A bivalent ligand (KDN-21) reveals spinal δ and κ opioid receptors are organized as heterodimers that give rise to δ1 and δ2 phenotypes. Selective targeting of δ-κ heterodimers

Journal of Medicinal Chemistry

Volumn 47, Issue 12, 2004, Pages 2969-2972

  Bhushan, Rashmi G ^a   Sharma, Shiv K ^a   Xie, Zhihua ^a   Daniels, David J ^a   Portoghese, Philip S ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; BREMAZOCINE; DELTORPHIN; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; G PROTEIN COUPLED RECEPTOR; KAPPA OPIATE RECEPTOR; KDN 21; LIGAND; MU OPIATE RECEPTOR; NORBINALTORPHIMINE; OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DIMERIZATION; DRUG RECEPTOR BINDING; GENE TARGETING; HUMAN; HUMAN CELL; LIGAND BINDING; MOUSE; NONHUMAN; OLIGOMERIZATION; PHARMACOPHORE; PHENOTYPE; PROTEIN FAMILY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RECEPTOR AFFINITY; SPINAL CORD; TAIL FLICK TEST;

ANIMALS; CELL LINE; HUMANS; LIGANDS; MICE; NALTREXONE; OLIGOPEPTIDES; PHENOTYPE; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 2542625998     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0342358     Document Type: Article

References (25)

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