Univalent and bivalent ligands of butorphan: Characteristics of the linking chain determine the affinity and potency of such opioid ligands

Journal of Medicinal Chemistry

Volumn 52, Issue 23, 2009, Pages 7389-7396

  Decker, Michael ^a,c   Fulton, Brian S ^a   Zhang, Bin ^a   Knapp, Brian I ^b   Bidlack, Jean M ^b   Neumeyer, John L ^a  

^a MCLEAN HOSPITAL   (United States)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^c QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIS(N CYCLOBUTYLMETHYLMORPHINAN 3 YL) 2,2,9,9 TETRAMETHYLDECANEDIOATE; BIS(N CYCLOBUTYLMETHYLMORPHINAN 3 YL) 2,9 DIMETHYLDECANEDIOATE; BUTORPHANOL; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); MORPHINAN DERIVATIVE; OPIATE RECEPTOR; SULFUR 35; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING ASSAY; CONTROLLED STUDY; DRUG BINDING; DRUG POTENCY; DRUG SENSITIVITY; DRUG STRUCTURE; FEMALE; HYDROLYSIS; IN VITRO STUDY; LIGAND BINDING; NONHUMAN;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; HYDROLYSIS; LIGANDS; MORPHINANS; PROTEIN BINDING; RECEPTORS, OPIOID;

EID: 72249095188     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900379p     Document Type: Article

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