-
1
-
-
33947369500
-
G protein-coupled receptor dimerisation: Molecular basis and relevance to function
-
Milligan, G. G protein-coupled receptor dimerisation: molecular basis and relevance to function Biochim. Biophys. Acta 2007, 1768, 825-835
-
(2007)
Biochim. Biophys. Acta
, vol.1768
, pp. 825-835
-
-
Milligan, G.1
-
2
-
-
0035318509
-
Oligomerization of G-protein-coupled transmitter receptors
-
Bouvier, M. Oligomerization of G-protein-coupled transmitter receptors Nat. Rev. Neurosci. 2001, 2, 274-286
-
(2001)
Nat. Rev. Neurosci.
, vol.2
, pp. 274-286
-
-
Bouvier, M.1
-
3
-
-
0035478438
-
Heterodimerization of G-protein-coupled receptors: Pharmacology, signaling and trafficking
-
Devi, L. A. Heterodimerization of G-protein-coupled receptors: pharmacology, signaling and trafficking Trends Pharmacol. Sci. 2001, 22, 532-537
-
(2001)
Trends Pharmacol. Sci.
, vol.22
, pp. 532-537
-
-
Devi, L.A.1
-
4
-
-
0036780743
-
G-protein-coupled receptor oligomerization and its potential for drug discovery
-
George, S. R.; O'Dowd, B. F.; Lee, S. R. G-protein-coupled receptor oligomerization and its potential for drug discovery Nat. Rev. Drug Discovery 2002, 1, 808-820
-
(2002)
Nat. Rev. Drug Discovery
, vol.1
, pp. 808-820
-
-
George, S.R.1
O'Dowd, B.F.2
Lee, S.R.3
-
5
-
-
3042663287
-
G protein-coupled receptor dimerization: Function and ligand pharmacology
-
Milligan, G. G protein-coupled receptor dimerization: function and ligand pharmacology Mol. Pharmacol. 2004, 66, 1-7
-
(2004)
Mol. Pharmacol.
, vol.66
, pp. 1-7
-
-
Milligan, G.1
-
6
-
-
34548530597
-
Functional relevance of neurotransmitter receptor heteromers in the central nervous system
-
Ferre, S.; Ciruela, F.; Woods, A. S.; Lluis, C.; Franco, R. Functional relevance of neurotransmitter receptor heteromers in the central nervous system Trends Neurosci. 2007, 30, 440-446
-
(2007)
Trends Neurosci.
, vol.30
, pp. 440-446
-
-
Ferre, S.1
Ciruela, F.2
Woods, A.S.3
Lluis, C.4
Franco, R.5
-
7
-
-
40349085622
-
A day in the life of a G protein-coupled receptor: The contribution to function of G protein-coupled receptor dimerization
-
Milligan, G. A day in the life of a G protein-coupled receptor: the contribution to function of G protein-coupled receptor dimerization Br. J. Pharmacol. 2008, 153, 216-229
-
(2008)
Br. J. Pharmacol.
, vol.153
, pp. 216-229
-
-
Milligan, G.1
-
8
-
-
80052027428
-
Asymmetry of GPCR oligomers supports their functional relevance
-
Maurice, P.; Kamal, M.; Jockers, R. Asymmetry of GPCR oligomers supports their functional relevance Trends Pharmacol. Sci. 2011, 32, 514-520
-
(2011)
Trends Pharmacol. Sci.
, vol.32
, pp. 514-520
-
-
Maurice, P.1
Kamal, M.2
Jockers, R.3
-
9
-
-
23944501304
-
Heterodimerization of G protein-coupled receptors: Specificity and functional significance
-
Prinster, S. C.; Hague, C.; Hall, R. A. Heterodimerization of G protein-coupled receptors: specificity and functional significance Pharmacol. Rev. 2005, 57, 289-298
-
(2005)
Pharmacol. Rev.
, vol.57
, pp. 289-298
-
-
Prinster, S.C.1
Hague, C.2
Hall, R.A.3
-
10
-
-
0042467972
-
Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons
-
Agnati, L. F.; Ferre, S.; Lluis, C.; Franco, R.; Fuxe, K. Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons Pharmacol. Rev. 2003, 55, 509-550
-
(2003)
Pharmacol. Rev.
, vol.55
, pp. 509-550
-
-
Agnati, L.F.1
Ferre, S.2
Lluis, C.3
Franco, R.4
Fuxe, K.5
-
11
-
-
0029666267
-
2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation
-
2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation J. Biol. Chem. 1996, 271, 16384-16392
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 16384-16392
-
-
Hebert, T.E.1
Moffett, S.2
Morello, J.P.3
Loisel, T.P.4
Bichet, D.G.5
Barret, C.6
Bouvier, M.7
-
12
-
-
0033578005
-
G-protein-coupled receptor heterodimerization modulates receptor function
-
Jordan, B. A.; Devi, L. A. G-protein-coupled receptor heterodimerization modulates receptor function Nature 1999, 399, 697-700
-
(1999)
Nature
, vol.399
, pp. 697-700
-
-
Jordan, B.A.1
Devi, L.A.2
-
13
-
-
0037124032
-
Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors
-
Hillion, J.; Canals, M.; Torvinen, M.; Casado, V.; Scott, R.; Terasmaa, A.; Hansson, A.; Watson, S.; Olah, M. E.; Mallol, J.; Canela, E. I.; Zoli, M.; Agnati, L. F.; Ibanez, C. F.; Lluis, C.; Franco, R.; Ferre, S.; Fuxe, K. Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors J. Biol. Chem. 2002, 277, 18091-18097
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 18091-18097
-
-
Hillion, J.1
Canals, M.2
Torvinen, M.3
Casado, V.4
Scott, R.5
Terasmaa, A.6
Hansson, A.7
Watson, S.8
Olah, M.E.9
Mallol, J.10
Canela, E.I.11
Zoli, M.12
Agnati, L.F.13
Ibanez, C.F.14
Lluis, C.15
Franco, R.16
Ferre, S.17
Fuxe, K.18
-
14
-
-
3343026033
-
Oligomeric potential of the M2 muscarinic cholinergic receptor
-
Park, P. S. H.; Wells, J. W. Oligomeric potential of the M2 muscarinic cholinergic receptor J. Neurochem. 2004, 90, 537-548
-
(2004)
J. Neurochem.
, vol.90
, pp. 537-548
-
-
Park, P.S.H.1
Wells, J.W.2
-
15
-
-
79959230272
-
Cross-receptor interactions between dopamine D2L and neurotensin NTS1 receptors modulate binding affinities of dopaminergics
-
Koschatzky, S.; Tschammer, N.; Gmeiner, P. Cross-receptor interactions between dopamine D2L and neurotensin NTS1 receptors modulate binding affinities of dopaminergics ACS Chem. Neurosci. 2011, 2, 308-316
-
(2011)
ACS Chem. Neurosci.
, vol.2
, pp. 308-316
-
-
Koschatzky, S.1
Tschammer, N.2
Gmeiner, P.3
-
16
-
-
21344433619
-
Methods to monitor the quaternary structure of G protein-coupled receptors
-
Milligan, G.; Bouvier, M. Methods to monitor the quaternary structure of G protein-coupled receptors FEBS J. 2005, 272, 2914-2925
-
(2005)
FEBS J.
, vol.272
, pp. 2914-2925
-
-
Milligan, G.1
Bouvier, M.2
-
17
-
-
33846440512
-
Technology Insight: Modern methods to monitor protein-protein interactions reveal functional TSH receptor oligomerization
-
Persani, L.; Calebiro, D.; Bonomi, M. Technology Insight: modern methods to monitor protein-protein interactions reveal functional TSH receptor oligomerization Nat. Clin. Pract. Endocrinol. Metab. 2007, 3, 180-190
-
(2007)
Nat. Clin. Pract. Endocrinol. Metab.
, vol.3
, pp. 180-190
-
-
Persani, L.1
Calebiro, D.2
Bonomi, M.3
-
18
-
-
0038576278
-
The fourth transmembrane segment forms the interface of the dopamine D2 receptor homodimer
-
Guo, W.; Shi, L.; Javitch, J. A. The fourth transmembrane segment forms the interface of the dopamine D2 receptor homodimer J. Biol. Chem. 2003, 278, 4385-4388
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 4385-4388
-
-
Guo, W.1
Shi, L.2
Javitch, J.A.3
-
19
-
-
28444493656
-
Crosstalk in G protein-coupled receptors: Changes at the transmembrane homodimer interface determine activation
-
Guo, W.; Shi, L.; Filizola, M.; Weinstein, H.; Javitch, J. A. Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 17495-17500
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 17495-17500
-
-
Guo, W.1
Shi, L.2
Filizola, M.3
Weinstein, H.4
Javitch, J.A.5
-
20
-
-
8344290547
-
Biochemical and biophysical characterization of serotonin 5-HT2C receptor homodimers on the plasma membrane of living cells
-
Herrick-Davis, K.; Grinde, E.; Mazurkiewicz, J. E. Biochemical and biophysical characterization of serotonin 5-HT2C receptor homodimers on the plasma membrane of living cells Biochemistry 2004, 43, 13963-13971
-
(2004)
Biochemistry
, vol.43
, pp. 13963-13971
-
-
Herrick-Davis, K.1
Grinde, E.2
Mazurkiewicz, J.E.3
-
21
-
-
0034724192
-
Detection of β2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET)
-
Angers, S.; Salahpour, A.; Joly, E.; Hilairet, S.; Chelsky, D.; Dennis, M.; Bouvier, M. Detection of β2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET) Proc. Natl. Acad. Sci. U.S.A. 2000, 97, 3684-3689
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 3684-3689
-
-
Angers, S.1
Salahpour, A.2
Joly, E.3
Hilairet, S.4
Chelsky, D.5
Dennis, M.6
Bouvier, M.7
-
22
-
-
21144434720
-
Evidence for native and cloned H3 histamine receptor higher oligomers
-
Shenton, F. C.; Hann, V.; Chazot, P. L. Evidence for native and cloned H3 histamine receptor higher oligomers Inflamm. Res. 2005, 54, 48-49
-
(2005)
Inflamm. Res.
, vol.54
, pp. 48-49
-
-
Shenton, F.C.1
Hann, V.2
Chazot, P.L.3
-
23
-
-
84873155972
-
BRET and time-resolved FRET strategy to study GPCR oligomerization: From cell lines toward native tissues
-
Cottet, M.; Faklaris, O.; Maurel, D.; Scholler, P.; Doumazane, E.; Trinquet, E.; Pin, J. P.; Durroux, T. BRET and time-resolved FRET strategy to study GPCR oligomerization: from cell lines toward native tissues Front. Endocrinol. 2012, 3, 92
-
(2012)
Front. Endocrinol.
, vol.3
, pp. 92
-
-
Cottet, M.1
Faklaris, O.2
Maurel, D.3
Scholler, P.4
Doumazane, E.5
Trinquet, E.6
Pin, J.P.7
Durroux, T.8
-
24
-
-
44449096254
-
Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: Application to GPCR oligomerization
-
Maurel, D.; Comps-Agrar, L.; Brock, C.; Rives, M. L.; Bourrier, E.; Ayoub, M. A.; Bazin, H.; Tinel, N.; Durroux, T.; Prezeau, L.; Trinquet, E.; Pin, J. P. Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerization Nat. Methods 2008, 5, 561-567
-
(2008)
Nat. Methods
, vol.5
, pp. 561-567
-
-
Maurel, D.1
Comps-Agrar, L.2
Brock, C.3
Rives, M.L.4
Bourrier, E.5
Ayoub, M.A.6
Bazin, H.7
Tinel, N.8
Durroux, T.9
Prezeau, L.10
Trinquet, E.11
Pin, J.P.12
-
25
-
-
84873205676
-
Contributions of fluorescence techniques to understanding G protein-coupled receptor dimerisation
-
Goddard, A. D.; Watts, A. Contributions of fluorescence techniques to understanding G protein-coupled receptor dimerisation Biophys. Rev. 2012, 4, 291-298
-
(2012)
Biophys. Rev.
, vol.4
, pp. 291-298
-
-
Goddard, A.D.1
Watts, A.2
-
26
-
-
77955874300
-
Time-resolved FRET between GPCR ligands reveals oligomers in native tissues
-
Albizu, L.; Cottet, M.; Kralikova, M.; Stoev, S.; Seyer, R.; Brabet, I.; Roux, T.; Bazin, H.; Bourrier, E.; Lamarque, L.; Breton, C.; Rives, M. L.; Newman, A.; Javitch, J.; Trinquet, E.; Manning, M.; Pin, J. P.; Mouillac, B.; Durroux, T. Time-resolved FRET between GPCR ligands reveals oligomers in native tissues Nat. Chem. Biol. 2010, 6, 587-594
-
(2010)
Nat. Chem. Biol.
, vol.6
, pp. 587-594
-
-
Albizu, L.1
Cottet, M.2
Kralikova, M.3
Stoev, S.4
Seyer, R.5
Brabet, I.6
Roux, T.7
Bazin, H.8
Bourrier, E.9
Lamarque, L.10
Breton, C.11
Rives, M.L.12
Newman, A.13
Javitch, J.14
Trinquet, E.15
Manning, M.16
Pin, J.P.17
Mouillac, B.18
Durroux, T.19
-
27
-
-
0034976147
-
From fixed to FRAP: Measuring protein mobility and activity in living cells
-
Reits, E. A. J.; Neefjes, J. J. From fixed to FRAP: measuring protein mobility and activity in living cells Nat. Cell Biol. 2001, 3, 145-147
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 145-147
-
-
Reits, E.A.J.1
Neefjes, J.J.2
-
28
-
-
61449236177
-
Analysis of receptor oligomerization by FRAP microscopy
-
Dorsch, S.; Klotz, K. N.; Engelhardt, S.; Lohse, M. J.; Bunemann, M. Analysis of receptor oligomerization by FRAP microscopy Nat. Methods 2009, 6, 225-230
-
(2009)
Nat. Methods
, vol.6
, pp. 225-230
-
-
Dorsch, S.1
Klotz, K.N.2
Engelhardt, S.3
Lohse, M.J.4
Bunemann, M.5
-
29
-
-
0036138908
-
A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications
-
Nagai, T.; Ibata, K.; Park, E. S.; Kubota, M.; Mikoshiba, K.; Miyawaki, A. A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications Nat. Biotechnol. 2002, 20, 87-90
-
(2002)
Nat. Biotechnol.
, vol.20
, pp. 87-90
-
-
Nagai, T.1
Ibata, K.2
Park, E.S.3
Kubota, M.4
Mikoshiba, K.5
Miyawaki, A.6
-
30
-
-
1842424983
-
An improved cyan fluorescent protein variant useful for FRET
-
Rizzo, M. A.; Springer, G. H.; Granada, B.; Piston, D. W. An improved cyan fluorescent protein variant useful for FRET Nat. Biotechnol. 2004, 22, 445-449
-
(2004)
Nat. Biotechnol.
, vol.22
, pp. 445-449
-
-
Rizzo, M.A.1
Springer, G.H.2
Granada, B.3
Piston, D.W.4
-
31
-
-
11144267737
-
Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp red fluorescent protein
-
Shaner, N. C.; Campbell, R. E.; Steinbach, P. A.; Giepmans, B. N. G.; Palmer, A. E.; Tsien, R. Y. Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein Nat. Biotechnol. 2004, 22, 1567-1572
-
(2004)
Nat. Biotechnol.
, vol.22
, pp. 1567-1572
-
-
Shaner, N.C.1
Campbell, R.E.2
Steinbach, P.A.3
Giepmans, B.N.G.4
Palmer, A.E.5
Tsien, R.Y.6
-
32
-
-
48249132926
-
Bimolecular fluorescence complementation (BiFC) analysis as a probe of protein interactions in living cells
-
Kerppola, T. K. Bimolecular fluorescence complementation (BiFC) analysis as a probe of protein interactions in living cells Annu Rev Biophys 2008, 37, 465-487
-
(2008)
Annu Rev Biophys
, vol.37
, pp. 465-487
-
-
Kerppola, T.K.1
-
33
-
-
84860388929
-
CODA-RET reveals functional selectivity as a result of GPCR heteromerization
-
Urizar, E.; Yano, H.; Kolster, R.; Gales, C.; Lambert, N.; Javitch, J. A. CODA-RET reveals functional selectivity as a result of GPCR heteromerization Nat. Chem. Biol. 2011, 7, 624-630
-
(2011)
Nat. Chem. Biol.
, vol.7
, pp. 624-630
-
-
Urizar, E.1
Yano, H.2
Kolster, R.3
Gales, C.4
Lambert, N.5
Javitch, J.A.6
-
34
-
-
78149330589
-
Imaging with total internal reflection fluorescence microscopy for the cell biologist
-
Mattheyses, A. L.; Simon, S. M.; Rappoport, J. Z. Imaging with total internal reflection fluorescence microscopy for the cell biologist J. Cell Sci. 2010, 123, 3621-3628
-
(2010)
J. Cell Sci.
, vol.123
, pp. 3621-3628
-
-
Mattheyses, A.L.1
Simon, S.M.2
Rappoport, J.Z.3
-
35
-
-
77249150932
-
Formation and dissociation of M1 muscarinic receptor dimers seen by total internal reflection fluorescence imaging of single molecules
-
Hern, J. A.; Baig, A. H.; Mashanov, G. I.; Birdsall, B.; Corrie, J. E. T.; Lazareno, S.; Molloy, J. E.; Birdsall, N. J. M. Formation and dissociation of M1 muscarinic receptor dimers seen by total internal reflection fluorescence imaging of single molecules Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 2693-2698
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 2693-2698
-
-
Hern, J.A.1
Baig, A.H.2
Mashanov, G.I.3
Birdsall, B.4
Corrie, J.E.T.5
Lazareno, S.6
Molloy, J.E.7
Birdsall, N.J.M.8
-
36
-
-
84872195772
-
Single-molecule analysis of fluorescently labeled G-protein-coupled receptors reveals complexes with distinct dynamics and organization
-
Calebiro, D.; Rieken, F.; Wagner, J.; Sungkaworn, T.; Zabel, U.; Borzi, A.; Cocucci, E.; Zurn, A.; Lohse, M. J. Single-molecule analysis of fluorescently labeled G-protein-coupled receptors reveals complexes with distinct dynamics and organization Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 743-748
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.110
, pp. 743-748
-
-
Calebiro, D.1
Rieken, F.2
Wagner, J.3
Sungkaworn, T.4
Zabel, U.5
Borzi, A.6
Cocucci, E.7
Zurn, A.8
Lohse, M.J.9
-
37
-
-
35248877040
-
Novel pharmacological applications of G-protein-coupled receptor-G protein fusions
-
Milligan, G.; Parenty, G.; Stoddart, L. A.; Lane, J. R. Novel pharmacological applications of G-protein-coupled receptor-G protein fusions Curr. Opin. Pharmacol. 2007, 7, 521-526
-
(2007)
Curr. Opin. Pharmacol.
, vol.7
, pp. 521-526
-
-
Milligan, G.1
Parenty, G.2
Stoddart, L.A.3
Lane, J.R.4
-
38
-
-
69249158290
-
Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation
-
Han, Y.; Moreira, I. S.; Urizar, E.; Weinstein, H.; Javitch, J. A. Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation Nat. Chem. Biol. 2009, 5, 688-695
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 688-695
-
-
Han, Y.1
Moreira, I.S.2
Urizar, E.3
Weinstein, H.4
Javitch, J.A.5
-
39
-
-
78650147139
-
Allostery at G protein-coupled receptor homo- and heteromers: Uncharted pharmacological landscapes
-
Smith, N. J.; Milligan, G. Allostery at G protein-coupled receptor homo- and heteromers: uncharted pharmacological landscapes Pharmacol. Rev. 2010, 62, 701-725
-
(2010)
Pharmacol. Rev.
, vol.62
, pp. 701-725
-
-
Smith, N.J.1
Milligan, G.2
-
40
-
-
85027927015
-
Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists
-
Wu, B.; Chien, E. Y.; Mol, C. D.; Fenalti, G.; Liu, W.; Katritch, V.; Abagyan, R.; Brooun, A.; Wells, P.; Bi, F. C.; Hamel, D. J.; Kuhn, P.; Handel, T. M.; Cherezov, V.; Stevens, R. C. Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists Science 2010, 330, 1066-1071
-
(2010)
Science
, vol.330
, pp. 1066-1071
-
-
Wu, B.1
Chien, E.Y.2
Mol, C.D.3
Fenalti, G.4
Liu, W.5
Katritch, V.6
Abagyan, R.7
Brooun, A.8
Wells, P.9
Bi, F.C.10
Hamel, D.J.11
Kuhn, P.12
Handel, T.M.13
Cherezov, V.14
Stevens, R.C.15
-
41
-
-
84861096654
-
Crystal structure of the micro-opioid receptor bound to a morphinan antagonist
-
Manglik, A.; Kruse, A. C.; Kobilka, T. S.; Thian, F. S.; Mathiesen, J. M.; Sunahara, R. K.; Pardo, L.; Weis, W. I.; Kobilka, B. K.; Granier, S. Crystal structure of the micro-opioid receptor bound to a morphinan antagonist Nature 2012, 485, 321-326
-
(2012)
Nature
, vol.485
, pp. 321-326
-
-
Manglik, A.1
Kruse, A.C.2
Kobilka, T.S.3
Thian, F.S.4
Mathiesen, J.M.5
Sunahara, R.K.6
Pardo, L.7
Weis, W.I.8
Kobilka, B.K.9
Granier, S.10
-
42
-
-
84862777742
-
Structure of the human κ-opioid receptor in complex with JDTic
-
Wu, H.; Wacker, D.; Mileni, M.; Katritch, V.; Han, G. W.; Vardy, E.; Liu, W.; Thompson, A. A.; Huang, X. P.; Carroll, F. I.; Mascarella, S. W.; Westkaemper, R. B.; Mosier, P. D.; Roth, B. L.; Cherezov, V.; Stevens, R. C. Structure of the human κ-opioid receptor in complex with JDTic Nature 2012, 485, 327-332
-
(2012)
Nature
, vol.485
, pp. 327-332
-
-
Wu, H.1
Wacker, D.2
Mileni, M.3
Katritch, V.4
Han, G.W.5
Vardy, E.6
Liu, W.7
Thompson, A.A.8
Huang, X.P.9
Carroll, F.I.10
Mascarella, S.W.11
Westkaemper, R.B.12
Mosier, P.D.13
Roth, B.L.14
Cherezov, V.15
Stevens, R.C.16
-
43
-
-
33847419390
-
International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers
-
Pin, J. P.; Neubig, R.; Bouvier, M.; Devi, L.; Filizola, M.; Javitch, J. A.; Lohse, M. J.; Milligan, G.; Palczewski, K.; Parmentier, M.; Spedding, M. International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers Pharmacol. Rev. 2007, 59, 5-13
-
(2007)
Pharmacol. Rev.
, vol.59
, pp. 5-13
-
-
Pin, J.P.1
Neubig, R.2
Bouvier, M.3
Devi, L.4
Filizola, M.5
Javitch, J.A.6
Lohse, M.J.7
Milligan, G.8
Palczewski, K.9
Parmentier, M.10
Spedding, M.11
-
44
-
-
1842687121
-
A role for heterodimerization of mu and delta opiate receptors in enhancing morphine analgesia
-
Gomes, I.; Gupta, A.; Filipovska, J.; Szeto, H. H.; Pintar, J. E.; Devi, L. A. A role for heterodimerization of mu and delta opiate receptors in enhancing morphine analgesia Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 5135-5139
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 5135-5139
-
-
Gomes, I.1
Gupta, A.2
Filipovska, J.3
Szeto, H.H.4
Pintar, J.E.5
Devi, L.A.6
-
45
-
-
33645802812
-
Allosteric modulation of binding properties between units of chemokine receptor homo- and hetero-oligomers
-
Springael, J. Y.; Le Minh, P. N.; Urizar, E.; Costagliola, S.; Vassart, G.; Parmentier, M. Allosteric modulation of binding properties between units of chemokine receptor homo- and hetero-oligomers Mol. Pharmacol. 2006, 69, 1652-1661
-
(2006)
Mol. Pharmacol.
, vol.69
, pp. 1652-1661
-
-
Springael, J.Y.1
Le Minh, P.N.2
Urizar, E.3
Costagliola, S.4
Vassart, G.5
Parmentier, M.6
-
46
-
-
38349054282
-
Conformational cross-talk between α2A-adrenergic and μ-opioid receptors controls cell signaling
-
Vilardaga, J. P.; Nikolaev, V. O.; Lorenz, K.; Ferrandon, S.; Zhuang, Z. J.; Lohse, M. J. Conformational cross-talk between α2A-adrenergic and μ-opioid receptors controls cell signaling Nat. Chem. Biol. 2008, 4, 126-131
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 126-131
-
-
Vilardaga, J.P.1
Nikolaev, V.O.2
Lorenz, K.3
Ferrandon, S.4
Zhuang, Z.J.5
Lohse, M.J.6
-
47
-
-
0034618268
-
AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration
-
AbdAlla, S.; Lother, H.; Quitterer, U. AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration Nature 2000, 407, 94-98
-
(2000)
Nature
, vol.407
, pp. 94-98
-
-
Abdalla, S.1
Lother, H.2
Quitterer, U.3
-
48
-
-
33846328669
-
D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of G(q)/11 in the striatum
-
Rashid, A. J.; So, C. H.; Kong, M. M. C.; Furtak, T.; El-Ghundi, M.; Cheng, R.; O'Dowd, B. F.; George, S. R. D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of G(q)/11 in the striatum Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 654-659
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 654-659
-
-
Rashid, A.J.1
So, C.H.2
Kong, M.M.C.3
Furtak, T.4
El-Ghundi, M.5
Cheng, R.6
O'Dowd, B.F.7
George, S.R.8
-
49
-
-
1342344556
-
D2 dopamine receptors modulate Gα-subunit coupling of the CB1 cannabinoid receptor
-
Jarrahian, A.; Watts, V. J.; Barker, E. L. D2 dopamine receptors modulate Gα-subunit coupling of the CB1 cannabinoid receptor J. Pharmacol. Exp. Ther. 2004, 308, 880-886
-
(2004)
J. Pharmacol. Exp. Ther.
, vol.308
, pp. 880-886
-
-
Jarrahian, A.1
Watts, V.J.2
Barker, E.L.3
-
50
-
-
34547759878
-
Receptor heterodimerization leads to a switch in signaling: β-arrestin2-mediated ERK activation by μ-δ Opioid receptor heterodimers
-
Rozenfeld, R.; Devi, L. A. Receptor heterodimerization leads to a switch in signaling: β-arrestin2-mediated ERK activation by μ-δ opioid receptor heterodimers FASEB J. 2007, 21, 2455-2465
-
(2007)
FASEB J.
, vol.21
, pp. 2455-2465
-
-
Rozenfeld, R.1
Devi, L.A.2
-
51
-
-
34447534333
-
Augmentation of spinal morphine analgesia and inhibition of tolerance by low doses of mu- and delta-opioid receptor antagonists
-
Abul-Husn, N. S.; Sutak, M.; Milne, B.; Jhamandas, K. Augmentation of spinal morphine analgesia and inhibition of tolerance by low doses of mu- and delta-opioid receptor antagonists Br. J. Pharmacol. 2007, 151, 877-887
-
(2007)
Br. J. Pharmacol.
, vol.151
, pp. 877-887
-
-
Abul-Husn, N.S.1
Sutak, M.2
Milne, B.3
Jhamandas, K.4
-
52
-
-
0033198831
-
Retention of supraspinal delta-like analgesia and loss of morphine tolerance in δ opioid receptor knockout mice
-
Zhu, Y.; King, M. A.; Schuller, A. G.; Nitsche, J. F.; Reidl, M.; Elde, R. P.; Unterwald, E.; Pasternak, G. W.; Pintar, J. E. Retention of supraspinal delta-like analgesia and loss of morphine tolerance in δ opioid receptor knockout mice Neuron 1999, 24, 243-252
-
(1999)
Neuron
, vol.24
, pp. 243-252
-
-
Zhu, Y.1
King, M.A.2
Schuller, A.G.3
Nitsche, J.F.4
Reidl, M.5
Elde, R.P.6
Unterwald, E.7
Pasternak, G.W.8
Pintar, J.E.9
-
53
-
-
0034619796
-
μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence
-
Bohn, L. M.; Gainetdinov, R. R.; Lin, F. T.; Lefkowitz, R. J.; Caron, M. G. μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence Nature 2000, 408, 720-723
-
(2000)
Nature
, vol.408
, pp. 720-723
-
-
Bohn, L.M.1
Gainetdinov, R.R.2
Lin, F.T.3
Lefkowitz, R.J.4
Caron, M.G.5
-
54
-
-
0033924207
-
Inhibition of cell surface expression by mutant receptors demonstrates that D2 dopamine receptors exist as oligomers in the cell
-
Lee, S. P.; O'Dowd, B. F.; Ng, G. Y.; Varghese, G.; Akil, H.; Mansour, A.; Nguyen, T.; George, S. R. Inhibition of cell surface expression by mutant receptors demonstrates that D2 dopamine receptors exist as oligomers in the cell Mol. Pharmacol. 2000, 58, 120-128
-
(2000)
Mol. Pharmacol.
, vol.58
, pp. 120-128
-
-
Lee, S.P.1
O'Dowd, B.F.2
Ng, G.Y.3
Varghese, G.4
Akil, H.5
Mansour, A.6
Nguyen, T.7
George, S.R.8
-
55
-
-
0032506160
-
Truncated V2 vasopressin receptors as negative regulators of wild-type V2 receptor function
-
Zhu, X.; Wess, J. Truncated V2 vasopressin receptors as negative regulators of wild-type V2 receptor function Biochemistry 1998, 37, 15773-15784
-
(1998)
Biochemistry
, vol.37
, pp. 15773-15784
-
-
Zhu, X.1
Wess, J.2
-
56
-
-
4043125390
-
Homodimerization of the beta2-adrenergic receptor as a prerequisite for cell surface targeting
-
Salahpour, A.; Angers, S.; Mercier, J. F.; Lagace, M.; Marullo, S.; Bouvier, M. Homodimerization of the beta2-adrenergic receptor as a prerequisite for cell surface targeting J. Biol. Chem. 2004, 279, 33390-33397
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 33390-33397
-
-
Salahpour, A.1
Angers, S.2
Mercier, J.F.3
Lagace, M.4
Marullo, S.5
Bouvier, M.6
-
57
-
-
23344447877
-
The CXCR1 and CXCR2 receptors form constitutive homo- and heterodimers selectively and with equal apparent affinities
-
Wilson, S.; Wilkinson, G.; Milligan, G. The CXCR1 and CXCR2 receptors form constitutive homo- and heterodimers selectively and with equal apparent affinities J. Biol. Chem. 2005, 280, 28663-28674
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 28663-28674
-
-
Wilson, S.1
Wilkinson, G.2
Milligan, G.3
-
58
-
-
0036236878
-
Differences in the cellular localization and agonist-mediated internalization properties of the α1-adrenoceptor subtypes
-
Chalothorn, D.; McCune, D. F.; Edelmann, S. E.; Garcia-Cazarin, M. L.; Tsujimoto, G.; Piascik, M. T. Differences in the cellular localization and agonist-mediated internalization properties of the α1-adrenoceptor subtypes Mol. Pharmacol. 2002, 61, 1008-1016
-
(2002)
Mol. Pharmacol.
, vol.61
, pp. 1008-1016
-
-
Chalothorn, D.1
McCune, D.F.2
Edelmann, S.E.3
Garcia-Cazarin, M.L.4
Tsujimoto, G.5
Piascik, M.T.6
-
59
-
-
0346366929
-
Subtype-specific dimerization of α1-adrenoceptors: Effects on receptor expression and pharmacological properties
-
Uberti, M. A.; Hall, R. A.; Minneman, K. P. Subtype-specific dimerization of α1-adrenoceptors: effects on receptor expression and pharmacological properties Mol. Pharmacol. 2003, 64, 1379-1390
-
(2003)
Mol. Pharmacol.
, vol.64
, pp. 1379-1390
-
-
Uberti, M.A.1
Hall, R.A.2
Minneman, K.P.3
-
60
-
-
78650958254
-
Facilitation of mu-opioid receptor activity by preventing delta-opioid receptor-mediated codegradation
-
He, S. Q.; Zhang, Z. N.; Guan, J. S.; Liu, H. R.; Zhao, B.; Wang, H. B.; Li, Q.; Yang, H.; Luo, J.; Li, Z. Y.; Wang, Q.; Lu, Y. J.; Bao, L.; Zhang, X. Facilitation of mu-opioid receptor activity by preventing delta-opioid receptor-mediated codegradation Neuron 2011, 69, 120-131
-
(2011)
Neuron
, vol.69
, pp. 120-131
-
-
He, S.Q.1
Zhang, Z.N.2
Guan, J.S.3
Liu, H.R.4
Zhao, B.5
Wang, H.B.6
Li, Q.7
Yang, H.8
Luo, J.9
Li, Z.Y.10
Wang, Q.11
Lu, Y.J.12
Bao, L.13
Zhang, X.14
-
61
-
-
77957777572
-
Hetero-dimerization of serotonin 5-HT(2A) and dopamine D(2) receptors
-
Lukasiewicz, S.; Polit, A.; Kedracka-Krok, S.; Wedzony, K.; Mackowiak, M.; Dziedzicka-Wasylewska, M. Hetero-dimerization of serotonin 5-HT(2A) and dopamine D(2) receptors Biochim. Biophys. Acta 2010, 1803, 1347-1358
-
(2010)
Biochim. Biophys. Acta
, vol.1803
, pp. 1347-1358
-
-
Lukasiewicz, S.1
Polit, A.2
Kedracka-Krok, S.3
Wedzony, K.4
Mackowiak, M.5
Dziedzicka-Wasylewska, M.6
-
62
-
-
79959993845
-
Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors
-
Albizu, L.; Holloway, T.; Gonzalez-Maeso, J.; Sealfon, S. C. Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors Neuropharmacology 2011, 61, 770-777
-
(2011)
Neuropharmacology
, vol.61
, pp. 770-777
-
-
Albizu, L.1
Holloway, T.2
Gonzalez-Maeso, J.3
Sealfon, S.C.4
-
63
-
-
20444416043
-
Constitutive dimerization of human serotonin 5-HT4 receptors in living cells
-
Berthouze, M.; Ayoub, M.; Russo, O.; Rivail, L.; Sicsic, S.; Fischmeister, R.; Berque-Bestel, I.; Jockers, R.; Lezoualc'h, F. Constitutive dimerization of human serotonin 5-HT4 receptors in living cells FEBS Lett. 2005, 579, 2973-2980
-
(2005)
FEBS Lett.
, vol.579
, pp. 2973-2980
-
-
Berthouze, M.1
Ayoub, M.2
Russo, O.3
Rivail, L.4
Sicsic, S.5
Fischmeister, R.6
Berque-Bestel, I.7
Jockers, R.8
Lezoualc'H, F.9
-
64
-
-
0141890300
-
Oligomerization of the alpha 1a- and alpha 1b-adrenergic receptor subtypes. Potential implications in receptor internalization
-
Stanasila, L.; Perez, J. B.; Vogel, H.; Cotecchia, S. Oligomerization of the alpha 1a- and alpha 1b-adrenergic receptor subtypes. Potential implications in receptor internalization J. Biol. Chem. 2003, 278, 40239-40251
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 40239-40251
-
-
Stanasila, L.1
Perez, J.B.2
Vogel, H.3
Cotecchia, S.4
-
65
-
-
0142149074
-
Dimers of class A G protein-coupled receptors function via agonist-mediated trans-activation of associated G proteins
-
Carrillo, J. J.; Pediani, J.; Milligan, G. Dimers of class A G protein-coupled receptors function via agonist-mediated trans-activation of associated G proteins J. Biol. Chem. 2003, 278, 42578-42587
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 42578-42587
-
-
Carrillo, J.J.1
Pediani, J.2
Milligan, G.3
-
66
-
-
2442597256
-
Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors
-
Hague, C.; Uberti, M. A.; Chen, Z.; Hall, R. A.; Minneman, K. P. Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors J. Biol. Chem. 2004, 279, 15541-15549
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 15541-15549
-
-
Hague, C.1
Uberti, M.A.2
Chen, Z.3
Hall, R.A.4
Minneman, K.P.5
-
67
-
-
30044447860
-
Heterodimers of alpha1B- and alpha1D-adrenergic receptors form a single functional entity
-
Hague, C.; Lee, S. E.; Chen, Z.; Prinster, S. C.; Hall, R. A.; Minneman, K. P. Heterodimers of alpha1B- and alpha1D-adrenergic receptors form a single functional entity Mol. Pharmacol. 2006, 69, 45-55
-
(2006)
Mol. Pharmacol.
, vol.69
, pp. 45-55
-
-
Hague, C.1
Lee, S.E.2
Chen, Z.3
Prinster, S.C.4
Hall, R.A.5
Minneman, K.P.6
-
68
-
-
0037518126
-
Heterodimerization of alpha 2A- and beta 1-adrenergic receptors
-
Xu, J.; He, J.; Castleberry, A. M.; Balasubramanian, S.; Lau, A. G.; Hall, R. A. Heterodimerization of alpha 2A- and beta 1-adrenergic receptors J. Biol. Chem. 2003, 278, 10770-10777
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 10770-10777
-
-
Xu, J.1
He, J.2
Castleberry, A.M.3
Balasubramanian, S.4
Lau, A.G.5
Hall, R.A.6
-
69
-
-
33644551294
-
Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers
-
Ciruela, F.; Casado, V.; Rodrigues, R. J.; Lujan, R.; Burgueno, J.; Canals, M.; Borycz, J.; Rebola, N.; Goldberg, S. R.; Mallol, J.; Cortes, A.; Canela, E. I.; Lopez-Gimenez, J. F.; Milligan, G.; Lluis, C.; Cunha, R. A.; Ferre, S.; Franco, R. Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers J. Neurosci. 2006, 26, 2080-2087
-
(2006)
J. Neurosci.
, vol.26
, pp. 2080-2087
-
-
Ciruela, F.1
Casado, V.2
Rodrigues, R.J.3
Lujan, R.4
Burgueno, J.5
Canals, M.6
Borycz, J.7
Rebola, N.8
Goldberg, S.R.9
Mallol, J.10
Cortes, A.11
Canela, E.I.12
Lopez-Gimenez, J.F.13
Milligan, G.14
Lluis, C.15
Cunha, R.A.16
Ferre, S.17
Franco, R.18
-
70
-
-
0024463015
-
Adenosine receptor coupling to adenylate cyclase of rat ventricular myocyte membranes
-
Romano, F. D.; MacDonald, S. G.; Dobson, J. G., Jr. Adenosine receptor coupling to adenylate cyclase of rat ventricular myocyte membranes Am. J. Physiol. 1989, 257, H1088-H1095
-
(1989)
Am. J. Physiol.
, vol.257
-
-
Romano, F.D.1
MacDonald, S.G.2
Dobson Jr., J.G.3
-
71
-
-
0025194765
-
Characterization of adenosine A1 receptors in intact DDT1 MF-2 smooth muscle cells
-
Gerwins, P.; Nordstedt, C.; Fredholm, B. B. Characterization of adenosine A1 receptors in intact DDT1 MF-2 smooth muscle cells Mol. Pharmacol. 1990, 38, 660-666
-
(1990)
Mol. Pharmacol.
, vol.38
, pp. 660-666
-
-
Gerwins, P.1
Nordstedt, C.2
Fredholm, B.B.3
-
72
-
-
0034682445
-
Dopamine D1 and adenosine A1 receptors form functionally interacting heteromeric complexes
-
Gines, S.; Hillion, J.; Torvinen, M.; Le Crom, S.; Casado, V.; Canela, E. I.; Rondin, S.; Lew, J. Y.; Watson, S.; Zoli, M.; Agnati, L. F.; Verniera, P.; Lluis, C.; Ferre, S.; Fuxe, K.; Franco, R. Dopamine D1 and adenosine A1 receptors form functionally interacting heteromeric complexes Proc. Natl. Acad. Sci. U.S.A. 2000, 97, 8606-8611
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 8606-8611
-
-
Gines, S.1
Hillion, J.2
Torvinen, M.3
Le Crom, S.4
Casado, V.5
Canela, E.I.6
Rondin, S.7
Lew, J.Y.8
Watson, S.9
Zoli, M.10
Agnati, L.F.11
Verniera, P.12
Lluis, C.13
Ferre, S.14
Fuxe, K.15
Franco, R.16
-
73
-
-
34548538764
-
Striatal adenosine A(2A) and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids
-
Carriba, P.; Ortiz, O.; Patkar, K.; Justinova, Z.; Stroik, J.; Themann, A.; Muller, C.; Woods, A. S.; Hope, B. T.; Ciruela, F.; Casado, V.; Canela, E. I.; Lluis, C.; Goldberg, S. R.; Moratalla, R.; Franco, R.; Ferre, S. Striatal adenosine A(2A) and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids Neuropsychopharmacology 2007, 32, 2249-2259
-
(2007)
Neuropsychopharmacology
, vol.32
, pp. 2249-2259
-
-
Carriba, P.1
Ortiz, O.2
Patkar, K.3
Justinova, Z.4
Stroik, J.5
Themann, A.6
Muller, C.7
Woods, A.S.8
Hope, B.T.9
Ciruela, F.10
Casado, V.11
Canela, E.I.12
Lluis, C.13
Goldberg, S.R.14
Moratalla, R.15
Franco, R.16
Ferre, S.17
-
74
-
-
0344875553
-
Adenosine A2A-dopamine D2 receptor-receptor heteromerization: Qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer
-
Canals, M.; Marcellino, D.; Fanelli, F.; Ciruela, F.; de Benedetti, P.; Goldberg, S. R.; Neve, K.; Fuxe, K.; Agnati, L. F.; Woods, A. S.; Ferre, S.; Lluis, C.; Bouvier, M.; Franco, R. Adenosine A2A-dopamine D2 receptor-receptor heteromerization: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer J. Biol. Chem. 2003, 278, 46741-46749
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 46741-46749
-
-
Canals, M.1
Marcellino, D.2
Fanelli, F.3
Ciruela, F.4
De Benedetti, P.5
Goldberg, S.R.6
Neve, K.7
Fuxe, K.8
Agnati, L.F.9
Woods, A.S.10
Ferre, S.11
Lluis, C.12
Bouvier, M.13
Franco, R.14
-
75
-
-
0037870163
-
Oligomerization of adenosine A2A and dopamine D2 receptors in living cells
-
Kamiya, T.; Saitoh, O.; Yoshioka, K.; Nakata, H. Oligomerization of adenosine A2A and dopamine D2 receptors in living cells Biochem. Biophys. Res. Commun. 2003, 306, 544-549
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.306
, pp. 544-549
-
-
Kamiya, T.1
Saitoh, O.2
Yoshioka, K.3
Nakata, H.4
-
76
-
-
2942513004
-
Striatal plasticity at the network level. Focus on adenosine A2A and D2 interactions in models of Parkinson's disease
-
Tanganelli, S.; Sandager Nielsen, K.; Ferraro, L.; Antonelli, T.; Kehr, J.; Franco, R.; Ferre, S.; Agnati, L. F.; Fuxe, K.; Scheel-Kruger, J. Striatal plasticity at the network level. Focus on adenosine A2A and D2 interactions in models of Parkinson's disease Parkinsonism Relat. Disord. 2004, 10, 273-280
-
(2004)
Parkinsonism Relat. Disord.
, vol.10
, pp. 273-280
-
-
Tanganelli, S.1
Sandager Nielsen, K.2
Ferraro, L.3
Antonelli, T.4
Kehr, J.5
Franco, R.6
Ferre, S.7
Agnati, L.F.8
Fuxe, K.9
Scheel-Kruger, J.10
-
77
-
-
10744224952
-
Receptor heteromerization in adenosine A2A receptor signaling: Relevance for striatal function and Parkinson's disease
-
Fuxe, K.; Agnati, L. F.; Jacobsen, K.; Hillion, J.; Canals, M.; Torvinen, M.; Tinner-Staines, B.; Staines, W.; Rosin, D.; Terasmaa, A.; Popoli, P.; Leo, G.; Vergoni, V.; Lluis, C.; Ciruela, F.; Franco, R.; Ferre, S. Receptor heteromerization in adenosine A2A receptor signaling: relevance for striatal function and Parkinson's disease Neurology 2003, 61, 19-23
-
(2003)
Neurology
, vol.61
, pp. 19-23
-
-
Fuxe, K.1
Agnati, L.F.2
Jacobsen, K.3
Hillion, J.4
Canals, M.5
Torvinen, M.6
Tinner-Staines, B.7
Staines, W.8
Rosin, D.9
Terasmaa, A.10
Popoli, P.11
Leo, G.12
Vergoni, V.13
Lluis, C.14
Ciruela, F.15
Franco, R.16
Ferre, S.17
-
78
-
-
25844477182
-
Adenosine A2A and dopamine D2 heteromeric receptor complexes and their function
-
Fuxe, K.; Ferre, S.; Canals, M.; Torvinen, M.; Terasmaa, A.; Marcellino, D.; Goldberg, S. R.; Staines, W.; Jacobsen, K. X.; Lluis, C.; Woods, A. S.; Agnati, L. F.; Franco, R. Adenosine A2A and dopamine D2 heteromeric receptor complexes and their function J. Mol. Neurosci. 2005, 26, 209-220
-
(2005)
J. Mol. Neurosci.
, vol.26
, pp. 209-220
-
-
Fuxe, K.1
Ferre, S.2
Canals, M.3
Torvinen, M.4
Terasmaa, A.5
Marcellino, D.6
Goldberg, S.R.7
Staines, W.8
Jacobsen, K.X.9
Lluis, C.10
Woods, A.S.11
Agnati, L.F.12
Franco, R.13
-
79
-
-
0034785580
-
Increased AT(1) receptor heterodimers in preeclampsia mediate enhanced angiotensin II responsiveness
-
AbdAlla, S.; Lother, H.; el Massiery, A.; Quitterer, U. Increased AT(1) receptor heterodimers in preeclampsia mediate enhanced angiotensin II responsiveness Nat. Med. 2001, 7, 1003-1009
-
(2001)
Nat. Med.
, vol.7
, pp. 1003-1009
-
-
Abdalla, S.1
Lother, H.2
El Massiery, A.3
Quitterer, U.4
-
80
-
-
59449103028
-
Lack of evidence for AT1R/B2R heterodimerization in COS-7, HEK293, and NIH3T3 cells: How common is the AT1R/B2R heterodimer?
-
Hansen, J. L.; Hansen, J. T.; Speerschneider, T.; Lyngso, C.; Erikstrup, N.; Burstein, E. S.; Weiner, D. M.; Walther, T.; Makita, N.; Iiri, T.; Merten, N.; Kostenis, E.; Sheikh, S. P. Lack of evidence for AT1R/B2R heterodimerization in COS-7, HEK293, and NIH3T3 cells: How common is the AT1R/B2R heterodimer? J. Biol. Chem. 2009, 284, 1831-1839
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 1831-1839
-
-
Hansen, J.L.1
Hansen, J.T.2
Speerschneider, T.3
Lyngso, C.4
Erikstrup, N.5
Burstein, E.S.6
Weiner, D.M.7
Walther, T.8
Makita, N.9
Iiri, T.10
Merten, N.11
Kostenis, E.12
Sheikh, S.P.13
-
81
-
-
0141841603
-
Dual inhibition of beta-adrenergic and angiotensin II receptors by a single antagonist: A functional role for receptor-receptor interaction in vivo
-
Barki-Harrington, L.; Luttrell, L. M.; Rockman, H. A. Dual inhibition of beta-adrenergic and angiotensin II receptors by a single antagonist: a functional role for receptor-receptor interaction in vivo Circulation 2003, 108, 1611-1618
-
(2003)
Circulation
, vol.108
, pp. 1611-1618
-
-
Barki-Harrington, L.1
Luttrell, L.M.2
Rockman, H.A.3
-
82
-
-
79958865842
-
AT1R-CB(1)R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II
-
Rozenfeld, R.; Gupta, A.; Gagnidze, K.; Lim, M. P.; Gomes, I.; Lee-Ramos, D.; Nieto, N.; Devi, L. A. AT1R-CB(1)R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II EMBO J. 2011, 30, 2350-2363
-
(2011)
EMBO J.
, vol.30
, pp. 2350-2363
-
-
Rozenfeld, R.1
Gupta, A.2
Gagnidze, K.3
Lim, M.P.4
Gomes, I.5
Lee-Ramos, D.6
Nieto, N.7
Devi, L.A.8
-
83
-
-
0037160105
-
Quantitative assessment of beta 1- and beta 2-adrenergic receptor homo- and heterodimerization by bioluminescence resonance energy transfer
-
Mercier, J. F.; Salahpour, A.; Angers, S.; Breit, A.; Bouvier, M. Quantitative assessment of beta 1- and beta 2-adrenergic receptor homo- and heterodimerization by bioluminescence resonance energy transfer J. Biol. Chem. 2002, 277, 44925-44931
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 44925-44931
-
-
Mercier, J.F.1
Salahpour, A.2
Angers, S.3
Breit, A.4
Bouvier, M.5
-
84
-
-
23344449115
-
Heterodimerization of beta1- and beta2-adrenergic receptor subtypes optimizes beta-adrenergic modulation of cardiac contractility
-
Zhu, W. Z.; Chakir, K.; Zhang, S.; Yang, D.; Lavoie, C.; Bouvier, M.; Hebert, T. E.; Lakatta, E. G.; Cheng, H.; Xiao, R. P. Heterodimerization of beta1- and beta2-adrenergic receptor subtypes optimizes beta-adrenergic modulation of cardiac contractility Circ. Res. 2005, 97, 244-251
-
(2005)
Circ. Res.
, vol.97
, pp. 244-251
-
-
Zhu, W.Z.1
Chakir, K.2
Zhang, S.3
Yang, D.4
Lavoie, C.5
Bouvier, M.6
Hebert, T.E.7
Lakatta, E.G.8
Cheng, H.9
Xiao, R.P.10
-
85
-
-
0035793079
-
Oligomerization of opioid receptors with beta 2-adrenergic receptors: A role in trafficking and mitogen-activated protein kinase activation
-
Jordan, B. A.; Trapaidze, N.; Gomes, I.; Nivarthi, R.; Devi, L. A. Oligomerization of opioid receptors with beta 2-adrenergic receptors: a role in trafficking and mitogen-activated protein kinase activation Proc. Natl. Acad. Sci. U.S.A. 2001, 98, 343-348
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 343-348
-
-
Jordan, B.A.1
Trapaidze, N.2
Gomes, I.3
Nivarthi, R.4
Devi, L.A.5
-
86
-
-
80755139562
-
Allosteric interactions between the oxytocin receptor and the beta2-adrenergic receptor in the modulation of ERK1/2 activation are mediated by heterodimerization
-
Wrzal, P. K.; Devost, D.; Petrin, D.; Goupil, E.; Iorio-Morin, C.; Laporte, S. A.; Zingg, H. H.; Hebert, T. E. Allosteric interactions between the oxytocin receptor and the beta2-adrenergic receptor in the modulation of ERK1/2 activation are mediated by heterodimerization Cell. Signalling 2012, 24, 342-350
-
(2012)
Cell. Signalling
, vol.24
, pp. 342-350
-
-
Wrzal, P.K.1
Devost, D.2
Petrin, D.3
Goupil, E.4
Iorio-Morin, C.5
Laporte, S.A.6
Zingg, H.H.7
Hebert, T.E.8
-
87
-
-
40849137554
-
Antagonistic cannabinoid CB1/dopamine D2 receptor interactions in striatal CB1/D2 heteromers. A combined neurochemical and behavioral analysis
-
Marcellino, D.; Carriba, P.; Filip, M.; Borgkvist, A.; Frankowska, M.; Bellido, I.; Tanganelli, S.; Muller, C. E.; Fisone, G.; Lluis, C.; Agnati, L. F.; Franco, R.; Fuxe, K. Antagonistic cannabinoid CB1/dopamine D2 receptor interactions in striatal CB1/D2 heteromers. A combined neurochemical and behavioral analysis Neuropharmacology 2008, 54, 815-823
-
(2008)
Neuropharmacology
, vol.54
, pp. 815-823
-
-
Marcellino, D.1
Carriba, P.2
Filip, M.3
Borgkvist, A.4
Frankowska, M.5
Bellido, I.6
Tanganelli, S.7
Muller, C.E.8
Fisone, G.9
Lluis, C.10
Agnati, L.F.11
Franco, R.12
Fuxe, K.13
-
88
-
-
17844410926
-
Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors enhances heterodimer formation: A mechanism for receptor cross-talk?
-
Kearn, C. S.; Blake-Palmer, K.; Daniel, E.; Mackie, K.; Glass, M. Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors enhances heterodimer formation: a mechanism for receptor cross-talk? Mol. Pharmacol. 2005, 67, 1697-1704
-
(2005)
Mol. Pharmacol.
, vol.67
, pp. 1697-1704
-
-
Kearn, C.S.1
Blake-Palmer, K.2
Daniel, E.3
Mackie, K.4
Glass, M.5
-
89
-
-
84855317125
-
Receptor heteromerization expands the repertoire of cannabinoid signaling in rodent neurons
-
Rozenfeld, R.; Bushlin, I.; Gomes, I.; Tzavaras, N.; Gupta, A.; Neves, S.; Battini, L.; Gusella, G. L.; Lachmann, A.; Ma'ayan, A.; Blitzer, R. D.; Devi, L. A. Receptor heteromerization expands the repertoire of cannabinoid signaling in rodent neurons PLoS One 2012, 7, e29239
-
(2012)
PLoS One
, vol.7
, pp. 29239
-
-
Rozenfeld, R.1
Bushlin, I.2
Gomes, I.3
Tzavaras, N.4
Gupta, A.5
Neves, S.6
Battini, L.7
Gusella, G.L.8
Lachmann, A.9
Ma'ayan, A.10
Blitzer, R.D.11
Devi, L.A.12
-
90
-
-
33745085564
-
Mu opioid and CB1 cannabinoid receptor interactions: Reciprocal inhibition of receptor signaling and neuritogenesis
-
Rios, C.; Gomes, I.; Devi, L. A. mu opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis Br. J. Pharmacol. 2006, 148, 387-395
-
(2006)
Br. J. Pharmacol.
, vol.148
, pp. 387-395
-
-
Rios, C.1
Gomes, I.2
Devi, L.A.3
-
91
-
-
60549111230
-
Induced association of mu opioid (MOP) and type 2 cholecystokinin (CCK2) receptors by novel bivalent ligands
-
Zheng, Y.; Akgun, E.; Harikumar, K. G.; Hopson, J.; Powers, M. D.; Lunzer, M. M.; Miller, L. J.; Portoghese, P. S. Induced association of mu opioid (MOP) and type 2 cholecystokinin (CCK2) receptors by novel bivalent ligands J. Med. Chem. 2009, 52, 247-258
-
(2009)
J. Med. Chem.
, vol.52
, pp. 247-258
-
-
Zheng, Y.1
Akgun, E.2
Harikumar, K.G.3
Hopson, J.4
Powers, M.D.5
Lunzer, M.M.6
Miller, L.J.7
Portoghese, P.S.8
-
92
-
-
13444274883
-
Evidence for negative binding cooperativity within CCR5-CCR2b heterodimers
-
El-Asmar, L.; Springael, J. Y.; Ballet, S.; Andrieu, E. U.; Vassart, G.; Parmentier, M. Evidence for negative binding cooperativity within CCR5-CCR2b heterodimers Mol. Pharmacol. 2005, 67, 460-469
-
(2005)
Mol. Pharmacol.
, vol.67
, pp. 460-469
-
-
El-Asmar, L.1
Springael, J.Y.2
Ballet, S.3
Andrieu, E.U.4
Vassart, G.5
Parmentier, M.6
-
93
-
-
0346056873
-
Heterodimerization and cross-desensitization between the mu-opioid receptor and the chemokine CCR5 receptor
-
Chen, C. G.; Li, J.; Bot, G.; Szabo, I.; Rogers, T. J.; Liu-Chen, L. Y. Heterodimerization and cross-desensitization between the mu-opioid receptor and the chemokine CCR5 receptor Eur. J. Pharmacol. 2004, 483, 175-186
-
(2004)
Eur. J. Pharmacol.
, vol.483
, pp. 175-186
-
-
Chen, C.G.1
Li, J.2
Bot, G.3
Szabo, I.4
Rogers, T.J.5
Liu-Chen, L.Y.6
-
94
-
-
44449175613
-
CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2-DOP receptor heterodimer
-
Parenty, G.; Appelbe, S.; Milligan, G. CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2-DOP receptor heterodimer Biochem. J. 2008, 412, 245-256
-
(2008)
Biochem. J.
, vol.412
, pp. 245-256
-
-
Parenty, G.1
Appelbe, S.2
Milligan, G.3
-
95
-
-
36048947671
-
Trafficking of preassembled opioid mu-delta heterooligomer-Gz signaling complexes to the plasma membrane: Coregulation by agonists
-
Hasbi, A.; Nguyen, T.; Fan, T.; Cheng, R.; Rashid, A.; Alijaniaram, M.; Rasenick, M. M.; O'Dowd, B. F.; George, S. R. Trafficking of preassembled opioid mu-delta heterooligomer-Gz signaling complexes to the plasma membrane: coregulation by agonists Biochemistry 2007, 46, 12997-13009
-
(2007)
Biochemistry
, vol.46
, pp. 12997-13009
-
-
Hasbi, A.1
Nguyen, T.2
Fan, T.3
Cheng, R.4
Rashid, A.5
Alijaniaram, M.6
Rasenick, M.M.7
O'Dowd, B.F.8
George, S.R.9
-
96
-
-
0034714335
-
Oligomerization of mu- and delta-opioid receptors - Generation of novel functional properties
-
George, S. R.; Fan, T.; Xie, Z. D.; Tse, R.; Tam, V.; Varghese, G.; O'Dowd, B. F. Oligomerization of mu- and delta-opioid receptors-generation of novel functional properties J. Biol. Chem. 2000, 275, 26128-26135
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 26128-26135
-
-
George, S.R.1
Fan, T.2
Xie, Z.D.3
Tse, R.4
Tam, V.5
Varghese, G.6
O'Dowd, B.F.7
-
97
-
-
79956317677
-
G protein-coupled receptor heteromerization: A role in allosteric modulation of ligand binding
-
Gomes, I.; IJzerman, A. P.; Ye, K.; Maillet, E. L.; Devi, L. A. G protein-coupled receptor heteromerization: a role in allosteric modulation of ligand binding Mol. Pharmacol. 2011, 79, 1044-1052
-
(2011)
Mol. Pharmacol.
, vol.79
, pp. 1044-1052
-
-
Gomes, I.1
Ijzerman, A.P.2
Ye, K.3
Maillet, E.L.4
Devi, L.A.5
-
98
-
-
84871686505
-
Novel screening assay for the selective detection of G-protein-coupled receptor heteromer signaling
-
van Rijn, R. M.; Harvey, J. H.; Brissett, D. I.; DeFriel, J. N.; Whistler, J. L. Novel screening assay for the selective detection of G-protein-coupled receptor heteromer signaling J. Pharmacol. Exp. Ther. 2013, 344, 179-188
-
(2013)
J. Pharmacol. Exp. Ther.
, vol.344
, pp. 179-188
-
-
Van Rijn, R.M.1
Harvey, J.H.2
Brissett, D.I.3
Defriel, J.N.4
Whistler, J.L.5
-
99
-
-
23944467820
-
D1 and D2 dopamine receptors form heterooligomers and cointernalize after selective activation of either receptor
-
So, C. H.; Varghese, G.; Curley, K. J.; Kong, M. M.; Alijaniaram, M.; Ji, X.; Nguyen, T.; O'Dowd, B, F.; George, S. R. D1 and D2 dopamine receptors form heterooligomers and cointernalize after selective activation of either receptor Mol. Pharmacol. 2005, 68, 568-578
-
(2005)
Mol. Pharmacol.
, vol.68
, pp. 568-578
-
-
So, C.H.1
Varghese, G.2
Curley, K.J.3
Kong, M.M.4
Alijaniaram, M.5
Ji, X.6
Nguyen, T.7
O'Dowd, B.F.8
George, S.R.9
-
100
-
-
54449099573
-
Identification of dopamine D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum
-
Marcellino, D.; Ferre, S.; Casado, V.; Cortes, A.; Le Foll, B.; Mazzola, C.; Drago, F.; Saur, O.; Stark, H.; Soriano, A.; Barnes, C.; Goldberg, S. R.; Lluis, C.; Fuxe, K.; Franco, R. Identification of dopamine D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum J. Biol. Chem. 2008, 283, 26016-26025
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 26016-26025
-
-
Marcellino, D.1
Ferre, S.2
Casado, V.3
Cortes, A.4
Le Foll, B.5
Mazzola, C.6
Drago, F.7
Saur, O.8
Stark, H.9
Soriano, A.10
Barnes, C.11
Goldberg, S.R.12
Lluis, C.13
Fuxe, K.14
Franco, R.15
-
101
-
-
45649085857
-
Reciprocal regulation of dopamine D1 and D3 receptor function and trafficking by heterodimerization
-
Fiorentini, C.; Busi, C.; Gorruso, E.; Gotti, C.; Spano, P.; Missale, C. Reciprocal regulation of dopamine D1 and D3 receptor function and trafficking by heterodimerization Mol. Pharmacol. 2008, 74, 59-69
-
(2008)
Mol. Pharmacol.
, vol.74
, pp. 59-69
-
-
Fiorentini, C.1
Busi, C.2
Gorruso, E.3
Gotti, C.4
Spano, P.5
Missale, C.6
-
102
-
-
47349118854
-
Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function
-
Ferrada, C.; Ferre, S.; Casado, V.; Cortes, A.; Justinova, Z.; Barnes, C.; Canela, E. I.; Goldberg, S. R.; Leurs, R.; Lluis, C.; Franco, R. Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function Neuropharmacology 2008, 55, 190-197
-
(2008)
Neuropharmacology
, vol.55
, pp. 190-197
-
-
Ferrada, C.1
Ferre, S.2
Casado, V.3
Cortes, A.4
Justinova, Z.5
Barnes, C.6
Canela, E.I.7
Goldberg, S.R.8
Leurs, R.9
Lluis, C.10
Franco, R.11
-
103
-
-
0035839599
-
D2/D3 dopamine receptor heterodimers exhibit unique functional properties
-
Scarselli, M.; Novi, F.; Schallmach, E.; Lin, R.; Baragli, A.; Colzi, A.; Griffon, N.; Corsini, G. U.; Sokoloff, P.; Levenson, R.; Vogel, Z.; Maggio, R. D2/D3 dopamine receptor heterodimers exhibit unique functional properties J. Biol. Chem. 2001, 276, 30308-30314
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 30308-30314
-
-
Scarselli, M.1
Novi, F.2
Schallmach, E.3
Lin, R.4
Baragli, A.5
Colzi, A.6
Griffon, N.7
Corsini, G.U.8
Sokoloff, P.9
Levenson, R.10
Vogel, Z.11
Maggio, R.12
-
104
-
-
0142241355
-
Potent activation of dopamine D3/D2 heterodimers by the antiparkinsonian agents, S32504, pramipexole and ropinirole
-
Maggio, R.; Scarselli, M.; Novi, F.; Millan, M. J.; Corsini, G. U. Potent activation of dopamine D3/D2 heterodimers by the antiparkinsonian agents, S32504, pramipexole and ropinirole J. Neurochem. 2003, 87, 631-641
-
(2003)
J. Neurochem.
, vol.87
, pp. 631-641
-
-
Maggio, R.1
Scarselli, M.2
Novi, F.3
Millan, M.J.4
Corsini, G.U.5
-
105
-
-
0034616021
-
Receptors for dopamine and somatostatin: Formation of hetero-oligomers with enhanced functional activity
-
Rocheville, M.; Lange, D. C.; Kumar, U.; Patel, S. C.; Patel, R. C.; Patel, Y. C. Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity Science 2000, 288, 154-157
-
(2000)
Science
, vol.288
, pp. 154-157
-
-
Rocheville, M.1
Lange, D.C.2
Kumar, U.3
Patel, S.C.4
Patel, R.C.5
Patel, Y.C.6
-
106
-
-
21144439867
-
Opioid receptor homo- and heterodimerization in living cells by quantitative bioluminescence resonance energy transfer
-
Wang, D.; Sun, X.; Bohn, L. M.; Sadee, W. Opioid receptor homo- and heterodimerization in living cells by quantitative bioluminescence resonance energy transfer Mol. Pharmacol. 2005, 67, 2173-2184
-
(2005)
Mol. Pharmacol.
, vol.67
, pp. 2173-2184
-
-
Wang, D.1
Sun, X.2
Bohn, L.M.3
Sadee, W.4
-
107
-
-
0037205489
-
Heterodimerization of somatostatin and opioid receptors cross-modulates phosphorylation, internalization, and desensitization
-
Pfeiffer, M.; Koch, T.; Schroder, H.; Laugsch, M.; Hollt, V.; Schulz, S. Heterodimerization of somatostatin and opioid receptors cross-modulates phosphorylation, internalization, and desensitization J. Biol. Chem. 2002, 277, 19762-19772
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 19762-19772
-
-
Pfeiffer, M.1
Koch, T.2
Schroder, H.3
Laugsch, M.4
Hollt, V.5
Schulz, S.6
-
108
-
-
84863045698
-
Structural aspects of M(3) muscarinic acetylcholine receptor dimer formation and activation
-
Hu, J.; Thor, D.; Zhou, Y.; Liu, T.; Wang, Y.; McMillin, S. M.; Mistry, R.; Challiss, R. A.; Costanzi, S.; Wess, J. Structural aspects of M(3) muscarinic acetylcholine receptor dimer formation and activation FASEB J. 2012, 26, 604-616
-
(2012)
FASEB J.
, vol.26
, pp. 604-616
-
-
Hu, J.1
Thor, D.2
Zhou, Y.3
Liu, T.4
Wang, Y.5
McMillin, S.M.6
Mistry, R.7
Challiss, R.A.8
Costanzi, S.9
Wess, J.10
-
109
-
-
0034677745
-
Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers
-
Rocheville, M.; Lange, D. C.; Kumar, U.; Sasi, R.; Patel, R. C.; Patel, Y. C. Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers J. Biol. Chem. 2000, 275, 7862-7869
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 7862-7869
-
-
Rocheville, M.1
Lange, D.C.2
Kumar, U.3
Sasi, R.4
Patel, R.C.5
Patel, Y.C.6
-
110
-
-
0035958027
-
Homo- and heterodimerization of somatostatin receptor subtypes. Inactivation of sst(3) receptor function by heterodimerization with sst(2A)
-
Pfeiffer, M.; Koch, T.; Schroder, H.; Klutzny, M.; Kirscht, S.; Kreienkamp, H. J.; Hollt, V.; Schulz, S. Homo- and heterodimerization of somatostatin receptor subtypes. Inactivation of sst(3) receptor function by heterodimerization with sst(2A) J. Biol. Chem. 2001, 276, 14027-14036
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 14027-14036
-
-
Pfeiffer, M.1
Koch, T.2
Schroder, H.3
Klutzny, M.4
Kirscht, S.5
Kreienkamp, H.J.6
Hollt, V.7
Schulz, S.8
-
111
-
-
1242274647
-
Heterodimerization of V1a and V2 vasopressin receptors determines the interaction with beta-arrestin and their trafficking patterns
-
Terrillon, S.; Barberis, C.; Bouvier, M. Heterodimerization of V1a and V2 vasopressin receptors determines the interaction with beta-arrestin and their trafficking patterns Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 1548-1553
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 1548-1553
-
-
Terrillon, S.1
Barberis, C.2
Bouvier, M.3
-
112
-
-
0037384043
-
Oxytocin and vasopressin V1a and V2 receptors form constitutive homo- and heterodimers during biosynthesis
-
Terrillon, S.; Durroux, T.; Mouillac, B.; Breit, A.; Ayoub, M. A.; Taulan, M.; Jockers, R.; Barberis, C.; Bouvier, M. Oxytocin and vasopressin V1a and V2 receptors form constitutive homo- and heterodimers during biosynthesis Mol. Endocrinol. 2003, 17, 677-691
-
(2003)
Mol. Endocrinol.
, vol.17
, pp. 677-691
-
-
Terrillon, S.1
Durroux, T.2
Mouillac, B.3
Breit, A.4
Ayoub, M.A.5
Taulan, M.6
Jockers, R.7
Barberis, C.8
Bouvier, M.9
-
113
-
-
78650003293
-
Uncoupling the dopamine D1-D2 receptor complex exerts antidepressant-like effects
-
Pei, L.; Li, S.; Wang, M.; Diwan, M.; Anisman, H.; Fletcher, P. J.; Nobrega, J. N.; Liu, F. Uncoupling the dopamine D1-D2 receptor complex exerts antidepressant-like effects Nat. Med. 2010, 16, 1393-1395
-
(2010)
Nat. Med.
, vol.16
, pp. 1393-1395
-
-
Pei, L.1
Li, S.2
Wang, M.3
Diwan, M.4
Anisman, H.5
Fletcher, P.J.6
Nobrega, J.N.7
Liu, F.8
-
114
-
-
33646430867
-
Receptor heterodimerization: A new level of cross-talk
-
Barnes, P. J. Receptor heterodimerization: a new level of cross-talk J. Clin. Invest. 2006, 116, 1210-1212
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 1210-1212
-
-
Barnes, P.J.1
-
115
-
-
30044442319
-
Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series
-
Daniels, D. J.; Lenard, N. R.; Etienne, C. L.; Law, P. Y.; Roerig, S. C.; Portoghese, P. S. Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 19208-19213
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 19208-19213
-
-
Daniels, D.J.1
Lenard, N.R.2
Etienne, C.L.3
Law, P.Y.4
Roerig, S.C.5
Portoghese, P.S.6
-
116
-
-
34249080643
-
Absence of conditioned place preference or reinstatement with bivalent ligands containing mu-opioid receptor agonist and delta-opioid receptor antagonist pharmacophores
-
Lenard, N. R.; Daniels, D. J.; Portoghese, P. S.; Roerig, S. C. Absence of conditioned place preference or reinstatement with bivalent ligands containing mu-opioid receptor agonist and delta-opioid receptor antagonist pharmacophores Eur. J. Pharmacol. 2007, 566, 75-82
-
(2007)
Eur. J. Pharmacol.
, vol.566
, pp. 75-82
-
-
Lenard, N.R.1
Daniels, D.J.2
Portoghese, P.S.3
Roerig, S.C.4
-
117
-
-
84866370991
-
Synergism between a serotonin 5-HT2A receptor (5-HT2AR) antagonist and 5-HT2CR agonist suggests new pharmacotherapeutics for cocaine addiction
-
Cunningham, K. A.; Anastasio, N. C.; Fox, R. G.; Stutz, S. J.; Bubar, M. J.; Swinford, S. E.; Watson, C. S.; Gilbertson, S. R.; Rice, K. C.; Rosenzweig-Lipson, S.; Moeller, F. G. Synergism between a serotonin 5-HT2A receptor (5-HT2AR) antagonist and 5-HT2CR agonist suggests new pharmacotherapeutics for cocaine addiction ACS Chem. Neurosci. 2013, 4, 110-121
-
(2013)
ACS Chem. Neurosci.
, vol.4
, pp. 110-121
-
-
Cunningham, K.A.1
Anastasio, N.C.2
Fox, R.G.3
Stutz, S.J.4
Bubar, M.J.5
Swinford, S.E.6
Watson, C.S.7
Gilbertson, S.R.8
Rice, K.C.9
Rosenzweig-Lipson, S.10
Moeller, F.G.11
-
118
-
-
21144446486
-
A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers
-
Waldhoer, M.; Fong, J.; Jones, R. M.; Lunzer, M. M.; Sharma, S. K.; Kostenis, E.; Portoghese, P. S.; Whistler, J. L. A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 9050-9055
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 9050-9055
-
-
Waldhoer, M.1
Fong, J.2
Jones, R.M.3
Lunzer, M.M.4
Sharma, S.K.5
Kostenis, E.6
Portoghese, P.S.7
Whistler, J.L.8
-
119
-
-
79953191134
-
N -Naphthoyl-beta-naltrexamine (NNTA), a highly selective and potent activator of mu/kappa-opioid heteromers
-
Yekkirala, A. S.; Lunzer, M. M.; McCurdy, C. R.; Powers, M. D.; Kalyuzhny, A. E.; Roerig, S. C.; Portoghese, P. S. N -Naphthoyl-beta- naltrexamine (NNTA), a highly selective and potent activator of mu/kappa-opioid heteromers Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 5098-5103
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 5098-5103
-
-
Yekkirala, A.S.1
Lunzer, M.M.2
McCurdy, C.R.3
Powers, M.D.4
Kalyuzhny, A.E.5
Roerig, S.C.6
Portoghese, P.S.7
-
120
-
-
84866405449
-
Clinically employed opioid analgesics produce antinociception via mu-delta opioid receptor heteromers in Rhesus monkeys
-
Yekkirala, A. S.; Banks, M. L.; Lunzer, M. M.; Negus, S. S.; Rice, K. C.; Portoghese, P. S. Clinically employed opioid analgesics produce antinociception via mu-delta opioid receptor heteromers in Rhesus monkeys ACS Chem. Neurosci. 2012, 3, 720-727
-
(2012)
ACS Chem. Neurosci.
, vol.3
, pp. 720-727
-
-
Yekkirala, A.S.1
Banks, M.L.2
Lunzer, M.M.3
Negus, S.S.4
Rice, K.C.5
Portoghese, P.S.6
-
121
-
-
81555228201
-
Development of a bivalent dopamine D2 receptor agonist
-
Kuhhorn, J.; Gotz, A.; Hubner, H.; Thompson, D.; Whistler, J.; Gmeiner, P. Development of a bivalent dopamine D2 receptor agonist J. Med. Chem. 2011, 54, 7911-7919
-
(2011)
J. Med. Chem.
, vol.54
, pp. 7911-7919
-
-
Kuhhorn, J.1
Gotz, A.2
Hubner, H.3
Thompson, D.4
Whistler, J.5
Gmeiner, P.6
-
122
-
-
0019990819
-
Narcotic antagonistic potency of bivalent ligands which contain beta-naltrexamine. Evidence for bridging between proximal recognition sites
-
Erez, M.; Takemori, A. E.; Portoghese, P. S. Narcotic antagonistic potency of bivalent ligands which contain beta-naltrexamine. Evidence for bridging between proximal recognition sites J. Med. Chem. 1982, 25, 847-849
-
(1982)
J. Med. Chem.
, vol.25
, pp. 847-849
-
-
Erez, M.1
Takemori, A.E.2
Portoghese, P.S.3
-
123
-
-
0020451569
-
Opioid agonist and antagonist bivalent ligands as receptor probes
-
Portoghese, P. S.; Ronsisvalle, G.; Larson, D. L.; Yim, C. B.; Sayre, L. M.; Takemori, A. E. Opioid agonist and antagonist bivalent ligands as receptor probes Life Sci. 1982, 31, 1283-1286
-
(1982)
Life Sci.
, vol.31
, pp. 1283-1286
-
-
Portoghese, P.S.1
Ronsisvalle, G.2
Larson, D.L.3
Yim, C.B.4
Sayre, L.M.5
Takemori, A.E.6
-
124
-
-
0022251438
-
Stereostructure-activity relationship of opioid agonist and antagonist bivalent ligands. Evidence for bridging between vicinal opioid receptors
-
Portoghese, P. S.; Larson, D. L.; Yim, C. B.; Sayre, L. M.; Ronsisvalle, G.; Lipkowski, A. W.; Takemori, A. E.; Rice, K. C.; Tam, S. W. Stereostructure-activity relationship of opioid agonist and antagonist bivalent ligands. Evidence for bridging between vicinal opioid receptors J. Med. Chem. 1985, 28, 1140-1141
-
(1985)
J. Med. Chem.
, vol.28
, pp. 1140-1141
-
-
Portoghese, P.S.1
Larson, D.L.2
Yim, C.B.3
Sayre, L.M.4
Ronsisvalle, G.5
Lipkowski, A.W.6
Takemori, A.E.7
Rice, K.C.8
Tam, S.W.9
-
125
-
-
0022902748
-
Opioid agonist and antagonist bivalent ligands. The relationship between spacer length and selectivity at multiple opioid receptors
-
Portoghese, P. S.; Larson, D. L.; Sayre, L. M.; Yim, C. B.; Ronsisvalle, G.; Tam, S. W.; Takemori, A. E. Opioid agonist and antagonist bivalent ligands. The relationship between spacer length and selectivity at multiple opioid receptors J. Med. Chem. 1986, 29, 1855-1861
-
(1986)
J. Med. Chem.
, vol.29
, pp. 1855-1861
-
-
Portoghese, P.S.1
Larson, D.L.2
Sayre, L.M.3
Yim, C.B.4
Ronsisvalle, G.5
Tam, S.W.6
Takemori, A.E.7
-
126
-
-
10544224535
-
Serotonin dimers: Application of the bivalent ligand approach to the design of new potent and selective 5-HT(1B/1D) agonists
-
Halazy, S.; Perez, M.; Fourrier, C.; Pallard, I.; Pauwels, P. J.; Palmier, C.; John, G. W.; Valentin, J. P.; Bonnafous, R.; Martinez, J. Serotonin dimers: application of the bivalent ligand approach to the design of new potent and selective 5-HT(1B/1D) agonists J. Med. Chem. 1996, 39, 4920-4927
-
(1996)
J. Med. Chem.
, vol.39
, pp. 4920-4927
-
-
Halazy, S.1
Perez, M.2
Fourrier, C.3
Pallard, I.4
Pauwels, P.J.5
Palmier, C.6
John, G.W.7
Valentin, J.P.8
Bonnafous, R.9
Martinez, J.10
-
127
-
-
0032539780
-
Dimerization of sumatriptan as an efficient way to design a potent, centrally and orally active 5-HT1B agonist
-
Perez, M.; Pauwels, P. J.; Fourrier, C.; Chopin, P.; Valentin, J. P.; John, G. W.; Marien, M.; Halazy, S. Dimerization of sumatriptan as an efficient way to design a potent, centrally and orally active 5-HT1B agonist Bioorg. Med. Chem. Lett. 1998, 8, 675-680
-
(1998)
Bioorg. Med. Chem. Lett.
, vol.8
, pp. 675-680
-
-
Perez, M.1
Pauwels, P.J.2
Fourrier, C.3
Chopin, P.4
Valentin, J.P.5
John, G.W.6
Marien, M.7
Halazy, S.8
-
128
-
-
34548487956
-
Synthesis of specific bivalent probes that functionally interact with 5-HT4 receptor dimers
-
Russo, O.; Berthouze, M.; Giner, M.; Soulier, J. L.; Rivail, L.; Sicsic, S.; Lezoualc'h, F.; Jockers, R.; Berque-Bestel, I. Synthesis of specific bivalent probes that functionally interact with 5-HT4 receptor dimers J. Med. Chem. 2007, 50, 4482-4492
-
(2007)
J. Med. Chem.
, vol.50
, pp. 4482-4492
-
-
Russo, O.1
Berthouze, M.2
Giner, M.3
Soulier, J.L.4
Rivail, L.5
Sicsic, S.6
Lezoualc'H, F.7
Jockers, R.8
Berque-Bestel, I.9
-
129
-
-
26444449975
-
Design and synthesis of specific probes for human 5-HT4 receptor dimerization studies
-
Soulier, J. L.; Russo, O.; Giner, M.; Rivail, L.; Berthouze, M.; Ongeri, S.; Maigret, B.; Fischmeister, R.; Lezoualc'h, F.; Sicsic, S.; Berque-Bestel, I. Design and synthesis of specific probes for human 5-HT4 receptor dimerization studies J. Med. Chem. 2005, 48, 6220-6228
-
(2005)
J. Med. Chem.
, vol.48
, pp. 6220-6228
-
-
Soulier, J.L.1
Russo, O.2
Giner, M.3
Rivail, L.4
Berthouze, M.5
Ongeri, S.6
Maigret, B.7
Fischmeister, R.8
Lezoualc'H, F.9
Sicsic, S.10
Berque-Bestel, I.11
-
130
-
-
84856837790
-
The bivalent ligand approach leads to highly potent and selective acylguanidine-type histamine H2 receptor agonists
-
Birnkammer, T.; Spickenreither, A.; Brunskole, I.; Lopuch, M.; Kagermeier, N.; Bernhardt, G.; Dove, S.; Seifert, R.; Elz, S.; Buschauer, A. The bivalent ligand approach leads to highly potent and selective acylguanidine-type histamine H2 receptor agonists J. Med. Chem. 2012, 55, 1147-1160
-
(2012)
J. Med. Chem.
, vol.55
, pp. 1147-1160
-
-
Birnkammer, T.1
Spickenreither, A.2
Brunskole, I.3
Lopuch, M.4
Kagermeier, N.5
Bernhardt, G.6
Dove, S.7
Seifert, R.8
Elz, S.9
Buschauer, A.10
-
131
-
-
71049142202
-
1,1′-Disubstituted ferrocenes as molecular hinges in mono- and bivalent dopamine receptor ligands
-
Huber, D.; Hubner, H.; Gmeiner, P. 1,1′-Disubstituted ferrocenes as molecular hinges in mono- and bivalent dopamine receptor ligands J. Med. Chem. 2009, 52, 6860-6870
-
(2009)
J. Med. Chem.
, vol.52
, pp. 6860-6870
-
-
Huber, D.1
Hubner, H.2
Gmeiner, P.3
-
132
-
-
84855186679
-
Bivalent molecular probes for dopamine D2-like receptors
-
Huber, D.; Lober, S.; Hubner, H.; Gmeiner, P. Bivalent molecular probes for dopamine D2-like receptors Bioorg. Med. Chem. 2012, 20, 455-466
-
(2012)
Bioorg. Med. Chem.
, vol.20
, pp. 455-466
-
-
Huber, D.1
Lober, S.2
Hubner, H.3
Gmeiner, P.4
-
133
-
-
77953774621
-
Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors
-
Butini, S.; Campiani, G.; Franceschini, S.; Trotta, F.; Kumar, V.; Guarino, E.; Borrelli, G.; Fiorini, I.; Novellino, E.; Fattorusso, C.; Persico, M.; Orteca, N.; Sandager-Nielsen, K.; Jacobsen, T. A.; Madsen, K.; Scheel-Kruger, J.; Gemma, S. Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors J. Med. Chem. 2010, 53, 4803-4807
-
(2010)
J. Med. Chem.
, vol.53
, pp. 4803-4807
-
-
Butini, S.1
Campiani, G.2
Franceschini, S.3
Trotta, F.4
Kumar, V.5
Guarino, E.6
Borrelli, G.7
Fiorini, I.8
Novellino, E.9
Fattorusso, C.10
Persico, M.11
Orteca, N.12
Sandager-Nielsen, K.13
Jacobsen, T.A.14
Madsen, K.15
Scheel-Kruger, J.16
Gemma, S.17
-
134
-
-
79960172993
-
Bivalent dopamine D2 receptor ligands: Synthesis and binding properties
-
Kuhhorn, J.; Hubner, H.; Gmeiner, P. Bivalent dopamine D2 receptor ligands: synthesis and binding properties J. Med. Chem. 2011, 54, 4896-4903
-
(2011)
J. Med. Chem.
, vol.54
, pp. 4896-4903
-
-
Kuhhorn, J.1
Hubner, H.2
Gmeiner, P.3
-
135
-
-
84857430512
-
Homobivalent ligands of the atypical antipsychotic clozapine: Design, synthesis, and pharmacological evaluation
-
McRobb, F. M.; Crosby, I. T.; Yuriev, E.; Lane, J. R.; Capuano, B. Homobivalent ligands of the atypical antipsychotic clozapine: design, synthesis, and pharmacological evaluation J. Med. Chem. 2012, 55, 1622-1634
-
(2012)
J. Med. Chem.
, vol.55
, pp. 1622-1634
-
-
McRobb, F.M.1
Crosby, I.T.2
Yuriev, E.3
Lane, J.R.4
Capuano, B.5
-
136
-
-
84871255186
-
Novel bivalent ligands for D2/D3 dopamine receptors: Significant co-operative gain in D2 affinity and potency
-
Gogoi, S.; Biswas, S.; Modi, G.; Antonio, T.; Reith, M. E.; Dutta, A. K. Novel bivalent ligands for D2/D3 dopamine receptors: significant co-operative gain in D2 affinity and potency ACS Med. Chem. Lett. 2012, 3, 991-996
-
(2012)
ACS Med. Chem. Lett.
, vol.3
, pp. 991-996
-
-
Gogoi, S.1
Biswas, S.2
Modi, G.3
Antonio, T.4
Reith, M.E.5
Dutta, A.K.6
-
137
-
-
70349192980
-
Adenosine A2A receptor-antagonist/dopamine D2 receptor-agonist bivalent ligands as pharmacological tools to detect A2A-D2 receptor heteromers
-
Soriano, A.; Ventura, R.; Molero, A.; Hoen, R.; Casado, V.; Cortes, A.; Fanelli, F.; Albericio, F.; Lluis, C.; Franco, R.; Royo, M. Adenosine A2A receptor-antagonist/dopamine D2 receptor-agonist bivalent ligands as pharmacological tools to detect A2A-D2 receptor heteromers J. Med. Chem. 2009, 52, 5590-5602
-
(2009)
J. Med. Chem.
, vol.52
, pp. 5590-5602
-
-
Soriano, A.1
Ventura, R.2
Molero, A.3
Hoen, R.4
Casado, V.5
Cortes, A.6
Fanelli, F.7
Albericio, F.8
Lluis, C.9
Franco, R.10
Royo, M.11
-
138
-
-
0034730498
-
A novel pharmacological approach to treating cardiac ischemia. Binary conjugates of A1 and A3 adenosine receptor agonists
-
Jacobson, K. A.; Xie, R.; Young, L.; Chang, L.; Liang, B. T. A novel pharmacological approach to treating cardiac ischemia. Binary conjugates of A1 and A3 adenosine receptor agonists J. Biol. Chem. 2000, 275, 30272-30279
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 30272-30279
-
-
Jacobson, K.A.1
Xie, R.2
Young, L.3
Chang, L.4
Liang, B.T.5
-
139
-
-
78449262856
-
Bivalent ligands of CXCR4 with rigid linkers for elucidation of the dimerization state in cells
-
Tanaka, T.; Nomura, W.; Narumi, T.; Masuda, A.; Tamamura, H. Bivalent ligands of CXCR4 with rigid linkers for elucidation of the dimerization state in cells J. Am. Chem. Soc. 2010, 132, 15899-15901
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 15899-15901
-
-
Tanaka, T.1
Nomura, W.2
Narumi, T.3
Masuda, A.4
Tamamura, H.5
-
140
-
-
84866065396
-
A novel synthetic bivalent ligand to probe chemokine receptor CXCR4 dimerization and inhibit HIV-1 entry
-
Choi, W. T.; Kumar, S.; Madani, N.; Han, X.; Tian, S.; Dong, C. Z.; Liu, D.; Duggineni, S.; Yuan, J.; Sodroski, J. G.; Huang, Z.; An, J. A novel synthetic bivalent ligand to probe chemokine receptor CXCR4 dimerization and inhibit HIV-1 entry Biochemistry 2012, 51, 7078-7086
-
(2012)
Biochemistry
, vol.51
, pp. 7078-7086
-
-
Choi, W.T.1
Kumar, S.2
Madani, N.3
Han, X.4
Tian, S.5
Dong, C.Z.6
Liu, D.7
Duggineni, S.8
Yuan, J.9
Sodroski, J.G.10
Huang, Z.11
An, J.12
-
141
-
-
77957908601
-
Synthesis and biological evaluation of bivalent ligands for the cannabinoid 1 receptor
-
Zhang, Y. N.; Gilliam, A.; Maitra, R.; Damaj, M. I.; Tajuba, J. M.; Seltzman, H. H.; Thomas, B. F. Synthesis and biological evaluation of bivalent ligands for the cannabinoid 1 receptor J. Med. Chem. 2010, 53, 7048-7060
-
(2010)
J. Med. Chem.
, vol.53
, pp. 7048-7060
-
-
Zhang, Y.N.1
Gilliam, A.2
Maitra, R.3
Damaj, M.I.4
Tajuba, J.M.5
Seltzman, H.H.6
Thomas, B.F.7
-
142
-
-
0035924177
-
Design, synthesis, and biological characterization of bivalent 1-methyl-1,2,5,6-tetrahydropyridyl-1,2,5-thiadiazole derivatives as selective muscarinic agonists
-
Rajeswaran, W. G.; Cao, Y.; Huang, X. P.; Wroblewski, M. E.; Colclough, T.; Lee, S.; Liu, F.; Nagy, P. I.; Ellis, J.; Levine, B. A.; Nocka, K. H.; Messer, W. S., Jr. Design, synthesis, and biological characterization of bivalent 1-methyl-1,2,5,6-tetrahydropyridyl-1,2,5-thiadiazole derivatives as
-
(2001)
J. Med. Chem.
, vol.44
, pp. 4563-4576
-
-
Rajeswaran, W.G.1
Cao, Y.2
Huang, X.P.3
Wroblewski, M.E.4
Colclough, T.5
Lee, S.6
Liu, F.7
Nagy, P.I.8
Ellis, J.9
Levine, B.A.10
Nocka, K.H.11
Messer Jr., W.S.12
-
143
-
-
0141680849
-
Synthesis and biological characterization of 1-methyl-1,2,5,6- tetrahydropyridyl-1,2,5-thiadiazole derivatives as muscarinic agonists for the treatment of neurological disorders
-
Cao, Y.; Zhang, M.; Wu, C.; Lee, S.; Wroblewski, M. E.; Whipple, T.; Nagy, P. I.; Takacs-Novak, K.; Balazs, A.; Toros, S.; Messer, W. S., Jr. Synthesis and biological characterization of 1-methyl-1,2,5,6-tetrahydropyridyl- 1,2,5-thiadiazole derivatives as muscarinic agonists for the treatment of neurological disorders J. Med. Chem. 2003, 46, 4273-4286
-
(2003)
J. Med. Chem.
, vol.46
, pp. 4273-4286
-
-
Cao, Y.1
Zhang, M.2
Wu, C.3
Lee, S.4
Wroblewski, M.E.5
Whipple, T.6
Nagy, P.I.7
Takacs-Novak, K.8
Balazs, A.9
Toros, S.10
Messer Jr., W.S.11
-
144
-
-
53549115957
-
Synthesis of bivalent beta2-adrenergic and adenosine A1 receptor ligands
-
Karellas, P.; McNaughton, M.; Baker, S. P.; Scammells, P. J. Synthesis of bivalent beta2-adrenergic and adenosine A1 receptor ligands J. Med. Chem. 2008, 51, 6128-6137
-
(2008)
J. Med. Chem.
, vol.51
, pp. 6128-6137
-
-
Karellas, P.1
McNaughton, M.2
Baker, S.P.3
Scammells, P.J.4
-
145
-
-
0036894983
-
Yohimbine dimers exhibiting selectivity for the human alpha 2C-adrenoceptor subtype
-
Lalchandani, S. G.; Lei, L.; Zheng, W.; Suni, M. M.; Moore, B. M.; Liggett, S. B.; Miller, D. D.; Feller, D. R. Yohimbine dimers exhibiting selectivity for the human alpha 2C-adrenoceptor subtype J. Pharmacol. Exp. Ther. 2002, 303, 979-984
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.303
, pp. 979-984
-
-
Lalchandani, S.G.1
Lei, L.2
Zheng, W.3
Suni, M.M.4
Moore, B.M.5
Liggett, S.B.6
Miller, D.D.7
Feller, D.R.8
-
146
-
-
67650489125
-
Orthosteric/allosteric bitopic ligands: Going hybrid at GPCRs
-
Valant, C.; Sexton, P. M.; Christopoulos, A. Orthosteric/allosteric bitopic ligands: going hybrid at GPCRs Mol. Interventions 2009, 9, 125-135
-
(2009)
Mol. Interventions
, vol.9
, pp. 125-135
-
-
Valant, C.1
Sexton, P.M.2
Christopoulos, A.3
-
147
-
-
77949409939
-
Rational design of dualsteric GPCR ligands: Quests and promise
-
Mohr, K.; Trankle, C.; Kostenis, E.; Barocelli, E.; De Amici, M.; Holzgrabe, U. Rational design of dualsteric GPCR ligands: quests and promise Br. J. Pharmacol. 2010, 159, 997-1008
-
(2010)
Br. J. Pharmacol.
, vol.159
, pp. 997-1008
-
-
Mohr, K.1
Trankle, C.2
Kostenis, E.3
Barocelli, E.4
De Amici, M.5
Holzgrabe, U.6
-
148
-
-
84855879360
-
The best of both worlds? Bitopic orthosteric/allosteric ligands of g protein-coupled receptors
-
Valant, C.; Robert Lane, J.; Sexton, P. M.; Christopoulos, A. The best of both worlds? Bitopic orthosteric/allosteric ligands of g protein-coupled receptors Annu. Rev. Pharmacol. Toxicol. 2012, 52, 153-178
-
(2012)
Annu. Rev. Pharmacol. Toxicol.
, vol.52
, pp. 153-178
-
-
Valant, C.1
Robert Lane, J.2
Sexton, P.M.3
Christopoulos, A.4
-
149
-
-
79957596498
-
Design strategies for bivalent ligands targeting GPCRs
-
Shonberg, J.; Scammells, P. J.; Capuano, B. Design strategies for bivalent ligands targeting GPCRs ChemMedChem. 2011, 6, 963-974
-
(2011)
ChemMedChem.
, vol.6
, pp. 963-974
-
-
Shonberg, J.1
Scammells, P.J.2
Capuano, B.3
-
150
-
-
72249095188
-
Univalent and bivalent ligands of butorphan: Characteristics of the linking chain determine the affinity and potency of such opioid ligands
-
Decker, M.; Fulton, B. S.; Zhang, B.; Knapp, B. I.; Bidlack, J. M.; Neumeyer, J. L. Univalent and bivalent ligands of butorphan: characteristics of the linking chain determine the affinity and potency of such opioid ligands J. Med. Chem. 2009, 52, 7389-7396
-
(2009)
J. Med. Chem.
, vol.52
, pp. 7389-7396
-
-
Decker, M.1
Fulton, B.S.2
Zhang, B.3
Knapp, B.I.4
Bidlack, J.M.5
Neumeyer, J.L.6
-
151
-
-
79955473227
-
Synthesis and binding affinity of novel mono- and bivalent morphinan ligands for kappa, mu, and delta opioid receptors
-
Zhang, B.; Zhang, T.; Sromek, A. W.; Scrimale, T.; Bidlack, J. M.; Neumeyer, J. L. Synthesis and binding affinity of novel mono- and bivalent morphinan ligands for kappa, mu, and delta opioid receptors Bioorg. Med. Chem. 2011, 19, 2808-2816
-
(2011)
Bioorg. Med. Chem.
, vol.19
, pp. 2808-2816
-
-
Zhang, B.1
Zhang, T.2
Sromek, A.W.3
Scrimale, T.4
Bidlack, J.M.5
Neumeyer, J.L.6
-
152
-
-
41649108197
-
Synthesis and evaluation of homodimeric GnRHR antagonists having a rigid bis-propargylated benzene core
-
Bonger, K. M.; van den Berg, R. J.; Knijnenburg, A. D.; Heitman, L. H.; Ijzerman, A. P.; Oosterom, J.; Timmers, C. M.; Overkleeft, H. S.; van der Marel, G. A. Synthesis and evaluation of homodimeric GnRHR antagonists having a rigid bis-propargylated benzene core Bioorg. Med. Chem. 2008, 16, 3744-3758
-
(2008)
Bioorg. Med. Chem.
, vol.16
, pp. 3744-3758
-
-
Bonger, K.M.1
Van Den Berg, R.J.2
Knijnenburg, A.D.3
Heitman, L.H.4
Ijzerman, A.P.5
Oosterom, J.6
Timmers, C.M.7
Overkleeft, H.S.8
Van Der Marel, G.A.9
-
153
-
-
54849406536
-
Modular synthesis of non-peptidic bivalent NPY Y1 receptor antagonists
-
Weiss, S.; Keller, M.; Bernhardt, G.; Buschauer, A.; Konig, B. Modular synthesis of non-peptidic bivalent NPY Y1 receptor antagonists Bioorg. Med. Chem. 2008, 16, 9858-9866
-
(2008)
Bioorg. Med. Chem.
, vol.16
, pp. 9858-9866
-
-
Weiss, S.1
Keller, M.2
Bernhardt, G.3
Buschauer, A.4
Konig, B.5
-
154
-
-
2542625998
-
A bivalent ligand (KDN-21) reveals spinal delta and kappa opioid receptors are organized as heterodimers that give rise to delta(1) and kappa(2) phenotypes. Selective targeting of delta-kappa heterodimers
-
Bhushan, R. G.; Sharma, S. K.; Xie, Z.; Daniels, D. J.; Portoghese, P. S. A bivalent ligand (KDN-21) reveals spinal delta and kappa opioid receptors are organized as heterodimers that give rise to delta(1) and kappa(2) phenotypes. Selective targeting of delta-kappa heterodimers J. Med. Chem. 2004, 47, 2969-2972
-
(2004)
J. Med. Chem.
, vol.47
, pp. 2969-2972
-
-
Bhushan, R.G.1
Sharma, S.K.2
Xie, Z.3
Daniels, D.J.4
Portoghese, P.S.5
-
155
-
-
7044285782
-
New insights into the human 5-HT4 receptor binding site: Exploration of a hydrophobic pocket
-
Rivail, L.; Giner, M.; Gastineau, M.; Berthouze, M.; Soulier, J. L.; Fischmeister, R.; Lezoualc'h, F.; Maigret, B.; Sicsic, S.; Berque-Bestel, I. New insights into the human 5-HT4 receptor binding site: exploration of a hydrophobic pocket Br. J. Pharmacol. 2004, 143, 361-370
-
(2004)
Br. J. Pharmacol.
, vol.143
, pp. 361-370
-
-
Rivail, L.1
Giner, M.2
Gastineau, M.3
Berthouze, M.4
Soulier, J.L.5
Fischmeister, R.6
Lezoualc'H, F.7
Maigret, B.8
Sicsic, S.9
Berque-Bestel, I.10
-
156
-
-
0038454684
-
Synthesis and characterization of the first fluorescent antagonists for human 5-HT4 receptors
-
Berque-Bestel, I.; Soulier, J. L.; Giner, M.; Rivail, L.; Langlois, M.; Sicsic, S. Synthesis and characterization of the first fluorescent antagonists for human 5-HT4 receptors J. Med. Chem. 2003, 46, 2606-2620
-
(2003)
J. Med. Chem.
, vol.46
, pp. 2606-2620
-
-
Berque-Bestel, I.1
Soulier, J.L.2
Giner, M.3
Rivail, L.4
Langlois, M.5
Sicsic, S.6
-
157
-
-
71849086669
-
A bivalent ligand (KMN-21) antagonist for mu/kappa heterodimeric opioid receptors
-
Zhang, S.; Yekkirala, A.; Tang, Y.; Portoghese, P. S. A bivalent ligand (KMN-21) antagonist for mu/kappa heterodimeric opioid receptors Bioorg. Med. Chem. Lett. 2009, 19, 6978-6980
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, pp. 6978-6980
-
-
Zhang, S.1
Yekkirala, A.2
Tang, Y.3
Portoghese, P.S.4
-
158
-
-
15444364860
-
A bivalent ligand (KDAN-18) containing delta-antagonist and kappa-agonist pharmacophores bridges delta2 and kappa1 opioid receptor phenotypes
-
Daniels, D. J.; Kulkarni, A.; Xie, Z. H.; Bhushan, R. G.; Portoghese, P. S. A bivalent ligand (KDAN-18) containing delta-antagonist and kappa-agonist pharmacophores bridges delta2 and kappa1 opioid receptor phenotypes J. Med. Chem. 2005, 48, 1713-1716
-
(2005)
J. Med. Chem.
, vol.48
, pp. 1713-1716
-
-
Daniels, D.J.1
Kulkarni, A.2
Xie, Z.H.3
Bhushan, R.G.4
Portoghese, P.S.5
-
159
-
-
0022922731
-
Synthesis and opioid antagonist potencies of naltrexamine bivalent ligands with conformationally restricted spacers
-
Portoghese, P. S.; Ronsisvalle, G.; Larson, D. L.; Takemori, A. E. Synthesis and opioid antagonist potencies of naltrexamine bivalent ligands with conformationally restricted spacers J. Med. Chem. 1986, 29, 1650-1653
-
(1986)
J. Med. Chem.
, vol.29
, pp. 1650-1653
-
-
Portoghese, P.S.1
Ronsisvalle, G.2
Larson, D.L.3
Takemori, A.E.4
-
160
-
-
77950309325
-
Oligoproline helices as structurally defined scaffolds for oligomeric G protein-coupled receptor ligands
-
Bonger, K. M.; Kapoerchan, V. V.; Grotenbreg, G. M.; van Koppen, C. J.; Timmers, C. M.; van der Marel, G. A.; Overkleeft, H. S. Oligoproline helices as structurally defined scaffolds for oligomeric G protein-coupled receptor ligands Org. Biomol. Chem. 2010, 8, 1881-1884
-
(2010)
Org. Biomol. Chem.
, vol.8
, pp. 1881-1884
-
-
Bonger, K.M.1
Kapoerchan, V.V.2
Grotenbreg, G.M.3
Van Koppen, C.J.4
Timmers, C.M.5
Van Der Marel, G.A.6
Overkleeft, H.S.7
-
161
-
-
70350267056
-
Effects of terminal functional groups on the stability of the polyproline II structure: A combined experimental and theoretical study
-
Kuemin, M.; Schweizer, S.; Ochsenfeld, C.; Wennemers, H. Effects of terminal functional groups on the stability of the polyproline II structure: a combined experimental and theoretical study J. Am. Chem. Soc. 2009, 131, 15474-15482
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 15474-15482
-
-
Kuemin, M.1
Schweizer, S.2
Ochsenfeld, C.3
Wennemers, H.4
-
162
-
-
84863362554
-
Design and synthesis of a bivalent ligand to explore the putative heterodimerization of the mu opioid receptor and the chemokine receptor CCR5
-
Yuan, Y.; Arnatt, C. K.; Li, G.; Haney, K. M.; Ding, D.; Jacob, J. C.; Selley, D. E.; Zhang, Y. Design and synthesis of a bivalent ligand to explore the putative heterodimerization of the mu opioid receptor and the chemokine receptor CCR5 Org. Biomol. Chem. 2012, 10, 2633-2646
-
(2012)
Org. Biomol. Chem.
, vol.10
, pp. 2633-2646
-
-
Yuan, Y.1
Arnatt, C.K.2
Li, G.3
Haney, K.M.4
Ding, D.5
Jacob, J.C.6
Selley, D.E.7
Zhang, Y.8
-
163
-
-
84864982116
-
Tuned-affinity bivalent ligands for the characterization of opioid receptor heteromers
-
Harvey, J. H.; Long, D. H.; England, P. M.; Whistler, J. L. Tuned-affinity bivalent ligands for the characterization of opioid receptor heteromers ACS Med. Chem. Lett. 2012, 3, 640-644
-
(2012)
ACS Med. Chem. Lett.
, vol.3
, pp. 640-644
-
-
Harvey, J.H.1
Long, D.H.2
England, P.M.3
Whistler, J.L.4
-
164
-
-
0034687241
-
N, N -Diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide: A novel, exceptionally selective, potent delta opioid receptor agonist with oral bioavailability and its analogues
-
Wei, Z. Y.; Brown, W.; Takasaki, B.; Plobeck, N.; Delorme, D.; Zhou, F.; Yang, H.; Jones, P.; Gawell, L.; Gagnon, H.; Schmidt, R.; Yue, S. Y.; Walpole, C.; Payza, K.; St-Onge, S.; Labarre, M.; Godbout, C.; Jakob, A.; Butterworth, J.; Kamassah, A.; Morin, P. E.; Projean, D.; Ducharme, J.; Roberts, E. N, N -Diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide: a novel, exceptionally selective, potent delta opioid receptor agonist with oral bioavailability and its analogues J. Med. Chem. 2000, 43, 3895-3905
-
(2000)
J. Med. Chem.
, vol.43
, pp. 3895-3905
-
-
Wei, Z.Y.1
Brown, W.2
Takasaki, B.3
Plobeck, N.4
Delorme, D.5
Zhou, F.6
Yang, H.7
Jones, P.8
Gawell, L.9
Gagnon, H.10
Schmidt, R.11
Yue, S.Y.12
Walpole, C.13
Payza, K.14
St-Onge, S.15
Labarre, M.16
Godbout, C.17
Jakob, A.18
Butterworth, J.19
Kamassah, A.20
Morin, P.E.21
Projean, D.22
Ducharme, J.23
Roberts, E.24
more..
-
165
-
-
77950585850
-
Modulation of cell surface expression of nonactivated cholecystokinin receptors using bivalent ligand-induced internalization
-
Harikumar, K. G.; Akgun, E.; Portoghese, P. S.; Miller, L. J. Modulation of cell surface expression of nonactivated cholecystokinin receptors using bivalent ligand-induced internalization J. Med. Chem. 2010, 53, 2836-2842
-
(2010)
J. Med. Chem.
, vol.53
, pp. 2836-2842
-
-
Harikumar, K.G.1
Akgun, E.2
Portoghese, P.S.3
Miller, L.J.4
|