Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 52, 2005, Pages 19208-19213

  Daniels, David J ^a   Lenard, Natalie R ^b   Etienne, Chris L ^a   Law, Ping Yee ^c   Roerig, Sandra C ^b   Portoghese, Philip S ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Antinociception; Heterodimers

Indexed keywords

DELTA OPIATE RECEPTOR; DELTA OPIATE RECEPTOR ANTAGONIST; LIGAND; MORPHINE; MU DELTA OPIATE RECEPTOR AGONIST ANTAGONIST; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; NALOXONE; NALTRINDOLE; OPIATE; OPIATE AGONIST; OPIATE ANTAGONIST; OXYMORPHONE; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; BRAIN VENTRICLE; CONTROLLED STUDY; DISEASE MODEL; DRUG DEPENDENCE; DRUG POTENCY; DRUG TOLERANCE; EXPERIMENTAL ANIMAL; MALE; MOUSE; NEUROPATHOLOGY; NONHUMAN; OPIATE ADDICTION; OSMOTIC MINIPUMP; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; TAIL FLICK TEST;

ANALGESICS; ANALGESICS, OPIOID; ANIMALS; CHEMISTRY, PHARMACEUTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; LIGANDS; MALE; MICE; MICE, INBRED ICR; MODELS, CHEMICAL; MODELS, STATISTICAL; MORPHINE; NALTREXONE; NARCOTIC ANTAGONISTS; NARCOTICS; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU; TIME FACTORS;

ANIMALIA;

EID: 30044442319     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0506627102     Document Type: Article

References (43)

1. Vaught, J. & Takemori, A. (1979) J. Pharmacol. Exp. Ther. 208, 86-94.
2. Vaught, J. L., Rothman, R. B. & Westfall, T. C. (1982) Life Sci. 30, 1443-1455.
3. Heyman, J. S. & Porreca, F. (1989) Prog. Opioid Res. 75, 467-470.
4. Miyamoto, Y., Portoghese, P. S. & Takemori, A. E. (1993) J. Pharmacol. Exp. Ther. 264, 1141-1145.
5. Ahdelhamid, E. E., Sultana, M., Portoghese, P. S. & Takemori, A. E. (1991) J. Pharmacol. Exp. Ther. 258, 299-303.
6. Miyamoto, Y., Brown, W. D., Portoghese, P. S. & Takemori, A. E. (1994) J. Pharmacol. Exp. Ther. 270, 37-39.
7. Fundytus, M. E., Schiller, P. W., Shapiro, M., Weltrowska, G. & Coderre, T. J. (1995) Eur. J. Pharmacol. 286. 105-108.
8. Sánchez-Blázquez, P., García-España, A. & Garzón, J. (1997) J. Pharmacol. Exp. Ther. 280, 1423-1431.
9. Kest, B., Lee, C. E., McLenmore, G. L. & Inturrisi, C. E. (1996) Brain Res. Bull. 39, 185-189.
10. Zhu, Y., King, M. A., Schuller, A. G., Nitsche, J. F., Reidl, M., Elde, R. P., Unterwald, E., Pasternak, G. W. & Pintar, J. E. (1999) Neuron 24, 243-252.
11. Schiller, P. W., Fundytus, M. E., Merovitz, L., Weltorski, G., Nguyen, T. M., Lemieux, C., Chung, N. N. & Coderre, T. (1999) J. Med. Chem. 42, 3520-3526.
12. Wells, J. L., Bartlett, J. L., Ananthan, S. & Bilsky, E. J. (2001) J. Pharmacol. Exp. Ther. 297, 597-605.
13. Ananthan, S., Kezar H. S., Carter, R. L., Saini, S. K., Rice, K. C., Wells, J. L., David, P., Xu, H., Dersch, C. M., Bilsky, E. J., et al. (1999) J. Med. Chem. 42, 3527-3538.
14. George, S. R., Fan, T., Xie Z., Tse R., Tam, V., Varghese, G. & O'Dowd, B. F. (2000) J. Biol. Chem. 275, 26128-26135.
15. Gomes, I., Jordan, B. A., Gupta, A., Trapaidze, N., Nagy, V. & Devi, L. A. (2000) J. Neurosci. 20, 1-5.
16. Gomes, I., Gupta, A., Filipovska, J., Szeto, H. H., Pintar, J. E. & Devi, L. A. (2004) Proc. Natl. Acad. Sci. USA 101, 5135-5139.
17. Erez, M., Takemori, A. E. & Portoghcse, P. S. (1982) J. Med. Chem. 25, 847-849.
18. Portoghese, P. S., Ronsisvalle, G., Larson, D. L., Yim, C. B., Sayre, L. M. & Takemori, A. E. (1982) Life Sci. 31, 1283-1286.
19. Hazum, E., Chang, K.-J., Leighton, H. J., Lever, O. W., Cuatrecasas, P. (1982) Biochem. Biophys. Res. Commun. 104, 347-353.
20. Portoghese, P. S., Larson, D. L., Yim, C. B., Sayre, L. M., Ronsisvalle, G., Lipkowski A. W., Takemori, A. E., Rice, K. C. & Tam, S. W. (1985) J. Med. Chem. 28, 1140-1141.
21. Portoghese, P. S., Ronsisvalle, G., Larson, D. L. & Takemori, A. E. (1986) J. Med. Chem. 29, 1650-1653.
22. Portoghese, P. S., Larson, D. L., Sayre, L. M., Yim, C. B., Ronsisvalle, G., Tam, S. W. & Takemori, A. E. (1986) J. Med. Chem. 29, 1855-1861.
23. Portoghese, P. S., Larson, D. L., Ronsisvalle, G., Schiller, P. W., Nguyen, T. M., Lemieux, C. & Takemori, A. E. (1987) J. Med. Chem. 30, 1991-1994.
24. Takemori, A. E., Yim, C. B., Larson, D. L. & Portoghese, P. S. (1990) Eur. J. Pharmacol. 186, 285-288.
25. Shimohigashi, Y., Costa, T., Chen, H.-C. & Rodhard, D. (1982) Nature 297, 333-335.
26. Costa, T., Shimohigashi, Y., Krumins, S. A., Munson, P. J. & Rodhard, D. (1982) Life Sci. 31, 1625-1632.
27. Costa, T., Wuster, M., Herz, A., Shimohigashi, Y., Chen, H. C. & Rodhard, D. (1985) Biochem. Pharmacol. 34, 25-30.
28. Sasaki-Yagi, Y., Kimura, S. & Imanishi, Y. (1991) Int. J. Pept. Protein Res. 38, 378-384.
29. Bhushan, R. G., Sharma, S. K., Xie, Z., Daniels, D. J. & Portoghese, P. S. (2004) J. Med. Chem. 47, 2969-2972.
30. Daniels, D. J., Kulkarni, A., Xie, Z., Bhushan, R. G. & Portoghese, P. S. (2005) J. Med. Chem. 48, 1713-1716.
31. Haley, T. J. & McCormick, W. G. (1957) Br. J. Pharmacol. Chemother. 12, 12-15.
32. D'Amour, F. E. & Smith, D. L. (1941) J. Pharmacol. Exp. Ther. 72, 74-79.
33. Lenard, N. R. & Roerig, S. C., Eur. J. Pharmacol. in press.
34. Way, E. L., Loh, H. H. & Shen, F. H. (1969) J. Pharmacol. Exp. Ther. 167, 1-8.
35. Sayre, L. M, & Portoghese, P. S. (1980) J. Med. Chem. 45, 3366-3368.
36. Portoghese, P. S., Sultana, M. & Takemori, A. E. (1990) J. Med. Chem. 33, 1714-1720.
37. Waldhoer, M., Fonj, J., Jones, R. M., Lunzer, M. M., Sharma, S. K., Kostenis, E., Portoghese, P. S. & Whistler, J. L. (2005) Proc. Natl. Acad. Sci. USA 102, 9050-9055.
38. Portoghese, P. S. (2001) J. Med. Chem. 44, 2259-2269.
39. Xie, Z., Bhushan, R. G., Daniels, D. J. & Portoghese, P. S. (2005) Mol. Pharmacol. 68, 1079-1086.
40. Cvejic, S. & Devi, L. A. (1997) J. Biol. Chem. 272, 26959-26964.
41. Taylor, D. A. & Fleming, W. W. (2001) J. Pharmacol. Exp. Ther. 297, 11-18.
42. Aley, K. O. & Levine, J. D. (1997) J. Neurosci. 17, 8018-8023.
43. Rubini, P., Schulz, R., Wuster, M. & Herz, A. (1982) Naunyn Schmiedebergs Arch. Pharmacol 319, 142-146.