1,1′-Disubstituted ferrocenes as molecular hinges in mono- and bivalent dopamine receptor ligands

Journal of Medicinal Chemistry

Volumn 52, Issue 21, 2009, Pages 6860-6870

  Huber, Daniela ^a   Hubner, Harald ^a   Gmeiner, Peter ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1',1'' DODECANE 1,12 DIYLBIS(1H 1,2,3 TRIAZOLE 1,4 DIYL)DIFERROCENE 1 CARBALDEHYDE; 1',11'' [BIPHENYL 4,4' DIYLBIS(METHYLENE 1H 1,2,3 TRIAZOLE 1,4 DIYL)BIS(N [4 [4 (2 METHOXYPHENYL)PIPIERAZIN 1 YL]BUTYL]FERROCENE 1 CARBOXAMIDE; 1,1' [DECANE 1,10 DIYLBIS(1H 1,2,3 TRIAZOLE 1,4 DIYLFERROCENE 1,1' DIYLMETHYLENE)BIS[4 (2 METHOXYPHENYL)PIPERAZINE; 1,1'' (BIPHENYL 1,4,4' DIYLBIS(METHYLENE 1H 1,2,3 TRIAZOLE 1,4 DIYL)DIFERROCENE 1 CARBALDEHYDE; 1,1'' (DECANE 1,10 DIYLBIS(1H 1,2,3 TRIAZOLE 1,4 DIYL)DIFERROCENE 1 CARBALDEHYDE; 1,1'' [DECANE 1,10 DIYLBIS(1H 1,2,3 TRIAZOLE 1,4 DIYL)BIS (N [4 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]BUTYL]FERROCENE 1 CARBOXAMIDE; 1,1'' [DECANE 1,10 DIYLBIS(1H 1,2,3 TRIZAOLE 1,4 DIYL)BIS (N [3 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]PROPYL]FERROCENE 1 CARBOXAMIDE; 1,1'' [DODECANE 1,12 DIYLBIS(1H 1,2,3 TRIAZOLE 1,4 DIYL)BIS (N [3 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL)FERROCENE 1 CARBOXAMIDE; 1,1'[BIPHENYL 4,4' DIYLBIS(METHYLENE 1H 1,2,3 TRIAZOLE 1,4 DIYLFERROCENE 1,1' DIYLMETHYLENE)BIS[4(2 METHOXYPHENYL)PIPERAZINE; ASCORBIC ACID; DOPAMINE 3 RECEPTOR; DOPAMINE 4 RECEPTOR; FERROCENE DERIVATIVE; TRIAZOLE; UNCLASSIFIED DRUG; 1' (1 BENZYL 1H 1,2,3 TRIAZOLE 4 YL) N {(4 (4 (2 METHOXYPHENYL)PIPERAZIN 1 YL)BUTYL)FERROCENE 1 CARBOXAMIDE; 1'-(1-BENZYL-1H-1,2,3-TRIAZOLE-4-YL)-N-{(4-(4-(2-METHOXYPHENYL)PIPERAZIN-1-YL)BUTYL)FERROCENE-1-CARBOXAMIDE; DOPAMINE RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; FERROCENE; FERROUS ION; LIGAND;

ARTICLE; BINDING AFFINITY; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG STRUCTURE; DRUG SYNTHESIS; PROTON NUCLEAR MAGNETIC RESONANCE; RECEPTOR BINDING; ANIMAL; CHEMISTRY; CHO CELL; CORPUS STRIATUM; CRICETULUS; DIMERIZATION; HAMSTER; HUMAN; IN VITRO STUDY; METABOLISM; PARTIAL AGONISM; RADIOASSAY; STRUCTURE ACTIVITY RELATION; SWINE; SYNTHESIS;

ANIMALS; CHO CELLS; CORPUS STRIATUM; CRICETINAE; CRICETULUS; DIMERIZATION; DOPAMINE AGONISTS; DOPAMINE ANTAGONISTS; DRUG PARTIAL AGONISM; FERROUS COMPOUNDS; HUMANS; LIGANDS; RADIOLIGAND ASSAY; RECEPTORS, DOPAMINE; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 71049142202     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm901120h     Document Type: Article

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