Oligomeric potential of the M2 muscarinic cholinergic receptor

Journal of Neurochemistry

Volumn 90, Issue 3, 2004, Pages 537-548

  Park, Paul S H ^a   Wells, James W ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cooperativity; G protein coupled receptor; Immunoprecipitation; Protein purification; Receptor oligomerization; Signal transduction

Indexed keywords

ANTIBODY; EPITOPE; GUANINE NUCLEOTIDE BINDING PROTEIN; HEMAGGLUTININ; MUSCARINIC M2 RECEPTOR; MYC PROTEIN; OLIGOMER; PROTEIN FLAG; UNCLASSIFIED DRUG; HYBRID PROTEIN;

ARTICLE; CHOLINERGIC SYSTEM; CHROMATOGRAPHY; COMPLEX FORMATION; IMMUNOBLOTTING; IMMUNOPRECIPITATION; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; ANIMAL; ANTIBODY SPECIFICITY; ARMYWORM; CELL LINE; CHEMISTRY; GENETICS; HUMAN; MACROMOLECULE; METABOLISM; PHYSIOLOGY; PROTEIN BINDING; SERODIAGNOSIS; WESTERN BLOTTING;

ANIMALS; ANTIBODY SPECIFICITY; BLOTTING, WESTERN; CELL LINE; EPITOPES; HUMANS; IMMUNOBLOTTING; MACROMOLECULAR SUBSTANCES; PRECIPITIN TESTS; PROTEIN BINDING; RECEPTOR, MUSCARINIC M2; RECOMBINANT FUSION PROTEINS; SPODOPTERA;

EID: 3343026033     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2004.02536.x     Document Type: Article

References (49)

1. Angers S., Salahpour A. and Bouvier M. (2002) Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function. Annu. Rev. Pharmacol. Toxicol. 42, 409-435.
2. 2 receptor dimer formation: evidence from ligand binding. J. Biol. Chem. 276, 22621-22629.
3. Ayoub M. A., Couturier C., Lucas-Meunier E., Angers S., Fossier P., Bouvier M. and Jockers R. (2002) Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer. J. Biol. Chem. 277, 21522-21528.
4. Birdsall N. J. M., Burgen A. S. V. and Hulme E. C. (1977) Correlation between the binding properties and pharmacological responses of muscarinic receptors. Adv. Behav. Biol. 24, 25-33.
5. Birnbaumer L., Abramowitz J. and Brown A. M. (1990) Receptor-effector coupling by G proteins. Biochim. Biophys. Acta. 1031, 163-224.
6. Bockaert J., Marin P., Dumuis A. and Fagni L. (2003) The 'magic tail' of G protein-coupled receptors: an anchorage for functional protein networks. FEBS Lett. 546, 65-72.
7. Brady A. E. and Limbird L. E. (2002) G protein-coupled receptor interacting proteins: emerging roles in localization and signal transduction. Cell. Signal. 14, 297-309.
8. Burgisser E., De Lean A. and Lefkowitz R. J. (1982) Reciprocal modulation of agonist and antagonist binding to muscarinic cholinergic receptor by guanine nucleotide. Proc. Natl Acad. Sci. USA 79, 1732-1736.
9. 2A receptors: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer. J. Neurochem. 88, 726-734.
10. Chidiac P. and Wells J. W. (1992) Effects of adenyl nucleotides and carbachol on cooperative interactions among G proteins. Biochemistry 31, 10908-10921.
11. Chidiac P., Green M. A., Pawagi A. B. and Wells J. W. (1997) Cardiac muscarinic receptors. Cooperativity as the basis for multiple states of affinity. Biochemistry 36, 7361-7379.
12. De Lean A., Stadel J. M. and Lefkowitz R. J. (1980) A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled β-adrenergic receptor. J. Biol. Chem. 255, 7108-7117.
13. Ehlert F. J. (1985) The relationship between muscarinic receptor occupancy and adenylate cyclase inhibition in the rabbit myocardium. Mol. Pharmacol. 28, 410-421.
14. Galvez T., Duthey B., Kniazeff J., Blahos J., Rovelli G., Bettler B., Prezeau L. and Pin J. P. (2001) Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA (B) receptor function. EMBO J. 20, 2152-2159.
15. Gazi L., Lopez-Gimenez J. F. and Strange P. G. (2002) Formation of oligomers by G protein-coupled receptors. Curr. Opin. Drug Discov. Devel. 5, 756-763.
16. Gilman A. G. (1987) G proteins: transducers of receptor-generated signals. Annu. Rev. Biochem. 56, 615-649.
17. Gomes I., Jordan B. A., Gupta A., Rios C., Trapaidze N. and Devi L. A. (2001) G protein coupled receptor dimerization: implications in modulating receptor function. J. Mol. Med. 79, 226-242.
18. Green M. A., Chidiac P. and Wells J. W. (1997) Cardiac muscarinic receptors: relationship between the G protein and multiple states of affinity. Biochemistry 36, 7380-7394.
19. 2 receptor homodimer. J. Biol. Chem. 278, 4385-4388.
20. Hall R. A. and Lefkowitz R. J. (2002) Regulation of G protein-coupled receptor signaling by scaffold proteins. Circ. Res. 91, 672-680.
21. 2 muscarinic receptors in Sf9 cells: characterisation and reconstitution with G-proteins. J. Recept. Signal Transduct. Res. 15, 55-70.
22. Higgins M. K., Demir M. and Tate C. G. (2003) Calnexin co-expression and the use of weaker promoters increase the expression of correctly assembled Shaker potassium channel in insect cells. Biochim. Biophys. Acta. 1610, 124-132.
23. Hulme E. C., Berrie C. P., Birdsall N. J. and Burgen A. S. (1981) Two populations of binding sites for muscarinic antagonists in the rat heart. Eur. J. Pharmacol. 73, 137-142.
24. Jordan B. A. and Devi L. A. (1999) G-protein-coupled receptor heterodimerization modulates receptor function. Nature 399, 697-700.
25. Kent R. S., De Lean A. and Lefkowitz R. J. (1980) A] quantitative analysis of β-adrenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modeling of ligand binding data. Mol. Pharmacol. 17, 14-23.
26. Klco J. M., Lassere T. B. and Baranski T. J. (2003) C5a receptor oligomerization. I. Disulfide trapping reveals oligomers and potential contact surfaces in a G protein-coupled receptor. J. Biol. Chem. 278, 35345-35353.
27. 2-adrenergic receptor heterodimers. Can. J. Physiol. Pharmacol. 81, 186-195.
28. Le Gouill C., Parent J. L., Caron C.-A., Gaudreau R., Volkov L., Rola-Pleszczynski M. and Stanková J. (1999) Selective modulation of wild type receptor functions by mutants of G-protein-coupled receptors. J. Biol. Chem. 274, 12548-12554.
29. Lee T. W. T., Sole M. J. and Wells J. W. (1986) Assessment of a ternary model for the binding of agonists to neurohumoral receptors. Biochemistry 25, 7009-7020.
30. Liang Y., Fotiadis D., Filipek S., Saperstein D. A., Palczewski K. and Engel A. (2003) Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes. J. Biol. Chem. 278, 21655-21662.
31. Lu Z. L., Saldanha J. W. and Hulme E. C. (2002) Seven-transmembrane receptors: crystals clarify. Trends Pharmacol. Sci. 23, 140-146.
32. 2-adrenergic receptor homo- and heterodimerization by bioluminescence resonance energy transfer. J. Biol. Chem. 277, 44925-44931.
33. Milligan G. (2001) Oligomerisation of G-protein-coupled receptors. J. Cell Sci. 114, 1265-1271.
34. Müller D. J., Sass H.-J., Müller S. A., Büldt G. and Engel A. (1999) Surface structures of native bacteriorhodopsin depend on the molecular packing arrangement in the membrane. J. Mol. Biol. 285, 1903-1909.
35. 2 muscarinic cholinergic receptor purified from Sf9 cells. Biochemistry 42, 12960-12971.
36. Park P., Sum C. S., Hampson D. R., Van Tol H. H. M. and Wells J. W. (2001) Nature of the oligomers formed by muscarinic m2 acetylcholine receptors in Sf9 cells. Eur. J. Pharmacol. 421, 11-22.
37. Park P. S.-H., Sum C. S., Pawagi A. B. and Wells J. W. (2002) Cooperativity and oligomeric status of cardiac muscarinic cholinergic receptors. Biochemistry 41, 5588-5604.
38. Parker E. M., Kameyama K., Higashijima T. and Ross E. M. (1991) Reconstitutively active G protein-coupled receptors purified from baculovirus-infected insect cells. J. Biol. Chem. 266, 519-527.
39. Rocheville M., Lange D. C., Kumar U., Patel S. C., Patel R. C. and Patel Y. C. (2000) Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity. Science 288, 154-157.
40. 2-adrenergic receptor dimers and oligomers. Biol. Chem. 384, 117-123.
41. 3H]histamine in guinea pig cerbral cortex. II. Mechanistic basis for multiple states of affinity. Mol. Pharmacol. 43, 583-594.
42. Strader C. D., Fong T. M., Tota M. R., Underwood D. and Dixon R. A. (1994) Structure and function of G protein-coupled receptors. Annu. Rev. Biochem. 63, 101-132.
43. Terrillon S. and Bouvier M. (2004) Roles of G-protein-coupled receptor dimerization. EMBO Report 5, 30-34.
44. Terrillon S., Durroux T., Mouillac B., Breit A., Ayoub M. A., Taulan M., Jockers R., Barberis C. and Bouvier M. (2003) Oxytocin and vasopressin V1a and V2 receptors form constitutive homo- and heterodimers during biosynthesis. Mol. Endocrinol. 17, 677-691.
45. Vasudevan S., Hulme E. C., Bach M., Haase W., Pavia J. and Reiländer H. (1995) Characterization of the rat m3 muscarinic acetylcholine receptor produced in insect cells infected with recombinant baculovirus. Eur. J. Biochem. 227, 466-475.
46. 2- dopamine receptor of the anterior pituitary gland. Mol. Pharmacol. 26, 214-227.
47. Wreggett K. A. and Wells J. W. (1995) Cooperativity manifest in the binding properties of purified cardiac muscarinic receptors. J. Biol. Chem. 270, 22488-22499.
48. Yeung S. M. and Green R. D. (1983) Agonist and antagonist affinities for inhibitory adenosine receptors are reciprocally affected by 5′- guanylylimidodiphosphate or N-ethylmaleimide. J. Biol. Chem. 258, 2334-2339.
49. Zhu X. and Wess J. (1998) Truncated V2 vasopressin receptors as negative regulators of wild-type V2 receptor function. Biochemistry 37, 15773-15784.