontana, L.1    Meyer, T.E.2    Klein, S.3    Holloszy, J.O.4
  • 48
    • 40449093056 scopus 로고    scopus 로고
    • Mammalian sirtuin 1 is involved in the protective action of dietary saturated fat against alcoholic fatty liver in mice
    • It was demonstrated that ethanol can alter SIRT1 activity, thus providing insight into SIRT1's potentially protective role in chronic liver steatosis, •
    • You M, Cao Q, Liang X, Ajmo JM, Ness GC: Mammalian sirtuin 1 is involved in the protective action of dietary saturated fat against alcoholic fatty liver in mice. J Nutr (2008) 138(3): 497-501. • It was demonstrated that ethanol can alter SIRT1 activity, thus providing insight into SIRT1's potentially protective role in chronic liver steatosis.
    • (2008) J Nutr , vol.138 , Issue.3 , pp. 497-501
    • You, M.1    Cao, Q.2    Liang, X.3    Ajmo, J.M.4    Ness, G.C.5
  • 49
    • 0035826271 scopus 로고    scopus 로고
    • Increased dosage of a Sir-2 gene extends lifespan in Caenorhabditis elegans
    • Tissenbaum HA, Guarente L: Increased dosage of a Sir-2 gene extends lifespan in Caenorhabditis elegans. Nature (2001) 410(6825):227-230.
    • (2001) Nature , vol.410 , Issue.6825 , pp. 227-230
    • Tissenbaum, H.A.1    Guarente, L.2
  • 50
    • 33846423520 scopus 로고    scopus 로고
    • Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
    • Hansen M, Taubert S, Crawford D, Libina N, Lee SJ, Kenyon C: Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell (2007) 6(1):95-110.
    • (2007) Aging Cell , vol.6 , Issue.1 , pp. 95-110
    • Hansen, M.1    Taubert, S.2    Crawford, D.3    Libina, N.4    Lee, S.J.5    Kenyon, C.6
  • 51
    • 19344374925 scopus 로고    scopus 로고
    • Sir2-independent life span extension by calorie restriction in yeast
    • Kaeberlein M, Kirkland KT, Fields S, Kennedy BK: Sir2-independent life span extension by calorie restriction in yeast. PLoS Biol (2004) 2(9):E296.
    • (2004) PLoS Biol , vol.2 , Issue.9
    • Kaeberlein, M.1    Kirkland, K.T.2    Fields, S.3    Kennedy, B.K.4
  • 54
    • 45549096918 scopus 로고    scopus 로고
    • SIRT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons
    • The anti- or pro-survival role for SIRT1, depending on dietary conditions and signaling through the ERK1/2, was demonstrated in the mouse, •
    • Li Y, Xu W, McBurney MW, Longo VD: SIRT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab (2008) 8(1):38-48. • The anti- or pro-survival role for SIRT1, depending on dietary conditions and signaling through the ERK1/2, was demonstrated in the mouse.
    • (2008) Cell Metab , vol.8 , Issue.1 , pp. 38-48
    • Li, Y.1    Xu, W.2    McBurney, M.W.3    Longo, V.D.4
  • 56
    • 38349112898 scopus 로고    scopus 로고
    • Age-associated loss of SIRT1-mediated enhancement of glucose-stimulated insulin secretion in β cell-specific SIRT1-overexpressing (BESTO) mice
    • The activity of SIRT1 diminishes with advancing age. This is highly relevant for SIRT1's role in age-related diseases, and the complex nature of its regulation of a number of cellular processes, ••
    • Ramsey KM, Mills KF, Satoh A, Imai S: Age-associated loss of SIRT1-mediated enhancement of glucose-stimulated insulin secretion in β cell-specific SIRT1-overexpressing (BESTO) mice. Aging Cell (2008) 7(1):78-88. •• The activity of SIRT1 diminishes with advancing age. This is highly relevant for SIRT1's role in age-related diseases, and the complex nature of its regulation of a number of cellular processes.
    • (2008) Aging Cell , vol.7 , Issue.1 , pp. 78-88
    • Ramsey, K.M.1    Mills, K.F.2    Satoh, A.3    Imai, S.4
  • 59
    • 3943071801 scopus 로고    scopus 로고
    • Sirtuin activators mimic caloric restriction and delay aging in metazoans
    • Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, Sinclair D: Sirtuin activators mimic caloric restriction and delay aging in metazoans. Nature (2004) 430(7000):686-689.
    • (2004) Nature , vol.430 , Issue.7000 , pp. 686-689
    • Wood, J.G.1    Rogina, B.2    Lavu, S.3    Howitz, K.4    Helfand, S.L.5    Tatar, M.6    Sinclair, D.7
  • 60
    • 33746862126 scopus 로고    scopus 로고
    • Resveratrol inhibits insulin responses in a SIRT1-independent pathway
    • Zhang J: Resveratrol inhibits insulin responses in a SIRT1-independent pathway. Biochem J (2006) 397(3):519-527.
    • (2006) Biochem J , vol.397 , Issue.3 , pp. 519-527
    • Zhang, J.1
  • 61
    • 34249846128 scopus 로고    scopus 로고
    • Resveratrol stimulates AMP kinase activity in neurons
    • Dasgupta B, Milbrandt J: Resveratrol stimulates AMP kinase activity in neurons. Proc Natl Acad Sci (2007) 104(17): 7217-7222.
    • (2007) Proc Natl Acad Sci , vol.104 , Issue.17 , pp. 7217-7222
    • Dasgupta, B.1    Milbrandt, J.2
  • 63
    • 41549134383 scopus 로고    scopus 로고
    • Activation of SIRT1, a class III histone deacetylase, contributes to fructose feeding-mediated induction of the α-myosin heavy chain expression
    • Pillai JB, Chen M, Rajamohan SB, Samant S, Pillai VB, Gupta M, Gupta MP: Activation of SIRT1, a class III histone deacetylase, contributes to fructose feeding-mediated induction of the α-myosin heavy chain expression. Am J Physiol Heart Circ Physiol (2008) 294(3):H1388-H1397.
    • (2008) Am J Physiol Heart Circ Physiol , vol.294 , Issue.3
    • Pillai, J.B.1    Chen, M.2    Rajamohan, S.B.3    Samant, S.4    Pillai, V.B.5    Gupta, M.6    Gupta, M.P.7
  • 64
    • 33947127395 scopus 로고    scopus 로고
    • Resveratrol ameliorates experimental autoimmune myocarditis
    • Yoshida Y, Shioi T, Izumi T: Resveratrol ameliorates experimental autoimmune myocarditis. Circ J (2007) 71(3): 397-404.
    • (2007) Circ J , vol.71 , Issue.3 , pp. 397-404
    • Yoshida, Y.1    Shioi, T.2    Izumi, T.3
  • 67
    • 42449142360 scopus 로고    scopus 로고
    • Interaction of aging-associated signaling cascades: Inhibition of NFκB signaling by longevity factors FoxOs and SIRT1
    • Salminen A, Ojala J, Huuskonen J, Kauppinen A, Suuronen T, Kaarniranta K: Interaction of aging-associated signaling cascades: Inhibition of NFκB signaling by longevity factors FoxOs and SIRT1. Cell Mol Life Sci (2008) 65(7-8):1049-1058.
    • (2008) Cell Mol Life Sci , vol.65 , Issue.7-8 , pp. 1049-1058
    • Salminen, A.1    Ojala, J.2    Huuskonen, J.3    Kauppinen, A.4    Suuronen, T.5    Kaarniranta, K.6
  • 69
    • 0037474507 scopus 로고    scopus 로고
    • Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression
    • Takata T, Ishikawa F: Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression. Biochem Biophys Res Commun (2003) 301(1):250-257.
    • (2003) Biochem Biophys Res Commun , vol.301 , Issue.1 , pp. 250-257
    • Takata, T.1    Ishikawa, F.2


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