A bivalent ligand (KDAN-18) containing δ-antagonist and κ-agonist pharmacophores bridges δ2 and κ1 opioid receptor phenotype

Journal of Medicinal Chemistry

Volumn 48, Issue 6, 2005, Pages 1713-1716

  Daniels, David J ^a   Kulkarni, Amol ^a   Xie, Zhihua ^a   Bhushan, Rashmi G ^a   Portoghese, Philip S ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DICHLORO N METHYL N [1 PHENYL 2 (1 PYRROLIDINYL)ETHYL]BENZENEACETAMIDE; DELTA OPIATE RECEPTOR ANTAGONIST; KAPPA OPIATE RECEPTOR AGONIST; KDAN 12; KDAN 18; KDAN 20; LIGAND; NALTRIBEN; NALTRINDOLE; OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BINDING; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; EXPERIMENTAL MODEL; MOUSE; NONHUMAN; OLIGOMERIZATION; PHARMACOPHORE; PHENOTYPE; SPINAL CORD; STRUCTURE ACTIVITY RELATION; TAIL FLICK TEST;

ALLOSTERIC REGULATION; AMIDES; ANIMALS; BINDING, COMPETITIVE; CELL LINE; HUMANS; INJECTIONS, SPINAL; LIGANDS; MICE; NALTREXONE; PHENOTYPE; PYRROLIDINES; RADIOLIGAND ASSAY; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 15444364860     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm034234f     Document Type: Article

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